Rnf223 (ring finger protein 223) - Rat Genome Database

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Gene: Rnf223 (ring finger protein 223) Rattus norvegicus
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Symbol: Rnf223
Name: ring finger protein 223
RGD ID: 1587009
Description: Predicted to enable metal ion binding activity. Predicted to be located in membrane. Orthologous to human RNF223 (ring finger protein 223); INTERACTS WITH 17beta-estradiol (ortholog); 2-hydroxypropanoic acid (ortholog); chlordecone (ortholog).
Type: protein-coding
RefSeq Status: INFERRED
Previously known as: AC097183.1; hypothetical protein LOC680874; LOC680874
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85172,005,566 - 172,008,456 (+)NCBIGRCr8
mRatBN7.25166,723,346 - 166,726,236 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5166,724,984 - 166,725,751 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5169,425,360 - 169,428,250 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05171,246,793 - 171,249,683 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05171,209,321 - 171,212,211 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05173,561,016 - 173,566,844 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5173,565,512 - 173,566,356 (+)NCBIRnor6.0rn6Rnor6.0
Rnor_5.05177,034,903 - 177,040,731 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45172,973,806 - 172,976,353 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera5164,920,233 - 164,926,061 (+)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
membrane  (IEA)

Molecular Function

References

Genomics

Comparative Map Data
Rnf223
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85172,005,566 - 172,008,456 (+)NCBIGRCr8
mRatBN7.25166,723,346 - 166,726,236 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5166,724,984 - 166,725,751 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5169,425,360 - 169,428,250 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05171,246,793 - 171,249,683 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05171,209,321 - 171,212,211 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05173,561,016 - 173,566,844 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5173,565,512 - 173,566,356 (+)NCBIRnor6.0rn6Rnor6.0
Rnor_5.05177,034,903 - 177,040,731 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45172,973,806 - 172,976,353 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera5164,920,233 - 164,926,061 (+)NCBICelera
Cytogenetic Map5q36NCBI
RNF223
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811,070,967 - 1,074,306 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11,070,967 - 1,074,306 (-)EnsemblGRCh38hg38GRCh38
GRCh3711,006,347 - 1,009,686 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361997,060 - 1,000,102 (-)NCBINCBI36Build 36hg18NCBI36
Celera11,574,564 - 1,577,125 (+)NCBICelera
Cytogenetic Map1p36.33NCBI
HuRef1279,266 - 281,827 (-)NCBIHuRef
CHM1_11994,157 - 996,718 (-)NCBICHM1_1
T2T-CHM13v2.01501,061 - 504,400 (-)NCBIT2T-CHM13v2.0
Rnf223
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394156,214,972 - 156,217,874 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4156,214,970 - 156,217,877 (+)EnsemblGRCm39 Ensembl
GRCm384156,130,515 - 156,133,417 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4156,130,513 - 156,133,420 (+)EnsemblGRCm38mm10GRCm38
MGSCv374155,116,903 - 155,122,956 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364155,116,903 - 155,122,956 (+)NCBIMGSCv36mm8
Celera4158,389,597 - 158,395,650 (+)NCBICelera
Cytogenetic Map4E2NCBI
cM Map488.44NCBI
Rnf223
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554869,662,186 - 9,665,467 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554869,658,706 - 9,665,467 (+)NCBIChiLan1.0ChiLan1.0
RNF223
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21227,178,971 - 227,182,246 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11225,874,504 - 225,877,768 (+)NCBINHGRI_mPanPan1
PanPan1.11983,724 - 986,432 (-)NCBIpanpan1.1PanPan1.1panPan2
RNF223
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1556,290,548 - 56,293,473 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha556,367,522 - 56,370,310 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0556,493,042 - 56,495,831 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl556,493,047 - 56,499,637 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1556,484,072 - 56,486,861 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0556,376,396 - 56,379,185 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0556,766,219 - 56,769,008 (-)NCBIUU_Cfam_GSD_1.0
Rnf223
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505827,468,149 - 27,474,753 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049367371,992,117 - 1,997,810 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RNF223
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl663,413,086 - 63,414,357 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1663,413,080 - 63,445,277 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2657,819,767 - 57,829,331 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RNF223
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120130,359,448 - 130,365,430 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20130,364,349 - 130,365,098 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605434,979,407 - 34,992,078 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rnf223
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248188,461,575 - 8,467,038 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248188,461,662 - 8,467,044 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Rnf223
15 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631272Lanf1Left ventricular atrial natriuretic factor QTL 112heart left ventricle natriuretic peptide A amount (VT:0010596)heart left ventricle natriuretic peptide A level (CMO:0002165)5151113452166875058Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5124965598166875058Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
631562Apr2Acute phase response QTL 23.7blood murinoglobulin 1 amount (VT:0010597)plasma murinoglobulin 1 level (CMO:0001931)5135927956166875058Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5135929696166875058Rat
634349Bp139Blood pressure QTL 1390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5128924607166875058Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5126424772166875058Rat
1549904Neuinf1Neuroinflammation QTL 130nervous system integrity trait (VT:0010566)blood T lymphocyte count (CMO:0000110)5154828214166875058Rat
738018Anxrr4Anxiety related response QTL 45.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)5130130159166875058Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5128506074166875058Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5131345754166875058Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5127798274166875058Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5121846814166846814Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5127798274166875058Rat
1331721Bp210Blood pressure QTL 2103.413arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5143069996166846814Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5128506074166875058Rat

