Gene: Per3 (period circadian regulator 3) Rattus norvegicus
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Symbol:
Per3
Name:
period circadian regulator 3
Description:
Predicted to have enzyme binding activity; transcription corepressor binding activity; and transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including entrainment of circadian clock by photoperiod; protein stabilization; and regulation of gene expression. Predicted to localize to cytoplasm and nucleus. Human ortholog(s) of this gene implicated in advanced sleep phase syndrome and advanced sleep phase syndrome 3. Orthologous to human PER3 (period circadian regulator 3); INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine.
Type:
protein-coding
RefSeq Status:
VALIDATED
Also known as:
circadian clock protein PERIOD 3; period circadian clock 3; period circadian protein homolog 3; period homolog 3; period homolog 3 (Drosophila); period3; rper3
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
PER3 (period circadian regulator 3) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, Treefam
Mus musculus (house mouse):
Per3 (period circadian clock 3) HGNC
Treefam, EggNOG, NCBI, OMA, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Per3 (period circadian regulator 3) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
PER3 (period circadian regulator 3) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
PER3 (period circadian regulator 3) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Per3 (period circadian regulator 3) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
PER3 (period circadian regulator 3) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):
PER3 (period circadian regulator 3) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):
Per3 (period circadian regulator 3) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Mus musculus (house mouse):
Per3 (period circadian clock 3)
Alliance
DIOPT (PANTHER|Ensembl Compara|OMA|PhylomeDB|OrthoFinder|InParanoid|OrthoInspector|Hieranoid|TreeFam)
Homo sapiens (human):
PER3 (period circadian regulator 3)
Alliance
DIOPT (PANTHER|HGNC|Ensembl Compara|OMA|PhylomeDB|OrthoFinder|InParanoid|OrthoInspector|Hieranoid|TreeFam)
Danio rerio (zebrafish):
per3 (period circadian clock 3)
Alliance
DIOPT (TreeFam|PhylomeDB)
Drosophila melanogaster (fruit fly):
per
Alliance
DIOPT (PANTHER|Ensembl Compara|OrthoFinder|InParanoid|OrthoInspector|Hieranoid)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 5 168,088,126 - 168,123,482 (-) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 5 168,086,998 - 168,123,395 (-) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 5 171,665,221 - 171,700,529 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 5 168,152,693 - 168,187,442 (-) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 5 168,163,026 - 168,197,630 (-) NCBI Celera 5 159,712,426 - 159,747,156 (-) NCBI Celera Cytogenetic Map 5 q36 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Imported Annotations - ClinVar
advanced sleep phase syndrome 3 ISO RGD:1352533 8554872 ClinVar Annotator: match by term: Advanced sleep phase syndrome, familial, 3 ClinVar PMID:25741868 , PMID:26903630 Neurodevelopmental Disorders ISO RGD:1352533 8554872 ClinVar Annotator: match by term: Neurodevelopmental disorder ClinVar PMID:25741868
Imported Annotations - CTD
advanced sleep phase syndrome 1 ISO RGD:1352533 11554173 CTD Direct Evidence: marker/mechanism CTD Breast Neoplasms ISO RGD:1352533 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:20625127 chronic myeloid leukemia ISO RGD:1352533 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:16999817 withdrawal disorder ISO RGD:1352533 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:20738730 Imported Annotations - OMIM
advanced sleep phase syndrome 3 ISO RGD:1352533 7240710 OMIM
