(+)-catechin decreases response to substance EXP 6480464 Catechin results in decreased susceptibility to APP protein CTD PMID:15134381 (+)-catechin multiple interactions EXP 6480464 resveratrol promotes the reaction [Catechin results in decreased susceptibility to APP protein] CTD PMID:15134381 (-)-epigallocatechin 3-gallate affects folding ISO RGD:736021 6480464 epigallocatechin gallate affects the folding of APP protein modified form CTD PMID:23386614 (1->4)-beta-D-glucan multiple interactions ISO RGD:736022 6480464 [perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of APP mRNA CTD PMID:36331819 (24S)-24-hydroxycholesterol multiple interactions ISO RGD:736021 6480464 24-hydroxycholesterol affects the metabolism of and results in increased activity of APP protein, 24-hydroxycholesterol results in decreased metabolism of and results in decreased secretion of APP protein CTD PMID:15148325 , PMID:17532301 (24S)-24-hydroxycholesterol increases metabolic processing ISO RGD:736021 6480464 24-hydroxycholesterol results in increased metabolism of APP protein CTD PMID:19126211 (25R)-cholest-5-ene-3beta,26-diol multiple interactions ISO RGD:736021 6480464 27-hydroxycholesterol results in decreased metabolism of and results in decreased secretion of APP protein CTD PMID:15148325 (25R)-cholest-5-ene-3beta,26-diol increases expression ISO RGD:736021 6480464 27-hydroxycholesterol results in increased expression of APP protein alternative form CTD PMID:19126211 (25R)-cholest-5-ene-3beta,26-diol decreases secretion ISO RGD:736021 6480464 27-hydroxycholesterol results in decreased secretion of APP protein alternative form CTD PMID:19158428 (5Z,8Z,11Z,13E)-15-HETE increases secretion ISO RGD:736021 6480464 APP protein modified form results in increased secretion of 15-hydroxy-5 more ... CTD PMID:28721267 (5Z,8Z,11Z,13E)-15-HETE multiple interactions ISO RGD:736021 6480464 CNB 001 inhibits the reaction [APP protein modified form results in increased secretion of 15-hydroxy-5 more ... CTD PMID:28721267 (R)-carnitine multiple interactions ISO RGD:736021 6480464 Carnitine promotes the reaction [Paraquat deficiency inhibits the reaction [Paraquat promotes the reaction [APP protein binds to APP protein]]] CTD PMID:33290254 (R,R,R)-alpha-tocopherol multiple interactions ISO RGD:736021 6480464 alpha-Tocopherol inhibits the reaction [APP protein results in increased activity of MAPK14 protein], alpha-Tocopherol inhibits the reaction [APP protein results in increased activity of MAPK8 protein] CTD PMID:12684028 (S)-naringenin multiple interactions EXP 6480464 naringenin inhibits the reaction [APP protein modified form results in increased abundance of Reactive Oxygen Species] CTD PMID:15030205 (S)-nicotine decreases expression ISO RGD:736021 6480464 Nicotine results in decreased expression of APP mRNA, Nicotine results in decreased expression of APP protein CTD PMID:16627626 (S)-nicotine increases metabolic processing ISO RGD:736021 6480464 Nicotine results in increased metabolism of APP protein CTD PMID:29618714 (S)-nicotine multiple interactions ISO RGD:736021 6480464 [Nicotine results in increased metabolism of APP protein] which results in increased secretion of APP protein modified form more ... CTD PMID:16627626 , PMID:29618714 (S)-nicotine multiple interactions EXP 6480464 APP protein modified form inhibits the reaction [Nicotine results in increased secretion of Acetylcholine] more ... CTD PMID:16474004 (S)-nicotine decreases expression ISO RGD:736022 6480464 Nicotine results in decreased expression of APP protein alternative form CTD PMID:17135361 (Z)-ligustilide decreases expression ISO RGD:736022 6480464 ligustilide results in decreased expression of APP protein CTD PMID:23973442 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane affects expression EXP 6480464 o, p'-DDT affects the expression of APP mRNA CTD PMID:17984292 1,2-dimethylhydrazine multiple interactions ISO RGD:736022 6480464 [1, 2-Dimethylhydrazine co-treated with Folic Acid] results in increased expression of APP mRNA CTD PMID:22206623 1-naphthyl isothiocyanate affects expression EXP 6480464 1-Naphthylisothiocyanate affects the expression of APP mRNA CTD PMID:25380136 1-naphthyl isothiocyanate increases expression EXP 6480464 1-Naphthylisothiocyanate results in increased expression of APP mRNA CTD PMID:30723492 17alpha-ethynylestradiol decreases expression ISO RGD:736022 6480464 Ethinyl Estradiol results in decreased expression of APP mRNA CTD PMID:19400957 17alpha-ethynylestradiol decreases expression EXP 6480464 Ethinyl Estradiol results in decreased expression of APP mRNA CTD PMID:19400957 17alpha-ethynylestradiol multiple interactions ISO RGD:736022 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of APP mRNA CTD PMID:17942748 17alpha-ethynylestradiol increases expression ISO RGD:736022 6480464 Ethinyl Estradiol results in increased expression of APP mRNA CTD PMID:17942748 17alpha-ethynylestradiol affects expression ISO RGD:736022 6480464 Ethinyl Estradiol affects the expression of APP mRNA CTD PMID:17555576 17beta-estradiol multiple interactions ISO RGD:736021 6480464 Estradiol inhibits the reaction [APP protein results in decreased expression of BCL2 protein] more ... CTD PMID:12182891 more ... 17beta-estradiol multiple interactions ISO RGD:736022 6480464 Estradiol inhibits the reaction [[Galactose co-treated with Aluminum Chloride] results in decreased expression of APP protein] CTD PMID:35537655 17beta-estradiol multiple interactions EXP 6480464 [BDNF protein co-treated with MF63 compound co-treated with Estradiol] inhibits the reaction [Paraquat results in increased expression of APP protein alternative form] more ... CTD PMID:31715309 , PMID:32738378 17beta-estradiol decreases expression ISO RGD:736022 6480464 Estradiol results in decreased expression of APP mRNA CTD PMID:22467019 17beta-hydroxy-5alpha-androstan-3-one decreases expression ISO RGD:736022 6480464 Dihydrotestosterone results in decreased expression of APP mRNA CTD PMID:17023530 17beta-hydroxy-5alpha-androstan-3-one multiple interactions EXP 6480464 Dihydrotestosterone promotes the reaction [Trenbolone Acetate analog results in increased expression of APP protein modified form], trilostane inhibits the reaction [Dihydrotestosterone promotes the reaction [Trenbolone Acetate analog results in increased expression of APP protein modified form]] CTD PMID:25461682 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one multiple interactions ISO RGD:736021 6480464 1H-(1 more ... CTD PMID:18001288 2,2',4,4',5,5'-hexachlorobiphenyl multiple interactions ISO RGD:736022 6480464 [2 more ... CTD PMID:26480858 2,2',4,4'-Tetrabromodiphenyl ether increases expression EXP 6480464 2 more ... CTD PMID:27291303 , PMID:32679240 2,2',5,5'-tetrachlorobiphenyl multiple interactions ISO RGD:736022 6480464 [2 more ... CTD PMID:26480858 2,2,2-tetramine multiple interactions ISO RGD:736021 6480464 Trientine inhibits the reaction [[[[APP protein modified form binds to Copper] which co-treated with Ascorbic Acid] results in increased oxidation of phosphatidylcholine hydroperoxide] which results in increased chemical synthesis of 4-hydroxy-2-nonenal] more ... CTD PMID:12963085 , PMID:17964426 2,2,2-tetramine multiple interactions ISO RGD:736022 6480464 Trientine results in decreased expression of and affects the localization of APP protein modified form CTD PMID:23541064 2,2,2-tetramine decreases cleavage ISO RGD:736022 6480464 Trientine results in decreased cleavage of APP protein CTD PMID:23541064 2,2,2-tetramine decreases expression ISO RGD:736021 6480464 Trientine results in decreased expression of APP protein modified form CTD PMID:23541064 2,2,2-tetramine increases metabolic processing ISO RGD:736021 6480464 Trientine results in increased metabolism of APP protein CTD PMID:10940226 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:736022 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of APP mRNA, Tetrachlorodibenzodioxin affects the reaction [AHR protein binds to APP promoter] CTD PMID:17942748 , PMID:19654925 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of APP mRNA CTD PMID:34747641 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:736022 6480464 Tetrachlorodibenzodioxin affects the expression of APP mRNA CTD PMID:21570461 2,3-dihydroxybenzoic acid multiple interactions ISO RGD:736021 6480464 2 more ... CTD PMID:22129351 2,4-dinitrophenol affects localization ISO RGD:736022 6480464 2, 4-Dinitrophenol affects the localization of APP protein CTD PMID:18949129 2,4-dinitrophenol multiple interactions ISO RGD:736022 6480464 2, 4-Dinitrophenol affects the reaction [APP protein affects the abundance of Calcium] CTD PMID:18949129 2,5-dihydroxybenzoic acid multiple interactions ISO RGD:736021 6480464 2 more ... CTD PMID:22129351 2,6-dinitrotoluene affects expression EXP 6480464 2, 6-dinitrotoluene affects the expression of APP mRNA CTD PMID:21346803 2-deoxy-D-glucose multiple interactions ISO RGD:736021 6480464 [Sodium Azide co-treated with Deoxyglucose] affects the cleavage of and affects the localization of APP protein CTD PMID:17405930 2-ethoxyethanol increases expression EXP 6480464 2-ethoxyethanol results in increased expression of APP mRNA CTD PMID:19643169 2-methoxyethanol increases expression EXP 6480464 methyl cellosolve results in increased expression of APP mRNA CTD PMID:19643169 26-hydroxycholesterol multiple interactions ISO RGD:736021 6480464 27-hydroxycholesterol results in decreased metabolism of and results in decreased secretion of APP protein CTD PMID:15148325 26-hydroxycholesterol decreases secretion ISO RGD:736021 6480464 27-hydroxycholesterol results in decreased secretion of APP protein alternative form CTD PMID:19158428 26-hydroxycholesterol increases expression ISO RGD:736021 6480464 27-hydroxycholesterol results in increased expression of APP protein alternative form CTD PMID:19126211 3,3',5,5'-tetrabromobisphenol A increases secretion ISO RGD:736021 6480464 tetrabromobisphenol A results in increased secretion of APP protein modified form CTD PMID:22485137 3,3',5,5'-tetrabromobisphenol A decreases expression EXP 6480464 tetrabromobisphenol A results in decreased expression of APP mRNA CTD PMID:28970181 3,3',5-triiodo-L-thyronine decreases expression ISO RGD:736021 6480464 Triiodothyronine results in decreased expression of APP mRNA, Triiodothyronine results in decreased expression of APP protein CTD PMID:17199430 3,3',5-triiodo-L-thyronine multiple interactions ISO RGD:736021 6480464 Tretinoin promotes the reaction [Triiodothyronine results in decreased secretion of APP protein] CTD PMID:17199430 3,4-dihydroxybenzoic acid multiple interactions ISO RGD:736021 6480464 Gallic Acid inhibits the reaction [protocatechuic acid inhibits the reaction [APP protein modified form binds to APP protein modified form]], protocatechuic acid inhibits the reaction [APP protein modified form binds to APP protein modified form] CTD PMID:22129351 3-chloropropane-1,2-diol decreases expression EXP 6480464 alpha-Chlorohydrin results in decreased expression of APP mRNA CTD PMID:20409345 3-methyladenine multiple interactions ISO RGD:736021 6480464 [Hydrogen Peroxide co-treated with 3-methyladenine] results in increased expression of APP protein CTD PMID:23726866 3-nitrophenol affects localization ISO RGD:736022 6480464 3-nitrophenol affects the localization of APP protein CTD PMID:18949129 3-nitrophenol multiple interactions ISO RGD:736022 6480464 3-nitrophenol affects the reaction [APP protein affects the abundance of Calcium] CTD PMID:18949129 3H-1,2-dithiole-3-thione decreases expression EXP 6480464 1, 2-dithiol-3-thione results in decreased expression of APP mRNA CTD PMID:19162173 4,4'-diaminodiphenylmethane affects expression EXP 6480464 4, 4'-diaminodiphenylmethane affects the expression of APP mRNA CTD PMID:25380136 4,4'-sulfonyldiphenol multiple interactions EXP 6480464 [bisphenol A co-treated with bisphenol F co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of APP mRNA CTD PMID:36041667 4,7-diphenyl-1,10-phenanthroline increases metabolic processing ISO RGD:736021 6480464 bathophenanthroline results in increased metabolism of APP protein CTD PMID:10940226 4-hydroxynon-2-enal multiple interactions ISO RGD:736021 6480464 [[[APP protein modified form binds to Copper] which co-treated with Ascorbic Acid] results in increased oxidation of phosphatidylcholine hydroperoxide] which results in increased chemical synthesis of 4-hydroxy-2-nonenal more ... CTD PMID:17964426 4-hydroxynon-2-enal decreases expression ISO RGD:736021 6480464 4-hydroxy-2-nonenal results in decreased expression of APP mRNA CTD PMID:12419474 4-phenylbutyric acid affects activity EXP 6480464 4-phenylbutyric acid affects the activity of APP protein CTD PMID:16204253 5,6,7,8-tetrahydrobiopterin multiple interactions ISO RGD:736021 6480464 APP gene mutant form results in increased oxidation of and results in decreased abundance of sapropterin, GW 501516 inhibits the reaction [APP gene mutant form results in increased oxidation of and results in decreased abundance of sapropterin] CTD PMID:22886847 5-azacytidine decreases methylation ISO RGD:736022 6480464 Azacitidine results in decreased methylation of APP promoter CTD PMID:19635394 5-azacytidine multiple interactions ISO RGD:736022 6480464 Azacitidine results in increased expression of and results in increased cleavage of APP protein more ... CTD PMID:19635394 5-chloro-7-iodoquinolin-8-ol multiple interactions ISO RGD:736021 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Clioquinol binds to Copper] which results in increased degradation of APP protein modified form] more ... CTD PMID:16648635 , PMID:18346929 5-methoxypsoralen multiple interactions ISO RGD:736022 6480464 5-Methoxypsoralen inhibits the reaction [Streptozocin results in increased expression of APP protein modified form] CTD PMID:34428446 7alpha-hydroxycholesterol increases chemical synthesis EXP 6480464 APP protein results in increased chemical synthesis of cholest-5-en-3 beta, 7 alpha-diol CTD PMID:15591071 7alpha-hydroxycholesterol decreases secretion EXP 6480464 cholest-5-en-3 beta, 7 alpha-diol results in decreased secretion of APP protein CTD PMID:15591071 8-epi-prostaglandin F2alpha increases abundance ISO RGD:736021 6480464 APP protein modified form results in increased abundance of 8-epi-prostaglandin F2alpha CTD PMID:22610977 8-epi-prostaglandin F2alpha multiple interactions ISO RGD:736021 6480464 [Lead co-treated with APP protein modified form] results in increased abundance of 8-epi-prostaglandin F2alpha CTD PMID:22610977 9-cis-retinoic acid multiple interactions ISO RGD:736021 6480464 Alitretinoin inhibits the reaction [Flurbiprofen results in decreased secretion of APP protein] CTD PMID:19659691 acetamide increases expression EXP 6480464 acetamide results in increased expression of APP mRNA CTD PMID:31881176 acetyl-CoA affects localization ISO RGD:736022 6480464 APP protein affects the localization of Acetyl Coenzyme A CTD PMID:16122837 acetyl-CoA increases secretion ISO RGD:736021 6480464 Acetyl Coenzyme A results in increased secretion of APP protein modified form CTD PMID:22906069 acetyl-CoA multiple interactions ISO RGD:736021 6480464 Acetyl Coenzyme A inhibits the reaction [Hydrogen Peroxide results in decreased secretion of APP protein modified form] CTD PMID:22906069 acetyl-CoA multiple interactions ISO RGD:736022 6480464 IL1B protein affects the reaction [APP protein affects the localization of Acetyl Coenzyme A] CTD PMID:16122837 acetylcholine multiple interactions ISO RGD:736022 6480464 [IL1B protein co-treated with APP protein] results in increased secretion of Acetylcholine, IL1B protein inhibits the reaction [APP protein results in decreased secretion of Acetylcholine] CTD PMID:16122837 acetylcholine multiple interactions ISO RGD:736021 6480464 GW 501516 inhibits the reaction [APP gene mutant form results in decreased susceptibility to Acetylcholine] CTD PMID:22886847 acetylcholine decreases secretion ISO RGD:736022 6480464 APP protein results in decreased secretion of Acetylcholine CTD PMID:16122837 acetylcholine multiple