App (amyloid beta precursor protein) - Rat Genome Database

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Gene: App (amyloid beta precursor protein) Rattus norvegicus
Symbol: App
Name: amyloid beta precursor protein
RGD ID: 2139
Description: Enables growth factor receptor binding activity; ion binding activity; and peptidase activator activity. Involved in several processes, including cellular response to metal ion; cellular response to organonitrogen compound; and defense response to other organism. Located in several cellular components, including astrocyte projection; axon; and cell surface. Is active in neuronal dense core vesicle. Used to study Alzheimer's disease. Biomarker of Alzheimer's disease; diabetic encephalopathy; hypertension; iron deficiency anemia; and middle cerebral artery infarction. Human ortholog(s) of this gene implicated in APP-related cerebral amyloid angiopathy; Alzheimer's disease (multiple); cognitive disorder; traumatic brain injury; and visual epilepsy. Orthologous to human APP (amyloid beta precursor protein); PARTICIPATES IN glypican signaling pathway; Alzheimer's disease pathway; INTERACTS WITH (+)-catechin; (S)-naringenin; (S)-nicotine.
Type: protein-coding
Previously known as: Abeta; ABPP; AG; alzheimer disease amyloid A4 protein homolog; amyloid A4; amyloid beta (A4) precursor protein; amyloid beta A4 protein; amyloidogenic glycoprotein
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Appem1Sage  
Genetic Models: SD-Appem1Sage
Candidate Gene For: Edcs1
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr81137,506,207 - 37,724,351 (-)NCBIGRCr8
mRatBN7.21124,019,774 - 24,236,584 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1124,019,778 - 24,236,561 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1132,713,957 - 32,929,750 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01125,414,338 - 25,630,128 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01124,603,106 - 24,818,898 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01124,425,013 - 24,641,872 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1124,425,005 - 24,641,858 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01128,048,897 - 28,265,250 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41124,457,855 - 24,693,851 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11124,457,854 - 24,693,851 (-)NCBI
Celera1123,853,696 - 24,069,048 (-)NCBICelera
RH 3.4 Map1194.7RGD
Cytogenetic Map11q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
(24S)-24-hydroxycholesterol  (ISO)
(25R)-cholest-5-ene-3beta,26-diol  (ISO)
(5Z,8Z,11Z,13E)-15-HETE  (ISO)
(R)-carnitine  (ISO)
(R,R,R)-alpha-tocopherol  (ISO)
(S)-naringenin  (EXP)
(S)-nicotine  (EXP,ISO)
(Z)-ligustilide  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (EXP,ISO)
1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,2,2-tetramine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-dihydroxybenzoic acid  (ISO)
2,4-dinitrophenol  (ISO)
2,5-dihydroxybenzoic acid  (ISO)
2,6-dinitrotoluene  (EXP)
2-deoxy-D-glucose  (ISO)
2-ethoxyethanol  (EXP)
2-methoxyethanol  (EXP)
26-hydroxycholesterol  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP,ISO)
3,3',5-triiodo-L-thyronine  (EXP,ISO)
3,4-dihydroxybenzoic acid  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-methyladenine  (ISO)
3-nitrophenol  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (EXP)