(+)-schisandrin B multiple interactions EXP 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of PER3 mRNA] CTD PMID:31150632 1-naphthyl isothiocyanate increases expression EXP 6480464 1-Naphthylisothiocyanate results in increased expression of PER3 mRNA CTD PMID:30723492 2,2',4,4',5,5'-hexachlorobiphenyl multiple interactions ISO RGD:731847 6480464 [Tetrachlorodibenzodioxin co-treated with 2 more ... CTD PMID:28433925 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:731847 6480464 Tetrachlorodibenzodioxin affects the expression of PER3 mRNA CTD PMID:21570461 , PMID:28922406 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:731847 6480464 [Tetrachlorodibenzodioxin co-treated with 2 more ... CTD PMID:28433925 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of PER3 mRNA CTD PMID:21215274 , PMID:22808131 3,3',4,4',5-pentachlorobiphenyl increases expression EXP 6480464 3 more ... CTD PMID:23196670 , PMID:32119087 3,3',4,4'-tetrachlorobiphenyl multiple interactions ISO RGD:731847 6480464 3 more ... CTD PMID:19467301 3,4-methylenedioxymethamphetamine increases expression ISO RGD:731847 6480464 N-Methyl-3, 4-methylenedioxyamphetamine results in increased expression of PER3 mRNA CTD PMID:26251327 3,4-methylenedioxymethamphetamine increases methylation ISO RGD:731847 6480464 N-Methyl-3, 4-methylenedioxyamphetamine results in increased methylation of PER3 promoter CTD PMID:26251327 3,4-methylenedioxymethamphetamine decreases expression ISO RGD:731847 6480464 N-Methyl-3, 4-methylenedioxyamphetamine results in decreased expression of PER3 mRNA CTD PMID:26251327 4-hydroxyphenyl retinamide decreases expression ISO RGD:731847 6480464 Fenretinide results in decreased expression of PER3 mRNA CTD PMID:28973697 6-propyl-2-thiouracil decreases expression EXP 6480464 Propylthiouracil results in decreased expression of PER3 mRNA CTD PMID:24780913 acrylamide decreases expression EXP 6480464 Acrylamide results in decreased expression of PER3 mRNA CTD PMID:28959563 acrylamide increases expression ISO RGD:731847 6480464 Acrylamide results in increased expression of PER3 mRNA CTD PMID:30807115 aflatoxin B1 increases expression ISO RGD:731847 6480464 Aflatoxin B1 results in increased expression of PER3 mRNA CTD PMID:19770486 aflatoxin B1 increases expression EXP 6480464 Aflatoxin B1 results in increased expression of PER3 mRNA CTD PMID:23630614 , PMID:25378103 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of PER3 mRNA CTD PMID:16483693 amphetamine decreases expression EXP 6480464 Amphetamine results in decreased expression of PER3 mRNA CTD PMID:30779732 antirheumatic drug increases expression ISO RGD:1352533 6480464 Antirheumatic Agents results in increased expression of PER3 mRNA CTD PMID:24449571 benzo[a]pyrene multiple interactions ISO RGD:731847 6480464 [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of PER3 mRNA CTD PMID:27858113 benzo[b]fluoranthene increases expression ISO RGD:731847 6480464 benzo(b)fluoranthene results in increased expression of PER3 mRNA CTD PMID:26377693 benzo[b]fluoranthene multiple interactions ISO RGD:731847 6480464 [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of PER3 mRNA CTD PMID:27858113 bis(2-ethylhexyl) phthalate multiple interactions ISO RGD:731847 6480464 [Tetrachlorodibenzodioxin co-treated with 2 more ... CTD PMID:28433925 bis(2-ethylhexyl) phthalate decreases expression ISO RGD:1352533 6480464 Diethylhexyl Phthalate results in decreased expression of PER3 mRNA CTD PMID:31163220 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of PER3 mRNA CTD PMID:25181051 , PMID:30816183 bisphenol A increases methylation EXP 6480464 bisphenol A results in increased methylation of PER3 gene CTD PMID:28505145 bisphenol A multiple interactions ISO RGD:731847 6480464 [Tetrachlorodibenzodioxin co-treated with 2 more ... CTD PMID:28433925 butanal decreases expression ISO RGD:1352533 6480464 butyraldehyde results in decreased expression of PER3 mRNA CTD PMID:26079696 C60 fullerene increases expression EXP 6480464 fullerene