Per3 (period circadian regulator 3) - Rat Genome Database

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Gene: Per3 (period circadian regulator 3) Rattus norvegicus
Analyze
Symbol: Per3
Name: period circadian regulator 3
RGD ID: 621581
Description: Predicted to enable enzyme binding activity; transcription cis-regulatory region binding activity; and transcription corepressor binding activity. Predicted to be involved in several processes, including entrainment of circadian clock by photoperiod; protein stabilization; and regulation of gene expression. Predicted to act upstream of or within circadian rhythm. Predicted to be active in cytoplasm and nucleus. Biomarker of alcohol use disorder. Human ortholog(s) of this gene implicated in advanced sleep phase syndrome; advanced sleep phase syndrome 3; and bipolar disorder. Orthologous to human PER3 (period circadian regulator 3); INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: circadian clock protein PERIOD 3; period circadian clock 3; period circadian protein homolog 3; period homolog 3; period homolog 3 (Drosophila); period3; rper3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85166,740,914 - 166,778,243 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5166,743,050 - 166,777,999 (-)EnsemblGRCr8
mRatBN7.25161,460,228 - 161,495,404 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5161,459,533 - 161,495,607 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5164,177,009 - 164,211,658 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05165,993,418 - 166,028,287 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05165,955,653 - 165,990,302 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05168,088,126 - 168,123,482 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5168,086,998 - 168,123,395 (-)Ensemblrn6Rnor6.0
Rnor_5.05171,665,221 - 171,700,529 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45168,152,693 - 168,187,442 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5159,712,426 - 159,747,156 (-)NCBICelera
RGSC_v3.15168,163,026 - 168,197,630 (-)NCBI
Cytogenetic Map5q36NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-D  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (EXP,ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
azoxystrobin  (EXP)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butanal  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcium silicate  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloroprene  (EXP)
chlorpyrifos  (EXP,ISO)
choline  (ISO)
chrysene  (ISO)
cisplatin  (ISO)
cocaine  (ISO)
cocaine hydrochloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
D-glucose  (ISO)
deoxynivalenol  (ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (ISO)
dichloroacetic acid  (ISO)
dichloromethane  (ISO)
dicrotophos  (ISO)
diethyl maleate  (EXP)
diethylstilbestrol  (EXP)
dioxygen  (EXP,ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
Erionite  (ISO)
ethanol  (ISO)
folic acid  (ISO)
FR900359  (ISO)
fructose  (ISO)
furan  (EXP)
gentamycin  (EXP)
glucose  (ISO)
glyphosate  (EXP,ISO)
gold atom  (ISO)
gold(0)  (ISO)
imidacloprid  (EXP)
iron dichloride  (ISO)
isoprenaline  (ISO)
ketoconazole  (EXP)
L-methionine  (ISO)
lead(0)  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
metacetamol  (ISO)
methamphetamine  (EXP)
methotrexate  (ISO)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
ochratoxin A  (ISO)
okadaic acid  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
parathion  (ISO)
pentanal  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
permethrin  (EXP,ISO)
phenethyl caffeate  (EXP)
phenethyl isothiocyanate  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (ISO)
propanal  (ISO)
ritodrine  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
Se-methyl-L-selenocysteine  (EXP)
Se-methylselenocysteine  (EXP)
selenium atom  (ISO)
senecionine  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
styrene  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
thiabendazole  (EXP)
thioacetamide  (EXP)
titanium dioxide  (EXP)
tremolite asbestos  (ISO)
tributylstannane  (ISO)
trichloroethene  (EXP)
triphenyl phosphate  (EXP,ISO)
troglitazone  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
vorinostat  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IEA,ISO,ISS)
nucleus  (IBA,IEA,ISO,ISS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Clock genes polymorphisms in male bipolar patients with comorbid alcohol abuse. Banach E, etal., J Affect Disord. 2018 Dec 1;241:142-146. doi: 10.1016/j.jad.2018.07.080. Epub 2018 Jul 31.
2. Chronic ethanol consumption impairs the circadian rhythm of pro-opiomelanocortin and period genes mRNA expression in the hypothalamus of the male rat. Chen CP, etal., J Neurochem. 2004 Mar;88(6):1547-54. doi: 10.1046/j.1471-4159.2003.02300.x.
3. Prenatal ethanol exposure alters the expression of period genes governing the circadian function of beta-endorphin neurons in the hypothalamus. Chen CP, etal., J Neurochem. 2006 May;97(4):1026-33. doi: 10.1111/j.1471-4159.2006.03839.x.
