App Rat (+)-catechin decreases response to substance EXP 6480464 Catechin results in decreased susceptibility to APP protein CTD PMID:15134381 App Rat (+)-catechin multiple interactions EXP 6480464 resveratrol promotes the reaction [Catechin results in decreased susceptibility to APP protein] CTD PMID:15134381 App Rat (-)-epigallocatechin 3-gallate affects folding ISO RGD:736021 6480464 epigallocatechin gallate affects the folding of APP protein modified form CTD PMID:23386614 App Rat (1->4)-beta-D-glucan multiple interactions ISO RGD:736022 6480464 [perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of APP mRNA CTD PMID:36331819 App Rat (24S)-24-hydroxycholesterol multiple interactions ISO RGD:736021 6480464 24-hydroxycholesterol affects the metabolism of and results in increased activity of APP protein; 24-hydroxycholesterol results more ... CTD PMID:15148325|PMID:17532301 App Rat (24S)-24-hydroxycholesterol increases metabolic processing ISO RGD:736021 6480464 24-hydroxycholesterol results in increased metabolism of APP protein CTD PMID:19126211 App Rat (25R)-cholest-5-ene-3beta,26-diol multiple interactions ISO RGD:736021 6480464 27-hydroxycholesterol results in decreased metabolism of and results in decreased secretion of APP protein CTD PMID:15148325 App Rat (25R)-cholest-5-ene-3beta,26-diol increases expression ISO RGD:736021 6480464 27-hydroxycholesterol results in increased expression of APP protein alternative form CTD PMID:19126211 App Rat (25R)-cholest-5-ene-3beta,26-diol decreases secretion ISO RGD:736021 6480464 27-hydroxycholesterol results in decreased secretion of APP protein alternative form CTD PMID:19158428 App Rat (5Z,8Z,11Z,13E)-15-HETE increases secretion ISO RGD:736021 6480464 APP protein modified form results in increased secretion of 15-hydroxy-5,8,11,13-eicosatetraenoic acid CTD PMID:28721267 App Rat (5Z,8Z,11Z,13E)-15-HETE multiple interactions ISO RGD:736021 6480464 CNB 001 inhibits the reaction [APP protein modified form results in increased secretion of 15-hydroxy-5,8,11,13-eicosatetraenoic more ... CTD PMID:28721267 App Rat (R)-carnitine multiple interactions ISO RGD:736021 6480464 Carnitine promotes the reaction [Paraquat deficiency inhibits the reaction [Paraquat promotes the reaction [APP protein more ... CTD PMID:33290254 App Rat (R,R,R)-alpha-tocopherol multiple interactions ISO RGD:736021 6480464 alpha-Tocopherol inhibits the reaction [APP protein results in increased activity of MAPK14 protein]; alpha-Tocopherol inhibits more ... CTD PMID:12684028 App Rat (S)-naringenin multiple interactions EXP 6480464 naringenin inhibits the reaction [APP protein modified form results in increased abundance of Reactive Oxygen more ... CTD PMID:15030205 App Rat (S)-nicotine decreases expression ISO RGD:736021 6480464 Nicotine results in decreased expression of APP mRNA; Nicotine results in decreased expression of APP more ... CTD PMID:16627626 App Rat (S)-nicotine increases metabolic processing ISO RGD:736021 6480464 Nicotine results in increased metabolism of APP protein CTD PMID:29618714 App Rat (S)-nicotine multiple interactions ISO RGD:736021 6480464 [Nicotine results in increased metabolism of APP protein] which results in increased secretion of APP more ... CTD PMID:16627626|PMID:29618714 App Rat (S)-nicotine multiple interactions EXP 6480464 APP protein modified form inhibits the reaction [Nicotine results in increased secretion of Acetylcholine]; spiro(imidazo-(1,2-a)pyridine-3,2-indan)-2(3H)-one more ... CTD PMID:16474004 App Rat (S)-nicotine decreases expression ISO RGD:736022 6480464 Nicotine results in decreased expression of APP protein alternative form CTD PMID:17135361 App Rat (Z)-ligustilide decreases expression ISO RGD:736022 6480464 ligustilide results in decreased expression of APP protein CTD PMID:23973442 App Rat 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane affects expression EXP 6480464 o,p'-DDT affects the expression of APP mRNA CTD PMID:17984292 App Rat 1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene multiple interactions ISO RGD:736022 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:26480858 App Rat 1,2-dimethylhydrazine multiple interactions ISO RGD:736022 6480464 [1,2-Dimethylhydrazine co-treated with Folic Acid] results in increased expression of APP mRNA CTD PMID:22206623 App Rat 1-naphthyl isothiocyanate affects expression EXP 6480464 1-Naphthylisothiocyanate affects the expression of APP mRNA CTD PMID:25380136 App Rat 1-naphthyl isothiocyanate increases expression EXP 6480464 1-Naphthylisothiocyanate results in increased expression of APP mRNA CTD PMID:30723492 App Rat 17alpha-ethynylestradiol decreases expression ISO RGD:736022 6480464 Ethinyl Estradiol results in decreased expression of APP mRNA CTD PMID:19400957 App Rat 17alpha-ethynylestradiol decreases expression EXP 6480464 Ethinyl Estradiol results in decreased expression of APP mRNA CTD PMID:19400957 App Rat 17alpha-ethynylestradiol multiple interactions ISO RGD:736022 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of APP mRNA CTD PMID:17942748 App Rat 17alpha-ethynylestradiol increases expression ISO RGD:736022 6480464 Ethinyl Estradiol results in increased expression of APP mRNA CTD PMID:17942748 App Rat 17alpha-ethynylestradiol affects expression ISO RGD:736022 6480464 Ethinyl Estradiol affects the expression of APP mRNA CTD PMID:17555576 App Rat 17beta-estradiol multiple interactions ISO RGD:736021 6480464 Estradiol inhibits the reaction [APP protein results in decreased expression of BCL2 protein]; Estradiol inhibits more ... CTD PMID:12182891|PMID:12963085|PMID:34318539 App Rat 17beta-estradiol multiple interactions ISO RGD:736022 6480464 Estradiol inhibits the reaction [[Galactose co-treated with Aluminum Chloride] results in decreased expression of APP more ... CTD PMID:35537655 App Rat 17beta-estradiol affects expression ISO RGD:736022 6480464 Estradiol affects the expression of APP mRNA CTD PMID:39298647 App Rat 17beta-estradiol multiple interactions EXP 6480464 [BDNF protein co-treated with MF63 compound co-treated with Estradiol] inhibits the reaction [Paraquat results in more ... CTD PMID:31715309|PMID:32738378 App Rat 17beta-estradiol decreases expression ISO RGD:736022 6480464 Estradiol results in decreased expression of APP mRNA CTD PMID:22467019 App Rat 17beta-hydroxy-5alpha-androstan-3-one decreases expression ISO RGD:736022 6480464 Dihydrotestosterone results in decreased expression of APP mRNA CTD PMID:17023530 App Rat 17beta-hydroxy-5alpha-androstan-3-one multiple interactions EXP 6480464 Dihydrotestosterone promotes the reaction [Trenbolone Acetate analog results in increased expression of APP protein modified more ... CTD PMID:25461682 App Rat 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one multiple interactions ISO RGD:736021 6480464 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Ginkgo biloba extract inhibits the reaction [APP protein results in decreased more ... CTD PMID:18001288 App Rat 2,2',4,4',5,5'-hexachlorobiphenyl multiple interactions ISO RGD:736022 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:26480858 App Rat 2,2',4,4'-Tetrabromodiphenyl ether increases expression EXP 6480464 2,2',4,4'-tetrabromodiphenyl ether results in increased expression of APP mRNA CTD PMID:27291303|PMID:32679240 App Rat 2,2',5,5'-tetrachlorobiphenyl multiple interactions ISO RGD:736022 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:26480858 App Rat 2,2'-Methylenebis(4-methyl-6-tert-butylphenol) multiple interactions ISO RGD:736021 6480464 [CYP3A4 protein affects the susceptibility to 2,2'-methylenebis(4-methyl-6-tert-butylphenol)] which affects the expression of APP mRNA CTD PMID:38160208 App Rat 2,2,2-tetramine multiple interactions ISO RGD:736021 6480464 Trientine inhibits the reaction [[[[APP protein modified form binds to Copper] which co-treated with Ascorbic more ... CTD PMID:12963085|PMID:17964426 App Rat 2,2,2-tetramine multiple interactions ISO RGD:736022 6480464 Trientine results in decreased expression of and affects the localization of APP protein modified form CTD PMID:23541064 App Rat 2,2,2-tetramine decreases cleavage ISO RGD:736022 6480464 Trientine results in decreased cleavage of APP protein CTD PMID:23541064 App Rat 2,2,2-tetramine decreases expression ISO RGD:736021 6480464 Trientine results in decreased expression of APP protein modified form CTD PMID:23541064 App Rat 2,2,2-tetramine increases metabolic processing ISO RGD:736021 6480464 Trientine results in increased metabolism of APP protein CTD PMID:10940226 App Rat 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:736022 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of APP mRNA; Tetrachlorodibenzodioxin affects the more ... CTD PMID:17942748|PMID:19654925 App Rat 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of APP mRNA CTD PMID:34747641 App Rat 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:736022 6480464 Tetrachlorodibenzodioxin affects the expression of APP mRNA CTD PMID:21570461 App Rat 2,3-dihydroxybenzoic acid multiple interactions ISO RGD:736021 6480464 2,3-dihydroxybenzoic acid inhibits the reaction [APP protein modified form binds to APP protein modified form]; more ... CTD PMID:22129351 App Rat 2,4,4'-trichlorobiphenyl multiple interactions ISO RGD:736022 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:26480858 App Rat 2,4-dinitrophenol affects localization ISO RGD:736022 6480464 2,4-Dinitrophenol affects the localization of APP protein CTD PMID:18949129 App Rat 2,4-dinitrophenol multiple interactions ISO RGD:736022 6480464 2,4-Dinitrophenol affects the reaction [APP protein affects the abundance of Calcium] CTD PMID:18949129 App Rat 2,5-dihydroxybenzoic acid multiple interactions ISO RGD:736021 6480464 2,5-dihydroxybenzoic acid inhibits the reaction [APP protein modified form binds to APP protein modified form]; more ... CTD PMID:22129351 App Rat 2,6-dinitrotoluene affects expression EXP 6480464 2,6-dinitrotoluene affects the expression of APP mRNA CTD PMID:21346803 App Rat 2-deoxy-D-glucose multiple interactions ISO RGD:736021 6480464 [Sodium Azide co-treated with Deoxyglucose] affects the cleavage of and affects the localization of APP more ... CTD PMID:17405930 App Rat 2-ethoxyethanol increases expression EXP 6480464 2-ethoxyethanol results in increased expression of APP mRNA CTD PMID:19643169 App Rat 2-hydroxypropanoic acid decreases abundance ISO RGD:736021 6480464 APP protein mutant form results in decreased abundance of Lactic Acid CTD PMID:39172838 App Rat 2-hydroxypropanoic acid multiple interactions ISO RGD:736021 6480464 PF-06840003 inhibits the reaction [APP protein mutant form results in decreased abundance of Lactic Acid] CTD PMID:39172838 App Rat 2-methoxyethanol increases expression EXP 6480464 methyl cellosolve results in increased expression of APP mRNA CTD PMID:19643169 App Rat 26-hydroxycholesterol multiple interactions ISO RGD:736021 6480464 27-hydroxycholesterol results in decreased metabolism of and results in decreased secretion of APP protein CTD PMID:15148325 App Rat 26-hydroxycholesterol decreases secretion ISO RGD:736021 6480464 27-hydroxycholesterol results in decreased secretion of APP protein alternative form CTD PMID:19158428 App Rat 26-hydroxycholesterol increases expression ISO RGD:736021 6480464 27-hydroxycholesterol results in increased expression of APP protein alternative form CTD PMID:19126211 App Rat 3,3',5,5'-tetrabromobisphenol A increases secretion ISO RGD:736021 6480464 tetrabromobisphenol A results in increased secretion of APP protein modified form CTD PMID:22485137 App Rat 3,3',5,5'-tetrabromobisphenol A decreases expression EXP 6480464 tetrabromobisphenol A results in decreased expression of APP mRNA CTD PMID:28970181 App Rat 3,3',5-triiodo-L-thyronine decreases expression ISO RGD:736021 6480464 Triiodothyronine results in decreased expression of APP mRNA; Triiodothyronine results in decreased expression of APP more ... CTD PMID:17199430 App Rat 3,3',5-triiodo-L-thyronine multiple interactions EXP 6480464 Triiodothyronine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in more ... CTD PMID:36868496 App Rat 3,3',5-triiodo-L-thyronine multiple interactions ISO RGD:736021 6480464 Tretinoin promotes the reaction [Triiodothyronine results in decreased secretion of APP protein] CTD PMID:17199430 App Rat 3,4-dihydroxybenzoic acid multiple interactions ISO RGD:736021 6480464 Gallic Acid inhibits the reaction [protocatechuic acid inhibits the reaction [APP protein modified form binds more ... CTD PMID:22129351 App Rat 3-chloropropane-1,2-diol decreases expression EXP 6480464 alpha-Chlorohydrin results in decreased expression of APP mRNA CTD PMID:20409345 App Rat 3-methyladenine multiple interactions ISO RGD:736021 6480464 [Hydrogen Peroxide co-treated with 3-methyladenine] results in increased expression of APP protein CTD PMID:23726866 App Rat 3-nitrophenol affects localization ISO RGD:736022 6480464 3-nitrophenol affects the localization of APP protein CTD PMID:18949129 App Rat 3-nitrophenol multiple interactions ISO RGD:736022 6480464 3-nitrophenol affects the reaction [APP protein affects the abundance of Calcium] CTD PMID:18949129 App Rat 3H-1,2-dithiole-3-thione decreases expression EXP 6480464 1,2-dithiol-3-thione results in decreased expression of APP mRNA CTD PMID:19162173 App Rat 4,4'-diaminodiphenylmethane affects expression EXP 6480464 4,4'-diaminodiphenylmethane affects the expression of APP mRNA CTD PMID:25380136 App Rat 4,4'-sulfonyldiphenol decreases expression ISO RGD:736022 6480464 bisphenol S results in decreased expression of APP mRNA CTD PMID:39298647 App Rat 4,4'-sulfonyldiphenol multiple interactions EXP 6480464 [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in decreased expression of more ... CTD PMID:36041667 App Rat 4,7-diphenyl-1,10-phenanthroline increases metabolic processing ISO RGD:736021 6480464 bathophenanthroline results in increased metabolism of APP protein CTD PMID:10940226 App Rat 4-hydroxynon-2-enal multiple interactions ISO RGD:736021 6480464 [[[APP protein modified form binds to Copper] which co-treated with Ascorbic Acid] results in increased more ... CTD PMID:17964426 App Rat 4-hydroxynon-2-enal decreases expression ISO RGD:736021 6480464 4-hydroxy-2-nonenal results in decreased expression of APP mRNA CTD PMID:12419474 App Rat 4-phenylbutyric acid affects activity EXP 6480464 4-phenylbutyric acid affects the activity of APP protein CTD PMID:16204253 App Rat 5,6,7,8-tetrahydrobiopterin multiple interactions ISO RGD:736021 6480464 APP gene mutant form results in increased oxidation of and results in decreased abundance of more ... CTD PMID:22886847 App Rat 5-(beta-D-galactosyloxy)-L-lysine multiple interactions ISO RGD:736022 6480464 [APP protein mutant form co-treated with PSEN1 protein mutant form] results in decreased abundance of more ... CTD PMID:39172838 App Rat 5-azacytidine decreases methylation ISO RGD:736022 6480464 Azacitidine results in decreased methylation of APP promoter CTD PMID:19635394 App Rat 5-azacytidine multiple interactions ISO RGD:736022 6480464 Azacitidine results in increased expression of and results in increased cleavage of APP protein; Betaine more ... CTD PMID:19635394 App Rat 5-chloro-7-iodoquinolin-8-ol multiple interactions ISO RGD:736021 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Clioquinol binds to Copper] which results in increased degradation of APP more ... CTD PMID:16648635|PMID:18346929 App Rat 5-methoxypsoralen multiple interactions ISO RGD:736022 6480464 5-Methoxypsoralen inhibits the reaction [Streptozocin results in increased expression of APP protein modified form] CTD PMID:34428446 App Rat 7,9-dihydro-1H-purine-2,6,8(3H)-trione multiple interactions ISO RGD:736022 6480464 [APP protein mutant form co-treated with PSEN1 protein mutant form] results in decreased abundance of more ... CTD PMID:39172838 App Rat 7alpha-hydroxycholesterol increases chemical synthesis EXP 6480464 APP protein results in increased chemical synthesis of cholest-5-en-3 beta,7 alpha-diol CTD PMID:15591071 App Rat 7alpha-hydroxycholesterol decreases secretion EXP 6480464 cholest-5-en-3 beta,7 alpha-diol results in decreased secretion of APP protein CTD PMID:15591071 App Rat 8-epi-prostaglandin F2alpha increases abundance ISO RGD:736021 6480464 APP protein modified form results in increased abundance of 8-epi-prostaglandin F2alpha CTD PMID:22610977 App Rat 8-epi-prostaglandin F2alpha multiple interactions ISO RGD:736021 6480464 [Lead co-treated with APP protein modified form] results in increased abundance of 8-epi-prostaglandin F2alpha CTD PMID:22610977 App Rat 9-cis-retinoic acid multiple interactions ISO RGD:736021 6480464 Alitretinoin inhibits the reaction [Flurbiprofen results in decreased secretion of APP protein] CTD PMID:19659691 App Rat acetamide increases expression EXP 6480464 acetamide results in increased expression of APP mRNA CTD PMID:31881176 App Rat acetyl-CoA affects localization ISO RGD:736022 6480464 APP protein affects the localization of Acetyl Coenzyme A CTD PMID:16122837 App Rat acetyl-CoA increases secretion ISO RGD:736021 6480464 Acetyl Coenzyme A results in increased secretion of APP protein modified form CTD PMID:22906069 App Rat acetyl-CoA multiple interactions ISO RGD:736021 6480464 Acetyl Coenzyme A inhibits the reaction [Hydrogen Peroxide results in decreased secretion of APP protein more ... CTD PMID:22906069 App Rat acetyl-CoA multiple interactions ISO RGD:736022 6480464 IL1B protein affects the reaction [APP protein affects the localization of Acetyl Coenzyme A] CTD PMID:16122837 App Rat acetylcholine multiple interactions ISO RGD:736022 6480464 [IL1B protein co-treated with APP protein] results in increased secretion of Acetylcholine; IL1B protein inhibits more ... CTD PMID:16122837 App Rat acetylcholine multiple interactions ISO RGD:736021 6480464 GW 501516 inhibits the reaction [APP gene mutant form results in decreased susceptibility to Acetylcholine] CTD PMID:22886847 App Rat acetylcholine decreases secretion ISO RGD:736022 6480464 APP protein results in decreased secretion of Acetylcholine CTD PMID:16122837 App Rat acetylcholine multiple interactions EXP 6480464 APP protein modified form inhibits the reaction [Nicotine results in increased secretion of Acetylcholine]; spiro(imidazo-(1,2-a)pyridine-3,2-indan)-2(3H)-one more ... CTD PMID:16474004 App Rat acetylsalicylic acid multiple interactions ISO RGD:736022 6480464 Aspirin inhibits the reaction [[Benzo(a)pyrene affects the expression of APP protein] which results in increased more ... CTD PMID:37364758 App Rat aconitic acid multiple interactions ISO RGD:736022 6480464 [APP protein mutant form co-treated with PSEN1 protein mutant form] results in decreased abundance of more ... CTD PMID:39172838 App Rat acrolein multiple interactions ISO RGD:736021 6480464 [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased expression of more ... CTD PMID:16081039|PMID:32699268|PMID:32845096 App Rat acrolein increases expression EXP 6480464 Acrolein results in increased expression of APP protein CTD PMID:29355571 App Rat acrolein increases expression ISO RGD:736022 6480464 Acrolein results in increased expression of APP protein CTD PMID:23296102 App Rat acrolein affects binding ISO RGD:736021 6480464 [Acrolein binds to APP protein] binds to [Acrolein binds to APP protein]; Acrolein binds to more ... CTD PMID:16081039 App Rat adenine multiple interactions ISO RGD:736021 6480464 PF-06840003 inhibits the reaction [APP protein mutant