LOC101959175 (amyloid beta precursor protein) - Rat Genome Database

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Gene: LOC101959175 (amyloid beta precursor protein) Ictidomys tridecemlineatus
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Symbol: LOC101959175
Name: amyloid beta precursor protein
RGD ID: 12612074
Description: ENCODES a protein that exhibits acetylcholine receptor binding (ortholog); apolipoprotein binding (ortholog); chaperone binding (ortholog); INVOLVED IN adenylate cyclase-activating G protein-coupled receptor signaling pathway (ortholog); adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway (ortholog); adult locomotory behavior (ortholog); PARTICIPATES IN glypican signaling pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); Alzheimer's disease 1 (ortholog); Alzheimer's Disease, Early-Onset, with Cerebral Amyloid Angiopathy (ortholog); FOUND IN amyloid-beta complex (ortholog); apical part of cell (ortholog); astrocyte projection (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: App
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440497121,893,758 - 22,131,543 (-)NCBI
SpeTri2.0NW_0049366401,549,977 - 1,787,436 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenylate cyclase-activating G protein-coupled receptor signaling pathway  (ISO)
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway  (ISO)
adult locomotory behavior  (ISO)
amyloid fibril formation  (ISO)
antibacterial humoral response  (ISO)
antifungal humoral response  (ISO)
antimicrobial humoral immune response mediated by antimicrobial peptide  (ISO)
associative learning  (ISO)
astrocyte activation  (ISO)
astrocyte activation involved in immune response  (ISO)
axo-dendritic transport  (ISO)
axon midline choice point recognition  (ISO)
axonogenesis  (ISO)
calcium-mediated signaling  (ISO)
cellular copper ion homeostasis  (ISO)
cellular response to amyloid-beta  (ISO)
cellular response to cAMP  (ISO)
cellular response to copper ion  (ISO)
cellular response to manganese ion  (ISO)
cellular response to nerve growth factor stimulus  (ISO)
cellular response to norepinephrine stimulus  (ISO)
chemical synaptic transmission  (ISO)
cholesterol metabolic process  (ISO)
cognition  (ISO)
collateral sprouting in absence of injury  (ISO)
defense response to Gram-negative bacterium  (ISO)
defense response to Gram-positive bacterium  (ISO)
dendrite development  (ISO)
endocytosis  (ISO)
extracellular matrix organization  (ISO)
forebrain development  (ISO)
G protein-coupled receptor signaling pathway  (ISO)
innate immune response  (ISO)
ionotropic glutamate receptor signaling pathway  (ISO)
learning  (ISO)
learning or memory  (ISO)
locomotory behavior  (ISO)
mating behavior  (ISO)
memory  (ISO)
microglia development  (ISO)
microglial cell activation  (ISO)
modulation of age-related behavioral decline  (ISO)
modulation of excitatory postsynaptic potential  (ISO)
mRNA polyadenylation  (ISO)
negative regulation of blood circulation  (ISO)
negative regulation of canonical Wnt signaling pathway  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of dendritic spine maintenance  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of long-term synaptic potentiation  (ISO)
negative regulation of low-density lipoprotein receptor activity  (ISO)
negative regulation of neuron death  (ISO)
negative regulation of neuron differentiation  (ISO)
negative regulation of pri-miRNA transcription by RNA polymerase II  (ISO)
negative regulation of protein localization to nucleus  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
negative regulation of Wnt signaling pathway  (ISO)
neuromuscular process controlling balance  (ISO)
neuron apoptotic process  (ISO)
neuron projection development  (ISO)
neuron projection maintenance  (ISO)
neuron remodeling  (ISO)
positive regulation of 1-phosphatidylinositol-3-kinase activity  (ISO)
positive regulation of amyloid fibril formation  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process  (ISO)
positive regulation of cellular response to thapsigargin  (ISO)
positive regulation of cellular response to tunicamycin  (ISO)
positive regulation of chemokine production  (ISO)
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process  (ISO)
positive regulation of DNA-binding transcription factor activity  (ISO)
positive regulation of endothelin production  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of excitatory postsynaptic potential  (ISO)
positive regulation of G protein-coupled receptor internalization  (ISO)
positive regulation of G protein-coupled receptor signaling pathway  (ISO)
positive regulation of G2/M transition of mitotic cell cycle  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of glycolytic process  (ISO)
positive regulation of histone acetylation  (ISO)
positive regulation of inflammatory response  (ISO)
positive regulation of interferon-gamma production  (ISO)
positive regulation of interleukin-1 beta production  (ISO)
positive regulation of interleukin-6 production  (ISO)
positive regulation of JNK cascade  (ISO)
positive regulation of long-term synaptic depression  (ISO)
positive regulation of long-term synaptic potentiation  (ISO)
positive regulation of MAP kinase activity  (ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of membrane protein ectodomain proteolysis  (ISO)
positive regulation of mitotic cell cycle  (ISO)
positive regulation of monocyte chemotaxis  (ISO)
positive regulation of neuron apoptotic process  (ISO)
positive regulation of neuron death  (ISO)
positive regulation of neuron differentiation  (ISO)
positive regulation of NF-kappaB transcription factor activity  (ISO)
positive regulation of NIK/NF-kappaB signaling  (ISO)
positive regulation of nitric oxide biosynthetic process  (ISO)
positive regulation of oxidative stress-induced neuron death  (ISO)
positive regulation of peptidyl-serine phosphorylation  (ISO)
positive regulation of peptidyl-threonine phosphorylation  (ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of phosphorylation  (ISO)
positive regulation of protein binding  (ISO)
positive regulation of protein import  (ISO)
positive regulation of protein metabolic process  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of protein tyrosine kinase activity  (ISO)
