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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2139
Species: Rattus norvegicus
RGD Object: Gene
Symbol: App
Name: amyloid beta precursor protein
Acc ID: CHEBI:68794
Term: neoechinulin A
Definition: An organic molecular entity that has formula C19H29N3O2.
Chemical ID: MESH:C490266
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Appmultiple interactionsISOApp (Mus musculus)6480464CTDneoechinulin A inhibits the reaction [[APP protein binds to APP protein binds to APP protein] which affects the localization of NFKB1 protein]; neoechinulin A inhibits the reaction [[APP protein binds to APP protein binds to APP protein] which affects the localization of RELA protein]; neoechinulin A inhibits the reaction [[APP protein binds to APP protein binds to APP protein] which results in increased abundance of Dinoprostone]; neoechinulin A inhibits the reaction [[APP protein binds to APP protein binds to APP protein] which results in increased expression of IL1B mRNA]; neoechinulin A inhibits the reaction [[APP protein binds to APP protein binds to APP protein] which results in increased expression of IL1B protein]; neoechinulin A inhibits the reaction [[APP protein binds to APP protein binds to APP protein] which results in increased expression of IL6 mRNA]; neoechinulin A inhibits the reaction [[APP protein binds to APP protein binds to APP protein] which results in increased expression of IL6 protein]; neoechinulin A inhibits the reaction [[APP protein binds to APP protein binds to APP protein] which results in increased expression of NOS2 mRNA]; neoechinulin A inhibits the reaction [[APP protein binds to APP protein binds to APP protein] which results in increased expression of NOS2 protein]; neoechinulin A inhibits the reaction [[APP protein binds to APP protein binds to APP protein] which results in increased expression of PTGS2 mRNA]; neoechinulin A inhibits the reaction [[APP protein binds to APP protein binds to APP protein] which results in increased expression of PTGS2 protein]; neoechinulin A inhibits the reaction [[APP protein binds to APP protein binds to APP protein] which results in increased expression of TNF mRNA]; neoechinulin A inhibits the reaction [[APP protein binds to APP protein binds to APP protein] which results in increased expression of TNF protein]; neoechinulin A inhibits the reaction [[APP protein binds to APP protein binds to APP protein] which results in increased phosphorylation of MAP3K5 protein]PMID:23261590
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