form results in decreased abundance of Adenine] CTD PMID:39172838 App Rat adenine decreases abundance ISO RGD:736021 6480464 APP protein mutant form results in decreased abundance of Adenine CTD PMID:39172838 App Rat ADP increases abundance ISO RGD:736021 6480464 APP protein mutant form results in increased abundance of Adenosine Diphosphate CTD PMID:39172838 App Rat ADP multiple interactions ISO RGD:736022 6480464 [APP protein mutant form co-treated with PSEN1 protein mutant form] results in increased abundance of more ... CTD PMID:39172838 App Rat ADP multiple interactions ISO RGD:736021 6480464 PF-06840003 inhibits the reaction [APP protein mutant form results in increased abundance of Adenosine Diphosphate] CTD PMID:39172838 App Rat aflatoxin B1 decreases expression ISO RGD:736022 6480464 Aflatoxin B1 results in decreased expression of APP mRNA CTD PMID:19770486 App Rat aflatoxin B1 increases expression EXP 6480464 Aflatoxin B1 results in increased expression of APP mRNA CTD PMID:22484513|PMID:33354967 App Rat agmatine decreases abundance ISO RGD:736022 6480464 APP protein results in decreased abundance of Agmatine CTD PMID:32522471 App Rat agmatine multiple interactions ISO RGD:736022 6480464 Agmatine inhibits the reaction [APP protein results in decreased expression of BDNF protein]; Agmatine inhibits more ... CTD PMID:32522471 App Rat AICA ribonucleotide decreases expression ISO RGD:736021 6480464 AICA ribonucleotide results in decreased expression of APP protein modified form CTD PMID:20080969 App Rat aldehydo-D-glucose multiple interactions ISO RGD:736021 6480464 PF-06840003 inhibits the reaction [APP protein mutant form results in increased abundance of Glucose] CTD PMID:39172838 App Rat aldehydo-D-glucose increases abundance ISO RGD:736021 6480464 APP protein mutant form results in increased abundance of Glucose CTD PMID:39172838 App Rat aldehydo-D-glucose multiple interactions ISO RGD:736022 6480464 [APP protein mutant form co-treated with PSEN1 protein mutant form co-treated with PF-06840003] results in more ... CTD PMID:39172838 App Rat aldicarb decreases response to substance ISO RGD:736021 6480464 APP protein modified form results in decreased susceptibility to Aldicarb CTD PMID:34902447 App Rat alendronic acid multiple interactions ISO RGD:736022 6480464 Alendronate inhibits the reaction [Streptozocin results in increased expression of APP protein] CTD PMID:30481507 App Rat all-trans-retinoic acid multiple interactions ISO RGD:736021 6480464 [BDNF protein co-treated with Tretinoin] results in increased expression of APP protein; Aluminum Hydroxide promotes more ... CTD PMID:16150056|PMID:17199430|PMID:19476501|PMID:37989595 App Rat all-trans-retinoic acid multiple interactions EXP 6480464 Tretinoin inhibits the reaction [Vitamin A affects the expression of APP mRNA] CTD PMID:16530976 App Rat all-trans-retinoic acid increases secretion ISO RGD:736021 6480464 Tretinoin results in increased secretion of APP protein modified form CTD PMID:19476501 App Rat all-trans-retinoic acid increases expression ISO RGD:736021 6480464 Tretinoin results in increased expression of APP protein CTD PMID:16150056 App Rat all-trans-retinol increases expression EXP 6480464 Vitamin A results in increased expression of APP protein CTD PMID:22274401 App Rat all-trans-retinol affects expression EXP 6480464 Vitamin A affects the expression of APP mRNA CTD PMID:16530976 App Rat all-trans-retinol multiple interactions EXP 6480464 Tretinoin inhibits the reaction [Vitamin A affects the expression of APP mRNA] CTD PMID:16530976 App Rat alpha-D-galactose multiple interactions ISO RGD:736022 6480464 [Galactose co-treated with Aluminum Chloride] results in decreased expression of APP protein; astragalin inhibits the more ... CTD PMID:35537655 App Rat alpha-hexachlorocyclohexane increases expression EXP 6480464 alpha-hexachlorocyclohexane results in increased expression of APP mRNA CTD PMID:17785943 App Rat alpha-mangostin multiple interactions ISO RGD:736021 6480464 mangostin inhibits the reaction [APP protein binds to APP protein] CTD PMID:38552766 App Rat alpha-pinene multiple interactions ISO RGD:736021 6480464 [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased expression of more ... CTD PMID:32699268 App Rat aluminium atom multiple interactions EXP 6480464 [Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of APP mRNA; Berberine more ... CTD PMID:29170048 App Rat aluminium atom increases expression ISO RGD:736021 6480464 Aluminum results in increased expression of APP mRNA CTD PMID:16308480 App Rat aluminium atom multiple interactions ISO RGD:736022 6480464 APP protein promotes the reaction [Aluminum results in decreased activity of CHAT protein]; meloxicam inhibits more ... CTD PMID:12039845|PMID:16724269|PMID:16928369 App Rat aluminium atom increases expression ISO RGD:736022 6480464 Aluminum results in increased expression of APP protein CTD PMID:16928369 App Rat aluminium atom increases cleavage ISO RGD:736022 6480464 Aluminum results in increased cleavage of APP protein CTD PMID:12039845 App Rat aluminium atom affects binding ISO RGD:736021 6480464 APP protein binds to Aluminum CTD PMID:16942756 App Rat aluminium atom multiple interactions ISO RGD:736021 6480464 [APP protein modified form binds to Aluminum] which results in increased expression of RCVRN mRNA CTD PMID:21298039 App Rat aluminium hydroxide increases expression ISO RGD:736021 6480464 Aluminum Hydroxide results in increased expression of APP protein CTD PMID:37989595 App Rat aluminium hydroxide multiple interactions ISO RGD:736021 6480464 Aluminum Hydroxide promotes the reaction [[BDNF protein co-treated with Tretinoin] results in increased expression of more ... CTD PMID:37989595 App Rat aluminium sulfate (anhydrous) increases expression ISO RGD:736021 6480464 aluminum sulfate results in increased expression of APP mRNA CTD PMID:15961160 App Rat aluminium sulfate (anhydrous) affects expression ISO RGD:736022 6480464 aluminum sulfate affects the expression of APP protein CTD PMID:10721010 App Rat aluminium(0) multiple interactions ISO RGD:736021 6480464 [APP protein modified form binds to Aluminum] which results in increased expression of RCVRN mRNA CTD PMID:21298039 App Rat aluminium(0) increases expression ISO RGD:736021 6480464 Aluminum results in increased expression of APP mRNA CTD PMID:16308480 App Rat aluminium(0) multiple interactions ISO RGD:736022 6480464 APP protein promotes the reaction [Aluminum results in decreased activity of CHAT protein]; meloxicam inhibits more ... CTD PMID:12039845|PMID:16724269|PMID:16928369 App Rat aluminium(0) increases expression ISO RGD:736022 6480464 Aluminum results in increased expression of APP protein CTD PMID:16928369 App Rat aluminium(0) increases cleavage ISO RGD:736022 6480464 Aluminum results in increased cleavage of APP protein CTD PMID:12039845 App Rat aluminium(0) affects binding ISO RGD:736021 6480464 APP protein binds to Aluminum CTD PMID:16942756 App Rat aluminium(0) multiple interactions EXP 6480464 [Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of APP mRNA; Berberine more ... CTD PMID:29170048 App Rat ambenonium chloride affects cleavage EXP 6480464 Ambenonium Chloride affects the cleavage of APP protein CTD PMID:11099780 App Rat aminoguanidine multiple interactions ISO RGD:736021 6480464 pimagedine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of APP more ... CTD PMID:28242320 App Rat amitrole affects activity EXP 6480464 Amitrole affects the activity of APP protein CTD PMID:16204253 App Rat ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of APP mRNA CTD PMID:16483693 App Rat ammonium chloride decreases expression EXP 6480464 Ammonium Chloride results in decreased expression of APP protein CTD PMID:16483693 App Rat anandamide decreases response to substance EXP 6480464 anandamide results in decreased susceptibility to APP protein CTD PMID:22233683 App Rat anandamide decreases metabolic processing ISO RGD:736022 6480464 APP protein results in decreased metabolism of anandamide CTD PMID:26976670 App Rat anandamide decreases abundance ISO RGD:736022 6480464 APP protein results in decreased abundance of anandamide CTD PMID:26976670 App Rat anthra[1,9-cd]pyrazol-6(2H)-one multiple interactions ISO RGD:736021 6480464 pyrazolanthrone inhibits the reaction [[Clioquinol co-treated with Copper] results in decreased expression of APP protein more ... CTD PMID:16648635|PMID:28004443 App Rat arachidonic acid increases secretion ISO RGD:736021 6480464 APP protein modified form results in increased secretion of Arachidonic Acid CTD PMID:28721267 App Rat arachidonic acid multiple interactions ISO RGD:736021 6480464 [1,1,1,2,2-pentafluoro-7-phenylheptan-3-one co-treated with Orlistat] inhibits the reaction [APP protein modified form results in increased secretion more ... CTD PMID:28721267 App Rat aristolochic acid A decreases expression ISO RGD:736021 6480464 aristolochic acid I results in decreased expression of APP mRNA; aristolochic acid I results in more ... CTD PMID:33212167 App Rat Aroclor 1254 decreases expression ISO RGD:736022 6480464 Chlorodiphenyl (54% Chlorine) results in decreased expression of APP mRNA CTD PMID:23650126 App Rat arsane increases cleavage EXP 6480464 Arsenic results in increased cleavage of APP protein CTD PMID:29155576 App Rat arsane multiple interactions ISO RGD:736021 6480464 [arsenic trichloride results in increased abundance of Arsenic] which results in decreased expression of APP more ... CTD PMID:33736254|PMID:35809665 App Rat arsane increases expression EXP 6480464 Arsenic results in increased expression of APP protein; Arsenic results in increased expression of APP more ... CTD PMID:25288670|PMID:29155576 App Rat arsane multiple interactions EXP 6480464 [Arsenic co-treated with Cadmium co-treated with Lead] promotes the reaction [BACE1 protein results in increased more ... CTD PMID:25288670 App Rat arsane affects methylation ISO RGD:736021 6480464 Arsenic affects the methylation of APP gene CTD PMID:25304211 App Rat arsenic atom increases cleavage EXP 6480464 Arsenic results in increased cleavage of APP protein CTD PMID:29155576 App Rat arsenic atom multiple interactions ISO RGD:736021 6480464 [arsenic trichloride results in increased abundance of Arsenic] which results in decreased expression of APP more ... CTD PMID:33736254|PMID:35809665 App Rat arsenic atom increases expression EXP 6480464 Arsenic results in increased expression of APP protein; Arsenic results in increased expression of APP more ... CTD PMID:25288670|PMID:29155576 App Rat arsenic atom multiple interactions EXP 6480464 [Arsenic co-treated with Cadmium co-treated with Lead] promotes the reaction [BACE1 protein results in increased more ... CTD PMID:25288670 App Rat arsenic atom affects methylation ISO RGD:736021 6480464 Arsenic affects the methylation of APP gene CTD PMID:25304211 App Rat arsenic trichloride multiple interactions ISO RGD:736021 6480464 [arsenic trichloride results in increased abundance of Arsenic] which results in decreased expression of APP more ... CTD PMID:35809665 App Rat arsenous acid increases expression ISO RGD:736021 6480464 Arsenic Trioxide results in increased expression of APP mRNA CTD PMID:20458559 App Rat astaxanthin multiple interactions ISO RGD:736022 6480464 astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of APP mRNA] CTD PMID:16964424 App Rat atorvastatin calcium multiple interactions ISO RGD:736022 6480464 Atorvastatin inhibits the reaction [APP protein results in decreased expression of SLC1A2 protein]; Atorvastatin inhibits more ... CTD PMID:20816828 App Rat ATP multiple interactions ISO RGD:736021 6480464 Adenosine Triphosphate inhibits the reaction [Hydrogen Peroxide results in decreased secretion of APP protein modified more ... CTD PMID:22906069 App Rat ATP multiple interactions ISO RGD:736022 6480464 [APP protein mutant form co-treated with PSEN1 protein mutant form] results in decreased abundance of more ... CTD PMID:39172838 App Rat ATP increases secretion ISO RGD:736021 6480464 Adenosine Triphosphate results in increased secretion of APP protein modified form CTD PMID:22906069 App Rat atrazine affects methylation EXP 6480464 Atrazine affects the methylation of APP gene CTD PMID:28931070 App Rat Azoxymethane multiple interactions ISO RGD:736022 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of APP more ... CTD PMID:29950665 App Rat azure B multiple interactions ISO RGD:736021 6480464 [Azure B affects the cleavage of APP protein] which results in decreased secretion of APP more ... CTD PMID:30500345 App Rat baicalein multiple interactions EXP 6480464 baicalein inhibits the reaction [APP protein binds to APP protein] CTD PMID:17323972 App Rat benzene multiple interactions ISO RGD:736021 6480464 Benzene analog inhibits the reaction [APP protein binds to APP protein] CTD PMID:15707952 App Rat benzene affects binding ISO RGD:736021 6480464 Benzene analog binds to APP protein CTD PMID:15707952 App Rat benzo[a]pyrene decreases expression ISO RGD:736022 6480464 Benzo(a)pyrene results in decreased expression of APP mRNA CTD PMID:19770486 App Rat benzo[a]pyrene affects expression ISO RGD:736022 6480464 Benzo(a)pyrene affects the expression of APP protein CTD PMID:37364758 App Rat benzo[a]pyrene decreases methylation ISO RGD:736021 6480464 Benzo(a)pyrene results in decreased methylation of APP 3' UTR CTD PMID:27901495 App Rat benzo[a]pyrene increases expression ISO RGD:736021 6480464 Benzo(a)pyrene results in increased expression of APP mRNA; Benzo(a)pyrene results in increased expression of APP more ... CTD PMID:22316170|PMID:25596431 App Rat benzo[a]pyrene multiple interactions ISO RGD:736022 6480464 [Benzo(a)pyrene affects the expression of APP protein] which results in increased abundance of amyloid beta-protein more ... CTD PMID:19654925|PMID:37364758 App Rat berberine multiple interactions EXP 6480464 Berberine inhibits the reaction [[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression more ... CTD PMID:29170048 App Rat Bergenin multiple interactions EXP 6480464 bergenin affects the reaction [Sodium Azide results in increased expression of APP protein]; bisphenol A more ... CTD PMID:36249784 App Rat beta-D-fructofuranose 1,6-bisphosphate multiple interactions ISO RGD:736022 6480464 [APP protein mutant form co-treated with PSEN1 protein mutant form] results in decreased abundance of more ... CTD PMID:39172838 App Rat beta-D-fructofuranose 1,6-bisphosphate decreases abundance ISO RGD:736021 6480464 APP protein mutant form results in decreased abundance of fructose-1,6-diphosphate CTD PMID:39172838 App Rat beta-D-fructofuranose 1,6-bisphosphate multiple interactions ISO RGD:736021 6480464 PF-06840003 inhibits the reaction [APP protein mutant form results in decreased abundance of fructose-1,6-diphosphate] CTD PMID:39172838 App Rat beta-lapachone decreases expression ISO RGD:736021 6480464 beta-lapachone results in decreased expression of APP mRNA CTD PMID:38218311 App Rat bethanechol increases secretion EXP 6480464 Bethanechol results in increased secretion of APP protein modified form CTD PMID:7605915|PMID:8624119 App Rat bexarotene increases expression EXP 6480464 bexarotene results in increased expression of APP mRNA CTD PMID:16648578 App Rat bilobalide multiple interactions ISO RGD:736021 6480464 bilobalide inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein] CTD PMID:18001288 App Rat biotin multiple interactions EXP 6480464 [Biotin co-treated with coenzyme Q10] inhibits the reaction [Aluminum Chloride results in increased expression of more ... CTD PMID:32383521 App Rat bis(2-chloroethyl) sulfide decreases expression ISO RGD:736022 6480464 Mustard Gas results in decreased expression of APP mRNA CTD PMID:15674843 App Rat bis(2-ethylhexyl) phthalate increases expression ISO RGD:736022 6480464 Diethylhexyl Phthalate results in increased expression of APP mRNA CTD PMID:33162236 App Rat bis(2-ethylhexyl) phthalate decreases expression ISO RGD:736022 6480464 Diethylhexyl Phthalate results in decreased expression of APP mRNA CTD PMID:33754040 App Rat bisdemethoxycurcumin multiple interactions ISO RGD:736021 6480464 [bisdemethoxycurcumin analog co-treated with APP protein] results in increased expression of MGAT3 mRNA; [bisdemethoxycurcumin analog more ... CTD PMID:19715544|PMID:22029407 App Rat bisphenol A increases expression ISO RGD:736022 6480464 bisphenol A results in increased expression of APP mRNA; bisphenol A results in increased expression more ... CTD PMID:26063408|PMID:26779933|PMID:26923231 App Rat bisphenol A multiple interactions EXP 6480464 [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in decreased expression of more ... CTD PMID:36041667 App Rat bisphenol A decreases methylation ISO RGD:736021 6480464 bisphenol A results in decreased methylation of APP gene CTD PMID:31601247 App Rat bisphenol A multiple interactions ISO RGD:736021 6480464 [bisphenol A co-treated with Fulvestrant] results in decreased methylation of APP gene CTD PMID:31601247 App Rat bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of APP mRNA CTD PMID:34947998 App Rat bisphenol A decreases expression ISO RGD:736021 6480464 bisphenol A results in decreased expression of APP protein CTD PMID:37567409 App Rat bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of APP mRNA; bisphenol A results in increased expression more ... CTD PMID:25181051|PMID:35648353 App Rat Bisphenol A diglycidyl ether multiple interactions EXP 6480464 bisphenol A diglycidyl ether affects the reaction [bergenin affects the reaction [Sodium Azide results in more ... CTD PMID:36249784 App Rat bisphenol F decreases expression EXP 6480464 4,4'-bisphenol F results in decreased expression of APP mRNA CTD PMID:26186136 App Rat bisphenol F multiple interactions EXP 6480464 [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in decreased expression of more ... CTD PMID:36041667 App Rat bisphenol F multiple interactions ISO RGD:736021 6480464 [bisphenol F co-treated with Fulvestrant] results in decreased methylation of APP gene CTD PMID:31601247 App Rat buspirone decreases expression EXP 6480464 Buspirone results in decreased expression of APP mRNA CTD PMID:24136188 App Rat buten-2-one multiple interactions ISO RGD:736021 6480464 [3-buten-2-one results in increased metabolism of APP protein] which results in increased secretion of APP more ... CTD PMID:29618714 App Rat cadmium atom affects binding ISO RGD:736021 6480464 Cadmium binds to APP protein CTD PMID:16266835 App Rat cadmium atom multiple interactions ISO RGD:736021 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of APP more ... CTD PMID:29741670 App Rat cadmium atom increases expression EXP 6480464 Cadmium results in increased expression of APP protein CTD PMID:25288670 App Rat cadmium atom multiple interactions EXP 6480464 [Arsenic co-treated with Cadmium co-treated with Lead] promotes the reaction [BACE1 protein results in increased more ... CTD PMID:25288670|PMID:29170048|PMID:36868496 App Rat cadmium dichloride multiple interactions ISO RGD:736022 6480464 [[Cadmium Chloride results in decreased activity of CHRM1 protein] which affects the expression of ACHE more ... CTD PMID:19840844|PMID:26026611|PMID:27377441|PMID:30213552 App Rat cadmium dichloride multiple interactions EXP 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of APP more ... CTD PMID:36868496 App Rat cadmium dichloride multiple interactions ISO RGD:736021 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of APP more ... CTD PMID:29741670 