APP (amyloid beta precursor protein) - Rat Genome Database

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Gene: APP (amyloid beta precursor protein) Canis lupus familiaris
Analyze
Symbol: APP
Name: amyloid beta precursor protein
RGD ID: 12199021
Description: ENCODES a protein that exhibits acetylcholine receptor binding (ortholog); apolipoprotein binding (ortholog); chaperone binding (ortholog); INVOLVED IN adenylate cyclase-activating G protein-coupled receptor signaling pathway (ortholog); adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway (ortholog); adult locomotory behavior (ortholog); PARTICIPATES IN glypican signaling pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); Alzheimer's disease 1 (ortholog); Alzheimer's Disease, Early-Onset, with Cerebral Amyloid Angiopathy (ortholog); FOUND IN amyloid-beta complex (ortholog); astrocyte projection (ortholog); cell body (ortholog); INTERACTS WITH copper atom; copper(0)
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ABPP; alzheimer disease amyloid A4 protein homolog; amyloid beta (A4) precursor protein (peptidase nexin-II, Alzheimer disease); amyloid beta A4 protein; amyloid precursor protein; beta-amyloid precursor protein
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13121,351,207 - 21,614,466 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3121,351,207 - 21,614,337 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3121,345,590 - 21,608,332 (-)NCBI
ROS_Cfam_1.03121,405,966 - 21,669,000 (-)NCBI
ROS_Cfam_1.0 Ensembl3121,405,966 - 21,668,874 (-)Ensembl
UMICH_Zoey_3.13121,422,808 - 21,685,736 (-)NCBI
UNSW_CanFamBas_1.03121,425,054 - 21,689,657 (-)NCBI
UU_Cfam_GSD_1.03121,899,466 - 22,164,885 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
copper atom  (EXP)
copper(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenylate cyclase-activating G protein-coupled receptor signaling pathway  (ISO)
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway  (ISO)
adult locomotory behavior  (IEA,ISO)
amyloid fibril formation  (IEA)
antibacterial humoral response  (ISO)
antifungal humoral response  (ISO)
antimicrobial humoral immune response mediated by antimicrobial peptide  (ISO)
apoptotic process  (IEA)
associative learning  (ISO)
astrocyte activation  (IEA)
astrocyte activation involved in immune response  (IEA)
axo-dendritic transport  (IEA,ISO)
axon midline choice point recognition  (IEA,ISO)
axonogenesis  (IBA,IEA,ISO)
calcium-mediated signaling  (ISO)
cell adhesion  (IEA)
cellular copper ion homeostasis  (IEA,ISO)
cellular response to amyloid-beta  (IEA)
cellular response to cAMP  (ISO)
cellular response to copper ion  (ISO)
cellular response to manganese ion  (ISO)
cellular response to nerve growth factor stimulus  (ISO)
cellular response to norepinephrine stimulus  (ISO)
central nervous system development  (IBA)
chemical synaptic transmission  (ISO)
cholesterol metabolic process  (IEA,ISO)
cognition  (IEA,ISS)
collateral sprouting in absence of injury  (IEA,ISO)
defense response to Gram-negative bacterium  (ISO)
defense response to Gram-positive bacterium  (ISO)
dendrite development  (IEA,ISO)
endocytosis  (IEA,ISO)
extracellular matrix organization  (IEA,ISO)
forebrain development  (IEA,ISO)
G protein-coupled receptor signaling pathway  (ISO)
G2/M transition of mitotic cell cycle  (IEA,ISO)
innate immune response  (ISO)
ionotropic glutamate receptor signaling pathway  (IEA,ISO)
learning  (IEA)
learning or memory  (IEA)
locomotory behavior  (IEA,ISO)
mating behavior  (IEA,ISO)
memory  (ISO)
microglia development  (IEA)
microglial cell activation  (IEA)
mitotic cell cycle  (IEA,ISO)
