Hes5 (hes family bHLH transcription factor 5) - Rat Genome Database

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Gene: Hes5 (hes family bHLH transcription factor 5) Rattus norvegicus
Analyze
Symbol: Hes5
Name: hes family bHLH transcription factor 5
RGD ID: 621340
Description: Enables chromatin binding activity and double-stranded DNA binding activity. Involved in several processes, including generation of neurons; negative regulation of cell differentiation; and neuronal stem cell population maintenance. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to human HES5 (hes family bHLH transcription factor 5); PARTICIPATES IN Notch signaling pathway; Notch signaling pathway; INTERACTS WITH 2,2',4,4',5,5'-hexachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: hairy and enhancer of split 5; hairy and enhancer of split 5 (Drosophila); transcription factor HES-5
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25165,522,138 - 165,523,684 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl5165,522,234 - 165,523,001 (+)Ensembl
Rnor_6.05172,364,421 - 172,365,188 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5172,364,421 - 172,365,188 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05175,820,392 - 175,821,159 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45171,763,869 - 171,764,636 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15171,774,363 - 171,775,131 (+)NCBI
Celera5163,728,713 - 163,729,480 (+)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-amphetamine  (ISO)
1,2-dimethylhydrazine  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acetaldehyde  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
antimycin A  (ISO)
Aroclor 1254  (EXP)
arotinoid acid  (ISO)
arsenous acid  (ISO)
avobenzone  (ISO)
azoxystrobin  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (EXP,ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
carbamazepine  (ISO)
CHIR 99021  (ISO)
clofibrate  (ISO)
cortisol  (ISO)
crocidolite asbestos  (ISO)
Cyclopamine  (EXP)
cytarabine  (ISO)
diarsenic trioxide  (ISO)
dorsomorphin  (ISO)
entinostat  (ISO)
flavonoids  (EXP)
fluoxetine  (EXP)
folic acid  (EXP)
glycidol  (EXP)
ketamine  (EXP)
L-ascorbic acid  (ISO)
L-ascorbic acid 2-phosphate  (ISO)
mercury dibromide  (ISO)
methamphetamine  (EXP)
methylmercury chloride  (ISO)
ochratoxin A  (EXP)
p-chloromercuribenzoic acid  (ISO)
panobinostat  (ISO)
paracetamol  (ISO)
phenylmercury acetate  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (EXP)
poly(ethylene)  (ISO)
progesterone  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
SCH 23390  (EXP)
silicon dioxide  (ISO)
simvastatin  (EXP)
sodium arsenite  (ISO)
Soman  (EXP)
tebufenpyrad  (ISO)
thifluzamide  (ISO)
thyroxine  (EXP)
toluene  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)
XAV939  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
anterior/posterior pattern specification  (IBA)
astrocyte differentiation  (ISO,ISS)
BMP signaling pathway  (IEA,ISO)
brain development  (ISO,ISS)
camera-type eye development  (ISO,ISS)
cartilage development  (ISO,ISS)
cell adhesion  (ISO,ISS)
cell maturation  (ISO,ISS)
central nervous system myelination  (ISO,ISS)
chondrocyte differentiation  (ISO,ISS)
comma-shaped body morphogenesis  (ISO)
establishment of epithelial cell polarity  (ISO)
forebrain radial glial cell differentiation  (IDA)
glial cell fate commitment  (ISO,ISS)
inner ear auditory receptor cell differentiation  (IEA,ISO)
inner ear receptor cell stereocilium organization  (ISO)
metanephric nephron tubule morphogenesis  (ISO)
negative regulation of astrocyte differentiation  (ISO,ISS)
negative regulation of forebrain neuron differentiation  (IDA)
negative regulation of inner ear auditory receptor cell differentiation  (ISO)
negative regulation of inner ear receptor cell differentiation  (ISO)
negative regulation of neuron differentiation  (ISO,ISS)
negative regulation of oligodendrocyte differentiation  (ISO,ISS)
negative regulation of pro-B cell differentiation  (IMP)
negative regulation of stem cell differentiation  (ISO,ISS)
negative regulation of transcription by RNA polymerase II  (IDA,ISO)
negative regulation of transcription, DNA-templated  (IDA,ISO)
neural tube development  (ISO,ISS)
neuron differentiation  (IEP,ISO)
neuronal stem cell population maintenance  (IDA,ISO)
Notch signaling pathway  (ISO,ISS)
oligodendrocyte development  (ISO,ISS)
oligodendrocyte differentiation  (ISO)
positive regulation of BMP signaling pathway  (ISO,ISS)
positive regulation of cell population proliferation  (ISO,ISS)
positive regulation of Notch signaling pathway  (ISO)
positive regulation of receptor signaling pathway via JAK-STAT  (ISO,ISS)
positive regulation of smooth muscle cell proliferation  (ISO,ISS)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of transcription, DNA-templated  (ISO,ISS)
positive regulation of tyrosine phosphorylation of STAT protein  (ISO,ISS)
protein-containing complex assembly  (ISO,ISS)
regulation of cell differentiation  (ISO,ISS)
regulation of epithelial cell proliferation  (ISO)
regulation of myelination  (ISO,ISS)
regulation of neurogenesis  (IBA,ISO,ISS)
regulation of neuron differentiation  (ISO)
regulation of transcription by RNA polymerase II  (IBA)
S-shaped body morphogenesis  (ISO)
smoothened signaling pathway  (ISO,ISS)
specification of loop of Henle identity  (ISO)
telencephalon development  (ISO,ISS)

