App (amyloid beta precursor protein) - Rat Genome Database

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Gene: App (amyloid beta precursor protein) Rattus norvegicus
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Symbol: App
Name: amyloid beta precursor protein
RGD ID: 2139
Description: Enables growth factor receptor binding activity and peptidase activator activity. Involved in several processes, including cellular response to cAMP; cellular response to norepinephrine stimulus; and defense response to other organism. Located in several cellular components, including astrocyte projection; axon; and cell surface. Is active in neuronal dense core vesicle. Used to study Alzheimer's disease. Biomarker of Alzheimer's disease; diabetic encephalopathy; hypertension; iron deficiency anemia; and middle cerebral artery infarction. Human ortholog(s) of this gene implicated in APP-related cerebral amyloid angiopathy; Alzheimer's disease; Alzheimer's disease 1; cognitive disorder; and traumatic brain injury. Orthologous to human APP (amyloid beta precursor protein); PARTICIPATES IN glypican signaling pathway; Alzheimer's disease pathway; INTERACTS WITH (+)-catechin; (S)-naringenin; (S)-nicotine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Abeta; ABPP; AG; alzheimer disease amyloid A4 protein homolog; amyloid A4; amyloid beta (A4) precursor protein; amyloid beta A4 protein; amyloidogenic glycoprotein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Appem1Sage
Genetic Models: SD-Appem1Sage
Candidate Gene For: Edcs1
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81137,506,207 - 37,724,351 (-)NCBIGRCr8
mRatBN7.21124,019,774 - 24,236,584 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1124,019,778 - 24,236,561 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1132,713,957 - 32,929,750 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01125,414,338 - 25,630,128 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01124,603,106 - 24,818,898 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01124,425,013 - 24,641,872 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1124,425,005 - 24,641,858 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01128,048,897 - 28,265,250 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41124,457,855 - 24,693,851 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11124,457,854 - 24,693,851 (-)NCBI
Celera1123,853,696 - 24,069,048 (-)NCBICelera
RH 3.4 Map1194.7RGD
Cytogenetic Map11q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
alcohol dependence  (IEP)
alcohol use disorder  (IEP)
alcoholic hepatitis  (IEP)
Alzheimer's disease  (IDA,IEP,ISO,ISS)
Alzheimer's disease 1  (ISO)
Alzheimer's Disease, Early-Onset, with Cerebral Amyloid Angiopathy  (ISO)
amnestic disorder  (ISO)
Amyloid Angiopathy  (ISO)
Amyloid Neuropathies  (ISO)
Amyloid Plaques  (ISO)
amyloidosis  (ISO)
Animal Disease Models  (ISO)
anxiety disorder  (ISO)
APP-related cerebral amyloid angiopathy  (ISO)
Blast Injuries  (IEP)
brain disease  (ISO)
Brain Injuries  (ISO)
cardiomyopathy  (ISO)
cerebral amyloid angiopathy  (ISO)
Chronic Cerebral Hypoperfusion  (IEP)
cognitive disorder  (ISO)
Cognitive Dysfunction  (IEP,ISO)
CST3-related cerebral amyloid angiopathy  (ISO)
dementia  (ISO)
diabetic encephalopathy  (IEP)
Experimental Autoimmune Neuritis  (IDA)
Experimental Liver Cirrhosis  (ISO)
Experimental Seizures  (ISO)
Eye Manifestations  (ISO)
familial focal epilepsy with variable foci  (ISO)
fragile X syndrome  (ISO)
genetic disease  (ISO)
Gliosis  (ISO)
HIV Encephalitis  (ISO)
hypertension  (IEP)
iron deficiency anemia  (IEP)
learning disability  (ISO)
Memory Disorders  (ISO)
middle cerebral artery infarction  (IEP)
Multi-Infarct Dementia  (ISO)
Necrosis  (ISO)
Nerve Degeneration  (ISO)
neurodegenerative disease  (ISO)
Neurodevelopmental Disorders  (ISO)
Neurogenic Inflammation  (ISO)
obesity  (ISO)
Paralysis  (ISO)
periodontitis  (ISO)
Postoperative Cognitive Dysfunction  (IEP,ISO)
Premature Aging  (ISO)
Presenile and Senile Dementia  (ISO)
spinal cord disease  (ISO)
Splenomegaly  (ISO)
traumatic brain injury  (IEP,ISO)
vascular dementia  (ISO)
Weight Gain  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
(24S)-24-hydroxycholesterol  (ISO)
(25R)-cholest-5-ene-3beta,26-diol  (ISO)
(5Z,8Z,11Z,13E)-15-HETE  (ISO)
(R)-carnitine  (ISO)
(R,R,R)-alpha-tocopherol  (ISO)
(S)-naringenin  (EXP)
(S)-nicotine  (EXP,ISO)
(Z)-ligustilide  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (EXP,ISO)
1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,2'-Methylenebis(4-methyl-6-tert-butylphenol)  (ISO)
2,2,2-tetramine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-dihydroxybenzoic acid  (ISO)
2,4,4'-trichlorobiphenyl  (ISO)
2,4-dinitrophenol  (ISO)
2,5-dihydroxybenzoic acid  (ISO)
2,6-dinitrotoluene  (EXP)
2-deoxy-D-glucose  (ISO)
2-ethoxyethanol  (EXP)
2-hydroxypropanoic acid  (ISO)
2-methoxyethanol  (EXP)
26-hydroxycholesterol  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP,ISO)
3,3',5-triiodo-L-thyronine  (EXP,ISO)
3,4-dihydroxybenzoic acid  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-methyladenine  (ISO)
3-nitrophenol  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
4,7-diphenyl-1,10-phenanthroline  (ISO)
4-hydroxynon-2-enal  (ISO)
4-phenylbutyric acid  (EXP)
5,6,7,8-tetrahydrobiopterin  (ISO)
5-(beta-D-galactosyloxy)-L-lysine  (ISO)
5-azacytidine  (ISO)
5-chloro-7-iodoquinolin-8-ol  (ISO)
5-methoxypsoralen  (ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
7alpha-hydroxycholesterol  (EXP)
8-epi-prostaglandin F2alpha  (ISO)
9-cis-retinoic acid  (ISO)
acetamide  (EXP)
acetyl-CoA  (ISO)
acetylcholine  (EXP,ISO)
acetylsalicylic acid  (ISO)
aconitic acid  (ISO)
acrolein  (EXP,ISO)
adenine  (ISO)
ADP  (ISO)
aflatoxin B1  (EXP,ISO)
agmatine  (ISO)
AICA ribonucleotide  (ISO)
aldehydo-D-glucose  (ISO)
aldicarb  (ISO)
alendronic acid  (ISO)
all-trans-retinoic acid  (EXP,ISO)
all-trans-retinol  (EXP)
alpha-D-galactose  (ISO)