App Rat cadmium dichloride increases expression ISO RGD:736022 6480464 Cadmium Chloride results in increased expression of APP protein; Cadmium Chloride results in increased expression more ... CTD PMID:26026611|PMID:27377441|PMID:30213552 App Rat calcium atom multiple interactions ISO RGD:736022 6480464 2,4-Dinitrophenol affects the reaction [APP protein affects the abundance of Calcium]; 3-nitrophenol affects the reaction more ... CTD PMID:18949129 App Rat calcium atom increases uptake EXP 6480464 APP protein modified form results in increased uptake of Calcium; APP protein results in increased more ... CTD PMID:12383957|PMID:18648507|PMID:24457011 App Rat calcium atom multiple interactions EXP 6480464 Calcium deficiency inhibits the reaction [APP protein modified form results in increased uptake of Calcium]; more ... CTD PMID:12383957|PMID:18648507|PMID:24457011 App Rat calcium atom affects abundance ISO RGD:736022 6480464 APP protein affects the abundance of Calcium CTD PMID:18949129 App Rat calcium(0) multiple interactions ISO RGD:736022 6480464 2,4-Dinitrophenol affects the reaction [APP protein affects the abundance of Calcium]; 3-nitrophenol affects the reaction more ... CTD PMID:18949129 App Rat calcium(0) increases uptake EXP 6480464 APP protein modified form results in increased uptake of Calcium; APP protein results in increased more ... CTD PMID:12383957|PMID:18648507|PMID:24457011 App Rat calcium(0) multiple interactions EXP 6480464 Calcium deficiency inhibits the reaction [APP protein modified form results in increased uptake of Calcium]; more ... CTD PMID:12383957|PMID:18648507|PMID:24457011 App Rat calcium(0) affects abundance ISO RGD:736022 6480464 APP protein affects the abundance of Calcium CTD PMID:18949129 App Rat calycosin multiple interactions EXP 6480464 7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [Glycation End Products, Advanced results in increased expression of APP protein] CTD PMID:36195188 App Rat cannabidiol multiple interactions ISO RGD:736022 6480464 Cannabidiol inhibits the reaction [APP alternative form results in increased expression of IL6 mRNA] CTD PMID:21350020 App Rat cannabidiol multiple interactions ISO RGD:736021 6480464 [Cannabidiol co-treated with moringin] results in decreased expression of APP mRNA; [Dronabinol co-treated with Cannabidiol] more ... CTD PMID:27567873|PMID:30096889 App Rat carbachol multiple interactions ISO RGD:736022 6480464 Carbachol inhibits the reaction [APP protein modified form results in decreased expression of BCL2 protein]; more ... CTD PMID:10758335 App Rat carbon nanotube affects expression ISO RGD:736022 6480464 Nanotubes, Carbon affects the expression of APP mRNA CTD PMID:23845593 App Rat carbon nanotube increases expression ISO RGD:736021 6480464 Nanotubes, Carbon results in increased expression of APP mRNA CTD PMID:24389112 App Rat carbon nanotube decreases expression ISO RGD:736022 6480464 Nanotubes, Carbon analog results in decreased expression of APP mRNA; Nanotubes, Carbon results in decreased more ... CTD PMID:25554681 App Rat carnosine decreases expression ISO RGD:736022 6480464 Carnosine results in decreased expression of APP protein modified form CTD PMID:21423579 App Rat carvedilol decreases expression ISO RGD:736022 6480464 carvedilol results in decreased expression of APP protein modified form CTD PMID:20579773 App Rat celecoxib affects cleavage ISO RGD:736022 6480464 Celecoxib affects the cleavage of APP protein CTD PMID:14690522 App Rat chloropicrin decreases expression ISO RGD:736021 6480464 chloropicrin results in decreased expression of APP mRNA CTD PMID:28476498 App Rat chloropicrin affects expression ISO RGD:736021 6480464 chloropicrin affects the expression of APP mRNA CTD PMID:26352163 App Rat chloroquine affects expression EXP 6480464 Chloroquine affects the expression of APP mRNA; Chloroquine affects the expression of APP protein CTD PMID:9690670 App Rat chloroquine increases expression EXP 6480464 Chloroquine results in increased expression of APP protein CTD PMID:8616629 App Rat chloroquine affects localization EXP 6480464 Chloroquine affects the localization of APP protein CTD PMID:7715800 App Rat chloroquine multiple interactions EXP 6480464 Chloroquine affects the localization of and affects the cleavage of APP protein CTD PMID:8787835 App Rat chlorpyrifos increases expression ISO RGD:736022 6480464 Chlorpyrifos results in increased expression of APP mRNA; Chlorpyrifos results in increased expression of APP more ... CTD PMID:29665406|PMID:37019170 App Rat cholesterol multiple interactions ISO RGD:736022 6480464 [Copper co-treated with Cholesterol] results in increased expression of APP mRNA CTD PMID:17134702 App Rat cholesterol increases oxidation EXP 6480464 APP protein results in increased oxidation of Cholesterol CTD PMID:15591071 App Rat choline multiple interactions ISO RGD:736022 6480464 [APP protein mutant form co-treated with PSEN1 protein mutant form] results in decreased abundance of more ... CTD PMID:20938992|PMID:39172838 App Rat cilostazol affects expression ISO RGD:736022 6480464 cilostazol affects the expression of APP protein CTD PMID:24254769 App Rat cilostazol multiple interactions ISO RGD:736022 6480464 (E)-3-(2,3,4,5-tetrabromophenyl)acrylic acid inhibits the reaction [cilostazol inhibits the reaction [APP protein results in decreased expression more ... CTD PMID:24254769 App Rat cis-caffeic acid multiple interactions ISO RGD:736022 6480464 caffeic acid inhibits the reaction [aluminum chloride results in increased expression of APP protein modified more ... CTD PMID:18482095 App Rat citric acid decreases abundance ISO RGD:736021 6480464 APP protein mutant form results in decreased abundance of Citric Acid CTD PMID:39172838 App Rat citric acid multiple interactions ISO RGD:736021 6480464 PF-06840003 inhibits the reaction [APP protein mutant form results in decreased abundance of Citric Acid] CTD PMID:39172838 App Rat citric acid multiple interactions ISO RGD:736022 6480464 [APP protein mutant form co-treated with PSEN1 protein mutant form] results in decreased abundance of more ... CTD PMID:39172838 App Rat clofibrate decreases expression EXP 6480464 Clofibrate results in decreased expression of APP mRNA CTD PMID:15093671 App Rat clofibric acid multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of APP mRNA CTD PMID:17602206 App Rat clozapine increases expression ISO RGD:736021 6480464 Clozapine results in increased expression of APP protein CTD PMID:36482696 App Rat cobalt atom increases secretion ISO RGD:736021 6480464 Cobalt results in increased secretion of APP protein modified form CTD PMID:12182891 App Rat cobalt atom multiple interactions ISO RGD:736021 6480464 Estradiol inhibits the reaction [Cobalt results in increased secretion of APP protein modified form] CTD PMID:12182891 App Rat cobalt dichloride decreases expression ISO RGD:736021 6480464 cobaltous chloride results in decreased expression of APP mRNA CTD PMID:19320972 App Rat cocaine decreases expression EXP 6480464 Cocaine results in decreased expression of APP mRNA CTD PMID:17898221 App Rat cocaine increases expression ISO RGD:736021 6480464 Cocaine results in increased expression of APP mRNA CTD PMID:15009677|PMID:16710320 App Rat coenzyme Q10 decreases response to substance EXP 6480464 coenzyme Q10 results in decreased susceptibility to APP protein CTD PMID:22186599 App Rat coenzyme Q10 multiple interactions EXP 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [coenzyme Q10 results in decreased susceptibility to APP protein]; [Biotin co-treated more ... CTD PMID:22186599|PMID:32383521 App Rat Congo Red multiple interactions EXP 6480464 Congo Red inhibits the reaction [APP protein binds to APP protein] CTD PMID:17323972 App Rat Congo Red affects binding ISO RGD:736021 6480464 Congo Red binds to APP protein CTD PMID:17406451 App Rat copper atom multiple interactions ISO RGD:736021 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Clioquinol binds to Copper] which results in increased degradation of APP more ... CTD PMID:11784781|PMID:12572668|PMID:15699049|PMID:16325427|PMID:16627626|PMID:16648635|PMID:16962711|PMID:17964426|PMID:18346929|PMID:18583042|PMID:19122148|PMID:21706413|PMID:24276282|PMID:24610780|PMID:24690739|PMID:25835329 App Rat copper atom decreases expression ISO RGD:736021 6480464 Copper deficiency results in decreased expression of APP mRNA; Copper deficiency results in decreased expression more ... CTD PMID:14985339|PMID:18248325 App Rat copper atom increases response to substance ISO RGD:736021 6480464 APP protein results in increased susceptibility to Copper CTD PMID:11784781 App Rat copper atom increases reduction ISO RGD:736021 6480464 APP protein modified form results in increased reduction of Copper; APP protein results in increased more ... CTD PMID:12572668 App Rat copper atom decreases abundance ISO RGD:736022 6480464 APP protein results in decreased abundance of Copper CTD PMID:12611883 App Rat copper atom increases degradation ISO RGD:736021 6480464 Copper results in increased degradation of APP protein modified form CTD PMID:18068270 App Rat copper atom increases expression ISO RGD:736021 6480464 Copper deficiency results in increased expression of APP protein modified form; Copper results in increased more ... CTD PMID:16627626|PMID:16962711|PMID:18248325|PMID:18583042|PMID:25305487 App Rat copper atom affects cleavage ISO RGD:736021 6480464 Copper affects the cleavage of APP protein CTD PMID:18248325 App Rat copper atom increases expression ISO RGD:736022 6480464 Copper results in increased expression of APP protein CTD PMID:16886094 App Rat copper atom multiple interactions ISO RGD:736022 6480464 [APP gene mutant form co-treated with PSEN1 gene mutant form] results in increased abundance of more ... CTD PMID:15467011|PMID:15677459|PMID:17134702|PMID:23541064|PMID:25352456|PMID:27122238 App Rat copper atom increases secretion ISO RGD:736022 6480464 APP protein results in increased secretion of Copper CTD PMID:16866297 App Rat copper atom increases secretion ISO RGD:736021 6480464 Copper deficiency results in increased secretion of APP protein modified form; Copper results in increased more ... CTD PMID:16648635|PMID:16962711|PMID:18248325 App Rat copper atom affects binding ISO RGD:736021 6480464 APP protein binds to Copper; APP protein modified form binds to Copper; Copper binds to more ... CTD PMID:15699049|PMID:16404590|PMID:17119284|PMID:17239395|PMID:21980910|PMID:22270944|PMID:24276282|PMID:24855651|PMID:25835329 App Rat copper(0) affects binding ISO RGD:736021 6480464 APP protein binds to Copper; APP protein modified form binds to Copper; Copper binds to more ... CTD PMID:15699049|PMID:16404590|PMID:17119284|PMID:17239395|PMID:21980910|PMID:22270944|PMID:24276282|PMID:24855651|PMID:25835329 App Rat copper(0) decreases expression ISO RGD:736021 6480464 Copper deficiency results in decreased expression of APP mRNA; Copper deficiency results in decreased expression more ... CTD PMID:14985339|PMID:18248325 App Rat copper(0) increases response to substance ISO RGD:736021 6480464 APP protein results in increased susceptibility to Copper CTD PMID:11784781 App Rat copper(0) increases reduction ISO RGD:736021 6480464 APP protein modified form results in increased reduction of Copper; APP protein results in increased more ... CTD PMID:12572668 App Rat copper(0) decreases abundance ISO RGD:736022 6480464 APP protein results in decreased abundance of Copper CTD PMID:12611883 App Rat copper(0) increases degradation ISO RGD:736021 6480464 Copper results in increased degradation of APP protein modified form CTD PMID:18068270 App Rat copper(0) increases expression ISO RGD:736021 6480464 Copper deficiency results in increased expression of APP protein modified form; Copper results in increased more ... CTD PMID:16627626|PMID:16962711|PMID:18248325|PMID:18583042|PMID:25305487 App Rat copper(0) affects cleavage ISO RGD:736021 6480464 Copper affects the cleavage of APP protein CTD PMID:18248325 App Rat copper(0) increases expression ISO RGD:736022 6480464 Copper results in increased expression of APP protein CTD PMID:16886094 App Rat copper(0) multiple interactions ISO RGD:736022 6480464 [APP gene mutant form co-treated with PSEN1 gene mutant form] results in increased abundance of more ... CTD PMID:15467011|PMID:15677459|PMID:17134702|PMID:23541064|PMID:25352456|PMID:27122238 App Rat copper(0) increases secretion ISO RGD:736022 6480464 APP protein results in increased secretion of Copper CTD PMID:16866297 App Rat copper(0) increases secretion ISO RGD:736021 6480464 Copper deficiency results in increased secretion of APP protein modified form; Copper results in increased more ... CTD PMID:16648635|PMID:16962711|PMID:18248325 App Rat copper(0) multiple interactions ISO RGD:736021 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Clioquinol binds to Copper] which results in increased degradation of APP more ... CTD PMID:11784781|PMID:12572668|PMID:15699049|PMID:16325427|PMID:16627626|PMID:16648635|PMID:16962711|PMID:17964426|PMID:18346929|PMID:18583042|PMID:19122148|PMID:21706413|PMID:24276282|PMID:24610780|PMID:24690739|PMID:25835329 App Rat copper(II) chloride increases expression EXP 6480464 cupric chloride results in increased expression of APP mRNA; cupric chloride results in increased expression more ... CTD PMID:22542740 App Rat copper(II) chloride multiple interactions ISO RGD:736022 6480464 cupric chloride results in decreased uptake of and results in decreased degradation of APP protein more ... CTD PMID:32512069 App Rat copper(II) chloride multiple interactions EXP 6480464 cupric chloride results in decreased uptake of and results in decreased degradation of APP protein more ... CTD PMID:32512069 App Rat cordycepin multiple interactions EXP 6480464 1,3-dipropyl-8-cyclopentylxanthine inhibits the reaction [cordycepin inhibits the reaction [APP protein modified form results in increased more ... CTD PMID:30031108 App Rat corosolic acid increases expression ISO RGD:736021 6480464 corosolic acid results in increased expression of APP mRNA CTD PMID:37939859 App Rat coumestrol decreases expression ISO RGD:736021 6480464 Coumestrol results in decreased expression of APP mRNA CTD PMID:19167446 App Rat creatine increases secretion ISO RGD:736021 6480464 Creatine analog results in increased secretion of APP protein modified form CTD PMID:22906069 App Rat crocidolite asbestos increases expression ISO RGD:736021 6480464 Asbestos, Crocidolite results in increased expression of APP protein CTD PMID:29553831 App Rat CTP increases secretion ISO RGD:736021 6480464 Cytidine Triphosphate results in increased secretion of APP protein modified form CTD PMID:22906069 App Rat curcumin multiple interactions ISO RGD:736021 6480464 Curcumin affects the reaction [APP protein binds to APP protein]; Curcumin inhibits the reaction [Copper more ... CTD PMID:18537544|PMID:18583042|PMID:27793699|PMID:31521693 App Rat curcumin multiple interactions EXP 6480464 [Curcumin analog co-treated with APP protein modified form] results in increased expression of NFE2L2 protein; more ... CTD PMID:30946834 App Rat curcumin increases expression ISO RGD:736021 6480464 Curcumin results in increased expression of APP mRNA CTD PMID:31521693 App Rat cyclosporin A decreases expression ISO RGD:736021 6480464 Cyclosporine results in decreased expression of APP mRNA CTD PMID:30008028 App Rat cyprodinil affects binding ISO RGD:736021 6480464 cyprodinil binds to APP protein modified form CTD PMID:31939705 App Rat cyprodinil multiple interactions ISO RGD:736021 6480464 [APP gene mutant form results in increased expression of APP protein modified form] which results more ... CTD PMID:31939705 App Rat D-fructofuranose 1,6-bisphosphate decreases abundance ISO RGD:736021 6480464 APP protein mutant form results in decreased abundance of fructose-1,6-diphosphate CTD PMID:39172838 App Rat D-fructofuranose 1,6-bisphosphate multiple interactions ISO RGD:736022 6480464 [APP protein mutant form co-treated with PSEN1 protein mutant form] results in decreased abundance of more ... CTD PMID:39172838 App Rat D-fructofuranose 1,6-bisphosphate multiple interactions ISO RGD:736021 6480464 PF-06840003 inhibits the reaction [APP protein mutant form results in decreased abundance of fructose-1,6-diphosphate] CTD PMID:39172838 App Rat D-gluconic acid multiple interactions ISO RGD:736022 6480464 [APP protein mutant form co-treated with PSEN1 protein mutant form] results in decreased abundance of more ... CTD PMID:39172838 App Rat D-glucopyranose 6-phosphate decreases abundance ISO RGD:736021 6480464 APP protein mutant form results in decreased abundance of Glucose-6-Phosphate CTD PMID:39172838 App Rat D-glucopyranose 6-phosphate multiple interactions ISO RGD:736021 6480464 PF-06840003 inhibits the reaction [APP protein mutant form results in decreased abundance of Glucose-6-Phosphate] CTD PMID:39172838 App Rat D-glucopyranose 6-phosphate multiple interactions ISO RGD:736022 6480464 [APP protein mutant form co-treated with PSEN1 protein mutant form] results in decreased abundance of more ... CTD PMID:39172838 App Rat D-glucose multiple interactions ISO RGD:736021 6480464 PF-06840003 inhibits the reaction [APP protein mutant form results in increased abundance of Glucose] CTD PMID:39172838 App Rat D-glucose increases abundance ISO RGD:736021 6480464 APP protein mutant form results in increased abundance of Glucose CTD PMID:39172838 App Rat D-glucose multiple interactions ISO RGD:736022 6480464 [APP protein mutant form co-treated with PSEN1 protein mutant form co-treated with PF-06840003] results in more ... CTD PMID:39172838 App Rat D-penicillamine multiple interactions ISO RGD:736021 6480464 Penicillamine inhibits the reaction [[[[APP protein modified form binds to Copper] which co-treated with Ascorbic more ... CTD PMID:12963085|PMID:17964426 App Rat D-penicillamine increases metabolic processing ISO RGD:736021 6480464 Penicillamine results in increased metabolism of APP protein CTD PMID:10940226 App Rat DAPT multiple interactions ISO RGD:736021 6480464 N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Tunicamycin results in increased secretion of APP protein modified more ... CTD PMID:22115781 App Rat DDE increases expression ISO RGD:736021 6480464 Dichlorodiphenyl Dichloroethylene results in increased expression of APP protein CTD PMID:24473795 App Rat DDE decreases expression ISO RGD:736021 6480464 Dichlorodiphenyl Dichloroethylene results in decreased expression of APP mRNA CTD PMID:38568856 App Rat DDT increases expression ISO RGD:736021 6480464 DDT results in increased expression of APP mRNA; DDT results in increased expression of APP more ... CTD PMID:24473795|PMID:25720399|PMID:35946953 App Rat DDT affects expression ISO RGD:736022 6480464 DDT affects the expression of APP mRNA CTD PMID:35946953 App Rat DDT multiple interactions ISO RGD:736022 6480464 Tetrodotoxin inhibits the reaction [DDT results in increased expression of APP mRNA]; Tetrodotoxin inhibits the more ... CTD PMID:35946953 App Rat DDT increases expression ISO RGD:736022 6480464 DDT results in increased expression of APP mRNA; DDT results in increased expression of APP more ... CTD PMID:35946953 App Rat DDT multiple interactions ISO RGD:736021 6480464 DDT results in increased expression of and results in increased cleavage of APP protein mutant more ... CTD PMID:25720399|PMID:35946953 App Rat decabromodiphenyl ether increases expression EXP 6480464 decabromobiphenyl ether results in