App (amyloid beta (A4) precursor protein) - Rat Genome Database

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Gene: App (amyloid beta (A4) precursor protein) Mus musculus
Symbol: App
Name: amyloid beta (A4) precursor protein
RGD ID: 736022
Description: Exhibits RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; low-density lipoprotein particle receptor binding activity; and signaling receptor activator activity. Involved in several processes, including cellular metal ion homeostasis; nervous system development; and regulation of gene expression. Localizes to several cellular components, including cytoplasmic vesicle; cytoskeleton; and neuromuscular junction. Predicted to colocalize with several cellular components, including high-density lipoprotein particle; low-density lipoprotein particle; and triglyceride-rich plasma lipoprotein particle. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; neurogenic placode; and sensory organ. Used to study Alzheimer's disease. Human ortholog(s) of this gene implicated in APP-related cerebral amyloid angiopathy; Alzheimer's disease; Alzheimer's disease 1; cognitive disorder; and visual epilepsy. Orthologous to human APP (amyloid beta precursor protein); PARTICIPATES IN glypican signaling pathway; Alzheimer's disease pathway; INTERACTS WITH (S)-nicotine; (Z)-ligustilide; 1,2-dimethylhydrazine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: A; Abe; Abeta; Abpp; Adap; Ag; AL024401; alzheimer disease amyloid A4 protein homolog; amyloid beta A4 protein; amyloidogenic glycoprotein; appican; bet; betaAPP; C; Cvap; E030013M08Rik; protease nexin II
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391684,751,236 - 84,972,187 (-)NCBIGRCm39mm39
GRCm39 Ensembl1684,746,573 - 84,970,654 (-)Ensembl
GRCm381684,952,666 - 85,175,255 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1684,949,685 - 85,173,766 (-)EnsemblGRCm38mm10GRCm38
MGSCv371684,954,688 - 85,173,948 (-)NCBIGRCm37mm9NCBIm37
MGSCv361684,837,873 - 85,057,149 (-)NCBImm8
Celera1685,161,866 - 85,382,753 (-)NCBICelera
Cytogenetic Map16C3.3NCBI
cM Map1646.92NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-alpha-tocopherol  (ISO)
(+)-catechin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(24S)-24-hydroxycholesterol  (ISO)
(25R)-cholest-5-ene-3beta,26-diol  (ISO)
(5Z,8Z,11Z,13E)-15-HETE  (ISO)
(R)-carnitine  (ISO)
(S)-naringenin  (ISO)
(S)-nicotine  (EXP,ISO)
(Z)-ligustilide  (EXP)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dimethylhydrazine  (EXP)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (EXP,ISO)
1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,2,2-tetramine  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,3-dihydroxybenzoic acid  (ISO)
2,4-dinitrophenol  (EXP)
2,5-dihydroxybenzoic acid  (ISO)
2,6-dinitrotoluene  (ISO)
2-deoxy-D-glucose  (ISO)
2-ethoxyethanol  (ISO)
2-methoxyethanol  (ISO)
26-hydroxycholesterol  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3,4-dihydroxybenzoic acid  (ISO)
3-chloropropane-1,2-diol  (ISO)
3-methyladenine  (ISO)
3-nitrophenol  (EXP)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,7-diphenyl-1,10-phenanthroline  (ISO)
4-hydroxynon-2-enal  (ISO)
4-phenylbutyric acid  (ISO)
5,6,7,8-tetrahydrobiopterin  (ISO)
5-azacytidine  (EXP)
5-chloro-7-iodoquinolin-8-ol  (ISO)
7alpha-hydroxycholesterol  (ISO)
8-epi-prostaglandin F2alpha  (ISO)
9-cis-retinoic acid  (ISO)
acetamide  (ISO)
acetyl-CoA  (EXP,ISO)
acetylcholine  (EXP,ISO)
acrolein  (EXP,ISO)
aflatoxin B1  (EXP,ISO)
agmatine  (EXP)
AICA ribonucleotide  (ISO)
alendronic acid  (EXP)
all-trans-retinoic acid  (ISO)
all-trans-retinol  (ISO)
alpha-hexachlorocyclohexane  (ISO)
alpha-pinene  (ISO)
aluminium atom  (EXP,ISO)
