APP (amyloid beta precursor protein) - Rat Genome Database

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Gene: APP (amyloid beta precursor protein) Pan paniscus
Analyze
Symbol: APP
Name: amyloid beta precursor protein
RGD ID: 11944783
Description: ENCODES a protein that exhibits acetylcholine receptor binding (ortholog); apolipoprotein binding (ortholog); chemoattractant activity (ortholog); INVOLVED IN adenylate cyclase-activating G protein-coupled receptor signaling pathway (ortholog); adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway (ortholog); adult locomotory behavior (ortholog); PARTICIPATES IN glypican signaling pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); Alzheimer's disease 1 (ortholog); Alzheimer's Disease, Early-Onset, with Cerebral Amyloid Angiopathy (ortholog); FOUND IN amyloid-beta complex (ortholog); astrocyte projection (ortholog); axon (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: amyloid beta A4 protein-like; LOC100970102; LOC100971121
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22222,074,135 - 22,358,605 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12116,933,539 - 17,218,837 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02112,324,455 - 12,608,594 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12125,683,236 - 25,995,262 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2125,684,355 - 25,995,072 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenylate cyclase-activating G protein-coupled receptor signaling pathway  (ISO)
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway  (ISO)
adult locomotory behavior  (IEA,ISO)
amyloid fibril formation  (IEA)
antibacterial humoral response  (ISO)
antifungal humoral response  (ISO)
antimicrobial humoral immune response mediated by antimicrobial peptide  (ISO)
apoptotic process  (IEA)
associative learning  (ISO)
astrocyte activation  (IEA)
astrocyte activation involved in immune response  (IEA)
axo-dendritic transport  (IEA,ISO)
axon midline choice point recognition  (IEA,ISO)
axonogenesis  (IEA,ISO)
calcium-mediated signaling  (ISO)
cellular response to amyloid-beta  (IEA)
cellular response to cAMP  (ISO)
cellular response to copper ion  (ISO)
cellular response to manganese ion  (ISO)
cellular response to nerve growth factor stimulus  (ISO)
cellular response to norepinephrine stimulus  (ISO)
central nervous system development  (IEA)
chemical synaptic transmission  (ISO)
cholesterol metabolic process  (IEA,ISO)
cognition  (IEA,ISO)
collateral sprouting in absence of injury  (IEA,ISO)
cytosolic mRNA polyadenylation  (IEA,ISO)
defense response to Gram-negative bacterium  (ISO)
defense response to Gram-positive bacterium  (ISO)
dendrite development  (IEA,ISO)
endocytosis  (IEA,ISO)
extracellular matrix organization  (IEA,ISO)
forebrain development  (IEA,ISO)
G protein-coupled receptor signaling pathway  (ISO)
G2/M transition of mitotic cell cycle  (IEA,ISO)
gene expression  (IEA,ISO)
innate immune response  (ISO)
intracellular copper ion homeostasis  (IEA,ISO)
ionotropic glutamate receptor signaling pathway  (IEA,ISO)
learning  (IEA)
learning or memory  (IEA)
locomotory behavior  (IEA,ISO)
low-density lipoprotein particle mediated signaling  (ISO)
mating behavior  (IEA,ISO)
memory  (ISO)
microglia development  (IEA)
microglial cell activation  (IEA)
mitotic cell cycle  (IEA,ISO)
modulation of excitatory postsynaptic potential  (IEA)
negative regulation of blood circulation  (ISO)
negative regulation of canonical Wnt signaling pathway  (ISO)
negative regulation of cell population proliferation  (IEA)
negative regulation of gene expression  (IEA)
negative regulation of long-term synaptic potentiation  (IEA)
negative regulation of miRNA transcription  (ISO)
negative regulation of neuron differentiation  (IEA,ISO)
negative regulation of peptidase activity  (IEA)
negative regulation of presynapse assembly  (IEA,ISO)
negative regulation of protein localization to nucleus  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
neuromuscular process controlling balance  (IEA,ISO)
neuron apoptotic process  (IEA,ISO)
neuron cellular homeostasis  (IEA,ISO)
neuron differentiation  (IEA,ISO)
neuron projection development  (IEA,ISO)
neuron projection maintenance  (IEA)
neuron remodeling  (IEA,ISO)
Notch signaling pathway  (IEA)
phospholipase D-activating G protein-coupled receptor signaling pathway  (ISO)