C60 results in increased expression of PER3 mRNA CTD PMID:19167457 carbon nanotube decreases expression ISO RGD:731847 6480464 Nanotubes, Carbon analog results in decreased expression of PER3 mRNA, Nanotubes, Carbon results in decreased expression of PER3 mRNA CTD PMID:25554681 , PMID:25620056 cerium trichloride increases expression ISO RGD:731847 6480464 cerous chloride results in increased expression of PER3 mRNA CTD PMID:23573234 chloroprene increases expression EXP 6480464 Chloroprene results in increased expression of PER3 mRNA CTD PMID:23125180 choline multiple interactions ISO RGD:731847 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of PER3 mRNA CTD PMID:20938992 chrysene multiple interactions ISO RGD:731847 6480464 [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of PER3 mRNA CTD PMID:27858113 cisplatin decreases expression ISO RGD:1352533 6480464 Cisplatin results in decreased expression of PER3 mRNA CTD PMID:27392435 cisplatin multiple interactions ISO RGD:1352533 6480464 [Cisplatin co-treated with jinfukang] results in decreased expression of PER3 mRNA CTD PMID:27392435 cocaine multiple interactions ISO RGD:731847 6480464 Cocaine promotes the reaction [NPAS2 protein binds to PER3 promoter] CTD PMID:23776671 cocaine increases expression ISO RGD:731847 6480464 Cocaine results in increased expression of PER3 mRNA, Cocaine results in increased expression of PER3 protein CTD PMID:15994025 , PMID:23776671 copper atom increases expression EXP 6480464 Copper results in increased expression of PER3 mRNA CTD PMID:30556269 copper(0) increases expression EXP 6480464 Copper results in increased expression of PER3 mRNA CTD PMID:30556269 cyclosporin A decreases expression ISO RGD:1352533 6480464 Cyclosporine results in decreased expression of PER3 mRNA CTD PMID:20106945 dibenz[a,h]anthracene increases expression ISO RGD:731847 6480464 1 more ... CTD PMID:26377693 dibutyl phthalate decreases expression ISO RGD:731847 6480464 Dibutyl Phthalate results in decreased expression of PER3 mRNA CTD PMID:17361019 , PMID:21266533 dichloroacetic acid increases expression ISO RGD:731847 6480464 Dichloroacetic Acid results in increased expression of PER3 mRNA CTD PMID:28962523 dichloromethane increases expression ISO RGD:731847 6480464 Methylene Chloride results in increased expression of PER3 mRNA CTD PMID:28392392 dicrotophos increases expression ISO RGD:1352533 6480464 dicrotophos results in increased expression of PER3 mRNA CTD PMID:28302478 diethyl maleate decreases expression EXP 6480464 diethyl maleate results in decreased expression of PER3 mRNA CTD PMID:21161181 dioxygen multiple interactions ISO RGD:731847 6480464 [NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of PER3 mRNA CTD PMID:30529165 disodium selenite decreases expression ISO RGD:1352533 6480464 Sodium Selenite results in decreased expression of PER3 mRNA CTD PMID:18175754 dorsomorphin multiple interactions ISO RGD:1352533 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 doxorubicin decreases expression ISO RGD:1352533 6480464 Doxorubicin results in decreased expression of PER3 mRNA CTD PMID:29803840 elemental selenium decreases expression ISO RGD:1352533 6480464 Selenium results in decreased expression of PER3 mRNA CTD PMID:19244175 endosulfan decreases expression EXP 6480464 Endosulfan results in decreased expression of PER3 mRNA CTD PMID:29391264 ethanol affects expression ISO RGD:731847 6480464 Ethanol affects the expression of PER3 mRNA CTD PMID:30319688 folic acid multiple interactions ISO RGD:731847 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of PER3 mRNA CTD PMID:20938992 furan increases expression EXP 6480464 furan results in increased expression of PER3 mRNA CTD PMID:25539665 gold atom multiple interactions ISO RGD:731847 6480464 [Gold co-treated with Polyethylene Glycols] results in decreased expression of PER3 mRNA CTD PMID:19695318 gold(0) multiple interactions