4. Association of structural polymorphisms in the human period3 gene with delayed sleep phase syndrome. Ebisawa T, etal., EMBO Rep 2001 Apr;2(4):342-6.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Implications of circadian gene expression in kidney, liver and the effects of fasting on pharmacogenomic studies. Kita Y, etal., Pharmacogenetics 2002 Jan;12(1):55-65.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. GOA pipeline RGD automated data pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Effect of fluoxetine and cocaine on the expression of clock genes in the mouse hippocampus and striatum. Uz T, etal., Neuroscience. 2005;134(4):1309-16. doi: 10.1016/j.neuroscience.2005.05.003.
Additional References at PubMed
PMID:9989497   PMID:12843397   PMID:14564007   PMID:15917222   PMID:16267386   PMID:17346965   PMID:19716732   PMID:20738730   PMID:21957163   PMID:24439663   PMID:24577121   PMID:26903630  


Genomics

Comparative Map Data
Per3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85166,740,914 - 166,778,243 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5166,743,050 - 166,777,999 (-)EnsemblGRCr8
mRatBN7.25161,460,228 - 161,495,404 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5161,459,533 - 161,495,607 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5164,177,009 - 164,211,658 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05165,993,418 - 166,028,287 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05165,955,653 - 165,990,302 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05168,088,126 - 168,123,482 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5168,086,998 - 168,123,395 (-)Ensemblrn6Rnor6.0
Rnor_5.05171,665,221 - 171,700,529 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45168,152,693 - 168,187,442 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5159,712,426 - 159,747,156 (-)NCBICelera
RGSC_v3.15168,163,026 - 168,197,630 (-)NCBI
Cytogenetic Map5q36NCBI
PER3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3817,784,291 - 7,845,177 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl17,784,291 - 7,845,181 (+)Ensemblhg38GRCh38
GRCh3717,844,351 - 7,905,237 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3617,767,350 - 7,827,824 (+)NCBIBuild 36Build 36hg18NCBI36
Build 3417,779,028 - 7,839,503NCBI
Celera16,952,489 - 7,012,918 (+)NCBICelera
Cytogenetic Map1p36.23NCBI
HuRef16,993,003 - 7,053,532 (+)NCBIHuRef
CHM1_117,832,500 - 7,892,974 (+)NCBICHM1_1
T2T-CHM13v2.017,315,337 - 7,376,224 (+)NCBIT2T-CHM13v2.0
Per3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394151,081,475 - 151,129,167 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4151,088,109 - 151,129,122 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm384150,997,018 - 151,044,707 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4151,003,652 - 151,044,665 (-)Ensemblmm10GRCm38
MGSCv374150,377,764 - 150,418,731 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv364149,848,512 - 149,888,389 (-)NCBIMGSCv36mm8
Celera4153,279,480 - 153,320,397 (-)NCBICelera
Cytogenetic Map4E2NCBI
cM Map481.53NCBI
Per3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554865,059,773 - 5,101,637 (-)Ensembl
ChiLan1.0NW_0049554865,058,602 - 5,101,480 (-)NCBIChiLan1.0ChiLan1.0
PER3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21220,381,214 - 220,442,021 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11219,022,337 - 219,083,038 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v016,547,667 - 6,607,905 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.117,795,549 - 7,855,922 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl17,795,552 - 7,855,922 (+)EnsemblpanPan2panpan1.1
PER3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1561,445,580 - 61,499,393 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl561,445,461 - 61,498,499 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha561,454,281 - 61,508,079 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0561,662,394 - 61,716,172 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl561,662,356 - 61,716,152 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1561,661,665 - 61,715,387 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0561,526,094 - 61,579,868 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0561,929,781 - 61,983,527 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Per3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505831,805,406 - 31,853,491 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366232,290,614 - 2,336,634 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366232,291,211 - 2,362,693 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PER3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1668,487,634 - 68,548,718 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