increased expression of APP mRNA CTD PMID:32679240 App Rat decabromodiphenyl ether increases secretion ISO RGD:736021 6480464 decabromobiphenyl ether results in increased secretion of APP protein modified form CTD PMID:22485137 App Rat demethoxycurcumin decreases secretion ISO RGD:736021 6480464 demethoxycurcumin results in decreased secretion of APP protein CTD PMID:19715544 App Rat demethoxycurcumin multiple interactions ISO RGD:736021 6480464 demethoxycurcumin inhibits the reaction [APP protein binds to APP protein] CTD PMID:19715544 App Rat desferrioxamine B affects binding ISO RGD:736021 6480464 Deferoxamine binds to APP 5' UTR CTD PMID:15681799 App Rat desferrioxamine B multiple interactions ISO RGD:736021 6480464 [Deferoxamine binds to APP 5' UTR] which results in decreased expression of APP protein; [Deferoxamine more ... CTD PMID:15681799|PMID:17964426 App Rat dexamethasone multiple interactions EXP 6480464 [APP protein alternative form co-treated with Dexamethasone] results in decreased expression of ADAM10 mRNA; [APP more ... CTD PMID:22484447 App Rat dextran sulfate multiple interactions ISO RGD:736022 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of APP more ... CTD PMID:29950665 App Rat Di-n-octyl phthalate decreases expression ISO RGD:736022 6480464 di-n-octyl phthalate results in decreased expression of APP mRNA CTD PMID:37810885 App Rat diarsenic trioxide increases expression ISO RGD:736021 6480464 Arsenic Trioxide results in increased expression of APP mRNA CTD PMID:20458559 App Rat dichlorvos increases secretion ISO RGD:736021 6480464 Dichlorvos results in increased secretion of APP protein alternative form CTD PMID:11526466 App Rat dichlorvos increases secretion EXP 6480464 Dichlorvos results in increased secretion of APP protein modified form CTD PMID:7605915|PMID:8624119 App Rat Didymin multiple interactions ISO RGD:736021 6480464 didymin inhibits the reaction [APP protein alternative form results in increased expression of BACE1 protein] CTD PMID:31194956 App Rat dieldrin affects expression EXP 6480464 Dieldrin affects the expression of APP mRNA CTD PMID:22546817 App Rat diethyldithiocarbamic acid multiple interactions ISO RGD:736021 6480464 Ditiocarb inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of APP more ... CTD PMID:28242320 App Rat dihydrogen multiple interactions ISO RGD:736021 6480464 [Hydrogen co-treated with APP protein] results in increased expression of CAT protein; [Hydrogen co-treated with more ... CTD PMID:26271894 App Rat dimercaprol multiple interactions ISO RGD:736021 6480464 [Dimercaprol binds to APP 5' UTR] which results in decreased expression of APP protein; [Dimercaprol more ... CTD PMID:15681799 App Rat dimercaprol affects binding ISO RGD:736021 6480464 Dimercaprol binds to APP 5' UTR CTD PMID:15681799 App Rat dimethylarsinic acid multiple interactions ISO RGD:736021 6480464 Cacodylic Acid results in increased cleavage of and affects the secretion of APP protein mutant more ... CTD PMID:21440049 App Rat dimethylarsinic acid increases expression ISO RGD:736022 6480464 Cacodylic Acid results in increased expression of APP protein CTD PMID:21440049 App Rat diminazene diaceturate affects expression ISO RGD:736022 6480464 diminazene aceturate affects the expression of APP protein alternative form CTD PMID:31982938 App Rat diprotium multiple interactions ISO RGD:736021 6480464 [Hydrogen co-treated with APP protein] results in increased expression of CAT protein; [Hydrogen co-treated with more ... CTD PMID:26271894 App Rat disodium selenite decreases expression ISO RGD:736022 6480464 Sodium Selenite results in decreased expression of APP mRNA CTD PMID:23274088 App Rat disulfiram multiple interactions ISO RGD:736021 6480464 [Disulfiram binds to Copper] which results in increased expression of APP mRNA CTD PMID:24690739 App Rat diuron decreases expression EXP 6480464 Diuron results in decreased expression of APP mRNA CTD PMID:21551480 App Rat dizocilpine maleate multiple interactions EXP 6480464 Dizocilpine Maleate inhibits the reaction [Pentylenetetrazole results in increased expression of APP mRNA] CTD PMID:9720974 App Rat donepezil hydrochloride multiple interactions ISO RGD:736022 6480464 Donepezil inhibits the reaction [APP protein modified form affects the localization of RELA protein]; Donepezil more ... CTD PMID:24189446|PMID:30481507 App Rat donepezil hydrochloride increases abundance ISO RGD:736022 6480464 Donepezil results in increased abundance of APP protein CTD PMID:18061284 App Rat donepezil hydrochloride multiple interactions EXP 6480464 Donepezil inhibits the reaction [[Dietary Fats co-treated with Cholesterol, Dietary] results in increased expression of more ... CTD PMID:24189446|PMID:28734741 App Rat donepezil hydrochloride decreases response to substance EXP 6480464 Donepezil results in decreased susceptibility to APP protein CTD PMID:18571635 App Rat dorsomorphin multiple interactions ISO RGD:736021 6480464 dorsomorphin inhibits the reaction [Hydrogen inhibits the reaction [APP protein results in decreased expression of more ... CTD PMID:20080969|PMID:26271894 App Rat doxorubicin affects response to substance ISO RGD:736021 6480464 APP protein affects the susceptibility to Doxorubicin CTD PMID:17608641 App Rat doxorubicin decreases expression ISO RGD:736021 6480464 Doxorubicin results in decreased expression of APP mRNA CTD PMID:29803840 App Rat doxorubicin multiple interactions ISO RGD:736021 6480464 TP53 protein affects the reaction [APP protein affects the susceptibility to Doxorubicin] CTD PMID:17608641 App Rat DPCPX multiple interactions EXP 6480464 1,3-dipropyl-8-cyclopentylxanthine inhibits the reaction [cordycepin inhibits the reaction [APP protein modified form results in increased more ... CTD PMID:30031108 App Rat duvoglustat decreases response to substance ISO RGD:736022 6480464 1-Deoxynojirimycin results in decreased susceptibility to APP protein CTD PMID:19028522 App Rat edaravone multiple interactions EXP 6480464 Edaravone inhibits the reaction [APP protein modified form results in decreased expression of BCL2 mRNA]; more ... CTD PMID:26111763 App Rat elemental selenium decreases expression ISO RGD:736021 6480464 Selenium results in decreased expression of APP mRNA CTD PMID:19244175 App Rat ellagic acid multiple interactions EXP 6480464 Ellagic Acid inhibits the reaction [Aluminum Chloride results in increased expression of APP protein] CTD PMID:34944019 App Rat enzalutamide affects expression ISO RGD:736021 6480464 enzalutamide affects the expression of APP mRNA CTD PMID:30940724 App Rat ethanol increases expression ISO RGD:736022 6480464 Ethanol results in increased expression of APP mRNA CTD PMID:30319688 App Rat ethanol multiple interactions ISO RGD:736022 6480464 Ethanol affects the expression of and affects the splicing of APP mRNA CTD PMID:30319688 App Rat ethosuximide multiple interactions EXP 6480464 Ethosuximide inhibits the reaction [APP protein modified form results in decreased expression of APC mRNA]; more ... CTD PMID:26420483 App Rat Ethyl maltol multiple interactions ISO RGD:736021 6480464 [APP protein co-treated with ethyl maltol] results in increased expression of CDKN1A mRNA; APP protein more ... CTD PMID:37606557 App Rat ethylenediaminetetraacetic acid multiple interactions ISO RGD:736021 6480464 Edetic Acid inhibits the reaction [[[[APP protein modified form binds to Copper] which co-treated with more ... CTD PMID:17964426 App Rat farrerol multiple interactions EXP 6480464 farrerol inhibits the reaction [APP protein binds to APP protein] CTD PMID:17323972 App Rat fenofibrate multiple interactions ISO RGD:736021 6480464 Fenofibrate affects the reaction [PSEN1 protein affects the cleavage of APP protein] CTD PMID:17962197 App Rat ferroheme b multiple interactions ISO RGD:736021 6480464 [Hydrogen Peroxide co-treated with Sodium Nitrite] promotes the reaction [APP protein modified form binds to more ... CTD PMID:25211009 App Rat ferroheme b affects binding ISO RGD:736021 6480464 APP protein modified form binds to Heme CTD PMID:25211009 App Rat finasteride increases expression EXP 6480464 Finasteride results in increased expression of APP mRNA CTD PMID:24136188 App Rat fipronil increases expression EXP 6480464 fipronil results in increased expression of APP mRNA CTD PMID:23962444 App Rat fisetin multiple interactions ISO RGD:736022 6480464 fisetin inhibits the reaction [Lead results in increased expression of APP protein] CTD PMID:31539617 App Rat flurbiprofen affects cleavage ISO RGD:736022 6480464 Flurbiprofen affects the cleavage of APP protein CTD PMID:14690522 App Rat flurbiprofen decreases secretion ISO RGD:736021 6480464 Flurbiprofen results in decreased secretion of APP protein CTD PMID:17292621|PMID:19659691 App Rat flurbiprofen multiple interactions ISO RGD:736021 6480464 alitretinoin inhibits the reaction [Flurbiprofen results in decreased secretion of APP protein]; Flurbiprofen inhibits the more ... CTD PMID:19659691 App Rat flurbiprofen multiple interactions EXP 6480464 Flurbiprofen inhibits the reaction [APP protein results in increased uptake of Calcium] CTD PMID:18648507 App Rat flutamide decreases expression EXP 6480464 Flutamide results in decreased expression of APP mRNA CTD PMID:24793618 App Rat flutamide multiple interactions EXP 6480464 Flutamide inhibits the reaction [Trenbolone Acetate analog results in increased expression of APP protein modified more ... CTD PMID:25461682 App Rat folic acid multiple interactions ISO RGD:736022 6480464 [1,2-Dimethylhydrazine co-treated with Folic Acid] results in increased expression of APP mRNA; [Methionine deficiency co-treated more ... CTD PMID:20938992|PMID:22206623|PMID:29068127 App Rat folic acid multiple interactions ISO RGD:736021 6480464 APP protein affects the reaction [Folic Acid affects the expression of DNMT1 mRNA]; APP protein more ... CTD PMID:26492244 App Rat folic acid decreases expression ISO RGD:736021 6480464 Folic Acid results in decreased expression of APP protein CTD PMID:26492244 App Rat folpet decreases expression ISO RGD:736022 6480464 folpet results in decreased expression of APP mRNA CTD PMID:31558096 App Rat fonofos increases methylation ISO RGD:736021 6480464 Fonofos results in increased methylation of APP promoter CTD PMID:22847954 App Rat fructose 6-phosphate decreases abundance ISO RGD:736021 6480464 APP protein mutant form results in decreased abundance of fructose-6-phosphate CTD PMID:39172838 App Rat fructose 6-phosphate multiple interactions ISO RGD:736021 6480464 PF-06840003 inhibits the reaction [APP protein mutant form results in decreased abundance of fructose-6-phosphate] CTD PMID:39172838 App Rat fulvestrant multiple interactions EXP 6480464 fulvestrant inhibits the reaction [Trenbolone Acetate analog results in increased expression of APP protein modified more ... CTD PMID:25461682 App Rat fulvestrant multiple interactions ISO RGD:736021 6480464 [bisphenol A co-treated with Fulvestrant] results in decreased methylation of APP gene; [bisphenol F co-treated more ... CTD PMID:31601247 App Rat fumaric acid multiple interactions ISO RGD:736022 6480464 [APP protein mutant form co-treated with PSEN1 protein mutant form] results in decreased abundance of more ... CTD PMID:39172838 App Rat fumonisin B1 increases expression ISO RGD:736022 6480464 fumonisin B1 results in increased expression of APP mRNA CTD PMID:16221962 App Rat furan increases expression EXP 6480464 furan results in increased expression of APP mRNA CTD PMID:25539665 App Rat galactose multiple interactions ISO RGD:736022 6480464 [Galactose co-treated with Aluminum Chloride] results in decreased expression of APP protein; astragalin inhibits the more ... CTD PMID:35537655 App Rat galanthamine multiple interactions ISO RGD:736022 6480464 Galantamine inhibits the reaction [APP protein modified form results in decreased expression of CHRNA7 protein]; more ... CTD PMID:25881725 App Rat galanthamine Trifluoroacetic acid multiple interactions ISO RGD:736022 6480464 Galantamine inhibits the reaction [APP protein modified form results in decreased expression of CHRNA7 protein]; more ... CTD PMID:25881725 App Rat gallic acid multiple interactions ISO RGD:736021 6480464 Gallic Acid inhibits the reaction [2,3-dihydroxybenzoic acid inhibits the reaction [APP protein modified form binds more ... CTD PMID:22129351 App Rat gamma-tocopherol decreases abundance EXP 6480464 APP protein modified form results in decreased abundance of Tocopherols CTD PMID:25654502 App Rat gamma-tocopherol multiple interactions EXP 6480464 resveratrol inhibits the reaction [APP protein modified form results in decreased abundance of Tocopherols] CTD PMID:25654502 App Rat Garcinone C multiple interactions ISO RGD:736021 6480464 garcinone C inhibits the reaction [APP protein binds to APP protein] CTD PMID:38552766 App Rat Garcinone D multiple interactions ISO RGD:736021 6480464 garcinone D inhibits the reaction [APP protein binds to APP protein] CTD PMID:38552766 App Rat genistein increases expression ISO RGD:736022 6480464 Genistein results in increased expression of APP mRNA CTD PMID:32186404 App Rat gentamycin increases expression EXP 6480464 Gentamicins results in increased expression of APP mRNA CTD PMID:22061828 App Rat ginkgolide B multiple interactions ISO RGD:736021 6480464 ginkgolide B inhibits the reaction [APP protein results in increased abundance of Reactive Oxygen Species]; more ... CTD PMID:19464278 App Rat Ginkgolide C multiple interactions ISO RGD:736021 6480464 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [ginkgolide C inhibits the reaction [APP protein results in decreased phosphorylation more ... CTD PMID:18001288 App Rat ginsenoside Rd multiple interactions EXP 6480464 ginsenoside Rd inhibits the reaction [APP protein modified form results in decreased expression of BCL2 more ... CTD PMID:26111763 App Rat ginsenoside Rg1 multiple interactions EXP 6480464 ginsenoside Rg1 inhibits the reaction [[APP protein alternative form co-treated with Dexamethasone] results in decreased more ... CTD PMID:22484447 App Rat ginsenoside Rg2 multiple interactions EXP 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ginsenoside Rg2 inhibits the reaction [APP protein modified form results in more ... CTD PMID:28756148 App Rat glucose multiple interactions ISO RGD:736022 6480464 [APP protein mutant form co-treated with PSEN1 protein mutant form co-treated with PF-06840003] results in more ... CTD PMID:39172838 App Rat glucose multiple interactions ISO RGD:736021 6480464 PF-06840003 inhibits the reaction [APP protein mutant form results in increased abundance of Glucose] CTD PMID:39172838 App Rat glucose increases abundance ISO RGD:736021 6480464 APP protein mutant form results in increased abundance of Glucose CTD PMID:39172838 App Rat glutathione multiple interactions EXP 6480464 resveratrol inhibits the reaction [APP protein modified form results in decreased abundance of Glutathione] CTD PMID:25654502 App Rat glutathione decreases abundance ISO RGD:736022 6480464 APP protein modified form results in decreased abundance of Glutathione CTD PMID:29545167 App Rat glutathione multiple interactions ISO RGD:736022 6480464 vitexin inhibits the reaction [APP protein modified form results in decreased abundance of Glutathione] CTD PMID:29545167 App Rat glutathione decreases abundance EXP 6480464 APP protein modified form results in decreased abundance of Glutathione CTD PMID:25654502 App Rat glyceraldehyde 3-phosphate multiple interactions ISO RGD:736022 6480464 [APP protein mutant form co-treated with PSEN1 protein mutant form] results in decreased abundance of more ... CTD PMID:39172838 App Rat glyceraldehyde 3-phosphate decreases abundance ISO RGD:736021 6480464 APP protein mutant form results in decreased abundance of Glyceraldehyde 3-Phosphate CTD PMID:39172838 App Rat glyceraldehyde 3-phosphate multiple interactions ISO RGD:736021 6480464 PF-06840003 inhibits the reaction [APP protein mutant form results in decreased abundance of Glyceraldehyde 3-Phosphate] CTD PMID:39172838 App Rat glycerol 1-phosphate decreases abundance ISO RGD:736021 6480464 APP protein mutant form results in decreased abundance of alpha-glycerophosphoric acid CTD PMID:39172838 App Rat glycerol 1-phosphate multiple interactions ISO RGD:736021 6480464 PF-06840003 inhibits the reaction [APP protein mutant form results in decreased abundance of alpha-glycerophosphoric acid] CTD PMID:39172838 App Rat glycerol 1-phosphate multiple interactions ISO RGD:736022 6480464 [APP protein mutant form co-treated with PSEN1 protein mutant form] results in decreased abundance of more ... CTD PMID:39172838 App Rat glycine multiple interactions ISO RGD:736022 6480464 [APP protein mutant form co-treated with PSEN1 protein mutant form] results in decreased abundance of more ... CTD PMID:39172838 App Rat glycine betaine multiple interactions ISO RGD:736022 6480464 Betaine inhibits the reaction [Azacitidine results in decreased methylation of APP promoter]; Betaine inhibits the more ... CTD PMID:19635394 App Rat glycitin multiple interactions EXP 6480464 glycitin inhibits the reaction [APP protein binds to APP protein] CTD PMID:17323972 App Rat glyphosate increases expression ISO RGD:736021 6480464 Glyphosate results in increased expression of APP mRNA CTD PMID:31874349 App Rat Goe 6976 multiple interactions ISO RGD:736021 6480464 Go 6976 inhibits the reaction [Phorbol 12,13-Dibutyrate results in increased secretion of APP protein modified more ... CTD PMID:19476501 App Rat GTP increases secretion ISO RGD:736021 6480464 Guanosine Triphosphate results in increased secretion of APP protein modified form CTD PMID:22906069 App Rat GW 501516 multiple interactions ISO RGD:736021 6480464 GW 501516 inhibits the reaction [APP gene mutant form results in decreased expression of GCH1 more ... CTD PMID:22886847 App Rat heme b affects binding ISO RGD:736021 6480464 APP protein modified form binds to Heme CTD PMID:25211009 App Rat heme b multiple interactions ISO RGD:736021 6480464 [Hydrogen Peroxide co-treated with Sodium Nitrite] promotes the reaction [APP protein modified form binds to more ... CTD PMID:25211009 App Rat heparin multiple interactions ISO RGD:736021 6480464 Copper promotes the reaction [Heparin binds to APP protein]; Zinc promotes the reaction [Heparin binds more ... CTD PMID:25835329 App Rat heroin decreases expression ISO RGD:736021 6480464 Heroin results in decreased expression of APP mRNA CTD PMID:16710320 App Rat hexaconazole increases expression ISO RGD:736022 6480464 hexaconazole results in increased expression of APP mRNA CTD PMID:22045034 App Rat hexadecanoic acid multiple interactions ISO RGD:736021 6480464 [Palmitic Acid co-treated with Arsenic] affects the expression of APP mRNA CTD PMID:33736254 App Rat hexadecanoic acid affects expression ISO RGD:736021 6480464 Palmitic Acid affects the expression of APP mRNA CTD PMID:33736254 App Rat homocysteine increases abundance ISO RGD:736022 6480464 APP protein results in increased abundance of Homocysteine CTD PMID:16837103 App Rat hydrogen peroxide multiple interactions ISO RGD:736021 6480464 4-((alpha-L-rhamnosyloxy)benzyl)isothiocyanate inhibits the reaction [Hydrogen Peroxide results in increased expression of APP mRNA]; [APP protein more ... CTD PMID:15699049|PMID:22906069|PMID:23726866|PMID:24276282|PMID:25211009|PMID:31521693 App Rat hydrogen peroxide decreases secretion ISO RGD:736021 6480464 Hydrogen Peroxide results in decreased secretion of APP protein modified form CTD PMID:22906069 