modulation of excitatory postsynaptic potential  (IEA)
mRNA polyadenylation  (IEA,ISO)
negative regulation of blood circulation  (ISO)
negative regulation of canonical Wnt signaling pathway  (ISO)
negative regulation of cell population proliferation  (IEA)
negative regulation of dendritic spine maintenance  (ISO)
negative regulation of endopeptidase activity  (IEA)
negative regulation of gene expression  (IEA)
negative regulation of long-term synaptic potentiation  (IEA)
negative regulation of low-density lipoprotein receptor activity  (ISO)
negative regulation of miRNA transcription  (ISO)
negative regulation of neuron death  (ISO)
negative regulation of neuron differentiation  (IEA,ISO)
negative regulation of peptidase activity  (IEA)
negative regulation of protein localization to nucleus  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
negative regulation of Wnt signaling pathway  (ISO)
nervous system development  (IEA)
neuromuscular process controlling balance  (IEA,ISO)
neuron apoptotic process  (IEA,ISO)
neuron cellular homeostasis  (IEA,ISO)
neuron differentiation  (IEA,ISO)
neuron projection development  (IEA,ISO)
neuron projection maintenance  (IEA)
neuron remodeling  (IEA,ISO)
Notch signaling pathway  (IEA)
obsolete modulation of age-related behavioral decline  (IEA)
positive regulation of 1-phosphatidylinositol-3-kinase activity  (ISO)
positive regulation of amyloid fibril formation  (IEA)
positive regulation of apoptotic process  (ISO)
positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process  (ISO)
positive regulation of cellular response to thapsigargin  (ISO)
positive regulation of cellular response to tunicamycin  (ISO)
positive regulation of chemokine production  (IEA)
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process  (ISO)
positive regulation of DNA-binding transcription factor activity  (IEA)
positive regulation of endothelin production  (ISO)
positive regulation of ERK1 and ERK2 cascade  (IEA)
positive regulation of excitatory postsynaptic potential  (ISO)
positive regulation of G protein-coupled receptor internalization  (ISO)
positive regulation of G protein-coupled receptor signaling pathway  (ISO)
positive regulation of G2/M transition of mitotic cell cycle  (IEA,ISO)
positive regulation of gene expression  (IEA)
positive regulation of glycolytic process  (IEA)
positive regulation of histone acetylation  (ISO)
positive regulation of inflammatory response  (IEA)
positive regulation of interferon-gamma production  (ISO)
positive regulation of interleukin-1 beta production  (IEA)
positive regulation of interleukin-6 production  (IEA)
positive regulation of JNK cascade  (IEA)
positive regulation of long-term synaptic depression  (ISO)
positive regulation of long-term synaptic potentiation  (IEA)
positive regulation of MAP kinase activity  (ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of membrane protein ectodomain proteolysis  (ISO)
positive regulation of mitotic cell cycle  (IEA,ISO)
positive regulation of monocyte chemotaxis  (ISO)
positive regulation of neuron apoptotic process  (ISO)
positive regulation of neuron death  (ISO)
positive regulation of neuron differentiation  (ISO)
positive regulation of NF-kappaB transcription factor activity  (IEA)
positive regulation of NIK/NF-kappaB signaling  (IEA)
positive regulation of nitric oxide biosynthetic process  (ISO)
positive regulation of oxidative stress-induced neuron death  (ISO)
positive regulation of peptidyl-serine phosphorylation  (IEA)
positive regulation of peptidyl-threonine phosphorylation  (IEA)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of phosphorylation  (IEA)
