RGD Reference Report - Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP. - Rat Genome Database

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Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP.

Authors: Lewis, J  Dickson, DW  Lin, WL  Chisholm, L  Corral, A  Jones, G  Yen, SH  Sahara, N  Skipper, L  Yager, D  Eckman, C  Hardy, J  Hutton, M  McGowan, E 
Citation: Lewis J, etal., Science 2001 Aug 24;293(5534):1487-91.
RGD ID: 1302530
Pubmed: PMID:11520987   (View Abstract at PubMed)
DOI: DOI:10.1126/science.1058189   (Journal Full-text)

JNPL3 transgenic mice expressing a mutant tau protein, which develop neurofibrillary tangles and progressive motor disturbance, were crossed with Tg2576 transgenic mice expressing mutant beta-amyloid precursor protein (APP), thus modulating the APP-Abeta (beta-amyloid peptide) environment. The resulting double mutant (tau/APP) progeny and the Tg2576 parental strain developed Abeta deposits at the same age; however, relative to JNPL3 mice, the double mutants exhibited neurofibrillary tangle pathology that was substantially enhanced in the limbic system and olfactory cortex. These results indicate that either APP or Abeta influences the formation of neurofibrillary tangles. The interaction between Abeta and tau pathologies in these mice supports the hypothesis that a similar interaction occurs in Alzheimer's disease.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Alzheimer's disease  IMP 1302530; 1302530 RGD 
Alzheimer's disease  ISOAPP (Homo sapiens)1302530; 1302530 RGD 
Alzheimer's disease  ISO (All species)1302530; 1302530 RGD 

Objects Annotated

Genes (Rattus norvegicus)
App  (amyloid beta precursor protein)
Mapt  (microtubule-associated protein tau)

Genes (Mus musculus)
App  (amyloid beta precursor protein)
Mapt  (microtubule-associated protein tau)

Genes (Homo sapiens)
APP  (amyloid beta precursor protein)
MAPT  (microtubule associated protein tau)


Additional Information