Slc2a5 (solute carrier family 2 member 5) - Rat Genome Database

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Gene: Slc2a5 (solute carrier family 2 member 5) Rattus norvegicus
Analyze
Symbol: Slc2a5
Name: solute carrier family 2 member 5
RGD ID: 68328
Description: Enables fructose binding activity and fructose transmembrane transporter activity. Involved in cellular response to fructose stimulus; hexose transmembrane transport; and metanephric proximal tubule development. Located in sarcolemma. Orthologous to human SLC2A5 (solute carrier family 2 member 5); INTERACTS WITH 17beta-estradiol; 2,3,4,7,8-Pentachlorodibenzofuran; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: fructose transporter; glucose transporter type 5, small intestine; GLUT-5; solute carrier family 2 (facilitated glucose transporter) member 5; solute carrier family 2 (facilitated glucose transporter), member 5; solute carrier family 2 (facilitated glucose/fructose transporter), member 5; solute carrier family 2, facilitated glucose transporter member 5; solute carrier family 2, member 5
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85165,857,412 - 165,892,928 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5165,866,172 - 165,894,038 (+)EnsemblGRCr8
mRatBN7.25160,583,055 - 160,609,994 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5160,583,234 - 160,611,106 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5163,299,711 - 163,326,461 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05165,121,924 - 165,148,813 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05165,078,270 - 165,105,019 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05167,142,182 - 167,174,203 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5167,141,875 - 167,174,310 (+)Ensemblrn6Rnor6.0
Rnor_5.05170,782,871 - 170,808,467 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45167,240,442 - 167,285,761 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5158,844,838 - 158,869,525 (+)NCBICelera
RGSC_v3.15167,250,629 - 167,295,948 (+)NCBI
Cytogenetic Map5q36NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,4,7,8-Pentachlorodibenzofuran  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
3',5'-cyclic AMP  (EXP,ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5-triiodo-L-thyronine  (EXP)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
acetamide  (EXP)
acrylamide  (ISO)
actinomycin D  (EXP,ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
amphotericin B  (ISO)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic acid  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bucladesine  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP)
calcitriol  (ISO)
carbon nanotube  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
clofibrate  (EXP,ISO)
colforsin daropate hydrochloride  (EXP,ISO)
Cuprizon  (EXP)
curcumin  (ISO)
cycloheximide  (EXP)
cyclosporin A  (EXP)
D-glucose  (EXP,ISO)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (ISO)
diethyl maleate  (EXP)
dimethylarsinic acid  (ISO)
epoxiconazole  (ISO)
ethyl methanesulfonate  (ISO)
formaldehyde  (ISO)
fructose  (EXP,ISO)
fulvestrant  (ISO)
furan  (ISO)
gentamycin  (EXP)
glucose  (EXP,ISO)
GW 4064  (ISO)
hexadecanoic acid  (ISO)
hydroquinone  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
indometacin  (ISO)
iron atom  (EXP,ISO)
iron(0)  (EXP,ISO)
ketamine  (EXP)
lead diacetate  (EXP)
levonorgestrel  (ISO)
LY294002  (EXP)
metformin  (EXP)
methamphetamine  (ISO)
methylarsonic acid  (ISO)
mifepristone  (EXP)
mirtazapine  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
Nutlin-3  (ISO)
ochratoxin A  (EXP)
okadaic acid  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenformin  (EXP)
phenobarbital  (EXP,ISO)
pioglitazone  (ISO)
pirinixic acid  (EXP,ISO)
propiconazole  (EXP)
rotenone  (EXP)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sodium fluoride  (ISO)
Soman  (EXP)
sucrose  (EXP)
sulforaphane  (ISO)
tamibarotene  (ISO)
tamoxifen  (EXP)
testosterone  (EXP)
testosterone undecanoate  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
toluene  (EXP)
triadimefon  (EXP)
tributylstannane  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (EXP,ISO)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (EXP)
valdecoxib  (EXP)
valproic acid  (EXP,ISO)
vancomycin  (ISO)
wortmannin  (EXP)
zinc atom  (EXP,ISO)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
apical plasma membrane  (IEA,ISO,ISS)
membrane  (IEA)
plasma membrane  (IBA,IDA,IEA,ISO)
sarcolemma  (IDA,IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Biochemical and functional characterization of the GLUT5 fructose transporter in rat skeletal muscle. Darakhshan F, etal., Biochem J. 1998 Dec 1;336 ( Pt 2):361-6.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Cloning and increased expression with fructose feeding of rat jejunal GLUT5. Inukai K, etal., Endocrinology 1993 Nov;133(5):2009-14.