interactions EXP 6480464 APP protein modified form inhibits the reaction [Nicotine results in increased secretion of Acetylcholine] more ... CTD PMID:16474004 acrolein multiple interactions ISO RGD:736021 6480464 [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased expression of and results in increased oxidation of APP mRNA more ... CTD PMID:16081039 , PMID:32699268 acrolein increases expression EXP 6480464 Acrolein results in increased expression of APP protein CTD PMID:29355571 acrolein increases expression ISO RGD:736022 6480464 Acrolein results in increased expression of APP protein CTD PMID:23296102 acrolein affects binding ISO RGD:736021 6480464 [Acrolein binds to APP protein] binds to [Acrolein binds to APP protein], Acrolein binds to APP protein CTD PMID:16081039 aflatoxin B1 decreases expression ISO RGD:736022 6480464 Aflatoxin B1 results in decreased expression of APP mRNA CTD PMID:19770486 aflatoxin B1 increases expression EXP 6480464 Aflatoxin B1 results in increased expression of APP mRNA CTD PMID:22484513 , PMID:33354967 agmatine decreases abundance ISO RGD:736022 6480464 APP protein results in decreased abundance of Agmatine CTD PMID:32522471 agmatine multiple interactions ISO RGD:736022 6480464 Agmatine inhibits the reaction [APP protein results in decreased expression of BDNF protein] more ... CTD PMID:32522471 AICA ribonucleotide decreases expression ISO RGD:736021 6480464 AICA ribonucleotide results in decreased expression of APP protein modified form CTD PMID:20080969 aldicarb decreases response to substance ISO RGD:736021 6480464 APP protein modified form results in decreased susceptibility to Aldicarb CTD PMID:34902447 alendronic acid multiple interactions ISO RGD:736022 6480464 Alendronate inhibits the reaction [Streptozocin results in increased expression of APP protein] CTD PMID:30481507 all-trans-retinoic acid multiple interactions ISO RGD:736021 6480464 [BDNF protein co-treated with Tretinoin] results in increased expression of APP protein more ... CTD PMID:16150056 more ... all-trans-retinoic acid multiple interactions EXP 6480464 Tretinoin inhibits the reaction [Vitamin A affects the expression of APP mRNA] CTD PMID:16530976 all-trans-retinoic acid increases secretion ISO RGD:736021 6480464 Tretinoin results in increased secretion of APP protein modified form CTD PMID:19476501 all-trans-retinoic acid increases expression ISO RGD:736021 6480464 Tretinoin results in increased expression of APP protein CTD PMID:16150056 all-trans-retinol increases expression EXP 6480464 Vitamin A results in increased expression of APP protein CTD PMID:22274401 all-trans-retinol affects expression EXP 6480464 Vitamin A affects the expression of APP mRNA CTD PMID:16530976 all-trans-retinol multiple interactions EXP 6480464 Tretinoin inhibits the reaction [Vitamin A affects the expression of APP mRNA] CTD PMID:16530976 alpha-D-galactose multiple interactions ISO RGD:736022 6480464 [Galactose co-treated with Aluminum Chloride] results in decreased expression of APP protein more ... CTD PMID:35537655 alpha-hexachlorocyclohexane increases expression EXP 6480464 alpha-hexachlorocyclohexane results in increased expression of APP mRNA CTD PMID:17785943 alpha-pinene multiple interactions ISO RGD:736021 6480464 [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased expression of and results in increased oxidation of APP mRNA, [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased expression of and results in increased oxidation of APP mRNA CTD PMID:32699268 aluminium atom multiple interactions EXP 6480464 [Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of APP mRNA, Berberine inhibits the reaction [[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of APP mRNA] CTD PMID:29170048 aluminium atom increases expression ISO RGD:736021 6480464 Aluminum results in increased expression of APP mRNA CTD PMID:16308480 aluminium atom multiple interactions ISO RGD:736022 6480464 APP protein promotes the reaction [Aluminum results in decreased activity of CHAT protein] more ... CTD PMID:12039845 more ... aluminium atom increases expression ISO RGD:736022 6480464 Aluminum results in increased expression of APP protein CTD PMID:16928369 aluminium atom increases cleavage ISO RGD:736022 6480464 Aluminum results in increased cleavage of APP protein CTD PMID:12039845 aluminium atom affects binding ISO RGD:736021 6480464 APP protein binds to Aluminum CTD PMID:16942756 aluminium atom multiple interactions ISO RGD:736021 6480464 [APP protein modified form binds to Aluminum] which results in increased expression of RCVRN mRNA CTD PMID:21298039 aluminium sulfate (anhydrous) increases expression ISO RGD:736021 6480464 aluminum sulfate results in increased expression of APP mRNA CTD PMID:15961160 aluminium sulfate (anhydrous) affects expression ISO RGD:736022 6480464 aluminum sulfate affects the expression of APP protein CTD PMID:10721010 aluminium(0) multiple interactions ISO RGD:736021 6480464 [APP protein modified form binds to Aluminum] which results in increased expression of RCVRN mRNA CTD PMID:21298039 aluminium(0) increases expression ISO RGD:736021 6480464 Aluminum results in increased expression of APP mRNA CTD PMID:16308480 aluminium(0) multiple interactions ISO RGD:736022 6480464 APP protein promotes the reaction [Aluminum results in decreased activity of CHAT protein] more ... CTD PMID:12039845 more ... aluminium(0) increases expression ISO RGD:736022 6480464 Aluminum results in increased expression of APP protein CTD PMID:16928369 aluminium(0) increases cleavage ISO RGD:736022 6480464 Aluminum results in increased cleavage of APP protein CTD PMID:12039845 aluminium(0) affects binding ISO RGD:736021 6480464 APP protein binds to Aluminum CTD PMID:16942756 aluminium(0) multiple interactions EXP 6480464 [Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of APP mRNA, Berberine inhibits the reaction [[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of APP mRNA] CTD PMID:29170048 ambenonium chloride affects cleavage EXP 6480464 Ambenonium Chloride affects the cleavage of APP protein CTD PMID:11099780 aminoguanidine multiple interactions ISO RGD:736021 6480464 pimagedine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of APP mRNA], pimagedine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of APP protein] CTD PMID:28242320 amitrole affects activity EXP 6480464 Amitrole affects the activity of APP protein CTD PMID:16204253 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of APP mRNA CTD PMID:16483693 ammonium chloride decreases expression EXP 6480464 Ammonium Chloride results in decreased expression of APP protein CTD PMID:16483693 anandamide decreases response to substance EXP 6480464 anandamide results in decreased susceptibility to APP protein CTD PMID:22233683 anandamide decreases metabolic processing ISO RGD:736022 6480464 APP protein results in decreased metabolism of anandamide CTD PMID:26976670 anandamide decreases abundance ISO RGD:736022 6480464 APP protein results in decreased abundance of anandamide CTD PMID:26976670 anthra[1,9-cd]pyrazol-6(2H)-one multiple interactions ISO RGD:736021 6480464 pyrazolanthrone inhibits the reaction [[Clioquinol co-treated with Copper] results in decreased expression of APP protein alternative form] more ... CTD PMID:16648635 , PMID:28004443 arachidonic acid increases secretion ISO RGD:736021 6480464 APP protein modified form results in increased secretion of Arachidonic Acid CTD PMID:28721267 arachidonic acid multiple interactions ISO RGD:736021 6480464 [1 more ... CTD PMID:28721267 aristolochic acid A decreases expression ISO RGD:736021 6480464 aristolochic acid I results in decreased expression of APP mRNA, aristolochic acid I results in decreased expression of APP protein CTD PMID:33212167 Aroclor 1254 decreases expression ISO RGD:736022 6480464 Chlorodiphenyl (54% Chlorine) results in decreased expression of APP mRNA CTD PMID:23650126 arsane increases cleavage EXP 6480464 Arsenic results in increased cleavage of APP protein CTD PMID:29155576 arsane multiple interactions ISO RGD:736021 6480464 [Palmitic Acid co-treated with Arsenic] affects the expression of APP mRNA CTD PMID:33736254 arsane increases expression EXP 6480464 Arsenic results in increased expression of APP protein, Arsenic results in increased expression of APP protein modified form CTD PMID:25288670 , PMID:29155576 arsane multiple interactions EXP 6480464 [Arsenic co-treated with Cadmium co-treated with Lead] promotes the reaction [BACE1 protein results in increased metabolism of APP protein] more ... CTD PMID:25288670 arsane affects methylation ISO RGD:736021 6480464 Arsenic affects the methylation of APP gene CTD PMID:25304211 arsenic atom increases cleavage EXP 6480464 Arsenic results in increased cleavage of APP protein CTD PMID:29155576 arsenic atom multiple interactions ISO RGD:736021 6480464 [Palmitic Acid co-treated with Arsenic] affects the expression of APP mRNA CTD PMID:33736254 arsenic atom increases expression EXP 6480464 Arsenic results in increased expression of APP protein, Arsenic results in increased expression of APP protein modified form CTD PMID:25288670 , PMID:29155576 arsenic atom multiple interactions EXP 6480464 [Arsenic co-treated with Cadmium co-treated with Lead] promotes the reaction [BACE1 protein results in increased metabolism of APP protein] more ... CTD PMID:25288670 arsenic atom affects methylation ISO RGD:736021 6480464 Arsenic affects the methylation of APP gene CTD PMID:25304211 arsenous acid increases expression ISO RGD:736021 6480464 Arsenic Trioxide results in increased expression of APP mRNA CTD PMID:20458559 astaxanthin multiple interactions ISO RGD:736022 6480464 astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of APP mRNA] CTD PMID:16964424 atorvastatin calcium multiple interactions ISO RGD:736022 6480464 Atorvastatin inhibits the reaction [APP protein results in decreased expression of SLC1A2 protein], Atorvastatin inhibits the reaction [APP protein results in decreased expression of SLC1A3 protein] CTD PMID:20816828 ATP multiple interactions ISO RGD:736021 6480464 Adenosine Triphosphate inhibits the reaction [Hydrogen Peroxide results in decreased secretion of APP protein modified form] more ... CTD PMID:22906069 ATP increases secretion ISO RGD:736021 6480464 Adenosine Triphosphate results in increased secretion of APP protein modified form CTD PMID:22906069 atrazine affects methylation EXP 6480464 Atrazine affects the methylation of APP gene CTD PMID:28931070 azure B multiple interactions ISO RGD:736021 6480464 [Azure B affects the cleavage of APP protein] which results in decreased secretion of APP protein modified form, Azure B results in decreased expression of and affects the cleavage of APP protein CTD PMID:30500345 baicalein multiple interactions EXP 6480464 baicalein inhibits the reaction [APP protein binds to APP protein] CTD PMID:17323972 benzene multiple interactions ISO RGD:736021 6480464 Benzene analog inhibits the reaction [APP protein binds to APP protein] CTD PMID:15707952 benzene affects binding ISO RGD:736021 6480464 Benzene analog binds to APP protein CTD PMID:15707952 benzo[a]pyrene decreases expression ISO RGD:736022 6480464 Benzo(a)pyrene results in decreased expression of APP mRNA CTD PMID:19770486 benzo[a]pyrene decreases methylation ISO RGD:736021 6480464 Benzo(a)pyrene results in decreased methylation of APP 3' UTR CTD PMID:27901495 benzo[a]pyrene increases expression ISO RGD:736021 6480464 Benzo(a)pyrene results in increased expression of APP mRNA, Benzo(a)pyrene results in increased expression of APP protein CTD PMID:22316170 , PMID:25596431 benzo[a]pyrene multiple interactions ISO RGD:736022 6480464 Benzo(a)pyrene promotes the reaction [AHR protein binds to APP promoter] CTD PMID:19654925 berberine multiple interactions EXP 6480464 Berberine inhibits the reaction [[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of APP mRNA] CTD PMID:29170048 bethanechol increases secretion EXP 6480464 Bethanechol results in increased secretion of APP protein modified form CTD PMID:7605915 , PMID:8624119 bexarotene increases expression EXP 6480464 bexarotene results in increased expression of APP mRNA CTD PMID:16648578 bilobalide multiple interactions ISO RGD:736021 6480464 bilobalide inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein] CTD PMID:18001288 biotin multiple interactions EXP 6480464 [Biotin co-treated with coenzyme Q10] inhibits the reaction [Aluminum Chloride results in increased expression of APP protein], Biotin inhibits the reaction [Aluminum Chloride results in increased expression of APP protein] CTD PMID:32383521 bis(2-chloroethyl) sulfide decreases expression ISO RGD:736022 6480464 Mustard Gas results in decreased expression of APP mRNA CTD PMID:15674843 bisdemethoxycurcumin multiple interactions ISO RGD:736021 6480464 [bisdemethoxycurcumin analog co-treated with APP protein] results in increased expression of MGAT3 mRNA more ... CTD PMID:19715544 , PMID:22029407 bisphenol A increases expression ISO RGD:736022 6480464 bisphenol A results in increased expression of APP mRNA, bisphenol A results in increased expression of APP protein CTD PMID:26063408 more ... bisphenol A multiple interactions EXP 6480464 [bisphenol A co-treated with bisphenol F co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of APP mRNA CTD PMID:36041667 bisphenol A decreases methylation ISO RGD:736021 6480464 bisphenol A results in decreased methylation of APP gene CTD PMID:31601247 bisphenol A multiple interactions ISO RGD:736021 6480464 [bisphenol A co-treated with Fulvestrant] results in decreased methylation of APP gene CTD PMID:31601247 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of APP mRNA CTD PMID:34947998 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of APP mRNA, bisphenol A results in increased expression of APP protein modified form CTD PMID:25181051 , PMID:35648353 bisphenol F decreases expression EXP 6480464 4, 4'-bisphenol F results in decreased expression of APP mRNA CTD PMID:26186136 bisphenol F multiple interactions EXP 6480464 [bisphenol A co-treated with bisphenol F co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of APP mRNA CTD PMID:36041667 bisphenol F multiple interactions ISO RGD:736021 6480464 [bisphenol F co-treated with Fulvestrant] results in decreased methylation of APP gene CTD PMID:31601247 buspirone decreases expression EXP 6480464 Buspirone results in decreased expression of APP mRNA CTD PMID:24136188 buten-2-one multiple interactions ISO RGD:736021 6480464 [3-buten-2-one results in increased metabolism of APP protein] which results in increased secretion of APP protein modified form CTD PMID:29618714 cadmium atom affects binding ISO RGD:736021 6480464 Cadmium binds to APP protein CTD PMID:16266835 cadmium atom multiple interactions ISO RGD:736021 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of APP mRNA CTD PMID:29741670 cadmium atom increases expression EXP 6480464 Cadmium results in increased expression of APP protein CTD PMID:25288670 cadmium atom multiple interactions EXP 6480464 [Arsenic co-treated with Cadmium co-treated with Lead] promotes the reaction [BACE1 protein results in increased metabolism of APP protein] more ... CTD PMID:25288670 , PMID:29170048 cadmium dichloride multiple interactions ISO RGD:736022 6480464 [[Cadmium Chloride results in decreased activity of CHRM1 protein] which affects the expression of ACHE mRNA alternative form] which results in increased expression of APP protein modified form more ... CTD PMID:19840844 more ... cadmium dichloride multiple interactions ISO RGD:736021 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of APP mRNA CTD PMID:29741670 cadmium dichloride increases expression ISO RGD:736022 6480464 Cadmium Chloride results in increased expression of APP protein, Cadmium Chloride results in increased expression of APP protein modified form CTD PMID:26026611 more ... calcium atom multiple interactions ISO RGD:736022 6480464 2 more ... CTD PMID:18949129 calcium atom increases uptake EXP 6480464 APP protein modified form results in increased uptake of