Tnfrsf25 (TNF receptor superfamily member 25) - Rat Genome Database

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Gene: Tnfrsf25 (TNF receptor superfamily member 25) Rattus norvegicus
Analyze
Symbol: Tnfrsf25
Name: TNF receptor superfamily member 25
RGD ID: 1598206
Description: Predicted to be involved in apoptotic process and signal transduction. Predicted to be active in plasma membrane. Orthologous to human TNFRSF25 (TNF receptor superfamily member 25); PARTICIPATES IN cytokine mediated signaling pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC500592; similar to tumor necrosis factor receptor superfamily, member 25; tumor necrosis factor receptor superfamily member 25; tumor necrosis factor receptor superfamily, member 25
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25162,621,669 - 162,626,341 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5162,622,075 - 162,626,341 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5165,324,993 - 165,329,273 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.05167,146,418 - 167,150,819 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.05167,108,623 - 167,113,025 (+)NCBIRnor_WKY
Rnor_6.05169,288,419 - 169,293,137 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5169,288,871 - 169,293,137 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05172,846,849 - 172,851,588 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45169,344,695 - 169,348,961 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera5160,854,219 - 160,858,485 (+)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3'-diindolylmethane  (ISO)
3,4-methylenedioxymethamphetamine  (EXP,ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
acetamide  (EXP)
acetylsalicylic acid  (ISO)
acrylamide  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
amphetamine  (EXP)
aristolochic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (EXP,ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
Brevetoxin B  (ISO)
cadmium atom  (ISO)
capsaicin  (ISO)
carbon nanotube  (ISO)
chloroprene  (EXP)
choline  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
cocaine  (ISO)
copper(II) sulfate  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
D-glucose  (ISO)
diarsenic trioxide  (EXP,ISO)
diazinon  (ISO)
diethylstilbestrol  (ISO)
dimethylarsinic acid  (ISO)
dioscin  (ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
folic acid  (ISO)
fonofos  (ISO)
furan  (EXP)
furosemide  (EXP)
genistein  (ISO)
gentamycin  (EXP)
glucose  (ISO)
hesperidin  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
L-methionine  (ISO)
Licochalcone A  (ISO)
lipopolysaccharide  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
melittin  (ISO)
metformin  (ISO)
methotrexate  (ISO)
methylarsonic acid  (ISO)
methylseleninic acid  (ISO)
microcystin RR  (ISO)
morin  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
nickel sulfate  (ISO)
p-menthan-3-ol  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP)
paraquat  (ISO)
parathion  (ISO)
phenylarsine oxide  (ISO)
potassium chromate  (ISO)
propylparaben  (ISO)
raloxifene  (ISO)
SB 431542  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
sunitinib  (ISO)
terbufos  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
thymoquinone  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
trimellitic anhydride  (ISO)
trimethyltin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
venom  (ISO)
vorinostat  (ISO)
zearalenone  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
plasma membrane  (IBA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:11911831  