alpha-hexachlorocyclohexane  (EXP)
alpha-mangostin  (ISO)
alpha-pinene  (ISO)
aluminium atom  (EXP,ISO)
aluminium hydroxide  (ISO)
aluminium sulfate (anhydrous)  (ISO)
aluminium(0)  (EXP,ISO)
ambenonium chloride  (EXP)
aminoguanidine  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
anandamide  (EXP,ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
arachidonic acid  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenic trichloride  (ISO)
arsenous acid  (ISO)
astaxanthin  (ISO)
atorvastatin calcium  (ISO)
ATP  (ISO)
atrazine  (EXP)
Azoxymethane  (ISO)
azure B  (ISO)
baicalein  (EXP)
benzene  (ISO)
benzo[a]pyrene  (ISO)
berberine  (EXP)
Bergenin  (EXP)
beta-D-fructofuranose 1,6-bisphosphate  (ISO)
beta-lapachone  (ISO)
bethanechol  (EXP)
bexarotene  (EXP)
bilobalide  (ISO)
biotin  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisdemethoxycurcumin  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (EXP)
bisphenol F  (EXP,ISO)
buspirone  (EXP)
buten-2-one  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
calcium atom  (EXP,ISO)
calcium(0)  (EXP,ISO)
calycosin  (EXP)
cannabidiol  (ISO)
carbachol  (ISO)
carbon nanotube  (ISO)
carnosine  (ISO)
carvedilol  (ISO)
celecoxib  (ISO)
chloropicrin  (ISO)
chloroquine  (EXP)
chlorpyrifos  (ISO)
cholesterol  (EXP,ISO)
choline  (ISO)
cilostazol  (ISO)
cis-caffeic acid  (ISO)
citric acid  (ISO)
clofibrate  (EXP)
clofibric acid  (EXP)
clozapine  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (ISO)
cocaine  (EXP,ISO)
coenzyme Q10  (EXP)
Congo Red  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (EXP,ISO)
cordycepin  (EXP)
corosolic acid  (ISO)
coumestrol  (ISO)
creatine  (ISO)
crocidolite asbestos  (ISO)
CTP  (ISO)
curcumin  (EXP,ISO)
cyclosporin A  (ISO)
cyprodinil  (ISO)
D-fructofuranose 1,6-bisphosphate  (ISO)
D-gluconic acid  (ISO)
D-glucopyranose 6-phosphate  (ISO)
D-glucose  (ISO)
D-penicillamine  (ISO)
DAPT  (ISO)
DDE  (ISO)
DDT  (ISO)
decabromodiphenyl ether  (EXP,ISO)
demethoxycurcumin  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (EXP)
dextran sulfate  (ISO)
Di-n-octyl phthalate  (ISO)
diarsenic trioxide  (ISO)
dichlorvos  (EXP,ISO)
Didymin  (ISO)
dieldrin  (EXP)
diethyldithiocarbamic acid  (ISO)
dihydrogen  (ISO)
dimercaprol  (ISO)
dimethylarsinic acid  (ISO)
diminazene diaceturate  (ISO)
diprotium  (ISO)
disodium selenite  (ISO)
disulfiram  (ISO)
diuron  (EXP)
dizocilpine maleate  (EXP)
donepezil hydrochloride  (EXP,ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
DPCPX  (EXP)
duvoglustat  (ISO)
edaravone  (EXP)
elemental selenium  (ISO)
ellagic acid  (EXP)
enzalutamide  (ISO)
ethanol  (ISO)
ethosuximide  (EXP)
Ethyl maltol  (ISO)
ethylenediaminetetraacetic acid  (ISO)
farrerol  (EXP)
fenofibrate  (ISO)
ferroheme b  (ISO)
finasteride  (EXP)
fipronil  (EXP)
fisetin  (ISO)
flurbiprofen  (EXP,ISO)
flutamide  (EXP)
folic acid  (ISO)
folpet  (ISO)
fonofos  (ISO)
fructose 6-phosphate  (ISO)
fulvestrant  (EXP,ISO)
fumaric acid  (ISO)
fumonisin B1  (ISO)
furan  (EXP)
galactose  (ISO)
galanthamine  (ISO)
galanthamine Trifluoroacetic acid  (ISO)
gallic acid  (ISO)
gamma-tocopherol  (EXP)
Garcinone C  (ISO)
Garcinone D  (ISO)
genistein  (ISO)
gentamycin  (EXP)
ginkgolide B  (ISO)
Ginkgolide C  (ISO)
ginsenoside Rd  (EXP)
ginsenoside Rg1  (EXP)
ginsenoside Rg2  (EXP)
glucose  (ISO)
glutathione  (EXP,ISO)
glyceraldehyde 3-phosphate  (ISO)
glycerol 1-phosphate  (ISO)
glycine  (ISO)
glycine betaine  (ISO)
glycitin  (EXP)
glyphosate  (ISO)
Goe 6976  (ISO)
GTP  (ISO)
GW 501516  (ISO)
heme b  (ISO)
heparin  (ISO)
heroin  (ISO)
hexaconazole  (ISO)
hexadecanoic acid  (ISO)
homocysteine  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
ibuprofen  (EXP,ISO)
icariin  (EXP)
idarubicin  (ISO)
IMP  (ISO)
indole-3-methanol  (EXP)
indometacin  (EXP,ISO)
inosine  (ISO)
inulin  (ISO)
iron atom  (ISO)
iron(0)  (ISO)
iron(2+) sulfate (anhydrous)  (EXP)
isoflurane  (EXP,ISO)
isoniazide  (ISO)
ivermectin  (ISO)
kaempferol  (EXP)
kaempferol 3-O-beta-D-glucoside  (ISO)
ketamine  (ISO)
keto-D-fructose 1,6-bisphosphate  (ISO)
kojic acid  (ISO)
KT 5720  (ISO)
KT 5823  (ISO)
kynurenine  (ISO)
L-arginine  (ISO)
L-ascorbic acid  (EXP,ISO)
L-cysteine  (ISO)
L-erythro-7,8-dihydrobiopterin  (ISO)
L-glutamic acid  (ISO)
L-glutamine  (ISO)
L-histidine  (ISO)
L-isoleucine  (ISO)
L-lysine  (ISO)
L-methionine  (ISO)
L-serine  (EXP)
L-tryptophan  (ISO)
lactacystin  (ISO)
lead diacetate  (EXP,ISO)
lead tetraacetate  (ISO)
lead(0)  (EXP,ISO)
linoleic acid  (ISO)
lipopolysaccharide  (EXP,ISO)
lithium atom  (EXP,ISO)
lithium chloride  (ISO)
lithium hydride  (EXP,ISO)
lovastatin  (EXP,ISO)
LY294002  (EXP,ISO)
malic acid  (ISO)
malonaldehyde  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
Mecamylamine  (ISO)
melatonin  (EXP,ISO)
meloxicam  (ISO)
memantine  (EXP)
mepanipyrim  (ISO)
mercury atom  (ISO)
mercury dichloride  (ISO)
mercury(0)  (ISO)
methamphetamine  (EXP,ISO)
methapyrilene  (EXP)
methidathion  (ISO)
methotrexate  (ISO)
methoxychlor  (EXP)
methyllycaconitine  (EXP,ISO)
Methysticin  (ISO)
minocycline  (EXP,ISO)
miquelianin  (ISO)
mitomycin C  (ISO)
monensin A  (ISO)
morin  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-acetyl-beta-D-glucosamine  (ISO)
N-acetyl-D-glucosamine  (ISO)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
neoechinulin A  (ISO)
nickel atom  (ISO)
nicotine  (EXP,ISO)
nimodipine  (EXP)
nitric oxide  (ISO)
nitroprusside  (ISO)
notoginsenoside R1  (EXP,ISO)
O-propanoyl-L-carnitine  (ISO)
ochratoxin A  (ISO)
okadaic acid  (ISO)
olanzapine  (EXP)
oleic acid  (ISO)
orlistat  (ISO)
ornithine  (ISO)
orphenadrine  (EXP)
oxaloacetic acid  (ISO)
ozone  (ISO)
p-anisidine  (ISO)
p-menthan-3-ol  (ISO)
palmitoleic acid  (ISO)
paracetamol  (ISO)
paraquat  (EXP,ISO)
parathion  (ISO)
paroxetine  (ISO)
PCB138  (ISO)
pentetrazol  (EXP)
pentobarbital  (EXP)
perfluorobutanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
permethrin  (EXP)
Pf-06840003  (ISO)
phenobarbital  (EXP)
PhIP  (ISO)
phlorizin  (ISO)