positive regulation of protein binding  (IEA)
positive regulation of protein import  (ISO)
positive regulation of protein metabolic process  (IEA)
positive regulation of protein phosphorylation  (IEA)
positive regulation of protein tyrosine kinase activity  (ISO)
positive regulation of receptor binding  (ISO)
positive regulation of response to endoplasmic reticulum stress  (ISO)
positive regulation of superoxide anion generation  (ISO)
positive regulation of T cell migration  (IEA)
positive regulation of tau-protein kinase activity  (ISO)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response  (ISO)
positive regulation of tumor necrosis factor production  (IEA)
protein homooligomerization  (ISO)
protein phosphorylation  (IEA,ISO)
protein tetramerization  (ISO)
protein trimerization  (ISO)
regulation of acetylcholine-gated cation channel activity  (ISO)
regulation of amyloid fibril formation  (ISO)
regulation of amyloid-beta clearance  (ISO)
regulation of calcium ion transmembrane transport via high voltage-gated calcium channel  (ISO)
regulation of cellular protein metabolic process  (IEA)
regulation of dendritic spine maintenance  (ISO)
regulation of epidermal growth factor-activated receptor activity  (IEA,ISO)
regulation of gene expression  (IEA,ISO)
regulation of long-term neuronal synaptic plasticity  (IEA)
regulation of MAPK cascade  (ISO)
regulation of multicellular organism growth  (IEA,ISO)
regulation of peptidyl-tyrosine phosphorylation  (IEA)
regulation of presynapse assembly  (IEA)
regulation of protein binding  (IEA,ISO)
regulation of protein tyrosine kinase activity  (ISO)
regulation of response to calcium ion  (ISO)
regulation of signaling receptor activity  (ISO)
regulation of spontaneous synaptic transmission  (IEA)
regulation of synapse structure or activity  (IEA,ISO)
regulation of toll-like receptor signaling pathway  (ISO)
regulation of transcription by RNA polymerase II  (ISO)
regulation of translation  (IEA,ISO)
response to auditory stimulus  (ISO)
response to interleukin-1  (ISO)
response to lead ion  (ISO)
response to oxidative stress  (IEA,ISO)
response to radiation  (ISO)
response to yeast  (ISO)
smooth endoplasmic reticulum calcium ion homeostasis  (IEA,ISO)
suckling behavior  (IEA,ISO)
synapse organization  (IEA)
synaptic assembly at neuromuscular junction  (IEA,ISO)
visual learning  (IEA,ISO)

Cellular Component
amyloid-beta complex  (ISO)
apical part of cell  (IEA)
astrocyte projection  (ISO)
axon  (IEA)
cell body  (ISO)
cell projection  (IEA)
cell surface  (IBA,IEA,ISO)
cell-cell junction  (IEA)
ciliary rootlet  (IEA)
clathrin-coated pit  (IEA)
COPII-coated ER to Golgi transport vesicle  (IEA)
cytoplasm  (IEA,ISO)
cytoplasmic vesicle  (IEA)
dendrite  (ISO)
dendrite membrane  (ISO)
dendritic shaft  (IEA)
dendritic spine  (IEA)
early endosome  (IBA,IEA,ISS)
endoplasmic reticulum  (IEA)
endosome  (IEA)
endosome to plasma membrane transport vesicle  (ISO)
extracellular region  (IEA)
extracellular space  (IEA,ISO)
extrinsic component of external side of plasma membrane  (ISO)
Golgi apparatus  (IBA,IEA,ISO)
Golgi-associated vesicle  (IEA,ISS)
growth cone  (IEA,ISO)
growth cone filopodium  (ISO)
growth cone lamellipodium  (ISO)
high-density lipoprotein particle  (ISO)
integral component of membrane  (IEA)
intermediate-density lipoprotein particle  (ISO)
lipoprotein particle  (ISO)
low-density lipoprotein particle  (ISO)
lysosome  (ISO)
main axon  (ISO)
membrane  (IEA)
membrane raft  (IBA,IEA,ISO)
mitochondrion  (ISO)
neuromuscular junction  (IEA)
neuron projection  (IEA,ISO)
nuclear envelope lumen  (IEA)
nucleus  (IEA)