Calcium, APP protein results in increased uptake of Calcium CTD PMID:12383957 more ... calcium atom multiple interactions EXP 6480464 Calcium deficiency inhibits the reaction [APP protein modified form results in increased uptake of Calcium] more ... CTD PMID:12383957 more ... calcium atom affects abundance ISO RGD:736022 6480464 APP protein affects the abundance of Calcium CTD PMID:18949129 calcium(0) multiple interactions ISO RGD:736022 6480464 2 more ... CTD PMID:18949129 calcium(0) increases uptake EXP 6480464 APP protein modified form results in increased uptake of Calcium, APP protein results in increased uptake of Calcium CTD PMID:12383957 more ... calcium(0) multiple interactions EXP 6480464 Calcium deficiency inhibits the reaction [APP protein modified form results in increased uptake of Calcium] more ... CTD PMID:12383957 more ... calcium(0) affects abundance ISO RGD:736022 6480464 APP protein affects the abundance of Calcium CTD PMID:18949129 calycosin multiple interactions EXP 6480464 7 more ... CTD PMID:36195188 cannabidiol multiple interactions ISO RGD:736022 6480464 Cannabidiol inhibits the reaction [APP alternative form results in increased expression of IL6 mRNA] CTD PMID:21350020 cannabidiol multiple interactions ISO RGD:736021 6480464 [Cannabidiol co-treated with moringin] results in decreased expression of APP mRNA more ... CTD PMID:27567873 , PMID:30096889 carbachol multiple interactions ISO RGD:736022 6480464 Carbachol inhibits the reaction [APP protein modified form results in decreased expression of BCL2 protein] more ... CTD PMID:10758335 carbon nanotube affects expression ISO RGD:736022 6480464 Nanotubes, Carbon affects the expression of APP mRNA CTD PMID:23845593 carbon nanotube increases expression ISO RGD:736021 6480464 Nanotubes, Carbon results in increased expression of APP mRNA CTD PMID:24389112 carbon nanotube decreases expression ISO RGD:736022 6480464 Nanotubes more ... CTD PMID:25554681 carnosine decreases expression ISO RGD:736022 6480464 Carnosine results in decreased expression of APP protein modified form CTD PMID:21423579 carvedilol decreases expression ISO RGD:736022 6480464 carvedilol results in decreased expression of APP protein modified form CTD PMID:20579773 celecoxib affects cleavage ISO RGD:736022 6480464 Celecoxib affects the cleavage of APP protein CTD PMID:14690522 chloropicrin decreases expression ISO RGD:736021 6480464 chloropicrin results in decreased expression of APP mRNA CTD PMID:28476498 chloropicrin affects expression ISO RGD:736021 6480464 chloropicrin affects the expression of APP mRNA CTD PMID:26352163 chloroquine affects expression EXP 6480464 Chloroquine affects the expression of APP mRNA, Chloroquine affects the expression of APP protein CTD PMID:9690670 chloroquine increases expression EXP 6480464 Chloroquine results in increased expression of APP protein CTD PMID:8616629 chloroquine affects localization EXP 6480464 Chloroquine affects the localization of APP protein CTD PMID:7715800 chloroquine multiple interactions EXP 6480464 Chloroquine affects the localization of and affects the cleavage of APP protein CTD PMID:8787835 chlorpyrifos increases expression ISO RGD:736022 6480464 Chlorpyrifos results in increased expression of APP mRNA more ... CTD PMID:29665406 cholesterol multiple interactions ISO RGD:736022 6480464 [Copper co-treated with Cholesterol] results in increased expression of APP mRNA CTD PMID:17134702 cholesterol increases oxidation EXP 6480464 APP protein results in increased oxidation of Cholesterol CTD PMID:15591071 choline multiple interactions ISO RGD:736022 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of APP mRNA CTD PMID:20938992 cilostazol affects expression ISO RGD:736022 6480464 cilostazol affects the expression of APP protein CTD PMID:24254769 cilostazol multiple interactions ISO RGD:736022 6480464 (E)-3-(2 more ... CTD PMID:24254769 cis-caffeic acid multiple interactions ISO RGD:736022 6480464 caffeic acid inhibits the reaction [aluminum chloride results in increased expression of APP protein modified form], caffeic acid inhibits the reaction [aluminum chloride results in increased expression of APP protein] CTD PMID:18482095 clofibrate decreases expression EXP 6480464 Clofibrate results in decreased expression of APP mRNA CTD PMID:15093671 clofibric acid multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of APP mRNA CTD PMID:17602206 clozapine increases expression ISO RGD:736021 6480464 Clozapine results in increased expression of APP protein CTD PMID:36482696 cobalt atom increases secretion ISO RGD:736021 6480464 Cobalt results in increased secretion of APP protein modified form CTD PMID:12182891 cobalt atom multiple interactions ISO RGD:736021 6480464 Estradiol inhibits the reaction [Cobalt results in increased secretion of APP protein modified form] CTD PMID:12182891 cobalt dichloride decreases expression ISO RGD:736021 6480464 cobaltous chloride results in decreased expression of APP mRNA CTD PMID:19320972 cocaine decreases expression EXP 6480464 Cocaine results in decreased expression of APP mRNA CTD PMID:17898221 cocaine increases expression ISO RGD:736021 6480464 Cocaine results in increased expression of APP mRNA CTD PMID:15009677 , PMID:16710320 coenzyme Q10 decreases response to substance EXP 6480464 coenzyme Q10 results in decreased susceptibility to APP protein CTD PMID:22186599 coenzyme Q10 multiple interactions EXP 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [coenzyme Q10 results in decreased susceptibility to APP protein] more ... CTD PMID:22186599 , PMID:32383521 Congo Red multiple interactions EXP 6480464 Congo Red inhibits the reaction [APP protein binds to APP protein] CTD PMID:17323972 Congo Red affects binding ISO RGD:736021 6480464 Congo Red binds to APP protein CTD PMID:17406451 copper atom multiple interactions ISO RGD:736021 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Clioquinol binds to Copper] which results in increased degradation of APP protein modified form] more ... CTD PMID:11784781 more ... copper atom decreases expression ISO RGD:736021 6480464 Copper deficiency results in decreased expression of APP mRNA, Copper deficiency results in decreased expression of APP protein CTD PMID:14985339 , PMID:18248325 copper atom increases response to substance ISO RGD:736021 6480464 APP protein results in increased susceptibility to Copper CTD PMID:11784781 copper atom increases reduction ISO RGD:736021 6480464 APP protein modified form results in increased reduction of Copper, APP protein results in increased reduction of Copper CTD PMID:12572668 copper atom decreases abundance ISO RGD:736022 6480464 APP protein results in decreased abundance of Copper CTD PMID:12611883 copper atom increases degradation ISO RGD:736021 6480464 Copper results in increased degradation of APP protein modified form CTD PMID:18068270 copper atom increases expression ISO RGD:736021 6480464 Copper deficiency results in increased expression of APP protein modified form more ... CTD PMID:16627626 more ... copper atom affects cleavage ISO RGD:736021 6480464 Copper affects the cleavage of APP protein CTD PMID:18248325 copper atom increases expression ISO RGD:736022 6480464 Copper results in increased expression of APP protein CTD PMID:16886094 copper atom multiple interactions ISO RGD:736022 6480464 [APP gene mutant form co-treated with PSEN1 gene mutant form] results in increased abundance of Copper more ... CTD PMID:15467011 more ... copper atom increases secretion ISO RGD:736022 6480464 APP protein results in increased secretion of Copper CTD PMID:16866297 copper atom increases secretion ISO RGD:736021 6480464 Copper deficiency results in increased secretion of APP protein modified form more ... CTD PMID:16648635 more ... copper atom affects binding ISO RGD:736021 6480464 APP protein binds to Copper more ... CTD PMID:15699049 more ... copper(0) affects binding ISO RGD:736021 6480464 APP protein binds to Copper more ... CTD PMID:15699049 more ... copper(0) decreases expression ISO RGD:736021 6480464 Copper deficiency results in decreased expression of APP mRNA, Copper deficiency results in decreased expression of APP protein CTD PMID:14985339 , PMID:18248325 copper(0) increases response to substance ISO RGD:736021 6480464 APP protein results in increased susceptibility to Copper CTD PMID:11784781 copper(0) increases reduction ISO RGD:736021 6480464 APP protein modified form results in increased reduction of Copper, APP protein results in increased reduction of Copper CTD PMID:12572668 copper(0) decreases abundance ISO RGD:736022 6480464 APP protein results in decreased abundance of Copper CTD PMID:12611883 copper(0) increases degradation ISO RGD:736021 6480464 Copper results in increased degradation of APP protein modified form CTD PMID:18068270 copper(0) increases expression ISO RGD:736021 6480464 Copper deficiency results in increased expression of APP protein modified form more ... CTD PMID:16627626 more ... copper(0) affects cleavage ISO RGD:736021 6480464 Copper affects the cleavage of APP protein CTD PMID:18248325 copper(0) increases expression ISO RGD:736022 6480464 Copper results in increased expression of APP protein CTD PMID:16886094 copper(0) multiple interactions ISO RGD:736022 6480464 [APP gene mutant form co-treated with PSEN1 gene mutant form] results in increased abundance of Copper more ... CTD PMID:15467011 more ... copper(0) increases secretion ISO RGD:736022 6480464 APP protein results in increased secretion of Copper CTD PMID:16866297 copper(0) increases secretion ISO RGD:736021 6480464 Copper deficiency results in increased secretion of APP protein modified form more ... CTD PMID:16648635 more ... copper(0) multiple interactions ISO RGD:736021 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Clioquinol binds to Copper] which results in increased degradation of APP protein modified form] more ... CTD PMID:11784781 more ... copper(II) chloride increases expression EXP 6480464 cupric chloride results in increased expression of APP mRNA, cupric chloride results in increased expression of APP protein CTD PMID:22542740 copper(II) chloride multiple interactions ISO RGD:736022 6480464 cupric chloride results in decreased uptake of and results in decreased degradation of APP protein modified form, PP242 inhibits the reaction [cupric chloride results in decreased uptake of and results in decreased degradation of APP protein modified form] CTD PMID:32512069 copper(II) chloride multiple interactions EXP 6480464 cupric chloride results in decreased uptake of and results in decreased degradation of APP protein modified form CTD PMID:32512069 cordycepin multiple interactions EXP 6480464 1 more ... CTD PMID:30031108 coumestrol decreases expression ISO RGD:736021 6480464 Coumestrol results in decreased expression of APP mRNA CTD PMID:19167446 creatine increases secretion ISO RGD:736021 6480464 Creatine analog results in increased secretion of APP protein modified form CTD PMID:22906069 crocidolite asbestos increases expression ISO RGD:736021 6480464 Asbestos, Crocidolite results in increased expression of APP protein CTD PMID:29553831 CTP increases secretion ISO RGD:736021 6480464 Cytidine Triphosphate results in increased secretion of APP protein modified form CTD PMID:22906069 curcumin multiple interactions ISO RGD:736021 6480464 Curcumin affects the reaction [APP protein binds to APP protein] more ... CTD PMID:18537544 more ... curcumin multiple interactions EXP 6480464 [Curcumin analog co-treated with APP protein modified form] results in increased expression of NFE2L2 protein more ... CTD PMID:30946834 curcumin increases expression ISO RGD:736021 6480464 Curcumin results in increased expression of APP mRNA CTD PMID:31521693 cyclosporin A decreases expression ISO RGD:736021 6480464 Cyclosporine results in decreased expression of APP mRNA CTD PMID:30008028 cyprodinil affects binding ISO RGD:736021 6480464 cyprodinil binds to APP protein modified form CTD PMID:31939705 cyprodinil multiple interactions ISO RGD:736021 6480464 [APP gene mutant form results in increased expression of APP protein modified form] which results in increased susceptibility to cyprodinil more ... CTD PMID:31939705 D-penicillamine multiple interactions ISO RGD:736021 6480464 Penicillamine inhibits the reaction [[[[APP protein modified form binds to Copper] which co-treated with Ascorbic Acid] results in increased oxidation of Phosphatidylcholines] which results in increased chemical synthesis of phosphatidylcholine hydroperoxide], Penicillamine inhibits the reaction [APP protein results in increased activity of CASP3 protein] CTD PMID:12963085 , PMID:17964426 D-penicillamine increases metabolic processing ISO RGD:736021 6480464 Penicillamine results in increased metabolism of APP protein CTD PMID:10940226 DAPT multiple interactions ISO RGD:736021 6480464 N-(N-(3, 5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Tunicamycin results in increased secretion of APP protein modified form] CTD PMID:22115781 DDE increases expression ISO RGD:736021 6480464 Dichlorodiphenyl Dichloroethylene results in increased expression of APP protein CTD PMID:24473795 DDT increases expression ISO RGD:736021 6480464 DDT results in increased expression of APP mRNA, DDT results in increased expression of APP protein CTD PMID:24473795 more ... DDT affects expression ISO RGD:736022 6480464 DDT affects the expression of APP mRNA CTD PMID:35946953 DDT multiple interactions ISO RGD:736022 6480464 Tetrodotoxin inhibits the reaction [DDT results in increased expression of APP mRNA], Tetrodotoxin inhibits the reaction [DDT results in increased expression of APP protein] CTD PMID:35946953 DDT increases expression ISO RGD:736022 6480464 DDT results in increased expression of APP mRNA, DDT results in increased expression of APP protein CTD PMID:35946953 DDT multiple interactions ISO RGD:736021 6480464 DDT results in increased expression of and results in increased cleavage of APP protein mutant form more ... CTD PMID:25720399 , PMID:35946953 decabromodiphenyl ether increases expression EXP 6480464 decabromobiphenyl ether results in increased expression of APP mRNA CTD PMID:32679240 decabromodiphenyl ether increases secretion ISO RGD:736021 6480464 decabromobiphenyl ether results in increased secretion of APP protein modified form CTD PMID:22485137 demethoxycurcumin decreases secretion ISO RGD:736021 6480464 demethoxycurcumin results in decreased secretion of APP protein CTD PMID:19715544 demethoxycurcumin multiple interactions ISO RGD:736021 6480464 demethoxycurcumin inhibits the reaction [APP protein binds to APP protein] CTD PMID:19715544 desferrioxamine B affects binding ISO RGD:736021 6480464 Deferoxamine binds to APP 5' UTR CTD PMID:15681799 desferrioxamine B multiple interactions ISO RGD:736021 6480464 [Deferoxamine binds to APP 5' UTR] which results in decreased expression of APP protein more ... CTD PMID:15681799 , PMID:17964426 dexamethasone multiple interactions EXP 6480464 [APP protein alternative form co-treated with Dexamethasone] results in decreased expression of ADAM10 mRNA more ... CTD PMID:22484447 dextran sulfate multiple interactions ISO RGD:736022 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of APP mRNA CTD PMID:29950665 diarsenic trioxide increases expression ISO RGD:736021 6480464 Arsenic Trioxide results in increased expression of APP mRNA CTD PMID:20458559 dichlorvos increases secretion ISO RGD:736021 6480464 Dichlorvos results in increased secretion of APP protein alternative form CTD PMID:11526466 dichlorvos increases secretion EXP 6480464 Dichlorvos results in increased secretion of APP protein modified form CTD PMID:7605915 , PMID:8624119 Didymin multiple interactions ISO RGD:736021 6480464 didymin inhibits the reaction [APP protein alternative form results in increased expression of BACE1 protein] CTD PMID:31194956 dieldrin affects expression EXP 6480464 Dieldrin affects the expression of APP mRNA CTD PMID:22546817 diethyldithiocarbamic acid multiple interactions ISO RGD:736021 6480464 Ditiocarb inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of APP mRNA], Ditiocarb inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of APP protein] CTD PMID:28242320 dihydrogen multiple interactions ISO RGD:736021 6480464 [Hydrogen co-treated with APP protein] results in increased expression of CAT protein more ... CTD PMID:26271894 dimercaprol multiple interactions ISO RGD:736021 6480464 [Dimercaprol binds to APP 5' UTR] which results in decreased expression of APP protein, [Dimercaprol binds to APP 5' UTR] which results in decreased secretion of APP protein modified form CTD PMID:15681799 dimercaprol affects binding ISO RGD:736021 6480464 Dimercaprol binds to APP 5' UTR CTD PMID:15681799 dimethylarsinic acid multiple interactions ISO RGD:736021 6480464 Cacodylic Acid results in increased cleavage of and affects the secretion of APP protein mutant form, Cacodylic Acid results in increased expression of and affects the localization of APP protein mutant form CTD PMID:21440049 dimethylarsinic acid increases expression ISO RGD:736022 6480464 Cacodylic Acid results in increased expression of APP protein CTD PMID:21440049 diminazene diaceturate affects expression ISO RGD:736022 6480464 diminazene aceturate affects the expression of APP protein alternative form CTD PMID:31982938 diprotium multiple interactions ISO RGD:736021 6480464 [Hydrogen co-treated with APP protein] results in increased expression of CAT protein more ... CTD PMID:26271894 disodium selenite decreases expression ISO RGD:736022 6480464 Sodium Selenite results in decreased expression of APP mRNA CTD PMID:23274088 disulfiram multiple interactions ISO RGD:736021 6480464 [Disulfiram binds to Copper] which results in increased expression of APP mRNA CTD PMID:24690739 diuron decreases expression EXP 6480464 Diuron results in decreased expression of APP mRNA CTD PMID:21551480 dizocilpine maleate multiple interactions EXP 6480464 Dizocilpine Maleate inhibits the reaction [Pentylenetetrazole results in increased expression of APP mRNA] CTD PMID:9720974 donepezil hydrochloride multiple interactions ISO RGD:736022 6480464 Donepezil inhibits the reaction [APP protein modified form affects the localization of RELA protein] more ... CTD PMID:24189446 , PMID:30481507 donepezil hydrochloride increases abundance ISO RGD:736022 6480464 Donepezil results in increased abundance of APP protein CTD PMID:18061284 donepezil hydrochloride multiple interactions EXP 6480464 Donepezil inhibits the reaction [[Dietary Fats co-treated with Cholesterol more ... CTD PMID:24189446 , PMID:28734741 donepezil hydrochloride decreases response to substance EXP 6480464 Donepezil results in decreased susceptibility to APP protein CTD PMID:18571635 dorsomorphin multiple interactions ISO RGD:736021 6480464 dorsomorphin inhibits the reaction [Hydrogen inhibits the reaction [APP protein results in decreased expression of FOXO3 protein]] more ... CTD PMID:20080969 , PMID:26271894 doxorubicin affects response to substance ISO RGD:736021 6480464 APP protein affects the susceptibility to Doxorubicin CTD PMID:17608641 doxorubicin decreases expression ISO RGD:736021 6480464 Doxorubicin results in decreased expression of APP mRNA CTD PMID:29803840 doxorubicin multiple interactions ISO RGD:736021 6480464 TP53 protein affects the reaction [APP protein affects the susceptibility to Doxorubicin] CTD PMID:17608641 DPCPX multiple interactions EXP 6480464 1, 3-dipropyl-8-cyclopentylxanthine inhibits the reaction [cordycepin inhibits the reaction [APP protein modified form results in increased activity of ACHE protein]] CTD PMID:30031108 duvoglustat decreases response to substance ISO RGD:736022 6480464 1-Deoxynojirimycin results in decreased susceptibility to APP protein CTD PMID:19028522 edaravone multiple interactions EXP 6480464 Edaravone inhibits the reaction [APP protein modified form results in decreased expression of BCL2 mRNA] more ... CTD PMID:26111763 elemental selenium decreases expression ISO RGD:736021 6480464 Selenium results in decreased expression of APP mRNA CTD PMID:19244175 enzalutamide affects expression ISO RGD:736021 6480464 enzalutamide affects the expression of APP mRNA CTD PMID:30940724 ethanol increases expression ISO RGD:736022 6480464 Ethanol results in increased expression of APP mRNA CTD PMID:30319688 ethanol multiple interactions ISO RGD:736022 6480464 Ethanol affects the expression of and affects the splicing of APP mRNA CTD PMID:30319688 ethosuximide multiple interactions EXP 6480464 Ethosuximide inhibits the reaction [APP protein modified form results in decreased expression of APC mRNA] more ... CTD PMID:26420483 ethylenediaminetetraacetic acid multiple interactions ISO RGD:736021 6480464 Edetic Acid inhibits the reaction [[[[APP protein modified form binds to Copper] which co-treated with Ascorbic Acid] results in increased oxidation of phosphatidylcholine hydroperoxide] which results in increased chemical synthesis of 4-hydroxy-2-nonenal], Edetic Acid inhibits the reaction [[[[APP protein modified form binds to Copper] which co-treated with Ascorbic Acid] results in increased oxidation of Phosphatidylcholines] which results in increased chemical synthesis of phosphatidylcholine hydroperoxide] CTD PMID:17964426 farrerol multiple interactions EXP 6480464 farrerol inhibits the reaction [APP protein binds to APP protein] CTD PMID:17323972 fenofibrate multiple interactions ISO RGD:736021 6480464 Fenofibrate affects the reaction [PSEN1 protein affects the cleavage of APP protein] CTD PMID:17962197 ferroheme b multiple interactions ISO RGD:736021 6480464 [Hydrogen Peroxide co-treated with Sodium Nitrite] promotes the reaction [APP protein modified form binds to Heme], Hydrogen Peroxide promotes the reaction [APP protein modified form binds to Heme] CTD PMID:25211009 ferroheme b affects binding ISO RGD:736021 6480464 APP protein modified form binds to Heme CTD PMID:25211009 finasteride increases expression EXP 6480464 Finasteride results in increased expression of APP mRNA CTD PMID:24136188 fipronil increases expression EXP 6480464 fipronil results in increased expression of APP mRNA CTD PMID:23962444 fisetin multiple interactions ISO RGD:736022 6480464 fisetin inhibits the reaction [Lead results in increased expression of APP protein] CTD PMID:31539617 flurbiprofen affects cleavage ISO RGD:736022 6480464 Flurbiprofen affects the cleavage of APP protein CTD PMID:14690522 flurbiprofen decreases secretion ISO RGD:736021 6480464 Flurbiprofen results in decreased secretion of APP protein CTD PMID:17292621 , PMID:19659691 flurbiprofen multiple interactions ISO RGD:736021 6480464 alitretinoin inhibits the reaction [Flurbiprofen results in decreased secretion of APP protein] more ... CTD PMID:19659691 flurbiprofen multiple interactions EXP 6480464 Flurbiprofen inhibits the reaction [APP protein results in increased uptake of Calcium] CTD PMID:18648507 flutamide decreases expression EXP 6480464 Flutamide results in decreased expression of APP mRNA CTD PMID:24793618 flutamide multiple interactions EXP 6480464 Flutamide inhibits the reaction [Trenbolone Acetate analog results in increased expression of APP protein modified form] CTD PMID:25461682 folic acid multiple interactions ISO RGD:736022 6480464 [1 more ... CTD PMID:20938992 more ... folic acid multiple interactions ISO RGD:736021 6480464 APP protein affects the reaction [Folic Acid affects the expression of DNMT1 mRNA] more ... CTD PMID:26492244 folic acid decreases expression ISO RGD:736021 6480464 Folic Acid results in decreased expression of APP protein CTD PMID:26492244 folpet decreases expression ISO RGD:736022 6480464 folpet results in decreased expression of APP mRNA CTD PMID:31558096 fonofos increases methylation ISO RGD:736021 6480464 Fonofos results in increased methylation of APP promoter CTD PMID:22847954 fulvestrant multiple interactions EXP 6480464 fulvestrant inhibits the reaction [Trenbolone Acetate analog results in increased expression of APP protein modified form] CTD PMID:25461682 fulvestrant multiple interactions ISO RGD:736021 6480464 [bisphenol A co-treated with Fulvestrant] results in decreased methylation of APP gene, [bisphenol F co-treated with Fulvestrant] results in decreased methylation of APP gene CTD PMID:31601247 fumonisin B1 increases expression ISO RGD:736022 6480464 fumonisin B1 results in increased expression of APP mRNA CTD PMID:16221962 furan increases expression EXP 6480464 furan results in increased expression of APP mRNA CTD PMID:25539665 galactose multiple interactions ISO RGD:736022 6480464 [Galactose co-treated with Aluminum Chloride] results in decreased expression of APP protein more ... CTD PMID:35537655 galanthamine multiple interactions ISO RGD:736022 6480464 Galantamine inhibits the reaction [APP protein modified form results in decreased expression of CHRNA7 protein], methyllycaconitine inhibits the reaction [Galantamine inhibits the reaction [APP protein modified form results in decreased expression of CHRNA7 protein]] CTD PMID:25881725 galanthamine Trifluoroacetic acid multiple interactions ISO RGD:736022 6480464 Galantamine inhibits the reaction [APP protein modified form results in decreased expression of CHRNA7 protein], methyllycaconitine inhibits the reaction [Galantamine inhibits the reaction [APP protein modified form results in decreased expression of CHRNA7 protein]] CTD PMID:25881725 gallic acid multiple interactions ISO RGD:736021 6480464 Gallic Acid inhibits the reaction [2 more ... CTD PMID:22129351 gamma-tocopherol decreases abundance EXP 6480464 APP protein modified form results in decreased abundance of Tocopherols CTD PMID:25654502 gamma-tocopherol multiple interactions EXP 6480464 resveratrol inhibits the reaction [APP protein modified form results in decreased abundance of Tocopherols] CTD PMID:25654502 genistein increases expression ISO RGD:736022 6480464 Genistein results in increased expression of APP mRNA CTD PMID:32186404 gentamycin increases expression EXP 6480464 Gentamicins results in increased expression of APP mRNA CTD PMID:22061828 ginkgolide B multiple interactions ISO RGD:736021 6480464 ginkgolide B inhibits the reaction [APP protein results in increased abundance of Reactive Oxygen Species] more ... CTD PMID:19464278 Ginkgolide C multiple interactions ISO RGD:736021 6480464 1H-(1 more ... CTD PMID:18001288 ginsenoside Rd multiple interactions EXP 6480464 ginsenoside Rd inhibits the reaction [APP protein modified form results in decreased expression of BCL2 mRNA] more ... CTD PMID:26111763 ginsenoside Rg1 multiple interactions EXP 6480464 ginsenoside Rg1 inhibits the reaction [[APP protein alternative form co-treated with Dexamethasone] results in decreased expression of ADAM10 mRNA] more ... CTD PMID:22484447 ginsenoside Rg2 multiple interactions EXP 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ginsenoside Rg2 inhibits the reaction [APP protein modified form results in decreased phosphorylation of AKT1 protein]] more ... CTD PMID:28756148 glutathione multiple interactions EXP 6480464 resveratrol inhibits the reaction [APP protein modified form results in decreased abundance of Glutathione] CTD PMID:25654502 glutathione decreases abundance ISO RGD:736022 6480464 APP protein modified form results in decreased abundance of Glutathione CTD PMID:29545167 glutathione multiple interactions ISO RGD:736022 6480464 vitexin inhibits the reaction [APP protein modified form results in decreased abundance of Glutathione] CTD PMID:29545167 glutathione decreases abundance EXP 6480464 APP protein modified form results in decreased abundance of Glutathione CTD PMID:25654502 glycine betaine multiple interactions ISO RGD:736022 6480464 Betaine inhibits the reaction [Azacitidine results in decreased methylation of APP promoter] more ... CTD PMID:19635394 glycitin multiple interactions EXP 6480464 glycitin inhibits the reaction [APP protein binds to APP protein] CTD PMID:17323972 glyphosate increases expression ISO RGD:736021 6480464 glyphosate results in increased expression of APP mRNA CTD PMID:31874349 Goe 6976 multiple interactions ISO RGD:736021 6480464 Go 6976 inhibits the reaction [Phorbol 12 more ... CTD PMID:19476501 GTP increases secretion ISO RGD:736021 6480464 Guanosine Triphosphate results in increased secretion of APP protein modified form CTD PMID:22906069 GW 501516 multiple interactions ISO RGD:736021 6480464 GW 501516 inhibits the reaction [APP gene mutant form results in decreased expression of GCH1 protein] more ... CTD PMID:22886847 heme b affects binding ISO RGD:736021 6480464 APP protein modified form binds to Heme CTD PMID:25211009 heme b multiple interactions ISO RGD:736021 6480464 [Hydrogen Peroxide co-treated with Sodium Nitrite] promotes the reaction [APP protein modified form binds to Heme], Hydrogen Peroxide promotes the reaction [APP protein modified form binds to Heme] CTD PMID:25211009 heparin multiple interactions ISO RGD:736021 6480464 Copper promotes the reaction [Heparin binds to APP protein], Zinc promotes the reaction [Heparin binds to APP protein] CTD PMID:25835329 heroin decreases expression ISO RGD:736021 6480464 Heroin results in decreased expression of APP mRNA CTD PMID:16710320 hexaconazole increases expression ISO RGD:736022 6480464 hexaconazole results in increased expression of APP mRNA CTD PMID:22045034 hexadecanoic acid multiple interactions ISO RGD:736021 6480464 [Palmitic Acid co-treated with Arsenic] affects the expression of APP mRNA CTD PMID:33736254 hexadecanoic acid affects expression ISO RGD:736021 6480464 Palmitic Acid affects the expression of APP mRNA CTD PMID:33736254 homocysteine increases abundance ISO RGD:736022 6480464 APP protein results in increased abundance of Homocysteine CTD PMID:16837103 hydrogen peroxide multiple interactions ISO RGD:736021 6480464 4-((alpha-L-rhamnosyloxy)benzyl)isothiocyanate inhibits the reaction [Hydrogen Peroxide results in increased expression of APP mRNA] more ... CTD PMID:15699049 more ... hydrogen peroxide decreases secretion ISO RGD:736021 6480464 Hydrogen Peroxide results in decreased secretion of APP protein modified form CTD PMID:22906069 hydrogen peroxide affects expression ISO RGD:736021 6480464 Hydrogen Peroxide affects the expression of APP mRNA, Hydrogen Peroxide affects the expression of APP protein CTD PMID:21179406 hydrogen peroxide increases expression ISO RGD:736021 6480464 Hydrogen Peroxide results in increased expression of APP mRNA, Hydrogen Peroxide results in increased expression of APP protein alternative form CTD PMID:12419474 more ... ibuprofen affects cleavage ISO RGD:736021 6480464 Ibuprofen affects the cleavage of APP protein CTD PMID:11700559 , PMID:12777371 ibuprofen multiple interactions EXP 6480464 Ibuprofen inhibits the reaction [APP protein results in increased uptake of Calcium] CTD PMID:18648507 ibuprofen multiple interactions ISO RGD:736022 6480464 Ibuprofen inhibits the reaction [[APP protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide], Ibuprofen inhibits the reaction [[APP protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA] CTD PMID:11080519 ibuprofen decreases expression ISO RGD:736021 6480464 Ibuprofen results in decreased expression of APP protein mutant form CTD PMID:15817521 ibuprofen multiple interactions ISO RGD:736021 6480464 Ibuprofen inhibits the reaction [[IFNG protein co-treated with IL1B protein] results in increased metabolism of and results in increased secretion of APP protein alternative form], Ibuprofen inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased metabolism of and results in increased secretion of APP protein alternative form] CTD PMID:14586007 icariin multiple interactions EXP 6480464 icariin inhibits the reaction [APP protein alternative form results in decreased expression of SOD2 mRNA], icariin inhibits the reaction [APP protein alternative form results in increased expression of BACE1 mRNA] CTD PMID:19782061 idarubicin increases response to substance ISO RGD:736022 6480464 APP gene mutant form results in increased susceptibility to Idarubicin CTD PMID:25926793 indole-3-methanol affects expression EXP 6480464 indole-3-carbinol affects the expression of APP mRNA CTD PMID:21396975 indometacin multiple