Slc2a5 (solute carrier family 2 member 5)

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Gene: Slc2a5 (solute carrier family 2 member 5) Rattus norvegicus

Analyze

Symbol:

Slc2a5

Name:

solute carrier family 2 member 5

RGD ID:

68328

Description:

Exhibits fructose binding activity; fructose transmembrane transporter activity; and glucose transmembrane transporter activity. Involved in cellular response to fructose stimulus; fructose import across plasma membrane; and glucose transmembrane transport. Localizes to integral component of plasma membrane and sarcolemma. Orthologous to human SLC2A5 (solute carrier family 2 member 5); INTERACTS WITH 2,3,4,7,8-Pentachlorodibenzofuran; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Also known as:

fructose transporter; glucose transporter type 5, small intestine; GLUT-5; solute carrier family 2 (facilitated glucose transporter) member 5; solute carrier family 2 (facilitated glucose transporter), member 5; solute carrier family 2 (facilitated glucose/fructose transporter), member 5; solute carrier family 2, facilitated glucose transporter member 5; solute carrier family 2, member 5

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	SLC2A5 (solute carrier family 2 member 5)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Slc2a5 (solute carrier family 2 (facilitated glucose transporter), member 5)	HGNC	Treefam, EggNOG, OrthoMCL, NCBI, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):	Slc2a5 (solute carrier family 2 member 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	SLC2A5 (solute carrier family 2 member 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	LOC489640 (solute carrier family 2, facilitated glucose transporter member 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Slc2a5 (solute carrier family 2 member 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	SLC2A5 (solute carrier family 2 member 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):	SLC2A5 (solute carrier family 2 member 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Slc2a5 (solute carrier family 2 member 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	SLC2A7 (solute carrier family 2 member 7)	HGNC	OrthoDB
Alliance orthologs ³
Homo sapiens (human):	SLC2A5 (solute carrier family 2 member 5)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|TreeFam)
Mus musculus (house mouse):	Slc2a5 (solute carrier family 2 (facilitated glucose transporter), member 5)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|TreeFam)
Drosophila melanogaster (fruit fly):	CG7882	Alliance	DIOPT (Ensembl Compara\|InParanoid\|TreeFam)
Drosophila melanogaster (fruit fly):	sut1	Alliance	DIOPT (Ensembl Compara\|InParanoid\|TreeFam)
Drosophila melanogaster (fruit fly):	sut2	Alliance	DIOPT (Ensembl Compara\|InParanoid\|TreeFam)
Saccharomyces cerevisiae (baker's yeast):	VPS73	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER)
Saccharomyces cerevisiae (baker's yeast):	YBR241C	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER)
Caenorhabditis elegans (roundworm):	C35A11.4	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Drosophila melanogaster (fruit fly):	sut3	Alliance	DIOPT (Ensembl Compara\|InParanoid\|TreeFam)
Caenorhabditis elegans (roundworm):	K08F9.1	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Caenorhabditis elegans (roundworm):	Y37A1A.3	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Caenorhabditis elegans (roundworm):	slcf-2	Alliance	DIOPT (Ensembl Compara\|PANTHER)

Latest Assembly:

Rnor_6.0 - RGSC Genome Assembly v6.0

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	5	160,583,055 - 160,609,994 (+)	NCBI
Rnor_6.0 Ensembl	5	167,141,875 - 167,174,310 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	5	167,142,182 - 167,174,203 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	5	170,782,871 - 170,808,467 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	167,240,442 - 167,285,761 (+)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	5	167,250,629 - 167,295,948 (+)	NCBI
Celera	5	158,844,838 - 158,869,525 (+)	NCBI		Celera
Cytogenetic Map	5	q36	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Breast Neoplasms (ISO)

long QT syndrome (ISO)

Neurodevelopmental Disorders (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-demecolcine (ISO)

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (ISO)

2,3,4,7,8-Pentachlorodibenzofuran (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

3',5'-cyclic AMP (EXP,ISO)

3,3',4,4',5-pentachlorobiphenyl (EXP)