perikaryon  (IEA)
perinuclear region of cytoplasm  (IEA)
plasma membrane  (IBA,IEA,ISO)
postsynapse  (ISO)
presynapse  (ISO)
presynaptic active zone  (IEA)
protein-containing complex  (ISO)
receptor complex  (IEA)
recycling endosome  (IEA,ISS)
rough endoplasmic reticulum  (ISO)
smooth endoplasmic reticulum  (IEA)
spindle midzone  (IEA)
synapse  (IEA)
synaptic membrane  (ISO)
synaptic vesicle  (IEA,ISO)
very-low-density lipoprotein particle  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:1656157   PMID:11214319   PMID:16775693   PMID:20875843   PMID:21177866   PMID:21377518   PMID:32970242  


Genomics

Comparative Map Data
APP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13121,351,207 - 21,614,466 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3121,351,207 - 21,614,337 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3121,345,590 - 21,608,332 (-)NCBI
ROS_Cfam_1.03121,405,966 - 21,669,000 (-)NCBI
ROS_Cfam_1.0 Ensembl3121,405,966 - 21,668,874 (-)Ensembl
UMICH_Zoey_3.13121,422,808 - 21,685,736 (-)NCBI
UNSW_CanFamBas_1.03121,425,054 - 21,689,657 (-)NCBI
UU_Cfam_GSD_1.03121,899,466 - 22,164,885 (-)NCBI
APP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382125,880,550 - 26,171,128 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl2125,880,550 - 26,171,128 (-)EnsemblGRCh38hg38GRCh38
GRCh372127,252,861 - 27,543,446 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362126,174,732 - 26,465,003 (-)NCBINCBI36hg18NCBI36
Build 342126,174,732 - 26,465,003NCBI
Celera2112,436,275 - 12,726,567 (-)NCBI
Cytogenetic Map21q21.3NCBI
HuRef2112,656,350 - 12,947,965 (-)NCBIHuRef
CHM1_12126,813,502 - 27,104,969 (-)NCBICHM1_1
App
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391684,751,236 - 84,972,187 (-)NCBIGRCm39mm39
GRCm39 Ensembl1684,746,573 - 84,970,654 (-)Ensembl
GRCm381684,952,666 - 85,175,255 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1684,949,685 - 85,173,766 (-)EnsemblGRCm38mm10GRCm38
MGSCv371684,954,688 - 85,173,948 (-)NCBIGRCm37mm9NCBIm37
MGSCv361684,837,873 - 85,057,149 (-)NCBImm8
Celera1685,161,866 - 85,382,753 (-)NCBICelera
Cytogenetic Map16C3.3NCBI
cM Map1646.92NCBI
App
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21124,019,774 - 24,236,584 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1124,019,778 - 24,236,561 (-)Ensembl
Rnor_6.01124,425,013 - 24,641,872 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1124,425,005 - 24,641,858 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01128,048,897 - 28,265,250 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41124,457,855 - 24,693,851 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11124,457,854 - 24,693,851 (-)NCBI
Celera1123,853,696 - 24,069,048 (-)NCBICelera
RH 3.4 Map1194.7RGD
Cytogenetic Map11q11NCBI
App
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540725,722,849 - 25,974,268 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540725,725,259 - 25,973,582 (-)NCBIChiLan1.0ChiLan1.0
APP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12125,683,236 - 25,995,262 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2125,684,355 - 25,995,072 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02112,324,455 - 12,608,594 (-)NCBIMhudiblu_PPA_v0panPan3
LOC101959175
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440497121,893,758 - 22,131,543 (-)NCBI
SpeTri2.0NW_0049366401,549,977 - 1,787,436 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
APP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13189,434,869 - 189,716,057 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113189,434,854 - 189,716,120 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213199,290,846 - 199,568,764 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103217727