Markers in Region
RH144414  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25166,725,811 - 166,726,098 (+)MAPPERmRatBN7.2
Rnor_6.05173,566,420 - 173,566,706NCBIRnor6.0
Rnor_5.05177,040,307 - 177,040,593UniSTSRnor5.0
RGSC_v3.45172,975,929 - 172,976,215UniSTSRGSC3.4
Celera5164,925,637 - 164,925,923UniSTS
RH 3.4 Map51171.5UniSTS
Cytogenetic Map5q36UniSTS


Expression


Sequence


Ensembl Acc Id: ENSRNOT00000055314   ⟹   ENSRNOP00000077995
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5166,724,984 - 166,725,751 (+)Ensembl
RefSeq Acc Id: NM_001398967   ⟹   NP_001385896
RefSeq Status: INFERRED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85172,005,566 - 172,008,456 (+)NCBI
mRatBN7.25166,723,346 - 166,726,236 (+)NCBI
RefSeq Acc Id: XM_039111398   ⟹   XP_038967326
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85172,005,861 - 172,008,456 (+)NCBI
mRatBN7.25166,723,656 - 166,726,236 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001385896 (Get FASTA)   NCBI Sequence Viewer  
  XP_038967326 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000077995.1
RefSeq Acc Id: XP_038967326   ⟸   XM_039111398
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000077995   ⟸   ENSRNOT00000055314
RefSeq Acc Id: NP_001385896   ⟸   NM_001398967
- UniProtKB: A0A8I5Y6Y6 (UniProtKB/TrEMBL)
Protein Domains
RING-type

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1587009 AgrOrtholog
BioCyc Gene G2FUF-38862 BioCyc
Ensembl Genes ENSRNOG00000036856 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000055314.5 UniProtKB/TrEMBL
Gene3D-CATH 3.30.40.10 UniProtKB/TrEMBL
InterPro RING_finger_E3_ubiq-ligases UniProtKB/TrEMBL
  Znf-RING_euk UniProtKB/TrEMBL
  Znf_RING UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/TrEMBL
  Znf_RING_CS UniProtKB/TrEMBL
NCBI Gene 680874 ENTREZGENE
PANTHER RING FINGER PROTEIN 223 UniProtKB/TrEMBL
  UNCHARACTERIZED UniProtKB/TrEMBL
Pfam zf-RING_UBOX UniProtKB/TrEMBL
PhenoGen Rnf223 PhenoGen
PROSITE ZF_RING_1 UniProtKB/TrEMBL
  ZF_RING_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000036856 RatGTEx
SMART RING UniProtKB/TrEMBL
Superfamily-SCOP RING/U-box UniProtKB/TrEMBL
UniProt A0A8I5Y6Y6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-02 Rnf223  ring finger protein 223  AC097183.1    Data merged from RGD:15004225 737654 PROVISIONAL
2019-11-08 AC097183.1        Symbol and Name status set to provisional 45752 PROVISIONAL
2013-08-09 Rnf223  ring finger protein 223  LOC680874  hypothetical protein LOC680874  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-01-09 LOC680874  hypothetical protein LOC680874  LOC687293  hypothetical protein LOC687293  Data merged from RGD:1587686 1643240 APPROVED
2006-11-19 LOC680874  hypothetical protein LOC680874      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC687293  hypothetical protein LOC687293      Symbol and Name status set to provisional 70820 PROVISIONAL