ISO RGD:731847 6480464 [Gold co-treated with Polyethylene Glycols] results in decreased expression of PER3 mRNA CTD PMID:19695318 isoprenaline decreases expression ISO RGD:731847 6480464 Isoproterenol results in decreased expression of PER3 mRNA CTD PMID:20003209 L-methionine multiple interactions ISO RGD:731847 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of PER3 mRNA CTD PMID:20938992 lead(0) decreases expression ISO RGD:1352533 6480464 Lead results in decreased expression of PER3 mRNA CTD PMID:19921347 lead(2+) decreases expression ISO RGD:1352533 6480464 Lead results in decreased expression of PER3 mRNA CTD PMID:19921347 metacetamol decreases expression ISO RGD:731847 6480464 3-hydroxyacetanilide results in decreased expression of PER3 mRNA CTD PMID:18544908 methotrexate increases expression ISO RGD:1352533 6480464 Methotrexate results in increased expression of PER3 mRNA CTD PMID:24449571 methylmercury chloride decreases expression ISO RGD:1352533 6480464 methylmercuric chloride results in decreased expression of PER3 mRNA CTD PMID:28001369 mono(2-ethylhexyl) phthalate increases expression ISO RGD:731847 6480464 mono-(2-ethylhexyl)phthalate results in increased expression of PER3 mRNA CTD PMID:22401849 N-nitrosodiethylamine multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of PER3 mRNA CTD PMID:20360939 nickel atom decreases expression ISO RGD:1352533 6480464 Nickel results in decreased expression of PER3 mRNA CTD PMID:25583101 ochratoxin A increases expression ISO RGD:1352533 6480464 ochratoxin A results in increased expression of PER3 mRNA CTD PMID:30559759 paracetamol decreases expression ISO RGD:731847 6480464 Acetaminophen results in decreased expression of PER3 mRNA CTD PMID:18544908 paracetamol increases expression ISO RGD:1352533 6480464 Acetaminophen results in increased expression of PER3 mRNA CTD PMID:21420995 pentanal decreases expression ISO RGD:1352533 6480464 pentanal results in decreased expression of PER3 mRNA CTD PMID:26079696 phenethyl caffeate multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of PER3 mRNA CTD PMID:20360939 phenethyl isothiocyanate decreases expression ISO RGD:1352533 6480464 phenethyl isothiocyanate results in decreased expression of PER3 mRNA CTD PMID:26678675 phenobarbital increases expression ISO RGD:1352533 6480464 Phenobarbital results in increased expression of PER3 mRNA CTD PMID:19084549 phenobarbital affects expression ISO RGD:731847 6480464 Phenobarbital affects the expression of PER3 mRNA CTD PMID:23091169 phenylmercury acetate decreases expression ISO RGD:1352533 6480464 Phenylmercuric Acetate results in decreased expression of PER3 mRNA CTD PMID:26272509 phenylmercury acetate multiple interactions ISO RGD:1352533 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PER3 mRNA CTD PMID:27188386 pirinixic acid increases expression ISO RGD:731847 6480464 pirinixic acid results in increased expression of PER3 mRNA CTD PMID:17426115 potassium chromate decreases expression ISO RGD:1352533 6480464 potassium chromate(VI) results in decreased expression of PER3 mRNA CTD PMID:22714537 pregnenolone 16alpha-carbonitrile decreases expression ISO RGD:731847 6480464 Pregnenolone Carbonitrile results in decreased expression of PER3 mRNA CTD PMID:28903501 progesterone decreases expression ISO RGD:1352533 6480464 Progesterone results in decreased expression of PER3 mRNA CTD PMID:21795739 propanal decreases expression ISO RGD:1352533 6480464 propionaldehyde results in decreased expression of PER3 mRNA CTD PMID:26079696 Ritodrine increases expression ISO RGD:731847 6480464 Ritodrine results in increased expression of PER3 mRNA CTD PMID:23370008 rotenone increases expression EXP 6480464 Rotenone results in increased expression of PER3 mRNA CTD PMID:28374803 SB 431542 multiple interactions ISO RGD:1352533 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 Se-methyl-L-selenocysteine increases expression