Hes5 (hes family bHLH transcription factor 5) - Rat Genome Database

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Pathways
Gene: Hes5 (hes family bHLH transcription factor 5) Rattus norvegicus
Analyze
Symbol: Hes5
Name: hes family bHLH transcription factor 5
RGD ID: 621340
Description: Enables chromatin binding activity and double-stranded DNA binding activity. Involved in several processes, including generation of neurons; negative regulation of cell differentiation; and neuronal stem cell population maintenance. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Biomarker of diabetes mellitus. Orthologous to human HES5 (hes family bHLH transcription factor 5); PARTICIPATES IN Notch signaling pathway; Notch signaling pathway; INTERACTS WITH 2,2',4,4',5,5'-hexachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: hairy and enhancer of split 5; hairy and enhancer of split 5 (Drosophila); transcription factor HES-5
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85170,804,511 - 170,807,988 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5170,803,940 - 170,806,021 (+)EnsemblGRCr8
mRatBN7.25165,522,138 - 165,523,684 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5165,522,234 - 165,523,001 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5168,227,682 - 168,228,449 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05170,049,096 - 170,049,863 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05170,011,628 - 170,012,395 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05172,364,421 - 172,365,188 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5172,364,421 - 172,365,188 (+)Ensemblrn6Rnor6.0
Rnor_5.05175,820,392 - 175,821,159 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45171,763,869 - 171,764,636 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5163,728,713 - 163,729,480 (+)NCBICelera
RGSC_v3.15171,774,363 - 171,775,131 (+)NCBI
Cytogenetic Map5q36NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-amphetamine  (ISO)
1,2-dimethylhydrazine  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acetaldehyde  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
antimycin A  (ISO)
Aroclor 1254  (EXP)
arotinoid acid  (ISO)
arsenous acid  (ISO)
avobenzone  (ISO)
azoxystrobin  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (EXP,ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
carbamazepine  (ISO)
CHIR 99021  (ISO)
clofibrate  (ISO)
cortisol  (ISO)
crocidolite asbestos  (ISO)
Cyclopamine  (EXP)
cyclophosphamide  (ISO)
cytarabine  (ISO)
diarsenic trioxide  (ISO)
dorsomorphin  (ISO)
entinostat  (ISO)
Evodiamine  (ISO)
flavonoids  (EXP)
fluoxetine  (EXP)
folic acid  (EXP)
glycidol  (EXP)
glyphosate  (ISO)
iron dichloride  (ISO)
ketamine  (EXP)
L-ascorbic acid  (ISO)
L-ascorbic acid 2-phosphate  (ISO)
mercury dibromide  (ISO)
methamphetamine  (EXP)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
ochratoxin A  (EXP)
p-chloromercuribenzoic acid  (ISO)
panobinostat  (ISO)
paracetamol  (ISO)
phenylmercury acetate  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (EXP)
poly(ethylene)  (ISO)
progesterone  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
SCH 23390  (EXP)
silicon dioxide  (ISO)
simvastatin  (EXP)
sodium arsenite  (ISO)
Soman  (EXP)
tebufenpyrad  (ISO)
thifluzamide  (ISO)
thyroxine  (EXP)
toluene  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
valproic acid  (EXP,ISO)
vorinostat  (ISO)
XAV939  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ development  (IEA)
anterior/posterior pattern specification  (IBA)
astrocyte differentiation  (ISO,ISS)
BMP signaling pathway  (ISO)
brain development  (ISO,ISS)
camera-type eye development  (ISO,ISS)
cartilage development  (ISO,ISS)
cell adhesion  (ISO,ISS)
cell differentiation  (IEA)
cell maturation  (ISO,ISS)
central nervous system myelination  (ISO,ISS)
central nervous system neuron differentiation  (ISO)
chondrocyte differentiation  (ISO,ISS)
comma-shaped body morphogenesis  (ISO)
establishment of epithelial cell polarity  (ISO)
forebrain radial glial cell differentiation  (IDA)
glial cell fate commitment  (ISO,ISS)
inner ear auditory receptor cell differentiation  (ISO)
inner ear receptor cell stereocilium organization  (ISO)
metanephric nephron tubule morphogenesis  (ISO)
negative regulation of astrocyte differentiation  (ISO,ISS)
negative regulation of cell differentiation  (IEA)
negative regulation of DNA-templated transcription  (IDA,ISO)
negative regulation of forebrain neuron differentiation  (IDA)
negative regulation of inner ear auditory receptor cell differentiation  (ISO)
negative regulation of inner ear receptor cell differentiation  (ISO)
negative regulation of neuron differentiation  (ISO,ISS)
negative regulation of oligodendrocyte differentiation  (ISO,ISS)
negative regulation of pro-B cell differentiation  (IMP)
negative regulation of stem cell differentiation  (ISO,ISS)
negative regulation of transcription by RNA polymerase II  (IDA,ISO)
nervous system development  (IEA)
neural tube development  (ISO,ISS)
neuron differentiation  (IEP,ISO)
neuronal stem cell population maintenance  (IDA,IEA,ISO)
Notch signaling pathway  (ISO,ISS)
oligodendrocyte development  (ISO,ISS)
oligodendrocyte differentiation  (ISO)
positive regulation of BMP signaling pathway  (ISO,ISS)
positive regulation of cell population proliferation  (ISO,ISS)
positive regulation of DNA-templated transcription  (ISO,ISS)
positive regulation of Notch signaling pathway  (ISO)
positive regulation of receptor signaling pathway via JAK-STAT  (ISO,ISS)
positive regulation of smooth muscle cell proliferation  (ISO,ISS)
positive regulation of transcription by RNA polymerase II  (ISO)
protein-containing complex assembly  (ISO,ISS)
regulation of cell differentiation  (ISO,ISS)
regulation of DNA-templated transcription  (IEA)
regulation of epithelial cell proliferation  (ISO)
regulation of myelination  (ISO,ISS)
regulation of neurogenesis  (IBA,ISO,ISS)
regulation of neuron differentiation  (ISO)
regulation of transcription by RNA polymerase II  (IBA)
S-shaped body morphogenesis  (ISO)
smoothened signaling pathway  (ISO,ISS)
specification of loop of Henle identity  (ISO)
system development  (IEA)
telencephalon development  (ISO,ISS)