aluminium sulfate (anhydrous)  (EXP,ISO)
aluminium(0)  (EXP,ISO)
ambenonium chloride  (ISO)
aminoguanidine  (ISO)
amitrole  (ISO)
ammonium chloride  (ISO)
anandamide  (EXP,ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
arachidonic acid  (ISO)
Aroclor 1254  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
astaxanthin  (EXP)
atorvastatin calcium  (EXP)
atrazine  (ISO)
azure B  (ISO)
baicalein  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
berberine  (ISO)
bethanechol  (ISO)
bexarotene  (ISO)
bilobalide  (ISO)
biotin  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bisdemethoxycurcumin  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
buspirone  (ISO)
buten-2-one  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calcium atom  (EXP,ISO)
calcium(0)  (EXP,ISO)
cannabidiol  (EXP,ISO)
carbachol  (EXP)
carbon nanotube  (EXP,ISO)
carnosine  (EXP)
carvedilol  (EXP)
celecoxib  (EXP)
chloropicrin  (ISO)
chloroquine  (ISO)
chlorpyrifos  (EXP)
cholesterol  (EXP,ISO)
choline  (EXP)
cilostazol  (EXP)
cis-caffeic acid  (EXP)
clofibrate  (ISO)
clofibric acid  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (ISO)
cocaine  (ISO)
coenzyme Q10  (ISO)
Congo Red  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (EXP,ISO)
cordycepin  (ISO)
coumestrol  (ISO)
creatine  (ISO)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
cyprodinil  (ISO)
D-penicillamine  (ISO)
decabromodiphenyl ether  (ISO)
demethoxycurcumin  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (ISO)
dextran sulfate  (EXP)
diarsenic trioxide  (ISO)
dichlorvos  (ISO)
dieldrin  (ISO)
diethyldithiocarbamic acid  (ISO)
dihydrogen  (ISO)
dimercaprol  (ISO)
dimethylarsinic acid  (EXP,ISO)
diminazene diaceturate  (EXP)
diprotium  (ISO)
disodium selenite  (EXP)
disulfiram  (ISO)
diuron  (ISO)
donepezil hydrochloride  (EXP,ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
duvoglustat  (EXP)
edaravone  (ISO)
elemental selenium  (ISO)
ethanol  (EXP)
ethosuximide  (ISO)
ethylenediaminetetraacetic acid  (ISO)
farrerol  (ISO)
fenofibrate  (ISO)
ferroheme b  (ISO)
finasteride  (ISO)
fipronil  (ISO)
fisetin  (EXP)
flurbiprofen  (EXP,ISO)
flutamide  (ISO)
folic acid  (EXP,ISO)
folpet  (EXP)
fonofos  (ISO)
fulvestrant  (ISO)
fumonisin B1  (EXP)
furan  (ISO)
galanthamine  (EXP)
galanthamine Trifluoroacetic acid  (EXP)
gallic acid  (ISO)
gamma-tocopherol  (ISO)
genistein  (EXP)
gentamycin  (ISO)
ginkgolide B  (ISO)
Ginkgolide C  (ISO)
ginsenoside Rd  (ISO)
ginsenoside Rg1  (ISO)
ginsenoside Rg2  (ISO)
glutathione  (EXP,ISO)
glycine betaine  (EXP)
glycitin  (ISO)
glyphosate  (ISO)
Goe 6976  (ISO)
GW 501516  (ISO)
heme b  (ISO)
heparin  (ISO)
heroin  (ISO)
hexaconazole  (EXP)
homocysteine  (EXP)
hydrogen peroxide  (ISO)
ibuprofen  (EXP,ISO)
icariin  (ISO)
idarubicin  (EXP)
indole-3-methanol  (ISO)
indometacin  (EXP,ISO)
iron atom  (ISO)
iron(0)  (ISO)
isoflurane  (ISO)
isoniazide  (ISO)
kaempferol  (ISO)
kojic acid  (ISO)
KT 5720  (EXP)
KT 5823  (ISO)
L-ascorbic acid  (ISO)
L-erythro-7,8-dihydrobiopterin  (ISO)
L-methionine  (EXP)
lactacystin  (ISO)
lead diacetate  (EXP,ISO)
lead tetraacetate  (EXP)
lead(0)  (EXP,ISO)
lead(2+)  (EXP,ISO)
lipopolysaccharide  (EXP,ISO)
lithium atom  (EXP,ISO)
lithium chloride  (ISO)
lithium hydride  (EXP,ISO)
lovastatin  (ISO)
LY294002  (ISO)
malonaldehyde  (EXP)
manganese atom  (ISO)
manganese(0)  (ISO)
Mecamylamine  (ISO)
melatonin  (EXP,ISO)
meloxicam  (EXP)
memantine  (ISO)
mepanipyrim  (ISO)
mercury atom  (ISO)
mercury dichloride  (ISO)
mercury(0)  (ISO)
methamphetamine  (ISO)
methapyrilene  (ISO)
methotrexate  (ISO)
methyllycaconitine  (EXP,ISO)
Methysticin  (EXP)
minocycline  (EXP,ISO)
miquelianin  (ISO)
mitomycin C  (ISO)
