Nphp4 (nephrocystin 4) - Rat Genome Database

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Gene: Nphp4 (nephrocystin 4) Rattus norvegicus
Analyze
Symbol: Nphp4
Name: nephrocystin 4
RGD ID: 1560172
Description: Predicted to be involved in negative regulation of canonical Wnt signaling pathway; positive regulation of bicellular tight junction assembly; and protein localization to ciliary transition zone. Predicted to act upstream of or within several processes, including flagellated sperm motility; photoreceptor cell maintenance; and photoreceptor cell outer segment organization. Located in ciliary basal body. Human ortholog(s) of this gene implicated in Joubert syndrome 4; Senior-Loken syndrome; congenital heart disease; nephronophthisis; and nephronophthisis 4. Orthologous to human NPHP4 (nephrocystin 4); INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC313749; MGC125230; nephrocystin-4; nephronophthisis 4; nephronophthisis 4 (juvenile) homolog; nephronophthisis 4 (juvenile) homolog (human); similar to mKIAA0673 protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85168,270,522 - 168,356,393 (+)NCBIGRCr8
mRatBN7.25162,986,157 - 163,073,708 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5162,988,370 - 163,073,706 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5165,691,473 - 165,776,590 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05167,513,074 - 167,598,197 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05167,475,281 - 167,560,405 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05169,647,581 - 169,744,662 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5169,659,188 - 169,744,660 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05173,201,362 - 173,298,422 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45169,711,038 - 169,797,486 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera5161,218,067 - 161,302,859 (+)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


References

References - curated
# Reference Title Reference Citation
1. Mutations in the gene encoding the basal body protein RPGRIP1L, a nephrocystin-4 interactor, cause Joubert syndrome. Arts HH, etal., Nat Genet. 2007 Jul;39(7):882-8. Epub 2007 Jun 10.
2. NPHP4 variants are associated with pleiotropic heart malformations. French VM, etal., Circ Res. 2012 Jun 8;110(12):1564-74. doi: 10.1161/CIRCRESAHA.112.269795. Epub 2012 May 1.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Clinical and histological presentation of 3 siblings with mutations in the NPHP4 gene. Hoefele J, etal., Am J Kidney Dis. 2004 Feb;43(2):358-64.
5. Mutational analysis of the NPHP4 gene in 250 patients with nephronophthisis. Hoefele J, etal., Hum Mutat. 2005 Apr;25(4):411.
6. Evidence of oligogenic inheritance in nephronophthisis. Hoefele J, etal., J Am Soc Nephrol. 2007 Oct;18(10):2789-95. Epub 2007 Sep 12.
7. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
8. A gene mutated in nephronophthisis and retinitis pigmentosa encodes a novel protein, nephroretinin, conserved in evolution. Otto E, etal., Am J Hum Genet. 2002 Nov;71(5):1161-7. Epub 2002 Aug 29.
9. Mutation analysis in nephronophthisis using a combined approach of homozygosity mapping, CEL I endonuclease cleavage, and direct sequencing. Otto EA, etal., Hum Mutat. 2008 Mar;29(3):418-26.
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Comprehensive gene review and curation RGD comprehensive gene curation
13. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:19755384   PMID:20169535   PMID:21052544   PMID:21078623   PMID:21399614   PMID:21565611   PMID:22654112   PMID:29899041  