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1266,037,224 - 66,320,860 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl266,037,261 - 66,321,306 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660718,700,007 - 8,984,223 (+)NCBIVero_WHO_p1.0
App
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474513,904,912 - 14,159,374 (-)NCBIHetGla_female_1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 5 22 6 6 6 6 3 12 8 10 6
Low 3
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001006601 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001293275 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001293276 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001293279 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005638725 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005638728 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005638731 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038443098 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038443099 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038443100 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000031 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY011372 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY498706 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY498707 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY498708 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY926579 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY926580 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY926581 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY926582 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CO680263 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DN394364 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DN877827 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000315 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000076 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000279 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000031 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X56125 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCAFT00000013593   ⟹   ENSCAFP00000012578
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3121,351,207 - 21,614,337 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000013595   ⟹   ENSCAFP00000012580
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3121,351,207 - 21,614,337 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000013599   ⟹   ENSCAFP00000012583
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3121,351,207 - 21,614,337 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000037829   ⟹   ENSCAFP00000033451
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3121,351,207 - 21,614,337 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000066450   ⟹   ENSCAFP00000048970
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3121,351,207 - 21,614,337 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000071777   ⟹   ENSCAFP00000047364
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3121,351,207 - 21,614,319 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000077278   ⟹   ENSCAFP00000060503
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3121,351,207 - 21,555,304 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845030063   ⟹   ENSCAFP00845023583
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl3121,405,966 - 21,668,874 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845030144   ⟹   ENSCAFP00845023645