morin  (ISO)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (ISO)
neoechinulin A  (EXP)
nickel atom  (ISO)
nicotine  (EXP,ISO)
nimodipine  (ISO)
nitric oxide  (EXP)
nitroprusside  (EXP)
notoginsenoside R1  (EXP,ISO)
ochratoxin A  (ISO)
okadaic acid  (EXP)
olanzapine  (ISO)
orlistat  (ISO)
orphenadrine  (ISO)
ozone  (EXP,ISO)
p-anisidine  (EXP)
p-menthan-3-ol  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
parathion  (ISO)
paroxetine  (ISO)
PCB138  (EXP)
pentetrazol  (ISO)
pentobarbital  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
phlorizin  (EXP)
phorbol 12,13-dibutanoate  (ISO)
phorbol 13-acetate 12-myristate  (EXP)
phosphatidylcholine  (ISO)
phosphoenolpyruvate  (ISO)
physostigmine  (ISO)
pioglitazone  (EXP,ISO)
piperidine  (ISO)
piperonyl butoxide  (ISO)
pirinixic acid  (EXP,ISO)
poly(I:C)  (ISO)
potassium atom  (ISO)
potassium bromate  (ISO)
pravastatin  (ISO)
pregnenolone  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
proanthocyanidin  (ISO)
probucol  (ISO)
progesterone  (EXP)
propiconazole  (ISO)
prostaglandin D2  (ISO)
prostaglandin E2  (EXP,ISO)
prucalopride  (EXP)
pyrimethanil  (ISO)
pyrogallol  (ISO)
pyrrolidine dithiocarbamate  (EXP)
quercetin  (ISO)
quetiapine fumarate  (ISO)
quinine  (ISO)
raloxifene  (ISO)
reactive nitrogen species  (EXP)
reactive oxygen species  (EXP,ISO)
resveratrol  (EXP,ISO)
rimonabant  (EXP)
rotenone  (ISO)
rottlerin  (ISO)
ruthenium red  (ISO)
S-adenosyl-L-homocysteine  (EXP)
S-adenosyl-L-methioninate  (ISO)
S-adenosyl-L-methionine  (ISO)
salicylates  (ISO)
sapropterin  (ISO)
sarin  (ISO)
SB 203580  (ISO)
SB 415286  (ISO)
SCH772984  (ISO)
scopolamine  (EXP)
scutellarin  (ISO)
selenium atom  (ISO)
selenomethionine  (ISO)
serotonin  (ISO)
sevoflurane  (EXP,ISO)
silicon dioxide  (EXP,ISO)
silver atom  (EXP)
silver(0)  (EXP)
simvastatin  (ISO)
sirolimus  (EXP,ISO)
sirtinol  (EXP)
sodium arsenite  (EXP,ISO)
sodium azide  (ISO)
sodium dichromate  (ISO)
sodium nitrite  (ISO)
staurosporine  (ISO)
streptozocin  (EXP,ISO)
sulindac  (ISO)
sulindac sulfide  (EXP,ISO)
superoxide  (ISO)
T-2 toxin  (ISO)
tamoxifen  (EXP,ISO)
tauroursodeoxycholic acid  (ISO)
terbufos  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP,ISO)
tetrahydrocurcumin  (ISO)
tetrathiomolybdate(2-)  (ISO)
thiethylperazine  (EXP)
thioacetamide  (ISO)
thiourea  (EXP)
thymoquinone  (ISO)
thyroxine  (EXP)
titanium dioxide  (EXP)
tocopherol  (ISO)
tolfenamic acid  (ISO)
toluene  (ISO)
trans-caffeic acid  (EXP)
Trenbolone  (ISO)
triadimefon  (ISO)
trichlorfon  (ISO)
trilostane  (ISO)
trimellitic anhydride  (EXP)
triolein  (ISO)
triphenyl phosphate  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (ISO)
tubocurarine  (ISO)
tunicamycin  (ISO)
uranium atom  (ISO)
urethane  (ISO)
valdecoxib  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (ISO)
vitamin E  (EXP,ISO)
vitexin  (EXP,ISO)
WIN 55212-2  (EXP)
Y-27632  (EXP,ISO)
zebularine  (ISO)
zinc atom  (EXP,ISO)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of MAPK activity  (ISO)
activation of MAPKKK activity  (ISO)
adenylate cyclase-activating G protein-coupled receptor signaling pathway  (ISO)
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway  (ISO)
adult locomotory behavior  (IMP)
amyloid fibril formation  (ISO)
antibacterial humoral response  (ISO)
antifungal humoral response  (ISO)
antimicrobial humoral immune response mediated by antimicrobial peptide  (ISO)
apoptotic process  (IEA)
associative learning  (ISO)
astrocyte activation  (ISO)
astrocyte activation involved in immune response  (ISO)
axo-dendritic transport  (IGI,IMP)
axon midline choice point recognition  (IMP)
axonogenesis  (IMP)
calcium-mediated signaling  (ISO)
cell adhesion  (IEA)
