Dffb (DNA fragmentation factor subunit beta) - Rat Genome Database

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Gene: Dffb (DNA fragmentation factor subunit beta) Rattus norvegicus
Analyze
Symbol: Dffb
Name: DNA fragmentation factor subunit beta
RGD ID: 620335
Description: Enables DNA nuclease activity. Involved in apoptotic DNA fragmentation. Predicted to be located in cytosol; nucleolus; and nucleoplasm. Predicted to be part of chromatin. Biomarker of transient cerebral ischemia. Orthologous to human DFFB (DNA fragmentation factor subunit beta); PARTICIPATES IN apoptotic cell death pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Cad; caspase-activated deoxyribonuclease; caspase-activated DNase; DFF-40; DNA fragmentation factor 40 kD beta polypeptide (caspase-activated DNase); DNA fragmentation factor 40 kDa subunit; DNA fragmentation factor, 40 kD, beta polypeptide (caspase-activated DNase); DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase); DNA fragmentation factor, beta polypeptide (caspase-activated DNase); DNA fragmentation factor, beta subunit
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85169,804,873 - 169,817,157 (-)NCBIGRCr8
mRatBN7.25164,522,446 - 164,534,733 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5164,522,463 - 164,534,628 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5167,227,348 - 167,238,664 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05169,048,756 - 169,060,074 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05169,011,205 - 169,022,522 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05171,250,559 - 171,261,875 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5171,249,633 - 171,262,119 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05174,742,181 - 174,753,497 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45170,750,718 - 170,762,034 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15170,761,212 - 170,772,529 (-)NCBI
Celera5162,735,202 - 162,746,518 (-)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-alpha-phellandrene  (ISO)
(S)-nicotine  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,2-dimethylhydrazine  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-methylcholine  (ISO)
2-naphthylamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4-hydroxynon-2-enal  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
alpha-phellandrene  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
antimycin A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
azoxystrobin  (EXP,ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
chlorpyrifos  (EXP)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
deguelin  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
dichloroacetic acid  (ISO)
dicrotophos  (ISO)
diethylstilbestrol  (ISO)
disodium selenite  (ISO)
doxorubicin  (ISO)
fenpyroximate  (ISO)
fenvalerate  (EXP)
flavonoids  (EXP)
genistein  (ISO)
gentamycin  (EXP)
glyphosate  (EXP)
hydroquinone  (ISO)
imidacloprid  (EXP)
indometacin  (ISO)
irinotecan  (ISO)
isoprenaline  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
methotrexate  (ISO)
Mitotane  (EXP)
motexafin gadolinium  (ISO)
N-acetylsphingosine  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-ethyl-N-nitrosourea  (ISO)
nicotine  (ISO)
nitric oxide  (EXP)
ochratoxin A  (EXP)
p-menthan-3-ol  (ISO)
paracetamol  (EXP,ISO)
picoxystrobin  (ISO)
pirinixic acid  (ISO)
quercetin  (ISO)
reactive oxygen species  (ISO)
Roridin A  (ISO)
rotenone  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium dodecyl sulfate  (ISO)
sulindac  (ISO)
tebufenpyrad  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP)
thiabendazole  (EXP)
thiram  (ISO)
tributylstannane  (ISO)
trovafloxacin  (ISO)
valproic acid  (ISO)
vincaleukoblastine  (ISO)
zinc acetate  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
chromatin  (IEA,ISO)
cytoplasm  (IEA)
cytosol  (IEA,ISO)
nucleolus  (IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IEA,ISO)
protein-containing complex  (IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Nuclear Akt associates with PKC-phosphorylated Ebp1, preventing DNA fragmentation by inhibition of caspase-activated DNase. Ahn JY, etal., EMBO J. 2006 May 17;25(10):2083-95. Epub 2006 Apr 27.
2. Nucleophosmin/B23, a nuclear PI(3,4,5)P(3) receptor, mediates the antiapoptotic actions of NGF by inhibiting CAD. Ahn JY, etal., Mol Cell. 2005 May 13;18(4):435-45.
3. Caspase-activated DNase/DNA fragmentation factor 40 mediates apoptotic DNA fragmentation in transient cerebral ischemia and in neuronal cultures. Cao G, etal., J Neurosci 2001 Jul 1;21(13):4678-90.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. GOA pipeline RGD automated data pipeline
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9108473   PMID:10959840   PMID:11371636   PMID:12477932   PMID:15167901   PMID:15572351   PMID:15644269   PMID:16767516   PMID:18371080   PMID:19882353   PMID:19944011   PMID:22253444  