interactions ISO RGD:736021 6480464 Indomethacin inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased metabolism of and results in increased secretion of APP protein alternative form], Indomethacin inhibits the reaction [APP protein alternative form results in increased expression of IL6 protein] CTD PMID:14586007 , PMID:16111494 indometacin decreases expression ISO RGD:736022 6480464 Indomethacin results in decreased expression of APP protein alternative form CTD PMID:15579461 , PMID:17627676 indometacin multiple interactions EXP 6480464 Indomethacin inhibits the reaction [APP protein results in increased uptake of Calcium] CTD PMID:18648507 indometacin multiple interactions ISO RGD:736022 6480464 Indomethacin inhibits the reaction [[APP protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide], Indomethacin inhibits the reaction [[APP protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA] CTD PMID:11080519 indometacin affects cleavage ISO RGD:736021 6480464 Indomethacin affects the cleavage of APP protein CTD PMID:11700559 inulin multiple interactions ISO RGD:736022 6480464 [perfluorooctane sulfonic acid co-treated with Inulin] results in decreased expression of APP mRNA CTD PMID:36331819 iron atom increases uptake ISO RGD:736021 6480464 Iron results in increased uptake of APP protein CTD PMID:15993987 iron atom increases expression ISO RGD:736021 6480464 Iron results in increased expression of APP mRNA CTD PMID:16308480 iron(0) increases expression ISO RGD:736021 6480464 Iron results in increased expression of APP mRNA CTD PMID:16308480 iron(0) increases uptake ISO RGD:736021 6480464 Iron results in increased uptake of APP protein CTD PMID:15993987 isoflurane multiple interactions ISO RGD:736021 6480464 APP protein promotes the reaction [Isoflurane results in increased cleavage of and results in increased activity of CASP3 protein] more ... CTD PMID:17287498 isoniazide increases expression ISO RGD:736021 6480464 Isoniazid results in increased expression of APP mRNA CTD PMID:30008028 ivermectin decreases expression ISO RGD:736021 6480464 Ivermectin results in decreased expression of APP protein CTD PMID:32959892 kaempferol multiple interactions EXP 6480464 kaempferol inhibits the reaction [APP protein binds to APP protein] CTD PMID:17323972 kaempferol 3-O-beta-D-glucoside multiple interactions ISO RGD:736022 6480464 astragalin inhibits the reaction [[Galactose co-treated with Aluminum Chloride] results in decreased expression of APP protein] CTD PMID:35537655 ketamine multiple interactions ISO RGD:736022 6480464 [Ketamine results in increased cleavage of APP protein] which results in increased abundance of amyloid beta-protein (1-40) more ... CTD PMID:35378374 ketamine multiple interactions ISO RGD:736021 6480464 Ketamine results in decreased expression of and results in increased cleavage of APP protein, Monensin inhibits the reaction [Ketamine results in decreased expression of and results in increased cleavage of APP protein] CTD PMID:35378374 ketamine increases expression ISO RGD:736021 6480464 Ketamine results in increased expression of APP mRNA CTD PMID:35378374 kojic acid increases expression ISO RGD:736021 6480464 kojic acid results in increased expression of APP mRNA CTD PMID:16595896 KT 5720 multiple interactions ISO RGD:736022 6480464 KT 5720 inhibits the reaction [cilostazol inhibits the reaction [APP protein results in decreased expression of and results in decreased activity of SIRT1 protein]] CTD PMID:24254769 KT 5823 multiple interactions ISO RGD:736021 6480464 KT 5823 inhibits the reaction [Ginkgo biloba extract inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein]] more ... CTD PMID:18001288 L-ascorbic acid increases oxidation ISO RGD:736021 6480464 APP protein modified form results in increased oxidation of Ascorbic Acid CTD PMID:17964426 L-ascorbic acid decreases abundance EXP 6480464 APP protein modified form results in decreased abundance of Ascorbic Acid CTD PMID:25654502 L-ascorbic acid multiple interactions EXP 6480464 Ascorbic Acid inhibits the reaction [APP protein modified form results in increased abundance of Reactive Oxygen Species], resveratrol inhibits the reaction [APP protein modified form results in decreased abundance of Ascorbic Acid] CTD PMID:15030205 , PMID:25654502 L-ascorbic acid multiple interactions ISO RGD:736021 6480464 [[[APP protein modified form binds to Copper] which co-treated with Ascorbic Acid] results in increased oxidation of phosphatidylcholine hydroperoxide] which results in increased chemical synthesis of 4-hydroxy-2-nonenal more ... CTD PMID:17964426 , PMID:24276282 L-erythro-7,8-dihydrobiopterin increases abundance ISO RGD:736021 6480464 APP gene mutant form results in increased abundance of 7, 8-dihydrobiopterin CTD PMID:22886847 L-erythro-7,8-dihydrobiopterin multiple interactions ISO RGD:736021 6480464 GW 501516 inhibits the reaction [APP gene mutant form results in increased abundance of 7, 8-dihydrobiopterin] CTD PMID:22886847 L-methionine multiple interactions ISO RGD:736022 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of APP mRNA CTD PMID:20938992 L-serine multiple interactions EXP 6480464 [LAMC1 protein modified form co-treated with ANGPT1 protein co-treated with Serine] inhibits the reaction [beta-N-methylamino-L-alanine results in increased expression of APP protein], Serine inhibits the reaction [beta-N-methylamino-L-alanine results in increased expression of APP protein] CTD PMID:30476904 lactacystin multiple interactions ISO RGD:736021 6480464 lactacystin inhibits the reaction [resveratrol results in decreased secretion of APP protein] CTD PMID:16162502 lead diacetate increases expression ISO RGD:736022 6480464 lead acetate results in increased expression of APP mRNA more ... CTD PMID:22279679 , PMID:23867794 lead diacetate affects expression EXP 6480464 lead acetate affects the expression of APP protein CTD PMID:36539177 lead diacetate multiple interactions ISO RGD:736022 6480464 [lead acetate results in increased abundance of Lead] which results in increased expression of APP mRNA, [lead acetate results in increased abundance of Lead] which results in increased expression of APP protein CTD PMID:31730887 lead diacetate multiple interactions EXP 6480464 Proanthocyanidins inhibits the reaction [lead acetate results in increased expression of APP protein modified form] CTD PMID:25088297 lead diacetate increases expression ISO RGD:736021 6480464 lead acetate results in increased expression of APP protein modified form CTD PMID:24462621 lead diacetate multiple interactions ISO RGD:736021 6480464 [[lead acetate results in increased abundance of Lead] which co-treated with APP protein modified form] results in decreased expression of SYP protein more ... CTD PMID:24462621 , PMID:31843630 lead diacetate decreases methylation EXP 6480464 lead acetate results in decreased methylation of APP promoter CTD PMID:21117136 , PMID:22764079 lead diacetate increases expression EXP 6480464 lead acetate results in increased expression of APP mRNA more ... CTD PMID:21117136 more ... lead tetraacetate decreases expression ISO RGD:736022 6480464 lead tetraacetate results in decreased expression of APP mRNA CTD PMID:20865013 lead(0) affects abundance EXP 6480464 Lead affects the abundance of APP mRNA, Lead affects the abundance of APP protein CTD PMID:16230335 lead(0) increases expression ISO RGD:736022 6480464 Lead results in increased expression of APP protein CTD PMID:31539617 lead(0) multiple interactions ISO RGD:736022 6480464 [lead acetate results in increased abundance of Lead] which results in increased expression of APP mRNA more ... CTD PMID:31539617 , PMID:31730887 lead(0) affects splicing ISO RGD:736021 6480464 Lead affects the splicing of APP mRNA CTD PMID:28903495 lead(0) affects expression ISO RGD:736021 6480464 Lead affects the expression of APP mRNA CTD PMID:28903495 lead(0) increases secretion ISO RGD:736021 6480464 Lead results in increased secretion of APP protein alternative form CTD PMID:25673500 lead(0) increases expression EXP 6480464 Lead results in increased expression of APP protein alternative form CTD PMID:25288670 lead(0) increases localization EXP 6480464 Lead results in increased localization of APP protein CTD PMID:20488202 lead(0) multiple interactions ISO RGD:736021 6480464 [[lead acetate results in increased abundance of Lead] which co-treated with APP protein modified form] results in decreased expression of SYP protein more ... CTD PMID:22610977 , PMID:31843630 lead(0) increases expression ISO RGD:736021 6480464 Lead results in increased expression of APP mRNA, Lead results in increased expression of APP protein CTD PMID:19921347 more ... lead(0) decreases expression ISO RGD:736021 6480464 Lead results in decreased expression of APP protein modified form CTD PMID:22313790 lead(0) multiple interactions EXP 6480464 [Arsenic co-treated with Cadmium co-treated with Lead] promotes the reaction [BACE1 protein results in increased metabolism of APP protein] more ... CTD PMID:16230335 more ... lead(2+) multiple interactions ISO RGD:736021 6480464 [[lead acetate results in increased abundance of Lead] which co-treated with APP protein modified form] results in decreased expression of SYP protein more ... CTD PMID:22610977 , PMID:31843630 lead(2+) increases expression ISO RGD:736022 6480464 Lead results in increased expression of APP protein CTD PMID:31539617 lead(2+) multiple interactions ISO RGD:736022 6480464 [lead acetate results in increased abundance of Lead] which results in increased expression of APP mRNA more ... CTD PMID:31539617 , PMID:31730887 lead(2+) affects splicing ISO RGD:736021 6480464 Lead affects the splicing of APP mRNA CTD PMID:28903495 lead(2+) affects expression ISO RGD:736021 6480464 Lead affects the expression of APP mRNA CTD PMID:28903495 lead(2+) increases secretion ISO RGD:736021 6480464 Lead results in increased secretion of APP protein alternative form CTD PMID:25673500 lead(2+) increases expression EXP 6480464 Lead results in increased expression of APP protein alternative form CTD PMID:25288670 lead(2+) decreases expression ISO RGD:736021 6480464 Lead results in decreased expression of APP protein modified form CTD PMID:22313790 lead(2+) increases localization EXP 6480464 Lead results in increased localization of APP protein CTD PMID:20488202 lead(2+) multiple interactions EXP 6480464 [Arsenic co-treated with Cadmium co-treated with Lead] promotes the reaction [BACE1 protein results in increased metabolism of APP protein] more ... CTD PMID:16230335 more ... lead(2+) affects abundance EXP 6480464 Lead affects the abundance of APP mRNA, Lead affects the abundance of APP protein CTD PMID:16230335 lead(2+) increases expression ISO RGD:736021 6480464 Lead results in increased expression of APP mRNA, Lead results in increased expression of APP protein CTD PMID:19921347 more ... lipopolysaccharide increases expression ISO RGD:736022 6480464 Lipopolysaccharides results in increased expression of APP mRNA CTD PMID:15919760 lipopolysaccharide multiple interactions ISO RGD:736021 6480464 [Lipopolysaccharides co-treated with IFNG protein] results in increased expression of APP mRNA more ... CTD PMID:28242320 , PMID:35877022 lipopolysaccharide multiple interactions EXP 6480464 APP protein modified form inhibits the reaction [Lipopolysaccharides results in increased activity of CEBPD protein] more ... CTD PMID:15223066 , PMID:18405661 lithium atom multiple interactions ISO RGD:736022 6480464 Lithium inhibits the reaction [APP protein binds to APP protein] CTD PMID:19621015 lithium atom multiple interactions EXP 6480464 Lithium inhibits the reaction [APP protein alternative form results in decreased expression of BCL2 protein] CTD PMID:10762662 lithium chloride multiple interactions ISO RGD:736021 6480464 Lithium Chloride inhibits the reaction [Copper affects the localization of APP protein] CTD PMID:24610780 lithium hydride multiple interactions ISO RGD:736022 6480464 Lithium inhibits the reaction [APP protein binds to APP protein] CTD PMID:19621015 lithium hydride multiple interactions EXP 6480464 Lithium inhibits the reaction [APP protein alternative form results in decreased expression of BCL2 protein] CTD PMID:10762662 lovastatin multiple interactions EXP 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Lovastatin results in increased secretion of APP protein modified form] more ... CTD PMID:19741129 , PMID:29341888 lovastatin multiple interactions ISO RGD:736021 6480464 [APP protein co-treated with Lovastatin] results in increased secretion of APP protein more ... CTD PMID:29341888 lovastatin increases cleavage ISO RGD:736021 6480464 Lovastatin results in increased cleavage of APP protein CTD PMID:29341888 lovastatin increases cleavage EXP 6480464 Lovastatin results in increased cleavage of APP protein CTD PMID:29341888 lovastatin increases secretion EXP 6480464 Lovastatin results in increased secretion of APP protein, Lovastatin results in increased secretion of APP protein modified form CTD PMID:19741129 , PMID:29341888 LY294002 multiple interactions EXP 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [coenzyme Q10 results in decreased susceptibility to APP protein] more ... CTD PMID:19741129 more ... LY294002 multiple interactions ISO RGD:736021 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Clioquinol co-treated with Copper] results in decreased expression of APP protein alternative form] CTD PMID:16648635 malonaldehyde multiple interactions ISO RGD:736022 6480464 vitexin inhibits the reaction [APP protein modified form results in increased abundance of Malondialdehyde] CTD PMID:29545167 malonaldehyde increases abundance ISO RGD:736022 6480464 APP protein modified form results in increased abundance of Malondialdehyde CTD PMID:29545167 manganese atom increases expression ISO RGD:736021 6480464 Manganese results in increased expression of APP mRNA CTD PMID:18583042 manganese(0) increases expression ISO RGD:736021 6480464 Manganese results in increased expression of APP mRNA CTD PMID:18583042 Mecamylamine multiple interactions ISO RGD:736021 6480464 Mecamylamine inhibits the reaction [Nicotine inhibits the reaction [Copper results in increased expression of APP protein]] CTD PMID:16627626 melatonin multiple interactions ISO RGD:736021 6480464 Melatonin affects the reaction [APP protein binds to APP protein], Melatonin inhibits the reaction [Mercuric Chloride results in increased secretion of APP protein modified form] CTD PMID:10617124 , PMID:18537544 melatonin multiple interactions EXP 6480464 Melatonin inhibits the reaction [[Aluminum Chloride results in increased expression of APP protein] which results in increased abundance of amyloid beta-protein (1-42)], Melatonin inhibits the reaction [Aluminum Chloride results in increased expression of APP protein] CTD PMID:33130240 melatonin decreases expression ISO RGD:736022 6480464 Melatonin analog results in decreased expression of APP protein, Melatonin results in decreased expression of APP protein CTD PMID:18231852 meloxicam multiple interactions ISO RGD:736022 6480464 meloxicam inhibits the reaction [Aluminum results in increased expression of APP protein] CTD PMID:16928369 memantine multiple interactions EXP 6480464 Memantine inhibits the reaction [Streptozocin results in increased expression of APP protein modified form] CTD PMID:21290839 mepanipyrim multiple interactions ISO RGD:736021 6480464 [APP gene mutant form results in increased expression of APP protein modified form] which results in increased susceptibility to mepanipyrim more ... CTD PMID:31939705 mercury atom multiple interactions ISO RGD:736021 6480464 Estradiol inhibits the reaction [Mercury results in increased secretion of APP protein modified form] CTD PMID:12182891 mercury atom increases secretion ISO RGD:736021 6480464 Mercury results in increased secretion of APP protein alternative form, Mercury results in increased secretion of APP protein modified form CTD PMID:12182891 , PMID:25673500 mercury dichloride multiple interactions ISO RGD:736021 6480464 Melatonin inhibits the reaction [Mercuric