phorbol 12,13-dibutanoate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosphatidylcholine  (ISO)
phosphoenolpyruvate  (ISO)
physostigmine  (EXP)
pifithrin-alpha hydrobromide  (EXP)
pioglitazone  (ISO)
piperidine  (ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP,ISO)
poly(I:C)  (EXP)
poly(vinylpyrrolidone)  (ISO)
potassium atom  (EXP)
potassium bromate  (ISO)
pravastatin  (ISO)
pregabalin  (ISO)
pregnenolone  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP)
proanthocyanidin  (EXP)
probucol  (EXP)
progesterone  (ISO)
propiconazole  (EXP)
prostaglandin D2  (ISO)
prostaglandin E2  (EXP,ISO)
prucalopride  (ISO)
pyrimethanil  (ISO)
pyrogallol  (ISO)
pyrrolidine dithiocarbamate  (ISO)
quercetin  (ISO)
quetiapine fumarate  (EXP)
quinine  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
reactive nitrogen species  (ISO)
reactive oxygen species  (EXP,ISO)
resveratrol  (EXP,ISO)
rimonabant  (ISO)
rotenone  (ISO)
rottlerin  (EXP)
ruthenium red  (EXP)
S-adenosyl-L-homocysteine  (ISO)
S-adenosyl-L-methioninate  (ISO)
S-adenosyl-L-methionine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP)
salicylates  (EXP)
sapropterin  (ISO)
sarin  (ISO)
SB 203580  (ISO)
SB 415286  (ISO)
SB 431542  (ISO)
SCH772984  (EXP)
scopolamine  (ISO)
scutellarin  (EXP)
selenium atom  (ISO)
selenomethionine  (EXP)
serotonin  (ISO)
sevoflurane  (EXP,ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (EXP,ISO)
sirolimus  (ISO)
sirtinol  (ISO)
sodium arsenite  (ISO)
sodium azide  (EXP,ISO)
sodium dichromate  (EXP)
sodium nitrite  (ISO)
staurosporine  (ISO)
streptozocin  (EXP,ISO)
succinic acid  (ISO)
sulfur dioxide  (EXP)
sulindac  (ISO)
sulindac sulfide  (EXP,ISO)
superoxide  (ISO)
T-2 toxin  (EXP)
tadalafil  (ISO)
tamoxifen  (EXP,ISO)
tauroursodeoxycholic acid  (EXP,ISO)
terbufos  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP,ISO)
tetracosapentaenoic acid  (ISO)
tetrahydrocurcumin  (ISO)
tetrathiomolybdate(2-)  (ISO)
tetrodotoxin  (ISO)
thapsigargin  (EXP)
thiethylperazine  (ISO)
thioacetamide  (EXP)
thiourea  (ISO)
thymoquinone  (EXP)
thyroxine  (ISO)
titanium dioxide  (ISO)
tocopherol  (EXP)
tolfenamic acid  (ISO)
tolonium chloride  (ISO)
toluene  (EXP)
trans-caffeic acid  (ISO)
trenbolone  (EXP)
triadimefon  (EXP)
trichlorfon  (EXP,ISO)
trilostane  (EXP)
trimellitic anhydride  (ISO)
triolein  (EXP)
triphenyl phosphate  (EXP,ISO)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (ISO)
tubocurarine  (ISO)
tunicamycin  (ISO)
tyrosine  (ISO)
uracil  (ISO)
uranium atom  (ISO)
urethane  (ISO)
ursolic acid  (ISO)
valdecoxib  (EXP)
valine  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vitamin E  (EXP,ISO)
vitexin  (ISO)
WIN 55212-2  (ISO)
wortmannin  (EXP)
Y-27632  (EXP,ISO)
zebularine  (ISO)
zinc atom  (EXP,ISO)
zinc sulfate  (EXP)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenylate cyclase-activating G protein-coupled receptor signaling pathway  (ISO)
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway  (ISO)
adult locomotory behavior  (ISO,ISS)
amyloid fibril formation  (IEA,ISO)
antibacterial humoral response  (IDA)
antifungal humoral response  (IDA)
antimicrobial humoral immune response mediated by antimicrobial peptide  (IDA,ISO)
apoptotic process  (IEA)
associative learning  (ISO)
astrocyte activation  (IEA,ISO)
astrocyte activation involved in immune response  (IEA,ISO)
axo-dendritic transport  (ISO,ISS)
axon midline choice point recognition  (ISO,ISS)
axonogenesis  (IBA,ISO,ISS)
calcium ion transport  (IDA)
calcium-mediated signaling  (ISO)
cell adhesion  (IEA)
cellular response to amyloid-beta  (IEA,ISO)
cellular response to cAMP  (IEP)
cellular response to copper ion  (IEP)
cellular response to manganese ion  (IEP)
cellular response to nerve growth factor stimulus  (IEP)
cellular response to norepinephrine stimulus  (IMP)
central nervous system development  (IBA)
central nervous system neuron differentiation  (ISO)
chemical synaptic transmission  (ISO)
cholesterol metabolic process  (ISO)
cognition  (ISO,ISS)
collateral sprouting in absence of injury  (ISO,ISS)
cytosolic mRNA polyadenylation  (ISO)
defense response to Gram-negative bacterium  (IDA)
defense response to Gram-positive bacterium  (IDA)
dendrite development  (ISO,ISS)
endocytosis  (IEA,ISO,ISS)
extracellular matrix organization  (ISO,ISS)
forebrain development  (ISO)
G protein-coupled receptor signaling pathway  (ISO)
G2/M transition of mitotic cell cycle  (ISO)
gene expression  (ISO)
hippocampal neuron apoptotic process  (IDA)
innate immune response  (IDA,ISO)
intracellular copper ion homeostasis  (ISO,ISS)
ionotropic glutamate receptor signaling pathway  (ISO,ISS)
learning  (IEA,ISO)
learning or memory  (IEA,IEP,ISO)
locomotory behavior  (ISO,ISS)
low-density lipoprotein particle mediated signaling  (ISO)
mating behavior  (ISO,ISS)
memory  (ISO)
microglia development  (IEA,ISO)
microglial cell activation  (IEA,ISO)
mitotic cell cycle  (ISO)
modulation of excitatory postsynaptic potential  (IEA,ISO)
negative regulation of blood circulation  (ISO)
negative regulation of canonical Wnt signaling pathway  (ISO)
negative regulation of cell population proliferation  (IEA,ISO)
negative regulation of gene expression  (IEA,ISO)
negative regulation of long-term synaptic potentiation  (IEA,ISO)
negative regulation of miRNA transcription  (ISO)
negative regulation of neuron differentiation  (ISO)
negative regulation of presynapse assembly  (ISO)
negative regulation of protein localization to nucleus  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
neuromuscular process controlling balance  (ISO)
neuron apoptotic process  (ISO)
neuron cellular homeostasis  (ISO)
neuron differentiation  (ISO)
neuron projection development  (ISO,ISS)
neuron projection maintenance  (IEA,ISO)
neuron remodeling  (ISO,ISS)
Notch signaling pathway  (IEA)
phospholipase D-activating G protein-coupled receptor signaling pathway  (ISO)
positive regulation of amyloid fibril formation  (IEA,ISO)
