Dffa (DNA fragmentation factor subunit alpha) - Rat Genome Database

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Gene: Dffa (DNA fragmentation factor subunit alpha) Rattus norvegicus
Analyze
Symbol: Dffa
Name: DNA fragmentation factor subunit alpha
RGD ID: 620334
Description: Predicted to enable deoxyribonuclease inhibitor activity; protein domain specific binding activity; and protein folding chaperone. Predicted to be involved in several processes, including negative regulation of DNA metabolic process; negative regulation of execution phase of apoptosis; and protein folding. Predicted to act upstream of or within positive regulation of apoptotic process and thymocyte apoptotic process. Predicted to be located in cytosol; nucleus; and plasma membrane. Predicted to be part of protein-containing complex. Predicted to be active in chromatin. Orthologous to human DFFA (DNA fragmentation factor subunit alpha); PARTICIPATES IN apoptotic cell death pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: DNA fragmentation factor, alpha polypeptide; DNA fragmentation factor, alpha subunit; ICAD-S
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85164,823,807 - 164,836,729 (+)NCBIGRCr8
GRCr8 Ensembl5164,823,807 - 164,836,728 (+)EnsemblGRCr8 Ensembl
mRatBN7.25159,540,715 - 159,553,639 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5159,540,715 - 159,553,633 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5162,257,408 - 162,270,330 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05164,078,196 - 164,091,121 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05164,034,568 - 164,047,493 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05165,922,893 - 165,935,822 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5165,922,915 - 165,935,821 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05169,573,089 - 169,586,003 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45166,179,130 - 166,192,029 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera5157,811,683 - 157,824,582 (+)NCBICelera
RGSC_v3.15166,189,332 - 166,200,048 (+)NCBI
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-dexrazoxane  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,2-dichloroethane  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
[6]-Shogaol  (ISO)
aclacinomycin A  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
atrazine  (ISO)
benzene  (EXP)
benzo[a]pyrene  (EXP,ISO)
beta-naphthoflavone  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
capsaicin  (ISO)
carbamazepine  (ISO)
celecoxib  (ISO)
CGP 52608  (ISO)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
cyclosporin A  (ISO)
daunorubicin  (ISO)
decabromodiphenyl ether  (EXP)
deoxynivalenol  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (EXP,ISO)
Dibutyl phosphate  (ISO)
diclofenac  (ISO)
dimethyl sulfoxide  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
ellagic acid  (ISO)
embelin  (ISO)
enzyme inhibitor  (ISO)
equol  (ISO)
ethanol  (ISO)
fenamidone  (ISO)
folic acid  (ISO)
FR900359  (ISO)
furosemide  (EXP)
genistein  (ISO)
gentamycin  (EXP)
glyphosate  (ISO)
hydrogen peroxide  (EXP)
isoflurane  (EXP)
ivermectin  (ISO)
metformin  (ISO)
methyl methanesulfonate  (ISO)
Mitotane  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
nickel atom  (ISO)
Nutlin-3  (ISO)
ochratoxin A  (EXP)
oxybenzone  (EXP)
p-menthan-3-ol  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
Parthenin  (ISO)
pentobarbital  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
phenylmercury acetate  (ISO)
piroxicam  (ISO)
pterostilbene  (ISO)
pyrethrins  (ISO)
quercetin  (EXP,ISO)
resveratrol  (ISO)
SB 431542  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
sunitinib  (ISO)
T-2 toxin  (ISO)
temozolomide  (ISO)
titanium dioxide  (ISO)
triphenyl phosphate  (ISO)
usnic acid  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
VX nerve agent  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Characterization of the rat DNA fragmentation factor 35/Inhibitor of caspase-activated DNase (Short form). The endogenous inhibitor of caspase-dependent DNA fragmentation in neuronal apoptosis. Chen D, etal., J Biol Chem 2000 Dec 8;275(49):38508-17.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. GOA pipeline RGD automated data pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9108473   PMID:9564035   PMID:10601318   PMID:11371636   PMID:12477932   PMID:14663139   PMID:15572351   PMID:19882353   PMID:19944011   PMID:22253444  


Genomics

Comparative Map Data
Dffa
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85164,823,807 - 164,836,729 (+)NCBIGRCr8
GRCr8 Ensembl5164,823,807 - 164,836,728 (+)EnsemblGRCr8 Ensembl
mRatBN7.25159,540,715 - 159,553,639 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5159,540,715 - 159,553,633 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5162,257,408 - 162,270,330 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05164,078,196 - 164,091,121 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05164,034,568 - 164,047,493 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05165,922,893 - 165,935,822 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5165,922,915 - 165,935,821 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05169,573,089 - 169,586,003 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45166,179,130 - 166,192,029 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera5157,811,683 - 157,824,582 (+)NCBICelera