Chloride results in increased secretion of APP protein modified form] CTD PMID:10617124 mercury dichloride increases secretion ISO RGD:736021 6480464 Mercuric Chloride results in increased secretion of APP protein modified form CTD PMID:10617124 mercury(0) multiple interactions ISO RGD:736021 6480464 Estradiol inhibits the reaction [Mercury results in increased secretion of APP protein modified form] CTD PMID:12182891 mercury(0) increases secretion ISO RGD:736021 6480464 Mercury results in increased secretion of APP protein alternative form, Mercury results in increased secretion of APP protein modified form CTD PMID:12182891 , PMID:25673500 methamphetamine multiple interactions EXP 6480464 Methamphetamine results in increased expression of and results in increased cleavage of APP protein CTD PMID:30367931 methamphetamine increases secretion EXP 6480464 Methamphetamine results in increased secretion of APP protein CTD PMID:30367931 methamphetamine increases expression ISO RGD:736021 6480464 Methamphetamine results in increased expression of APP protein CTD PMID:31270305 methamphetamine multiple interactions ISO RGD:736021 6480464 Rosiglitazone inhibits the reaction [Methamphetamine results in increased expression of APP protein] CTD PMID:31270305 methapyrilene increases expression EXP 6480464 Methapyrilene results in increased expression of APP mRNA CTD PMID:22484513 methidathion increases expression ISO RGD:736022 6480464 methidathion results in increased expression of APP mRNA CTD PMID:34813904 methotrexate decreases expression ISO RGD:736021 6480464 Methotrexate results in decreased expression of APP mRNA CTD PMID:17400583 methotrexate increases expression ISO RGD:736021 6480464 Methotrexate results in increased expression of APP mRNA CTD PMID:21678067 methyllycaconitine multiple interactions ISO RGD:736022 6480464 methyllycaconitine inhibits the reaction [Galantamine inhibits the reaction [APP protein modified form results in decreased expression of CHRNA7 protein]] more ... CTD PMID:25881725 methyllycaconitine multiple interactions ISO RGD:736021 6480464 [APP protein co-treated with methyllycaconitine] results in decreased secretion of APP protein CTD PMID:29341888 methyllycaconitine decreases secretion EXP 6480464 methyllycaconitine results in decreased secretion of APP protein CTD PMID:29341888 Methysticin multiple interactions ISO RGD:736022 6480464 methysticin inhibits the reaction [[PSEN1 protein co-treated with APP protein] results in increased secretion of IL17A protein], methysticin inhibits the reaction [[PSEN1 protein co-treated with APP protein] results in increased secretion of TNF protein] CTD PMID:28448946 minocycline multiple interactions ISO RGD:736022 6480464 Minocycline inhibits the reaction [APP gene mutant form results in increased phosphorylation of EIF2S1 protein] CTD PMID:17406652 minocycline multiple interactions EXP 6480464 Minocycline inhibits the reaction [APP protein alternative form results in increased activity of CASP12 protein] more ... CTD PMID:17406652 miquelianin decreases expression ISO RGD:736021 6480464 quercetin 3-O-glucuronide results in decreased expression of APP protein CTD PMID:23097297 miquelianin multiple interactions ISO RGD:736021 6480464 quercetin 3-O-glucuronide inhibits the reaction [APP protein binds to APP protein modified form] CTD PMID:23097297 mitomycin C increases expression ISO RGD:736021 6480464 Mitomycin results in increased expression of APP mRNA CTD PMID:12760830 monensin A multiple interactions ISO RGD:736021 6480464 Monensin inhibits the reaction [Ketamine results in decreased expression of and results in increased cleavage of APP protein] CTD PMID:35378374 monensin A multiple interactions ISO RGD:736022 6480464 Monensin inhibits the reaction [[Ketamine results in increased cleavage of APP protein] which results in increased abundance of amyloid beta-protein (1-40)], Monensin inhibits the reaction [[Ketamine results in increased cleavage of APP protein] which results in increased abundance of amyloid beta-protein (1-42)] CTD PMID:35378374 morin multiple interactions ISO RGD:736021 6480464 morin affects the reaction [APP protein binds to APP protein] CTD PMID:18537544 N,N-diethyl-m-toluamide multiple interactions EXP 6480464 [Permethrin co-treated with DEET] results in decreased methylation of APP gene CTD PMID:33148267 N-acetyl-L-cysteine multiple interactions ISO RGD:736021 6480464 Acetylcysteine inhibits the reaction [APP protein affects the localization of RELA protein] more ... CTD PMID:12684028 , PMID:28004443 N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal multiple interactions ISO RGD:736022 6480464 benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [APP protein modified form results in decreased expression of and results in decreased activity of TERT protein] CTD PMID:21520056 N-methyl-N'-nitro-N-nitrosoguanidine multiple interactions ISO RGD:736022 6480464 [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in decreased expression of APP mRNA more ... CTD PMID:19840844 N-nitrosodiethylamine increases expression EXP 6480464 Diethylnitrosamine results in increased expression of APP mRNA, Diethylnitrosamine results in increased expression of APP protein CTD PMID:19542621 more ... N-nitrosodiethylamine increases expression ISO RGD:736022 6480464 Diethylnitrosamine results in increased expression of APP mRNA CTD PMID:24535843 N-nitrosodiethylamine multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of APP mRNA CTD PMID:17602206 N-nitrosodimethylamine affects expression EXP 6480464 Dimethylnitrosamine affects the expression of APP mRNA CTD PMID:25380136 neoechinulin A multiple interactions ISO RGD:736022 6480464 neoechinulin A inhibits the reaction [[APP protein binds to APP protein binds to APP protein] which affects the localization of NFKB1 protein] more ... CTD PMID:23261590 nickel atom affects binding ISO RGD:736021 6480464 Nickel binds to APP protein alternative form CTD PMID:15699049 nicotine decreases expression ISO RGD:736021 6480464 Nicotine results in decreased expression of APP mRNA, Nicotine results in decreased expression of APP protein CTD PMID:16627626 nicotine increases metabolic processing ISO RGD:736021 6480464 Nicotine results in increased metabolism of APP protein CTD PMID:29618714 nicotine multiple interactions ISO RGD:736021 6480464 [Nicotine results in increased metabolism of APP protein] which results in increased secretion of APP protein modified form more ... CTD PMID:16627626 , PMID:29618714 nicotine multiple interactions EXP 6480464 APP protein modified form inhibits the reaction [Nicotine results in increased secretion of Acetylcholine] more ... CTD PMID:16474004 nicotine decreases expression ISO RGD:736022 6480464 Nicotine results in decreased expression of APP protein alternative form CTD PMID:17135361 nimodipine multiple interactions EXP 6480464 Nimodipine inhibits the reaction [APP protein results in increased uptake of Calcium] CTD PMID:12383957 nitric oxide multiple interactions ISO RGD:736022 6480464 [APP protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide more ... CTD PMID:11080519 nitroprusside multiple interactions ISO RGD:736022 6480464 APP protein promotes the reaction [Nitroprusside results in decreased activity of CHAT protein] CTD PMID:16724269 nitroprusside decreases secretion ISO RGD:736022 6480464 Nitroprusside results in decreased secretion of APP protein alternative form CTD PMID:10691295 notoginsenoside R1 multiple interactions EXP 6480464 notoginsenoside R1 inhibits the reaction [APP protein modified form results in decreased expression of BCL2 protein] more ... CTD PMID:24975829 notoginsenoside R1 multiple interactions ISO RGD:736022 6480464 notoginsenoside R1 inhibits the reaction [[APP gene mutant form co-treated with PSEN1 gene mutant form] results in increased expression of APP protein modified form] CTD PMID:25714973 ochratoxin A increases expression ISO RGD:736021 6480464 ochratoxin A results in increased expression of APP mRNA CTD PMID:30008028 okadaic acid multiple interactions ISO RGD:736022 6480464 [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in decreased expression of APP mRNA CTD PMID:19840844 olanzapine multiple interactions EXP 6480464 olanzapine inhibits the reaction [APP protein modified form affects the activity of CAT protein], olanzapine inhibits the reaction [APP protein modified form results in increased abundance of Reactive Oxygen Species] CTD PMID:15948179 orlistat multiple interactions ISO RGD:736021 6480464 [1 more ... CTD PMID:28721267 orphenadrine affects expression EXP 6480464 Orphenadrine affects the expression of APP mRNA CTD PMID:23665939 ozone multiple interactions ISO RGD:736021 6480464 [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased expression of and results in increased oxidation of APP mRNA more ... CTD PMID:32699268 ozone multiple interactions ISO RGD:736022 6480464 [Air Pollutants results in increased abundance of Ozone] which results in decreased expression of APP mRNA CTD PMID:34911549 ozone increases expression ISO RGD:736022 6480464 Ozone results in increased expression of APP protein CTD PMID:29385576 ozone increases response to substance ISO RGD:736022 6480464 APP results in increased susceptibility to Ozone CTD PMID:26116027 p-anisidine affects localization ISO RGD:736022 6480464 4-anisidine affects the localization of APP protein CTD PMID:18949129 p-anisidine multiple interactions ISO RGD:736022 6480464 4-anisidine affects the reaction [APP protein affects the abundance of Calcium] CTD PMID:18949129 p-menthan-3-ol decreases expression ISO RGD:736021 6480464 Menthol results in decreased expression of APP mRNA CTD PMID:26760959 paracetamol increases expression ISO RGD:736021 6480464 Acetaminophen results in increased expression of APP mRNA CTD PMID:30008028 paraquat increases response to substance ISO RGD:736021 6480464 APP protein results in increased susceptibility to Paraquat CTD PMID:23827522 paraquat increases expression EXP 6480464 Paraquat results in increased expression of APP protein, Paraquat results in increased expression of APP protein alternative form CTD PMID:31715309 , PMID:32738378 paraquat increases expression ISO RGD:736021 6480464 Paraquat results in increased expression of APP mRNA, Paraquat results in increased expression of APP protein CTD PMID:27793699 paraquat multiple interactions EXP 6480464 [BDNF protein co-treated with MF63 compound co-treated with Estradiol] inhibits the reaction [Paraquat results in increased expression of APP protein alternative form] more ... CTD PMID:31715309 , PMID:32738378 paraquat multiple interactions ISO RGD:736021 6480464 Carnitine promotes the reaction [Paraquat deficiency inhibits the reaction [Paraquat promotes the reaction [APP protein binds to APP protein]]] more ... CTD PMID:27793699 , PMID:33290254 parathion increases methylation ISO RGD:736021 6480464 Parathion results in increased methylation of APP promoter CTD PMID:22847954 paroxetine multiple interactions ISO RGD:736021 6480464 [Paroxetine binds to APP 5' UTR] which results in decreased secretion of APP protein modified form CTD PMID:15681799 PCB138 multiple interactions ISO RGD:736022 6480464 [2 more ... CTD PMID:26480858 pentetrazol multiple interactions EXP 6480464 Dizocilpine Maleate inhibits the reaction [Pentylenetetrazole results in increased expression of APP mRNA] more ... CTD PMID:32653415 , PMID:9720974 pentetrazol increases expression EXP 6480464 Pentylenetetrazole results in increased expression of APP mRNA, Pentylenetetrazole results in increased expression of APP protein CTD PMID:32653415 , PMID:9720974 pentobarbital affects expression EXP 6480464 Pentobarbital affects the expression of APP mRNA CTD PMID:1306490 pentobarbital multiple interactions EXP 6480464 Pentobarbital inhibits the reaction [Pentylenetetrazole results in increased expression of APP mRNA] CTD PMID:9720974 perfluorobutanesulfonic acid increases expression ISO RGD:736021 6480464 perfluorobutanesulfonic acid results in increased expression of APP mRNA CTD PMID:33772556 perfluorooctane-1-sulfonic acid increases expression EXP 6480464 perfluorooctane sulfonic acid results in increased expression of APP protein CTD PMID:27018931 perfluorooctane-1-sulfonic acid multiple interactions ISO RGD:736022 6480464 [perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of APP mRNA more ... CTD PMID:36331819 perfluorooctane-1-sulfonic acid increases expression ISO RGD:736021 6480464 perfluorooctane sulfonic acid results in increased expression of APP mRNA CTD PMID:33772556 perfluorooctanoic acid increases expression EXP 6480464 perfluorooctanoic acid results in increased expression of APP mRNA CTD PMID:19162173 perfluorooctanoic acid increases expression ISO RGD:736021 6480464 perfluorooctanoic acid results in increased expression of APP mRNA CTD PMID:33772556 perfluorooctanoic acid decreases expression ISO RGD:736021 6480464 perfluorooctanoic acid results in decreased expression of APP protein CTD PMID:26879310 permethrin multiple interactions EXP 6480464 [Permethrin co-treated with DEET] results in decreased methylation of APP gene CTD PMID:33148267 phenobarbital increases expression EXP 6480464 Phenobarbital results in increased expression of APP mRNA CTD PMID:15093671 more ... PhIP increases expression ISO RGD:736022 6480464 2-amino-1-methyl-6-phenylimidazo(4 more ... CTD PMID:32169473 phlorizin decreases expression ISO RGD:736022 6480464 Phlorhizin results in decreased expression of APP mRNA CTD PMID:22538082 phorbol 12,13-dibutanoate increases secretion ISO RGD:736021 6480464 Phorbol 12, 13-Dibutyrate results in increased secretion of APP protein modified form CTD PMID:19476501 phorbol 12,13-dibutanoate multiple interactions ISO RGD:736021 6480464 Go 6976 inhibits the reaction [Phorbol 12, 13-Dibutyrate results in increased secretion of APP protein modified form] CTD PMID:19476501 phorbol 13-acetate 12-myristate multiple interactions ISO RGD:736022 6480464 [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of APP mRNA CTD PMID:19840844 phosphatidylcholine multiple interactions ISO RGD:736021 6480464 [[[APP protein modified form binds to Copper] which co-treated with Ascorbic Acid] results in increased oxidation of Phosphatidylcholines] which results in increased chemical synthesis of phosphatidylcholine hydroperoxide more ... CTD PMID:17964426 phosphoenolpyruvate multiple interactions ISO RGD:736021 6480464 Phosphoenolpyruvate inhibits the reaction [Rotenone results in decreased secretion of APP protein modified form] CTD PMID:22906069 phosphoenolpyruvate increases secretion ISO RGD:736021 6480464 Phosphoenolpyruvate results in increased secretion of APP protein modified form CTD PMID:22906069 physostigmine increases secretion EXP 6480464 Physostigmine results in increased secretion of APP protein modified form CTD PMID:7605915 , PMID:8624119 pioglitazone decreases expression ISO RGD:736021 6480464 pioglitazone results in decreased expression of APP protein mutant form CTD PMID:15817521 pioglitazone decreases expression ISO RGD:736022 6480464 pioglitazone results in decreased expression of APP protein CTD PMID:16407166 pioglitazone multiple interactions ISO RGD:736021 6480464 pioglitazone inhibits the reaction [[IFNG protein co-treated with IL1B protein] results in increased metabolism of and results in increased secretion of APP protein alternative form], pioglitazone inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased metabolism of and results in increased secretion of APP protein alternative form] CTD PMID:14586007 piperidine multiple interactions ISO RGD:736021 6480464 piperidine analog inhibits the reaction [ACHE protein promotes the reaction [APP protein binds to APP protein]], piperidine analog inhibits the reaction [APP protein binds to APP protein] CTD PMID:17681794 piperonyl butoxide increases expression EXP 6480464 Piperonyl Butoxide results in increased expression of APP mRNA CTD PMID:22484513 pirinixic acid decreases expression ISO RGD:736022 6480464 pirinixic acid results in decreased expression of APP mRNA CTD PMID:17426115 pirinixic