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl3121,405,966 - 21,668,874 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845030217   ⟹   ENSCAFP00845023694
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl3121,405,966 - 21,668,874 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845030292   ⟹   ENSCAFP00845023754
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl3121,405,966 - 21,668,874 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845030397   ⟹   ENSCAFP00845023839
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl3121,405,966 - 21,668,874 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845030552   ⟹   ENSCAFP00845023967
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl3121,405,966 - 21,668,874 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845030690   ⟹   ENSCAFP00845024079
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl3121,405,966 - 21,668,856 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845030921   ⟹   ENSCAFP00845024232
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl3121,405,966 - 21,609,962 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845031030   ⟹   ENSCAFP00845024314
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl3121,415,182 - 21,668,874 (-)Ensembl
RefSeq Acc Id: NM_001006601   ⟹   NP_001006601
RefSeq Status: VALIDATED
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.13121,351,207 - 21,614,337 (-)NCBI
Dog10K_Boxer_Tasha3121,345,590 - 21,608,332 (-)NCBI
ROS_Cfam_1.03121,405,966 - 21,668,874 (-)NCBI
UMICH_Zoey_3.13121,422,808 - 21,685,736 (-)NCBI
UNSW_CanFamBas_1.03121,425,054 - 21,689,657 (-)NCBI
UU_Cfam_GSD_1.03121,899,466 - 22,164,885 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001293275   ⟹   NP_001280204
RefSeq Status: VALIDATED
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.13121,351,207 - 21,614,337 (-)NCBI
Dog10K_Boxer_Tasha3121,345,590 - 21,608,332 (-)NCBI
ROS_Cfam_1.03121,405,966 - 21,668,874 (-)NCBI
UMICH_Zoey_3.13121,422,808 - 21,685,736 (-)NCBI
UNSW_CanFamBas_1.03121,425,054 - 21,689,657 (-)NCBI
UU_Cfam_GSD_1.03121,899,466 - 22,164,885 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001293276   ⟹   NP_001280205
RefSeq Status: VALIDATED
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.13121,351,207 - 21,614,337 (-)NCBI
Dog10K_Boxer_Tasha3121,345,590 - 21,608,332 (-)NCBI
ROS_Cfam_1.03121,405,966 - 21,668,874 (-)NCBI
UMICH_Zoey_3.13121,422,808 - 21,685,736 (-)NCBI
UNSW_CanFamBas_1.03121,425,054 - 21,689,657 (-)NCBI
UU_Cfam_GSD_1.03121,899,466 - 22,164,885 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001293279   ⟹   NP_001280208
RefSeq Status: VALIDATED
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.13121,351,207 - 21,614,337 (-)NCBI
Dog10K_Boxer_Tasha3121,345,590 - 21,608,332 (-)NCBI
ROS_Cfam_1.03121,405,966 - 21,668,874 (-)NCBI
UMICH_Zoey_3.13121,422,808 - 21,685,736 (-)NCBI
UNSW_CanFamBas_1.03121,425,054 - 21,689,657 (-)NCBI
UU_Cfam_GSD_1.03121,899,466 - 22,164,885 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038443098   ⟹   XP_038299026
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.03121,405,966 - 21,669,000 (-)NCBI
RefSeq Acc Id: XM_038443099   ⟹   XP_038299027
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.03121,405,966 - 21,669,000 (-)NCBI
RefSeq Acc Id: XM_038443100   ⟹   XP_038299028
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.03121,405,966 - 21,669,000 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_001280208   ⟸   NM_001293279
- Peptide Label: isoform APP-695 precursor
- UniProtKB: F1PC71 (UniProtKB/TrEMBL),   Q56JK6 (UniProtKB/TrEMBL),   Q6RH29 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001280205   ⟸   NM_001293276