Genomics

Comparative Map Data
Nphp4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85168,270,522 - 168,356,393 (+)NCBIGRCr8
mRatBN7.25162,986,157 - 163,073,708 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5162,988,370 - 163,073,706 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5165,691,473 - 165,776,590 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05167,513,074 - 167,598,197 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05167,475,281 - 167,560,405 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05169,647,581 - 169,744,662 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5169,659,188 - 169,744,660 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05173,201,362 - 173,298,422 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45169,711,038 - 169,797,486 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera5161,218,067 - 161,302,859 (+)NCBICelera
Cytogenetic Map5q36NCBI
NPHP4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3815,862,811 - 5,992,425 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl15,862,811 - 5,992,473 (-)EnsemblGRCh38hg38GRCh38
GRCh3715,922,871 - 6,052,485 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3615,845,457 - 5,975,118 (-)NCBINCBI36Build 36hg18NCBI36
Build 3415,857,135 - 5,986,797NCBI
Celera15,037,702 - 5,167,377 (-)NCBICelera
Cytogenetic Map1p36.31NCBI
HuRef15,071,502 - 5,201,940 (-)NCBIHuRef
CHM1_115,911,568 - 6,041,216 (-)NCBICHM1_1
T2T-CHM13v2.015,387,041 - 5,518,608 (-)NCBIT2T-CHM13v2.0
Nphp4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394152,561,163 - 152,647,641 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4152,561,163 - 152,647,640 (+)EnsemblGRCm39 Ensembl
GRCm384152,476,706 - 152,563,184 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4152,476,706 - 152,563,183 (+)EnsemblGRCm38mm10GRCm38
MGSCv374151,852,251 - 151,937,293 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364151,321,942 - 151,406,934 (+)NCBIMGSCv36mm8
Celera4154,764,281 - 154,849,333 (+)NCBICelera
Cytogenetic Map4E2NCBI
cM Map483.14NCBI
Nphp4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554866,448,442 - 6,547,488 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554866,442,058 - 6,547,451 (+)NCBIChiLan1.0ChiLan1.0
NPHP4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21222,234,457 - 222,370,369 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11220,876,170 - 221,012,339 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v014,620,593 - 4,756,363 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.115,878,739 - 6,012,869 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl15,878,739 - 6,012,864 (-)Ensemblpanpan1.1panPan2
NPHP4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1559,819,236 - 59,936,220 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl559,814,274 - 59,929,386 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha559,830,501 - 59,946,241 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0560,022,493 - 60,152,631 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl560,035,558 - 60,152,688 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1560,035,853 - 60,151,600 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0559,902,253 - 60,018,001 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0560,303,659 - 60,419,425 (-)NCBIUU_Cfam_GSD_1.0
Nphp4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505830,316,914 - 30,418,643 (-)NCBIHiC_Itri_2
SpeTri2.0NW_004936623802,152 - 904,198 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NPHP4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl666,815,281 - 66,928,146 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1666,815,282 - 66,928,245 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2661,821,151 - 61,829,018 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NPHP4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120125,739,075 - 125,878,088 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20125,744,295 - 125,874,482 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605429,894,007 - 30,031,596 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nphp4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248185,327,038 - 5,432,901 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248185,325,946 - 5,432,290 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Nphp4
395 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:54
Count of miRNA genes:46
Interacting mature miRNAs:54
Transcripts:ENSRNOT00000066623
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5121846814166846814Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5124965598166875058Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5126424772166875058Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5127798274166875058Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5127798274166875058Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5128506074166875058Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5128506074166875058Rat
634349Bp139Blood pressure QTL 1390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5128924607166875058Rat
738018Anxrr4Anxiety related response QTL 45.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)5130130159166875058Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5131345754166875058Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5132717196165560427Rat
631562Apr2Acute phase response QTL 23.7blood murinoglobulin 1 amount (VT:0010597)plasma murinoglobulin 1 level (CMO:0001931)5135927956166875058Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5135929696166875058Rat
1331721Bp210Blood pressure QTL 2103.413arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5143069996166846814Rat
1354631Swd2Spike wave discharge measurement QTL 23.640.0002brain electrophysiology trait (VT:0010557)brain total spike-and-wave discharge duration (CMO:0001740)5151113452164465185Rat
631272Lanf1Left ventricular atrial natriuretic factor QTL 112heart left ventricle natriuretic peptide A amount (VT:0010596)heart left ventricle natriuretic peptide A level (CMO:0002165)5151113452166875058Rat
1549904Neuinf1Neuroinflammation QTL 130nervous system integrity trait (VT:0010566)blood T lymphocyte count (CMO:0000110)5154828214166875058Rat

Markers in Region
D5Rat244  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25163,026,006 - 163,026,191 (+)MAPPERmRatBN7.2
Rnor_6.05169,696,938 - 169,697,122NCBIRnor6.0
Rnor_5.05173,250,700 - 173,250,884UniSTSRnor5.0
RGSC_v3.45169,748,820 - 169,749,004UniSTSRGSC3.4
Celera5161,255,576 - 161,255,760UniSTS
SHRSP x BN Map597.9299UniSTS
SHRSP x BN Map597.9299RGD
Cytogenetic Map5q36UniSTS
RH94672  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25162,987,799 - 162,987,983 (+)MAPPERmRatBN7.2
Rnor_6.05169,658,618 - 169,658,801NCBIRnor6.0
Rnor_5.05173,212,381 - 173,212,564UniSTSRnor5.0
RGSC_v3.45169,710,468 - 169,710,651UniSTSRGSC3.4
Celera5161,217,497 - 161,217,680UniSTS
RH 3.4 Map51140.7UniSTS
Cytogenetic Map5q36UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 27 8 13
Low 3 34 26 10 19 10 5 8 47 27 28 11 5
Below cutoff 9 31 31 31 3 3 3