3,3',5-triiodo-L-thyronine (EXP)

3-chloropropane-1,2-diol (EXP)

3-isobutyl-1-methyl-7H-xanthine (ISO)

3H-1,2-dithiole-3-thione (EXP)

4,4'-sulfonyldiphenol (ISO)

acetamide (EXP)

acrylamide (ISO)

actinomycin D (EXP)

aflatoxin B1 (ISO)

aldehydo-D-glucose (EXP,ISO)

all-trans-retinoic acid (ISO)

ammonium chloride (EXP)

antirheumatic drug (ISO)

arsane (ISO)

arsenic atom (ISO)

arsenous acid (ISO)

benzo[a]pyrene (ISO)

beta-naphthoflavone (ISO)

bisphenol A (EXP,ISO)

bucladesine (ISO)

C60 fullerene (EXP)

cadmium atom (ISO)

cadmium dichloride (EXP)

calcitriol (ISO)

carbon nanotube (ISO)

chromium(6+) (ISO)

cisplatin (ISO)

clofibrate (EXP,ISO)

colforsin daropate hydrochloride (EXP,ISO)

curcumin (ISO)

cycloheximide (EXP)

cyclosporin A (EXP)

D-glucose (EXP,ISO)

dexamethasone (EXP,ISO)

diarsenic trioxide (ISO)

diethyl maleate (EXP)

ethyl methanesulfonate (ISO)

formaldehyde (ISO)

fructose (EXP,ISO)

furan (ISO)

glucose (EXP,ISO)

GW 4064 (ISO)

hydroquinone (ISO)

Indeno[1,2,3-cd]pyrene (ISO)

indometacin (ISO)

iron atom (EXP,ISO)

iron(0) (EXP,ISO)

ketamine (EXP)

lead diacetate (EXP)

levonorgestrel (ISO)

LY294002 (EXP)

metformin (EXP)

methamphetamine (ISO)

mifepristone (EXP)

mirtazapine (ISO)

N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide (ISO)

N-nitrosodiethylamine (EXP)

nickel atom (ISO)

ochratoxin A (EXP)

ozone (ISO)

paracetamol (ISO)

perfluorooctane-1-sulfonic acid (ISO)

phenformin (EXP)

phenobarbital (EXP,ISO)

pioglitazone (ISO)

pirinixic acid (EXP,ISO)

propiconazole (EXP)

rotenone (EXP)

silicon dioxide (ISO)

sodium dichromate (EXP)

sodium fluoride (ISO)

Soman (EXP)

sucrose (EXP)

sulforaphane (ISO)

tamibarotene (ISO)

tamoxifen (EXP)

testosterone (EXP)

testosterone undecanoate (ISO)

tetrachloromethane (EXP,ISO)

tetracycline (EXP)

thioacetamide (EXP)

titanium dioxide (ISO)

toluene (EXP)

triadimefon (EXP)

tributylstannane (ISO)

trichostatin A (ISO)

triphenyl phosphate (EXP)

triptonide (ISO)

tris(2-butoxyethyl) phosphate (ISO)

troglitazone (EXP)

valdecoxib (EXP)

valproic acid (EXP,ISO)

vancomycin (ISO)

wortmannin (EXP)

zinc atom (EXP,ISO)

zinc(0) (EXP,ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to fructose stimulus (IDA,ISO,ISS)

fructose import across plasma membrane (IDA,IEA,ISO)

fructose transmembrane transport (IBA,IDA,IEP,ISO)

glucose transmembrane transport (IDA)

regulation of systemic arterial blood pressure mediated by a chemical signal (ISO,ISS)

response to fructose (ISO)

Cellular Component

apical plasma membrane (IEA,ISO,ISS)

integral component of plasma membrane (IDA,IEA,ISO)

membrane (IDA)

plasma membrane (ISO)

sarcolemma (IDA,IEA)

Molecular Function

fructose binding (IDA)

fructose transmembrane transporter activity (IBA,IDA,IEA,ISO)

glucose transmembrane transporter activity (IDA)

protein binding (ISO)

