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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2139
Species: Rattus norvegicus
RGD Object: Gene
Symbol: App
Name: amyloid beta precursor protein
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Appdecreases expressionEXP 6480464CTDbisphenol A results in decreased expression of APP mRNAPMID:34947998
Appincreases expressionEXP 6480464CTDbisphenol A results in increased expression of APP mRNA; bisphenol A results in increased expression of APP protein modified formPMID:25181051 PMID:35648353
Appmultiple interactionsEXP 6480464CTD[bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in decreased expression of APP mRNAPMID:36041667
Appdecreases expressionISOAPP (Homo sapiens)6480464CTDbisphenol A results in decreased expression of APP proteinPMID:37567409
Appdecreases methylationISOAPP (Homo sapiens)6480464CTDbisphenol A results in decreased methylation of APP genePMID:31601247
Appincreases expressionISOApp (Mus musculus)6480464CTDbisphenol A results in increased expression of APP mRNA; bisphenol A results in increased expression of APP proteinPMID:26063408 PMID:26779933 PMID:26923231
Appmultiple interactionsISOAPP (Homo sapiens)6480464CTD[bisphenol A co-treated with Fulvestrant] results in decreased methylation of APP genePMID:31601247
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