positive regulation of amyloid fibril formation  (IEA)
positive regulation of amyloid precursor protein catabolic process  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of calcium-mediated signaling  (IEA)
positive regulation of cAMP/PKA signal transduction  (ISO)
positive regulation of chemokine production  (IEA)
positive regulation of endothelin production  (ISO)
positive regulation of ERK1 and ERK2 cascade  (IEA)
positive regulation of excitatory postsynaptic potential  (ISO)
positive regulation of extrinsic apoptotic signaling pathway  (ISO)
positive regulation of G protein-coupled receptor internalization  (ISO)
positive regulation of G protein-coupled receptor signaling pathway  (ISO)
positive regulation of G2/M transition of mitotic cell cycle  (IEA,ISO)
positive regulation of gene expression  (IEA)
positive regulation of gene expression, epigenetic  (ISO)
positive regulation of glycolytic process  (IEA)
positive regulation of inflammatory response  (IEA)
positive regulation of interleukin-1 beta production  (IEA)
positive regulation of interleukin-6 production  (IEA)
positive regulation of JNK cascade  (IEA)
positive regulation of long-term synaptic potentiation  (IEA)
positive regulation of MAPK cascade  (ISO)
positive regulation of membrane protein ectodomain proteolysis  (ISO)
positive regulation of mitotic cell cycle  (IEA,ISO)
positive regulation of monocyte chemotaxis  (ISO)
positive regulation of neuron apoptotic process  (ISO)
positive regulation of neuron differentiation  (ISO)
positive regulation of nitric oxide biosynthetic process  (ISO)
positive regulation of non-canonical NF-kappaB signal transduction  (IEA)
positive regulation of peptidyl-serine phosphorylation  (IEA)
positive regulation of peptidyl-threonine phosphorylation  (IEA)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of protein import  (ISO)
positive regulation of protein metabolic process  (IEA)
positive regulation of protein phosphorylation  (IEA)
positive regulation of response to endoplasmic reticulum stress  (ISO)
positive regulation of superoxide anion generation  (ISO)
positive regulation of T cell migration  (IEA)
positive regulation of Toll signaling pathway  (ISO)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
positive regulation of tumor necrosis factor production  (IEA)
positive regulation of type II interferon production  (ISO)
protein homooligomerization  (ISO)
protein phosphorylation  (ISO)
protein tetramerization  (ISO)
protein trimerization  (ISO)
regulation of amyloid fibril formation  (ISO)
regulation of amyloid-beta clearance  (ISO)
regulation of calcium ion transmembrane transport via high voltage-gated calcium channel  (ISO)
regulation of dendritic spine maintenance  (ISO)
regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway  (ISO)
regulation of epidermal growth factor-activated receptor activity  (ISO)
regulation of gene expression  (IEA,ISO)
regulation of long-term neuronal synaptic plasticity  (IEA)
regulation of multicellular organism growth  (IEA,ISO)
regulation of neurotransmitter uptake  (ISO)
regulation of peptidyl-tyrosine phosphorylation  (IEA)
regulation of presynapse assembly  (IEA)
regulation of response to calcium ion  (ISO)
regulation of spontaneous synaptic transmission  (IEA)
regulation of synapse structure or activity  (IEA,ISO)
regulation of toll-like receptor signaling pathway  (ISO)
regulation of transcription by RNA polymerase II  (ISO)
regulation of translation  (IEA,ISO)
response to auditory stimulus  (ISO)
response to interleukin-1  (ISO)
response to lead ion  (ISO)
response to oxidative stress  (IEA,ISO)
response to yeast  (ISO)
smooth endoplasmic reticulum calcium ion homeostasis  (IEA,ISO)
suckling behavior  (IEA,ISO)
synapse organization  (IEA)
synaptic assembly at neuromuscular junction  (IEA,ISO)
visual learning  (IEA,ISO)

Cellular Component
amyloid-beta complex  (ISO)
apical part of cell  (IEA)
astrocyte projection  (ISO)
axon  (IEA,ISO)
cell body  (ISO)
cell projection  (IEA)
cell surface  (IEA,ISO)
cell-cell junction  (IEA)
ciliary rootlet  (IEA)
clathrin-coated pit  (IEA)
COPII-coated ER to Golgi transport vesicle  (IEA)
cytoplasm  (IEA)
cytoplasmic vesicle  (IEA)
dendrite  (IEA,ISO)
dendrite membrane  (ISO)
dendritic shaft  (IEA)
dendritic spine  (IEA)
early endosome  (IEA)
endomembrane system  (IEA)
endoplasmic reticulum  (IEA)
endosome  (IEA)
