IDE (insulin degrading enzyme) - Rat Genome Database

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Gene: IDE (insulin degrading enzyme) Canis lupus familiaris
Analyze
Symbol: IDE
Name: insulin degrading enzyme
RGD ID: 12071043
Description: ENCODES a protein that exhibits amyloid-beta binding (ortholog); ATP binding (ortholog); ATP hydrolysis activity (ortholog); INVOLVED IN amyloid-beta clearance (ortholog); amyloid-beta metabolic process (ortholog); hormone catabolic process (ortholog); ASSOCIATED WITH Alzheimer's disease (ortholog); Cognitive Dysfunction (ortholog); diabetic encephalopathy (ortholog); FOUND IN cell surface (ortholog); cytosolic proteasome complex (ortholog); endosome lumen (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: insulin-degrading enzyme; insulin-degrading enzyme isoform 15a; insulin-degrading protein enzyme 15b
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1286,844,480 - 6,967,713 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl286,844,055 - 6,967,713 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha287,022,845 - 7,145,664 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0287,097,078 - 7,242,543 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl287,098,967 - 7,229,235 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1286,826,499 - 6,949,290 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0286,860,782 - 6,983,875 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0287,025,500 - 7,148,346 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:20875843   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
IDE
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1286,844,480 - 6,967,713 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl286,844,055 - 6,967,713 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha287,022,845 - 7,145,664 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0287,097,078 - 7,242,543 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl287,098,967 - 7,229,235 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1286,826,499 - 6,949,290 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0286,860,782 - 6,983,875 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0287,025,500 - 7,148,346 (-)NCBIUU_Cfam_GSD_1.0
IDE
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381092,451,684 - 92,574,093 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1092,451,684 - 92,574,096 (-)EnsemblGRCh38hg38GRCh38
GRCh371094,211,441 - 94,333,850 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361094,203,580 - 94,323,832 (-)NCBINCBI36Build 36hg18NCBI36
Build 341094,204,018 - 94,323,813NCBI
Celera1087,952,861 - 88,075,347 (-)NCBICelera
Cytogenetic Map10q23.33NCBI
HuRef1087,837,258 - 87,960,004 (-)NCBIHuRef
CHM1_11094,493,176 - 94,615,858 (-)NCBICHM1_1
T2T-CHM13v2.01093,330,970 - 93,453,429 (-)NCBIT2T-CHM13v2.0
Ide
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391937,246,140 - 37,341,664 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1937,246,142 - 37,340,010 (-)EnsemblGRCm39 Ensembl
GRCm381937,268,743 - 37,334,544 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1937,268,743 - 37,337,852 (-)EnsemblGRCm38mm10GRCm38
MGSCv371937,343,231 - 37,409,034 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361937,335,574 - 37,399,688 (-)NCBIMGSCv36mm8
Celera1938,043,942 - 38,138,431 (-)NCBICelera
Cytogenetic Map19C2NCBI
cM Map1932.24NCBI
Ide
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81244,415,495 - 244,516,925 (-)NCBIGRCr8
mRatBN7.21235,002,984 - 235,102,448 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1234,995,351 - 235,102,440 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1243,391,715 - 243,489,902 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01250,321,195 - 250,419,385 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01243,159,390 - 243,257,588 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01255,914,465 - 256,014,168 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1255,914,447 - 256,013,495 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01263,389,549 - 263,489,002 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41241,547,869 - 241,646,052 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11241,737,460 - 241,835,644 (-)NCBI
Celera1232,095,058 - 232,193,208 (-)NCBICelera
Cytogenetic Map1q53NCBI
Ide
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955425847,615 - 926,318 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955425819,461 - 926,440 (+)NCBIChiLan1.0ChiLan1.0
IDE