App Rat hydrogen peroxide affects expression ISO RGD:736021 6480464 Hydrogen Peroxide affects the expression of APP mRNA; Hydrogen Peroxide affects the expression of APP more ... CTD PMID:21179406 App Rat hydrogen peroxide increases expression ISO RGD:736021 6480464 Hydrogen Peroxide results in increased expression of APP mRNA; Hydrogen Peroxide results in increased expression more ... CTD PMID:12419474|PMID:23726866|PMID:31521693 App Rat hydroquinone multiple interactions ISO RGD:736022 6480464 [KMT2A mutant form results in decreased susceptibility to hydroquinone] which results in increased expression of more ... CTD PMID:37245849 App Rat ibuprofen affects cleavage ISO RGD:736021 6480464 Ibuprofen affects the cleavage of APP protein CTD PMID:11700559|PMID:12777371 App Rat ibuprofen multiple interactions EXP 6480464 Ibuprofen inhibits the reaction [APP protein results in increased uptake of Calcium] CTD PMID:18648507 App Rat ibuprofen multiple interactions ISO RGD:736022 6480464 Ibuprofen inhibits the reaction [[APP protein co-treated with IFNG protein] results in increased abundance of more ... CTD PMID:11080519 App Rat ibuprofen decreases expression ISO RGD:736021 6480464 Ibuprofen results in decreased expression of APP protein mutant form CTD PMID:15817521 App Rat ibuprofen multiple interactions ISO RGD:736021 6480464 Ibuprofen inhibits the reaction [[IFNG protein co-treated with IL1B protein] results in increased metabolism of more ... CTD PMID:14586007 App Rat icariin multiple interactions EXP 6480464 icariin inhibits the reaction [APP protein alternative form results in decreased expression of SOD2 mRNA]; more ... CTD PMID:19782061 App Rat idarubicin increases response to substance ISO RGD:736022 6480464 APP gene mutant form results in increased susceptibility to Idarubicin CTD PMID:25926793 App Rat IMP multiple interactions ISO RGD:736022 6480464 [APP protein mutant form co-treated with PSEN1 protein mutant form] results in decreased abundance of more ... CTD PMID:39172838 App Rat IMP increases abundance ISO RGD:736021 6480464 APP protein mutant form results in increased abundance of Inosine Monophosphate CTD PMID:39172838 App Rat IMP multiple interactions ISO RGD:736021 6480464 PF-06840003 inhibits the reaction [APP protein mutant form results in increased abundance of Inosine Monophosphate] CTD PMID:39172838 App Rat indole-3-methanol affects expression EXP 6480464 indole-3-carbinol affects the expression of APP mRNA CTD PMID:21396975 App Rat indometacin multiple interactions ISO RGD:736021 6480464 Indomethacin inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased metabolism of more ... CTD PMID:14586007|PMID:16111494 App Rat indometacin decreases expression ISO RGD:736022 6480464 Indomethacin results in decreased expression of APP protein alternative form CTD PMID:15579461|PMID:17627676 App Rat indometacin multiple interactions EXP 6480464 Indomethacin inhibits the reaction [APP protein results in increased uptake of Calcium] CTD PMID:18648507 App Rat indometacin multiple interactions ISO RGD:736022 6480464 Indomethacin inhibits the reaction [[APP protein co-treated with IFNG protein] results in increased abundance of more ... CTD PMID:11080519 App Rat indometacin affects cleavage ISO RGD:736021 6480464 Indomethacin affects the cleavage of APP protein CTD PMID:11700559 App Rat inosine multiple interactions ISO RGD:736022 6480464 [APP protein mutant form co-treated with PSEN1 protein mutant form] results in decreased abundance of more ... CTD PMID:39172838 App Rat inulin multiple interactions ISO RGD:736022 6480464 [perfluorooctane sulfonic acid co-treated with Inulin] results in decreased expression of APP mRNA CTD PMID:36331819 App Rat iron atom increases uptake ISO RGD:736021 6480464 Iron results in increased uptake of APP protein CTD PMID:15993987 App Rat iron atom increases expression ISO RGD:736021 6480464 Iron results in increased expression of APP mRNA CTD PMID:16308480 App Rat iron(0) increases expression ISO RGD:736021 6480464 Iron results in increased expression of APP mRNA CTD PMID:16308480 App Rat iron(0) increases uptake ISO RGD:736021 6480464 Iron results in increased uptake of APP protein CTD PMID:15993987 App Rat iron(2+) sulfate (anhydrous) multiple interactions EXP 6480464 (22R, 25R)-20alpha-spirost-5-en-3beta-yl hexanoate inhibits the reaction [[ferrous sulfate co-treated with APP protein alternative form co-treated more ... CTD PMID:19850110 App Rat isoflurane multiple interactions ISO RGD:736021 6480464 APP protein promotes the reaction [Isoflurane results in increased cleavage of and results in increased more ... CTD PMID:17287498 App Rat isoflurane increases expression EXP 597931096 isoflurane increases expression of APP protein in hippocampus RGD App Rat isoniazide increases expression ISO RGD:736021 6480464 Isoniazid results in increased expression of APP mRNA CTD PMID:30008028 App Rat ivermectin decreases expression ISO RGD:736021 6480464 Ivermectin results in decreased expression of APP protein CTD PMID:32959892 App Rat kaempferol multiple interactions EXP 6480464 kaempferol inhibits the reaction [APP protein binds to APP protein] CTD PMID:17323972 App Rat kaempferol 3-O-beta-D-glucoside multiple interactions ISO RGD:736022 6480464 astragalin inhibits the reaction [[Galactose co-treated with Aluminum Chloride] results in decreased expression of APP more ... CTD PMID:35537655 App Rat ketamine multiple interactions ISO RGD:736022 6480464 [Ketamine results in increased cleavage of APP protein] which results in increased abundance of amyloid more ... CTD PMID:35378374 App Rat ketamine multiple interactions ISO RGD:736021 6480464 Ketamine results in decreased expression of and results in increased cleavage of APP protein; Monensin more ... CTD PMID:35378374 App Rat ketamine increases expression ISO RGD:736021 6480464 Ketamine results in increased expression of APP mRNA CTD PMID:35378374 App Rat keto-D-fructose 1,6-bisphosphate decreases abundance ISO RGD:736021 6480464 APP protein mutant form results in decreased abundance of fructose-1,6-diphosphate CTD PMID:39172838 App Rat keto-D-fructose 1,6-bisphosphate multiple interactions ISO RGD:736021 6480464 PF-06840003 inhibits the reaction [APP protein mutant form results in decreased abundance of fructose-1,6-diphosphate] CTD PMID:39172838 App Rat keto-D-fructose 1,6-bisphosphate multiple interactions ISO RGD:736022 6480464 [APP protein mutant form co-treated with PSEN1 protein mutant form] results in decreased abundance of more ... CTD PMID:39172838 App Rat kojic acid increases expression ISO RGD:736021 6480464 kojic acid results in increased expression of APP mRNA CTD PMID:16595896 App Rat KT 5720 multiple interactions ISO RGD:736022 6480464 KT 5720 inhibits the reaction [cilostazol inhibits the reaction [APP protein results in decreased expression more ... CTD PMID:24254769 App Rat KT 5823 multiple interactions ISO RGD:736021 6480464 KT 5823 inhibits the reaction [Ginkgo biloba extract inhibits the reaction [APP protein results in more ... CTD PMID:18001288 App Rat kynurenine multiple interactions ISO RGD:736022 6480464 [APP protein mutant form co-treated with PSEN1 protein mutant form] results in increased abundance of more ... CTD PMID:39172838 App Rat kynurenine multiple interactions ISO RGD:736021 6480464 PF-06840003 inhibits the reaction [APP protein mutant form results in increased abundance of Kynurenine] CTD PMID:39172838 App Rat kynurenine increases abundance ISO RGD:736021 6480464 APP protein mutant form results in increased abundance of Kynurenine CTD PMID:39172838 App Rat L-arginine multiple interactions ISO RGD:736021 6480464 PF-06840003 inhibits the reaction [APP protein mutant form results in decreased abundance of Arginine] CTD PMID:39172838 App Rat L-arginine decreases abundance ISO RGD:736021 6480464 APP protein mutant form results in decreased abundance of Arginine CTD PMID:39172838 App Rat L-arginine multiple interactions ISO RGD:736022 6480464 [APP protein mutant form co-treated with PSEN1 protein mutant form] results in decreased abundance of more ... CTD PMID:39172838 App Rat L-ascorbic acid increases oxidation ISO RGD:736021 6480464 APP protein modified form results in increased oxidation of Ascorbic Acid CTD PMID:17964426 App Rat L-ascorbic acid decreases abundance EXP 6480464 APP protein modified form results in decreased abundance of Ascorbic Acid CTD PMID:25654502 App Rat L-ascorbic acid multiple interactions EXP 6480464 Ascorbic Acid inhibits the reaction [APP protein modified form results in increased abundance of Reactive more ... CTD PMID:15030205|PMID:25654502 App Rat L-ascorbic acid multiple interactions ISO RGD:736021 6480464 [[[APP protein modified form binds to Copper] which co-treated with Ascorbic Acid] results in increased more ... CTD PMID:17964426|PMID:24276282 App Rat L-cysteine decreases abundance ISO RGD:736021 6480464 APP protein mutant form results in decreased abundance of Cysteine CTD PMID:39172838 App Rat L-cysteine multiple interactions ISO RGD:736021 6480464 PF-06840003 inhibits the reaction [APP protein mutant form results in decreased abundance of Cysteine] CTD PMID:39172838 App Rat L-cysteine multiple interactions ISO RGD:736022 6480464 [APP protein mutant form co-treated with PSEN1 protein mutant form] results in decreased abundance of more ... CTD PMID:39172838 App Rat L-erythro-7,8-dihydrobiopterin increases abundance ISO RGD:736021 6480464 APP gene mutant form results in increased abundance of 7,8-dihydrobiopterin CTD PMID:22886847 App Rat L-erythro-7,8-dihydrobiopterin multiple interactions ISO RGD:736021 6480464 GW 501516 inhibits the reaction [APP gene mutant form results in increased abundance of 7,8-dihydrobiopterin] CTD PMID:22886847 App Rat L-glutamic acid multiple interactions ISO RGD:736022 6480464 [APP protein mutant form co-treated with PSEN1 protein mutant form] results in decreased abundance of more ... CTD PMID:39172838 App Rat L-glutamine multiple interactions ISO RGD:736021 6480464 PF-06840003 inhibits the reaction [APP protein mutant form results in decreased abundance of Glutamine] CTD PMID:39172838 App Rat L-glutamine decreases abundance ISO RGD:736021 6480464 APP protein mutant form results in decreased abundance of Glutamine CTD PMID:39172838 App Rat L-histidine multiple interactions ISO RGD:736021 6480464 PF-06840003 inhibits the reaction [APP protein mutant form results in decreased abundance of Histidine] CTD PMID:39172838 App Rat L-histidine decreases abundance ISO RGD:736021 6480464 APP protein mutant form results in decreased abundance of Histidine CTD PMID:39172838 App Rat L-histidine multiple interactions ISO RGD:736022 6480464 [APP protein mutant form co-treated with PSEN1 protein mutant form] results in decreased abundance of more ... CTD PMID:39172838 App Rat L-isoleucine decreases abundance ISO RGD:736021 6480464 APP protein mutant form results in decreased abundance of Isoleucine CTD PMID:39172838 App Rat L-isoleucine multiple interactions ISO RGD:736021 6480464 PF-06840003 inhibits the reaction [APP protein mutant form results in decreased abundance of Isoleucine] CTD PMID:39172838 App Rat L-lysine multiple interactions ISO RGD:736021 6480464 PF-06840003 inhibits the reaction [APP protein mutant form results in decreased abundance of Lysine] CTD PMID:39172838 App Rat L-lysine decreases abundance ISO RGD:736021 6480464 APP protein mutant form results in decreased abundance of Lysine CTD PMID:39172838 App Rat L-methionine multiple interactions ISO RGD:736022 6480464 [APP protein mutant form co-treated with PSEN1 protein mutant form] results in decreased abundance of more ... CTD PMID:20938992|PMID:39172838 App Rat L-serine multiple interactions EXP 6480464 [LAMC1 protein modified form co-treated with ANGPT1 protein co-treated with Serine] inhibits the reaction [beta-N-methylamino-L-alanine more ... CTD PMID:30476904 App Rat L-tryptophan multiple interactions ISO RGD:736021 6480464 PF-06840003 inhibits the reaction [APP protein mutant form results in decreased abundance of Tryptophan] CTD PMID:39172838 App Rat L-tryptophan decreases abundance ISO RGD:736021 6480464 APP protein mutant form results in decreased abundance of Tryptophan CTD PMID:39172838 App Rat lactacystin multiple interactions ISO RGD:736021 6480464 lactacystin inhibits the reaction [resveratrol results in decreased secretion of APP protein] CTD PMID:16162502 App Rat lead diacetate increases expression ISO RGD:736022 6480464 lead acetate results in increased expression of APP mRNA; lead acetate results in increased expression more ... CTD PMID:22279679|PMID:23867794 App Rat lead diacetate affects expression EXP 6480464 lead acetate affects the expression of APP protein CTD PMID:36539177 App Rat lead diacetate multiple interactions ISO RGD:736022 6480464 [lead acetate results in increased abundance of Lead] which results in increased expression of APP more ... CTD PMID:31730887|PMID:32058320 App Rat lead diacetate multiple interactions EXP 6480464 Proanthocyanidins inhibits the reaction [lead acetate results in increased expression of APP protein modified form] CTD PMID:25088297 App Rat lead diacetate increases expression ISO RGD:736021 6480464 lead acetate results in increased expression of APP protein modified form CTD PMID:24462621 App Rat lead diacetate multiple interactions ISO RGD:736021 6480464 [[lead acetate results in increased abundance of Lead] which co-treated with APP protein modified form] more ... CTD PMID:24462621|PMID:31843630 App Rat lead diacetate decreases methylation EXP 6480464 lead acetate results in decreased methylation of APP promoter CTD PMID:21117136|PMID:22764079 App Rat lead diacetate increases expression EXP 6480464 lead acetate results in increased expression of APP mRNA; lead acetate results in increased expression more ... CTD PMID:21117136|PMID:22764079|PMID:24806610|PMID:25088297|PMID:29908845 App Rat lead tetraacetate decreases expression ISO RGD:736022 6480464 lead tetraacetate results in decreased expression of APP mRNA CTD PMID:20865013 App Rat lead(0) affects abundance EXP 6480464 Lead affects the abundance of APP mRNA; Lead affects the abundance of APP protein CTD PMID:16230335 App Rat lead(0) increases expression ISO RGD:736022 6480464 Lead results in increased expression of APP protein CTD PMID:31539617 App Rat lead(0) multiple interactions ISO RGD:736022 6480464 [lead acetate results in increased abundance of Lead] which results in increased expression of APP more ... CTD PMID:31539617|PMID:31730887|PMID:32058320 App Rat lead(0) affects splicing ISO RGD:736021 6480464 Lead affects the splicing of APP mRNA CTD PMID:28903495 App Rat lead(0) affects expression ISO RGD:736021 6480464 Lead affects the expression of APP mRNA CTD PMID:28903495 App Rat lead(0) increases secretion ISO RGD:736021 6480464 Lead results in increased secretion of APP protein alternative form CTD PMID:25673500 App Rat lead(0) increases expression EXP 6480464 Lead results in increased expression of APP protein alternative form CTD PMID:25288670 App Rat lead(0) increases localization EXP 6480464 Lead results in increased localization of APP protein CTD PMID:20488202 App Rat lead(0) multiple interactions ISO RGD:736021 6480464 [[lead acetate results in increased abundance of Lead] which co-treated with APP protein modified form] more ... CTD PMID:22610977|PMID:31843630 App Rat lead(0) increases expression ISO RGD:736021 6480464 Lead results in increased expression of APP mRNA; Lead results in increased expression of APP more ... CTD PMID:19921347|PMID:21315759|PMID:22272629|PMID:25673500 App Rat lead(0) decreases expression ISO RGD:736021 6480464 Lead results in decreased expression of APP protein modified form CTD PMID:22313790 App Rat lead(0) multiple interactions EXP 6480464 [Arsenic co-treated with Cadmium co-treated with Lead] promotes the reaction [BACE1 protein results in increased more ... CTD PMID:16230335|PMID:20488202|PMID:25288670 App Rat linoleic acid multiple interactions ISO RGD:736022 6480464 [APP protein mutant form co-treated with PSEN1 protein mutant form] results in decreased abundance of more ... CTD PMID:39172838 App Rat lipopolysaccharide increases expression ISO RGD:736022 6480464 Lipopolysaccharides results in increased expression of APP mRNA CTD PMID:15919760 App Rat lipopolysaccharide multiple interactions ISO RGD:736021 6480464 [Lipopolysaccharides co-treated with IFNG protein] results in increased expression of APP mRNA; [Lipopolysaccharides co-treated with more ... CTD PMID:28242320|PMID:35877022 App Rat lipopolysaccharide multiple interactions EXP 6480464 APP protein modified form inhibits the reaction [Lipopolysaccharides results in increased activity of CEBPD protein]; more ... CTD PMID:15223066|PMID:18405661 App Rat lithium atom multiple interactions ISO RGD:736022 6480464 Lithium inhibits the reaction [APP protein binds to APP protein] CTD PMID:19621015 App Rat lithium atom multiple interactions EXP 6480464 Lithium inhibits the reaction [APP protein alternative form results in decreased expression of BCL2 protein] CTD PMID:10762662 App Rat lithium chloride multiple interactions ISO RGD:736021 6480464 Lithium Chloride inhibits the reaction [Copper affects the localization of APP protein] CTD PMID:24610780 App Rat lithium hydride multiple interactions ISO RGD:736022 6480464 Lithium inhibits the reaction [APP protein binds to APP protein] CTD PMID:19621015 App Rat lithium hydride multiple interactions EXP 6480464 Lithium inhibits the reaction [APP protein alternative form results in decreased expression of BCL2 protein] CTD PMID:10762662 App Rat lovastatin multiple interactions EXP 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Lovastatin results in increased secretion of APP protein modified form]; TAPI-2 more ... CTD PMID:19741129|PMID:29341888 App Rat lovastatin multiple interactions ISO RGD:736021 6480464 [APP protein co-treated with Lovastatin] results in increased secretion of APP protein; [Lovastatin co-treated with more ... CTD PMID:29341888 App Rat lovastatin increases cleavage ISO RGD:736021 6480464 Lovastatin results in increased cleavage of APP protein CTD PMID:29341888 App Rat lovastatin increases cleavage EXP 6480464 Lovastatin results in increased cleavage of APP protein CTD PMID:29341888 App Rat lovastatin increases secretion EXP 6480464 Lovastatin results in increased secretion of APP protein; Lovastatin results in increased secretion of APP more ... CTD PMID:19741129|PMID:29341888 App Rat LY294002 multiple interactions EXP 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [coenzyme Q10 results in decreased susceptibility to APP protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits more ... CTD PMID:19741129|PMID:22186599|PMID:28756148 App Rat LY294002 multiple interactions ISO RGD:736021 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Clioquinol co-treated with Copper] results in decreased expression of APP protein more ... CTD PMID:16648635|PMID:35024177 App Rat malic acid decreases abundance ISO RGD:736021 6480464 APP protein mutant form results in decreased abundance of malic acid CTD PMID:39172838 App Rat malic acid multiple interactions ISO RGD:736022 6480464 [APP protein mutant form co-treated with PSEN1 protein mutant form] results in decreased abundance of more ... CTD PMID:39172838 App Rat malic acid multiple interactions ISO RGD:736021 6480464 PF-06840003 inhibits the reaction [APP protein mutant form results in decreased abundance of malic acid] CTD PMID:39172838 App Rat malonaldehyde multiple