Cellular Component
nucleus  (IEA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:10205173   PMID:10804175   PMID:10821751   PMID:11425898   PMID:12208538   PMID:12666205   PMID:15156153   PMID:15465493   PMID:15496443   PMID:15821257   PMID:15854743   PMID:16335396  
PMID:17093926   PMID:17331197   PMID:17849174   PMID:18048645   PMID:18579678   PMID:19050759   PMID:19124651   PMID:19682396   PMID:19855400   PMID:20431123   PMID:21259317   PMID:21300049  
PMID:22334042   PMID:25535395   PMID:30811836  


Genomics

Comparative Map Data
Hes5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25165,522,138 - 165,523,684 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl5165,522,234 - 165,523,001 (+)Ensembl
Rnor_6.05172,364,421 - 172,365,188 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5172,364,421 - 172,365,188 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05175,820,392 - 175,821,159 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45171,763,869 - 171,764,636 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15171,774,363 - 171,775,131 (+)NCBI
Celera5163,728,713 - 163,729,480 (+)NCBICelera
Cytogenetic Map5q36NCBI
HES5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812,528,745 - 2,530,263 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl12,528,745 - 2,530,263 (-)EnsemblGRCh38hg38GRCh38
GRCh3712,460,184 - 2,461,702 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3612,450,044 - 2,451,544 (-)NCBINCBI36hg18NCBI36
Build 3412,492,347 - 2,493,846NCBI
Celera1124,288 - 125,788 (+)NCBI
Cytogenetic Map1p36.32NCBI
HuRef11,739,123 - 1,740,623 (-)NCBIHuRef
CHM1_112,446,941 - 2,448,441 (-)NCBICHM1_1
Hes5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394155,042,358 - 155,046,829 (+)NCBIGRCm39mm39
GRCm39 Ensembl4155,045,380 - 155,046,828 (+)Ensembl
GRCm384154,960,626 - 154,962,372 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4154,960,923 - 154,962,371 (+)EnsemblGRCm38mm10GRCm38
MGSCv374154,335,032 - 154,336,480 (+)NCBIGRCm37mm9NCBIm37
MGSCv364153,804,723 - 153,806,171 (+)NCBImm8
Celera4157,232,968 - 157,234,416 (+)NCBICelera
Cytogenetic Map4E2NCBI
cM Map486.01NCBI
Hes5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554868,700,162 - 8,701,748 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554868,700,212 - 8,701,581 (+)NCBIChiLan1.0ChiLan1.0
HES5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Mhudiblu_PPA_v011,261,260 - 1,263,128 (-)NCBIMhudiblu_PPA_v0panPan3
HES5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1557,387,961 - 57,389,412 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl557,388,674 - 57,389,388 (-)EnsemblCanFam3.1canFam3CanFam3.1
ROS_Cfam_1.0557,592,177 - 57,593,619 (-)NCBI
ROS_Cfam_1.0 Ensembl557,592,171 - 57,593,605 (-)Ensembl
UMICH_Zoey_3.1557,583,534 - 57,584,976 (-)NCBI
UNSW_CanFamBas_1.0557,475,854 - 57,477,292 (-)NCBI
UU_Cfam_GSD_1.0557,865,566 - 57,867,005 (-)NCBI
Hes5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505828,418,080 - 28,419,331 (-)NCBI
SpeTri2.0NW_0049367371,045,496 - 1,047,865 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HES5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl664,409,115 - 64,411,006 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1664,409,110 - 64,410,541 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
HES5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120129,023,750 - 129,028,790 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl20129,027,370 - 129,028,065 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605433,373,940 - 33,375,505 (+)NCBIVero_WHO_p1.0
Hes5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248187,516,279 - 7,517,654 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
UniSTS:259615  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25165,522,293 - 165,522,823 (+)MAPPERmRatBN7.2
Rnor_6.05172,364,481 - 172,365,010NCBIRnor6.0
Rnor_5.05175,820,452 - 175,820,981UniSTSRnor5.0
RGSC_v3.45171,763,929 - 171,764,458UniSTSRGSC3.4
Celera5163,728,773 - 163,729,302UniSTS
Cytogenetic Map5q36UniSTS
UniSTS:265716  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25165,523,227 - 165,523,496 (+)MAPPERmRatBN7.2
Rnor_6.05172,365,415 - 172,365,683NCBIRnor6.0
Rnor_5.05175,821,386 - 175,821,654UniSTSRnor5.0
RGSC_v3.45171,764,863 - 171,765,131UniSTSRGSC3.4
Celera5163,729,707 - 163,729,975UniSTS
Cytogenetic Map5q36UniSTS
UniSTS:484887  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25165,522,260 - 165,523,215 (+)MAPPERmRatBN7.2
Rnor_6.05172,364,448 - 172,365,402NCBIRnor6.0
Rnor_5.05175,820,419 - 175,821,373UniSTSRnor5.0
RGSC_v3.45171,763,896 - 171,764,850UniSTSRGSC3.4
Celera5163,728,740 - 163,729,694UniSTS
Cytogenetic Map5q36UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5121846814166846814Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5124965598166875058Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5126424772166875058Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5127798274166875058Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5127798274166875058Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5128506074166875058Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5128506074166875058Rat
634349Bp139Blood pressure QTL 1390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5128924607166875058Rat
738018Anxrr4Anxiety related response QTL 45.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)5130130159166875058Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5131345754166875058Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5132717196165560427Rat
631562Apr2Acute phase response QTL 23.7blood murinoglobulin 1 amount (VT:0010597)plasma murinoglobulin 1 level (CMO:0001931)5135927956166875058Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5135929696166875058Rat
1331721Bp210Blood pressure QTL 2103.413arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5143069996166846814Rat
631272Lanf1Left ventricular atrial natriuretic factor QTL 112heart left ventricle natriuretic peptide A amount (VT:0010596)heart left ventricle natriuretic peptide A level (CMO:0002165)5151113452166875058Rat
1549904Neuinf1Neuroinflammation QTL 130nervous system integrity trait (VT:0010566)blood T lymphocyte count (CMO:0000110)5154828214166875058Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:65
Count of miRNA genes:59
Interacting mature miRNAs:63
Transcripts:ENSRNOT00000018769
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 9 67 3
Low 2 5 7 7 10 10 3
Below cutoff 1 6 13 5 3 5 7 9 4 17 6 7