5. GLUT-5 expression in neonatal rats: crypt-villus location and age-dependent regulation. Jiang L, etal., Am J Physiol Gastrointest Liver Physiol 2001 Sep;281(3):G666-74.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Renogenic characterization and in vitro differentiation of rat amniotic fluid stem cells into renal proximal tubular- and juxtaglomerular-like cells. Minocha E, etal., In Vitro Cell Dev Biol Anim. 2019 Feb;55(2):138-147. doi: 10.1007/s11626-018-00315-2. Epub 2019 Jan 15.
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. Structure and mechanism of the mammalian fructose transporter GLUT5. Nomura N, etal., Nature. 2015 Oct 15;526(7573):397-401. doi: 10.1038/nature14909. Epub 2015 Sep 30.
10. Sequence, tissue distribution, and functional characterization of the rat fructose transporter GLUT5. Rand EB, etal., Am J Physiol 1993 Jun;264(6 Pt 1):G1169-76.
11. GOA pipeline RGD automated data pipeline
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
15. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:12914929   PMID:15489334   PMID:16581195   PMID:16627065   PMID:17485832   PMID:17947353   PMID:18154936   PMID:18496516   PMID:18556366   PMID:19056867   PMID:19091748   PMID:19956534  
PMID:21222652   PMID:23376485   PMID:23533145   PMID:26071406   PMID:28083649  


Genomics

Comparative Map Data
Slc2a5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85165,857,412 - 165,892,928 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5165,866,172 - 165,894,038 (+)EnsemblGRCr8
mRatBN7.25160,583,055 - 160,609,994 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5160,583,234 - 160,611,106 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5163,299,711 - 163,326,461 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05165,121,924 - 165,148,813 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05165,078,270 - 165,105,019 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05167,142,182 - 167,174,203 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5167,141,875 - 167,174,310 (+)Ensemblrn6Rnor6.0
Rnor_5.05170,782,871 - 170,808,467 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45167,240,442 - 167,285,761 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5158,844,838 - 158,869,525 (+)NCBICelera
RGSC_v3.15167,250,629 - 167,295,948 (+)NCBI
Cytogenetic Map5q36NCBI
SLC2A5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3819,035,106 - 9,094,195 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl19,035,106 - 9,088,478 (-)Ensemblhg38GRCh38
GRCh3719,095,165 - 9,132,318 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3619,019,594 - 9,052,257 (-)NCBIBuild 36Build 36hg18NCBI36
Build 3419,031,272 - 9,063,936NCBI
Celera18,205,681 - 8,257,881 (-)NCBICelera
Cytogenetic Map1p36.23NCBI
HuRef18,246,781 - 8,279,898 (-)NCBIHuRef
CHM1_119,086,735 - 9,120,070 (-)NCBICHM1_1
T2T-CHM13v2.018,568,756 - 8,627,452 (-)NCBIT2T-CHM13v2.0
Slc2a5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394150,203,801 - 150,228,625 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4150,203,740 - 150,228,626 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm384150,119,344 - 150,144,168 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4150,119,283 - 150,144,169 (+)Ensemblmm10GRCm38
MGSCv374149,493,453 - 149,518,277 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv364148,963,144 - 148,987,968 (+)NCBIMGSCv36mm8
Celera4152,395,331 - 152,418,947 (+)NCBICelera
Cytogenetic Map4E2NCBI
cM Map480.97NCBI
Slc2a5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554864,194,833 - 4,211,377 (+)Ensembl
ChiLan1.0NW_0049554864,194,568 - 4,208,568 (+)NCBIChiLan1.0ChiLan1.0
SLC2A5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21219,145,117 - 219,196,791 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11217,789,862 - 217,841,544 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v017,792,361 - 7,840,634 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.119,028,790 - 9,078,509 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl19,028,790 - 9,078,509 (-)EnsemblpanPan2panpan1.1
LOC489640