endosome to plasma membrane transport vesicle  (ISO)
external side of plasma membrane  (ISO)
extracellular region  (IEA)
extracellular space  (IEA,ISO)
Golgi apparatus  (IEA)
Golgi-associated vesicle  (IEA)
growth cone  (IEA,ISO)
growth cone filopodium  (ISO)
growth cone lamellipodium  (ISO)
high-density lipoprotein particle  (ISO)
intermediate-density lipoprotein particle  (ISO)
intracellular vesicle  (IEA,ISO)
lipoprotein particle  (ISO)
low-density lipoprotein particle  (ISO)
lysosome  (ISO)
main axon  (ISO)
membrane  (IEA)
membrane raft  (IEA)
mitochondrion  (ISO)
neuromuscular junction  (IEA)
neuron projection  (IEA)
neuronal dense core vesicle  (ISO)
nuclear envelope lumen  (IEA)
nucleus  (IEA)
perikaryon  (IEA)
perinuclear region of cytoplasm  (IEA)
plasma membrane  (IEA)
postsynapse  (ISO)
presynapse  (ISO)
presynaptic active zone  (IEA,ISO)
protein-containing complex  (ISO)
receptor complex  (IEA)
recycling endosome  (IEA)
smooth endoplasmic reticulum  (IEA)
spindle midzone  (IEA)
synapse  (IEA)
synaptic membrane  (ISO)
synaptic vesicle  (IEA,ISO)
very-low-density lipoprotein particle  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
APP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22222,074,135 - 22,358,605 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12116,933,539 - 17,218,837 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02112,324,455 - 12,608,594 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12125,683,236 - 25,995,262 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2125,684,355 - 25,995,072 (-)Ensemblpanpan1.1panPan2
APP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382125,880,550 - 26,171,128 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2125,880,535 - 26,171,128 (-)EnsemblGRCh38hg38GRCh38
GRCh372127,252,861 - 27,543,446 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362126,174,732 - 26,465,003 (-)NCBINCBI36Build 36hg18NCBI36
Build 342126,174,732 - 26,465,003NCBI
Celera2112,436,275 - 12,726,567 (-)NCBICelera
Cytogenetic Map21q21.3NCBI
HuRef2112,656,350 - 12,947,965 (-)NCBIHuRef
CHM1_12126,813,502 - 27,104,969 (-)NCBICHM1_1
T2T-CHM13v2.02124,238,622 - 24,529,258 (-)NCBIT2T-CHM13v2.0
App
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391684,751,236 - 84,972,187 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1684,746,573 - 84,970,654 (-)EnsemblGRCm39 Ensembl
GRCm381684,952,666 - 85,175,255 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1684,949,685 - 85,173,766 (-)EnsemblGRCm38mm10GRCm38
MGSCv371684,954,688 - 85,173,948 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361684,837,873 - 85,057,149 (-)NCBIMGSCv36mm8
Celera1685,161,866 - 85,382,753 (-)NCBICelera
Cytogenetic Map16C3.3NCBI
cM Map1646.92NCBI
App
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81137,506,207 - 37,724,351 (-)NCBIGRCr8
mRatBN7.21124,019,774 - 24,236,584 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1124,019,778 - 24,236,561 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1132,713,957 - 32,929,750 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01125,414,338 - 25,630,128 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01124,603,106 - 24,818,898 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01124,425,013 - 24,641,872 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1124,425,005 - 24,641,858 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01128,048,897 - 28,265,250 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41124,457,855 - 24,693,851 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11124,457,854 - 24,693,851 (-)NCBI
Celera1123,853,696 - 24,069,048 (-)NCBICelera
RH 3.4 Map1194.7RGD
Cytogenetic Map11q11NCBI
App
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540725,722,849 - 25,974,268 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540725,725,259 - 25,973,582 (-)NCBIChiLan1.0ChiLan1.0
APP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13121,351,207 - 21,614,466 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3121,351,207 - 21,614,337 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3121,345,590 - 21,608,332 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03121,405,966 - 21,669,000 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3121,405,966 - 21,668,874 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13121,422,808 - 21,685,736 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03121,425,054 - 21,689,657 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03121,899,466 - 22,164,885 (-)NCBIUU_Cfam_GSD_1.0