Genomics

Comparative Map Data
Tnfrsf25
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25162,621,669 - 162,626,341 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5162,622,075 - 162,626,341 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5165,324,993 - 165,329,273 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.05167,146,418 - 167,150,819 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.05167,108,623 - 167,113,025 (+)NCBIRnor_WKY
Rnor_6.05169,288,419 - 169,293,137 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5169,288,871 - 169,293,137 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05172,846,849 - 172,851,588 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45169,344,695 - 169,348,961 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera5160,854,219 - 160,858,485 (+)NCBICelera
Cytogenetic Map5q36NCBI
TNFRSF25
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3816,460,786 - 6,466,173 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl16,460,786 - 6,466,175 (-)EnsemblGRCh38hg38GRCh38
GRCh3716,520,846 - 6,526,233 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3616,443,798 - 6,448,842 (-)NCBINCBI36Build 36hg18NCBI36
Build 3416,455,481 - 6,460,521NCBI
Celera15,635,659 - 5,640,703 (-)NCBICelera
Cytogenetic Map1p36.31NCBI
HuRef15,668,754 - 5,673,798 (-)NCBIHuRef
CHM1_116,509,749 - 6,514,768 (-)NCBICHM1_1
T2T-CHM13v2.015,986,428 - 5,991,815 (-)NCBIT2T-CHM13v2.0
Tnfrsf25
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394152,199,985 - 152,204,576 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4152,200,391 - 152,204,576 (+)EnsemblGRCm39 Ensembl
GRCm384152,115,528 - 152,120,119 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4152,115,934 - 152,120,119 (+)EnsemblGRCm38mm10GRCm38
MGSCv374151,490,452 - 151,494,220 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364150,959,734 - 150,963,919 (+)NCBIMGSCv36mm8
Celera4154,402,873 - 154,406,641 (+)NCBICelera
Cytogenetic Map4E2NCBI
Tnfrsf25
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554866,122,454 - 6,126,782 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554866,121,906 - 6,127,060 (+)NCBIChiLan1.0ChiLan1.0
TNFRSF25
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.116,475,460 - 6,480,424 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl16,475,498 - 6,480,424 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v015,222,680 - 5,228,211 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
TNFRSF25
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1560,316,473 - 60,321,299 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl560,316,688 - 60,320,897 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha560,326,053 - 60,330,894 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0560,532,149 - 60,536,990 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl560,532,364 - 60,536,345 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1560,531,447 - 60,536,288 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0560,398,216 - 60,403,057 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0560,799,807 - 60,804,648 (-)NCBIUU_Cfam_GSD_1.0
Tnfrsf25
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505830,764,744 - 30,769,036 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049366231,249,979 - 1,254,273 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TNFRSF25
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl667,316,825 - 67,321,442 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1667,316,818 - 67,321,442 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2662,269,346 - 62,274,497 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TNFRSF25
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120125,276,632 - 125,282,090 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20125,277,680 - 125,281,995 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605429,332,359 - 29,337,742 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tnfrsf25
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248185,010,508 - 5,012,453 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Position Markers
RH132108  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25162,626,083 - 162,626,286 (+)MAPPERmRatBN7.2
Rnor_6.05169,292,880 - 169,293,082NCBIRnor6.0
Rnor_5.05172,851,331 - 172,851,533UniSTSRnor5.0
RGSC_v3.45169,348,704 - 169,348,906UniSTSRGSC3.4
Celera5160,858,228 - 160,858,430UniSTS
RH 3.4 Map51138.2UniSTS
Cytogenetic Map5q36UniSTS
RH141643  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25162,621,241 - 162,621,421 (+)MAPPERmRatBN7.2
Rnor_6.05169,288,038 - 169,288,217NCBIRnor6.0
Rnor_5.05172,846,489 - 172,846,668UniSTSRnor5.0
RGSC_v3.45169,343,862 - 169,344,041UniSTSRGSC3.4
Celera5160,853,386 - 160,853,565UniSTS
RH 3.4 Map51140.0UniSTS
Cytogenetic Map5q36UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
1641920Colcs1Colorectal carcinoma susceptibility QTL 12.990.0055intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)5121846814166846814Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5124965598166875058Rat
724525Bp147Blood pressure QTL 1474.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5126424772166875058Rat
1598819Bp292Blood pressure QTL 2924.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5127798274166875058Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5127798274166875058Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5128506074166875058Rat
8694169Bw148Body weight QTL 14850.001body mass (VT:0001259)body weight gain (CMO:0000420)5128506074166875058Rat
634349Bp139Blood pressure QTL 1390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5128924607166875058Rat
738018Anxrr4Anxiety related response QTL 45.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)5130130159166875058Rat
7794791Mcs33Mammary carcinoma susceptibility QTL 331.93mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)5131345754166875058Rat
631505Bp103Blood pressure QTL 1033.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5132717196165560427Rat
631562Apr2Acute phase response QTL 23.7blood murinoglobulin 1 amount (VT:0010597)plasma murinoglobulin 1 level (CMO:0001931)5135927956166875058Rat
61444Strs2Sensitivity to stroke QTL 24.7cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)5135929696166875058Rat
1331721Bp210Blood pressure QTL 2103.413arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)5143069996166846814Rat
1354631Swd2Spike wave discharge measurement QTL 23.640.0002brain electrophysiology trait (VT:0010557)brain total spike-and-wave discharge duration (CMO:0001740)5151113452164465185Rat
631272Lanf1Left ventricular atrial natriuretic factor QTL 112heart left ventricle natriuretic peptide A amount (VT:0010596)heart left ventricle natriuretic peptide A level (CMO:0002165)5151113452166875058Rat
1549904Neuinf1Neuroinflammation QTL 130nervous system integrity trait (VT:0010566)blood T lymphocyte count (CMO:0000110)5154828214166875058Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:33
Count of miRNA genes:30
Interacting mature miRNAs:33
Transcripts:ENSRNOT00000055466
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 4 6 1
Low 3 43 50 38 13 38 6 9 74 33 36 11 6
Below cutoff 3 3 3 2 2 2 4 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000055466   ⟹   ENSRNOP00000052331
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5162,622,075 - 162,626,341 (+)Ensembl
Rnor_6.0 Ensembl5169,288,871 - 169,293,137 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000103279   ⟹   ENSRNOP00000083357
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5162,622,511 - 162,626,341 (+)Ensembl
RefSeq Acc Id: NM_001137644   ⟹   NP_001131116
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25162,622,075 - 162,626,341 (+)NCBI
Rnor_6.05169,288,871 - 169,293,137 (+)NCBI
Rnor_5.05172,846,849 - 172,851,588 (+)NCBI
RGSC_v3.45169,344,695 - 169,348,961 (+)RGD
Celera5160,854,219 - 160,858,485 (+)RGD
Sequence:
RefSeq Acc Id: XM_006239473   ⟹   XP_006239535
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25162,621,669 - 162,626,335 (+)NCBI
Rnor_6.05169,288,419 - 169,293,131 (+)NCBI
Rnor_5.05172,846,849 - 172,851,588 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006239474   ⟹   XP_006239536
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25162,621,669 - 162,626,335 (+)NCBI
Rnor_6.05169,288,419 - 169,293,131 (+)NCBI
Rnor_5.05172,846,849 - 172,851,588 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039110650   ⟹   XP_038966578
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25162,623,161 - 162,626,335 (+)NCBI
RefSeq Acc Id: XM_039110651   ⟹   XP_038966579
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25162,621,669 - 162,625,369 (+)NCBI
RefSeq Acc Id: XM_039110652   ⟹   XP_038966580
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25162,621,669 - 162,625,369 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_001131116   ⟸   NM_001137644
- Peptide Label: precursor
- UniProtKB: D4ADP7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006239535   ⟸   XM_006239473
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006239536   ⟸   XM_006239474
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSRNOP00000052331   ⟸   ENSRNOT00000055466
RefSeq Acc Id: XP_038966579   ⟸   XM_039110651
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038966580   ⟸   XM_039110652
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038966578   ⟸   XM_039110650
- Peptide Label: isoform X3
RefSeq Acc Id: ENSRNOP00000083357   ⟸   ENSRNOT00000103279
Protein Domains
Death   TNFR-Cys