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1562,417,234 - 62,444,903 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl562,417,591 - 62,442,922 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha562,434,685 - 62,454,581 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0562,644,215 - 62,664,060 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl562,644,215 - 62,664,372 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1562,642,371 - 62,662,203 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0562,506,640 - 62,526,482 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0562,910,582 - 62,930,423 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Slc2a5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505832,741,273 - 32,767,573 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366233,226,515 - 3,249,914 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366233,226,533 - 3,249,909 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC2A5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl669,507,830 - 69,535,371 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1669,507,829 - 69,535,794 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
SLC2A5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120122,669,220 - 122,714,708 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20122,683,373 - 122,716,540 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605426,700,362 - 26,733,757 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc2a5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248183,135,422 - 3,155,698 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248183,132,345 - 3,156,184 (+)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Slc2a5
227 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:472
Count of miRNA genes:248
Interacting mature miRNAs:292
Transcripts:ENSRNOT00000024054
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5124965598166875058Rat
631272Lanf1Left ventricular atrial natriuretic factor QTL 112heart left ventricle natriuretic peptide A amount (VT:0010596)heart left ventricle natriuretic peptide A level (CMO:0002165)5151113452166875058Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
2302369Scl60Serum cholesterol level QTL 603.13blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)5143608201161165651Rat
631562Apr2Acute phase response QTL 23.7blood murinoglobulin 1 amount (VT:0010597)plasma murinoglobulin 1 level (CMO:0001931)5135927956166875058Rat
634349Bp139Blood pressure QTL 1390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5128924607166875058Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5135929696166875058Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5126424772166875058Rat
1549904Neuinf1Neuroinflammation QTL 130nervous system integrity trait (VT:0010566)blood T lymphocyte count (CMO:0000110)5154828214166875058Rat
738018Anxrr4Anxiety related response QTL 45.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)5130130159166875058Rat
2313096Bmd78Bone mineral density QTL 783.10.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)5144377876161317411Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5128506074166875058Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5131345754166875058Rat
1354631Swd2Spike wave discharge measurement QTL 23.640.0002brain electrophysiology trait (VT:0010557)brain total spike-and-wave discharge duration (CMO:0001740)5151113452164465185Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5127798274166875058Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5132717196165560427Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5121846814166846814Rat
1298090Bp155Blood pressure QTL 1553.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)5151006154161165494Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5127798274166875058Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5128506074166875058Rat
1331721Bp210Blood pressure QTL 2103.413arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5143069996166846814Rat

Markers in Region
BE119358  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.05167,168,284 - 167,168,462NCBIRnor6.0
RGSC_v3.45167,279,774 - 167,279,951UniSTSRGSC3.4
Celera5158,863,573 - 158,863,750UniSTS
RH 3.4 Map51115.2UniSTS
Cytogenetic Map5q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 63 165 91 90 59 30 59 6 290 126 11 141 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000024054   ⟹   ENSRNOP00000024054
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5165,866,172 - 165,892,930 (+)Ensembl
mRatBN7.2 Ensembl5160,583,238 - 160,609,994 (+)Ensembl
Rnor_6.0 Ensembl5167,142,182 - 167,174,203 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000089314   ⟹   ENSRNOP00000068562