positive regulation of amyloid precursor protein catabolic process  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of calcium-mediated signaling  (IEA,ISO)
positive regulation of cAMP/PKA signal transduction  (ISO)
positive regulation of chemokine production  (IEA,ISO)
positive regulation of endothelin production  (ISO)
positive regulation of ERK1 and ERK2 cascade  (IDA,IEA,IGI,ISO)
positive regulation of excitatory postsynaptic potential  (ISO)
positive regulation of extrinsic apoptotic signaling pathway  (ISO)
positive regulation of G protein-coupled receptor internalization  (ISO)
positive regulation of G protein-coupled receptor signaling pathway  (ISO)
positive regulation of G2/M transition of mitotic cell cycle  (ISO)
positive regulation of gene expression  (IEA,ISO)
positive regulation of gene expression, epigenetic  (ISO)
positive regulation of glycolytic process  (IEA,ISO)
positive regulation of inflammatory response  (IEA,ISO)
positive regulation of interleukin-1 beta production  (IEA,ISO)
positive regulation of interleukin-6 production  (IEA,ISO)
positive regulation of JNK cascade  (IEA,ISO)
positive regulation of long-term synaptic potentiation  (IEA,ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of membrane protein ectodomain proteolysis  (ISO)
positive regulation of mitotic cell cycle  (ISO,ISS)
positive regulation of monocyte chemotaxis  (ISO)
positive regulation of neuron apoptotic process  (ISO)
positive regulation of neuron differentiation  (ISO)
positive regulation of nitric oxide biosynthetic process  (ISO)
positive regulation of non-canonical NF-kappaB signal transduction  (IEA,ISO)
positive regulation of protein import  (ISO)
positive regulation of protein metabolic process  (IDA,IEA,ISO)
positive regulation of response to endoplasmic reticulum stress  (ISO)
positive regulation of superoxide anion generation  (ISO)
positive regulation of T cell migration  (IEA,ISO)
positive regulation of Toll signaling pathway  (ISO)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
positive regulation of tumor necrosis factor production  (IEA,ISO)
positive regulation of type II interferon production  (ISO)
protein homooligomerization  (ISO)
protein phosphorylation  (ISO)
protein tetramerization  (ISO)
protein trimerization  (ISO)
regulation of amyloid fibril formation  (ISO)
regulation of amyloid-beta clearance  (ISO)
regulation of calcium ion transmembrane transport via high voltage-gated calcium channel  (ISO)
regulation of dendritic spine maintenance  (ISO)
regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway  (ISO)
regulation of epidermal growth factor-activated receptor activity  (ISO)
regulation of gene expression  (IEA,ISO)
regulation of long-term neuronal synaptic plasticity  (IEA,ISO)
regulation of multicellular organism growth  (ISO,ISS)
regulation of neuron apoptotic process  (IEP)
regulation of neurotransmitter uptake  (ISO)
regulation of presynapse assembly  (IEA,ISO)
regulation of response to calcium ion  (IGI)
regulation of spontaneous synaptic transmission  (IEA,ISO)
regulation of synapse structure or activity  (ISO,ISS)
regulation of toll-like receptor signaling pathway  (ISO)
regulation of transcription by RNA polymerase II  (ISO)
regulation of translation  (ISO,ISS)
response to auditory stimulus  (ISO)
response to ethanol  (IEP)
response to insulin-like growth factor stimulus  (IEP)
response to interleukin-1  (IDA)
response to lead ion  (IEP)
response to oxidative stress  (ISO)
response to yeast  (IDA)
smooth endoplasmic reticulum calcium ion homeostasis  (ISO)
suckling behavior  (ISO)
swimming behavior  (IEP)
synapse organization  (IEA,ISO)
synaptic assembly at neuromuscular junction  (ISO)
visual learning  (ISO,ISS)

Cellular Component
amyloid-beta complex  (IEA,ISO)
apical part of cell  (ISO)
astrocyte projection  (IDA)
axon  (IDA,ISO,ISS)
cell body  (ISO)
cell projection  (IEA)
cell surface  (IBA,IDA,IEA,ISO)
cell-cell junction  (ISO)
ciliary rootlet  (ISO)
clathrin-coated pit  (IEA)
COPII-coated ER to Golgi transport vesicle  (ISO)
cytoplasm  (IDA,IEA,ISO,ISS)
cytoplasmic vesicle  (IEA,ISO)
dendrite  (IEA,ISO)
dendrite membrane  (ISO)
dendritic shaft  (IEA,ISO)
dendritic spine  (IEA,ISO)
early endosome  (IBA,IEA,ISO,ISS)
early endosome membrane  (IEA,ISO)
endomembrane system  (IEA)
endoplasmic reticulum  (IEA,ISO)
endosome  (IEA,ISO)
endosome to plasma membrane transport vesicle  (ISO)
external side of plasma membrane  (ISO)
extracellular region  (IEA)
extracellular space  (IDA,IEA,ISO)
Golgi apparatus  (IBA,IEA,ISO,ISS)
Golgi-associated vesicle  (IEA,ISO,ISS)
growth cone  (IDA,IEA)
growth cone filopodium  (IDA)
growth cone lamellipodium  (IDA)
high-density lipoprotein particle  (ISO)
intermediate-density lipoprotein particle  (ISO)
intracellular vesicle  (ISO)
lipoprotein particle  (ISO)
low-density lipoprotein particle  (ISO)
lysosome  (ISO)
main axon  (IDA)
membrane  (IEA,ISO,ISS)
membrane raft  (IBA,IEA,ISO)
mitochondrion  (ISO)
neuromuscular junction  (ISO)
neuron projection  (ISO)
neuronal dense core vesicle  (IDA)
nuclear envelope lumen  (IEA,ISO)
nucleus  (IEA,ISO)
perikaryon  (IEA)
perinuclear region of cytoplasm  (IEA,ISO)
plasma membrane  (IBA,IEA,ISO)
postsynapse  (ISO)
presynapse  (ISO)
presynaptic active zone  (ISO)
protein-containing complex  (ISO)
receptor complex  (IEA,ISO)
recycling endosome  (ISO,ISS)
smooth endoplasmic reticulum  (IEA)
spindle midzone  (ISO)
synapse  (IEA,ISO)
synaptic membrane  (ISO)
synaptic vesicle  (IDA,ISO)
terminal bouton  (HDA)
very-low-density lipoprotein particle  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
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Additional References at PubMed
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PMID:8207383   PMID:8224912   PMID:8624099   PMID:8887653   PMID:8996834   PMID:9085254   PMID:9211985   PMID:9228033   PMID:9390996   PMID:9461064   PMID:9535056   PMID:9685356  