positive regulation of receptor binding  (ISO)
positive regulation of response to endoplasmic reticulum stress  (ISO)
positive regulation of superoxide anion generation  (ISO)
positive regulation of T cell migration  (ISO)
positive regulation of tau-protein kinase activity  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response  (ISO)
positive regulation of tumor necrosis factor production  (ISO)
protein homooligomerization  (ISO)
protein phosphorylation  (ISO)
protein tetramerization  (ISO)
protein trimerization  (ISO)
regulation of acetylcholine-gated cation channel activity  (ISO)
regulation of amyloid fibril formation  (ISO)
regulation of amyloid-beta clearance  (ISO)
regulation of calcium ion transmembrane transport via high voltage-gated calcium channel  (ISO)
regulation of dendritic spine maintenance  (ISO)
regulation of epidermal growth factor-activated receptor activity  (ISO)
regulation of gene expression  (ISO)
regulation of long-term neuronal synaptic plasticity  (ISO)
regulation of MAPK cascade  (ISO)
regulation of multicellular organism growth  (ISO)
regulation of peptidyl-tyrosine phosphorylation  (ISO)
regulation of presynapse assembly  (ISO)
regulation of protein binding  (ISO)
regulation of response to calcium ion  (ISO)
regulation of signaling receptor activity  (ISO)
regulation of spontaneous synaptic transmission  (ISO)
regulation of synapse structure or activity  (ISO)
regulation of toll-like receptor signaling pathway  (ISO)
regulation of transcription by RNA polymerase II  (ISO)
regulation of translation  (ISO)
response to auditory stimulus  (ISO)
response to interleukin-1  (ISO)
response to lead ion  (ISO)
response to oxidative stress  (ISO)
response to radiation  (ISO)
response to yeast  (ISO)
smooth endoplasmic reticulum calcium ion homeostasis  (ISO)
suckling behavior  (ISO)
synapse organization  (ISO)
synaptic assembly at neuromuscular junction  (ISO)
visual learning  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
LOC101959175
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440497121,893,758 - 22,131,543 (-)NCBI
SpeTri2.0NW_0049366401,549,977 - 1,787,436 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
APP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2125,880,550 - 26,171,128 (-)EnsemblGRCh38hg38GRCh38
GRCh382125,880,550 - 26,171,128 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372127,252,861 - 27,543,446 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362126,174,732 - 26,465,003 (-)NCBINCBI36hg18NCBI36
Build 342126,174,732 - 26,465,003NCBI
Celera2112,436,275 - 12,726,567 (-)NCBI
Cytogenetic Map21q21.3NCBI
HuRef2112,656,350 - 12,947,965 (-)NCBIHuRef
CHM1_12126,813,502 - 27,104,969 (-)NCBICHM1_1
App
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391684,751,236 - 84,972,187 (-)NCBIGRCm39mm39
GRCm39 Ensembl1684,746,573 - 84,970,654 (-)Ensembl
GRCm381684,952,666 - 85,175,255 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1684,949,685 - 85,173,766 (-)EnsemblGRCm38mm10GRCm38
MGSCv371684,954,688 - 85,173,948 (-)NCBIGRCm37mm9NCBIm37
MGSCv361684,837,873 - 85,057,149 (-)NCBImm8
Celera1685,161,866 - 85,382,753 (-)NCBICelera
Cytogenetic Map16C3.3NCBI
cM Map1646.92NCBI
App
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21124,019,774 - 24,236,584 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1124,019,778 - 24,236,561 (-)Ensembl
Rnor_6.01124,425,013 - 24,641,872 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1124,425,005 - 24,641,858 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01128,048,897 - 28,265,250 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41124,457,855 - 24,693,851 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11124,457,854 - 24,693,851 (-)NCBI
Celera1123,853,696 - 24,069,048 (-)NCBICelera
RH 3.4 Map1194.7RGD
Cytogenetic Map11q11NCBI
App
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540725,722,849 - 25,974,268 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540725,725,259 - 25,973,582 (-)NCBIChiLan1.0ChiLan1.0
APP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12125,683,236 - 25,995,262 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2125,684,355 - 25,995,072 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02112,324,455 - 12,608,594 (-)NCBIMhudiblu_PPA_v0panPan3
APP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13121,351,207 - 21,614,466 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3121,351,207 - 21,614,337 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3121,345,590 - 21,608,332 (-)NCBI
ROS_Cfam_1.03121,405,966 - 21,669,000 (-)NCBI
UMICH_Zoey_3.13121,422,808 - 21,685,736 (-)NCBI
UNSW_CanFamBas_1.03121,425,054 - 21,689,657 (-)NCBI
UU_Cfam_GSD_1.03121,899,466 - 22,164,885 (-)NCBI
APP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13189,434,869 - 189,716,057 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113189,434,854 - 189,716,120 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213199,290,846 - 199,568,764 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103217727
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1266,037,224 - 66,320,860 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl266,037,261 - 66,321,306 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660718,700,007 - 8,984,223 (+)NCBIVero_WHO_p1.0
App
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474513,904,912 - 14,159,374 (-)NCBIHetGla_female_1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: XM_021733328   ⟹   XP_021589003
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0NW_0049366401,549,977 - 1,787,436 (+)NCBI
Sequence:
RefSeq Acc Id: XM_040287205   ⟹   XP_040143139
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440497121,893,758 - 22,131,543 (-)NCBI
Protein Sequences
Protein RefSeqs XP_040143139 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein KAG3283783 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_021589003   ⟸   XM_021733328
- Sequence:
RefSeq Acc Id: XP_040143139   ⟸   XM_040287205


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000008660 ENTREZGENE
NCBI Gene App ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-26 LOC101959175  amyloid beta precursor protein  App  amyloid beta precursor protein  Symbol and/or name change 5135510 APPROVED