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5165,870,316 - 165,894,038 (+)Ensembl
mRatBN7.2 Ensembl5160,587,377 - 160,611,106 (+)Ensembl
Rnor_6.0 Ensembl5167,141,875 - 167,174,310 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000098275   ⟹   ENSRNOP00000078805
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5165,870,316 - 165,892,930 (+)Ensembl
mRatBN7.2 Ensembl5160,587,377 - 160,609,994 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000110540   ⟹   ENSRNOP00000085564
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5165,866,172 - 165,893,235 (+)Ensembl
mRatBN7.2 Ensembl5160,583,234 - 160,610,102 (+)Ensembl
RefSeq Acc Id: NM_031741   ⟹   NP_113929
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85165,866,179 - 165,892,928 (+)NCBI
mRatBN7.25160,583,238 - 160,609,994 (+)NCBI
Rnor_6.05167,142,182 - 167,174,203 (+)NCBI
Rnor_5.05170,782,871 - 170,808,467 (+)NCBI
RGSC_v3.45167,240,442 - 167,285,761 (+)RGD
Celera5158,844,838 - 158,869,525 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063288368   ⟹   XP_063144438
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85165,857,412 - 165,892,928 (+)NCBI
RefSeq Acc Id: NP_113929   ⟸   NM_031741
- UniProtKB: A0A8I5ZM52 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000024054   ⟸   ENSRNOT00000024054
Ensembl Acc Id: ENSRNOP00000068562   ⟸   ENSRNOT00000089314
Ensembl Acc Id: ENSRNOP00000078805   ⟸   ENSRNOT00000098275
Ensembl Acc Id: ENSRNOP00000085564   ⟸   ENSRNOT00000110540
RefSeq Acc Id: XP_063144438   ⟸   XM_063288368
- Peptide Label: isoform X1
- UniProtKB: P43427 (UniProtKB/Swiss-Prot),   B1WBQ4 (UniProtKB/TrEMBL),   A0A8I5ZM52 (UniProtKB/TrEMBL)
Protein Domains
Major facilitator superfamily (MFS) profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P43427-F1-model_v2 AlphaFold P43427 1-502 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694279
Promoter ID:EPDNEW_R4804
Type:single initiation site
Name:Slc2a5_1
Description:solute carrier family 2 member 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05167,142,178 - 167,142,238EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:68328 AgrOrtholog
BioCyc Gene G2FUF-39081 BioCyc
Ensembl Genes ENSRNOG00000017693 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000024054 ENTREZGENE
  ENSRNOT00000024054.6 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1250.20 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7127817 IMAGE-MGC_LOAD
InterPro Fru_transpt_5 UniProtKB/Swiss-Prot
  GLUT UniProtKB/Swiss-Prot
  MFS_dom UniProtKB/Swiss-Prot
  MFS_sugar_transport-like UniProtKB/Swiss-Prot
  MFS_trans_sf UniProtKB/Swiss-Prot
  Sugar/inositol_transpt UniProtKB/Swiss-Prot
  Sugar_transporter_CS UniProtKB/Swiss-Prot
KEGG Report rno:65197 UniProtKB/Swiss-Prot
MGC_CLONE MGC:187361 IMAGE-MGC_LOAD
NCBI Gene 65197 ENTREZGENE
PANTHER PTHR23503 UniProtKB/Swiss-Prot
  SOLUTE CARRIER FAMILY 2, FACILITATED GLUCOSE TRANSPORTER MEMBER 5 UniProtKB/Swiss-Prot
Pfam Sugar_tr UniProtKB/Swiss-Prot
PhenoGen Slc2a5 PhenoGen
PRINTS GLUCTRSPORT5 UniProtKB/Swiss-Prot
  SUGRTRNSPORT UniProtKB/Swiss-Prot
PROSITE MFS UniProtKB/Swiss-Prot
  SUGAR_TRANSPORT_1 UniProtKB/Swiss-Prot
  SUGAR_TRANSPORT_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000017693 RatGTEx
Superfamily-SCOP SSF103473 UniProtKB/Swiss-Prot
TIGR TC220761
UniProt A0A0G2JT43_RAT UniProtKB/TrEMBL
  A0A8I5ZM52 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A4B7_RAT UniProtKB/TrEMBL
  A6IUC8_RAT UniProtKB/TrEMBL
  A6IUC9_RAT UniProtKB/TrEMBL
  B1WBQ4 ENTREZGENE, UniProtKB/TrEMBL
  GTR5_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-24 Slc2a5  solute carrier family 2 member 5  Slc2a5  solute carrier family 2 (facilitated glucose/fructose transporter), member 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-18 Slc2a5  solute carrier family 2 (facilitated glucose/fructose transporter), member 5  Slc2a5  solute carrier family 2, member 5   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Slc2a5  solute carrier family 2, member 5       Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression mRNA expressed in small intestine and kidney during prenatal period 68309
gene_homology aa sequence shares 81.5% identity with human SLC2A5 (GLUT5) 68309
gene_protein predicted protein contains 502 aa residues 68309
gene_regulation mRNA expression upregulated in small intestine after prolonged high-fructose diet 68310