Srm (spermidine synthase) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Srm (spermidine synthase) Rattus norvegicus
Analyze
Symbol: Srm
Name: spermidine synthase
RGD ID: 620796
Description: Enables spermidine synthase activity. Involved in spermidine biosynthetic process. Predicted to be active in cytosol. Orthologous to human SRM (spermidine synthase); PARTICIPATES IN spermidine metabolic pathway; glycine N-methyltransferase deficiency pathway; homocystinuria pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC100912604; LOC689673; similar to Spermidine synthase (Putrescine aminopropyltransferase) (SPDSY); spermidine synthase-like
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25159,025,919 - 159,029,076 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5159,025,873 - 159,029,405 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5161,742,582 - 161,745,783 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.05163,565,057 - 163,568,258 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.05163,521,402 - 163,524,603 (+)NCBIRnor_WKY
Rnor_6.05165,405,168 - 165,408,325 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl314,588,870 - 14,591,974 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl5165,405,168 - 165,408,320 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05169,061,769 - 169,064,926 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45165,672,516 - 165,675,673 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15165,682,703 - 165,685,859 (+)NCBI
Celera5157,302,130 - 157,305,203 (+)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-alpha-phellandrene  (ISO)
(-)-demecolcine  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4,6-trinitrotoluene  (EXP)
2,4-dinitrotoluene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-chloropropane-1,2-diol  (EXP)
4-amino-2,6-dinitrotoluene  (EXP)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
acrylamide  (ISO)
afimoxifene  (ISO)
all-trans-retinoic acid  (ISO)
alpha-phellandrene  (ISO)
amiodarone  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
azoxystrobin  (ISO)
beauvericin  (ISO)
benzbromarone  (EXP)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
cadmium dichloride  (EXP)
caffeine  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
choline  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
clofibrate  (EXP,ISO)
clofibric acid  (EXP)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
curcumin  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
cypermethrin  (ISO)
dibutyl phthalate  (ISO)
dicrotophos  (ISO)
dioxygen  (ISO)
doxorubicin  (ISO)
Enterolactone  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
fenthion  (ISO)
flutamide  (EXP)
folic acid  (ISO)
genistein  (EXP,ISO)
glafenine  (EXP)
hydrogen peroxide  (ISO)
isoprenaline  (ISO)
ivermectin  (ISO)
L-ethionine  (EXP)
L-methionine  (ISO)
metformin  (EXP)
methidathion  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
N-(6-acetamidohexyl)acetamide  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (EXP)
nefazodone  (EXP)
nickel atom  (ISO)
nimesulide  (EXP)
omeprazole  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
phenobarbital  (ISO)
PhIP  (EXP)
pirinixic acid  (EXP,ISO)
propiconazole  (ISO)
pyrazinecarboxamide  (EXP)
rotenone  (EXP)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
Soman  (EXP)
tamoxifen  (ISO)
tebufenpyrad  (ISO)
testosterone  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (EXP,ISO)
triptonide  (ISO)
trovafloxacin  (EXP)
urethane  (ISO)
valdecoxib  (EXP)
valproic acid  (EXP,ISO)
vincristine  (ISO)
zinc dichloride  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Synthetic decarboxylated S-adenosyl-L-methionine as a substrate for aminopropyl transferases. Dejima H, etal., Biol Pharm Bull 2003 Jul;26(7):1005-8.
2. Aminooxy analogues of spermidine as inhibitors of spermine synthase and substrates of hepatic polyamine acetylating activity. Eloranta TO, etal., J Biochem. 1990 Oct;108(4):593-8.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
6. S-adenosylmethionine in liver health, injury, and cancer. Lu SC and Mato JM, Physiol Rev. 2012 Oct;92(4):1515-42. doi: 10.1152/physrev.00047.2011.
