RGD Reference Report - Sleep deprivation accelerates the progression of alzheimer's disease by influencing Aß-related metabolism. - Rat Genome Database

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Sleep deprivation accelerates the progression of alzheimer's disease by influencing Aß-related metabolism.

Authors: Chen, Lihong  Huang, Junshan  Yang, Lanfang  Zeng, Xue-Ai  Zhang, Ya  Wang, Xiufeng  Chen, Mingqi  Li, Xing  Zhang, Yifan  Zhang, Min 
Citation: Chen L, etal., Neurosci Lett. 2017 May 22;650:146-152. doi: 10.1016/j.neulet.2017.04.047. Epub 2017 Apr 25.
RGD ID: 13782059
Pubmed: (View Article at PubMed) PMID:28455102
DOI: Full-text: DOI:10.1016/j.neulet.2017.04.047

Sleep disorders have previously been connected with the neurodegenerative pathology of Alzheimer's disease (AD) due to the aggregation of ß-amyloid(Aß)peptides and tau proteinsinduced by sleep deprivation (SD). However, the underlying mechanisms remain unclear. Therefore, this study was performed to clarify how Aß-related metabolism is regulated after SD. Three-month-old Sprague-Dawley rats (250-300g) were randomly divided into 5 groups: two SD groups(i.e.,SD-2d and SD-4d), two platform control groups(i.e.,PC-2d and PC-4d) and a home cage control group (CC). For the two SD groups, themodified multiple platform method (MMPM) was used to induce SD.Our experiments confirmed that SD impaired cognitive function and increased the levels of Aß peptides, a hallmark of AD. Additionally, we found that SD significantly increasedthe levels of the ß-site amyloid precursor protein (APP)-cleaving enzyme 1(BACE1, ß-secretase), but had little impacton the levels of Aß-degradationenzymes.This resultmay be the main cause of the over-expression of Aß1-42 and Aß1-40. Our results suggested that SD accelerates the progression of AD bymodulating Aß-related metabolism. This findinghasimportant implications for the diagnosis and prevention of AD.

Annotation

Disease Annotations    

Objects Annotated

Genes (Rattus norvegicus)
Adam10  (ADAM metallopeptidase domain 10)
App  (amyloid beta precursor protein)
Bace1  (beta-secretase 1)

Genes (Mus musculus)
Adam10  (a disintegrin and metallopeptidase domain 10)
App  (amyloid beta (A4) precursor protein)
Bace1  (beta-site APP cleaving enzyme 1)

Genes (Homo sapiens)
ADAM10  (ADAM metallopeptidase domain 10)
APP  (amyloid beta precursor protein)
BACE1  (beta-secretase 1)


Additional Information