App
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440497121,893,758 - 22,131,543 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366401,550,167 - 1,787,286 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366401,549,977 - 1,787,436 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
APP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13189,435,094 - 189,716,056 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113189,434,854 - 189,716,120 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213199,290,846 - 199,568,764 (-)NCBISscrofa10.2Sscrofa10.2susScr3
APP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1266,037,224 - 66,320,860 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl266,037,261 - 66,321,306 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660718,700,007 - 8,984,223 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
App
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474513,902,577 - 14,159,372 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474513,904,912 - 14,159,374 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Sequence


Ensembl Acc Id: ENSPPAT00000011926   ⟹   ENSPPAP00000002473
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2125,684,355 - 25,995,072 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000011930   ⟹   ENSPPAP00000002474
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2125,684,355 - 25,995,072 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000011949   ⟹   ENSPPAP00000002479
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2125,684,355 - 25,995,072 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000011950   ⟹   ENSPPAP00000002480
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2125,684,355 - 25,995,072 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000011964   ⟹   ENSPPAP00000002483
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2125,684,355 - 25,995,072 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000011969   ⟹   ENSPPAP00000002485
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2125,684,355 - 25,964,680 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000012046   ⟹   ENSPPAP00000002501
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2125,684,355 - 25,941,154 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000012131   ⟹   ENSPPAP00000002531
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2125,684,355 - 25,939,165 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000012136   ⟹   ENSPPAP00000002536
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2125,684,355 - 25,936,727 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000012139   ⟹   ENSPPAP00000002539
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2125,684,355 - 25,936,727 (-)Ensembl
RefSeq Acc Id: XM_008969774   ⟹   XP_008968022
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22222,074,135 - 22,358,595 (-)NCBI
NHGRI_mPanPan12116,933,539 - 17,218,772 (-)NCBI
Mhudiblu_PPA_v02112,324,485 - 12,608,594 (-)NCBI
PanPan1.12125,683,236 - 25,995,262 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008969775   ⟹   XP_008968023
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22222,074,135 - 22,358,566 (-)NCBI
NHGRI_mPanPan12116,933,539 - 17,218,781 (-)NCBI
Mhudiblu_PPA_v02112,324,455 - 12,608,594 (-)NCBI
PanPan1.12125,683,236 - 25,995,262 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008969776   ⟹   XP_008968024
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22222,074,135 - 22,358,605 (-)NCBI
NHGRI_mPanPan12116,933,539 - 17,218,837 (-)NCBI
Mhudiblu_PPA_v02112,324,461 - 12,608,594 (-)NCBI
PanPan1.12125,683,236 - 25,995,262 (-)NCBI
Sequence:
RefSeq Acc Id: XM_055105200   ⟹   XP_054961175
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22222,074,135 - 22,358,512 (-)NCBI
NHGRI_mPanPan12116,933,539 - 17,167,461 (-)NCBI
RefSeq Acc Id: XM_055105201   ⟹   XP_054961176
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22222,074,135 - 22,358,511 (-)NCBI
NHGRI_mPanPan12116,933,539 - 17,167,461 (-)NCBI
RefSeq Acc Id: XM_055105202   ⟹   XP_054961177
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22222,074,135 - 22,358,510 (-)NCBI
NHGRI_mPanPan12116,933,539 - 17,167,461 (-)NCBI
RefSeq Acc Id: XP_008968023   ⟸   XM_008969775
- Peptide Label: isoform X5
