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Gene: App (amyloid beta precursor protein) Rattus norvegicus
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Symbol: App
Name: amyloid beta precursor protein
Description: Exhibits growth factor receptor binding activity and peptidase activator activity. Involved in several processes, including cellular response to metal ion; cellular response to nerve growth factor stimulus; and cellular response to organonitrogen compound. Localizes to several cellular components, including the axon; cytoplasm; and extracellular space. Used to study Alzheimer's disease. Biomarker of Alzheimer's disease; diabetic encephalopathy; hypertension; iron deficiency anemia; and middle cerebral artery infarction. Human ortholog(s) of this gene implicated in APP-related cerebral amyloid angiopathy; Alzheimer's disease; Alzheimer's disease 1; cognitive disorder; and visual epilepsy. Orthologous to human APP (amyloid beta precursor protein); PARTICIPATES IN glypican signaling pathway; Alzheimer's disease pathway; INTERACTS WITH (+)-catechin; (S)-naringenin; (S)-nicotine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: Abeta; ABPP; AG; alzheimer disease amyloid A4 protein homolog; amyloid A4; amyloid beta (A4) precursor protein; amyloid beta A4 protein; amyloidogenic glycoprotein
Orthologs:
Homo sapiens (human) : APP (amyloid beta precursor protein)  HGNC  Alliance
Mus musculus (house mouse) : App (amyloid beta (A4) precursor protein)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : App (amyloid beta precursor protein)
Pan paniscus (bonobo/pygmy chimpanzee) : APP (amyloid beta precursor protein)
Canis lupus familiaris (dog) : APP (amyloid beta precursor protein)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : App (amyloid beta precursor protein)
Sus scrofa (pig) : APP (amyloid beta precursor protein)
more info ...
Allele / Splice: Appem1Sage  
Genetic Models: SD-Appem1Sage
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01124,425,013 - 24,641,872 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01128,048,897 - 28,265,250 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41124,457,855 - 24,693,851 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11124,457,854 - 24,693,851 (-)NCBI
Celera1123,853,696 - 24,069,048 (-)NCBICelera
Cytogenetic Map11q11NCBI
RH 3.4 Map1194.7RGD
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)