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PMID:14523099   PMID:14622134   PMID:14983046   PMID:15009636   PMID:15090053   PMID:15190117   PMID:15208260   PMID:15385965   PMID:15447675   PMID:15457210   PMID:15537891   PMID:15561424  
PMID:15623526   PMID:15673661   PMID:15689559   PMID:15718043   PMID:15745965   PMID:15886206   PMID:15944124   PMID:15955598   PMID:15987691   PMID:16018997   PMID:16025111   PMID:16077187  
PMID:16153690   PMID:16162853   PMID:16183991   PMID:16193067   PMID:16196193   PMID:16227578   PMID:16259359   PMID:16286452   PMID:16301330   PMID:16314516   PMID:16478525   PMID:16492752  
PMID:16502470   PMID:16636059   PMID:16714296   PMID:16721824   PMID:16734669   PMID:17012232   PMID:17116874   PMID:17157827   PMID:17251419   PMID:17255335   PMID:17308309   PMID:17402971  
PMID:17460216   PMID:17468104   PMID:17556541   PMID:17920016   PMID:17929129   PMID:17937488   PMID:18007179   PMID:18059284   PMID:18077683   PMID:18089558   PMID:18216187   PMID:18234671  
PMID:18263584   PMID:18275940   PMID:18278038   PMID:18353773   PMID:18463498   PMID:18483195   PMID:18499799   PMID:18509662   PMID:18574238   PMID:18585048   PMID:18602473   PMID:18602971  
PMID:18648507   PMID:18694930   PMID:18723082   PMID:18728191   PMID:18759972   PMID:18761056   PMID:18800168   PMID:18805418   PMID:18922798   PMID:18940800   PMID:19057576   PMID:19105196  
PMID:19118188   PMID:19123057   PMID:19164281   PMID:19199708   PMID:19228461   PMID:19264960   PMID:19294646   PMID:19304802   PMID:19340611   PMID:19393223   PMID:19406747   PMID:19458258  
PMID:19515914   PMID:19542631   PMID:19549187   PMID:19549834   PMID:19587288   PMID:19660551   PMID:19686245   PMID:19706468   PMID:19706519   PMID:19726636   PMID:19754881   PMID:19808651  
PMID:19829160   PMID:19841277   PMID:19849849   PMID:19879263   PMID:19927172   PMID:19935655   PMID:19966784   PMID:20005821   PMID:20032460   PMID:20033317   PMID:20037574   PMID:20037584  
PMID:20043977   PMID:20045398   PMID:20127811   PMID:20133839   PMID:20141570   PMID:20145246   PMID:20164328   PMID:20212142   PMID:20333303   PMID:20346152   PMID:20403092   PMID:20427278  
PMID:20445063   PMID:20511235   PMID:20543465   PMID:20568471   PMID:20573181   PMID:20575418   PMID:20594620   PMID:20711450   PMID:20818335   PMID:20829454   PMID:20972601   PMID:20974225  
PMID:20974842   PMID:21036142   PMID:21047784   PMID:21085580   PMID:21113149   PMID:21126803   PMID:21179577   PMID:21187975   PMID:21205198   PMID:21289173   PMID:21297982   PMID:21300137  
PMID:21320494   PMID:21454701   PMID:21457712   PMID:21482827   PMID:21523435   PMID:21527912   PMID:21640074   PMID:21751079   PMID:21803450   PMID:21825135   PMID:21832049   PMID:21843605  
PMID:21852239   PMID:21857966   PMID:21883149   PMID:21903584   PMID:21915767   PMID:21949245   PMID:21989385   PMID:22036569   PMID:22086926   PMID:22138302   PMID:22139836   PMID:22163051  
PMID:22177709   PMID:22179788   PMID:22198949   PMID:22200570   PMID:22209725   PMID:22267734   PMID:22383525   PMID:22406537   PMID:22429478   PMID:22434822   PMID:22500019   PMID:22528492  
PMID:22584060   PMID:22635104   PMID:22666389   PMID:22754299   PMID:22847417   PMID:22854022   PMID:22871113   PMID:22874667   PMID:22905234   PMID:22910909   PMID:22944668   PMID:23020770  
PMID:23041348   PMID:23103738   PMID:23106396   PMID:23149553   PMID:23150673   PMID:23152628   PMID:23164821   PMID:23353684   PMID:23368879   PMID:23374097   PMID:23376485   PMID:23382219  
PMID:23386614   PMID:23416305   PMID:23469123   PMID:23516302   PMID:23520555   PMID:23523687   PMID:23525105   PMID:23531501   PMID:23551356   PMID:23599427   PMID:23603391   PMID:23640054  
PMID:23687299   PMID:23691241   PMID:23793062   PMID:23815291   PMID:23825109   PMID:23888782   PMID:23907009   PMID:23907583   PMID:23921129   PMID:23931995   PMID:24012003   PMID:24052308  
PMID:24065130   PMID:24114864   PMID:24291464   PMID:24298149   PMID:24462250   PMID:24499793   PMID:24508800   PMID:24531160   PMID:24595404   PMID:24599958   PMID:24720730   PMID:24827165  
PMID:25015123   PMID:25052558   PMID:25152461   PMID:25288670   PMID:25390368   PMID:25438880   PMID:25536033   PMID:25543257   PMID:25551598   PMID:25592972   PMID:25620700   PMID:25686087  
PMID:25707991   PMID:25732184   PMID:25742317   PMID:25783987   PMID:25799420   PMID:25938662   PMID:26005850   PMID:26006083   PMID:26024517   PMID:26200696   PMID:26202512   PMID:26325471  
PMID:26401782   PMID:26402095   PMID:26426258   PMID:26510576   PMID:26522221   PMID:26552445   PMID:26743041   PMID:26921470   PMID:27028062   PMID:27064279   PMID:27241555   PMID:27366738  
PMID:27428544   PMID:27460145   PMID:27699791   PMID:27853422   PMID:28008308   PMID:28121396   PMID:28164773   PMID:28219245   PMID:28259979   PMID:28282805   PMID:28302722   PMID:28374012  
PMID:28377502   PMID:28447730   PMID:28650319   PMID:28669260   PMID:28855300   PMID:28877993   PMID:29061364   PMID:29176823   PMID:29263141   PMID:29274751   PMID:29305263   PMID:29371969  
PMID:29436599   PMID:29466733   PMID:29518356   PMID:29572166   PMID:29572520   PMID:29624118   PMID:29624358   PMID:29990310   PMID:30158114   PMID:30989630   PMID:31084925   PMID:31432127  
PMID:32265300   PMID:32382574   PMID:32385113   PMID:32420373   PMID:32686865   PMID:32881772   PMID:34288242   PMID:34647720   PMID:34656177   PMID:34789895   PMID:34818135   PMID:34944019  
PMID:35061720   PMID:36155778   PMID:37179386   PMID:37256589   PMID:38527407   PMID:39159732  


Genomics

Comparative Map Data
App
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81137,506,207 - 37,724,351 (-)NCBIGRCr8
mRatBN7.21124,019,774 - 24,236,584 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1124,019,778 - 24,236,561 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1132,713,957 - 32,929,750 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01125,414,338 - 25,630,128 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01124,603,106 - 24,818,898 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01124,425,013 - 24,641,872 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1124,425,005 - 24,641,858 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01128,048,897 - 28,265,250 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41124,457,855 - 24,693,851 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11124,457,854 - 24,693,851 (-)NCBI