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
10. GOA pipeline RGD automated data pipeline
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Assay for spermidine synthase activity by micellar electrokinetic chromatography with laser-induced fluorescence detection. Sano M and Nishino I, J Chromatogr B Analyt Technol Biomed Life Sci. 2007 Jan 1;845(1):80-3. Epub 2006 Aug 23.
13. Effects of inhibitors of spermidine synthase and spermine synthase on polyamine synthesis in rat tissues. Shirahata A, etal., Biochem Pharmacol. 1993 May 5;45(9):1897-903.
14. A perspective of polyamine metabolism. Wallace HM, etal., Biochem J. 2003 Nov 15;376(Pt 1):1-14.
Additional References at PubMed
PMID:12477932   PMID:16515550   PMID:17585781   PMID:20439489   PMID:29892012   PMID:31515488  


Genomics

Comparative Map Data
Srm
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25159,025,919 - 159,029,076 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5159,025,873 - 159,029,405 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5161,742,582 - 161,745,783 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.05163,565,057 - 163,568,258 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.05163,521,402 - 163,524,603 (+)NCBIRnor_WKY
Rnor_6.05165,405,168 - 165,408,325 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl314,588,870 - 14,591,974 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl5165,405,168 - 165,408,320 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05169,061,769 - 169,064,926 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45165,672,516 - 165,675,673 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15165,682,703 - 165,685,859 (+)NCBI
Celera5157,302,130 - 157,305,203 (+)NCBICelera
Cytogenetic Map5q36NCBI
SRM
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38111,054,589 - 11,060,018 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl111,054,584 - 11,060,020 (-)EnsemblGRCh38hg38GRCh38
GRCh37111,114,646 - 11,120,075 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36111,037,236 - 11,042,678 (-)NCBINCBI36Build 36hg18NCBI36
Build 34111,048,942 - 11,054,347NCBI
Celera110,226,954 - 10,232,396 (-)NCBICelera
Cytogenetic Map1p36.22NCBI
HuRef110,266,094 - 10,271,363 (-)NCBIHuRef
CHM1_1111,102,556 - 11,108,076 (-)NCBICHM1_1
T2T-CHM13v2.0110,596,153 - 10,601,582 (-)NCBIT2T-CHM13v2.0
Srm
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394148,675,970 - 148,679,076 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4148,675,960 - 148,679,450 (+)EnsemblGRCm39 Ensembl
GRCm384148,591,513 - 148,594,619 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4148,591,503 - 148,594,993 (+)EnsemblGRCm38mm10GRCm38
MGSCv374147,965,622 - 147,968,728 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364147,435,313 - 147,438,419 (+)NCBIMGSCv36mm8
Celera4150,853,070 - 150,856,182 (+)NCBICelera
Cytogenetic Map4E2NCBI
Srm
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554862,631,586 - 2,634,527 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554862,631,579 - 2,634,779 (+)NCBIChiLan1.0ChiLan1.0
SRM
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1111,038,452 - 11,043,186 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v019,817,765 - 9,823,244 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
SRM
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1284,968,833 - 84,973,111 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl284,967,570 - 84,973,087 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha281,499,046 - 81,502,445 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0285,631,078 - 85,634,460 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl285,631,106 - 85,636,493 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1282,379,185 - 82,382,581 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0283,380,647 - 83,384,031 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0284,443,471 - 84,446,868 (+)NCBIUU_Cfam_GSD_1.0
Srm
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505834,294,112 - 34,300,103 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936474118,000 - 124,963 (-)EnsemblSpeTri2.0