interactions ISO RGD:736022 6480464 vitexin inhibits the reaction [APP protein modified form results in increased abundance of Malondialdehyde] CTD PMID:29545167 App Rat malonaldehyde increases abundance ISO RGD:736022 6480464 APP protein modified form results in increased abundance of Malondialdehyde CTD PMID:29545167 App Rat manganese atom increases expression ISO RGD:736021 6480464 Manganese results in increased expression of APP mRNA CTD PMID:18583042 App Rat manganese(0) increases expression ISO RGD:736021 6480464 Manganese results in increased expression of APP mRNA CTD PMID:18583042 App Rat Mecamylamine multiple interactions ISO RGD:736021 6480464 Mecamylamine inhibits the reaction [Nicotine inhibits the reaction [Copper results in increased expression of APP more ... CTD PMID:16627626 App Rat melatonin multiple interactions ISO RGD:736021 6480464 Melatonin affects the reaction [APP protein binds to APP protein]; Melatonin inhibits the reaction [Mercuric more ... CTD PMID:10617124|PMID:18537544 App Rat melatonin multiple interactions EXP 6480464 Melatonin inhibits the reaction [[Aluminum Chloride results in increased expression of APP protein] which results more ... CTD PMID:33130240|PMID:35526705 App Rat melatonin decreases expression ISO RGD:736022 6480464 Melatonin analog results in decreased expression of APP protein; Melatonin results in decreased expression of more ... CTD PMID:18231852 App Rat meloxicam multiple interactions ISO RGD:736022 6480464 meloxicam inhibits the reaction [Aluminum results in increased expression of APP protein] CTD PMID:16928369 App Rat memantine multiple interactions EXP 6480464 Memantine inhibits the reaction [Streptozocin results in increased expression of APP protein modified form] CTD PMID:21290839 App Rat mepanipyrim multiple interactions ISO RGD:736021 6480464 [APP gene mutant form results in increased expression of APP protein modified form] which results more ... CTD PMID:31939705 App Rat mercury atom multiple interactions ISO RGD:736021 6480464 Estradiol inhibits the reaction [Mercury results in increased secretion of APP protein modified form] CTD PMID:12182891 App Rat mercury atom increases secretion ISO RGD:736021 6480464 Mercury results in increased secretion of APP protein alternative form; Mercury results in increased secretion more ... CTD PMID:12182891|PMID:25673500 App Rat mercury dichloride multiple interactions ISO RGD:736021 6480464 Melatonin inhibits the reaction [Mercuric Chloride results in increased secretion of APP protein modified form] CTD PMID:10617124 App Rat mercury dichloride increases secretion ISO RGD:736021 6480464 Mercuric Chloride results in increased secretion of APP protein modified form CTD PMID:10617124 App Rat mercury(0) multiple interactions ISO RGD:736021 6480464 Estradiol inhibits the reaction [Mercury results in increased secretion of APP protein modified form] CTD PMID:12182891 App Rat mercury(0) increases secretion ISO RGD:736021 6480464 Mercury results in increased secretion of APP protein alternative form; Mercury results in increased secretion more ... CTD PMID:12182891|PMID:25673500 App Rat methamphetamine multiple interactions EXP 6480464 Methamphetamine results in increased expression of and results in increased cleavage of APP protein CTD PMID:30367931 App Rat methamphetamine increases secretion EXP 6480464 Methamphetamine results in increased secretion of APP protein CTD PMID:30367931 App Rat methamphetamine increases expression ISO RGD:736021 6480464 Methamphetamine results in increased expression of APP protein CTD PMID:31270305 App Rat methamphetamine multiple interactions ISO RGD:736021 6480464 Rosiglitazone inhibits the reaction [Methamphetamine results in increased expression of APP protein] CTD PMID:31270305 App Rat methapyrilene increases expression EXP 6480464 Methapyrilene results in increased expression of APP mRNA CTD PMID:22484513 App Rat methidathion increases expression ISO RGD:736022 6480464 methidathion results in increased expression of APP mRNA CTD PMID:34813904 App Rat methotrexate decreases expression ISO RGD:736021 6480464 Methotrexate results in decreased expression of APP mRNA CTD PMID:17400583 App Rat methotrexate increases expression ISO RGD:736021 6480464 Methotrexate results in increased expression of APP mRNA CTD PMID:21678067 App Rat methoxychlor affects methylation EXP 6480464 Methoxychlor affects the methylation of APP gene CTD PMID:35440735 App Rat methyllycaconitine multiple interactions ISO RGD:736022 6480464 methyllycaconitine inhibits the reaction [Galantamine inhibits the reaction [APP protein modified form results in decreased more ... CTD PMID:25881725 App Rat methyllycaconitine multiple interactions ISO RGD:736021 6480464 [APP protein co-treated with methyllycaconitine] results in decreased secretion of APP protein CTD PMID:29341888 App Rat methyllycaconitine decreases secretion EXP 6480464 methyllycaconitine results in decreased secretion of APP protein CTD PMID:29341888 App Rat Methysticin multiple interactions ISO RGD:736022 6480464 methysticin inhibits the reaction [[PSEN1 protein co-treated with APP protein] results in increased secretion of more ... CTD PMID:28448946 App Rat minocycline multiple interactions ISO RGD:736022 6480464 Minocycline inhibits the reaction [APP gene mutant form results in increased phosphorylation of EIF2S1 protein] CTD PMID:17406652 App Rat minocycline multiple interactions EXP 6480464 Minocycline inhibits the reaction [APP protein alternative form results in increased activity of CASP12 protein]; more ... CTD PMID:17406652 App Rat miquelianin decreases expression ISO RGD:736021 6480464 quercetin 3-O-glucuronide results in decreased expression of APP protein CTD PMID:23097297 App Rat miquelianin multiple interactions ISO RGD:736021 6480464 quercetin 3-O-glucuronide inhibits the reaction [APP protein binds to APP protein modified form] CTD PMID:23097297 App Rat mitomycin C increases expression ISO RGD:736021 6480464 Mitomycin results in increased expression of APP mRNA CTD PMID:12760830 App Rat monensin A multiple interactions ISO RGD:736021 6480464 Monensin inhibits the reaction [Ketamine results in decreased expression of and results in increased cleavage more ... CTD PMID:35378374 App Rat monensin A multiple interactions ISO RGD:736022 6480464 Monensin inhibits the reaction [[Ketamine results in increased cleavage of APP protein] which results in more ... CTD PMID:35378374 App Rat morin multiple interactions ISO RGD:736021 6480464 morin affects the reaction [APP protein binds to APP protein] CTD PMID:18537544 App Rat N,N-diethyl-m-toluamide multiple interactions EXP 6480464 [Permethrin co-treated with DEET] results in decreased methylation of APP gene CTD PMID:33148267 App Rat N-acetyl-beta-D-glucosamine multiple interactions ISO RGD:736022 6480464 [APP protein mutant form co-treated with PSEN1 protein mutant form] results in decreased abundance of more ... CTD PMID:39172838 App Rat N-acetyl-D-glucosamine multiple interactions ISO RGD:736022 6480464 [APP protein mutant form co-treated with PSEN1 protein mutant form] results in decreased abundance of more ... CTD PMID:39172838 App Rat N-acetyl-L-cysteine multiple interactions ISO RGD:736021 6480464 Acetylcysteine inhibits the reaction [APP protein affects the localization of RELA protein]; Acetylcysteine inhibits the more ... CTD PMID:12684028|PMID:28004443 App Rat N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal multiple interactions ISO RGD:736022 6480464 benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [APP protein modified form results in decreased expression of and more ... CTD PMID:21520056 App Rat N-methyl-N'-nitro-N-nitrosoguanidine multiple interactions ISO RGD:736022 6480464 [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in decreased expression of APP mRNA; [Methylnitronitrosoguanidine co-treated with more ... CTD PMID:19840844 App Rat N-nitrosodiethylamine increases expression EXP 6480464 Diethylnitrosamine results in increased expression of APP mRNA; Diethylnitrosamine results in increased expression of APP more ... CTD PMID:19542621|PMID:19638242|PMID:20387270 App Rat N-nitrosodiethylamine increases expression ISO RGD:736022 6480464 Diethylnitrosamine results in increased expression of APP mRNA CTD PMID:24535843 App Rat N-nitrosodiethylamine multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of APP mRNA CTD PMID:17602206 App Rat N-nitrosodimethylamine affects expression EXP 6480464 Dimethylnitrosamine affects the expression of APP mRNA CTD PMID:25380136 App Rat neoechinulin A multiple interactions ISO RGD:736022 6480464 neoechinulin A inhibits the reaction [[APP protein binds to APP protein binds to APP protein] more ... CTD PMID:23261590 App Rat nickel atom affects binding ISO RGD:736021 6480464 Nickel binds to APP protein alternative form CTD PMID:15699049 App Rat nicotine decreases expression ISO RGD:736021 6480464 Nicotine results in decreased expression of APP mRNA; Nicotine results in decreased expression of APP more ... CTD PMID:16627626 App Rat nicotine increases metabolic processing ISO RGD:736021 6480464 Nicotine results in increased metabolism of APP protein CTD PMID:29618714 App Rat nicotine multiple interactions ISO RGD:736021 6480464 [Nicotine results in increased metabolism of APP protein] which results in increased secretion of APP more ... CTD PMID:16627626|PMID:29618714 App Rat nicotine multiple interactions EXP 6480464 APP protein modified form inhibits the reaction [Nicotine results in increased secretion of Acetylcholine]; spiro(imidazo-(1,2-a)pyridine-3,2-indan)-2(3H)-one more ... CTD PMID:16474004 App Rat nicotine decreases expression ISO RGD:736022 6480464 Nicotine results in decreased expression of APP protein alternative form CTD PMID:17135361 App Rat nimodipine multiple interactions EXP 6480464 Nimodipine inhibits the reaction [APP protein results in increased uptake of Calcium] CTD PMID:12383957 App Rat nitric oxide multiple interactions ISO RGD:736022 6480464 [APP protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide; Ibuprofen inhibits more ... CTD PMID:11080519 App Rat nitroprusside multiple interactions ISO RGD:736022 6480464 APP protein promotes the reaction [Nitroprusside results in decreased activity of CHAT protein] CTD PMID:16724269 App Rat nitroprusside decreases secretion ISO RGD:736022 6480464 Nitroprusside results in decreased secretion of APP protein alternative form CTD PMID:10691295 App Rat notoginsenoside R1 multiple interactions EXP 6480464 notoginsenoside R1 inhibits the reaction [APP protein modified form results in decreased expression of BCL2 more ... CTD PMID:24975829 App Rat notoginsenoside R1 multiple interactions ISO RGD:736022 6480464 notoginsenoside R1 inhibits the reaction [[APP gene mutant form co-treated with PSEN1 gene mutant form] more ... CTD PMID:25714973 App Rat O-propanoyl-L-carnitine increases abundance ISO RGD:736021 6480464 APP protein mutant form results in increased abundance of propionylcarnitine CTD PMID:39172838 App Rat O-propanoyl-L-carnitine multiple interactions ISO RGD:736022 6480464 [APP protein mutant form co-treated with PSEN1 protein mutant form co-treated with PF-06840003] results in more ... CTD PMID:39172838 App Rat O-propanoyl-L-carnitine multiple interactions ISO RGD:736021 6480464 PF-06840003 inhibits the reaction [APP protein mutant form results in increased abundance of propionylcarnitine] CTD PMID:39172838 App Rat ochratoxin A increases expression ISO RGD:736021 6480464 ochratoxin A results in increased expression of APP mRNA CTD PMID:30008028 App Rat okadaic acid multiple interactions ISO RGD:736022 6480464 [Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in decreased expression of APP mRNA CTD PMID:19840844 App Rat olanzapine multiple interactions EXP 6480464 olanzapine inhibits the reaction [APP protein modified form affects the activity of CAT protein]; olanzapine more ... CTD PMID:15948179 App Rat oleic acid multiple interactions ISO RGD:736022 6480464 [APP protein mutant form co-treated with PSEN1 protein mutant form] results in decreased abundance of more ... CTD PMID:39172838 App Rat orlistat multiple interactions ISO RGD:736021 6480464 [1,1,1,2,2-pentafluoro-7-phenylheptan-3-one co-treated with Orlistat] inhibits the reaction [APP protein modified form results in increased secretion more ... CTD PMID:28721267 App Rat ornithine multiple interactions ISO RGD:736022 6480464 [APP protein mutant form co-treated with PSEN1 protein mutant form] results in decreased abundance of more ... CTD PMID:39172838 App Rat orphenadrine affects expression EXP 6480464 Orphenadrine affects the expression of APP mRNA CTD PMID:23665939 App Rat oxaloacetic acid multiple interactions ISO RGD:736021 6480464 PF-06840003 inhibits the reaction [APP protein mutant form results in decreased abundance of Oxaloacetic Acid] CTD PMID:39172838 App Rat oxaloacetic acid decreases abundance ISO RGD:736021 6480464 APP protein mutant form results in decreased abundance of Oxaloacetic Acid CTD PMID:39172838 App Rat ozone multiple interactions ISO RGD:736021 6480464 [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased expression of more ... CTD PMID:32699268|PMID:32845096 App Rat ozone multiple interactions ISO RGD:736022 6480464 [Air Pollutants results in increased abundance of Ozone] which results in decreased expression of APP more ... CTD PMID:27106289|PMID:34911549 App Rat ozone increases expression ISO RGD:736022 6480464 Ozone results in increased expression of APP protein CTD PMID:29385576 App Rat ozone increases response to substance ISO RGD:736022 6480464 APP results in increased susceptibility to Ozone CTD PMID:26116027 App Rat p-anisidine affects localization ISO RGD:736022 6480464 4-anisidine affects the localization of APP protein CTD PMID:18949129 App Rat p-anisidine multiple interactions ISO RGD:736022 6480464 4-anisidine affects the reaction [APP protein affects the abundance of Calcium] CTD PMID:18949129 App Rat p-menthan-3-ol decreases expression ISO RGD:736021 6480464 Menthol results in decreased expression of APP mRNA CTD PMID:26760959 App Rat palmitoleic acid multiple interactions ISO RGD:736022 6480464 [APP protein mutant form co-treated with PSEN1 protein mutant form] results in decreased abundance of more ... CTD PMID:39172838 App Rat paracetamol increases expression ISO RGD:736021 6480464 Acetaminophen results in increased expression of APP mRNA CTD PMID:30008028 App Rat paraquat increases response to substance ISO RGD:736021 6480464 APP protein results in increased susceptibility to Paraquat CTD PMID:23827522 App Rat paraquat increases expression EXP 6480464 Paraquat results in increased expression of APP protein; Paraquat results in increased expression of APP more ... CTD PMID:31715309|PMID:32738378 App Rat paraquat increases expression ISO RGD:736021 6480464 Paraquat results in increased expression of APP mRNA; Paraquat results in increased expression of APP more ... CTD PMID:27793699 App Rat paraquat multiple interactions EXP 6480464 [BDNF protein co-treated with MF63 compound co-treated with Estradiol] inhibits the reaction [Paraquat results in more ... CTD PMID:31715309|PMID:32738378 App Rat paraquat multiple interactions ISO RGD:736021 6480464 Carnitine promotes the reaction [Paraquat deficiency inhibits the reaction [Paraquat promotes the reaction [APP protein more ... CTD PMID:27793699|PMID:33290254 App Rat parathion increases methylation ISO RGD:736021 6480464 Parathion results in increased methylation of APP promoter CTD PMID:22847954 App Rat paroxetine multiple interactions ISO RGD:736021 6480464 [Paroxetine binds to APP 5' UTR] which results in decreased secretion of APP protein modified more ... CTD PMID:15681799 App Rat PCB138 multiple interactions ISO RGD:736022 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:26480858 App Rat pentetrazol multiple interactions EXP 6480464 Dizocilpine Maleate inhibits the reaction [Pentylenetetrazole results in increased expression of APP mRNA]; Pentobarbital inhibits more ... CTD PMID:32653415|PMID:9720974 App Rat pentetrazol increases expression EXP 6480464 Pentylenetetrazole results in increased expression of APP mRNA; Pentylenetetrazole results in increased expression of APP more ... CTD PMID:32653415|PMID:9720974 App Rat pentobarbital affects expression EXP 6480464 Pentobarbital affects the expression of APP mRNA CTD PMID:1306490 App Rat pentobarbital multiple interactions EXP 6480464 Pentobarbital inhibits the reaction [Pentylenetetrazole results in increased expression of APP mRNA] CTD PMID:9720974 App Rat perfluorobutanesulfonic acid increases expression ISO RGD:736021 6480464 perfluorobutanesulfonic acid results in increased expression of APP mRNA CTD PMID:33772556 App Rat perfluorooctane-1-sulfonic acid increases expression EXP 6480464 perfluorooctane sulfonic acid results in increased expression of APP protein CTD PMID:27018931 App Rat perfluorooctane-1-sulfonic acid multiple interactions ISO RGD:736022 6480464 [perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of APP mRNA; [perfluorooctane sulfonic more ... CTD PMID:36331819 App Rat perfluorooctane-1-sulfonic acid increases expression ISO RGD:736021 6480464 perfluorooctane sulfonic acid results in increased expression of APP mRNA CTD PMID:33772556 App Rat perfluorooctanoic acid increases expression EXP 6480464 perfluorooctanoic acid results in increased expression of APP mRNA CTD PMID:19162173 App Rat perfluorooctanoic acid increases expression ISO RGD:736021 6480464 perfluorooctanoic acid results in increased expression of APP mRNA CTD PMID:33772556 App Rat perfluorooctanoic acid decreases expression ISO RGD:736021 6480464 perfluorooctanoic acid results in decreased expression of APP protein CTD PMID:26879310 App Rat permethrin multiple interactions EXP 6480464 [Permethrin co-treated with DEET] results in decreased methylation of APP gene CTD PMID:33148267 App Rat Pf-06840003 multiple interactions ISO RGD:736022 6480464 [APP protein mutant form co-treated with PSEN1 protein mutant form co-treated with PF-06840003] results in more ... CTD PMID:39172838 App Rat Pf-06840003 multiple interactions ISO RGD:736021 6480464 PF-06840003 affects the reaction [APP protein mutant form affects the expression of BACE1 protein]; PF-06840003 more ... CTD PMID:39172838 App Rat phenobarbital increases expression EXP 6480464 Phenobarbital results in increased expression of APP mRNA CTD PMID:15093671|PMID:19162173|PMID:28520973 App Rat PhIP increases expression ISO RGD:736022 6480464 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of APP protein; 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of APP more ... CTD PMID:32169473 App Rat phlorizin decreases expression ISO RGD:736022 6480464 Phlorhizin results in decreased expression of APP mRNA CTD PMID:22538082 App Rat phorbol 12,13-dibutanoate increases secretion ISO RGD:736021 6480464 Phorbol 12,13-Dibutyrate results in increased secretion of APP protein modified form CTD PMID:19476501 App Rat phorbol 12,13-dibutanoate multiple interactions ISO RGD:736021 6480464 Go 6976 inhibits the reaction [Phorbol 12,13-Dibutyrate results in increased secretion of APP protein modified more ... CTD PMID:19476501 App Rat phorbol 13-acetate 12-myristate multiple interactions ISO RGD:736022 6480464 [Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of APP mRNA CTD PMID:19840844 App Rat phosphatidylcholine multiple interactions ISO RGD:736021 6480464 [[[APP protein modified form binds to Copper] which co-treated with