- Peptide Label: isoform APP-714 precursor
- UniProtKB: F1P615 (UniProtKB/TrEMBL),   Q56JK4 (UniProtKB/TrEMBL),   Q56JK6 (UniProtKB/TrEMBL),   Q6RH28 (UniProtKB/TrEMBL),   Q6RH30 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001280204   ⟸   NM_001293275
- Peptide Label: isoform APP-751 precursor
- UniProtKB: F1P606 (UniProtKB/TrEMBL),   Q56JK6 (UniProtKB/TrEMBL),   Q6RH28 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001006601   ⟸   NM_001006601
- Peptide Label: isoform APP-770 precursor
- UniProtKB: F1P603 (UniProtKB/TrEMBL),   Q56JK6 (UniProtKB/TrEMBL),   Q6RH30 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000060503   ⟸   ENSCAFT00000077278
RefSeq Acc Id: ENSCAFP00000048970   ⟸   ENSCAFT00000066450
RefSeq Acc Id: ENSCAFP00000012580   ⟸   ENSCAFT00000013595
RefSeq Acc Id: ENSCAFP00000012583   ⟸   ENSCAFT00000013599
RefSeq Acc Id: ENSCAFP00000012578   ⟸   ENSCAFT00000013593
RefSeq Acc Id: ENSCAFP00000033451   ⟸   ENSCAFT00000037829
RefSeq Acc Id: ENSCAFP00000047364   ⟸   ENSCAFT00000071777
RefSeq Acc Id: XP_038299028   ⟸   XM_038443100
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038299027   ⟸   XM_038443099
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038299026   ⟸   XM_038443098
- Peptide Label: isoform X1
RefSeq Acc Id: ENSCAFP00845023839   ⟸   ENSCAFT00845030397
RefSeq Acc Id: ENSCAFP00845023967   ⟸   ENSCAFT00845030552
RefSeq Acc Id: ENSCAFP00845023754   ⟸   ENSCAFT00845030292
RefSeq Acc Id: ENSCAFP00845023583   ⟸   ENSCAFT00845030063
RefSeq Acc Id: ENSCAFP00845024232   ⟸   ENSCAFT00845030921
RefSeq Acc Id: ENSCAFP00845024079   ⟸   ENSCAFT00845030690
RefSeq Acc Id: ENSCAFP00845024314   ⟸   ENSCAFT00845031030
RefSeq Acc Id: ENSCAFP00845023645   ⟸   ENSCAFT00845030144
RefSeq Acc Id: ENSCAFP00845023694   ⟸   ENSCAFT00845030217
Protein Domains
BPTI/Kunitz inhibitor   E1   E2


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000008557 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030017648 UniProtKB/TrEMBL
  ENSCAFG00040019408 UniProtKB/TrEMBL
  ENSCAFG00845015660 Ensembl, ENTREZGENE
Ensembl Protein ENSCAFP00000012578 UniProtKB/TrEMBL
  ENSCAFP00000012580 UniProtKB/TrEMBL
  ENSCAFP00000012583 UniProtKB/TrEMBL
  ENSCAFP00000033451 UniProtKB/TrEMBL
  ENSCAFP00000047364 UniProtKB/TrEMBL
  ENSCAFP00000048970 UniProtKB/TrEMBL
  ENSCAFP00000060503 UniProtKB/TrEMBL
  ENSCAFP00030028445 UniProtKB/TrEMBL
  ENSCAFP00030028573 UniProtKB/TrEMBL
  ENSCAFP00030028693 UniProtKB/TrEMBL
  ENSCAFP00030028826 UniProtKB/TrEMBL
  ENSCAFP00030028942 UniProtKB/TrEMBL
  ENSCAFP00030029032 UniProtKB/TrEMBL
  ENSCAFP00030029158 UniProtKB/TrEMBL
  ENSCAFP00030029301 UniProtKB/TrEMBL
  ENSCAFP00030029437 UniProtKB/TrEMBL
  ENSCAFP00040035069 UniProtKB/TrEMBL
  ENSCAFP00040035099 UniProtKB/TrEMBL
  ENSCAFP00040035125 UniProtKB/TrEMBL
  ENSCAFP00040035154 UniProtKB/TrEMBL
  ENSCAFP00040035182 UniProtKB/TrEMBL
  ENSCAFP00040035226 UniProtKB/TrEMBL
  ENSCAFP00040035375 UniProtKB/TrEMBL
  ENSCAFP00845023583 ENTREZGENE
  ENSCAFP00845023645 ENTREZGENE
  ENSCAFP00845023694 ENTREZGENE
  ENSCAFP00845023754 ENTREZGENE
  ENSCAFP00845023839 ENTREZGENE
Ensembl Transcript ENSCAFT00000013593 UniProtKB/TrEMBL
  ENSCAFT00000013595 UniProtKB/TrEMBL
  ENSCAFT00000013599 UniProtKB/TrEMBL
  ENSCAFT00000037829 UniProtKB/TrEMBL
  ENSCAFT00000066450 UniProtKB/TrEMBL
  ENSCAFT00000071777 UniProtKB/TrEMBL
  ENSCAFT00000077278 UniProtKB/TrEMBL
  ENSCAFT00030032606 UniProtKB/TrEMBL
  ENSCAFT00030032744 UniProtKB/TrEMBL
  ENSCAFT00030032892 UniProtKB/TrEMBL
  ENSCAFT00030033047 UniProtKB/TrEMBL
  ENSCAFT00030033176 UniProtKB/TrEMBL