acid multiple interactions EXP 6480464 pirinixic acid inhibits the reaction [APP protein results in decreased activity of CAT protein], pirinixic acid inhibits the reaction [APP protein results in decreased expression of CTNNB1 protein] CTD PMID:16204253 pirinixic acid affects activity EXP 6480464 pirinixic acid affects the activity of APP protein CTD PMID:16204253 poly(I:C) multiple interactions EXP 6480464 [Poly I-C co-treated with HU 211] results in decreased expression of APP mRNA CTD PMID:26923065 poly(vinylpyrrolidone) multiple interactions ISO RGD:736022 6480464 [Silver Compounds co-treated with Povidone] results in increased expression of APP protein CTD PMID:35697184 potassium atom multiple interactions EXP 6480464 [Zinc promotes the reaction [APP protein binds to APP protein]] which affects the transport of Potassium CTD PMID:16674922 potassium bromate increases expression ISO RGD:736021 6480464 potassium bromate results in increased expression of APP mRNA CTD PMID:30008028 pravastatin increases expression ISO RGD:736021 6480464 Pravastatin results in increased expression of APP CTD PMID:19461118 pregnenolone decreases response to substance EXP 6480464 Pregnenolone results in decreased susceptibility to APP protein modified form CTD PMID:18926803 pregnenolone 16alpha-carbonitrile increases expression EXP 6480464 Pregnenolone Carbonitrile results in increased expression of APP mRNA CTD PMID:19162173 proanthocyanidin multiple interactions EXP 6480464 Proanthocyanidins inhibits the reaction [lead acetate results in increased expression of APP protein modified form] CTD PMID:25088297 probucol multiple interactions EXP 6480464 Probucol inhibits the reaction [[Dietary Fats co-treated with Cholesterol more ... CTD PMID:26111763 , PMID:28734741 progesterone decreases metabolic processing ISO RGD:736022 6480464 APP gene mutant form results in decreased metabolism of Progesterone metabolite CTD PMID:17988898 progesterone multiple interactions ISO RGD:736022 6480464 Progesterone inhibits the reaction [APP gene mutant form results in decreased metabolism of Progesterone metabolite] CTD PMID:17988898 propiconazole increases expression EXP 6480464 propiconazole results in increased expression of APP mRNA CTD PMID:19423681 prostaglandin D2 increases secretion ISO RGD:736021 6480464 APP protein modified form results in increased secretion of Prostaglandin D2 CTD PMID:28721267 prostaglandin D2 multiple interactions ISO RGD:736021 6480464 CNB 001 inhibits the reaction [APP protein modified form results in increased secretion of Prostaglandin D2] more ... CTD PMID:28721267 prostaglandin E2 increases abundance EXP 6480464 APP protein modified form results in increased abundance of Dinoprostone CTD PMID:20171164 prostaglandin E2 multiple interactions ISO RGD:736021 6480464 CNB 001 inhibits the reaction [APP protein modified form results in increased secretion of Dinoprostone] more ... CTD PMID:28721267 prostaglandin E2 increases secretion ISO RGD:736021 6480464 APP protein modified form results in increased secretion of Dinoprostone CTD PMID:28721267 prostaglandin E2 multiple interactions ISO RGD:736022 6480464 [APP protein binds to APP protein binds to APP protein] which results in increased abundance of Dinoprostone, neoechinulin A inhibits the reaction [[APP protein binds to APP protein binds to APP protein] which results in increased abundance of Dinoprostone] CTD PMID:23261590 prostaglandin E2 multiple interactions EXP 6480464 PTGES2 promotes the reaction [APP protein modified form results in increased abundance of Dinoprostone], resveratrol inhibits the reaction [APP protein results in increased secretion of Dinoprostone] CTD PMID:16685418 , PMID:20171164 prostaglandin E2 increases expression EXP 6480464 Dinoprostone results in increased expression of APP protein modified form CTD PMID:20171164 prucalopride increases abundance ISO RGD:736022 6480464 prucalopride results in increased abundance of APP protein CTD PMID:18061284 pyrimethanil affects binding ISO RGD:736021 6480464 pyrimethanil binds to APP protein modified form CTD PMID:31939705 pyrimethanil multiple interactions ISO RGD:736021 6480464 [APP gene mutant form results in increased expression of APP protein modified form] which results in increased susceptibility to pyrimethanil more ... CTD PMID:31939705 pyrogallol multiple interactions ISO RGD:736021 6480464 [Copper binds to APP protein alternative form] which results in increased oxidation of Pyrogallol, Hydrogen Peroxide promotes the reaction [[Copper binds to APP protein alternative form] which results in increased oxidation of Pyrogallol] CTD PMID:15699049 pyrrolidine dithiocarbamate multiple interactions ISO RGD:736022 6480464 pyrrolidine dithiocarbamic acid results in decreased susceptibility to [APP protein modified form binds to APP protein modified form] CTD PMID:17409235 quercetin multiple interactions ISO RGD:736021 6480464 1H-(1 more ... CTD PMID:18001288 more ... quetiapine fumarate multiple interactions EXP 6480464 Quetiapine Fumarate inhibits the reaction [APP protein modified form affects the activity of CAT protein], Quetiapine Fumarate inhibits the reaction [APP protein modified form results in increased abundance of Reactive Oxygen Species] CTD PMID:15948179 quinine multiple interactions ISO RGD:736021 6480464 Quinine affects the reaction [APP protein binds to APP protein] CTD PMID:18537544 raloxifene affects binding ISO RGD:736021 6480464 Raloxifene Hydrochloride binds to APP protein CTD PMID:31583774 raloxifene multiple interactions ISO RGD:736021 6480464 Raloxifene Hydrochloride inhibits the reaction [APP protein results in increased expression of TGFB1 mRNA], Raloxifene Hydrochloride inhibits the reaction [APP protein results in increased expression of TNF mRNA] CTD PMID:31583774 reactive nitrogen species multiple interactions ISO RGD:736022 6480464 vitexin inhibits the reaction [APP protein modified form results in increased abundance of Reactive Nitrogen Species] CTD PMID:29545167 reactive nitrogen species increases abundance ISO RGD:736022 6480464 APP protein modified form results in increased abundance of Reactive Nitrogen Species CTD PMID:29545167 reactive oxygen species increases abundance EXP 6480464 APP protein modified form results in increased abundance of Reactive Oxygen Species CTD PMID:15030205 more ... reactive oxygen species multiple interactions ISO RGD:736022 6480464 vitexin inhibits the reaction [APP protein modified form results in increased abundance of Reactive Oxygen Species] CTD PMID:29545167 reactive oxygen species increases abundance ISO RGD:736022 6480464 APP protein modified form results in increased abundance of Reactive Oxygen Species CTD PMID:29545167 reactive oxygen species multiple interactions ISO RGD:736021 6480464 [Copper co-treated with APP protein modified form] results in increased abundance of Reactive Oxygen Species more ... CTD PMID:19464278 , PMID:21706413 reactive oxygen species increases abundance ISO RGD:736021 6480464 APP protein results in increased abundance of Reactive Oxygen Species CTD PMID:19464278 reactive oxygen species multiple interactions EXP 6480464 Ascorbic Acid inhibits the reaction [APP protein modified form results in increased abundance of Reactive Oxygen Species] more ... CTD PMID:15030205 more ... resveratrol affects folding ISO RGD:736021 6480464 resveratrol affects the folding of APP protein modified form CTD PMID:23386614 resveratrol decreases response to substance EXP 6480464 resveratrol results in decreased susceptibility to APP protein CTD PMID:15134381 resveratrol multiple interactions EXP 6480464 resveratrol inhibits the reaction [APP protein modified form results in decreased abundance of Ascorbic Acid] more ... CTD PMID:15134381 more ... resveratrol decreases secretion ISO RGD:736022 6480464 resveratrol results in decreased secretion of APP protein mutant form CTD PMID:16162502 resveratrol increases degradation ISO RGD:736021 6480464 resveratrol results in increased degradation of APP protein modified form CTD PMID:20080969 resveratrol decreases expression ISO RGD:736021 6480464 resveratrol results in decreased expression of APP protein modified form CTD PMID:20080969 resveratrol affects binding ISO RGD:736021 6480464 resveratrol binds to [APP protein binds to APP protein] CTD PMID:17597573 resveratrol multiple interactions ISO RGD:736021 6480464 [Plant Extracts co-treated with Resveratrol] results in increased expression of APP mRNA more ... CTD PMID:16162502 more ... resveratrol decreases expression ISO RGD:736022 6480464 resveratrol results in decreased expression of APP protein, resveratrol results in decreased expression of APP protein modified form CTD PMID:20080969 more ... resveratrol multiple interactions ISO RGD:736022 6480464 resveratrol inhibits the reaction [APP protein results in decreased expression of and results in decreased activity of SIRT1 protein] more ... CTD PMID:22118570 , PMID:24254769 rimonabant multiple interactions ISO RGD:736022 6480464 Rimonabant inhibits the reaction [Dietary Fats results in increased expression of APP mRNA] CTD PMID:19030233 rimonabant affects expression ISO RGD:736022 6480464 Rimonabant affects the expression of APP mRNA CTD PMID:19030233 rotenone decreases secretion ISO RGD:736021 6480464 Rotenone results in decreased secretion of APP protein modified form CTD PMID:22906069 rotenone multiple interactions ISO RGD:736021 6480464 Adenosine Triphosphate inhibits the reaction [Rotenone results in decreased secretion of APP protein modified form] more ... CTD PMID:22906069 rottlerin multiple interactions EXP 6480464 rottlerin inhibits the reaction [PRKCD protein promotes the reaction [Lead results in increased localization of APP protein]] CTD PMID:20488202 ruthenium red multiple interactions EXP 6480464 Ruthenium Red inhibits the reaction [APP protein modified form results in increased uptake of Calcium] CTD PMID:24457011 S-adenosyl-L-homocysteine increases expression ISO RGD:736022 6480464 S-Adenosylhomocysteine results in increased expression of APP protein CTD PMID:22064374 S-adenosyl-L-homocysteine decreases methylation ISO RGD:736022 6480464 S-Adenosylhomocysteine results in decreased methylation of APP promoter CTD PMID:19635394 S-adenosyl-L-homocysteine multiple interactions ISO RGD:736022 6480464 Betaine inhibits the reaction [S-Adenosylhomocysteine results in decreased methylation of APP promoter] more ... CTD PMID:19635394 S-adenosyl-L-methioninate increases secretion ISO RGD:736021 6480464 S-Adenosylmethionine results in increased secretion of APP protein modified form CTD PMID:22906069 S-adenosyl-L-methionine increases secretion ISO RGD:736021 6480464 S-Adenosylmethionine results in increased secretion of APP protein modified form CTD PMID:22906069 salicylates multiple interactions EXP 6480464 Salicylates inhibits the reaction [APP protein results in increased uptake of Calcium] CTD PMID:18648507 sapropterin multiple interactions ISO RGD:736021 6480464 APP gene mutant form results in increased oxidation of and results in decreased abundance of sapropterin, GW 501516 inhibits the reaction [APP gene mutant form results in increased oxidation of and results in decreased abundance of sapropterin] CTD PMID:22886847 sarin decreases expression ISO RGD:736021 6480464 Sarin results in decreased expression of APP mRNA CTD PMID:19522546 SB 203580 multiple interactions ISO RGD:736021 6480464 SB 203580 inhibits the reaction [APP protein results in increased expression of and results in increased cleavage of CASP1 protein] more ... CTD PMID:18583042 , PMID:28004443 SB 415286 multiple interactions ISO RGD:736021 6480464 3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2, 5-dione inhibits the reaction [Copper affects the localization of APP protein] CTD PMID:24610780 SCH772984 multiple interactions EXP 6480464 SCH772984 inhibits the reaction [APP protein modified form results in increased expression of GRK2 protein] CTD PMID:30399361 scopolamine decreases cleavage ISO RGD:736022 6480464 Scopolamine results in decreased cleavage of APP protein CTD PMID:16423497 scutellarin multiple interactions EXP 6480464 scutellarin inhibits the reaction [APP protein binds to APP protein] CTD PMID:17323972 selenium atom decreases expression ISO RGD:736021 6480464 Selenium results in decreased expression of APP mRNA CTD PMID:19244175 selenomethionine multiple interactions EXP 6480464 Selenomethionine inhibits the reaction [APP protein results in decreased expression of and results in decreased activity of GPX1 protein] CTD PMID:17280487 serotonin increases response to substance ISO RGD:736021 6480464 APP protein modified form results in increased susceptibility to Serotonin CTD PMID:28915354 , PMID:34902447 serotonin multiple interactions ISO RGD:736021 6480464 Oils more ... CTD PMID:28915354 , PMID:34902447 sevoflurane multiple interactions ISO RGD:736021 6480464 APP protein modified form promotes the reaction [sevoflurane results in increased cleavage of CASP3 protein] more ... CTD PMID:19433662 sevoflurane increases expression EXP 6480464 Sevoflurane results in increased expression of APP protein CTD PMID:35174938 sevoflurane multiple interactions EXP 6480464 Dietary Fats promotes the reaction [Sevoflurane results in increased expression of APP protein] CTD PMID:35174938 sevoflurane increases expression ISO RGD:736021 6480464 sevoflurane results in increased expression of APP protein modified form CTD PMID:19433662 sevoflurane affects cleavage ISO RGD:736021 6480464 sevoflurane affects the cleavage of APP protein CTD PMID:19433662 sevoflurane increases expression ISO RGD:736022 6480464 sevoflurane results in increased expression of APP protein modified form CTD PMID:19433662 sevoflurane multiple interactions ISO RGD:736022 6480464 sevoflurane promotes the reaction [CASP3 protein results in increased cleavage of APP protein] CTD PMID:19433662 silicon dioxide affects secretion ISO RGD:736021 6480464 Silicon Dioxide analog affects the secretion of APP protein CTD PMID:25895662 silicon dioxide increases expression ISO RGD:736021 6480464 Silicon Dioxide analog results in increased expression of APP protein CTD PMID:24831964 silicon dioxide increases expression ISO RGD:736022 6480464 Silicon Dioxide analog results in increased expression of APP protein CTD PMID:24831964 silver atom increases expression ISO RGD:736022 6480464 Silver results in increased expression of APP mRNA more ... CTD PMID:27131904 silver(0) increases expression ISO RGD:736022 6480464 Silver results in increased expression of APP mRNA more ... CTD PMID:27131904 simvastatin multiple interactions ISO RGD:736021 6480464 oblimersen inhibits the reaction [Simvastatin results in decreased activity of APP protein alternative form] more ... CTD PMID:17241114 simvastatin multiple interactions EXP 6480464 Simvastatin inhibits the reaction [[Dietary Fats co-treated with Cholesterol, Dietary] results in increased expression of APP protein] CTD PMID:28734741 simvastatin decreases activity ISO RGD:736021 6480464 Simvastatin results in decreased activity of APP protein alternative form CTD PMID:17241114 sirolimus decreases expression ISO RGD:736021 6480464 Sirolimus results in decreased expression of APP protein modified form CTD PMID:20542014 sirolimus increases expression ISO RGD:736021 6480464 Sirolimus results in increased expression of APP protein modified form CTD PMID:20542014 sirolimus increases expression ISO RGD:736022 6480464 Sirolimus results in increased expression of APP protein modified form CTD PMID:20542014 sirolimus decreases expression ISO RGD:736022 6480464 Sirolimus results in decreased expression of APP protein modified form CTD PMID:20542014 sirtinol multiple interactions ISO RGD:736022 6480464 sirtinol inhibits the reaction [cilostazol inhibits the reaction [APP protein results in decreased expression of and results in decreased activity of SIRT1 protein]] CTD PMID:24254769 sodium arsenite increases expression ISO RGD:736021 6480464 sodium arsenite results in increased expression of APP mRNA CTD PMID:12760830 sodium arsenite increases expression ISO RGD:736022 