cellular copper ion homeostasis  (IGI,IMP)
cellular process  (ISO)
cellular response to amyloid-beta  (ISO)
cellular response to cAMP  (ISO)
cellular response to copper ion  (ISO)
cellular response to manganese ion  (ISO)
cellular response to nerve growth factor stimulus  (ISO)
cellular response to norepinephrine stimulus  (ISO)
chemical synaptic transmission  (ISO)
cholesterol metabolic process  (IGI,IMP)
cognition  (IDA)
collateral sprouting in absence of injury  (IGI)
defense response to Gram-negative bacterium  (ISO)
defense response to Gram-positive bacterium  (ISO)
dendrite development  (IGI,IMP)
endocytosis  (IMP)
extracellular matrix organization  (IGI)
forebrain development  (IGI,IMP)
G protein-coupled receptor signaling pathway  (ISO)
innate immune response  (ISO)
ionotropic glutamate receptor signaling pathway  (IMP)
learning  (ISO)
learning or memory  (ISO)
locomotory behavior  (IGI)
long-term synaptic potentiation  (TAS)
mating behavior  (IGI)
memory  (ISO,TAS)
microglia development  (ISO)
microglial cell activation  (ISO)
modulation of age-related behavioral decline  (ISO)
modulation of excitatory postsynaptic potential  (ISO)
mRNA polyadenylation  (IDA)
negative regulation of blood circulation  (IGI,ISO)
negative regulation of canonical Wnt signaling pathway  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of long-term synaptic potentiation  (ISO)
negative regulation of low-density lipoprotein receptor activity  (ISO)
negative regulation of neuron death  (ISO)
negative regulation of neuron differentiation  (IDA,IGI)
negative regulation of peptidase activity  (IEA)
negative regulation of pri-miRNA transcription by RNA polymerase II  (ISO)
negative regulation of protein localization to nucleus  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
nervous system development  (IEA)
neuromuscular process controlling balance  (IGI)
neuron apoptotic process  (IGI,ISO)
neuron projection development  (IDA)
neuron projection maintenance  (ISO)
neuron remodeling  (IMP)
Notch signaling pathway  (IEA)
positive regulation of 1-phosphatidylinositol-3-kinase activity  (ISO)
positive regulation of amyloid fibril formation  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process  (ISO)
positive regulation of cellular response to thapsigargin  (ISO)
positive regulation of cellular response to tunicamycin  (ISO)
positive regulation of chemokine production  (ISO)
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process  (ISO)
positive regulation of DNA-binding transcription factor activity  (ISO)
positive regulation of endothelin production  (IGI,ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of excitatory postsynaptic potential  (ISO)
positive regulation of G protein-coupled receptor internalization  (ISO)
positive regulation of G protein-coupled receptor signaling pathway  (ISO)
positive regulation of G2/M transition of mitotic cell cycle  (IMP)
positive regulation of gene expression  (ISO)
positive regulation of glycolytic process  (ISO)
positive regulation of histone acetylation  (ISO)
positive regulation of inflammatory response  (ISO)
positive regulation of interferon-gamma production  (ISO)
positive regulation of interleukin-1 beta production  (ISO)
positive regulation of interleukin-6 production  (ISO)
positive regulation of JNK cascade  (ISO)
positive regulation of long-term synaptic potentiation  (ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of membrane protein ectodomain proteolysis  (ISO)
positive regulation of mitotic cell cycle  (IMP)
positive regulation of monocyte chemotaxis  (ISO)
positive regulation of neuron apoptotic process  (ISO)
positive regulation of neuron death  (ISO)
positive regulation of neuron differentiation  (ISO)
