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Berberine Reduces Neurotoxicity Related to Nonalcoholic Steatohepatitis in Rats.

Authors: Ghareeb, Doaa A  Khalil, Sofia  Hafez, Hani S  Bajorath, Jürgen  Ahmed, Hany E A  Sarhan, Eman  Elwakeel, Eiman  El-Demellawy, Maha A 
Citation: Ghareeb DA, etal., Evid Based Complement Alternat Med. 2015;2015:361847. doi: 10.1155/2015/361847. Epub 2015 Oct 20.
Pubmed: (View Article at PubMed) PMID:26576191
DOI: Full-text: DOI:10.1155/2015/361847

Berberine is a plant alkaloid that has several pharmacological effects such as antioxidant, antilipidemic, and anti-inflammatory effects. Nonalcoholic steatohepatitis (NASH) triggers different aspects of disorders such as impaired endogenous lipid metabolism, hypercholesterolemia, oxidative stress, and neurotoxicity. In this study, we examined the mechanism by which NASH induces neurotoxicity and the protective effect of berberine against both NASH and its associated neurotoxicity. NASH induced rats showed significant impairments in lipid metabolism with increased serum triglycerides, cholesterol, and low-density lipoprotein (LDL). The NASH induced group also demonstrated a significant oxidative stress which is characterized by increased TBARs level and decreased antioxidant capacity such as GSH and SOD levels. Moreover, the NASH induction was associated with inflammation which was demonstrated by increased TNFα and nitric oxide levels. Hyperglycemia and hyperinsulinemia were observed in the NASH induced group. Also, our results showed a significant increase in the expression of the acetylcholine esterase (AChE) and amyloid beta precursor protein (AßPP). These changes were significantly correlated with decreased insulin degrading enzyme (IDE) and beta-amyloid40 (Aß 40) and increased beta-amyloid42 (Aß 42) in the hippocampal region. Daily administration of berberine (50¿mg/kg) for three weeks ameliorated oxidative stress, inflammation, hyperlipidemia, hyperglycemia, hyperinsulinemia, and the observed neurotoxicity.

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RGD ID: 13792804
Created: 2018-09-28
Species: All species
Last Modified: 2018-09-28
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.