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Gene: Ngfr (nerve growth factor receptor) Rattus norvegicus
Symbol: Ngfr
Name: nerve growth factor receptor
RGD ID: 3177
Description: Exhibits several functions, including amyloid-beta binding activity; nerve growth factor binding activity; and neurotrophin TRKA receptor binding activity. Involved in several processes, including positive regulation of cell communication; regulation of nervous system development; and regulation of neuron death. Localizes to several cellular components, including dendrite membrane; neuronal cell body membrane; and perikaryon. Used to study degenerative disc disease; glaucoma; hypertension; and middle cerebral artery infarction. Biomarker of several diseases, including brain disease (multiple); neuropathy (multiple); polycystic ovary syndrome; portal hypertension; and respiratory syncytial virus infectious disease. Human ortholog(s) of this gene implicated in Alzheimer's disease and mental depression. Orthologous to human NGFR (nerve growth factor receptor); PARTICIPATES IN cytokine mediated signaling pathway; neurotrophic factor signaling pathway; INTERACTS WITH (+)-pilocarpine; (+)-schisandrin B; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: gp80-LNGFR; LNGFR; low affinity nerve growth factor receptor; low affinity nerve growth factor receptor precursor; low affinity neurotrophin receptor p75NTR; low-affinity nerve growth factor receptor; nerve growth factor receptor (TNFR superfamily, member 16); Nerve growth factor receptor fast; Nerve growth factor receptor, fast; NGF receptor; p75; p75 ICD; p75NTR; RNNGFRR; Tnfrsf16; tumor necrosis factor receptor superfamily member 16
Homo sapiens (human) : NGFR (nerve growth factor receptor)  HGNC  Alliance
Mus musculus (house mouse) : Ngfr (nerve growth factor receptor (TNFR superfamily, member 16))  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ngfr (nerve growth factor receptor)
Pan paniscus (bonobo/pygmy chimpanzee) : NGFR (nerve growth factor receptor)
Canis lupus familiaris (dog) : NGFR (nerve growth factor receptor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ngfr (nerve growth factor receptor)
Sus scrofa (pig) : NGFR (nerve growth factor receptor)
Chlorocebus sabaeus (African green monkey) : NGFR (nerve growth factor receptor)
Heterocephalus glaber (naked mole-rat) : Ngfr (nerve growth factor receptor)
more info ...
Is Marker For: QTLs:   Bp134   Cm44   Cm75   Bw102  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01083,389,828 - 83,408,061 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1083,389,847 - 83,408,061 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01083,198,396 - 83,216,629 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41084,262,804 - 84,281,006 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11084,277,173 - 84,295,376 (-)NCBI
Celera1079,287,338 - 79,305,497 (-)NCBICelera
Cytogenetic Map10q26NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Ngfr
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3177
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-09-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.