References

References - curated


1.	Darakhshan F, etal., Biochem J. 1998 Dec 1;336 ( Pt 2):361-6.
2.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	GOA data from the GO Consortium
4.	Inukai K, etal., Endocrinology 1993 Nov;133(5):2009-14.
5.	Jiang L, etal., Am J Physiol Gastrointest Liver Physiol 2001 Sep;281(3):G666-74.
6.	MGD data from the GO Consortium
7.	NCBI rat LocusLink and RefSeq merged data July 26, 2002
8.	Nomura N, etal., Nature. 2015 Oct 15;526(7573):397-401. doi: 10.1038/nature14909. Epub 2015 Sep 30.
9.	Rand EB, etal., Am J Physiol 1993 Jun;264(6 Pt 1):G1169-76.
10.	RGD automated data pipeline
11.	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12.	RGD automated import pipeline for gene-chemical interactions
13.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
14.	Tentative Sequence Data IDs. TIGR Gene Index, Rat Data

Additional References at PubMed

PMID:12914929	PMID:15489334	PMID:16581195	PMID:16627065	PMID:17485832	PMID:17947353	PMID:18154936	PMID:18496516	PMID:18556366	PMID:19056867	PMID:19091748	PMID:19956534
PMID:21222652	PMID:23376485	PMID:23533145	PMID:26071406	PMID:28083649

Genomics

Comparative Map Data

Slc2a5
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	5	160,583,055 - 160,609,994 (+)	NCBI
Rnor_6.0 Ensembl	5	167,141,875 - 167,174,310 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	5	167,142,182 - 167,174,203 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	5	170,782,871 - 170,808,467 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	167,240,442 - 167,285,761 (+)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	5	167,250,629 - 167,295,948 (+)	NCBI
Celera	5	158,844,838 - 158,869,525 (+)	NCBI		Celera
Cytogenetic Map	5	q36	NCBI

SLC2A5
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	1	9,035,106 - 9,088,478 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	1	9,035,106 - 9,072,259 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	1	9,095,165 - 9,132,318 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	9,019,594 - 9,052,257 (-)	NCBI	NCBI36		hg18	NCBI36
Build 34	1	9,031,272 - 9,063,936	NCBI
Celera	1	8,205,681 - 8,257,881 (-)	NCBI
Cytogenetic Map	1	p36.23	NCBI
HuRef	1	8,246,781 - 8,279,898 (-)	NCBI		HuRef
CHM1_1	1	9,086,735 - 9,120,070 (-)	NCBI		CHM1_1

Slc2a5
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	150,203,801 - 150,228,625 (+)	NCBI	GRCm39		mm39
GRCm39 Ensembl	4	150,203,740 - 150,228,626 (+)	Ensembl
GRCm38	4	150,119,344 - 150,144,168 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	150,119,283 - 150,144,169 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	4	149,493,453 - 149,518,277 (+)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	4	148,963,144 - 148,987,968 (+)	NCBI			mm8
Celera	4	152,395,331 - 152,418,947 (+)	NCBI		Celera
Cytogenetic Map	4	E2	NCBI

Slc2a5
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955486	4,194,833 - 4,211,377 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955486	4,194,568 - 4,208,568 (+)	NCBI	ChiLan1.0	ChiLan1.0

SLC2A5
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	1	9,028,790 - 9,078,509 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	9,028,790 - 9,078,509 (-)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	1	7,792,361 - 7,840,634 (-)	NCBI	Mhudiblu_PPA_v0		panPan3

LOC489640
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	5	62,417,234 - 62,444,903 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	5	62,417,591 - 62,442,922 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	5	62,434,685 - 62,454,581 (-)	NCBI
ROS_Cfam_1.0	5	62,644,215 - 62,664,060 (-)	NCBI
UMICH_Zoey_3.1	5	62,642,371 - 62,662,203 (-)	NCBI
UNSW_CanFamBas_1.0	5	62,506,640 - 62,526,482 (-)	NCBI
UU_Cfam_GSD_1.0	5	62,910,582 - 62,930,423 (-)	NCBI

