App (amyloid beta precursor protein) - Rat Genome Database

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Gene: App (amyloid beta precursor protein) Rattus norvegicus
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Symbol: App
Name: amyloid beta precursor protein
RGD ID: 2139
Description: Exhibits growth factor receptor binding activity and peptidase activator activity. Involved in several processes, including cellular response to metal ion; defense response to other organism; and positive regulation of MAPK cascade. Localizes to several cellular components, including astrocyte projection; axon; and rough endoplasmic reticulum. Predicted to colocalize with several cellular components, including cell body; low-density lipoprotein particle; and very-low-density lipoprotein particle. Used to study Alzheimer's disease. Biomarker of Alzheimer's disease; diabetic encephalopathy; hypertension; iron deficiency anemia; and middle cerebral artery infarction. Human ortholog(s) of this gene implicated in APP-related cerebral amyloid angiopathy; Alzheimer's disease; Alzheimer's disease 1; cognitive disorder; and visual epilepsy. Orthologous to human APP (amyloid beta precursor protein); PARTICIPATES IN glypican signaling pathway; Alzheimer's disease pathway; INTERACTS WITH (+)-catechin; (S)-naringenin; (S)-nicotine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: Abeta; ABPP; AG; alzheimer disease amyloid A4 protein homolog; amyloid A4; amyloid beta (A4) precursor protein; amyloid beta A4 protein; amyloidogenic glycoprotein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Appem1Sage  
Genetic Models: SD-Appem1Sage
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21124,019,774 - 24,236,584 (-)NCBI
Rnor_6.0 Ensembl1124,425,005 - 24,641,858 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01124,425,013 - 24,641,872 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01128,048,897 - 28,265,250 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41124,457,855 - 24,693,851 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11124,457,854 - 24,693,851 (-)NCBI
Celera1123,853,696 - 24,069,048 (-)NCBICelera
RH 3.4 Map1194.7RGD
Cytogenetic Map11q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-alpha-tocopherol  (ISO)
(+)-catechin  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
(24S)-24-hydroxycholesterol  (ISO)
(25R)-cholest-5-ene-3beta,26-diol  (ISO)
(5Z,8Z,11Z,13E)-15-HETE  (ISO)
(R)-carnitine  (ISO)
(S)-naringenin  (EXP)
(S)-nicotine  (EXP,ISO)
(Z)-ligustilide  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (EXP,ISO)
1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,2,2-tetramine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3-dihydroxybenzoic acid  (ISO)
2,4-dinitrophenol  (ISO)
2,5-dihydroxybenzoic acid  (ISO)
2,6-dinitrotoluene  (EXP)
2-deoxy-D-glucose  (ISO)
2-ethoxyethanol  (EXP)
2-methoxyethanol  (EXP)
26-hydroxycholesterol  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP,ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3,4-dihydroxybenzoic acid  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-methyladenine  (ISO)
3-nitrophenol  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,7-diphenyl-1,10-phenanthroline  (ISO)
4-hydroxynon-2-enal  (ISO)
4-phenylbutyric acid  (EXP)
5,6,7,8-tetrahydrobiopterin  (ISO)
5-azacytidine  (ISO)
5-chloro-7-iodoquinolin-8-ol  (ISO)
7alpha-hydroxycholesterol  (EXP)
8-epi-prostaglandin F2alpha  (ISO)
9-cis-retinoic acid  (ISO)