EXP 6480464 selenomethylselenocysteine results in increased expression of PER3 mRNA CTD PMID:19122877 Se-methylselenocysteine increases expression EXP 6480464 selenomethylselenocysteine results in increased expression of PER3 mRNA CTD PMID:19122877 selenium atom decreases expression ISO RGD:1352533 6480464 Selenium results in decreased expression of PER3 mRNA CTD PMID:19244175 silicon dioxide increases expression ISO RGD:1352533 6480464 Silicon Dioxide analog results in increased expression of PER3 mRNA CTD PMID:25895662 silver atom increases expression ISO RGD:731847 6480464 Silver results in increased expression of PER3 mRNA CTD PMID:27131904 silver(0) increases expression ISO RGD:731847 6480464 Silver results in increased expression of PER3 mRNA CTD PMID:27131904 sodium arsenate increases expression ISO RGD:731847 6480464 sodium arsenate results in increased expression of PER3 mRNA CTD PMID:21795629 styrene increases expression ISO RGD:731847 6480464 Styrene results in increased expression of PER3 mRNA CTD PMID:28951217 testosterone decreases expression ISO RGD:731847 6480464 Testosterone results in decreased expression of PER3 mRNA CTD PMID:20403060 tetrachloromethane multiple interactions EXP 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of PER3 mRNA] CTD PMID:31150632 tetrachloromethane decreases expression EXP 6480464 Carbon Tetrachloride results in decreased expression of PER3 mRNA CTD PMID:31150632 tetraphene increases expression ISO RGD:731847 6480464 benz(a)anthracene results in increased expression of PER3 mRNA CTD PMID:26377693 tetraphene multiple interactions ISO RGD:731847 6480464 [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of PER3 mRNA CTD PMID:27858113 thioacetamide increases expression EXP 6480464 Thioacetamide results in increased expression of PER3 mRNA CTD PMID:23411599 titanium dioxide affects expression EXP 6480464 titanium dioxide affects the expression of PER3 mRNA CTD PMID:30012374 trichloroethene increases methylation EXP 6480464 Trichloroethylene results in increased methylation of PER3 gene CTD PMID:27618143 triphenyl phosphate increases expression EXP 6480464 triphenyl phosphate results in increased expression of PER3 mRNA CTD PMID:30589522 troglitazone decreases expression ISO RGD:731847 6480464 troglitazone results in decreased expression of PER3 mRNA CTD PMID:28973697 tunicamycin increases expression ISO RGD:1352533 6480464 Tunicamycin results in increased expression of PER3 mRNA CTD PMID:22378314 urethane decreases expression ISO RGD:1352533 6480464 Urethane results in decreased expression of PER3 mRNA CTD PMID:28818685 valproic acid affects expression ISO RGD:731847 6480464 Valproic Acid affects the expression of PER3 mRNA CTD PMID:17963808 valproic acid multiple interactions ISO RGD:1352533 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PER3 mRNA CTD PMID:27188386 valproic acid decreases expression ISO RGD:1352533 6480464 Valproic Acid results in decreased expression of PER3 mRNA CTD PMID:23179753 more ... vinclozolin increases expression EXP 6480464 vinclozolin results in increased expression of PER3 mRNA CTD PMID:23034163 vitamin E decreases expression ISO RGD:1352533 6480464 Vitamin E results in decreased expression of PER3 mRNA CTD PMID:19244175 vorinostat multiple interactions ISO RGD:1352533 6480464 [NOG protein co-treated with Vorinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PER3 mRNA CTD PMID:27188386 vorinostat decreases expression ISO RGD:1352533 6480464 vorinostat results in decreased expression of PER3 mRNA CTD PMID:27188386 zinc atom decreases expression ISO RGD:1352533 6480464 Zinc deficiency results in decreased expression of PER3 mRNA CTD PMID:18356318 zinc(0) decreases expression ISO RGD:1352533 6480464 Zinc deficiency results in decreased expression of PER3 mRNA CTD PMID:18356318
