Slc45a1 (solute carrier family 45, member 1) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Slc45a1 (solute carrier family 45, member 1) Rattus norvegicus
Analyze
Symbol: Slc45a1
Name: solute carrier family 45, member 1
RGD ID: 708502
Description: Enables galactose:proton symporter activity and glucose:proton symporter activity. Involved in galactose transmembrane transport and glucose transmembrane transport. Predicted to be active in membrane. Orthologous to human SLC45A1 (solute carrier family 45 member 1); INTERACTS WITH 1,3-dinitrobenzene; 2,3,7,8-tetrachlorodibenzodioxine; ammonium chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Dnb5; Past-A; Pasta; proton-associated sugar transporter A; solute carrier family 45 member 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25161,105,137 - 161,129,375 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5161,105,235 - 161,129,303 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5163,821,902 - 163,846,153 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05165,641,057 - 165,665,239 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05165,600,544 - 165,624,787 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05167,672,134 - 167,696,331 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5167,672,145 - 167,696,348 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05171,299,997 - 171,322,391 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45167,784,827 - 167,807,254 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15167,795,015 - 167,817,442 (-)NCBI
Celera5159,360,991 - 159,384,477 (-)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
membrane  (IBA,IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Past-A, a novel proton-associated sugar transporter, regulates glucose homeostasis in the brain. Shimokawa N, etal., J Neurosci 2002 Nov 1;22(21):9160-5.
6. Dysfunction of the Cerebral Glucose Transporter SLC45A1 in Individuals with Intellectual Disability and Epilepsy. Srour M, etal., Am J Hum Genet. 2017 May 4;100(5):824-830. doi: 10.1016/j.ajhg.2017.03.009. Epub 2017 Apr 20.
Additional References at PubMed
PMID:12477932  


Genomics

Comparative Map Data
Slc45a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25161,105,137 - 161,129,375 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5161,105,235 - 161,129,303 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5163,821,902 - 163,846,153 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05165,641,057 - 165,665,239 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05165,600,544 - 165,624,787 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05167,672,134 - 167,696,331 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5167,672,145 - 167,696,348 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05171,299,997 - 171,322,391 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45167,784,827 - 167,807,254 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15167,795,015 - 167,817,442 (-)NCBI
Celera5159,360,991 - 159,384,477 (-)NCBICelera
Cytogenetic Map5q36NCBI
SLC45A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3818,318,114 - 8,344,165 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl18,318,114 - 8,344,167 (+)EnsemblGRCh38hg38GRCh38
GRCh3718,378,174 - 8,404,225 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3618,306,977 - 8,326,814 (+)NCBINCBI36Build 36hg18NCBI36
Build 3418,324,463 - 8,338,480NCBI
Celera17,492,236 - 7,512,007 (+)NCBICelera
Cytogenetic Map1p36.23NCBI
HuRef17,532,573 - 7,552,503 (+)NCBIHuRef
CHM1_118,373,365 - 8,393,233 (+)NCBICHM1_1
T2T-CHM13v2.017,849,807 - 7,876,669 (+)NCBIT2T-CHM13v2.0
Slc45a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394150,713,853 - 150,736,614 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4150,713,029 - 150,736,631 (-)EnsemblGRCm39 Ensembl
GRCm384150,629,396 - 150,652,176 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4150,628,572 - 150,652,174 (-)EnsemblGRCm38mm10GRCm38
MGSCv374150,003,505 - 150,026,283 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364149,473,196 - 149,495,974 (-)NCBIMGSCv36mm8
Celera4152,906,467 - 152,928,714 (-)NCBICelera
Cytogenetic Map4E2NCBI
cM Map481.44NCBI
Slc45a1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554864,701,991 - 4,716,939 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554864,701,889 - 4,732,008 (-)NCBIChiLan1.0ChiLan1.0
SLC45A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan11218,531,186 - 218,559,560 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v017,071,109 - 7,102,698 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.118,314,224 - 8,340,248 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl18,314,224 - 8,340,248 (+)Ensemblpanpan1.1panPan2
SLC45A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1561,838,062 - 61,861,411 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl561,841,451 - 61,862,421 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha561,847,107 - 61,870,449 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0562,054,673 - 62,078,223 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl562,058,118 - 62,078,213 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1562,053,637 - 62,077,147 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0561,918,239 - 61,941,521 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0562,322,460 - 62,345,778 (+)NCBIUU_Cfam_GSD_1.0
Slc45a1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505832,169,174 - 32,186,762 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366232,658,897 - 2,673,024 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366232,658,996 - 2,671,993 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC45A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl668,933,912 - 68,950,530 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1668,933,918 - 68,950,534 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2663,294,889 - 63,417,949 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SLC45A1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120123,416,912 - 123,443,016 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20123,416,882 - 123,442,548 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605427,445,462 - 27,471,412 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc45a1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248183,654,007 - 3,665,579 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248183,653,999 - 3,669,433 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Slc45a1
173 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:66
Count of miRNA genes:63
Interacting mature miRNAs:66
Transcripts:ENSRNOT00000024581
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5121846814166846814Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5124965598166875058Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5126424772166875058Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5127798274166875058Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5127798274166875058Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5128506074166875058Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5128506074166875058Rat
634349Bp139Blood pressure QTL 1390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5128924607166875058Rat
738018Anxrr4Anxiety related response QTL 45.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)5130130159166875058Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5131345754166875058Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5132717196165560427Rat
631562Apr2Acute phase response QTL 23.7blood murinoglobulin 1 amount (VT:0010597)plasma murinoglobulin 1 level (CMO:0001931)5135927956166875058Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5135929696166875058Rat
1331721Bp210Blood pressure QTL 2103.413arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5143069996166846814Rat
2302369Scl60Serum cholesterol level QTL 603.13blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)5143608201161165651Rat
2313096Bmd78Bone mineral density QTL 783.10.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)5144377876161317411Rat
1298090Bp155Blood pressure QTL 1553.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)5151006154161165494Rat
1354631Swd2Spike wave discharge measurement QTL 23.640.0002brain electrophysiology trait (VT:0010557)brain total spike-and-wave discharge duration (CMO:0001740)5151113452164465185Rat
631272Lanf1Left ventricular atrial natriuretic factor QTL 112heart left ventricle natriuretic peptide A amount (VT:0010596)heart left ventricle natriuretic peptide A level (CMO:0002165)5151113452166875058Rat
1549904Neuinf1Neuroinflammation QTL 130nervous system integrity trait (VT:0010566)blood T lymphocyte count (CMO:0000110)5154828214166875058Rat