4,7-diphenyl-1,10-phenanthroline  (ISO)
4-hydroxynon-2-enal  (ISO)
4-phenylbutyric acid  (EXP)
5,6,7,8-tetrahydrobiopterin  (ISO)
5-azacytidine  (ISO)
5-chloro-7-iodoquinolin-8-ol  (ISO)
5-methoxypsoralen  (ISO)
7alpha-hydroxycholesterol  (EXP)
8-epi-prostaglandin F2alpha  (ISO)
9-cis-retinoic acid  (ISO)
acetamide  (EXP)
acetyl-CoA  (ISO)
acetylcholine  (EXP,ISO)
acetylsalicylic acid  (ISO)
acrolein  (EXP,ISO)
aflatoxin B1  (EXP,ISO)
agmatine  (ISO)
AICA ribonucleotide  (ISO)
aldicarb  (ISO)
alendronic acid  (ISO)
all-trans-retinoic acid  (EXP,ISO)
all-trans-retinol  (EXP)
alpha-D-galactose  (ISO)
alpha-hexachlorocyclohexane  (EXP)
alpha-pinene  (ISO)
aluminium atom  (EXP,ISO)
aluminium sulfate (anhydrous)  (ISO)
aluminium(0)  (EXP,ISO)
ambenonium chloride  (EXP)
aminoguanidine  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
anandamide  (EXP,ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
arachidonic acid  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenic trichloride  (ISO)
arsenous acid  (ISO)
astaxanthin  (ISO)
atorvastatin calcium  (ISO)
atrazine  (EXP)
azure B  (ISO)
baicalein  (EXP)
benzene  (ISO)
benzo[a]pyrene  (ISO)
berberine  (EXP)
Bergenin  (EXP)
bethanechol  (EXP)
bexarotene  (EXP)
bilobalide  (ISO)
biotin  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bisdemethoxycurcumin  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (EXP)
bisphenol F  (EXP,ISO)
buspirone  (EXP)
buten-2-one  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
calcium atom  (EXP,ISO)
calcium(0)  (EXP,ISO)
calycosin  (EXP)
cannabidiol  (ISO)
carbachol  (ISO)
carbon nanotube  (ISO)
carnosine  (ISO)
carvedilol  (ISO)
celecoxib  (ISO)
chloropicrin  (ISO)
chloroquine  (EXP)
chlorpyrifos  (ISO)
cholesterol  (EXP,ISO)
choline  (ISO)
cilostazol  (ISO)
cis-caffeic acid  (ISO)
clofibrate  (EXP)
clofibric acid  (EXP)
clozapine  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (ISO)
cocaine  (EXP,ISO)
coenzyme Q10  (EXP)
Congo Red  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (EXP,ISO)
cordycepin  (EXP)
coumestrol  (ISO)
creatine  (ISO)
crocidolite asbestos  (ISO)
curcumin  (EXP,ISO)
cyclosporin A  (ISO)
cyprodinil  (ISO)
D-penicillamine  (ISO)
decabromodiphenyl ether  (EXP,ISO)
demethoxycurcumin  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (EXP)
dextran sulfate  (ISO)
Di-n-octyl phthalate  (ISO)
diarsenic trioxide  (ISO)
dichlorvos  (EXP,ISO)
Didymin  (ISO)
dieldrin  (EXP)
diethyldithiocarbamic acid  (ISO)
dihydrogen  (ISO)
dimercaprol  (ISO)
dimethylarsinic acid  (ISO)
diminazene diaceturate  (ISO)
diprotium  (ISO)
disodium selenite  (ISO)
disulfiram  (ISO)
diuron  (EXP)
dizocilpine maleate  (EXP)
donepezil hydrochloride  (EXP,ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
duvoglustat  (ISO)
edaravone  (EXP)
elemental selenium  (ISO)
ellagic acid  (EXP)
enzalutamide  (ISO)
ethanol  (ISO)
ethosuximide  (EXP)
ethylenediaminetetraacetic acid  (ISO)
farrerol  (EXP)
fenofibrate  (ISO)
ferroheme b  (ISO)
finasteride  (EXP)
fipronil  (EXP)
fisetin  (ISO)
flurbiprofen  (EXP,ISO)
flutamide  (EXP)
folic acid  (ISO)
folpet  (ISO)
fonofos  (ISO)
fulvestrant  (EXP,ISO)
fumonisin B1  (ISO)
furan  (EXP)
galactose  (ISO)
galanthamine  (ISO)
galanthamine Trifluoroacetic acid  (ISO)
gallic acid  (ISO)
gamma-tocopherol  (EXP)
genistein  (ISO)
gentamycin  (EXP)
ginkgolide B  (ISO)
Ginkgolide C  (ISO)
ginsenoside Rd  (EXP)
ginsenoside Rg1  (EXP)