6480464 sodium arsenite results in increased expression of APP mRNA, sodium arsenite results in increased expression of APP protein CTD PMID:21440049 , PMID:36209798 sodium arsenite multiple interactions ISO RGD:736021 6480464 sodium arsenite results in increased cleavage of and affects the secretion of APP protein mutant form, sodium arsenite results in increased expression of and affects the localization of APP protein mutant form CTD PMID:21440049 sodium azide multiple interactions ISO RGD:736021 6480464 [Sodium Azide co-treated with Deoxyglucose] affects the cleavage of and affects the localization of APP protein, Sodium Azide inhibits the reaction [Adenosine Triphosphate results in increased secretion of APP protein modified form] CTD PMID:17405930 , PMID:22906069 sodium dichromate affects expression EXP 6480464 sodium bichromate affects the expression of APP mRNA CTD PMID:22110744 sodium nitrite multiple interactions ISO RGD:736021 6480464 [Hydrogen Peroxide co-treated with Sodium Nitrite] promotes the reaction [APP protein modified form binds to Heme] CTD PMID:25211009 staurosporine multiple interactions ISO RGD:736021 6480464 Staurosporine inhibits the reaction [Ginkgo biloba extract inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein]], Staurosporine promotes the reaction [PSEN2 protein mutant form results in increased expression of APP protein] CTD PMID:12556443 , PMID:18001288 streptozocin multiple interactions EXP 6480464 Memantine inhibits the reaction [Streptozocin results in increased expression of APP protein modified form] CTD PMID:21290839 streptozocin multiple interactions ISO RGD:736022 6480464 5-Methoxypsoralen inhibits the reaction [Streptozocin results in increased expression of APP protein modified form] more ... CTD PMID:30481507 , PMID:34428446 streptozocin increases expression ISO RGD:736022 6480464 Streptozocin results in increased expression of APP mRNA more ... CTD PMID:21069392 more ... streptozocin increases expression EXP 6480464 Streptozocin results in increased expression of APP protein modified form CTD PMID:21290839 sulindac multiple interactions ISO RGD:736021 6480464 Sulindac inhibits the reaction [CDKN1A protein results in increased expression of APP mRNA] CTD PMID:15190207 sulindac sulfide multiple interactions ISO RGD:736021 6480464 [sulindac sulfide results in decreased activity of PSEN1 protein] which affects the cleavage of APP protein more ... CTD PMID:12805356 more ... sulindac sulfide multiple interactions EXP 6480464 sulindac sulfide inhibits the reaction [APP protein results in increased uptake of Calcium] CTD PMID:18648507 sulindac sulfide affects cleavage ISO RGD:736022 6480464 sulindac sulfide affects the cleavage of APP protein CTD PMID:14690522 sulindac sulfide affects cleavage ISO RGD:736021 6480464 sulindac sulfide affects the cleavage of APP protein CTD PMID:11700559 more ... superoxide multiple interactions ISO RGD:736021 6480464 3-benzyl-7-(2-benzoxazolyl)thio-1 more ... CTD PMID:16212921 , PMID:22886847 superoxide increases chemical synthesis ISO RGD:736021 6480464 APP gene mutant form results in increased chemical synthesis of Superoxides CTD PMID:22886847 T-2 toxin decreases expression EXP 6480464 T-2 Toxin results in decreased expression of APP mRNA CTD PMID:26141394 tadalafil multiple interactions ISO RGD:736022 6480464 Tadalafil inhibits the reaction [Streptozocin results in increased expression of APP protein modified form] CTD PMID:34428446 tamoxifen affects expression ISO RGD:736022 6480464 Tamoxifen affects the expression of APP mRNA CTD PMID:17555576 tamoxifen decreases expression ISO RGD:736022 6480464 Tamoxifen results in decreased expression of APP mRNA CTD PMID:19400957 tamoxifen decreases expression EXP 6480464 Tamoxifen results in decreased expression of APP mRNA CTD PMID:19400957 tauroursodeoxycholic acid multiple interactions EXP 6480464 ursodoxicoltaurine affects the reaction [APP protein modified form affects the localization of NR3C2 protein] more ... CTD PMID:16728529 , PMID:18368144 tauroursodeoxycholic acid multiple interactions ISO RGD:736021 6480464 ursodoxicoltaurine inhibits the reaction [[APP gene mutant form co-treated with PSEN1 gene mutant form] results in decreased expression of BCL2 protein] more ... CTD PMID:16923170 terbufos increases methylation ISO RGD:736021 6480464 terbufos results in increased methylation of APP promoter CTD PMID:22847954 tert-butyl hydroperoxide decreases expression ISO RGD:736021 6480464 tert-Butylhydroperoxide results in decreased expression of APP mRNA CTD PMID:12419474 testosterone enanthate affects expression ISO RGD:736021 6480464 testosterone enanthate affects the expression of APP mRNA CTD PMID:17440010 tetrachloromethane decreases expression ISO RGD:736022 6480464 Carbon Tetrachloride results in decreased expression of APP mRNA CTD PMID:17484886 tetrachloromethane increases expression EXP 6480464 Carbon Tetrachloride results in increased expression of APP mRNA CTD PMID:31150632 tetrachloromethane increases expression ISO RGD:736022 6480464 Carbon Tetrachloride results in increased expression of APP mRNA CTD PMID:27339419 , PMID:31919559 tetrahydrocurcumin multiple interactions ISO RGD:736021 6480464 tetrahydrocurcumin inhibits the reaction [APP protein binds to APP protein] CTD PMID:19715544 tetrathiomolybdate(2-) multiple interactions ISO RGD:736021 6480464 [tetrathiomolybdate binds to APP 5' UTR] which results in decreased expression of APP protein, [tetrathiomolybdate binds to APP 5' UTR] which results in decreased secretion of APP protein modified form CTD PMID:15681799 tetrathiomolybdate(2-) affects binding ISO RGD:736021 6480464 tetrathiomolybdate binds to APP 5' UTR CTD PMID:15681799 tetrodotoxin multiple interactions ISO RGD:736022 6480464 Tetrodotoxin inhibits the reaction [DDT results in increased expression of APP mRNA], Tetrodotoxin inhibits the reaction [DDT results in increased expression of APP protein] CTD PMID:35946953 tetrodotoxin multiple interactions ISO RGD:736021 6480464 Tetrodotoxin inhibits the reaction [DDT results in increased expression of APP mRNA] CTD PMID:35946953 thapsigargin increases expression EXP 6480464 Thapsigargin results in increased expression of APP protein CTD PMID:35544339 thiethylperazine multiple interactions ISO RGD:736022 6480464 [Thiethylperazine results in increased activity of ABCC1 protein] which results in increased export of APP protein CTD PMID:21881209 thioacetamide increases expression EXP 6480464 Thioacetamide results in increased expression of APP mRNA CTD PMID:23411599 thiourea increases uptake ISO RGD:736022 6480464 Thiourea results in increased uptake of APP protein modified form CTD PMID:20637185 thymoquinone multiple interactions EXP 6480464 thymoquinone inhibits the reaction [[Dietary Fats co-treated with Cholesterol more ... CTD PMID:28734741 thyroxine decreases cleavage ISO RGD:736022 6480464 Thyroxine results in decreased cleavage of APP protein CTD PMID:17199430 thyroxine decreases expression ISO RGD:736022 6480464 Thyroxine results in decreased expression of APP mRNA, Thyroxine results in decreased expression of APP protein CTD PMID:17199430 titanium dioxide multiple interactions ISO RGD:736022 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of APP mRNA CTD PMID:29950665 titanium dioxide increases expression ISO RGD:736022 6480464 titanium dioxide results in increased expression of APP mRNA CTD PMID:23557971 tocopherol decreases abundance EXP 6480464 APP protein modified form results in decreased abundance of Tocopherols CTD PMID:25654502 tocopherol multiple interactions EXP 6480464 resveratrol inhibits the reaction [APP protein modified form results in decreased abundance of Tocopherols] CTD PMID:25654502 tolfenamic acid multiple interactions ISO RGD:736021 6480464 [lead acetate co-treated with tolfenamic acid] results in decreased expression of APP mRNA, tolfenamic acid inhibits the reaction [lead acetate results in increased expression of APP protein modified form] CTD PMID:24462621 tolonium chloride decreases secretion ISO RGD:736022 6480464 Tolonium Chloride results in decreased secretion of APP protein modified form CTD PMID:36027949 toluene affects expression EXP 6480464 Toluene affects the expression of APP mRNA CTD PMID:21827849 trans-caffeic acid multiple interactions ISO RGD:736022 6480464 caffeic acid inhibits the reaction [aluminum chloride results in increased expression of APP protein modified form], caffeic acid inhibits the reaction [aluminum chloride results in increased expression of APP protein] CTD PMID:18482095 trenbolone affects expression EXP 6480464 Trenbolone Acetate analog affects the expression of APP protein modified form CTD PMID:25461682 trenbolone multiple interactions EXP 6480464 Dihydrotestosterone promotes the reaction [Trenbolone Acetate analog results in increased expression of APP protein modified form] more ... CTD PMID:25461682 trenbolone increases expression EXP 6480464 Trenbolone Acetate analog results in increased expression of APP protein modified form CTD PMID:25461682 triadimefon increases expression EXP 6480464 triadimefon results in increased expression of APP mRNA CTD PMID:19423681 trichlorfon increases secretion ISO RGD:736021 6480464 Trichlorfon results in increased secretion of APP protein alternative form CTD PMID:11526466 trichlorfon affects metabolic processing EXP 6480464 Trichlorfon affects the metabolism of APP protein CTD PMID:10773217 trichlorfon affects cleavage EXP 6480464 Trichlorfon affects the cleavage of APP protein CTD PMID:11099780 , PMID:11822883 trilostane multiple interactions EXP 6480464 trilostane inhibits the reaction [Dihydrotestosterone promotes the reaction [Trenbolone Acetate analog results in increased expression of APP protein modified form]] CTD PMID:25461682 trimellitic anhydride decreases expression ISO RGD:736022 6480464 trimellitic anhydride results in decreased expression of APP mRNA CTD PMID:19042947 triolein multiple interactions EXP 6480464 Triolein inhibits the reaction [[Dietary Fats co-treated with Cholesterol more ... CTD PMID:28734741 triphenyl phosphate increases expression EXP 6480464 triphenyl phosphate results in increased expression of APP mRNA CTD PMID:30589522 tris(2-butoxyethyl) phosphate affects expression ISO RGD:736021 6480464 tris(2-butoxyethyl) phosphate affects the expression of APP mRNA CTD PMID:29024780 troglitazone increases expression ISO RGD:736021 6480464 troglitazone results in increased expression of APP mRNA CTD PMID:19140230 tubocurarine multiple interactions ISO RGD:736021 6480464 Tubocurarine inhibits the reaction [[Nicotine results in increased metabolism of APP protein] which results in increased secretion of APP protein modified form], Tubocurarine inhibits the reaction [Nicotine results in increased metabolism of APP protein] CTD PMID:29618714 tunicamycin multiple interactions ISO RGD:736021 6480464 [Tunicamycin co-treated with APP protein modified form] results in increased expression of PSEN1 mRNA more ... CTD PMID:22115781 tunicamycin increases secretion ISO RGD:736021 6480464 Tunicamycin results in increased secretion of APP protein modified form CTD PMID:22115781 uranium atom affects expression ISO RGD:736021 6480464 Uranium affects the expression of APP mRNA CTD PMID:15672453 urethane increases expression ISO RGD:736021 6480464 Urethane results in increased expression of APP mRNA CTD PMID:28818685 ursolic acid multiple interactions ISO RGD:736021 6480464 ursolic acid inhibits the reaction [APP protein modified form results in decreased expression of RPT-3 protein], ursolic acid inhibits the reaction [APP protein modified form results in increased susceptibility to Serotonin] CTD PMID:34902447 valdecoxib increases expression EXP 6480464 valdecoxib results in increased expression of APP mRNA CTD PMID:24136188 valproic acid increases expression ISO RGD:736022 6480464 Valproic Acid results in increased expression of APP mRNA CTD PMID:22045034 valproic acid increases expression ISO RGD:736021 6480464 Valproic Acid results in increased expression of APP mRNA CTD PMID:23179753 more ... vinclozolin affects expression EXP 6480464 vinclozolin affects the expression of APP mRNA CTD PMID:19015723 vitamin E decreases expression ISO RGD:736021 6480464 Vitamin E results in decreased expression of APP mRNA CTD PMID:19244175 vitamin E multiple interactions EXP 6480464 Vitamin E inhibits the reaction [APP protein modified form promotes the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased expression of NOS2 protein]], Vitamin E inhibits the reaction [APP protein results in increased activity of CASP3] CTD PMID:12117551 , PMID:15223066 vitamin E multiple interactions ISO RGD:736022 6480464 Vitamin E inhibits the reaction [Aluminum results in increased cleavage of APP protein] CTD PMID:12039845 vitexin multiple interactions ISO RGD:736022 6480464 vitexin inhibits the reaction [APP protein modified form results in decreased abundance of Glutathione] more ... CTD PMID:29545167 vitexin decreases expression ISO RGD:736021 6480464 vitexin results in decreased expression of APP mRNA, vitexin results in decreased expression of APP protein CTD PMID:32926499 WIN 55212-2 multiple interactions ISO RGD:736022 6480464 (3R)-((2 more ... CTD PMID:21350020 Y-27632 multiple interactions ISO RGD:736022 6480464 ROCK1 protein affects the reaction [Y 27632 affects the cleavage of APP protein] CTD PMID:14615541 Y-27632 multiple interactions EXP 6480464 Y 27632 inhibits the reaction [aluminum maltolate results in decreased expression of and results in decreased secretion of APP protein modified form] CTD PMID:20395307 Y-27632 increases secretion EXP 6480464 Y 27632 results in increased secretion of APP protein modified form CTD PMID:19741129 Y-27632 affects cleavage ISO RGD:736022 6480464 Y 27632 affects the cleavage of APP protein CTD PMID:14615541 zebularine multiple interactions ISO RGD:736021 6480464 pyrimidin-2-one beta-ribofuranoside inhibits the reaction [Folic Acid results in decreased expression of APP protein] CTD PMID:26492244 zinc atom multiple interactions ISO RGD:736021 6480464 Clioquinol inhibits the reaction [Zinc results in increased secretion of APP protein alternative form] more ... CTD PMID:12572668 more ... zinc atom increases expression EXP 6480464 Zinc deficiency results in increased expression of APP mRNA CTD PMID:19111725 zinc atom multiple interactions ISO RGD:736022 6480464 [APP protein co-treated with Zinc] results in increased degradation of GPC1 protein modified form CTD PMID:15677459 zinc atom increases degradation ISO RGD:736021 6480464 Zinc results in increased degradation of APP protein modified form CTD PMID:18068270 zinc atom multiple interactions EXP 6480464 [Zinc promotes the reaction [APP protein binds to APP protein]] which affects the transport of Potassium CTD PMID:16674922 zinc atom increases secretion ISO RGD:736021 6480464 Zinc results in increased secretion of APP protein alternative form CTD PMID:16648635 zinc atom affects binding ISO RGD:736021 6480464 APP protein binds to Zinc more ... CTD PMID:15699049 more ... zinc(0) multiple interactions ISO RGD:736021 6480464 Clioquinol inhibits the reaction [Zinc results in increased secretion of APP protein alternative form] more ... CTD PMID:12572668 more ... zinc(0) affects binding ISO RGD:736021 6480464 APP protein binds to Zinc more ... CTD PMID:15699049 more ... zinc(0) increases secretion ISO RGD:736021 6480464 Zinc results in increased secretion of APP protein alternative form CTD PMID:16648635 zinc(0) multiple interactions EXP 6480464 [Zinc promotes the reaction [APP protein binds to APP protein]] which affects the transport of Potassium CTD PMID:16674922 zinc(0) increases degradation ISO RGD:736021 6480464 Zinc results in increased degradation of APP protein modified form CTD PMID:18068270 zinc(0) multiple interactions ISO RGD:736022 6480464 [APP protein co-treated with Zinc] results in increased degradation of GPC1 protein modified form CTD PMID:15677459 zinc(0) increases expression EXP 6480464 Zinc deficiency results in increased expression of APP mRNA CTD PMID:19111725