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4ADP7-F1-model_v2 AlphaFold D4ADP7 1-407 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (mRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
Damaging Variants


Assembly: Rnor_6.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
5 169292306 169292307 C T snv LE/Stm (RGD), FXLE18/Stm (2020), LEXF10A/StmMcwi (2020), LEXF4/Stm (2020), LE/Stm (2019), LEXF11/Stm (2020)


Assembly: Rnor_5.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
5 172850757 172850758 C T snv LE/Stm (Illumina) (KNAW), LEC/Tj (KyushuU), LE/Stm (KyushuU), LE/Stm (SOLiD) (KNAW)


Assembly: mRatBN7.2

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
5 162625510 162625511 C T snv FXLE18/Stm (2020), LEXF11/Stm (2020), LEXF10A/StmMcwi (2020), LE/Stm (2019), LEXF4/Stm (2020)


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1598206 AgrOrtholog
BioCyc Gene G2FUF-39021 BioCyc
Ensembl Genes ENSRNOG00000021814 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000052331 ENTREZGENE
  ENSRNOP00000052331.2 UniProtKB/TrEMBL
  ENSRNOP00000083357 ENTREZGENE
  ENSRNOP00000083357.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000055466 ENTREZGENE
  ENSRNOT00000055466.3 UniProtKB/TrEMBL
  ENSRNOT00000103279 ENTREZGENE
  ENSRNOT00000103279.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.533.10 UniProtKB/TrEMBL
InterPro Death UniProtKB/TrEMBL
  DEATH-like UniProtKB/TrEMBL
  TNFR_25 UniProtKB/TrEMBL
  TNFR_Cys_rich_reg UniProtKB/TrEMBL
  TNFRSF25_N UniProtKB/TrEMBL
KEGG Report rno:500592 UniProtKB/TrEMBL
NCBI Gene 500592 ENTREZGENE
PANTHER PTHR47220 UniProtKB/TrEMBL
Pfam Death UniProtKB/TrEMBL
  TNFR_c6 UniProtKB/TrEMBL
PhenoGen Tnfrsf25 PhenoGen
PRINTS TNFACTORR25 UniProtKB/TrEMBL
PROSITE DEATH_DOMAIN UniProtKB/TrEMBL
  TNFR_NGFR_1 UniProtKB/TrEMBL
  TNFR_NGFR_2 UniProtKB/TrEMBL
SMART DEATH UniProtKB/TrEMBL
  TNFR UniProtKB/TrEMBL
Superfamily-SCOP DEATH_like UniProtKB/TrEMBL
UniProt A0A8I5ZZ87_RAT UniProtKB/TrEMBL
  D4ADP7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-07-05 Tnfrsf25  TNF receptor superfamily member 25  Tnfrsf25  tumor necrosis factor receptor superfamily, member 25  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-05 Tnfrsf25  tumor necrosis factor receptor superfamily, member 25  LOC500592  similar to tumor necrosis factor receptor superfamily, member 25  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC500592  similar to tumor necrosis factor receptor superfamily, member 25      Symbol and Name status set to provisional 70820 PROVISIONAL