Celera1123,853,696 - 24,069,048 (-)NCBICelera
RH 3.4 Map1194.7RGD
Cytogenetic Map11q11NCBI
APP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382125,880,550 - 26,171,128 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2125,880,535 - 26,171,128 (-)EnsemblGRCh38hg38GRCh38
GRCh372127,252,861 - 27,543,446 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362126,174,732 - 26,465,003 (-)NCBINCBI36Build 36hg18NCBI36
Build 342126,174,732 - 26,465,003NCBI
Celera2112,436,275 - 12,726,567 (-)NCBICelera
Cytogenetic Map21q21.3NCBI
HuRef2112,656,350 - 12,947,965 (-)NCBIHuRef
CHM1_12126,813,502 - 27,104,969 (-)NCBICHM1_1
T2T-CHM13v2.02124,238,622 - 24,529,258 (-)NCBIT2T-CHM13v2.0
App
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391684,751,236 - 84,972,187 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1684,746,573 - 84,970,654 (-)EnsemblGRCm39 Ensembl
GRCm381684,952,666 - 85,175,255 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1684,949,685 - 85,173,766 (-)EnsemblGRCm38mm10GRCm38
MGSCv371684,954,688 - 85,173,948 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361684,837,873 - 85,057,149 (-)NCBIMGSCv36mm8
Celera1685,161,866 - 85,382,753 (-)NCBICelera
Cytogenetic Map16C3.3NCBI
cM Map1646.92NCBI
App
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540725,722,849 - 25,974,268 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540725,725,259 - 25,973,582 (-)NCBIChiLan1.0ChiLan1.0
APP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22222,074,135 - 22,358,605 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12116,933,539 - 17,218,837 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02112,324,455 - 12,608,594 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12125,683,236 - 25,995,262 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2125,684,355 - 25,995,072 (-)Ensemblpanpan1.1panPan2
APP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13121,351,207 - 21,614,466 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3121,351,207 - 21,614,337 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3121,345,590 - 21,608,332 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03121,405,966 - 21,669,000 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3121,405,966 - 21,668,874 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13121,422,808 - 21,685,736 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03121,425,054 - 21,689,657 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03121,899,466 - 22,164,885 (-)NCBIUU_Cfam_GSD_1.0
App
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440497121,893,758 - 22,131,543 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366401,550,167 - 1,787,286 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366401,549,977 - 1,787,436 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
APP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13189,435,094 - 189,716,056 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113189,434,854 - 189,716,120 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213199,290,846 - 199,568,764 (-)NCBISscrofa10.2Sscrofa10.2susScr3
APP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1266,037,224 - 66,320,860 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl266,037,261 - 66,321,306 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660718,700,007 - 8,984,223 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
App
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474513,902,577 - 14,159,372 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474513,904,912 - 14,159,374 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in App
1389 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:588
Count of miRNA genes:251
Interacting mature miRNAs:289
Transcripts:ENSRNOT00000044081, ENSRNOT00000048854
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)11169446234Rat
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
1598842Glom10Glomerulus QTL 103.4kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)11135331169Rat
8694376Bw156Body weight QTL 1562.250.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
10755497Bp388Blood pressure QTL 3882.76arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)111945620576331918Rat
724517Uae18Urinary albumin excretion QTL 183.7urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)111647204744285911Rat
2290451Scl58Serum cholesterol level QTL 583.48blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)111283104625121472Rat
10058952Gmadr6Adrenal mass QTL 62.290.0072adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)112295940367959403Rat
1600394Edcs1Endometrial carcinoma susceptibility QTL12.90.04uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)111897620824697116Rat
1558659Tescar1Testicular tumor resistance QTL 13.9testis integrity trait (VT:0010572)percentage of study population developing testis tumors during a period of time (CMO:0001261)11104193166113562Rat
9589032Epfw10Epididymal fat weight QTL 109.290.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)112328045668280456Rat
9590313Scort20Serum corticosterone level QTL 206.510.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)112328045668280456Rat
8694424Bw162Body weight QTL 1623.80.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
1641927Alcrsp10Alcohol response QTL 10alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)11843667453436674Rat

Markers in Region
D11Got14  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81137,583,362 - 37,583,486 (+)Marker Load Pipeline
mRatBN7.21124,096,935 - 24,097,059 (+)MAPPERmRatBN7.2
Rnor_6.01124,502,166 - 24,502,289NCBIRnor6.0
Rnor_5.01128,126,051 - 28,126,174UniSTSRnor5.0