acetamide  (EXP)
acetyl-CoA  (ISO)
acetylcholine  (EXP,ISO)
acrolein  (EXP,ISO)
aflatoxin B1  (EXP,ISO)
agmatine  (ISO)
AICA ribonucleotide  (ISO)
alendronic acid  (ISO)
all-trans-retinoic acid  (EXP,ISO)
all-trans-retinol  (EXP)
alpha-hexachlorocyclohexane  (EXP)
alpha-pinene  (ISO)
aluminium atom  (EXP,ISO)
aluminium sulfate (anhydrous)  (ISO)
aluminium(0)  (EXP,ISO)
ambenonium chloride  (EXP)
aminoguanidine  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
anandamide  (EXP,ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
arachidonic acid  (ISO)
aristolochic acid  (ISO)
Aroclor 1254  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenous acid  (ISO)
astaxanthin  (ISO)
atorvastatin calcium  (ISO)
ATP  (ISO)
atrazine  (EXP)
azure B  (ISO)
baicalein  (EXP)
benzene  (ISO)
benzo[a]pyrene  (ISO)
berberine  (EXP)
bethanechol  (EXP)
bexarotene  (EXP)
bilobalide  (ISO)
biotin  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bisdemethoxycurcumin  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
buspirone  (EXP)
buten-2-one  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (ISO)
calcium atom  (EXP,ISO)
calcium(0)  (EXP,ISO)
cannabidiol  (ISO)
carbachol  (ISO)
carbon nanotube  (ISO)
carnosine  (ISO)
carvedilol  (ISO)
celecoxib  (ISO)
chloropicrin  (ISO)
chloroquine  (EXP)
chlorpyrifos  (ISO)
cholesterol  (EXP,ISO)
choline  (ISO)
cilostazol  (ISO)
cis-caffeic acid  (ISO)
clofibrate  (EXP)
clofibric acid  (EXP)
cobalt atom  (ISO)
cobalt dichloride  (ISO)
cocaine  (EXP,ISO)
coenzyme Q10  (EXP)
Congo Red  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (EXP,ISO)
cordycepin  (EXP)
coumestrol  (ISO)
creatine  (ISO)
crocidolite asbestos  (ISO)
CTP  (ISO)
curcumin  (EXP,ISO)
cyclosporin A  (ISO)
cyprodinil  (ISO)
D-penicillamine  (ISO)
DAPT  (ISO)
DDE  (ISO)
DDT  (ISO)
decabromodiphenyl ether  (EXP,ISO)
demethoxycurcumin  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (EXP)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dichlorvos  (EXP,ISO)
dieldrin  (EXP)
diethyldithiocarbamic acid  (ISO)
dihydrogen  (ISO)
dimercaprol  (ISO)
dimethylarsinic acid  (ISO)
diminazene diaceturate  (ISO)
diprotium  (ISO)
disodium selenite  (ISO)
disulfiram  (ISO)
diuron  (EXP)
donepezil hydrochloride  (EXP,ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
DPCPX  (EXP)
duvoglustat  (ISO)
edaravone  (EXP)
elemental selenium  (ISO)
enzalutamide  (ISO)
ethanol  (ISO)
ethosuximide  (EXP)
ethylenediaminetetraacetic acid  (ISO)
farrerol  (EXP)
fenofibrate  (ISO)
ferroheme b  (ISO)
finasteride  (EXP)
fipronil  (EXP)
fisetin  (ISO)
flurbiprofen  (EXP,ISO)
flutamide  (EXP)
folic acid  (ISO)
folpet  (ISO)
fonofos  (ISO)
fulvestrant  (EXP)
fumonisin B1  (ISO)
furan  (EXP)
galanthamine  (ISO)
galanthamine Trifluoroacetic acid  (ISO)
gallic acid  (ISO)
gamma-tocopherol  (EXP)
genistein  (ISO)
gentamycin  (EXP)
ginkgolide B  (ISO)
Ginkgolide C  (ISO)
ginsenoside Rd  (EXP)
ginsenoside Rg1  (EXP)
ginsenoside Rg2  (EXP)
glutathione  (EXP,ISO)
glycine betaine  (ISO)
glycitin  (EXP)
glyphosate  (ISO)
Goe 6976  (ISO)
GTP  (ISO)
GW 501516  (ISO)
heme b  (ISO)
heparin  (ISO)
heroin  (ISO)
hexaconazole  (ISO)
homocysteine  (ISO)
hydrogen peroxide  (ISO)
ibuprofen  (EXP,ISO)
icariin  (EXP)
idarubicin  (ISO)
indole-3-methanol  (EXP)
indometacin  (EXP,ISO)
iron atom  (ISO)
iron(0)  (ISO)
isoflurane  (ISO)
isoniazide  (ISO)
kaempferol  (EXP)
kojic acid  (ISO)
KT 5720  (ISO)
KT 5823  (ISO)
L-ascorbic acid  (EXP,ISO)
L-erythro-7,8-dihydrobiopterin  (ISO)
L-methionine  (ISO)
L-serine  (EXP)
lactacystin  (ISO)
lead diacetate  (EXP,ISO)
lead tetraacetate  (ISO)
lead(0)  (EXP,ISO)
lead(2+)  (EXP,ISO)
lipopolysaccharide  (EXP,ISO)
lithium atom  (EXP,ISO)
lithium chloride  (ISO)
lithium hydride  (EXP,ISO)
lovastatin  (EXP,ISO)
LY294002  (EXP,ISO)
malonaldehyde  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
Mecamylamine  (ISO)
melatonin  (EXP,ISO)
meloxicam  (ISO)
memantine  (EXP)
mepanipyrim  (ISO)
mercury atom  (ISO)
mercury dichloride  (ISO)
mercury(0)  (ISO)
methamphetamine  (EXP,ISO)
methapyrilene  (EXP)
methotrexate  (ISO)
methyllycaconitine  (EXP,ISO)
Methysticin  (ISO)
minocycline  (EXP,ISO)
miquelianin  (ISO)
mitomycin C  (ISO)
morin  (ISO)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
neoechinulin A  (ISO)
nickel atom  (ISO)
nicotine  (EXP,ISO)
nimodipine  (EXP)
nitric oxide  (ISO)
nitroprusside  (ISO)
notoginsenoside R1  (EXP,ISO)
ochratoxin A  (ISO)
okadaic acid  (ISO)
olanzapine  (EXP)
orlistat  (ISO)
orphenadrine  (EXP)
ozone  (ISO)
p-anisidine  (ISO)
p-menthan-3-ol  (ISO)
paracetamol  (ISO)
paraquat  (EXP,ISO)
parathion  (ISO)
paroxetine  (ISO)
PCB138  (ISO)
pentetrazol  (EXP)
pentobarbital  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (EXP)
PhIP  (ISO)
phlorizin  (ISO)
phorbol 12,13-dibutanoate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosphatidylcholine  (ISO)
phosphoenolpyruvate  (ISO)
physostigmine  (EXP)
pioglitazone  (ISO)
piperidine  (ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP,ISO)
poly(I:C)  (EXP)
potassium atom  (EXP)
potassium bromate  (ISO)
pravastatin  (ISO)
pregnenolone  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP)
proanthocyanidin  (EXP)
probucol  (EXP)
progesterone  (ISO)
propiconazole  (EXP)
prostaglandin D2  (ISO)
prostaglandin E2  (EXP,ISO)
prucalopride  (ISO)
pyrimethanil  (ISO)
pyrogallol  (ISO)
pyrrolidine dithiocarbamate  (ISO)
quercetin  (ISO)
quetiapine fumarate  (EXP)
quinine  (ISO)
raloxifene  (ISO)
reactive nitrogen species  (ISO)
reactive oxygen species  (EXP,ISO)
resveratrol  (EXP,ISO)
rimonabant  (ISO)
rotenone  (ISO)
rottlerin  (EXP)
ruthenium red  (EXP)
S-adenosyl-L-homocysteine  (ISO)
S-adenosyl-L-methioninate  (ISO)
S-adenosyl-L-methionine  (ISO)
salicylates  (EXP)
sapropterin  (ISO)
sarin  (ISO)
SB 203580  (ISO)
SB 415286  (ISO)
SCH772984  (EXP)
scopolamine  (ISO)
scutellarin  (EXP)
selenium atom  (ISO)
selenomethionine  (EXP)
serotonin  (ISO)
sevoflurane  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (EXP,ISO)
sirolimus  (ISO)
sirtinol  (ISO)
sodium arsenite  (ISO)
sodium azide  (ISO)
sodium dichromate  (EXP)
sodium nitrite  (ISO)
staurosporine  (ISO)
streptozocin  (EXP,ISO)
sulindac  (ISO)
sulindac sulfide  (EXP,ISO)
superoxide  (ISO)
T-2 toxin  (EXP)
tamoxifen  (EXP,ISO)
tauroursodeoxycholic acid  (EXP,ISO)
terbufos  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP,ISO)
tetrahydrocurcumin  (ISO)
tetrathiomolybdate(2-)  (ISO)
thiethylperazine  (ISO)
thioacetamide  (EXP)
thiourea  (ISO)
thymoquinone  (EXP)
thyroxine  (ISO)
titanium dioxide  (ISO)
tocopherol  (EXP)
tolfenamic acid  (ISO)
toluene  (EXP)
trans-caffeic acid  (ISO)
Trenbolone  (EXP)
triadimefon  (EXP)
trichlorfon  (EXP,ISO)
trilostane  (EXP)
trimellitic anhydride  (ISO)
triolein  (EXP)
triphenyl phosphate  (EXP)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (ISO)
tubocurarine  (ISO)
tunicamycin  (ISO)
uranium atom  (ISO)
urethane  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)
vitamin E  (EXP,ISO)
vitexin  (ISO)
WIN 55212-2  (ISO)
Y-27632  (EXP,ISO)
zebularine  (ISO)
zinc atom  (EXP,ISO)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenylate cyclase-activating G protein-coupled receptor signaling pathway  (ISO)
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway  (ISO)
adult locomotory behavior  (ISO,ISS)
amyloid fibril formation  (ISO)
antibacterial humoral response  (IDA,ISO)
antifungal humoral response  (IDA,ISO)
antimicrobial humoral immune response mediated by antimicrobial peptide  (IDA,ISO)
associative learning  (ISO)
astrocyte activation  (ISO)
astrocyte activation involved in immune response  (ISO)
axo-dendritic transport  (ISO,ISS)
axon midline choice point recognition  (ISO,ISS)
axonogenesis  (ISO,ISS)
calcium-mediated signaling  (ISO)
cell adhesion  (IEA)
cellular copper ion homeostasis  (ISO,ISS)
cellular process  (ISO)
cellular response to amyloid-beta  (IEA,ISO)
cellular response to cAMP  (IEP)
cellular response to copper ion  (IEP)
cellular response to manganese ion  (IEP)
cellular response to nerve growth factor stimulus  (IEP)
cellular response to norepinephrine stimulus  (IMP)
chemical synaptic transmission  (ISO)
cholesterol metabolic process  (ISO)
cognition  (ISO,ISS)
collateral sprouting in absence of injury  (ISO,ISS)
defense response to Gram-negative bacterium  (IDA,ISO)
defense response to Gram-positive bacterium  (IDA,ISO)
dendrite development  (ISO,ISS)
endocytosis  (IEA,ISO,ISS)
extracellular matrix organization  (ISO,ISS)
forebrain development  (ISO)
G protein-coupled receptor signaling pathway  (ISO)
innate immune response  (IDA,ISO)
ionotropic glutamate receptor signaling pathway  (ISO,ISS)
learning  (ISO)
learning or memory  (ISO)
locomotory behavior  (ISO,ISS)
mating behavior  (ISO,ISS)
memory  (ISO)
microglia development  (ISO)
microglial cell activation  (IEA,ISO)
modulation of age-related behavioral decline  (ISO)
modulation of excitatory postsynaptic potential  (ISO)
mRNA polyadenylation  (ISO,ISS)
negative regulation of blood circulation  (ISO)
negative regulation of canonical Wnt signaling pathway  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of endopeptidase activity  (IEA)
negative regulation of gene expression  (ISO)
negative regulation of long-term synaptic potentiation  (ISO)
negative regulation of low-density lipoprotein receptor activity  (ISO)
negative regulation of neuron death  (ISO)
negative regulation of neuron differentiation  (ISO)
negative regulation of pri-miRNA transcription by RNA polymerase II  (ISO)
negative regulation of protein localization to nucleus  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
nervous system development  (IEA)
neuromuscular process controlling balance  (ISO)
neuron apoptotic process  (ISO)
neuron projection development  (ISO,ISS)
neuron projection maintenance  (ISO)
neuron remodeling  (ISO,ISS)
Notch signaling pathway  (IEA)
obsolete activation of MAPK activity  (IDA,IGI)
positive regulation of 1-phosphatidylinositol-3-kinase activity  (ISO)
positive regulation of amyloid fibril formation  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process  (ISO)
positive regulation of cellular response to thapsigargin  (ISO)
positive regulation of cellular response to tunicamycin  (ISO)
positive regulation of chemokine production  (ISO)
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process  (ISO)
positive regulation of DNA-binding transcription factor activity  (ISO)
positive regulation of endothelin production  (ISO)
positive regulation of ERK1 and ERK2 cascade  (IDA,IGI,ISO)
positive regulation of excitatory postsynaptic potential  (ISO)
positive regulation of G protein-coupled receptor internalization  (ISO)
positive regulation of G protein-coupled receptor signaling pathway  (ISO)
positive regulation of G2/M transition of mitotic cell cycle  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of glycolytic process  (ISO)
positive regulation of histone acetylation  (ISO)
positive regulation of inflammatory response  (ISO)
positive regulation of interferon-gamma production  (ISO)
positive regulation of interleukin-1 beta production  (ISO)
positive regulation of interleukin-6 production  (ISO)
positive regulation of JNK cascade  (ISO)
positive regulation of long-term synaptic potentiation  (IEA,ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of membrane protein ectodomain proteolysis  (ISO)
positive regulation of mitotic cell cycle  (ISO,ISS)
positive regulation of monocyte chemotaxis  (ISO)
positive regulation of neuron apoptotic process  (ISO)
positive regulation of neuron death  (ISO)
positive regulation of neuron differentiation  (ISO)
positive regulation of NF-kappaB transcription factor activity  (IEA,ISO)
positive regulation of NIK/NF-kappaB signaling  (ISO)
positive regulation of nitric oxide biosynthetic process  (ISO)
positive regulation of oxidative stress-induced neuron death  (ISO)
positive regulation of peptidase activity  (IEA)
positive regulation of peptidyl-serine phosphorylation  (ISO)
positive regulation of peptidyl-threonine phosphorylation  (ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of phosphorylation  (ISO)
positive regulation of protein binding  (ISO)
positive regulation of protein import  (ISO)
positive regulation of protein metabolic process  (IDA,ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of protein tyrosine kinase activity  (ISO)
positive regulation of receptor binding  (ISO)
positive regulation of response to endoplasmic reticulum stress  (ISO)
positive regulation of superoxide anion generation  (ISO)
positive regulation of T cell migration  (ISO)
positive regulation of tau-protein kinase activity  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response  (ISO)
positive regulation of tumor necrosis factor production  (IEA,ISO)
protein homooligomerization  (ISO)
protein phosphorylation  (ISO,ISS)
protein tetramerization  (ISO)
protein trimerization  (ISO)
regulation of acetylcholine-gated cation channel activity  (ISO)
regulation of amyloid fibril formation  (ISO)
regulation of amyloid-beta clearance  (ISO)
regulation of calcium ion transmembrane transport via high voltage-gated calcium channel  (ISO)
regulation of dendritic spine maintenance  (ISO)
regulation of epidermal growth factor-activated receptor activity  (ISO,ISS)
regulation of gene expression  (ISO)
regulation of long-term neuronal synaptic plasticity  (ISO)
regulation of multicellular organism growth  (ISO,ISS)
regulation of peptidyl-tyrosine phosphorylation  (ISO)
regulation of presynapse assembly  (ISO)
regulation of protein binding  (ISO)
regulation of response to calcium ion  (IGI)
regulation of spontaneous synaptic transmission  (ISO)
regulation of synapse structure or activity  (ISO,ISS)
regulation of toll-like receptor signaling pathway  (ISO)
regulation of transcription by RNA polymerase II  (ISO)
regulation of translation  (ISO,ISS)
response to auditory stimulus  (ISO)
response to interleukin-1  (IDA)
response to lead ion  (IEP)
response to oxidative stress  (ISO)
response to radiation  (IEP)
response to yeast  (IDA,ISO)
smooth endoplasmic reticulum calcium ion homeostasis  (ISO)
suckling behavior  (ISO)
synapse organization  (ISO)
synaptic assembly at neuromuscular junction  (ISO)
visual learning  (ISO,ISS)

Cellular Component
amyloid-beta complex  (ISO)
apical part of cell  (ISO)
astrocyte projection  (IDA)
axon  (IDA,ISO,ISS)
cell body  (ISO)
cell surface  (IDA,IEA,ISO)
cell-cell junction  (ISO)
ciliary rootlet  (ISO)
clathrin-coated pit  (IEA)
COPII-coated ER to Golgi transport vesicle  (ISO)
cytoplasm  (IDA,ISO,ISS)
cytoplasmic vesicle  (ISO)
dendrite  (ISO)
dendrite membrane  (ISO)
dendritic shaft  (ISO)
dendritic spine  (ISO)
early endosome  (IEA,ISO,ISS)
endoplasmic reticulum  (ISO)
endosome  (ISO)
endosome to plasma membrane transport vesicle  (ISO)
extracellular space  (IDA,ISO)
extrinsic component of external side of plasma membrane  (ISO)
Golgi apparatus  (IDA,ISO,ISS)
Golgi-associated vesicle  (IEA,ISO,ISS)
growth cone  (IDA,IEA)
growth cone filopodium  (IDA)
growth cone lamellipodium  (IDA)
high-density lipoprotein particle  (ISO)
integral component of membrane  (IEA,ISO,ISS)
intermediate-density lipoprotein particle  (ISO)
lipoprotein particle  (ISO)
low-density lipoprotein particle  (ISO)
lysosome  (ISO)
main axon  (IDA)
membrane  (ISO)
membrane raft  (IDA,ISO)
mitochondrion  (ISO)
neuromuscular junction  (ISO)
neuron projection  (IDA,ISO)
nuclear envelope lumen  (ISO)
nucleus  (ISO)
perikaryon  (IEA)
perinuclear region of cytoplasm  (ISO)
plasma membrane  (IDA,ISO)
postsynapse  (ISO)
presynapse  (ISO)
presynaptic active zone  (ISO)
protein-containing complex  (ISO)
receptor complex  (ISO)
recycling endosome  (ISO,ISS)
rough endoplasmic reticulum  (IDA)
smooth endoplasmic reticulum  (IEA)
spindle midzone  (ISO)
synapse  (ISO)
synaptic membrane  (ISO)
synaptic vesicle  (IDA,ISO)
terminal bouton  (HDA)
very-low-density lipoprotein particle  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
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Additional References at PubMed
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Genomics

Candidate Gene Status
App is a candidate Gene for QTL Edcs1
Comparative Map Data
App
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21124,019,774 - 24,236,584 (-)NCBI
Rnor_6.0 Ensembl1124,425,005 - 24,641,858 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01124,425,013 - 24,641,872 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01128,048,897 - 28,265,250 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41124,457,855 - 24,693,851 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11124,457,854 - 24,693,851 (-)NCBI
Celera1123,853,696 - 24,069,048 (-)NCBICelera
RH 3.4 Map1194.7RGD
Cytogenetic Map11q11NCBI
APP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2125,880,550 - 26,171,128 (-)EnsemblGRCh38hg38GRCh38
GRCh382125,880,550 - 26,171,128 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372127,252,861 - 27,543,446 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362126,174,732 - 26,465,003 (-)NCBINCBI36hg18NCBI36
Build 342126,174,732 - 26,465,003NCBI
Celera2112,436,275 - 12,726,567 (-)NCBI
Cytogenetic Map21q21.3NCBI
HuRef2112,656,350 - 12,947,965 (-)NCBIHuRef
CHM1_12126,813,502 - 27,104,969 (-)NCBICHM1_1
App
(Mus musculus - house mouse)