positive regulation of NF-kappaB transcription factor activity  (ISO)
positive regulation of NIK/NF-kappaB signaling  (ISO)
positive regulation of nitric oxide biosynthetic process  (ISO)
positive regulation of oxidative stress-induced neuron death  (ISO)
positive regulation of peptidyl-serine phosphorylation  (ISO)
positive regulation of peptidyl-threonine phosphorylation  (ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of phosphorylation  (ISO)
positive regulation of protein binding  (ISO)
positive regulation of protein import  (ISO)
positive regulation of protein metabolic process  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of protein tyrosine kinase activity  (ISO)
positive regulation of receptor binding  (ISO)
positive regulation of response to endoplasmic reticulum stress  (ISO)
positive regulation of superoxide anion generation  (ISO)
positive regulation of T cell migration  (ISO)
positive regulation of tau-protein kinase activity  (ISO)
positive regulation of transcription by RNA polymerase II  (IDA,IGI,ISO)
positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response  (ISO)
positive regulation of tumor necrosis factor production  (IGI,ISO)
protein homooligomerization  (ISO)
protein phosphorylation  (IMP)
protein tetramerization  (ISO)
protein trimerization  (ISO)
regulation of acetylcholine-gated cation channel activity  (ISO)
regulation of amyloid fibril formation  (ISO)
regulation of amyloid-beta clearance  (ISO)
regulation of calcium ion transmembrane transport via high voltage-gated calcium channel  (ISO)
regulation of dendritic spine maintenance  (ISO)
regulation of epidermal growth factor-activated receptor activity  (IGI)
regulation of gene expression  (IDA,ISO)
regulation of long-term neuronal synaptic plasticity  (ISO)
regulation of multicellular organism growth  (IMP)
regulation of peptidyl-tyrosine phosphorylation  (ISO)
regulation of presynapse assembly  (ISO)
regulation of protein binding  (IGI,IMP)
regulation of response to calcium ion  (ISO)
regulation of spontaneous synaptic transmission  (ISO)
regulation of synapse structure or activity  (IMP)
regulation of toll-like receptor signaling pathway  (ISO)
regulation of transcription by RNA polymerase II  (ISO)
regulation of translation  (IDA)
response to auditory stimulus  (ISO)
response to interleukin-1  (ISO)
response to lead ion  (ISO)
response to oxidative stress  (IGI)
response to radiation  (ISO)
response to yeast  (ISO)
smooth endoplasmic reticulum calcium ion homeostasis  (IGI)
suckling behavior  (IGI)
synapse organization  (ISO)
synaptic assembly at neuromuscular junction  (IGI)
visual learning  (IMP)

Cellular Component
amyloid-beta complex  (ISO)
apical part of cell  (IDA)
astrocyte projection  (ISO)
axon  (IDA,ISO)
cell body  (ISO)
cell projection  (IEA)
cell surface  (IDA,ISO)
cell-cell junction  (IDA)
ciliary rootlet  (IDA)
clathrin-coated pit  (IEA)
COPII-coated ER to Golgi transport vesicle  (IDA)
cytoplasm  (IDA,ISO)
cytoplasmic vesicle  (IDA)
dendrite  (ISO)
dendrite membrane  (ISO)
early endosome  (IDA,ISO)
endosome  (ISO)
endosome to plasma membrane transport vesicle  (ISO)
extracellular region  (IEA)
extracellular space  (ISO)
extrinsic component of external side of plasma membrane  (ISO)
Golgi apparatus  (IDA,ISO)
Golgi-associated vesicle  (IDA)
growth cone  (ISO)
growth cone filopodium  (ISO)
growth cone lamellipodium  (ISO)
high-density lipoprotein particle  (ISO)
integral component of membrane  (IDA)
intermediate-density lipoprotein particle  (ISO)
lipoprotein particle  (ISO)
low-density lipoprotein particle  (ISO)
lysosome  (ISO)
main axon  (ISO)
membrane  (IDA,ISO,TAS)
membrane raft  (ISO)
mitochondrion  (ISO)