ginsenoside Rg2  (EXP)
glutathione  (EXP,ISO)
glycine betaine  (ISO)
glycitin  (EXP)
glyphosate  (ISO)
Goe 6976  (ISO)
GW 501516  (ISO)
heme b  (ISO)
heparin  (ISO)
heroin  (ISO)
hexaconazole  (ISO)
hexadecanoic acid  (ISO)
homocysteine  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
ibuprofen  (EXP,ISO)
icariin  (EXP)
idarubicin  (ISO)
indole-3-methanol  (EXP)
indometacin  (EXP,ISO)
inulin  (ISO)
iron atom  (ISO)
iron(0)  (ISO)
iron(2+) sulfate (anhydrous)  (EXP)
isoflurane  (ISO)
isoniazide  (ISO)
ivermectin  (ISO)
kaempferol  (EXP)
kaempferol 3-O-beta-D-glucoside  (ISO)
ketamine  (ISO)
kojic acid  (ISO)
KT 5720  (ISO)
KT 5823  (ISO)
L-ascorbic acid  (EXP,ISO)
L-erythro-7,8-dihydrobiopterin  (ISO)
L-methionine  (ISO)
L-serine  (EXP)
lactacystin  (ISO)
lead diacetate  (EXP,ISO)
lead tetraacetate  (ISO)
lead(0)  (EXP,ISO)
lipopolysaccharide  (EXP,ISO)
lithium atom  (EXP,ISO)
lithium chloride  (ISO)
lithium hydride  (EXP,ISO)
lovastatin  (EXP,ISO)
LY294002  (EXP,ISO)
malonaldehyde  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
Mecamylamine  (ISO)
melatonin  (EXP,ISO)
meloxicam  (ISO)
memantine  (EXP)
mepanipyrim  (ISO)
mercury atom  (ISO)
mercury dichloride  (ISO)
mercury(0)  (ISO)
methamphetamine  (EXP,ISO)
methapyrilene  (EXP)
methidathion  (ISO)
methotrexate  (ISO)
methoxychlor  (EXP)
methyllycaconitine  (EXP,ISO)
Methysticin  (ISO)
minocycline  (EXP,ISO)
miquelianin  (ISO)
mitomycin C  (ISO)
monensin A  (ISO)
morin  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
neoechinulin A  (ISO)
nickel atom  (ISO)
nicotine  (EXP,ISO)
nimodipine  (EXP)
nitric oxide  (ISO)
nitroprusside  (ISO)
notoginsenoside R1  (EXP,ISO)
ochratoxin A  (ISO)
okadaic acid  (ISO)
olanzapine  (EXP)
orlistat  (ISO)
orphenadrine  (EXP)
ozone  (ISO)
p-anisidine  (ISO)
p-menthan-3-ol  (ISO)
paracetamol  (ISO)
paraquat  (EXP,ISO)
parathion  (ISO)
paroxetine  (ISO)
PCB138  (ISO)
pentetrazol  (EXP)
pentobarbital  (EXP)
perfluorobutanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
permethrin  (EXP)
phenobarbital  (EXP)
phlorizin  (ISO)
phorbol 12,13-dibutanoate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosphatidylcholine  (ISO)
phosphoenolpyruvate  (ISO)
physostigmine  (EXP)
pifithrin-?  (EXP)
pioglitazone  (ISO)
piperidine  (ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP,ISO)
poly(I:C)  (EXP)
poly(vinylpyrrolidone)  (ISO)
potassium atom  (EXP)
potassium bromate  (ISO)
pravastatin  (ISO)
pregnenolone  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP)
proanthocyanidin  (EXP)
probucol  (EXP)
progesterone  (ISO)
propiconazole  (EXP)
prostaglandin D2  (ISO)
prostaglandin E2  (EXP,ISO)
prucalopride  (ISO)
pyrimethanil  (ISO)
pyrogallol  (ISO)
pyrrolidine dithiocarbamate  (ISO)
quercetin  (ISO)
quetiapine fumarate  (EXP)
quinine  (ISO)
raloxifene  (ISO)
reactive nitrogen species  (ISO)
reactive oxygen species  (EXP,ISO)
resveratrol  (EXP,ISO)
rimonabant  (ISO)
rotenone  (ISO)
rottlerin  (EXP)
ruthenium red  (EXP)
S-adenosyl-L-homocysteine  (ISO)
S-adenosyl-L-methioninate  (ISO)
S-adenosyl-L-methionine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP)
salicylates  (EXP)
sapropterin  (ISO)
sarin  (ISO)
SB 203580  (ISO)
SB 415286  (ISO)
SB 431542  (ISO)
SCH772984  (EXP)
scopolamine  (ISO)
scutellarin  (EXP)
selenium atom  (ISO)
selenomethionine  (EXP)
serotonin  (ISO)
sevoflurane  (EXP,ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (EXP,ISO)