Ascorbic Acid] results in increased more ... CTD PMID:17964426 App Rat phosphoenolpyruvate multiple interactions ISO RGD:736021 6480464 Phosphoenolpyruvate inhibits the reaction [Rotenone results in decreased secretion of APP protein modified form] CTD PMID:22906069 App Rat phosphoenolpyruvate increases secretion ISO RGD:736021 6480464 Phosphoenolpyruvate results in increased secretion of APP protein modified form CTD PMID:22906069 App Rat physostigmine increases secretion EXP 6480464 Physostigmine results in increased secretion of APP protein modified form CTD PMID:7605915|PMID:8624119 App Rat pifithrin-alpha hydrobromide multiple interactions EXP 6480464 pifithrin inhibits the reaction [APP protein alternative form results in increased expression of BBC3 protein]; more ... CTD PMID:24567336 App Rat pioglitazone decreases expression ISO RGD:736021 6480464 pioglitazone results in decreased expression of APP protein mutant form CTD PMID:15817521 App Rat pioglitazone decreases expression ISO RGD:736022 6480464 pioglitazone results in decreased expression of APP protein CTD PMID:16407166 App Rat pioglitazone multiple interactions ISO RGD:736021 6480464 pioglitazone inhibits the reaction [[IFNG protein co-treated with IL1B protein] results in increased metabolism of more ... CTD PMID:14586007 App Rat piperidine multiple interactions ISO RGD:736021 6480464 piperidine analog inhibits the reaction [ACHE protein promotes the reaction [APP protein binds to APP more ... CTD PMID:17681794 App Rat piperonyl butoxide increases expression EXP 6480464 Piperonyl Butoxide results in increased expression of APP mRNA CTD PMID:22484513 App Rat pirinixic acid decreases expression ISO RGD:736022 6480464 pirinixic acid results in decreased expression of APP mRNA CTD PMID:17426115 App Rat pirinixic acid multiple interactions EXP 6480464 pirinixic acid inhibits the reaction [APP protein results in decreased activity of CAT protein]; pirinixic more ... CTD PMID:16204253 App Rat pirinixic acid affects activity EXP 6480464 pirinixic acid affects the activity of APP protein CTD PMID:16204253 App Rat poly(I:C) multiple interactions EXP 6480464 [Poly I-C co-treated with HU 211] results in decreased expression of APP mRNA CTD PMID:26923065 App Rat poly(vinylpyrrolidone) multiple interactions ISO RGD:736022 6480464 [Silver Compounds co-treated with Povidone] results in increased expression of APP protein CTD PMID:35697184 App Rat potassium atom multiple interactions EXP 6480464 [Zinc promotes the reaction [APP protein binds to APP protein]] which affects the transport of more ... CTD PMID:16674922 App Rat potassium bromate increases expression ISO RGD:736021 6480464 potassium bromate results in increased expression of APP mRNA CTD PMID:30008028 App Rat pravastatin increases expression ISO RGD:736021 6480464 Pravastatin results in increased expression of APP CTD PMID:19461118 App Rat pregabalin multiple interactions ISO RGD:736022 6480464 [APP protein mutant form co-treated with PSEN1 protein mutant form] results in decreased abundance of more ... CTD PMID:39172838 App Rat pregnenolone decreases response to substance EXP 6480464 Pregnenolone results in decreased susceptibility to APP protein modified form CTD PMID:18926803 App Rat pregnenolone 16alpha-carbonitrile increases expression EXP 6480464 Pregnenolone Carbonitrile results in increased expression of APP mRNA CTD PMID:19162173 App Rat proanthocyanidin multiple interactions EXP 6480464 Proanthocyanidins inhibits the reaction [lead acetate results in increased expression of APP protein modified form] CTD PMID:25088297 App Rat probucol multiple interactions EXP 6480464 Probucol inhibits the reaction [[Dietary Fats co-treated with Cholesterol, Dietary] results in increased expression of more ... CTD PMID:26111763|PMID:28734741 App Rat progesterone decreases metabolic processing ISO RGD:736022 6480464 APP gene mutant form results in decreased metabolism of Progesterone metabolite CTD PMID:17988898 App Rat progesterone multiple interactions ISO RGD:736022 6480464 Progesterone inhibits the reaction [APP gene mutant form results in decreased metabolism of Progesterone metabolite] CTD PMID:17988898 App Rat propiconazole increases expression EXP 6480464 propiconazole results in increased expression of APP mRNA CTD PMID:19423681 App Rat prostaglandin D2 increases secretion ISO RGD:736021 6480464 APP protein modified form results in increased secretion of Prostaglandin D2 CTD PMID:28721267 App Rat prostaglandin D2 multiple interactions ISO RGD:736021 6480464 CNB 001 inhibits the reaction [APP protein modified form results in increased secretion of Prostaglandin more ... CTD PMID:28721267 App Rat prostaglandin E2 increases abundance EXP 6480464 APP protein modified form results in increased abundance of Dinoprostone CTD PMID:20171164 App Rat prostaglandin E2 multiple interactions ISO RGD:736021 6480464 CNB 001 inhibits the reaction [APP protein modified form results in increased secretion of Dinoprostone]; more ... CTD PMID:28721267 App Rat prostaglandin E2 increases secretion ISO RGD:736021 6480464 APP protein modified form results in increased secretion of Dinoprostone CTD PMID:28721267 App Rat prostaglandin E2 multiple interactions ISO RGD:736022 6480464 [APP protein binds to APP protein binds to APP protein] which results in increased abundance more ... CTD PMID:23261590 App Rat prostaglandin E2 multiple interactions EXP 6480464 PTGES2 promotes the reaction [APP protein modified form results in increased abundance of Dinoprostone]; resveratrol more ... CTD PMID:16685418|PMID:20171164 App Rat prostaglandin E2 increases expression EXP 6480464 Dinoprostone results in increased expression of APP protein modified form CTD PMID:20171164 App Rat prucalopride increases abundance ISO RGD:736022 6480464 prucalopride results in increased abundance of APP protein CTD PMID:18061284 App Rat pyrimethanil affects binding ISO RGD:736021 6480464 pyrimethanil binds to APP protein modified form CTD PMID:31939705 App Rat pyrimethanil multiple interactions ISO RGD:736021 6480464 [APP gene mutant form results in increased expression of APP protein modified form] which results more ... CTD PMID:31939705 App Rat pyrogallol multiple interactions ISO RGD:736021 6480464 [Copper binds to APP protein alternative form] which results in increased oxidation of Pyrogallol; Hydrogen more ... CTD PMID:15699049 App Rat pyrrolidine dithiocarbamate multiple interactions ISO RGD:736022 6480464 pyrrolidine dithiocarbamic acid results in decreased susceptibility to [APP protein modified form binds to APP more ... CTD PMID:17409235 App Rat quercetin multiple interactions ISO RGD:736021 6480464 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Quercetin inhibits the reaction [APP protein results in decreased phosphorylation of more ... CTD PMID:18001288|PMID:19464278|PMID:22115781 App Rat quetiapine fumarate multiple interactions EXP 6480464 Quetiapine Fumarate inhibits the reaction [APP protein modified form affects the activity of CAT protein]; more ... CTD PMID:15948179 App Rat quinine multiple interactions ISO RGD:736021 6480464 Quinine affects the reaction [APP protein binds to APP protein] CTD PMID:18537544 App Rat rac-lactic acid decreases abundance ISO RGD:736021 6480464 APP protein mutant form results in decreased abundance of Lactic Acid CTD PMID:39172838 App Rat rac-lactic acid multiple interactions ISO RGD:736021 6480464 PF-06840003 inhibits the reaction [APP protein mutant form results in decreased abundance of Lactic Acid] CTD PMID:39172838 App Rat raloxifene affects binding ISO RGD:736021 6480464 Raloxifene Hydrochloride binds to APP protein CTD PMID:31583774 App Rat raloxifene multiple interactions ISO RGD:736021 6480464 Raloxifene Hydrochloride inhibits the reaction [APP protein results in increased expression of TGFB1 mRNA]; Raloxifene more ... CTD PMID:31583774 App Rat reactive nitrogen species multiple interactions ISO RGD:736022 6480464 vitexin inhibits the reaction [APP protein modified form results in increased abundance of Reactive Nitrogen more ... CTD PMID:29545167 App Rat reactive nitrogen species increases abundance ISO RGD:736022 6480464 APP protein modified form results in increased abundance of Reactive Nitrogen Species CTD PMID:29545167 App Rat reactive oxygen species increases abundance EXP 6480464 APP protein modified form results in increased abundance of Reactive Oxygen Species CTD PMID:15030205|PMID:15948179|PMID:29128369 App Rat reactive oxygen species multiple interactions ISO RGD:736022 6480464 5,7-dimethoxycoumarin inhibits the reaction [[TNFSF11 protein co-treated with APP protein] results in increased abundance of more ... CTD PMID:29545167|PMID:37260315 App Rat reactive oxygen species increases abundance ISO RGD:736022 6480464 APP protein modified form results in increased abundance of Reactive Oxygen Species CTD PMID:29545167 App Rat reactive oxygen species multiple interactions ISO RGD:736021 6480464 [Copper co-treated with APP protein modified form] results in increased abundance of Reactive Oxygen Species; more ... CTD PMID:19464278|PMID:21706413 App Rat reactive oxygen species increases abundance ISO RGD:736021 6480464 APP protein results in increased abundance of Reactive Oxygen Species CTD PMID:19464278 App Rat reactive oxygen species multiple interactions EXP 6480464 Ascorbic Acid inhibits the reaction [APP protein modified form results in increased abundance of Reactive more ... CTD PMID:15030205|PMID:15948179|PMID:29128369 App Rat resveratrol affects folding ISO RGD:736021 6480464 resveratrol affects the folding of APP protein modified form CTD PMID:23386614 App Rat resveratrol decreases response to substance EXP 6480464 resveratrol results in decreased susceptibility to APP protein CTD PMID:15134381 App Rat resveratrol multiple interactions EXP 6480464 resveratrol inhibits the reaction [APP protein modified form results in decreased abundance of Ascorbic Acid]; more ... CTD PMID:15134381|PMID:16183991|PMID:16685418|PMID:25654502 App Rat resveratrol decreases secretion ISO RGD:736022 6480464 resveratrol results in decreased secretion of APP protein mutant form CTD PMID:16162502 App Rat resveratrol increases degradation ISO RGD:736021 6480464 resveratrol results in increased degradation of APP protein modified form CTD PMID:20080969 App Rat resveratrol decreases expression ISO RGD:736021 6480464 resveratrol results in decreased expression of APP protein modified form CTD PMID:20080969 App Rat resveratrol affects binding ISO RGD:736021 6480464 resveratrol binds to [APP protein binds to APP protein] CTD PMID:17597573 App Rat resveratrol multiple interactions ISO RGD:736021 6480464 [Plant Extracts co-treated with Resveratrol] results in increased expression of APP mRNA; [Resveratrol results in more ... CTD PMID:16162502|PMID:16212921|PMID:20080969|PMID:23557933 App Rat resveratrol decreases expression ISO RGD:736022 6480464 resveratrol results in decreased expression of APP protein; resveratrol results in decreased expression of APP more ... CTD PMID:20080969|PMID:22118570|PMID:23129026 App Rat resveratrol multiple interactions ISO RGD:736022 6480464 resveratrol inhibits the reaction [APP protein results in decreased expression of and results in decreased more ... CTD PMID:22118570|PMID:24254769 App Rat rimonabant multiple interactions ISO RGD:736022 6480464 Rimonabant inhibits the reaction [Dietary Fats results in increased expression of APP mRNA] CTD PMID:19030233 App Rat rimonabant affects expression ISO RGD:736022 6480464 Rimonabant affects the expression of APP mRNA CTD PMID:19030233 App Rat rotenone decreases secretion ISO RGD:736021 6480464 Rotenone results in decreased secretion of APP protein modified form CTD PMID:22906069 App Rat rotenone multiple interactions ISO RGD:736021 6480464 Adenosine Triphosphate inhibits the reaction [Rotenone results in decreased secretion of APP protein modified form]; more ... CTD PMID:22906069 App Rat rottlerin multiple interactions EXP 6480464 rottlerin inhibits the reaction [PRKCD protein promotes the reaction [Lead results in increased localization of more ... CTD PMID:20488202 App Rat ruthenium red multiple interactions EXP 6480464 Ruthenium Red inhibits the reaction [APP protein modified form results in increased uptake of Calcium] CTD PMID:24457011 App Rat S-adenosyl-L-homocysteine increases expression ISO RGD:736022 6480464 S-Adenosylhomocysteine results in increased expression of APP protein CTD PMID:22064374 App Rat S-adenosyl-L-homocysteine decreases methylation ISO RGD:736022 6480464 S-Adenosylhomocysteine results in decreased methylation of APP promoter CTD PMID:19635394 App Rat S-adenosyl-L-homocysteine multiple interactions ISO RGD:736022 6480464 Betaine inhibits the reaction [S-Adenosylhomocysteine results in decreased methylation of APP promoter]; Betaine inhibits the more ... CTD PMID:19635394 App Rat S-adenosyl-L-methioninate increases secretion ISO RGD:736021 6480464 S-Adenosylmethionine results in increased secretion of APP protein modified form CTD PMID:22906069 App Rat S-adenosyl-L-methionine increases secretion ISO RGD:736021 6480464 S-Adenosylmethionine results in increased secretion of APP protein modified form CTD PMID:22906069 App Rat S-butyl-DL-homocysteine (S,R)-sulfoximine multiple interactions EXP 6480464 (22R, 25R)-20alpha-spirost-5-en-3beta-yl hexanoate inhibits the reaction [[ferrous sulfate co-treated with APP protein alternative form co-treated more ... CTD PMID:19850110 App Rat salicylates multiple interactions EXP 6480464 Salicylates inhibits the reaction [APP protein results in increased uptake of Calcium] CTD PMID:18648507 App Rat sapropterin multiple interactions ISO RGD:736021 6480464 APP gene mutant form results in increased oxidation of and results in decreased abundance of more ... CTD PMID:22886847 App Rat sarin decreases expression ISO RGD:736021 6480464 Sarin results in decreased expression of APP mRNA CTD PMID:19522546 App Rat SB 203580 multiple interactions ISO RGD:736021 6480464 SB 203580 inhibits the reaction [APP protein results in increased expression of and results in more ... CTD PMID:18583042|PMID:28004443 App Rat SB 415286 multiple interactions ISO RGD:736021 6480464 3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Copper affects the localization of APP protein] CTD PMID:24610780 App Rat SB 431542 multiple interactions ISO RGD:736021 6480464 [LDN 193189 co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with FGF2 protein] results in decreased expression of APP more ... CTD PMID:37664457 App Rat SCH772984 multiple interactions EXP 6480464 SCH772984 inhibits the reaction [APP protein modified form results in increased expression of GRK2 protein] CTD PMID:30399361 App Rat scopolamine decreases cleavage ISO RGD:736022 6480464 Scopolamine results in decreased cleavage of APP protein CTD PMID:16423497 App Rat scutellarin multiple interactions EXP 6480464 scutellarin inhibits the reaction [APP protein binds to APP protein] CTD PMID:17323972 App Rat selenium atom decreases expression ISO RGD:736021 6480464 Selenium results in decreased expression of APP mRNA CTD PMID:19244175 App Rat selenomethionine multiple interactions EXP 6480464 Selenomethionine inhibits the reaction [APP protein results in decreased expression of and results in decreased more ... CTD PMID:17280487 App Rat serotonin increases response to substance ISO RGD:736021 6480464 APP protein modified form results in increased susceptibility to Serotonin CTD PMID:28915354|PMID:34902447 App Rat serotonin multiple interactions ISO RGD:736021 6480464 Oils, Volatile inhibits the reaction [[APP protein modified form binds to APP protein modified form] more ... CTD PMID:28915354|PMID:34902447 App Rat sevoflurane multiple interactions ISO RGD:736021 6480464 APP protein modified form promotes the reaction [sevoflurane results in increased cleavage of CASP3 protein]; more ... CTD PMID:19433662 App Rat sevoflurane increases expression EXP 6480464 Sevoflurane results in increased expression of APP protein CTD PMID:35174938 App Rat sevoflurane multiple interactions EXP 6480464 Dietary Fats promotes the reaction [Sevoflurane results in increased expression of APP protein] CTD PMID:35174938 App Rat sevoflurane increases expression ISO RGD:736021 6480464 sevoflurane results in increased expression of APP protein modified form CTD PMID:19433662 App Rat sevoflurane affects cleavage ISO RGD:736021 6480464 sevoflurane affects the cleavage of APP protein CTD PMID:19433662 App Rat sevoflurane increases expression ISO RGD:736022 6480464 sevoflurane results in increased expression of APP protein modified form CTD PMID:19433662 App Rat sevoflurane multiple interactions ISO RGD:736022 6480464 sevoflurane promotes the reaction [CASP3 protein results in increased cleavage of APP protein] CTD PMID:19433662 App Rat silicon dioxide affects secretion ISO RGD:736021 6480464 Silicon Dioxide analog affects the secretion of APP protein CTD PMID:25895662 App Rat silicon dioxide increases expression ISO RGD:736021 6480464 Silicon Dioxide analog results in increased expression of APP protein CTD PMID:24831964 App Rat silicon dioxide increases expression ISO RGD:736022 6480464 Silicon Dioxide analog results in increased expression of APP protein CTD PMID:24831964 App Rat silver atom increases expression ISO RGD:736022 6480464 Silver results in increased expression of APP mRNA; Silver results in increased expression of APP more ... CTD PMID:27131904 App Rat silver(0) increases expression ISO RGD:736022 6480464 Silver results in increased expression of APP mRNA; Silver results in increased expression of APP more ... CTD PMID:27131904 App Rat simvastatin multiple interactions ISO RGD:736021 6480464 oblimersen inhibits the reaction [Simvastatin results in decreased activity of APP protein alternative form]; Simvastatin more ... CTD PMID:17241114 App Rat simvastatin multiple interactions EXP 6480464 Simvastatin inhibits the reaction [[Dietary Fats co-treated with Cholesterol, Dietary] results in increased expression of more ... CTD PMID:28734741 App Rat simvastatin decreases activity ISO RGD:736021 6480464 Simvastatin results in decreased activity of APP protein alternative form CTD PMID:17241114 App Rat sirolimus decreases expression ISO RGD:736021 6480464 Sirolimus results in decreased expression of APP protein modified form CTD PMID:20542014 App Rat sirolimus increases expression ISO RGD:736021 6480464 Sirolimus results in increased expression of APP protein modified form CTD PMID:20542014 App Rat sirolimus increases expression ISO RGD:736022 6480464 Sirolimus results in increased expression of APP protein modified form CTD PMID:20542014 App Rat sirolimus decreases expression ISO RGD:736022 6480464 Sirolimus results in decreased expression of APP protein modified form CTD PMID:20542014 App Rat sirtinol multiple interactions ISO RGD:736022 6480464 sirtinol inhibits the reaction [cilostazol inhibits the reaction [APP protein results in decreased expression of more ... CTD PMID:24254769 App Rat sodium arsenite increases expression ISO RGD:736021 6480464 sodium arsenite results in increased expression of APP mRNA CTD PMID:12760830|PMID:38568856 App Rat sodium arsenite increases expression ISO RGD:736022 6480464 sodium arsenite results in increased expression of APP mRNA; sodium arsenite results in increased expression more ... CTD PMID:21440049|PMID:36209798 App Rat sodium arsenite multiple interactions ISO RGD:736021 6480464 sodium arsenite results in increased cleavage of and affects the