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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3193
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nppa
Name: natriuretic peptide A
Acc ID: CHEBI:17634
Term: D-glucose
Definition: A glucose with D-configuration.
Chemical ID: MESH:D005947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nppaincreases expressionEXP 6480464CTDGlucose results in increased expression of NPPA mRNA; Glucose results in increased expression of NPPA proteinPMID:24810525 PMID:30144576
Nppamultiple interactionsEXP 6480464CTDcinnamic acid inhibits the reaction [Glucose results in increased expression of NPPA protein]; HMOX1 protein affects the reaction [Propofol inhibits the reaction [Glucose results in increased expression of NPPA mRNA]]; Metformin inhibits the reaction [Glucose results in increased expression of NPPA protein]; NPPA protein inhibits the reaction [SLC5A2 protein results in increased uptake of Glucose]; Propofol inhibits the reaction [Glucose results in increased expression of NPPA mRNA]; STAT3 protein affects the reaction [Propofol inhibits the reaction [Glucose results in increased expression of NPPA mRNA]]PMID:15127950 PMID:24810525 PMID:30144576
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