PER3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120123,912,773 - 123,970,440 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20123,912,208 - 123,970,549 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605427,947,725 - 28,005,720 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Per3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248183,967,333 - 4,007,739 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248183,959,639 - 4,007,739 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Per3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v119,728,099 - 9,764,114 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Per3
159 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:157
Count of miRNA genes:128
Interacting mature miRNAs:139
Transcripts:ENSRNOT00000024932
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555124766172190305Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5130249266172190305Rat
631272Lanf1Left ventricular atrial natriuretic factor QTL 112heart left ventricle natriuretic peptide A amount (VT:0010596)heart left ventricle natriuretic peptide A level (CMO:0002165)5156396728167181764Rat
1354583Despr3Despair related QTL34.980.0002locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)5132930505172190305Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5141212838172190305Rat
1300119Bp180Blood pressure QTL 1803.82arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5149642129171146538Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5131708216172190305Rat
1549904Neuinf1Neuroinflammation QTL 130nervous system integrity trait (VT:0010566)blood T lymphocyte count (CMO:0000110)5160111176171146538Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)599905133172190305Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5133789363172190305Rat
1331803Rf32Renal function QTL 322.798kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)5134369199172190305Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)565089051166764498Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5136631198172190305Rat
1354631Swd2Spike wave discharge measurement QTL 23.640.0002brain electrophysiology trait (VT:0010557)brain total spike-and-wave discharge duration (CMO:0001740)5156396728172190305Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5133081618172190305Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5138002522170842766Rat
1581505Rf54Renal function QTL 54kidney physiology trait (VT:0002136)kidney 20-HETE level (CMO:0001854)5133270647172190305Rat
1298090Bp155Blood pressure QTL 1553.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)5156289283171137955Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5160071170172129029Rat
2317753Glom24Glomerulus QTL 243.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)5141764300172190305Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5133081618172190305Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5133789363172190305Rat
1331721Bp210Blood pressure QTL 2103.413arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5148093485172129029Rat
1581510Cm54Cardiac mass QTL 543.40.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)5125969677172190305Rat

Markers in Region
D5Mco10  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr85166,764,253 - 166,764,498 (+)Marker Load Pipeline
mRatBN7.25161,481,433 - 161,481,680 (+)MAPPERmRatBN7.2
Rnor_6.05168,109,415 - 168,109,659NCBIRnor6.0
Rnor_5.05171,686,510 - 171,686,754UniSTSRnor5.0
RGSC_v3.45168,173,896 - 168,174,140UniSTSRGSC3.4
RGSC_v3.45168,173,895 - 168,174,140RGDRGSC3.4
Celera5159,733,610 - 159,733,854UniSTS
RGSC_v3.15168,184,083 - 168,184,328RGD
Cytogenetic Map5q36UniSTS
BF419445  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25161,476,220 - 161,476,346 (+)MAPPERmRatBN7.2
Rnor_6.05168,104,117 - 168,104,242NCBIRnor6.0
Rnor_5.05171,681,212 - 171,681,337UniSTSRnor5.0
RGSC_v3.45168,168,684 - 168,168,809UniSTSRGSC3.4
Celera5159,728,417 - 159,728,542UniSTS
RH 3.4 Map51128.4UniSTS
Cytogenetic Map5q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 163 91 90 59 92 59 6 355 192 11 142 80 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000024932   ⟹   ENSRNOP00000024932
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5166,743,050 - 166,777,999 (-)Ensembl
mRatBN7.2 Ensembl5161,460,228 - 161,495,607 (-)Ensembl
Rnor_6.0 Ensembl5168,086,998 - 168,123,395 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000092747   ⟹   ENSRNOP00000076026
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5166,743,196 - 166,777,999 (-)Ensembl
mRatBN7.2 Ensembl5161,460,374 - 161,495,607 (-)Ensembl
Rnor_6.0 Ensembl5168,088,272 - 168,123,030 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000092840
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl5168,119,561 - 168,123,030 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000092912
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl5168,109,659 - 168,110,285 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000092923
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl5168,121,316 - 168,123,021 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000093063   ⟹   ENSRNOP00000075932