secretion of APP protein mutant more ... CTD PMID:21440049 App Rat sodium azide multiple interactions ISO RGD:736021 6480464 [Sodium Azide co-treated with Deoxyglucose] affects the cleavage of and affects the localization of APP more ... CTD PMID:17405930|PMID:22906069 App Rat sodium azide increases expression EXP 6480464 Sodium Azide results in increased expression of APP protein CTD PMID:36249784 App Rat sodium azide multiple interactions EXP 6480464 bergenin affects the reaction [Sodium Azide results in increased expression of APP protein]; bisphenol A more ... CTD PMID:36249784 App Rat sodium dichromate affects expression EXP 6480464 sodium bichromate affects the expression of APP mRNA CTD PMID:22110744 App Rat sodium nitrite multiple interactions ISO RGD:736021 6480464 [Hydrogen Peroxide co-treated with Sodium Nitrite] promotes the reaction [APP protein modified form binds to more ... CTD PMID:25211009 App Rat staurosporine multiple interactions ISO RGD:736021 6480464 Staurosporine inhibits the reaction [Ginkgo biloba extract inhibits the reaction [APP protein results in decreased more ... CTD PMID:12556443|PMID:18001288 App Rat streptozocin multiple interactions EXP 6480464 Memantine inhibits the reaction [Streptozocin results in increased expression of APP protein modified form] CTD PMID:21290839 App Rat streptozocin multiple interactions ISO RGD:736022 6480464 5-Methoxypsoralen inhibits the reaction [Streptozocin results in increased expression of APP protein modified form]; Alendronate more ... CTD PMID:30481507|PMID:34428446 App Rat streptozocin increases expression ISO RGD:736022 6480464 Streptozocin results in increased expression of APP mRNA; Streptozocin results in increased expression of APP more ... CTD PMID:21069392|PMID:30481507|PMID:34428446 App Rat streptozocin increases expression EXP 6480464 Streptozocin results in increased expression of APP protein modified form CTD PMID:21290839 App Rat succinic acid multiple interactions ISO RGD:736022 6480464 IDO1 protein affects the reaction [[APP protein mutant form co-treated with PSEN1 protein mutant form] more ... CTD PMID:39172838 App Rat succinic acid decreases abundance ISO RGD:736021 6480464 APP protein mutant form results in decreased abundance of Succinic Acid CTD PMID:39172838 App Rat succinic acid multiple interactions ISO RGD:736021 6480464 PF-06840003 inhibits the reaction [APP protein mutant form results in decreased abundance of Succinic Acid] CTD PMID:39172838 App Rat sulfur dioxide multiple interactions EXP 6480464 Sulfur Dioxide promotes the reaction [Particulate Matter results in increased cleavage of and results in more ... CTD PMID:28565962 App Rat sulindac multiple interactions ISO RGD:736021 6480464 Sulindac inhibits the reaction [CDKN1A protein results in increased expression of APP mRNA] CTD PMID:15190207 App Rat sulindac sulfide multiple interactions ISO RGD:736021 6480464 [sulindac sulfide results in decreased activity of PSEN1 protein] which affects the cleavage of APP more ... CTD PMID:12805356|PMID:17573346|PMID:17962197|PMID:18359496 App Rat sulindac sulfide multiple interactions EXP 6480464 sulindac sulfide inhibits the reaction [APP protein results in increased uptake of Calcium] CTD PMID:18648507 App Rat sulindac sulfide affects cleavage ISO RGD:736022 6480464 sulindac sulfide affects the cleavage of APP protein CTD PMID:14690522 App Rat sulindac sulfide affects cleavage ISO RGD:736021 6480464 sulindac sulfide affects the cleavage of APP protein CTD PMID:11700559|PMID:12637581|PMID:12777371|PMID:12805356|PMID:15274632|PMID:18426795 App Rat superoxide multiple interactions ISO RGD:736021 6480464 3-benzyl-7-(2-benzoxazolyl)thio-1,2,3-triazolo(4,5-d)pyrimidine inhibits the reaction [APP gene mutant form results in increased chemical synthesis of Superoxides]; more ... CTD PMID:16212921|PMID:22886847 App Rat superoxide increases chemical synthesis ISO RGD:736021 6480464 APP gene mutant form results in increased chemical synthesis of Superoxides CTD PMID:22886847 App Rat T-2 toxin decreases expression EXP 6480464 T-2 Toxin results in decreased expression of APP mRNA CTD PMID:26141394 App Rat tadalafil multiple interactions ISO RGD:736022 6480464 Tadalafil inhibits the reaction [Streptozocin results in increased expression of APP protein modified form] CTD PMID:34428446 App Rat tamoxifen affects expression ISO RGD:736022 6480464 Tamoxifen affects the expression of APP mRNA CTD PMID:17555576 App Rat tamoxifen decreases expression ISO RGD:736022 6480464 Tamoxifen results in decreased expression of APP mRNA CTD PMID:19400957 App Rat tamoxifen decreases expression EXP 6480464 Tamoxifen results in decreased expression of APP mRNA CTD PMID:19400957 App Rat tauroursodeoxycholic acid multiple interactions EXP 6480464 ursodoxicoltaurine affects the reaction [APP protein modified form affects the localization of NR3C2 protein]; ursodoxicoltaurine more ... CTD PMID:16728529|PMID:18368144 App Rat tauroursodeoxycholic acid multiple interactions ISO RGD:736021 6480464 ursodoxicoltaurine inhibits the reaction [[APP gene mutant form co-treated with PSEN1 gene mutant form] results more ... CTD PMID:16923170 App Rat terbufos increases methylation ISO RGD:736021 6480464 terbufos results in increased methylation of APP promoter CTD PMID:22847954 App Rat tert-butyl hydroperoxide decreases expression ISO RGD:736021 6480464 tert-Butylhydroperoxide results in decreased expression of APP mRNA CTD PMID:12419474 App Rat testosterone enanthate affects expression ISO RGD:736021 6480464 testosterone enanthate affects the expression of APP mRNA CTD PMID:17440010 App Rat tetrachloromethane decreases expression ISO RGD:736022 6480464 Carbon Tetrachloride results in decreased expression of APP mRNA CTD PMID:17484886 App Rat tetrachloromethane increases expression EXP 6480464 Carbon Tetrachloride results in increased expression of APP mRNA CTD PMID:31150632 App Rat tetrachloromethane increases expression ISO RGD:736022 6480464 Carbon Tetrachloride results in increased expression of APP mRNA CTD PMID:27339419|PMID:31919559 App Rat tetracosapentaenoic acid multiple interactions ISO RGD:736022 6480464 [APP protein mutant form co-treated with PSEN1 protein mutant form] results in decreased abundance of more ... CTD PMID:39172838 App Rat tetrahydrocurcumin multiple interactions ISO RGD:736021 6480464 tetrahydrocurcumin inhibits the reaction [APP protein binds to APP protein] CTD PMID:19715544 App Rat tetrathiomolybdate(2-) multiple interactions ISO RGD:736021 6480464 [tetrathiomolybdate binds to APP 5' UTR] which results in decreased expression of APP protein; [tetrathiomolybdate more ... CTD PMID:15681799 App Rat tetrathiomolybdate(2-) affects binding ISO RGD:736021 6480464 tetrathiomolybdate binds to APP 5' UTR CTD PMID:15681799 App Rat tetrodotoxin multiple interactions ISO RGD:736022 6480464 Tetrodotoxin inhibits the reaction [DDT results in increased expression of APP mRNA]; Tetrodotoxin inhibits the more ... CTD PMID:35946953 App Rat tetrodotoxin multiple interactions ISO RGD:736021 6480464 Tetrodotoxin inhibits the reaction [DDT results in increased expression of APP mRNA] CTD PMID:35946953 App Rat thapsigargin increases expression EXP 6480464 Thapsigargin results in increased expression of APP protein CTD PMID:35544339 App Rat thiethylperazine multiple interactions ISO RGD:736022 6480464 [Thiethylperazine results in increased activity of ABCC1 protein] which results in increased export of APP more ... CTD PMID:21881209 App Rat thioacetamide increases expression EXP 6480464 Thioacetamide results in increased expression of APP mRNA CTD PMID:23411599 App Rat thiourea increases uptake ISO RGD:736022 6480464 Thiourea results in increased uptake of APP protein modified form CTD PMID:20637185 App Rat thymoquinone multiple interactions EXP 6480464 thymoquinone inhibits the reaction [[Dietary Fats co-treated with Cholesterol, Dietary] results in increased expression of more ... CTD PMID:28734741 App Rat thyroxine decreases cleavage ISO RGD:736022 6480464 Thyroxine results in decreased cleavage of APP protein CTD PMID:17199430 App Rat thyroxine decreases expression ISO RGD:736022 6480464 Thyroxine results in decreased expression of APP mRNA; Thyroxine results in decreased expression of APP more ... CTD PMID:17199430 App Rat titanium dioxide multiple interactions ISO RGD:736022 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of APP more ... CTD PMID:29950665 App Rat titanium dioxide decreases methylation ISO RGD:736022 6480464 titanium dioxide results in decreased methylation of APP gene CTD PMID:35295148 App Rat titanium dioxide increases methylation ISO RGD:736022 6480464 titanium dioxide results in increased methylation of APP gene CTD PMID:35295148 App Rat titanium dioxide increases expression ISO RGD:736022 6480464 titanium dioxide results in increased expression of APP mRNA CTD PMID:23557971 App Rat tocopherol decreases abundance EXP 6480464 APP protein modified form results in decreased abundance of Tocopherols CTD PMID:25654502 App Rat tocopherol multiple interactions EXP 6480464 resveratrol inhibits the reaction [APP protein modified form results in decreased abundance of Tocopherols] CTD PMID:25654502 App Rat tolfenamic acid multiple interactions ISO RGD:736021 6480464 [lead acetate co-treated with tolfenamic acid] results in decreased expression of APP mRNA; tolfenamic acid more ... CTD PMID:24462621 App Rat tolonium chloride decreases secretion ISO RGD:736022 6480464 Tolonium Chloride results in decreased secretion of APP protein modified form CTD PMID:36027949 App Rat toluene affects expression EXP 6480464 Toluene affects the expression of APP mRNA CTD PMID:21827849 App Rat trans-caffeic acid multiple interactions ISO RGD:736022 6480464 caffeic acid inhibits the reaction [aluminum chloride results in increased expression of APP protein modified more ... CTD PMID:18482095 App Rat trenbolone affects expression EXP 6480464 Trenbolone Acetate analog affects the expression of APP protein modified form CTD PMID:25461682 App Rat trenbolone multiple interactions EXP 6480464 Dihydrotestosterone promotes the reaction [Trenbolone Acetate analog results in increased expression of APP protein modified more ... CTD PMID:25461682 App Rat trenbolone increases expression EXP 6480464 Trenbolone Acetate analog results in increased expression of APP protein modified form CTD PMID:25461682 App Rat triadimefon increases expression EXP 6480464 triadimefon results in increased expression of APP mRNA CTD PMID:19423681 App Rat trichlorfon increases secretion ISO RGD:736021 6480464 Trichlorfon results in increased secretion of APP protein alternative form CTD PMID:11526466 App Rat trichlorfon affects cleavage EXP 6480464 Trichlorfon affects the cleavage of APP protein CTD PMID:11099780|PMID:11822883 App Rat trichlorfon affects metabolic processing EXP 6480464 Trichlorfon affects the metabolism of APP protein CTD PMID:10773217 App Rat trilostane multiple interactions EXP 6480464 trilostane inhibits the reaction [Dihydrotestosterone promotes the reaction [Trenbolone Acetate analog results in increased expression more ... CTD PMID:25461682 App Rat trimellitic anhydride decreases expression ISO RGD:736022 6480464 trimellitic anhydride results in decreased expression of APP mRNA CTD PMID:19042947 App Rat triolein multiple interactions EXP 6480464 Triolein inhibits the reaction [[Dietary Fats co-treated with Cholesterol, Dietary] results in increased expression of more ... CTD PMID:28734741 App Rat triphenyl phosphate increases expression EXP 6480464 triphenyl phosphate results in increased expression of APP mRNA CTD PMID:30589522 App Rat triphenyl phosphate affects expression ISO RGD:736021 6480464 triphenyl phosphate affects the expression of APP mRNA CTD PMID:37042841 App Rat tris(2-butoxyethyl) phosphate affects expression ISO RGD:736021 6480464 tris(2-butoxyethyl) phosphate affects the expression of APP mRNA CTD PMID:29024780 App Rat troglitazone increases expression ISO RGD:736021 6480464 troglitazone results in increased expression of APP mRNA CTD PMID:19140230 App Rat tubocurarine multiple interactions ISO RGD:736021 6480464 Tubocurarine inhibits the reaction [[Nicotine results in increased metabolism of APP protein] which results in more ... CTD PMID:29618714 App Rat tunicamycin multiple interactions ISO RGD:736021 6480464 [Tunicamycin co-treated with APP protein modified form] results in increased expression of PSEN1 mRNA; ATF4 more ... CTD PMID:22115781 App Rat tunicamycin increases secretion ISO RGD:736021 6480464 Tunicamycin results in increased secretion of APP protein modified form CTD PMID:22115781 App Rat tyrosine multiple interactions ISO RGD:736021 6480464 PF-06840003 inhibits the reaction [APP protein mutant form results in decreased abundance of Tyrosine] CTD PMID:39172838 App Rat tyrosine decreases abundance ISO RGD:736021 6480464 APP protein mutant form results in decreased abundance of Tyrosine CTD PMID:39172838 App Rat uracil decreases abundance ISO RGD:736021 6480464 APP protein mutant form results in decreased abundance of Uracil CTD PMID:39172838 App Rat uracil multiple interactions ISO RGD:736021 6480464 PF-06840003 inhibits the reaction [APP protein mutant form results in decreased abundance of Uracil] CTD PMID:39172838 App Rat uranium atom affects expression ISO RGD:736021 6480464 Uranium affects the expression of APP mRNA CTD PMID:15672453 App Rat urethane increases expression ISO RGD:736021 6480464 Urethane results in increased expression of APP mRNA CTD PMID:28818685 App Rat ursolic acid multiple interactions ISO RGD:736021 6480464 Ursolic Acid inhibits the reaction [APP protein modified form results in decreased expression of RPT-3 more ... CTD PMID:34902447 App Rat valdecoxib increases expression EXP 6480464 valdecoxib results in increased expression of APP mRNA CTD PMID:24136188 App Rat valine increases abundance ISO RGD:736021 6480464 APP protein mutant form results in increased abundance of Valine CTD PMID:39172838 App Rat valine multiple interactions ISO RGD:736022 6480464 [APP protein mutant form co-treated with PSEN1 protein mutant form] results in increased abundance of more ... CTD PMID:39172838 App Rat valine multiple interactions ISO RGD:736021 6480464 PF-06840003 inhibits the reaction [APP protein mutant form results in increased abundance of Valine] CTD PMID:39172838 App Rat valproic acid increases expression ISO RGD:736022 6480464 Valproic Acid results in increased expression of APP mRNA CTD PMID:22045034 App Rat valproic acid increases expression ISO RGD:736021 6480464 Valproic Acid results in increased expression of APP mRNA CTD PMID:23179753|PMID:27188386|PMID:30008028 App Rat vinclozolin affects expression EXP 6480464 vinclozolin affects the expression of APP mRNA CTD PMID:19015723 App Rat vitamin E decreases expression ISO RGD:736021 6480464 Vitamin E results in decreased expression of APP mRNA CTD PMID:19244175 App Rat vitamin E multiple interactions EXP 6480464 Vitamin E inhibits the reaction [APP protein modified form promotes the reaction [[IFNG protein co-treated more ... CTD PMID:12117551|PMID:15223066 App Rat vitamin E multiple interactions ISO RGD:736022 6480464 Vitamin E inhibits the reaction [Aluminum results in increased cleavage of APP protein] CTD PMID:12039845 App Rat vitexin multiple interactions ISO RGD:736022 6480464 vitexin inhibits the reaction [APP protein modified form results in decreased abundance of Glutathione]; vitexin more ... CTD PMID:29545167 App Rat vitexin decreases expression ISO RGD:736021 6480464 vitexin results in decreased expression of APP mRNA; vitexin results in decreased expression of APP more ... CTD PMID:32926499 App Rat WIN 55212-2 multiple interactions ISO RGD:736022 6480464 (3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone inhibits the reaction [APP alternative form results in increased expression of IL6 mRNA] CTD PMID:21350020 App Rat wortmannin increases expression EXP 597931096 [wortmannin cotreatment with isoflurane] increases expression of APP protein in hippocampus RGD App Rat Y-27632 multiple interactions ISO RGD:736022 6480464 ROCK1 protein affects the reaction [Y 27632 affects the cleavage of APP protein] CTD PMID:14615541 App Rat Y-27632 multiple interactions EXP 6480464 Y 27632 inhibits the reaction [aluminum maltolate results in decreased expression of and results in more ... CTD PMID:20395307 App Rat Y-27632 increases secretion EXP 6480464 Y 27632 results in increased secretion of APP protein modified form CTD PMID:19741129 App Rat Y-27632 affects cleavage ISO RGD:736022 6480464 Y 27632 affects the cleavage of APP protein CTD PMID:14615541 App Rat zebularine multiple interactions ISO RGD:736021 6480464 pyrimidin-2-one beta-ribofuranoside inhibits the reaction [Folic Acid results in decreased expression of APP protein] CTD PMID:26492244 App Rat zinc atom multiple interactions ISO RGD:736021 6480464 Clioquinol inhibits the reaction [Zinc results in increased secretion of APP protein alternative form]; Zinc more ... CTD PMID:12572668|PMID:16325427|PMID:16648635|PMID:24855651|PMID:25835329 App Rat zinc atom increases expression EXP 6480464 Zinc deficiency results in increased expression of APP mRNA CTD PMID:19111725 App Rat zinc atom multiple interactions ISO RGD:736022 6480464 [APP protein co-treated with Zinc] results in increased degradation of GPC1 protein modified form CTD PMID:15677459 App Rat zinc atom increases degradation ISO RGD:736021 6480464 Zinc results in increased degradation of APP protein modified form CTD PMID:18068270 App Rat zinc atom multiple interactions EXP 6480464 [Zinc promotes the reaction [APP protein binds to APP protein]] which affects the transport of more ... CTD PMID:16674922 App Rat zinc atom increases secretion ISO RGD:736021 6480464 Zinc results in increased secretion of APP protein alternative form CTD PMID:16648635 App Rat zinc atom affects binding ISO RGD:736021 6480464 APP protein binds to Zinc; APP protein modified form binds to Zinc; Zinc binds to more ... CTD PMID:15699049|PMID:16266835|PMID:16404590|PMID:17119284|PMID:24855651 App Rat zinc sulfate multiple interactions EXP 6480464 Melatonin promotes the reaction [Zinc Sulfate inhibits the reaction [Aluminum Chloride results in increased expression more ... CTD PMID:35526705 App Rat zinc(0) multiple interactions ISO RGD:736021 6480464 Clioquinol inhibits the reaction [Zinc results in increased secretion of APP protein alternative form]; Zinc more ... CTD PMID:12572668|PMID:16325427|PMID:16648635|PMID:24855651|PMID:25835329 App Rat zinc(0) affects binding ISO RGD:736021 6480464 APP protein binds to Zinc; APP protein modified form binds to Zinc; Zinc binds to more ... CTD PMID:15699049|PMID:16266835|PMID:16404590|PMID:17119284|PMID:24855651 App Rat zinc(0) increases secretion ISO RGD:736021 6480464 Zinc results in increased secretion of APP protein alternative form CTD PMID:16648635 App Rat zinc(0) multiple interactions EXP 6480464 [Zinc promotes the reaction [APP protein binds to APP protein]] which affects the transport of more ... CTD PMID:16674922 App Rat zinc(0) increases degradation ISO RGD:736021 6480464 Zinc results in increased degradation of APP protein modified form CTD PMID:18068270 App Rat zinc(0) multiple interactions ISO RGD:736022 6480464 [APP protein co-treated with Zinc] results in increased degradation of GPC1 protein modified form CTD PMID:15677459 App Rat zinc(0) increases expression EXP 6480464 Zinc deficiency results in increased expression of APP mRNA CTD PMID:19111725