SpeTri2.0NW_004936474121,135 - 124,894 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SRM
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl671,246,876 - 71,253,508 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1671,246,895 - 71,253,534 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2665,154,834 - 65,158,866 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SRM
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120120,718,265 - 120,723,694 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20120,718,424 - 120,723,944 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605424,626,079 - 24,631,446 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Srm
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248181,725,480 - 1,732,186 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248181,725,614 - 1,729,374 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Srm
14 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:129
Count of miRNA genes:56
Interacting mature miRNAs:75
Transcripts:ENSRNOT00000014934, ENSRNOT00000071712
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5121846814166846814Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5124965598166875058Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5126424772166875058Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5127798274166875058Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5127798274166875058Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5128506074166875058Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5128506074166875058Rat
634349Bp139Blood pressure QTL 1390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5128924607166875058Rat
738018Anxrr4Anxiety related response QTL 45.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)5130130159166875058Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5131345754166875058Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5132717196165560427Rat
631562Apr2Acute phase response QTL 23.7blood murinoglobulin 1 amount (VT:0010597)plasma murinoglobulin 1 level (CMO:0001931)5135927956166875058Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5135929696166875058Rat
1331721Bp210Blood pressure QTL 2103.413arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5143069996166846814Rat
2302369Scl60Serum cholesterol level QTL 603.13blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)5143608201161165651Rat
2313096Bmd78Bone mineral density QTL 783.10.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)5144377876161317411Rat
1298090Bp155Blood pressure QTL 1553.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)5151006154161165494Rat
1354631Swd2Spike wave discharge measurement QTL 23.640.0002brain electrophysiology trait (VT:0010557)brain total spike-and-wave discharge duration (CMO:0001740)5151113452164465185Rat
631272Lanf1Left ventricular atrial natriuretic factor QTL 112heart left ventricle natriuretic peptide A amount (VT:0010596)heart left ventricle natriuretic peptide A level (CMO:0002165)5151113452166875058Rat
1549904Neuinf1Neuroinflammation QTL 130nervous system integrity trait (VT:0010566)blood T lymphocyte count (CMO:0000110)5154828214166875058Rat

Markers in Region
AA858619  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25159,028,823 - 159,029,024 (+)MAPPERmRatBN7.2
Rnor_6.0314,591,720 - 14,591,920NCBIRnor6.0
Rnor_6.05165,408,073 - 165,408,273NCBIRnor6.0
Rnor_5.05169,064,674 - 169,064,874UniSTSRnor5.0
Rnor_5.0319,903,052 - 19,903,252UniSTSRnor5.0
RGSC_v3.45165,675,421 - 165,675,621UniSTSRGSC3.4
Celera5157,304,951 - 157,305,151UniSTS
RH 3.4 Map51114.4UniSTS
Cytogenetic Map5q36UniSTS
Srm  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25159,028,206 - 159,028,887 (+)MAPPERmRatBN7.2
Rnor_6.0314,591,103 - 14,591,783NCBIRnor6.0
Rnor_6.05165,407,456 - 165,408,136NCBIRnor6.0
Rnor_5.0319,902,435 - 19,903,115UniSTSRnor5.0
Rnor_5.05169,064,057 - 169,064,737UniSTSRnor5.0
Celera5157,304,334 - 157,305,014UniSTS
Celera313,422,895 - 13,423,336UniSTS
Cytogenetic Map5q36UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium