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl5168,112,376 - 168,120,179 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000093100
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl5168,121,998 - 168,122,977 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000093114
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl5168,121,329 - 168,121,640 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000108999   ⟹   ENSRNOP00000094435
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5166,743,050 - 166,777,999 (-)Ensembl
mRatBN7.2 Ensembl5161,459,533 - 161,495,295 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000135532   ⟹   ENSRNOP00000112573
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5166,743,567 - 166,777,999 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000171028   ⟹   ENSRNOP00000112514
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5166,744,534 - 166,777,999 (-)Ensembl
RefSeq Acc Id: NM_023978   ⟹   NP_076468
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85166,743,050 - 166,777,800 (-)NCBI
mRatBN7.25161,460,228 - 161,494,982 (-)NCBI
Rnor_6.05168,088,126 - 168,123,030 (-)NCBI
Rnor_5.05171,665,221 - 171,700,529 (-)NCBI
RGSC_v3.45168,152,693 - 168,187,442 (-)RGD
Celera5159,712,426 - 159,747,156 (-)RGD
Sequence:
RefSeq Acc Id: XM_006239504   ⟹   XP_006239566
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85166,740,914 - 166,778,243 (-)NCBI
mRatBN7.25161,460,244 - 161,495,402 (-)NCBI
Rnor_6.05168,088,190 - 168,123,482 (-)NCBI
Rnor_5.05171,665,221 - 171,700,529 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006239505   ⟹   XP_006239567
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85166,740,914 - 166,778,243 (-)NCBI
mRatBN7.25161,460,244 - 161,495,402 (-)NCBI
Rnor_6.05168,088,190 - 168,123,482 (-)NCBI
Rnor_5.05171,665,221 - 171,700,529 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063288459   ⟹   XP_063144529
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85166,740,914 - 166,774,204 (-)NCBI
RefSeq Acc Id: NP_076468   ⟸   NM_023978
- UniProtKB: G3V8D9 (UniProtKB/TrEMBL),   A6IUE8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006239567   ⟸   XM_006239505
- Peptide Label: isoform X2
- UniProtKB: G3V8D9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006239566   ⟸   XM_006239504
- Peptide Label: isoform X1
- UniProtKB: G3V8D9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000076026   ⟸   ENSRNOT00000092747
Ensembl Acc Id: ENSRNOP00000024932   ⟸   ENSRNOT00000024932
Ensembl Acc Id: ENSRNOP00000075932   ⟸   ENSRNOT00000093063
Ensembl Acc Id: ENSRNOP00000094435   ⟸   ENSRNOT00000108999
RefSeq Acc Id: XP_063144529   ⟸   XM_063288459
- Peptide Label: isoform X3
Ensembl Acc Id: ENSRNOP00000112514   ⟸   ENSRNOT00000171028
Ensembl Acc Id: ENSRNOP00000112573   ⟸   ENSRNOT00000135532
Protein Domains
PAC   PAS   Period circadian protein homolog PER 1-3 bHLH-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8CJE2-F1-model_v2 AlphaFold Q8CJE2 1-1119 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694287
Promoter ID:EPDNEW_R4812
Type:initiation region
Name:Per3_1
Description:period circadian regulator 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05168,123,419 - 168,123,479EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621581 AgrOrtholog
BioCyc Gene G2FUF-39044 BioCyc
Ensembl Genes ENSRNOG00000018413 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000024932 ENTREZGENE
Gene3D-CATH PAS domain UniProtKB/Swiss-Prot
InterPro PAS UniProtKB/Swiss-Prot
  PAS-like_dom_sf UniProtKB/Swiss-Prot
  PAS_fold_3 UniProtKB/Swiss-Prot
  Per1-3_PAS-A UniProtKB/Swiss-Prot
  Period_circadian-like_C UniProtKB/Swiss-Prot
  Period_circadian_regulator UniProtKB/Swiss-Prot
KEGG Report rno:78962 UniProtKB/Swiss-Prot
NCBI Gene 78962 ENTREZGENE
PANTHER PERIOD CIRCADIAN PROTEIN UniProtKB/Swiss-Prot
  PTHR11269:SF13 UniProtKB/Swiss-Prot
Pfam bHLH_PER UniProtKB/Swiss-Prot
  PAS_3 UniProtKB/Swiss-Prot
  Per3-like_PAS-A UniProtKB/Swiss-Prot
  Period_C UniProtKB/Swiss-Prot
PhenoGen Per3 PhenoGen
PROSITE PAS UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000018413 RatGTEx
SMART PAS UniProtKB/Swiss-Prot
Superfamily-SCOP SSF55785 UniProtKB/Swiss-Prot
UniProt A0A1B0GWU7_RAT UniProtKB/TrEMBL
  A0A8I6AN92_RAT UniProtKB/TrEMBL
  A0ABK0LNK9_RAT UniProtKB/TrEMBL
  A0ABK0M6N9_RAT UniProtKB/TrEMBL
  A6IUE8 ENTREZGENE, UniProtKB/TrEMBL
  A6IUF0_RAT UniProtKB/TrEMBL
  G3V8D9 ENTREZGENE, UniProtKB/TrEMBL
  PER3_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-10-09 Per3  period circadian regulator 3  Per3  period circadian clock 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-01-02 Per3  period circadian clock 3  Per3  period homolog 3 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Per3  period homolog 3 (Drosophila)      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Per3  period homolog 3 (Drosophila)      Symbol and Name status set to provisional 70820 PROVISIONAL