Gene Chemical Interaction Report - Rat Genome Database

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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	2139
Species:	Rattus norvegicus
RGD Object:	Gene
Symbol:	App
Name:	amyloid beta precursor protein

Acc ID:	CHEBI:15351
Term:	acetyl-CoA
Definition:	An acyl-CoA having acetyl as its S-acetyl component.
Chemical ID:	MESH:D000105

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
App	affects localization	ISO	RGD:736022	6480464	CTD	APP protein affects the localization of Acetyl Coenzyme A	PMID:16122837
App	increases secretion	ISO	RGD:736021	6480464	CTD	Acetyl Coenzyme A results in increased secretion of APP protein modified form	PMID:22906069
App	multiple interactions	ISO	RGD:736021	6480464	CTD	Acetyl Coenzyme A inhibits the reaction [Hydrogen Peroxide results in decreased secretion of APP protein modified form]	PMID:22906069
App	multiple interactions	ISO	RGD:736022	6480464	CTD	IL1B protein affects the reaction [APP protein affects the localization of Acetyl Coenzyme A]	PMID:16122837

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