Slc2a5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	32,741,273 - 32,767,573 (-)	NCBI
SpeTri2.0	NW_004936623	3,226,533 - 3,249,909 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SLC2A5
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	69,507,825 - 69,535,372 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	69,507,829 - 69,535,794 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

SLC2A5
(Chlorocebus sabaeus - African green monkey)

Vervet Assembly	Chr	Position (strand)	Source	Genome Browsers
Vervet Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	122,669,220 - 122,714,708 (+)	NCBI
ChlSab1.1 Ensembl	20	122,683,373 - 122,716,540 (+)	Ensembl
Vero_WHO_p1.0	NW_023666054	26,700,362 - 26,733,757 (+)	NCBI

Slc2a5
(Heterocephalus glaber - naked mole-rat)

Molerat Assembly	Chr	Position (strand)	Source	Genome Browsers
Molerat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624818	3,132,345 - 3,156,184 (+)	NCBI

Position Markers

BE119358

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	5	167,168,284 - 167,168,462	NCBI	Rnor6.0
RGSC_v3.4	5	167,279,774 - 167,279,951	UniSTS	RGSC3.4
Celera	5	158,863,573 - 158,863,750	UniSTS
RH 3.4 Map	5	1115.2	UniSTS
Cytogenetic Map	5	q36	UniSTS

QTLs in Region (Rnor_6.0)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2302369	Scl60	Serum cholesterol level QTL 60	3.13		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	5	149568588	167739697	Rat
61444	Strs2	Sensitivity to stroke QTL 2	4.7		cerebrum integrity trait (VT:0010549)	post-insult time to onset of cerebrovascular lesion (CMO:0002343)	5	142309061	173707219	Rat
724525	Bp147	Blood pressure QTL 147	4.3	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	132551937	173707219	Rat
1331721	Bp210	Blood pressure QTL 210	3.413		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	5	149029982	173687766	Rat
1298090	Bp155	Blood pressure QTL 155	3.8		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	5	157212422	167739539	Rat
631562	Apr2	Acute phase response QTL 2	3.7		blood murinoglobulin 1 amount (VT:0010597)	plasma murinoglobulin 1 level (CMO:0001931)	5	142307322	173707219	Rat
738018	Anxrr4	Anxiety related response QTL 4	5.1		exploratory behavior trait (VT:0010471)	percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)	5	136354114	173707219	Rat
631272	Lanf1	Left ventricular atrial natriuretic factor QTL 1	12		heart left ventricle natriuretic peptide A amount (VT:0010596)	heart left ventricle natriuretic peptide A level (CMO:0002165)	5	157319671	173707219	Rat
631505	Bp103	Blood pressure QTL 103	3.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	138154677	172402610	Rat
1302790	Scl20	Serum cholesterol level QTL 20	6.4	0.0001	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	84963058	173504662	Rat
1641920	Colcs1	Colorectal carcinoma susceptibility QTL 1	2.99	0.0055	intestine integrity trait (VT:0010554)	benign colorectal tumor surface area measurement (CMO:0001799)	5	128687766	173687766	Rat
1598819	Bp292	Blood pressure QTL 292	4.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	133943857	173707219	Rat
1598861	Cm64	Cardiac mass QTL 64	2.9		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	5	133943857	173707219	Rat
634349	Bp139	Blood pressure QTL 139		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	134197905	173707219	Rat
1578766	Tcas11	Tongue tumor susceptibility QTL 11	4.12		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	5	47745646	167946134	Rat
1354631	Swd2	Spike wave discharge measurement QTL 2	3.64	0.0002	brain electrophysiology trait (VT:0010557)	brain total spike-and-wave discharge duration (CMO:0001740)	5	157319671	171194163	Rat
1549904	Neuinf1	Neuroinflammation QTL 1	3	0	nervous system integrity trait (VT:0010566)	blood T lymphocyte count (CMO:0000110)	5	161084664	173707219	Rat
2313096	Bmd78	Bone mineral density QTL 78	3.1	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	5	150360936	167946134	Rat
61393	Bp7	Blood pressure QTL 7	4.5	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	61612600	168109659	Rat
7794791	Mcs33	Mammary carcinoma susceptibility QTL 33	1.93		mammary gland integrity trait (VT:0010552)	mammary tumor incidence/prevalence measurement (CMO:0000946)	5	136640731	173707219	Rat
8552908	Pigfal4	Plasma insulin-like growth factor 1 level QTL 4	6.6		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	5	134712342	173707219	Rat
8694169	Bw148	Body weight QTL 148	5	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	5	134712342	173707219	Rat
10053720	Scort26	Serum corticosterone level QTL 26	2.06	0.0147	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	5	131077716	173707219	Rat