RGSC_v3.15166,189,332 - 166,200,048 (+)NCBI
Cytogenetic Map5q36NCBI
DFFA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38110,456,522 - 10,472,529 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl110,456,522 - 10,472,529 (-)EnsemblGRCh38hg38GRCh38
GRCh37110,516,579 - 10,532,586 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36110,443,175 - 10,455,200 (-)NCBINCBI36Build 36hg18NCBI36
Celera19,631,993 - 9,644,017 (-)NCBICelera
Cytogenetic Map1p36.22NCBI
HuRef19,674,182 - 9,686,174 (-)NCBIHuRef
CHM1_1110,508,330 - 10,520,370 (-)NCBICHM1_1
T2T-CHM13v2.0110,000,139 - 10,016,137 (-)NCBIT2T-CHM13v2.0
Dffa
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394149,188,599 - 149,205,110 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4149,188,603 - 149,205,104 (+)EnsemblGRCm39 Ensembl
GRCm384149,104,142 - 149,120,653 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4149,104,146 - 149,120,647 (+)EnsemblGRCm38mm10GRCm38
MGSCv374148,478,262 - 148,494,759 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364147,947,953 - 147,964,450 (+)NCBIMGSCv36mm8
Celera4151,371,738 - 151,386,868 (+)NCBICelera
Cytogenetic Map4E2NCBI
cM Map478.87NCBI
Dffa
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554863,273,712 - 3,274,510 (+)NCBIChiLan1.0ChiLan1.0
DFFA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21217,754,203 - 217,768,613 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11216,400,486 - 216,414,533 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v019,221,096 - 9,232,813 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1110,445,553 - 10,457,547 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl110,445,553 - 10,457,547 (-)Ensemblpanpan1.1panPan2
DFFA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1285,364,819 - 85,372,473 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl285,364,851 - 85,373,772 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha281,966,306 - 81,973,968 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0286,099,825 - 86,107,488 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl286,099,863 - 86,109,086 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1282,847,197 - 82,854,858 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0283,849,698 - 83,857,360 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0284,912,608 - 84,920,270 (+)NCBIUU_Cfam_GSD_1.0
Dffa
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505833,811,757 - 33,821,826 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366234,296,681 - 4,307,159 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366234,296,995 - 4,307,069 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DFFA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl670,724,590 - 70,736,236 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1670,725,403 - 70,736,264 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2664,658,250 - 64,669,091 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DFFA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120121,312,291 - 121,324,055 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20121,311,954 - 121,323,402 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605425,226,082 - 25,238,468 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dffa
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248182,225,777 - 2,239,897 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Dffa
65 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:568
Count of miRNA genes:265
Interacting mature miRNAs:357
Transcripts:ENSRNOT00000059522
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5130249266172190305Rat
1354583Despr3Despair related QTL34.980.0002locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)5132930505172190305Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5141212838172190305Rat
1300119Bp180Blood pressure QTL 1803.82arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5149642129171146538Rat
1549904Neuinf1Neuroinflammation QTL 130nervous system integrity trait (VT:0010566)blood T lymphocyte count (CMO:0000110)5160111176171146538Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)599905133172190305Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5133789363172190305Rat
1331803Rf32Renal function QTL 322.798kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)5134369199172190305Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)565089051166764498Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5136631198172190305Rat
1354631Swd2Spike wave discharge measurement QTL 23.640.0002brain electrophysiology trait (VT:0010557)brain total spike-and-wave discharge duration (CMO:0001740)5156396728172190305Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5133081618172190305Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)551657967166600247Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5138002522170842766Rat
1581505Rf54Renal function QTL 54kidney physiology trait (VT:0002136)kidney 20-HETE level (CMO:0001854)5133270647172190305Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5160071170172129029Rat