RGSC_v3.41124,534,122 - 24,534,245UniSTSRGSC3.4
RGSC_v3.41124,534,121 - 24,534,245RGDRGSC3.4
RGSC_v3.11124,534,122 - 24,534,245RGD
Celera1123,929,938 - 23,930,048UniSTS
RH 3.4 Map11115.5RGD
RH 3.4 Map11115.5UniSTS
RH 2.0 Map11568.7RGD
Cytogenetic Map11q11UniSTS
BE108355  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21124,133,377 - 24,133,555 (+)MAPPERmRatBN7.2
Rnor_6.01124,539,021 - 24,539,198NCBIRnor6.0
Rnor_5.01128,162,738 - 28,162,915UniSTSRnor5.0
RGSC_v3.41124,590,587 - 24,590,764UniSTSRGSC3.4
Celera1123,966,316 - 23,966,493UniSTS
RH 3.4 Map11103.7UniSTS
Cytogenetic Map11q11UniSTS
RH94865  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21124,236,274 - 24,236,452 (+)MAPPERmRatBN7.2
Rnor_6.01124,641,553 - 24,641,730NCBIRnor6.0
Rnor_5.01128,264,953 - 28,265,130UniSTSRnor5.0
RGSC_v3.41124,693,697 - 24,693,874UniSTSRGSC3.4
Celera1124,068,894 - 24,069,071UniSTS
RH 3.4 Map1194.7UniSTS
Cytogenetic Map11q11UniSTS
BF388494  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21124,030,592 - 24,030,809 (+)MAPPERmRatBN7.2
Rnor_6.01124,435,832 - 24,436,048NCBIRnor6.0
Rnor_5.01128,059,716 - 28,059,932UniSTSRnor5.0
RGSC_v3.41124,467,785 - 24,468,001UniSTSRGSC3.4
Celera1123,863,626 - 23,863,842UniSTS
RH 3.4 Map11106.3UniSTS
Cytogenetic Map11q11UniSTS
BF389056  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21124,108,880 - 24,109,123 (+)MAPPERmRatBN7.2
Rnor_6.01124,514,262 - 24,514,504NCBIRnor6.0
Rnor_5.01128,138,061 - 28,138,303UniSTSRnor5.0
RGSC_v3.41124,565,915 - 24,566,157UniSTSRGSC3.4
Celera1123,941,822 - 23,942,064UniSTS
RH 3.4 Map11110.5UniSTS
Cytogenetic Map11q11UniSTS
BF403704  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21124,136,753 - 24,136,932 (+)MAPPERmRatBN7.2
Rnor_6.01124,542,397 - 24,542,575NCBIRnor6.0
Rnor_5.01128,166,114 - 28,166,292UniSTSRnor5.0
RGSC_v3.41124,593,963 - 24,594,141UniSTSRGSC3.4
Celera1123,969,692 - 23,969,870UniSTS
RH 3.4 Map1197.3UniSTS
Cytogenetic Map11q11UniSTS
RH139209  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21124,020,079 - 24,020,312 (+)MAPPERmRatBN7.2
Rnor_6.01124,425,319 - 24,425,551NCBIRnor6.0
Rnor_5.01128,049,203 - 28,049,435UniSTSRnor5.0
RGSC_v3.41124,457,272 - 24,457,504UniSTSRGSC3.4
Celera1123,853,113 - 23,853,345UniSTS
RH 3.4 Map11113.8UniSTS
Cytogenetic Map11q11UniSTS
GDB:185158  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21124,020,092 - 24,020,374 (+)MAPPERmRatBN7.2
Rnor_6.01124,425,332 - 24,425,613NCBIRnor6.0
Rnor_5.01128,049,216 - 28,049,497UniSTSRnor5.0
RGSC_v3.41124,457,285 - 24,457,566UniSTSRGSC3.4
Celera1123,853,126 - 23,853,407UniSTS
Cytogenetic Map11q11UniSTS
GDB:185159  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21124,020,354 - 24,020,680 (+)MAPPERmRatBN7.2
Rnor_6.01124,425,594 - 24,425,919NCBIRnor6.0
Rnor_5.01128,049,478 - 28,049,803UniSTSRnor5.0
RGSC_v3.41124,457,547 - 24,457,872UniSTSRGSC3.4
Celera1123,853,388 - 23,853,713UniSTS
Cytogenetic Map11q11UniSTS
APP  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21124,020,022 - 24,020,731 (+)MAPPERmRatBN7.2
Rnor_6.01124,425,262 - 24,425,970NCBIRnor6.0
Rnor_5.01128,049,146 - 28,049,854UniSTSRnor5.0
RGSC_v3.41124,457,215 - 24,457,923UniSTSRGSC3.4
Celera1123,853,056 - 23,853,764UniSTS
Cytogenetic Map11q11UniSTS


Genetic Models
This gene App is modified in the following models/strains:
SD-Appem1Sage    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_019288 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006248008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006248009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006248010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006248011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006248012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063270722 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC110471 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF513015 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY011335 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC062082 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473989 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CS448150 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CS448172 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212168 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214246 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221425 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222596 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L11926 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X14066 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000044081   ⟹   ENSRNOP00000040243
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1124,019,778 - 24,236,530 (-)Ensembl
Rnor_6.0 Ensembl1124,425,813 - 24,641,820 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000048854   ⟹   ENSRNOP00000041613
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1124,019,778 - 24,236,530 (-)Ensembl
Rnor_6.0 Ensembl1124,425,005 - 24,641,858 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000104573   ⟹   ENSRNOP00000078198
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1124,019,781 - 24,236,561 (-)Ensembl
RefSeq Acc Id: NM_019288   ⟹   NP_062161
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81137,507,096 - 37,722,838 (-)NCBI
mRatBN7.21124,020,663 - 24,236,429 (-)NCBI
Rnor_6.01124,425,902 - 24,641,707 (-)NCBI
Rnor_5.01128,048,897 - 28,265,250 (-)NCBI
RGSC_v3.41124,457,855 - 24,693,851 (-)RGD
Celera1123,853,696 - 24,069,048 (-)RGD
Sequence:
RefSeq Acc Id: XM_006248008   ⟹   XP_006248070
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81137,506,207 - 37,723,027 (-)NCBI
mRatBN7.21124,019,774 - 24,236,583 (-)NCBI
Rnor_6.01124,425,013 - 24,641,872 (-)NCBI
Rnor_5.01128,048,897 - 28,265,250 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006248009   ⟹   XP_006248071
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81137,506,207 - 37,723,027 (-)NCBI
mRatBN7.21124,019,774 - 24,236,583 (-)NCBI
Rnor_6.01124,425,202 - 24,641,840 (-)NCBI