sirolimus  (ISO)
sirtinol  (ISO)
sodium arsenite  (ISO)
sodium azide  (EXP,ISO)
sodium dichromate  (EXP)
sodium nitrite  (ISO)
staurosporine  (ISO)
streptozocin  (EXP,ISO)
sulfur dioxide  (EXP)
sulindac  (ISO)
sulindac sulfide  (EXP,ISO)
superoxide  (ISO)
T-2 toxin  (EXP)
tadalafil  (ISO)
tamoxifen  (EXP,ISO)
tauroursodeoxycholic acid  (EXP,ISO)
terbufos  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP,ISO)
tetrahydrocurcumin  (ISO)
tetrathiomolybdate(2-)  (ISO)
tetrodotoxin  (ISO)
thapsigargin  (EXP)
thiethylperazine  (ISO)
thioacetamide  (EXP)
thiourea  (ISO)
thymoquinone  (EXP)
thyroxine  (ISO)
titanium dioxide  (ISO)
tocopherol  (EXP)
tolfenamic acid  (ISO)
tolonium chloride  (ISO)
toluene  (EXP)
trans-caffeic acid  (ISO)
trenbolone  (EXP)
triadimefon  (EXP)
trichlorfon  (EXP,ISO)
trilostane  (EXP)
trimellitic anhydride  (ISO)
triolein  (EXP)
triphenyl phosphate  (EXP)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (ISO)
tubocurarine  (ISO)
tunicamycin  (ISO)
uranium atom  (ISO)
urethane  (ISO)
ursolic acid  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)
vitamin E  (EXP,ISO)
vitexin  (ISO)
WIN 55212-2  (ISO)
Y-27632  (EXP,ISO)
zebularine  (ISO)
zinc atom  (EXP,ISO)
zinc sulfate  (EXP)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenylate cyclase-activating G protein-coupled receptor signaling pathway  (ISO)
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway  (ISO)
adult locomotory behavior  (IEA,ISO,ISS)
amyloid fibril formation  (IEA,ISO)
antibacterial humoral response  (IDA)
antifungal humoral response  (IDA)
antimicrobial humoral immune response mediated by antimicrobial peptide  (IDA,ISO)
associative learning  (ISO)
astrocyte activation  (ISO)
astrocyte activation involved in immune response  (IEA,ISO)
axo-dendritic transport  (IEA,ISO,ISS)
axon midline choice point recognition  (IEA,ISO,ISS)
axonogenesis  (IBA,IEA,ISO,ISS)
calcium-mediated signaling  (ISO)
cell adhesion  (IEA)
cellular response to amyloid-beta  (IEA,ISO)
cellular response to cAMP  (IEP)
cellular response to copper ion  (IEP)
cellular response to manganese ion  (IEP)
cellular response to nerve growth factor stimulus  (IEP)
cellular response to norepinephrine stimulus  (IMP)
central nervous system development  (IBA,IEA)
chemical synaptic transmission  (ISO)
cholesterol metabolic process  (IEA,ISO)
cognition  (ISO,ISS)
collateral sprouting in absence of injury  (IEA,ISO,ISS)
cytosolic mRNA polyadenylation  (IEA,ISO)
defense response to Gram-negative bacterium  (IDA)
defense response to Gram-positive bacterium  (IDA)
dendrite development  (IEA,ISO,ISS)
endocytosis  (IEA,ISO,ISS)
extracellular matrix organization  (IEA,ISO,ISS)
forebrain development  (IEA,ISO)
G protein-coupled receptor signaling pathway  (ISO)
G2/M transition of mitotic cell cycle  (IEA,ISO)
innate immune response  (IDA,ISO)
intracellular copper ion homeostasis  (IEA,ISO,ISS)
ionotropic glutamate receptor signaling pathway  (IEA,ISO,ISS)
learning  (ISO)
learning or memory  (ISO)
locomotory behavior  (ISO,ISS)
low-density lipoprotein particle mediated signaling  (ISO)
mating behavior  (IEA,ISO,ISS)
memory  (ISO)
microglia development  (IEA,ISO)
microglial cell activation  (IEA,ISO)
mitotic cell cycle  (ISO)
modulation of excitatory postsynaptic potential  (IEA,ISO)
negative regulation of blood circulation  (ISO)
negative regulation of canonical Wnt signaling pathway