Cellular Component
nucleus  (IBA,IEA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Molecular characterization of a rat negative regulator with a basic helix-loop-helix structure predominantly expressed in the developing nervous system. Akazawa C, etal., J Biol Chem 1992 Oct 25;267(30):21879-85.
2. Delta-Notch--and then? Protein interactions and proposed modes of repression by Hes and Hey bHLH factors. Fischer A and Gessler M, Nucleic Acids Res. 2007;35(14):4583-96. Epub 2007 Jun 22.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Overexpression of the Notch target genes Hes in vivo induces lymphoid and myeloid alterations. Kawamata S, etal., Oncogene. 2002 May 30;21(24):3855-63.
5. A molecular insight of Hes5-dependent inhibition of myelin gene expression: old partners and new players. Liu A, etal., EMBO J. 2006 Oct 18;25(20):4833-42. Epub 2006 Sep 28.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. Roles of the basic helix-loop-helix genes Hes1 and Hes5 in expansion of neural stem cells of the developing brain. Ohtsuka T, etal., J Biol Chem. 2001 Aug 10;276(32):30467-74. Epub 2001 Jun 8.
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. GOA pipeline RGD automated data pipeline
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Triggering of a Dll4-Notch1 loop impairs wound healing in diabetes. Zheng X, etal., Proc Natl Acad Sci U S A. 2019 Apr 2;116(14):6985-6994. doi: 10.1073/pnas.1900351116. Epub 2019 Mar 18.
Additional References at PubMed
PMID:10205173   PMID:10804175   PMID:10821751   PMID:11425898   PMID:12208538   PMID:12666205   PMID:15156153   PMID:15465493   PMID:15496443   PMID:15821257   PMID:15854743   PMID:16335396  
PMID:17093926   PMID:17331197   PMID:17849174   PMID:18048645   PMID:18579678   PMID:19050759   PMID:19124651   PMID:19682396   PMID:19855400   PMID:20431123   PMID:21259317   PMID:21300049  
PMID:22334042   PMID:25535395   PMID:30811836  