Rnor_5.01128,048,897 - 28,265,250 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006248010   ⟹   XP_006248072
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81137,506,207 - 37,723,023 (-)NCBI
mRatBN7.21124,019,774 - 24,236,583 (-)NCBI
Rnor_6.01124,425,013 - 24,641,872 (-)NCBI
Rnor_5.01128,048,897 - 28,265,250 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006248011   ⟹   XP_006248073
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81137,506,207 - 37,724,351 (-)NCBI
mRatBN7.21124,019,774 - 24,236,564 (-)NCBI
Rnor_6.01124,425,013 - 24,641,871 (-)NCBI
Rnor_5.01128,048,897 - 28,265,250 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006248012   ⟹   XP_006248074
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81137,506,207 - 37,723,023 (-)NCBI
mRatBN7.21124,019,774 - 24,236,584 (-)NCBI
Rnor_6.01124,425,013 - 24,641,871 (-)NCBI
Rnor_5.01128,048,897 - 28,265,250 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063270722   ⟹   XP_063126792
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81137,522,163 - 37,723,023 (-)NCBI
RefSeq Acc Id: NP_062161   ⟸   NM_019288
- Peptide Label: precursor
- UniProtKB: Q547B7 (UniProtKB/Swiss-Prot),   P08592 (UniProtKB/Swiss-Prot),   A6JL62 (UniProtKB/TrEMBL),   A0A8L2QLQ8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006248073   ⟸   XM_006248011
- Peptide Label: isoform X4
- UniProtKB: A6JL61 (UniProtKB/TrEMBL),   A0A8L2QLQ8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006248072   ⟸   XM_006248010
- Peptide Label: isoform X3
- UniProtKB: Q6P6Q5 (UniProtKB/TrEMBL),   A0A8L2QLQ8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006248071   ⟸   XM_006248009
- Peptide Label: isoform X2
- UniProtKB: A0A0H2UHW9 (UniProtKB/TrEMBL),   A0A8L2QLQ8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006248070   ⟸   XM_006248008
- Peptide Label: isoform X1
- UniProtKB: A0A8I5Y8G9 (UniProtKB/TrEMBL),   A0A8L2QLQ8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006248074   ⟸   XM_006248012
- Peptide Label: isoform X5
- UniProtKB: A0A8L2QLQ8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000041613   ⟸   ENSRNOT00000048854
Ensembl Acc Id: ENSRNOP00000040243   ⟸   ENSRNOT00000044081
Ensembl Acc Id: ENSRNOP00000078198   ⟸   ENSRNOT00000104573
RefSeq Acc Id: XP_063126792   ⟸   XM_063270722
- Peptide Label: isoform X6
Protein Domains
BPTI/Kunitz inhibitor   E1   E2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P08592-F1-model_v2 AlphaFold P08592 1-770 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698015
Promoter ID:EPDNEW_R8540
Type:multiple initiation site
Name:App_1
Description:amyloid beta precursor protein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01124,641,839 - 24,641,899EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2139 AgrOrtholog
BioCyc Gene G2FUF-22080 BioCyc
Ensembl Genes ENSRNOG00000006997 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000044081 ENTREZGENE
  ENSRNOT00000048854 ENTREZGENE
  ENSRNOT00000104573 ENTREZGENE
  ENSRNOT00000164631 ENTREZGENE
Gene3D-CATH 1.20.120.770 UniProtKB/Swiss-Prot
  2.30.29.30 UniProtKB/Swiss-Prot
  3.30.1490.140 UniProtKB/Swiss-Prot
  3.90.570.10 UniProtKB/Swiss-Prot
  4.10.410.10 UniProtKB/Swiss-Prot
  6.10.250.1670 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:5599880 IMAGE-MGC_LOAD
InterPro Amyloid_Cu-bd_sf UniProtKB/Swiss-Prot
  Amyloid_glyco UniProtKB/Swiss-Prot
  Amyloid_glyco_Abeta UniProtKB/Swiss-Prot
  Amyloid_glyco_Cu-bd UniProtKB/Swiss-Prot
  Amyloid_glyco_E2_domain UniProtKB/Swiss-Prot
  Amyloid_glyco_extra UniProtKB/Swiss-Prot
  Amyloid_glyco_heparin-bd UniProtKB/Swiss-Prot
  Amyloid_glyco_heparin-bd_sf UniProtKB/Swiss-Prot
  Amyloid_glyco_intracell_CS UniProtKB/Swiss-Prot
  APP_amyloid_C UniProtKB/Swiss-Prot
  APP_CUBD_CS UniProtKB/Swiss-Prot
  E2_sf UniProtKB/Swiss-Prot
  Kunitz_BPTI UniProtKB/Swiss-Prot
  Kunitz_BPTI_sf UniProtKB/Swiss-Prot
  PH-like_dom_sf UniProtKB/Swiss-Prot
  Prtase_inh_Kunz-CS UniProtKB/Swiss-Prot
KEGG Report rno:54226 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72270 IMAGE-MGC_LOAD
NCBI Gene 54226 ENTREZGENE
PANTHER PTHR23103 UniProtKB/Swiss-Prot
  PTHR23103:SF7 UniProtKB/Swiss-Prot
Pfam APP_amyloid UniProtKB/Swiss-Prot
  APP_Cu_bd UniProtKB/Swiss-Prot
  APP_E2 UniProtKB/Swiss-Prot
  APP_N UniProtKB/Swiss-Prot
  Beta-APP UniProtKB/Swiss-Prot
  Kunitz_BPTI UniProtKB/Swiss-Prot
PharmGKB APP RGD
PhenoGen App PhenoGen
PRINTS AMYLOIDA4 UniProtKB/Swiss-Prot
  BASICPTASE UniProtKB/Swiss-Prot
  BETAAMYLOID UniProtKB/Swiss-Prot
PROSITE APP_CUBD UniProtKB/Swiss-Prot
  APP_E1 UniProtKB/Swiss-Prot
  APP_E2 UniProtKB/Swiss-Prot
  APP_INTRA UniProtKB/Swiss-Prot
  BPTI_KUNITZ_1 UniProtKB/Swiss-Prot
  BPTI_KUNITZ_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000006997 RatGTEx
SMART A4_EXTRA UniProtKB/Swiss-Prot
  SM00131 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF109843 UniProtKB/Swiss-Prot
  SSF56491 UniProtKB/Swiss-Prot
  SSF57362 UniProtKB/Swiss-Prot
  SSF89811 UniProtKB/Swiss-Prot
UniProt A0A0H2UHW9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5Y8G9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2QLQ8 ENTREZGENE, UniProtKB/TrEMBL
  A4_RAT UniProtKB/Swiss-Prot
  A6JL61 ENTREZGENE, UniProtKB/TrEMBL
  A6JL62 ENTREZGENE, UniProtKB/TrEMBL
  P08592 ENTREZGENE
  Q547B7 ENTREZGENE
  Q6LEE8_RAT UniProtKB/TrEMBL
  Q6P6Q5 ENTREZGENE, UniProtKB/TrEMBL
  Q99NY6_RAT UniProtKB/TrEMBL
UniProt Secondary Q547B7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-20 App  amyloid beta precursor protein  App  amyloid beta (A4) precursor protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 App  Amyloid beta (A4) precursor protein      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease abnormalities of the human homolog may contribute to the pathogenesis of Alzheimers disease 634664
gene_process may induce neuronal apoptosis 634664
gene_process induces calpain protease activity 634664
gene_process activates voltage dependent calcium channels 634664