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	472
Count of miRNA genes:	248
Interacting mature miRNAs:	292
Transcripts:	ENSRNOT00000024054
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	1		10	9		9				17	9
Low	2	4	45	30	19	30	8	9	58	16	32	11	8
Below cutoff		35	2	2		2		2	16	2

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_031741	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039110731	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC076378	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC161843	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473968	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	D13871	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	D28562	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000162	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	L05195	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000024054 ⟹ ENSRNOP00000024054

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	5	167,142,182 - 167,174,203 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000089314 ⟹ ENSRNOP00000068562

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	5	167,141,875 - 167,174,310 (+)	Ensembl

RefSeq Acc Id:

NM_031741 ⟹ NP_113929

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	5	160,583,238 - 160,609,994 (+)	NCBI
Rnor_6.0	5	167,142,182 - 167,174,203 (+)	NCBI
Rnor_5.0	5	170,782,871 - 170,808,467 (+)	NCBI
RGSC_v3.4	5	167,240,442 - 167,285,761 (+)	RGD
Celera	5	158,844,838 - 158,869,525 (+)	NCBI

Sequence:

show sequence

TGAGGAGGTGAGCCAGCTGCAGGCTACCCTTGCAGAGCAACGATGGAGAAAGAGGATCAAGAGA
AGACAGGGAAGCTGACCCTGGTCCTTGCCCTGGCAACTTTCCTAGCTGCCTTTGGCTCCTCCTT
CCAGTATGGGTACAACGTGGCTGCTGTCAACTCGCCCTCAGAGTTCATGCAGCAGTTCTACAAT
GACACCTACTACGACAGAAACAAGGAGAACATTGAGTCCTTCACCCTGACGCTGCTGTGGTCCC
TGACTGTCTCCATGTTCCCCTTTGGAGGTTTTATAGGATCTCTCATGGTTGGATTCTTGGTGAA
TAACTTGGGCAGAAAAGGGGCCTTACTGTTCAACAACATATTCTCCATCCTGCCGGCCATCTTG
ATGGGGTGCAGCAAAATTGCCAAATCCTTTGAGATAATAATTGCTTCCAGACTTCTGGTTGGAA
TATGTGCAGGTATATCTTCCAACGTGGTCCCCATGTACTTAGGGGAGCTAGCCCCCAAAAACCT
GCGAGGGGCTCTTGGAGTGGTTCCTCAGCTCTTCATCACTGTGGGCATCCTTGTGGCCCAGCTG
TTTGGCCTTCGGAGTGTCTTGGCAAGCGAGGAAGGCTGGCCAATCCTCCTGGGTCTGACTGGAG
TCCCTGCCGGCCTGCAGCTCCTCTTGCTGCCCTTCTTTCCTGAGAGCCCCCGCTACCTGCTGAT