Sequence


RefSeq Acc Id: ENSRNOT00000066623   ⟹   ENSRNOP00000063188
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5162,988,370 - 163,073,706 (+)Ensembl
Rnor_6.0 Ensembl5169,659,188 - 169,744,660 (+)Ensembl
RefSeq Acc Id: NM_001037650   ⟹   NP_001032739
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85168,271,073 - 168,356,393 (+)NCBI
mRatBN7.25162,988,370 - 163,073,706 (+)NCBI
Rnor_6.05169,659,188 - 169,744,660 (+)NCBI
Rnor_5.05173,201,362 - 173,298,422 (+)NCBI
RGSC_v3.45169,711,038 - 169,797,486 (+)RGD
Celera5161,218,067 - 161,302,859 (+)RGD
Sequence:
RefSeq Acc Id: XM_006239465   ⟹   XP_006239527
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85168,270,522 - 168,356,391 (+)NCBI
mRatBN7.25162,988,008 - 163,073,705 (+)NCBI
Rnor_6.05169,658,875 - 169,744,662 (+)NCBI
Rnor_5.05173,201,362 - 173,298,422 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017593435   ⟹   XP_017448924
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85168,270,738 - 168,356,391 (+)NCBI
mRatBN7.25162,988,035 - 163,073,705 (+)NCBI
Rnor_6.05169,658,903 - 169,744,662 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039110104   ⟹   XP_038966032
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85168,270,914 - 168,356,391 (+)NCBI
mRatBN7.25162,988,206 - 163,073,708 (+)NCBI
RefSeq Acc Id: XM_039110105   ⟹   XP_038966033
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85168,270,522 - 168,356,391 (+)NCBI
mRatBN7.25162,988,008 - 163,073,697 (+)NCBI
RefSeq Acc Id: NP_001032739   ⟸   NM_001037650
- UniProtKB: G3V9Y6 (UniProtKB/TrEMBL),   A6IUI8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006239527   ⟸   XM_006239465
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017448924   ⟸   XM_017593435
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000063188   ⟸   ENSRNOT00000066623
RefSeq Acc Id: XP_038966033   ⟸   XM_039110105
- Peptide Label: isoform X2
- UniProtKB: G3V9Y6 (UniProtKB/TrEMBL),   A6IUI8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038966032   ⟸   XM_039110104
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-G3V9Y6-F1-model_v2 AlphaFold G3V9Y6 1-1428 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1560172 AgrOrtholog
BioCyc Gene G2FUF-39002 BioCyc
Ensembl Genes ENSRNOG00000011967 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000066623 ENTREZGENE
  ENSRNOT00000066623.2 UniProtKB/TrEMBL
InterPro NPHP4 UniProtKB/TrEMBL
KEGG Report rno:313749 UniProtKB/TrEMBL
NCBI Gene 313749 ENTREZGENE
PANTHER NEPHROCYSTIN-4 UniProtKB/TrEMBL
  PTHR31043 UniProtKB/TrEMBL
PhenoGen Nphp4 PhenoGen
RatGTEx ENSRNOG00000011967 RatGTEx
UniProt A6IUI8 ENTREZGENE, UniProtKB/TrEMBL
  A6IUJ1_RAT UniProtKB/TrEMBL
  G3V9Y6 ENTREZGENE, UniProtKB/TrEMBL
  Q32Q04_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-29 Nphp4  nephrocystin 4  Nphp4  nephronophthisis 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-01-22 Nphp4  nephronophthisis 4  Nphp4  nephronophthisis 4 (juvenile) homolog (human)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-05-27 Nphp4  nephronophthisis 4 (juvenile) homolog (human)  Nphp4  nephronophthisis 4   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-05 Nphp4  nephronophthisis 4   LOC313749  similar to mKIAA0673 protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-02-09 LOC313749  similar to mKIAA0673 protein      Symbol and Name status set to provisional 70820 PROVISIONAL