Low 3 24 24 24 4 24 4 96 30 38 2
Below cutoff 2 41 57 40 17 40 8 9 39 26 28 11 8

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000014934   ⟹   ENSRNOP00000014934
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5159,025,873 - 159,029,069 (+)Ensembl
Rnor_6.0 Ensembl5165,405,168 - 165,408,320 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000071712   ⟹   ENSRNOP00000067465
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5159,025,873 - 159,029,405 (+)Ensembl
Rnor_6.0 Ensembl314,588,870 - 14,591,974 (+)Ensembl
RefSeq Acc Id: NM_053464   ⟹   NP_445916
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25159,025,919 - 159,029,076 (+)NCBI
Rnor_6.05165,405,168 - 165,408,325 (+)NCBI
Rnor_5.05169,061,769 - 169,064,926 (+)NCBI
RGSC_v3.45165,672,516 - 165,675,673 (+)RGD
Celera5157,302,130 - 157,305,203 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_445916 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI28734 (Get FASTA)   NCBI Sequence Viewer  
  AAK21288 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_445916   ⟸   NM_053464
- UniProtKB: Q99MI5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000014934   ⟸   ENSRNOT00000014934
RefSeq Acc Id: ENSRNOP00000067465   ⟸   ENSRNOT00000071712
Protein Domains
PABS

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q99MI5-F1-model_v2 AlphaFold Q99MI5 1-302 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694263
Promoter ID:EPDNEW_R4788
Type:initiation region
Name:Srm_1
Description:spermidine synthase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05165,405,160 - 165,405,220EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620796 AgrOrtholog
BioCyc Gene G2FUF-39160 BioCyc
BioCyc Pathway BSUBPOLYAMSYN-PWY [spermidine biosynthesis I] BioCyc
Ensembl Genes ENSRNOG00000011078 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00000046379 Ensembl
Ensembl Protein ENSRNOP00000014934 ENTREZGENE
  ENSRNOP00000014934.2 UniProtKB/TrEMBL
  ENSRNOP00000067465.2 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000014934 ENTREZGENE
  ENSRNOT00000014934.5 UniProtKB/TrEMBL
  ENSRNOT00000071712.3 UniProtKB/TrEMBL
Gene3D-CATH 2.30.140.10 UniProtKB/TrEMBL
  3.40.50.150 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:8366755 IMAGE-MGC_LOAD
InterPro PABS UniProtKB/TrEMBL
  PABS_CS UniProtKB/TrEMBL
  SAM-dependent_MTases-like UniProtKB/TrEMBL
  Spermi_synthase_euk UniProtKB/TrEMBL
  Spermidine_synt_N UniProtKB/TrEMBL
  Spermidine_synt_N_sf UniProtKB/TrEMBL
  Sprmine_synthase UniProtKB/TrEMBL
KEGG Report rno:84596 UniProtKB/TrEMBL
MGC_CLONE MGC:156617 IMAGE-MGC_LOAD
NCBI Gene 84596 ENTREZGENE
PANTHER PTHR11558 UniProtKB/TrEMBL
Pfam Spermine_synt_N UniProtKB/TrEMBL
PhenoGen Srm PhenoGen
PIRSF Spermidine_synth UniProtKB/TrEMBL
PROSITE SPERMIDINE_SYNTHASE_1 UniProtKB/TrEMBL
  SPERMIDINE_SYNTHASE_2 UniProtKB/TrEMBL
Superfamily-SCOP SSF53335 UniProtKB/TrEMBL
TIGRFAMs speE UniProtKB/TrEMBL
UniProt M0RCX8_RAT UniProtKB/TrEMBL
  Q99MI5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Srm  spermidine synthase  LOC100912604  spermidine synthase-like  Data Merged 737654 PROVISIONAL
2015-07-29 LOC100912604  spermidine synthase-like  LOC689673  similar to Spermidine synthase (Putrescine aminopropyltransferase) (SPDSY)  Data Merged 737654 PROVISIONAL
2012-07-05 LOC100912604  spermidine synthase-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-01-09 LOC689673  similar to Spermidine synthase (Putrescine aminopropyltransferase) (SPDSY)  LOC687838  similar to Spermidine synthase (Putrescine aminopropyltransferase) (SPDSY)  Data Merged 1643240 APPROVED
2006-11-20 LOC689673  similar to Spermidine synthase (Putrescine aminopropyltransferase) (SPDSY)      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-20 LOC687838  similar to Spermidine synthase (Putrescine aminopropyltransferase) (SPDSY)      Symbol and Name status set to provisional 70820 PROVISIONAL
2004-02-26 Srm  spermidine synthase      Symbol and Name status set to approved 625702 APPROVED
2002-08-07 Srm  spermidine synthase      Symbol and Name status set to provisional 70820 PROVISIONAL