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28104,487,164 - 104,615,627 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110104,492,478 - 104,617,589 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01089,196,295 - 89,320,223 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11092,714,343 - 92,833,430 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1092,716,540 - 92,833,353 (-)Ensemblpanpan1.1panPan2
Ide
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721340,597,592 - 40,685,962 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366012,230,283 - 2,318,752 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366012,230,477 - 2,318,562 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IDE
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14103,992,039 - 104,106,576 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114103,992,035 - 104,106,571 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214113,505,034 - 113,619,303 (-)NCBISscrofa10.2Sscrofa10.2susScr3
IDE
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1985,722,728 - 85,843,247 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl985,721,886 - 85,843,117 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604846,459,858 - 46,578,672 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ide
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247373,702,985 - 3,835,776 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247373,708,309 - 3,822,390 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in IDE
1147 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10

Sequence


Ensembl Acc Id: ENSCAFT00000011966   ⟹   ENSCAFP00000011097
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl286,844,055 - 6,967,713 (-)Ensembl
Ensembl Acc Id: ENSCAFT00000011973   ⟹   ENSCAFP00000011103
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl286,844,055 - 6,967,713 (-)Ensembl
Ensembl Acc Id: ENSCAFT00000047364   ⟹   ENSCAFP00000038324
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl286,844,055 - 6,868,194 (-)Ensembl
Ensembl Acc Id: ENSCAFT00000088748   ⟹   ENSCAFP00000048302
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl286,844,055 - 6,967,713 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845053517   ⟹   ENSCAFP00845042049
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl287,098,967 - 7,229,235 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845053558   ⟹   ENSCAFP00845042084
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl287,098,967 - 7,229,235 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845053621   ⟹   ENSCAFP00845042133
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl287,098,967 - 7,229,235 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845053677   ⟹   ENSCAFP00845042175
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl287,098,967 - 7,228,762 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845053688   ⟹   ENSCAFP00845042184
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl287,098,981 - 7,229,235 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845053720   ⟹   ENSCAFP00845042213
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl287,098,981 - 7,228,833 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845053723   ⟹   ENSCAFP00845042215
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl287,101,071 - 7,229,235 (-)Ensembl
RefSeq Acc Id: NM_001314100   ⟹   NP_001301029
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1286,844,480 - 6,967,713 (-)NCBI
Dog10K_Boxer_Tasha287,022,845 - 7,145,664 (-)NCBI
ROS_Cfam_1.0287,101,193 - 7,228,713 (-)NCBI
UMICH_Zoey_3.1286,826,499 - 6,949,290 (-)NCBI
UNSW_CanFamBas_1.0286,860,782 - 6,983,875 (-)NCBI
UU_Cfam_GSD_1.0287,025,500 - 7,148,346 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038439631   ⟹   XP_038295559
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0287,097,078 - 7,228,791 (-)NCBI
RefSeq Acc Id: XM_038439632   ⟹   XP_038295560
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0287,097,078 - 7,242,543 (-)NCBI
RefSeq Acc Id: XM_038439633   ⟹   XP_038295561
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0287,097,078 - 7,181,965 (-)NCBI
RefSeq Acc Id: XM_038439634   ⟹   XP_038295562
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0287,097,078 - 7,182,019 (-)NCBI
RefSeq Acc Id: XM_038439635   ⟹   XP_038295563
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0287,097,078 - 7,181,789 (-)NCBI
RefSeq Acc Id: XM_038439636   ⟹   XP_038295564
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0287,097,078 - 7,157,902 (-)NCBI