TCAGAAGAAAAATGAATCAGCTGCTGAGAAAGCCCTTCAGACCCTTCGAGGTTGGAAAGATGTG
GACATGGAGATGGAGGAAATCCGGAAGGAGGATGAGGCTGAGAAGGCGGCAGGCTTCATCTCTG
TGTGGAAGCTGTTCCGCATGCAGTCCCTCCGCTGGCAACTCATCTCCACGATCGTCCTCATGAC
CGGCCAGCAGCTGTCAGGAGTGAACGCGATTTACTACTACGCTGACCAGATCTACCTCAGCGCA
GGGGTGAAAAGCAACGACGTCCAATATGTGACGGCTGGGACTGGGGCCGTCAACGTGTTCATGA
CCATGGTCACGGTTTTTGTGGTAGAGCTTTGGGGACGTCGGAATCTTCTCCTCATCGGCTTCTC
CACCTGCCTCACAGCTTGCATAGTGCTGACGGTCGCACTGGCACTGCAGAACACCATCTCCTGG
ATGCCCTATGTCAGCATCGTCTGTGTCATTGTCTACGTCATAGGACACGCCGTGGGGCCCAGTC
CCATCCCTGCCCTGTTCATCACCGAGATCTTCCTGCAATCCTCTCGACCATCCGCCTACATGAT
CGGAGGCAGCGTCCACTGGCTCTCTAACTTCATCGTGGGCCTCATCTTCCCGTTCATTCAAGTG
GGCCTTGGTCCTTACAGCTTCATCATCTTTGCGATTATATGTCTCCTCACCTCCATCTACATCT
TCATGGTCGTCCCAGAGACCAAGGGCAGGACGTTTGTCGAGATCAACCAGATTTTTGCCAAGAA
GAACAAGGTATCGGACGTATATCCGGAGAAGGAGGAAAAGGAGCTTAATGACCTCCCACCTGCT
ACCCGGGAGCAGTAGCAGAGCCAGGCCACCAGGCAGTATGGCCAGTCTGCATGGGCCTCCTGTC
TAGACTTTGGTTCTGGGTTCTTAGTGTCTGTGACACTGGGAGGGACACGAGCCTGGCGGGGAAT
GGCAGCCCTCCACTCAGTGGGGACACCTGACGGGCTTTCGTGCTTCCGTGCTGTCCCTAACCAT
AGAGGCCAGTCACGGGCTCTTGGTCACACACAAAGCCATACCTGGCCTTTGCTGGGTTGACTGT
GGCGAGGGTCTTGTAACATTGCTTTTCTAACAAAAACAGTTGCCGAGAGACAAGACGTGACGGT
CCTATTTTTTTTTTAACTTTTTTTTTCTATTCTTTTTTTTTTTTTTTTTTCGGAGCTGGGGATT
GAACCCAGGGCCTTGCGCTTGCTAGGCAAGCGCTCTACCACTGAGCCAAATCCCTTGTGTGGCT
CCTCCCATGGGCGTGGAGAGACCACTGGCATCTGCTGGTGATTGATGTGGTCCTCTTTTTCTGA
CCCAGCCATGTCACAAAGCTGAGGAACAGGCCACTTGGGGAGACACACGGAGCGTGAATTATCA
ACTGTCAACGACAGTATTCTGTTTAGCCAATAAAACAGATCTGATCACTTCTTAAAA

hide sequence

RefSeq Acc Id:

XM_039110731 ⟹ XP_038966659

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	5	160,583,055 - 160,606,809 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_113929	(Get FASTA)	NCBI Sequence Viewer
	XP_038966659	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA02627	(Get FASTA)	NCBI Sequence Viewer
	AAH76378	(Get FASTA)	NCBI Sequence Viewer
	AAI61843	(Get FASTA)	NCBI Sequence Viewer
	BAA02983	(Get FASTA)	NCBI Sequence Viewer
	BAA05912	(Get FASTA)	NCBI Sequence Viewer
	EDL81179	(Get FASTA)	NCBI Sequence Viewer
	EDL81180	(Get FASTA)	NCBI Sequence Viewer
	P43427	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_113929 ⟸ NM_031741

- UniProtKB:

P43427 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MEKEDQEKTGKLTLVLALATFLAAFGSSFQYGYNVAAVNSPSEFMQQFYNDTYYDRNKENIESF
TLTLLWSLTVSMFPFGGFIGSLMVGFLVNNLGRKGALLFNNIFSILPAILMGCSKIAKSFEIII
ASRLLVGICAGISSNVVPMYLGELAPKNLRGALGVVPQLFITVGILVAQLFGLRSVLASEEGWP
ILLGLTGVPAGLQLLLLPFFPESPRYLLIQKKNESAAEKALQTLRGWKDVDMEMEEIRKEDEAE
KAAGFISVWKLFRMQSLRWQLISTIVLMTGQQLSGVNAIYYYADQIYLSAGVKSNDVQYVTAGT
GAVNVFMTMVTVFVVELWGRRNLLLIGFSTCLTACIVLTVALALQNTISWMPYVSIVCVIVYVI
GHAVGPSPIPALFITEIFLQSSRPSAYMIGGSVHWLSNFIVGLIFPFIQVGLGPYSFIIFAIIC
LLTSIYIFMVVPETKGRTFVEINQIFAKKNKVSDVYPEKEEKELNDLPPATREQ

hide sequence

RefSeq Acc Id:

ENSRNOP00000024054 ⟸ ENSRNOT00000024054

RefSeq Acc Id:

ENSRNOP00000068562 ⟸ ENSRNOT00000089314

RefSeq Acc Id:	XP_038966659 ⟸ XM_039110731
- Peptide Label:	isoform X1

Protein Domains

MFS

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13694279

Promoter ID:

EPDNEW_R4804

Type:

single initiation site

Name:

Slc2a5_1

Description:

solute carrier family 2 member 5

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	5	167,142,178 - 167,142,238	EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)

ACI/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

ACI/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

ACI/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

BBDP/Wor (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

BN/SsN (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Buf/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

COP/CrCrl (MCW & UW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob) University of Wisconsin (Dr. James Shull)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Charles River Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)

F344/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

F344/NRrrc (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

FHH/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHH/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

FHL/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHL/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

GH/OmrMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

GK/Ox (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LE/Stm (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/Crl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/NCrlBR (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LH/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LL/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LN/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

M520/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

MHS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MNS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MR/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

SBH/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBH/Ygl sequenced by MCW

SBH/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SBN/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBN/Ygl sequenced by MCW

SBN/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHR/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHRSP/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SR/JrHsd (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Harlan Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SR/JrHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/Jr (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/JrHsdMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SS/JrHsdMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WAG/Rij (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

WKY/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WN/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:68328	AgrOrtholog
Ensembl Genes	ENSRNOG00000017693	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000024054	ENTREZGENE, UniProtKB/Swiss-Prot
	ENSRNOP00000068562	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000024054	ENTREZGENE, UniProtKB/Swiss-Prot
	ENSRNOT00000089314	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7127817	IMAGE-MGC_LOAD
InterPro	Fru_transpt_5	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	MFS_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	MFS_sugar_transport-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	MFS_trans_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Sugar/inositol_transpt	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Sugar_transporter_CS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:65197	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:187361	IMAGE-MGC_LOAD
NCBI Gene	65197	ENTREZGENE
Pfam	Sugar_tr	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Slc2a5	PhenoGen
PRINTS	GLUCTRSPORT5	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SUGRTRNSPORT	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	MFS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SUGAR_TRANSPORT_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SUGAR_TRANSPORT_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF103473	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR	TC220761
TIGRFAMs	TIGR00879	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A0G2JT43_RAT	UniProtKB/TrEMBL
	B1WBQ4_RAT	UniProtKB/TrEMBL
	GTR5_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-02-24	Slc2a5	solute carrier family 2 member 5	Slc2a5	solute carrier family 2 (facilitated glucose/fructose transporter), member 5	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-02-18	Slc2a5	solute carrier family 2 (facilitated glucose/fructose transporter), member 5	Slc2a5	solute carrier family 2, member 5	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2002-06-10	Slc2a5	solute carrier family 2, member 5			Name updated	70584	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_expression	mRNA expressed in small intestine and kidney during prenatal period	68309
gene_homology	aa sequence shares 81.5% identity with human SLC2A5 (GLUT5)	68309
gene_protein	predicted protein contains 502 aa residues	68309
gene_regulation	mRNA expression upregulated in small intestine after prolonged high-fructose diet	68310

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD