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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2139
Species: Rattus norvegicus
RGD Object: Gene
Symbol: App
Name: amyloid beta precursor protein
Acc ID: CHEBI:16170
Term: mercury(0)
Definition: Elemental mercury of oxidation state zero.
Chemical ID: MESH:D008628
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Appincreases secretionISOAPP (Homo sapiens)6480464CTDMercury results in increased secretion of APP protein alternative form; Mercury results in increased secretion of APP protein modified formPMID:12182891 PMID:25673500
Appmultiple interactionsISOAPP (Homo sapiens)6480464CTDEstradiol inhibits the reaction [Mercury results in increased secretion of APP protein modified form]PMID:12182891
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