RefSeq Acc Id: NP_001301029   ⟸   NM_001314100
- UniProtKB: A0A8I3Q3Z2 (UniProtKB/TrEMBL),   A0A8P0N9V4 (UniProtKB/TrEMBL),   U5XYR4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000048302   ⟸   ENSCAFT00000088748
Ensembl Acc Id: ENSCAFP00000011097   ⟸   ENSCAFT00000011966
Ensembl Acc Id: ENSCAFP00000011103   ⟸   ENSCAFT00000011973
Ensembl Acc Id: ENSCAFP00000038324   ⟸   ENSCAFT00000047364
RefSeq Acc Id: XP_038295560   ⟸   XM_038439632
- Peptide Label: isoform X2
- UniProtKB: A0A8C0NG52 (UniProtKB/TrEMBL),   A0A8C0N953 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038295559   ⟸   XM_038439631
- Peptide Label: isoform X1
- UniProtKB: U5XY96 (UniProtKB/TrEMBL),   A0A8I3Q3Z2 (UniProtKB/TrEMBL),   A0A8P0N9V4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038295562   ⟸   XM_038439634
- Peptide Label: isoform X4
- UniProtKB: A0A8C0N953 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038295561   ⟸   XM_038439633
- Peptide Label: isoform X3
- UniProtKB: A0A8C0N953 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038295563   ⟸   XM_038439635
- Peptide Label: isoform X4
- UniProtKB: A0A8C0N953 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038295564   ⟸   XM_038439636
- Peptide Label: isoform X5
Ensembl Acc Id: ENSCAFP00845042133   ⟸   ENSCAFT00845053621
Ensembl Acc Id: ENSCAFP00845042213   ⟸   ENSCAFT00845053720
Ensembl Acc Id: ENSCAFP00845042215   ⟸   ENSCAFT00845053723
Ensembl Acc Id: ENSCAFP00845042084   ⟸   ENSCAFT00845053558
Ensembl Acc Id: ENSCAFP00845042049   ⟸   ENSCAFT00845053517
Ensembl Acc Id: ENSCAFP00845042175   ⟸   ENSCAFT00845053677
Ensembl Acc Id: ENSCAFP00845042184   ⟸   ENSCAFT00845053688
Protein Domains
Coenzyme PQQ synthesis protein F-like C-terminal   Peptidase M16 C-terminal   Peptidase M16 middle/third   Peptidase M16 N-terminal

Promoters
RGD ID:13688260
Promoter ID:EPDNEW_C6330
Type:initiation region
Name:IDE_1
Description:Canis lupus familiaris insulin degrading enzyme , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1286,967,778 - 6,967,838EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000007467 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030014260 UniProtKB/TrEMBL
  ENSCAFG00845030157 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000011966.5 UniProtKB/TrEMBL
  ENSCAFT00000011973.6 UniProtKB/TrEMBL
  ENSCAFT00000047364.4 UniProtKB/TrEMBL
  ENSCAFT00000088748.2 UniProtKB/TrEMBL
  ENSCAFT00000097399.1 UniProtKB/TrEMBL
  ENSCAFT00000103761.1 UniProtKB/TrEMBL
  ENSCAFT00000104982.1 UniProtKB/TrEMBL
  ENSCAFT00030026420.1 UniProtKB/TrEMBL
  ENSCAFT00030026740.1 UniProtKB/TrEMBL
  ENSCAFT00030026780.1 UniProtKB/TrEMBL
  ENSCAFT00030026955.1 UniProtKB/TrEMBL
  ENSCAFT00845053517 ENTREZGENE
  ENSCAFT00845053517.1 UniProtKB/TrEMBL
  ENSCAFT00845053558.1 UniProtKB/TrEMBL
  ENSCAFT00845053621.1 UniProtKB/TrEMBL
  ENSCAFT00845053677.1 UniProtKB/TrEMBL
  ENSCAFT00845053688 ENTREZGENE
  ENSCAFT00845053688.1 UniProtKB/TrEMBL
  ENSCAFT00845053720.1 UniProtKB/TrEMBL
  ENSCAFT00845053723 ENTREZGENE
  ENSCAFT00845053723.1 UniProtKB/TrEMBL
Gene3D-CATH Metalloenzyme, LuxS/M16 peptidase-like UniProtKB/TrEMBL
InterPro Metalloenz_LuxS/M16 UniProtKB/TrEMBL
  Pept_M16_N UniProtKB/TrEMBL
  Pept_M16_Zn_BS UniProtKB/TrEMBL
  Peptidase_M16 UniProtKB/TrEMBL
  Peptidase_M16_C UniProtKB/TrEMBL
  Peptidase_M16_M UniProtKB/TrEMBL
  PqqF-like_C_4 UniProtKB/TrEMBL
KEGG Report cfa:477768 UniProtKB/TrEMBL
NCBI Gene IDE ENTREZGENE
PANTHER INSULIN-DEGRADING ENZYME-RELATED UniProtKB/TrEMBL
  NARDILYSIN UniProtKB/TrEMBL
Pfam Peptidase_M16 UniProtKB/TrEMBL
  Peptidase_M16_C UniProtKB/TrEMBL
  Peptidase_M16_M UniProtKB/TrEMBL
  PqqF-like_C_4 UniProtKB/TrEMBL
PROSITE INSULINASE UniProtKB/TrEMBL
Superfamily-SCOP SSF63411 UniProtKB/TrEMBL
UniProt A0A8C0N953 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0NBV4_CANLF UniProtKB/TrEMBL
  A0A8C0NG52 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0NNU9_CANLF UniProtKB/TrEMBL
  A0A8I3Q3Z2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3Q625_CANLF UniProtKB/TrEMBL
  A0A8I3QBV9_CANLF UniProtKB/TrEMBL
  A0A8I3QES4_CANLF UniProtKB/TrEMBL
  A0A8I3QMN5_CANLF UniProtKB/TrEMBL
  A0A8I3QXD3_CANLF UniProtKB/TrEMBL
  A0A8I3S7J2_CANLF UniProtKB/TrEMBL
  A0A8P0N9V4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0PLW1_CANLF UniProtKB/TrEMBL
  A0A8P0TNB8_CANLF UniProtKB/TrEMBL
  A0A8P0TPJ6_CANLF UniProtKB/TrEMBL
  U5XY96 ENTREZGENE, UniProtKB/TrEMBL
  U5XYR4 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A0A8P0SSX5 UniProtKB/TrEMBL
  A0A8P0T157 UniProtKB/TrEMBL
VGNC ID VGNC:41863 ENTREZGENE