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Gene: Notch2 (notch receptor 2) Rattus norvegicus
Symbol: Notch2
Name: notch receptor 2
Description: Predicted to have NF-kappaB binding activity and enzyme binding activity. Involved in cell fate determination and tissue regeneration. Predicted to localize to several cellular components, including cell surface; cilium; and nucleoplasm. Human ortholog(s) of this gene implicated in Alagille syndrome and Hajdu-Cheney syndrome. Orthologous to human NOTCH2 (notch receptor 2); PARTICIPATES IN altered Notch signaling pathway; Notch signaling pathway; Notch signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 3-methylcholanthrene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: neurogenic locus notch homolog protein 2; notch 2; notch gene homolog 2; notch gene homolog 2 (Drosophila); Notch homolog 2; Notch homolog 2 (Drosophila)
Homo sapiens (human) : NOTCH2 (notch receptor 2)  HGNC  Alliance
Mus musculus (house mouse) : Notch2 (notch 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Notch2 (notch receptor 2)
Pan paniscus (bonobo/pygmy chimpanzee) : NOTCH2 (notch receptor 2)
Canis lupus familiaris (dog) : NOTCH2 (notch receptor 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Notch2 (notch receptor 2)
Sus scrofa (pig) : NOTCH2 (notch receptor 2)
Chlorocebus sabaeus (African green monkey) : NOTCH2 (notch receptor 2)
Heterocephalus glaber (naked mole-rat) : Notch2 (notch receptor 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.02200,187,184 - 200,320,403 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2200,187,179 - 200,320,215 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02219,662,511 - 219,793,306 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.02207,597,473 - 207,599,560 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42192,839,350 - 192,986,589 (+)NCBIRGSC3.4rn4RGSC3.4
Celera2178,101,416 - 178,234,556 (+)NCBICelera
Cytogenetic Map2q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Notch2
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3188
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-07-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.