Markers in Region
SHGC-74183  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25161,095,599 - 161,095,773 (+)MAPPERmRatBN7.2
Rnor_6.05167,662,428 - 167,662,601NCBIRnor6.0
Rnor_5.05171,290,435 - 171,290,608UniSTSRnor5.0
RGSC_v3.45167,775,193 - 167,775,366UniSTSRGSC3.4
Celera5159,351,438 - 159,351,611UniSTS
Cytogenetic Map5q36UniSTS
BI276205  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25161,095,586 - 161,095,767 (+)MAPPERmRatBN7.2
Rnor_6.05167,662,415 - 167,662,595NCBIRnor6.0
Rnor_5.05171,290,422 - 171,290,602UniSTSRnor5.0
RGSC_v3.45167,775,180 - 167,775,360UniSTSRGSC3.4
Celera5159,351,425 - 159,351,605UniSTS
RH 3.4 Map51122.6UniSTS
Cytogenetic Map5q36UniSTS
BE095521  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25161,120,136 - 161,120,338 (+)MAPPERmRatBN7.2
Rnor_6.05167,686,989 - 167,687,190NCBIRnor6.0
Rnor_5.05171,314,179 - 171,314,380UniSTSRnor5.0
RGSC_v3.45167,798,092 - 167,798,293UniSTSRGSC3.4
Celera5159,375,721 - 159,375,922UniSTS
RH 3.4 Map51121.4UniSTS
Cytogenetic Map5q36UniSTS
AI548909  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25161,097,434 - 161,097,524 (+)MAPPERmRatBN7.2
Rnor_6.05167,664,263 - 167,664,352NCBIRnor6.0
Rnor_5.05171,292,270 - 171,292,359UniSTSRnor5.0
RGSC_v3.45167,777,028 - 167,777,117UniSTSRGSC3.4
Celera5159,353,273 - 159,353,362UniSTS
RH 3.4 Map51121.7UniSTS
Cytogenetic Map5q36UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 64
Low 2 2 2 10 6 36
Below cutoff 3 32 24 8 17 8 4 6 17 5 11 4

