Gene: Dffa (DNA fragmentation factor subunit alpha) Rattus norvegicus
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Symbol: Dffa
Name: DNA fragmentation factor subunit alpha
Description: ENCODES a protein that exhibits deoxyribonuclease inhibitor activity (ortholog); protein domain specific binding (ortholog); protein folding chaperone (ortholog); INVOLVED IN chaperone-mediated protein folding (ortholog); negative regulation of apoptotic DNA fragmentation (ortholog); negative regulation of deoxyribonuclease activity (ortholog); PARTICIPATES IN apoptotic cell death pathway; FOUND IN nucleus; cytosol (ortholog); nuclear chromatin (ortholog); INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1-chloro-2-[2,2-dichloro-1-(4-chlorophenyl)ethyl]benzene; 2,3,7,8-tetrachlorodibenzodioxine
AGR Description: Predicted to have deoxyribonuclease inhibitor activity, protein domain specific binding activity, and protein folding chaperone; predicted to be involved in several processes, including chaperone-mediated protein folding, negative regulation of cellular metabolic process, and positive regulation of apoptotic process; localizes to the nucleus; orthologous to human DFFA (DNA fragmentation factor subunit alpha).
Merged Description: Predicted to have deoxyribonuclease inhibitor activity, protein domain specific binding activity, and protein folding chaperone; predicted to be involved in several processes, including chaperone-mediated protein folding, negative regulation of cellular metabolic process, and positive regulation of apoptotic process; localizes to the nucleus; orthologous to human DFFA (DNA fragmentation factor subunit alpha); PARTICIPATES IN apoptotic cell death pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1-chloro-2-[2,2-dichloro-1-(4-chlorophenyl)ethyl]benzene; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: DNA fragmentation factor, alpha polypeptide; DNA fragmentation factor, alpha subunit; ICAD-S
Orthologs:
Homo sapiens (human) : DFFA (DNA fragmentation factor subunit alpha)  HGNC  Alliance
Mus musculus (house mouse) : Dffa (DNA fragmentation factor, alpha subunit)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dffa (DNA fragmentation factor subunit alpha)
Pan paniscus (bonobo/pygmy chimpanzee) : DFFA (DNA fragmentation factor subunit alpha)
Canis lupus familiaris (dog) : DFFA (DNA fragmentation factor subunit alpha)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dffa (DNA fragmentation factor subunit alpha)
Sus scrofa (pig) : DFFA (DNA fragmentation factor subunit alpha)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.05165,922,893 - 165,935,822 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.05169,573,089 - 169,586,003 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45166,179,130 - 166,192,029 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15166,189,332 - 166,200,048 (+)NCBI
Celera5157,811,683 - 157,824,582 (+)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Dffa
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 620334
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2019-04-12
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.