Genomics

Comparative Map Data
Hes5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85170,804,511 - 170,807,988 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5170,803,940 - 170,806,021 (+)EnsemblGRCr8
mRatBN7.25165,522,138 - 165,523,684 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5165,522,234 - 165,523,001 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5168,227,682 - 168,228,449 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05170,049,096 - 170,049,863 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05170,011,628 - 170,012,395 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05172,364,421 - 172,365,188 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5172,364,421 - 172,365,188 (+)Ensemblrn6Rnor6.0
Rnor_5.05175,820,392 - 175,821,159 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45171,763,869 - 171,764,636 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5163,728,713 - 163,729,480 (+)NCBICelera
RGSC_v3.15171,774,363 - 171,775,131 (+)NCBI
Cytogenetic Map5q36NCBI
HES5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812,528,745 - 2,530,263 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12,528,745 - 2,530,263 (-)Ensemblhg38GRCh38
GRCh3712,460,184 - 2,461,702 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3612,450,044 - 2,451,544 (-)NCBIBuild 36Build 36hg18NCBI36
Build 3412,492,347 - 2,493,846NCBI
Celera1124,288 - 125,788 (+)NCBICelera
Cytogenetic Map1p36.32NCBI
HuRef11,739,123 - 1,740,623 (-)NCBIHuRef
CHM1_112,446,941 - 2,448,441 (-)NCBICHM1_1
T2T-CHM13v2.011,970,389 - 1,971,907 (-)NCBIT2T-CHM13v2.0
Hes5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394155,042,358 - 155,046,829 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4155,045,380 - 155,046,828 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm384154,960,626 - 154,962,372 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4154,960,923 - 154,962,371 (+)Ensemblmm10GRCm38
MGSCv374154,335,032 - 154,336,480 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv364153,804,723 - 153,806,171 (+)NCBIMGSCv36mm8
Celera4157,232,968 - 157,234,416 (+)NCBICelera
Cytogenetic Map4E2NCBI
cM Map486.01NCBI
Hes5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554868,700,162 - 8,701,748 (+)Ensembl
ChiLan1.0NW_0049554868,700,212 - 8,701,581 (+)NCBIChiLan1.0ChiLan1.0
HES5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21225,717,334 - 225,719,200 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11224,377,907 - 224,379,810 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011,261,260 - 1,263,128 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
HES5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1557,387,961 - 57,389,412 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl557,388,674 - 57,389,388 (-)EnsemblcanFam3CanFam3.1
ROS_Cfam_1.0557,592,177 - 57,593,619 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl557,592,171 - 57,593,605 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1557,583,534 - 57,584,976 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0557,475,854 - 57,477,292 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0557,865,566 - 57,867,005 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Hes5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505828,418,080 - 28,419,331 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367371,046,613 - 1,047,950 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049367371,045,496 - 1,047,865 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HES5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl664,408,956 - 64,410,881 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1664,409,110 - 64,410,541 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
HES5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120129,023,750 - 129,028,790 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20129,027,370 - 129,028,065 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605433,373,940 - 33,375,505 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hes5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248187,516,189 - 7,518,734 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248187,516,279 - 7,517,654 (+)NCBIHetGla 1.0HetGla 1.0hetGla2

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:65
Count of miRNA genes:59
Interacting mature miRNAs:63
Transcripts:ENSRNOT00000018769
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555124766172190305Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5130249266172190305Rat
1354583Despr3Despair related QTL34.980.0002locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)5132930505172190305Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5141212838172190305Rat
1300119Bp180Blood pressure QTL 1803.82arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5149642129171146538Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5131708216172190305Rat
1549904Neuinf1Neuroinflammation QTL 130nervous system integrity trait (VT:0010566)blood T lymphocyte count (CMO:0000110)5160111176171146538Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)599905133172190305Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5133789363172190305Rat
1331803Rf32Renal function QTL 322.798kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)5134369199172190305Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5136631198172190305Rat
1354631Swd2Spike wave discharge measurement QTL 23.640.0002brain electrophysiology trait (VT:0010557)brain total spike-and-wave discharge duration (CMO:0001740)5156396728172190305Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5133081618172190305Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5138002522170842766Rat
1581505Rf54Renal function QTL 54kidney physiology trait (VT:0002136)kidney 20-HETE level (CMO:0001854)5133270647172190305Rat
1298090Bp155Blood pressure QTL 1553.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)5156289283171137955Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5160071170172129029Rat
2317753Glom24Glomerulus QTL 243.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)5141764300172190305Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5133081618172190305Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5133789363172190305Rat
1331721Bp210Blood pressure QTL 2103.413arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5148093485172129029Rat
1581510Cm54Cardiac mass QTL 543.40.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)5125969677172190305Rat