Sequence


RefSeq Acc Id: ENSRNOT00000024581   ⟹   ENSRNOP00000024581
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5161,105,235 - 161,129,303 (-)Ensembl
Rnor_6.0 Ensembl5167,672,145 - 167,696,348 (-)Ensembl
RefSeq Acc Id: NM_144747   ⟹   NP_653348
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25161,105,235 - 161,129,303 (-)NCBI
Rnor_6.05167,672,134 - 167,696,331 (-)NCBI
Rnor_5.05171,299,997 - 171,322,391 (-)NCBI
RGSC_v3.45167,784,827 - 167,807,254 (-)RGD
Celera5159,360,991 - 159,384,477 (-)RGD
Sequence:
RefSeq Acc Id: XM_039109269   ⟹   XP_038965197
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25161,105,137 - 161,129,375 (-)NCBI
RefSeq Acc Id: XM_039109270   ⟹   XP_038965198
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25161,105,137 - 161,121,010 (-)NCBI
Protein Sequences
Protein RefSeqs NP_653348 (Get FASTA)   NCBI Sequence Viewer  
  XP_038965197 (Get FASTA)   NCBI Sequence Viewer  
  XP_038965198 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH93599 (Get FASTA)   NCBI Sequence Viewer  
  BAB97313 (Get FASTA)   NCBI Sequence Viewer  
  EDL81189 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000024581
  ENSRNOP00000024581.6
GenBank Protein Q8K4S3 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_653348   ⟸   NM_144747
- UniProtKB: A0A0G2QC36 (UniProtKB/TrEMBL),   Q566E3 (UniProtKB/TrEMBL),   A6IUD8 (UniProtKB/TrEMBL),   F1LNK7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000024581   ⟸   ENSRNOT00000024581
RefSeq Acc Id: XP_038965197   ⟸   XM_039109269
- Peptide Label: isoform X1
- UniProtKB: A0A0G2QC36 (UniProtKB/TrEMBL),   A6IUD8 (UniProtKB/TrEMBL),   F1LNK7 (UniProtKB/TrEMBL),   Q566E3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038965198   ⟸   XM_039109270
- Peptide Label: isoform X2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8K4S3-F1-model_v2 AlphaFold Q8K4S3 1-751 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:708502 AgrOrtholog
BioCyc Gene G2FUF-39065 BioCyc
Ensembl Genes ENSRNOG00000018229 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000024581 ENTREZGENE
  ENSRNOT00000024581.8 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1250.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7315729 IMAGE-MGC_LOAD
InterPro MFS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MFS_trans_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:246258 UniProtKB/TrEMBL
MGC_CLONE MGC:105314 IMAGE-MGC_LOAD
NCBI Gene 246258 ENTREZGENE
PANTHER PROTON-ASSOCIATED SUGAR TRANSPORTER A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SUGAR TRANSPORTER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam MFS_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Slc45a1 PhenoGen
RatGTEx ENSRNOG00000018229 RatGTEx
Superfamily-SCOP SSF103473 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2QC36 ENTREZGENE, UniProtKB/TrEMBL
  A6IUD8 ENTREZGENE, UniProtKB/TrEMBL
  F1LNK7 ENTREZGENE
  Q566E3 ENTREZGENE, UniProtKB/TrEMBL
  Q8K4S3 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary F1LNK7 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Slc45a1  solute carrier family 45, member 1  Dnb5  proton-associated sugar transporter A  Symbol and Name updated 1299863 APPROVED
2004-09-10 Dnb5  proton-associated sugar transporter A  Pasta    Symbol and Name updated 1299863 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains contains 12 putative membrane-spanning helices with a long cytoplasmic loop between TM6 and TM7 and with intracellular orientation of N and C termini 628346
gene_domains sequence motifs critical for the sugar transport function are RFGRR between TM2 and TM3, RG between TM4 and TM5, PERP motif after helix 6, and WLS motif in TM helix 7 628346
gene_expression highly enriched in brain 628346
gene_expression mRNA is expressed highly in the ventral medullary surface (VMS) and moderately in the cerebral cortex and cerebellum 628346
gene_process mediates glucose uptake along the pH gradient 628346
gene_product member of a novel class of mammalian sugar transporter 628346
gene_protein 751 amino acids; 82 kDa 628346
gene_regulation increases after hypercapnia 628346
gene_regulation glucose transport activity is controlled by the pH gradient 628346