neuromuscular junction  (IDA)
neuron projection  (IDA,ISO)
nuclear envelope lumen  (ISO)
nucleus  (ISO)
perinuclear region of cytoplasm  (IDA,ISO)
plasma membrane  (IDA,ISO)
postsynapse  (ISO)
presynapse  (ISO)
presynaptic active zone  (IDA,IEP)
protein-containing complex  (ISO)
receptor complex  (ISO)
recycling endosome  (IDA)
rough endoplasmic reticulum  (ISO)
spindle midzone  (IDA)
synaptic membrane  (ISO)
synaptic vesicle  (IDA,ISO)
very-low-density lipoprotein particle  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal active avoidance behavior  (IAGP)
abnormal brain commissure morphology  (IAGP)
abnormal brain morphology  (IAGP)
abnormal cell physiology  (IAGP)
abnormal cholinergic neuron morphology  (IAGP)
abnormal circadian behavior  (IAGP)
abnormal cued conditioning behavior  (IAGP)
abnormal emotion/affect behavior  (IAGP)
abnormal excitatory postsynaptic currents  (IAGP)
abnormal fear/anxiety-related behavior  (IAGP)
abnormal learning/memory/conditioning  (IAGP)
abnormal locomotor activation  (IAGP)
abnormal locomotor behavior  (IAGP)
abnormal long term object recognition memory  (IAGP)
abnormal long term potentiation  (IAGP)
abnormal microglial cell morphology  (IAGP)
abnormal miniature endplate potential  (IAGP)
abnormal motor capabilities/coordination/movement  (IAGP)
abnormal neuromuscular synapse morphology  (IAGP)
abnormal neuron differentiation  (IAGP)
abnormal neuron morphology  (IAGP)
abnormal spatial learning  (IAGP)
abnormal spatial reference memory  (IAGP)
abnormal spatial working memory  (IAGP)
abnormal stratification in cerebral cortex  (IAGP)
abnormal synapse morphology  (IAGP)
abnormal telencephalon morphology  (IAGP)
absent corpus callosum  (IAGP)
absent gastric milk in neonates  (IAGP)
amyloid beta deposits  (IAGP)
amyloidosis  (IAGP)
astrocytosis  (IAGP)
ataxia  (IAGP)
centrally nucleated skeletal muscle fibers  (IAGP)
CNS inflammation  (IAGP)
decreased anterior commissure size  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased brain size  (IAGP)
decreased brain weight  (IAGP)
decreased circulating bilirubin level  (IEA)
decreased corpus callosum size  (IAGP)
decreased exploration in new environment  (IAGP)
decreased grip strength  (IAGP)
decreased hippocampal commissure size  (IAGP)
decreased startle reflex  (IEA)
demyelination  (IAGP)
enhanced contextual conditioning behavior  (IAGP)
gliosis  (IAGP)
head tilt  (IAGP)
hematoma  (IAGP)
hyperactivity  (IAGP)
hypoactivity  (IAGP)
impaired coordination  (IAGP)
impaired passive avoidance behavior  (IAGP)
impaired righting response  (IAGP)
impaired swimming  (IAGP)
increased anxiety-related response  (IAGP)
increased astrocyte number  (IAGP)
increased blood urea nitrogen level  (IEA)
increased brain cholesterol level  (IAGP)
increased circulating corticosterone level  (IAGP)
increased fear-related response  (IAGP)
increased mean corpuscular hemoglobin  (IEA)
increased neuron apoptosis  (IAGP)
increased or absent threshold for auditory brainstem response  (IEA)
increased susceptibility to induced thrombosis  (IAGP)
increased thigmotaxis  (IAGP)
increased variability of skeletal muscle fiber size  (IAGP)
intracerebral hemorrhage  (IAGP)
microgliosis  (IAGP)
muscle degeneration  (IAGP)
myositis  (IAGP)
no abnormal phenotype detected  (IAGP)
pallor  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
premature death  (IAGP)
preweaning lethality, incomplete penetrance  (IAGP)
Purkinje cell degeneration  (IAGP)
reduced fertility  (IAGP)
reduced long term potentiation  (IAGP)
short tibia  (IEA)
small cerebellum  (IAGP)
spinning  (IAGP)
tau protein deposits  (IAGP)
weakness  (IAGP)
weight loss  (IAGP)

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