Biological Process circadian regulation of gene expression IEA InterPro:IPR015524 1600115 GO_REF:0000002 InterPro GO_REF:0000002 circadian regulation of gene expression IBA FB:FBgn0003068 more ... 13792537 PMID:21873635 GO_Central circadian rhythm ISO RGD:731847 1624291 (MGI:MGI:2667759, PMID:12843397) RGD MGI:MGI:2667759 , PMID:12843397 entrainment of circadian clock by photoperiod IBA FB:FBgn0003068 more ... 13792537 PMID:21873635 GO_Central negative regulation of transcription by RNA polymerase II ISO RGD:1352533 1624291 (PMID:26903630) RGD PMID:26903630 negative regulation of transcription by RNA polymerase II IBA FB:FBgn0003068 more ... 13792537 PMID:21873635 GO_Central negative regulation of transcription by RNA polymerase II ISS UniProtKB:P56645 1600115 GO_REF:0000024 UniProt GO_REF:0000024 negative regulation of transcription by RNA polymerase II IEA UniProtKB:P56645 , ensembl:ENSP000004820931600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of transcription by RNA polymerase II IEA UniProtKB:O70361 , ensembl:ENSMUSP000000994931600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of transcription by RNA polymerase II ISO RGD:731847 1624291 (MGI:MGI:1327772, PMID:9989497) RGD MGI:MGI:1327772 , PMID:9989497 protein stabilization ISO RGD:1352533 1624291 (PMID:26903630) RGD PMID:26903630 protein stabilization ISS UniProtKB:P56645 1600115 GO_REF:0000024 UniProt GO_REF:0000024 protein stabilization IEA UniProtKB:P56645 , ensembl:ENSP000004820931600115 GO_REF:0000107 Ensembl GO_REF:0000107 regulation of circadian sleep/wake cycle, sleep ISO RGD:1352533 1624291 (PMID:17346965), (PMID:19716732), (PMID:24439663), (PMID:24577121), (PMID:26903630) RGD PMID:17346965 more ... regulation of circadian sleep/wake cycle, sleep ISS UniProtKB:P56645 1600115 GO_REF:0000024 UniProt GO_REF:0000024 regulation of circadian sleep/wake cycle, sleep ISO RGD:731847 1624291 (MGI:MGI:5300112, PMID:21957163) RGD MGI:MGI:5300112 , PMID:21957163 regulation of circadian sleep/wake cycle, sleep IEA UniProtKB:P56645 , ensembl:ENSP000004820931600115 GO_REF:0000107 Ensembl GO_REF:0000107 regulation of circadian sleep/wake cycle, sleep IEA UniProtKB:O70361 , ensembl:ENSMUSP000000994931600115 GO_REF:0000107 Ensembl GO_REF:0000107 response to light stimulus IBA MGI:MGI:1098283 more ... 13792537 PMID:21873635 GO_Central Cellular Component cytoplasm ISO RGD:1352533 1624291 (PMID:26903630) RGD PMID:26903630 cytoplasm IBA FB:FBgn0003068 more ... 13792537 PMID:21873635 GO_Central cytoplasm ISS UniProtKB:P56645 1600115 GO_REF:0000024 UniProt GO_REF:0000024 cytoplasm IEA UniProtKB:P56645 , ensembl:ENSP000004820931600115 GO_REF:0000107 Ensembl GO_REF:0000107 nucleus ISO RGD:1352533 1624291 (PMID:26903630) RGD PMID:26903630 nucleus IBA FB:FBgn0003068 more ... 13792537 PMID:21873635 GO_Central nucleus ISS UniProtKB:P56645 1600115 GO_REF:0000024 UniProt GO_REF:0000024 nucleus IEA UniProtKB:P56645 , ensembl:ENSP000004820931600115 GO_REF:0000107 Ensembl GO_REF:0000107 Molecular Function kinase binding IEA UniProtKB:O70361 , ensembl:ENSMUSP000000994931600115 GO_REF:0000107 Ensembl GO_REF:0000107 kinase binding ISO RGD:731847 1624291 UniProtKB:P49674 (MGI:MGI:5567915 , PMID:15917222) RGD MGI:MGI:5567915 , PMID:15917222 protein binding ISO RGD:1352533 1624291 UniProtKB:O96017 (PMID:21070773) RGD PMID:21070773 protein binding ISO RGD:731847 1624291 PR:O35973 more ... RGD MGI:MGI:1316572 more ... transcription corepressor binding IBA MGI:MGI:1195265 , PANTHER:PTN000138364 13792537 PMID:21873635 GO_Central transcription factor binding IBA FB:FBgn0003068 more ... 13792537 PMID:21873635 GO_Central transcription regulatory region sequence-specific DNA binding IBA MGI:MGI:1098283 more ... 13792537 PMID:21873635 GO_Central ubiquitin protein ligase binding IEA UniProtKB:O70361 , ensembl:ENSMUSP000000994931600115 GO_REF:0000107 Ensembl GO_REF:0000107 ubiquitin protein ligase binding ISO RGD:731847 1624291 UniProtKB:Q9UKB1 more ... RGD MGI:MGI:5567915 , PMID:15917222
Gene-Chemical Interaction Annotations