- UniProtKB: A0A2R8ZBP8 (UniProtKB/TrEMBL),   A0A2R8ZIG8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008968022   ⟸   XM_008969774
- Peptide Label: isoform X4
- UniProtKB: A0A2R8ZBU5 (UniProtKB/TrEMBL),   A0A2R8ZFM4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008968024   ⟸   XM_008969776
- Peptide Label: isoform X6
- UniProtKB: A0A2R8ZIN4 (UniProtKB/TrEMBL),   A0A2R8ZFN4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSPPAP00000002480   ⟸   ENSPPAT00000011950
Ensembl Acc Id: ENSPPAP00000002479   ⟸   ENSPPAT00000011949
Ensembl Acc Id: ENSPPAP00000002485   ⟸   ENSPPAT00000011969
Ensembl Acc Id: ENSPPAP00000002483   ⟸   ENSPPAT00000011964
Ensembl Acc Id: ENSPPAP00000002474   ⟸   ENSPPAT00000011930
Ensembl Acc Id: ENSPPAP00000002473   ⟸   ENSPPAT00000011926
Ensembl Acc Id: ENSPPAP00000002501   ⟸   ENSPPAT00000012046
Ensembl Acc Id: ENSPPAP00000002539   ⟸   ENSPPAT00000012139
Ensembl Acc Id: ENSPPAP00000002536   ⟸   ENSPPAT00000012136
Ensembl Acc Id: ENSPPAP00000002531   ⟸   ENSPPAT00000012131
RefSeq Acc Id: XP_054961177   ⟸   XM_055105202
- Peptide Label: isoform X3
- UniProtKB: A0A2R8ZIN4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054961176   ⟸   XM_055105201
- Peptide Label: isoform X2
- UniProtKB: A0A2R8ZBP8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054961175   ⟸   XM_055105200
- Peptide Label: isoform X1
- UniProtKB: A0A2R8ZBU5 (UniProtKB/TrEMBL)
Protein Domains
BPTI/Kunitz inhibitor   E1   E2


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000002732 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000011926.1 UniProtKB/TrEMBL
  ENSPPAT00000011930.1 UniProtKB/TrEMBL
  ENSPPAT00000011949.1 UniProtKB/TrEMBL
  ENSPPAT00000011950.1 UniProtKB/TrEMBL
  ENSPPAT00000011964.1 UniProtKB/TrEMBL
  ENSPPAT00000011969.1 UniProtKB/TrEMBL
  ENSPPAT00000012046.1 UniProtKB/TrEMBL
  ENSPPAT00000012131.1 UniProtKB/TrEMBL
  ENSPPAT00000012136.1 UniProtKB/TrEMBL
  ENSPPAT00000012139.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.120.770 UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/TrEMBL
  3.30.1490.140 UniProtKB/TrEMBL
  3.90.570.10 UniProtKB/TrEMBL
  4.10.230.10 UniProtKB/TrEMBL
  4.10.410.10 UniProtKB/TrEMBL
InterPro Amyloid_Cu-bd_sf UniProtKB/TrEMBL
  Amyloid_glyco UniProtKB/TrEMBL
  Amyloid_glyco_Abeta UniProtKB/TrEMBL
  Amyloid_glyco_Abeta_sf UniProtKB/TrEMBL
  Amyloid_glyco_Cu-bd UniProtKB/TrEMBL
  Amyloid_glyco_E2_domain UniProtKB/TrEMBL
  Amyloid_glyco_extra UniProtKB/TrEMBL
  Amyloid_glyco_heparin-bd UniProtKB/TrEMBL
  Amyloid_glyco_heparin-bd_sf UniProtKB/TrEMBL
  Amyloid_glyco_intracell_CS UniProtKB/TrEMBL
  APP_amyloid_C UniProtKB/TrEMBL
  APP_CUBD_CS UniProtKB/TrEMBL
  E2_sf UniProtKB/TrEMBL
  Kunitz_BPTI UniProtKB/TrEMBL
  Kunitz_BPTI_sf UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/TrEMBL
  Prtase_inh_Kunz-CS UniProtKB/TrEMBL
NCBI Gene LOC100971121 ENTREZGENE
PANTHER AMYLOID-BETA A4 PROTEIN UniProtKB/TrEMBL
  PTHR23103 UniProtKB/TrEMBL
  PTHR23103:SF7 UniProtKB/TrEMBL
Pfam APP_amyloid UniProtKB/TrEMBL
  APP_Cu_bd UniProtKB/TrEMBL
  APP_E2 UniProtKB/TrEMBL
  APP_N UniProtKB/TrEMBL
  Beta-APP UniProtKB/TrEMBL
  Kunitz_BPTI UniProtKB/TrEMBL
PRINTS AMYLOIDA4 UniProtKB/TrEMBL
  BASICPTASE UniProtKB/TrEMBL
  BETAAMYLOID UniProtKB/TrEMBL
PROSITE APP_CUBD UniProtKB/TrEMBL
  APP_E1 UniProtKB/TrEMBL
  APP_E2 UniProtKB/TrEMBL
  APP_INTRA UniProtKB/TrEMBL
  BPTI_KUNITZ_1 UniProtKB/TrEMBL
  BPTI_KUNITZ_2 UniProtKB/TrEMBL
SMART A4_EXTRA UniProtKB/TrEMBL
  SM00131 UniProtKB/TrEMBL
Superfamily-SCOP SSF109843 UniProtKB/TrEMBL
  SSF56491 UniProtKB/TrEMBL
  SSF57362 UniProtKB/TrEMBL
  SSF89811 UniProtKB/TrEMBL
UniProt A0A2R8ZBP3_PANPA UniProtKB/TrEMBL
  A0A2R8ZBP8 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R8ZBQ3_PANPA UniProtKB/TrEMBL
  A0A2R8ZBT8_PANPA UniProtKB/TrEMBL
  A0A2R8ZBU5 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R8ZFM4 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R8ZFN4 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R8ZIG3_PANPA UniProtKB/TrEMBL
  A0A2R8ZIG8 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R8ZIN4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-05-08 APP  amyloid beta precursor protein  LOC100970102  amyloid beta A4 protein-like  Data merged from RGD:11791799 737654 PROVISIONAL
2018-05-08 APP  amyloid beta precursor protein  LOC100971121  amyloid beta A4 protein  Symbol and/or name change 5135510 APPROVED