2317753Glom24Glomerulus QTL 243.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)5141764300172190305Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5133789363172190305Rat
1331721Bp210Blood pressure QTL 2103.413arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5148093485172129029Rat
1581510Cm54Cardiac mass QTL 543.40.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)5125969677172190305Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555124766172190305Rat
631272Lanf1Left ventricular atrial natriuretic factor QTL 112heart left ventricle natriuretic peptide A amount (VT:0010596)heart left ventricle natriuretic peptide A level (CMO:0002165)5156396728167181764Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5131708216172190305Rat
2313096Bmd78Bone mineral density QTL 783.10.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)5149661912166600247Rat
1298090Bp155Blood pressure QTL 1553.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)5156289283171137955Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5133081618172190305Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
9 11 49 113 91 90 59 25 59 6 218 97 11 93 45 60 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000059522   ⟹   ENSRNOP00000063043
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5164,823,818 - 164,836,728 (+)Ensembl
mRatBN7.2 Ensembl5159,540,715 - 159,553,633 (+)Ensembl
Rnor_6.0 Ensembl5165,922,923 - 165,935,821 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000089179   ⟹   ENSRNOP00000070485
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl5165,922,915 - 165,935,820 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000102581   ⟹   ENSRNOP00000094512
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5164,824,086 - 164,836,728 (+)Ensembl
mRatBN7.2 Ensembl5159,540,962 - 159,553,633 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000158286   ⟹   ENSRNOP00000104169
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5164,823,807 - 164,835,412 (+)Ensembl
RefSeq Acc Id: NM_001398977   ⟹   NP_001385906
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85164,823,807 - 164,836,729 (+)NCBI
mRatBN7.25159,540,715 - 159,553,639 (+)NCBI
RefSeq Acc Id: NM_053679   ⟹   NP_446131
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85164,823,807 - 164,836,729 (+)NCBI
mRatBN7.25159,540,715 - 159,553,639 (+)NCBI
Rnor_6.05165,922,923 - 165,935,822 (+)NCBI
Rnor_5.05169,573,089 - 169,586,003 (+)NCBI
RGSC_v3.45166,179,130 - 166,192,029 (+)RGD
Celera5157,811,683 - 157,824,582 (+)RGD
Sequence:
RefSeq Acc Id: NP_446131   ⟸   NM_053679
- Peptide Label: isoform 2
- UniProtKB: Q498U6 (UniProtKB/TrEMBL),   F7FCC9 (UniProtKB/TrEMBL),   Q9JLT3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000070485   ⟸   ENSRNOT00000089179
Ensembl Acc Id: ENSRNOP00000063043   ⟸   ENSRNOT00000059522
Ensembl Acc Id: ENSRNOP00000094512   ⟸   ENSRNOT00000102581
RefSeq Acc Id: NP_001385906   ⟸   NM_001398977
- Peptide Label: isoform 1
Ensembl Acc Id: ENSRNOP00000104169   ⟸   ENSRNOT00000158286
Protein Domains
CIDE-N

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JY18-F1-model_v2 AlphaFold A0A0G2JY18 1-328 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694268
Promoter ID:EPDNEW_R4793
Type:multiple initiation site
Name:Dffa_1
Description:DNA fragmentation factor subunit alpha
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05165,922,966 - 165,923,026EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620334 AgrOrtholog
BioCyc Gene G2FUF-39144 BioCyc
Ensembl Genes ENSRNOG00000013603 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000059522 ENTREZGENE
  ENSRNOT00000059522.3 UniProtKB/TrEMBL
  ENSRNOT00000102581.1 UniProtKB/TrEMBL
  ENSRNOT00000158286 ENTREZGENE
Gene3D-CATH 3.10.20.10 UniProtKB/TrEMBL
  C-terminal domain of DFF45/ICAD (DFF-C domain) UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7389030 IMAGE-MGC_LOAD
InterPro CAD UniProtKB/TrEMBL
  DFF-C_dom UniProtKB/TrEMBL
  DNA_fragmentation_C UniProtKB/TrEMBL
  DNA_fragmentation_factor_asu UniProtKB/TrEMBL
MGC_CLONE MGC:112608 IMAGE-MGC_LOAD
NCBI Gene 114214 ENTREZGENE
PANTHER CELL DEATH ACTIVATOR CIDE UniProtKB/TrEMBL
  PTHR12306:SF16 UniProtKB/TrEMBL
Pfam CIDE-N UniProtKB/TrEMBL
  DFF-C UniProtKB/TrEMBL
PhenoGen Dffa PhenoGen
PIRSF DFF_alpha UniProtKB/TrEMBL
PROSITE CIDE_N UniProtKB/TrEMBL
RatGTEx ENSRNOG00000013603 RatGTEx
SMART CAD UniProtKB/TrEMBL
Superfamily-SCOP CAD & PB1 domains UniProtKB/TrEMBL
  SSF81783 UniProtKB/TrEMBL
UniProt A0A8I6ANF5_RAT UniProtKB/TrEMBL
  F7FCC9 ENTREZGENE, UniProtKB/TrEMBL
  Q498U6 ENTREZGENE, UniProtKB/TrEMBL
  Q9JLT3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-26 Dffa  DNA fragmentation factor subunit alpha  Dffa  DNA fragmentation factor, alpha polypeptide  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-02-25 Dffa  DNA fragmentation factor, alpha polypeptide  Dffa  DNA fragmentation factor, alpha subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Dffa  DNA fragmentation factor, alpha subunit      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Dffa  DNA fragmentation factor, alpha subunit      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to the nucleus 632505
gene_physical_interaction forms a complex with DFF40/caspase-activated DNase (CAD) 632505