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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2139
Species: Rattus norvegicus
RGD Object: Gene
Symbol: App
Name: amyloid beta precursor protein
Acc ID: CHEBI:64017
Term: (5Z,8Z,11Z,13E)-15-HETE
Definition: A HETE that is (5Z,8Z,11Z,13E)-15-hydroxyicosa-5,8,11,13-tetraenoic acid bearing a hydroxy substituent at position 15.
Chemical ID: MESH:C025984
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Appincreases secretionISORGD:7360216480464CTDAPP protein modified form results in increased secretion of 15-hydroxy-5 8 11 13-eicosatetraenoic acid

PMID:28721267
Appmultiple interactionsISORGD:7360216480464CTDCNB 001 inhibits the reaction [APP protein modified form results in increased secretion of 15-hydroxy-5 8 11 13-eicosatetraenoic acid] Dronabinol inhibits the reaction [APP protein modified form results in increased secretion of 15-hydroxy-5 8 11 13-eicosatetraenoic acid] L 685458 inhibits the reaction [APP protein modified form results in increased secretion of 15-hydroxy-5 8 11 13-eicosatetraenoic acid]

PMID:28721267
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