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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2139
Species: Rattus norvegicus
RGD Object: Gene
Symbol: App
Name: amyloid beta precursor protein
Acc ID: CHEBI:15351
Term: acetyl-CoA
Definition: An acyl-CoA having acetyl as its S-acetyl component.
Chemical ID: MESH:D000105
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Appaffects localizationISORGD:7360226480464CTDAPP protein affects the localization of Acetyl Coenzyme A

PMID:16122837
Appincreases secretionISORGD:7360216480464CTDAcetyl Coenzyme A results in increased secretion of APP protein modified form

PMID:22906069
Appmultiple interactionsISORGD:7360216480464CTDAcetyl Coenzyme A inhibits the reaction [Hydrogen Peroxide results in decreased secretion of APP protein modified form]

PMID:22906069
Appmultiple interactionsISORGD:7360226480464CTDIL1B protein affects the reaction [APP protein affects the localization of Acetyl Coenzyme A]

PMID:16122837
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