Markers in Region
UniSTS:259615  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr85170,804,636 - 170,805,166 (+)Marker Load Pipeline
mRatBN7.25165,522,293 - 165,522,823 (+)MAPPERmRatBN7.2
Rnor_6.05172,364,481 - 172,365,010NCBIRnor6.0
Rnor_5.05175,820,452 - 175,820,981UniSTSRnor5.0
RGSC_v3.45171,763,929 - 171,764,458UniSTSRGSC3.4
Celera5163,728,773 - 163,729,302UniSTS
Cytogenetic Map5q36UniSTS
UniSTS:265716  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25165,523,227 - 165,523,496 (+)MAPPERmRatBN7.2
Rnor_6.05172,365,415 - 172,365,683NCBIRnor6.0
Rnor_5.05175,821,386 - 175,821,654UniSTSRnor5.0
RGSC_v3.45171,764,863 - 171,765,131UniSTSRGSC3.4
Celera5163,729,707 - 163,729,975UniSTS
Cytogenetic Map5q36UniSTS
UniSTS:484887  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25165,522,260 - 165,523,215 (+)MAPPERmRatBN7.2
Rnor_6.05172,364,448 - 172,365,402NCBIRnor6.0
Rnor_5.05175,820,419 - 175,821,373UniSTSRnor5.0
RGSC_v3.45171,763,896 - 171,764,850UniSTSRGSC3.4
Celera5163,728,740 - 163,729,694UniSTS
Cytogenetic Map5q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 10 22 139 35 41 15 90 15 4 205 130 11 124 37 51 26 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000018769   ⟹   ENSRNOP00000018769
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5170,804,561 - 170,806,021 (+)Ensembl
mRatBN7.2 Ensembl5165,522,234 - 165,523,001 (+)Ensembl
Rnor_6.0 Ensembl5172,364,421 - 172,365,188 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000137815   ⟹   ENSRNOP00000105023
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5170,803,940 - 170,806,021 (+)Ensembl
RefSeq Acc Id: NM_024383   ⟹   NP_077359
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85170,804,577 - 170,805,344 (+)NCBI
mRatBN7.25165,522,234 - 165,523,001 (+)NCBI
Rnor_6.05172,364,421 - 172,365,188 (+)NCBI
Rnor_5.05175,820,392 - 175,821,159 (+)NCBI
RGSC_v3.45171,763,869 - 171,764,636 (+)RGD
Celera5163,728,713 - 163,729,480 (+)RGD
Sequence:
RefSeq Acc Id: XM_039110831   ⟹   XP_038966759
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85170,804,511 - 170,807,988 (+)NCBI
mRatBN7.25165,522,138 - 165,523,684 (+)NCBI
Protein Sequences
Protein RefSeqs NP_077359 (Get FASTA)   NCBI Sequence Viewer  
  XP_038966759 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAA02081 (Get FASTA)   NCBI Sequence Viewer  
  EDL81280 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000018769
  ENSRNOP00000018769.1
GenBank Protein Q03062 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_077359   ⟸   NM_024383
- UniProtKB: Q03062 (UniProtKB/Swiss-Prot),   A6IUM9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000018769   ⟸   ENSRNOT00000018769
RefSeq Acc Id: XP_038966759   ⟸   XM_039110831
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000105023   ⟸   ENSRNOT00000137815
Protein Domains
bHLH   Orange

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q03062-F1-model_v2 AlphaFold Q03062 1-166 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621340 AgrOrtholog
BioCyc Gene G2FUF-38943 BioCyc
Ensembl Genes ENSRNOG00000013850 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000018769 ENTREZGENE
  ENSRNOT00000018769.3 UniProtKB/Swiss-Prot
Gene3D-CATH 4.10.280.10 UniProtKB/Swiss-Prot
InterPro bHLH_dom UniProtKB/Swiss-Prot
  HES_HEY UniProtKB/Swiss-Prot
  HLH_DNA-bd_sf UniProtKB/Swiss-Prot
  Orange_dom UniProtKB/Swiss-Prot
KEGG Report rno:79225 UniProtKB/Swiss-Prot
NCBI Gene 79225 ENTREZGENE
PANTHER BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED UniProtKB/Swiss-Prot
Pfam Hairy_orange UniProtKB/Swiss-Prot
  HLH UniProtKB/Swiss-Prot
PhenoGen Hes5 PhenoGen
PROSITE BHLH UniProtKB/Swiss-Prot
  ORANGE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000013850 RatGTEx
SMART HLH UniProtKB/Swiss-Prot
  ORANGE UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47459 UniProtKB/Swiss-Prot
UniProt A6IUM9 ENTREZGENE, UniProtKB/TrEMBL
  HES5_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-11-11 Hes5  hes family bHLH transcription factor 5  Hes5  hairy and enhancer of split 5 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Hes5  hairy and enhancer of split 5 (Drosophila)      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Hes5  hairy and enhancer of split 5 (Drosophila)      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed only nervous system 728403