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000018769   ⟹   ENSRNOP00000018769
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5165,522,234 - 165,523,001 (+)Ensembl
Rnor_6.0 Ensembl5172,364,421 - 172,365,188 (+)Ensembl
RefSeq Acc Id: NM_024383   ⟹   NP_077359
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25165,522,234 - 165,523,001 (+)NCBI
Rnor_6.05172,364,421 - 172,365,188 (+)NCBI
Rnor_5.05175,820,392 - 175,821,159 (+)NCBI
RGSC_v3.45171,763,869 - 171,764,636 (+)RGD
Celera5163,728,713 - 163,729,480 (+)RGD
Sequence:
RefSeq Acc Id: XM_039110831   ⟹   XP_038966759
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25165,522,138 - 165,523,684 (+)NCBI
Protein Sequences
Protein RefSeqs NP_077359 (Get FASTA)   NCBI Sequence Viewer  
  XP_038966759 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAA02081 (Get FASTA)   NCBI Sequence Viewer  
  EDL81280 (Get FASTA)   NCBI Sequence Viewer  
  Q03062 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_077359   ⟸   NM_024383
- UniProtKB: Q03062 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000018769   ⟸   ENSRNOT00000018769
RefSeq Acc Id: XP_038966759   ⟸   XM_039110831
- Peptide Label: isoform X1
Protein Domains
bHLH   Orange

Protein Structures
Name Modeller Protein Id AA Range Protein Structure Video
AF-Q03062-F1-model_v2 AlphaFold Q03062 1-166 view protein structure  

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (MRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621340 AgrOrtholog
BioCyc Gene G2FUF-38943 BioCyc
Ensembl Genes ENSRNOG00000013850 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000018769 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000018769 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 4.10.280.10 UniProtKB/Swiss-Prot
InterPro bHLH_dom UniProtKB/Swiss-Prot
  HLH_DNA-bd_sf UniProtKB/Swiss-Prot
  Orange_dom UniProtKB/Swiss-Prot
KEGG Report rno:79225 UniProtKB/Swiss-Prot
NCBI Gene 79225 ENTREZGENE
Pfam Hairy_orange UniProtKB/Swiss-Prot
  HLH UniProtKB/Swiss-Prot
PhenoGen Hes5 PhenoGen
PROSITE BHLH UniProtKB/Swiss-Prot
  ORANGE UniProtKB/Swiss-Prot
SMART HLH UniProtKB/Swiss-Prot
  ORANGE UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47459 UniProtKB/Swiss-Prot
UniProt HES5_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-11-11 Hes5  hes family bHLH transcription factor 5  Hes5  hairy and enhancer of split 5 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Hes5  hairy and enhancer of split 5 (Drosophila)      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Hes5  hairy and enhancer of split 5 (Drosophila)      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed only nervous system 728403