Genomics

Comparative Map Data
Dffb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85169,804,873 - 169,817,157 (-)NCBIGRCr8
mRatBN7.25164,522,446 - 164,534,733 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5164,522,463 - 164,534,628 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5167,227,348 - 167,238,664 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05169,048,756 - 169,060,074 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05169,011,205 - 169,022,522 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05171,250,559 - 171,261,875 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5171,249,633 - 171,262,119 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05174,742,181 - 174,753,497 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45170,750,718 - 170,762,034 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15170,761,212 - 170,772,529 (-)NCBI
Celera5162,735,202 - 162,746,518 (-)NCBICelera
Cytogenetic Map5q36NCBI
DFFB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3813,857,476 - 3,885,429 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl13,857,267 - 3,885,429 (+)EnsemblGRCh38hg38GRCh38
GRCh3713,774,040 - 3,801,993 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3613,763,705 - 3,791,853 (+)NCBINCBI36Build 36hg18NCBI36
Build 3413,797,001 - 3,825,149NCBI
Celera13,028,085 - 3,056,136 (+)NCBICelera
Cytogenetic Map1p36.32NCBI
HuRef13,069,403 - 3,097,689 (+)NCBIHuRef
CHM1_113,760,848 - 3,789,006 (+)NCBICHM1_1
T2T-CHM13v2.013,369,074 - 3,397,333 (+)NCBIT2T-CHM13v2.0
Dffb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394154,048,904 - 154,059,578 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4154,048,906 - 154,059,583 (-)EnsemblGRCm39 Ensembl
GRCm384153,964,447 - 153,975,121 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4153,964,449 - 153,975,126 (-)EnsemblGRCm38mm10GRCm38
MGSCv374153,338,558 - 153,349,190 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364152,808,255 - 152,818,926 (-)NCBIMGSCv36mm8
Celera4156,252,603 - 156,263,261 (-)NCBICelera
Cytogenetic Map4E2NCBI
cM Map483.78NCBI
Dffb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554867,838,273 - 7,850,180 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554867,836,013 - 7,849,875 (-)NCBIChiLan1.0ChiLan1.0
DFFB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21224,411,057 - 224,450,359 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11223,052,777 - 223,094,130 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012,529,733 - 2,559,490 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.113,649,723 - 3,676,896 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl13,649,729 - 3,676,896 (+)Ensemblpanpan1.1panPan2
DFFB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1558,340,183 - 58,355,353 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl558,339,634 - 58,354,326 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha558,350,476 - 58,365,648 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0558,547,681 - 58,562,856 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl558,547,687 - 58,562,863 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1558,555,388 - 58,570,554 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0558,424,285 - 58,439,461 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0558,814,557 - 58,829,729 (+)NCBIUU_Cfam_GSD_1.0
Dffb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505829,369,795 - 29,385,848 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493673781,078 - 96,151 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493673779,789 - 96,140 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DFFB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl665,310,864 - 65,323,806 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1665,310,868 - 65,323,816 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2660,157,486 - 60,164,636 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DFFB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120127,800,351 - 127,823,512 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605431,993,772 - 32,025,522 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dffb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248186,700,050 - 6,712,450 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248186,700,120 - 6,712,449 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Dffb
15 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:146
Count of miRNA genes:102
Interacting mature miRNAs:121
Transcripts:ENSRNOT00000032825
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5124965598166875058Rat
631272Lanf1Left ventricular atrial natriuretic factor QTL 112heart left ventricle natriuretic peptide A amount (VT:0010596)heart left ventricle natriuretic peptide A level (CMO:0002165)5151113452166875058Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
631562Apr2Acute phase response QTL 23.7blood murinoglobulin 1 amount (VT:0010597)plasma murinoglobulin 1 level (CMO:0001931)5135927956166875058Rat
634349Bp139Blood pressure QTL 1390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5128924607166875058Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5135929696166875058Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5126424772166875058Rat
1549904Neuinf1Neuroinflammation QTL 130nervous system integrity trait (VT:0010566)blood T lymphocyte count (CMO:0000110)5154828214166875058Rat
738018Anxrr4Anxiety related response QTL 45.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)5130130159166875058Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5128506074166875058Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5131345754166875058Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5127798274166875058Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5132717196165560427Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5121846814166846814Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5127798274166875058Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5128506074166875058Rat
1331721Bp210Blood pressure QTL 2103.413arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5143069996166846814Rat