  ENSCAFT00030033274 UniProtKB/TrEMBL
  ENSCAFT00030033418 UniProtKB/TrEMBL
  ENSCAFT00030033577 UniProtKB/TrEMBL
  ENSCAFT00030033744 UniProtKB/TrEMBL
  ENSCAFT00040040182 UniProtKB/TrEMBL
  ENSCAFT00040040218 UniProtKB/TrEMBL
  ENSCAFT00040040245 UniProtKB/TrEMBL
  ENSCAFT00040040283 UniProtKB/TrEMBL
  ENSCAFT00040040319 UniProtKB/TrEMBL
  ENSCAFT00040040377 UniProtKB/TrEMBL
  ENSCAFT00040040556 UniProtKB/TrEMBL
  ENSCAFT00845030063 ENTREZGENE
  ENSCAFT00845030144 ENTREZGENE
  ENSCAFT00845030217 ENTREZGENE
  ENSCAFT00845030292 ENTREZGENE
  ENSCAFT00845030397 ENTREZGENE
Gene3D-CATH 1.20.120.770 UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/TrEMBL
  3.30.1490.140 UniProtKB/TrEMBL
  3.90.570.10 UniProtKB/TrEMBL
  4.10.230.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  4.10.410.10 UniProtKB/TrEMBL
InterPro Amyloid_Cu-bd_sf UniProtKB/TrEMBL
  Amyloid_glyco UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Amyloid_glyco_Abeta UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Amyloid_glyco_Abeta_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Amyloid_glyco_Cu-bd UniProtKB/TrEMBL
  Amyloid_glyco_E2_domain UniProtKB/TrEMBL
  Amyloid_glyco_extra UniProtKB/TrEMBL
  Amyloid_glyco_heparin-bd UniProtKB/TrEMBL
  Amyloid_glyco_heparin-bd_sf UniProtKB/TrEMBL
  Amyloid_glyco_intracell_CS UniProtKB/TrEMBL
  APP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  APP_amyloid_C UniProtKB/TrEMBL
  APP_CUBD_CS UniProtKB/TrEMBL
  E2_sf UniProtKB/TrEMBL
  Kunitz_BPTI UniProtKB/TrEMBL
  Kunitz_BPTI_sf UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/TrEMBL
  Prtase_inh_Kunz-CS UniProtKB/TrEMBL
KEGG Report cfa:403407 UniProtKB/TrEMBL
NCBI Gene APP ENTREZGENE
PANTHER PTHR23103 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR23103:SF7 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam APP_amyloid UniProtKB/TrEMBL
  APP_Cu_bd UniProtKB/TrEMBL
  APP_E2 UniProtKB/TrEMBL
  APP_N UniProtKB/TrEMBL
  Beta-APP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kunitz_BPTI UniProtKB/TrEMBL
PRINTS AMYLOIDA4 UniProtKB/TrEMBL
  BASICPTASE UniProtKB/TrEMBL
  BETAAMYLOID UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE APP_CUBD UniProtKB/TrEMBL
  APP_E1 UniProtKB/TrEMBL
  APP_E2 UniProtKB/TrEMBL
  APP_INTRA UniProtKB/TrEMBL
  BPTI_KUNITZ_1 UniProtKB/TrEMBL
  BPTI_KUNITZ_2 UniProtKB/TrEMBL
SMART A4_EXTRA UniProtKB/TrEMBL
  SM00131 UniProtKB/TrEMBL
Superfamily-SCOP SSF109843 UniProtKB/TrEMBL
  SSF56491 UniProtKB/TrEMBL
  SSF57362 UniProtKB/TrEMBL
  SSF89811 UniProtKB/TrEMBL
UniProt A0A5F4BZJ4_CANLF UniProtKB/TrEMBL
  A0A5F4C409_CANLF UniProtKB/TrEMBL
  A0A5F4D1V3_CANLF UniProtKB/TrEMBL
  A0A8C0NLH2_CANLF UniProtKB/TrEMBL
  A0A8C0NN75_CANLF UniProtKB/TrEMBL
  A0A8C0NNJ0_CANLF UniProtKB/TrEMBL
  A0A8C0NP81_CANLF UniProtKB/TrEMBL
  A0A8C0NTA4_CANLF UniProtKB/TrEMBL
  A0A8C0NZF0_CANLF UniProtKB/TrEMBL
  A0A8C0P301_CANLF UniProtKB/TrEMBL
  A0A8C0TD40_CANLF UniProtKB/TrEMBL
  A0A8C0TFK8_CANLF UniProtKB/TrEMBL
  A0A8C0TFV8_CANLF UniProtKB/TrEMBL
  A0A8C0TG24_CANLF UniProtKB/TrEMBL
  A0A8C0TG86_CANLF UniProtKB/TrEMBL
  A0A8C0TGH9_CANLF UniProtKB/TrEMBL
  A0A8C0Z3X8_CANLF UniProtKB/TrEMBL
  A4_CANLF UniProtKB/Swiss-Prot
  F1P603 ENTREZGENE, UniProtKB/TrEMBL
  F1P606 ENTREZGENE, UniProtKB/TrEMBL
  F1P615 ENTREZGENE, UniProtKB/TrEMBL
  F1PC71 ENTREZGENE, UniProtKB/TrEMBL
  Q28280 ENTREZGENE
  Q56JK4 ENTREZGENE, UniProtKB/TrEMBL
  Q56JK6 ENTREZGENE, UniProtKB/TrEMBL
  Q6RH28 ENTREZGENE, UniProtKB/TrEMBL
  Q6RH29 ENTREZGENE, UniProtKB/TrEMBL
  Q6RH30 ENTREZGENE, UniProtKB/TrEMBL
  Q9BFR6_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:38010 ENTREZGENE