Markers in Region
BE121446  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25164,523,052 - 164,523,215 (+)MAPPERmRatBN7.2
Rnor_6.05171,250,375 - 171,250,537NCBIRnor6.0
Rnor_5.05174,741,997 - 174,742,159UniSTSRnor5.0
RGSC_v3.45170,750,534 - 170,750,696UniSTSRGSC3.4
Celera5162,735,018 - 162,735,180UniSTS
RH 3.4 Map51142.0UniSTS
Cytogenetic Map5q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000032825   ⟹   ENSRNOP00000034722
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5164,522,677 - 164,534,628 (-)Ensembl
Rnor_6.0 Ensembl5171,249,633 - 171,262,119 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000105778   ⟹   ENSRNOP00000096977
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5164,522,463 - 164,534,539 (-)Ensembl
RefSeq Acc Id: NM_053362   ⟹   NP_445814
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85169,805,664 - 169,816,980 (-)NCBI
mRatBN7.25164,523,237 - 164,534,553 (-)NCBI
Rnor_6.05171,250,559 - 171,261,875 (-)NCBI
Rnor_5.05174,742,181 - 174,753,497 (-)NCBI
RGSC_v3.45170,750,718 - 170,762,034 (-)RGD
Celera5162,735,202 - 162,746,518 (-)RGD
Sequence:
RefSeq Acc Id: XM_039110874   ⟹   XP_038966802
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85169,804,873 - 169,817,157 (-)NCBI
mRatBN7.25164,522,446 - 164,534,733 (-)NCBI
RefSeq Acc Id: XM_063288499   ⟹   XP_063144569
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85169,804,873 - 169,817,157 (-)NCBI
RefSeq Acc Id: XM_063288500   ⟹   XP_063144570
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85169,804,873 - 169,817,157 (-)NCBI
RefSeq Acc Id: XR_005504541
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85169,806,134 - 169,817,157 (-)NCBI
mRatBN7.25164,522,446 - 164,534,733 (-)NCBI
RefSeq Acc Id: XR_005504543
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85169,811,107 - 169,817,157 (-)NCBI
mRatBN7.25164,528,681 - 164,534,733 (-)NCBI
RefSeq Acc Id: XR_005504544
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85169,811,943 - 169,817,157 (-)NCBI
mRatBN7.25164,529,516 - 164,534,733 (-)NCBI
RefSeq Acc Id: NP_445814   ⟸   NM_053362
- UniProtKB: Q99N34 (UniProtKB/Swiss-Prot),   A0A8I6AS11 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000034722   ⟸   ENSRNOT00000032825
RefSeq Acc Id: XP_038966802   ⟸   XM_039110874
- Peptide Label: isoform X1
- UniProtKB: A0A0H2UHU4 (UniProtKB/TrEMBL),   A6IUJ9 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000096977   ⟸   ENSRNOT00000105778
RefSeq Acc Id: XP_063144570   ⟸   XM_063288500
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063144569   ⟸   XM_063288499
- Peptide Label: isoform X2
Protein Domains
CIDE-N

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q99N34-F1-model_v2 AlphaFold Q99N34 1-349 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620335 AgrOrtholog
BioCyc Gene G2FUF-38975 BioCyc
Ensembl Genes ENSRNOG00000025030 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000032825.6 UniProtKB/TrEMBL
  ENSRNOT00000105778.1 UniProtKB/TrEMBL
Gene3D-CATH 3.10.20.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  6.10.140.170 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro CIDE-N_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DFF40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DFF40_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  His-Me_finger_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:84359 UniProtKB/Swiss-Prot
NCBI Gene 84359 ENTREZGENE
PANTHER CASPASE-ACTIVATED DNASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR13067 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam CIDE-N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DFF40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Dffb PhenoGen
PROSITE CIDE_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000025030 RatGTEx
SMART CAD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP CAD & PB1 domains UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF54060 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0H2UHU4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AS11 ENTREZGENE, UniProtKB/TrEMBL
  A6IUJ9 ENTREZGENE, UniProtKB/TrEMBL
  DFFB_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Dffb  DNA fragmentation factor subunit beta  Dffb  DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-01-10 Dffb  DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)  Dffb  DNA fragmentation factor, beta polypeptide (caspase-activated DNase)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-26 Dffb  DNA fragmentation factor, beta polypeptide (caspase-activated DNase)  Dffb  DNA fragmentation factor, beta subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Dffb  DNA fragmentation factor, beta subunit    DNA fragmentation factor, 40 kD, beta polypeptide (caspase-activated DNase)  Name updated 1299863 APPROVED
2002-08-07 Dffb  DNA fragmentation factor, 40 kD, beta polypeptide (caspase-activated DNase)      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_domains contains a probable nuclear localization segment stretch of 20 amino acid stretch and a N terminal cysteine residue stretch acting as heterodimerization component 628524
gene_expression highest mRNA expression in intestine and medium expression in the spleen, lung, kidney, liver, testis, heart and brain; low expression in stomach an skeletal muscle 628524
gene_expression ~4.5 fold higher cerebellar expression in 17-d-old embryos and 1- and 2-week-old newborns than adults 628524
gene_function caspase-3 activated endogenous deoxyribonuclease 628524
gene_homology has 73% and 94% identity to human and mouse genes, respectively 628524
gene_pathway active in neuronal apoptotic pathway 628524
gene_physical_interaction forms a heterodimeric complex with caspase-activated deoxyribonuclease (CAD) in the nucleus 628524
gene_process promotes apoptotic internucleosomal DNA degradation 628524
gene_process promotes DNA degradations related nuclear alterations in ischemic neurons 628524
gene_regulation DNA degradation inhibited by ICAD prtein levels 628524
gene_regulation activated by caspase-3 and induced after ischemia 628524