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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2139
Species: Rattus norvegicus
RGD Object: Gene
Symbol: App
Name: amyloid beta precursor protein
Acc ID: CHEBI:34310
Term: (24S)-24-hydroxycholesterol
Definition: A 24-hydroxycholesterol that has S configuration at position 24. It is the major metabolic breakdown product of cholesterol in the brain.
Chemical ID: MESH:C044563
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Appincreases metabolic processingISOAPP (Homo sapiens)6480464CTD24-hydroxycholesterol results in increased metabolism of APP proteinPMID:19126211
Appmultiple interactionsISOAPP (Homo sapiens)6480464CTD24-hydroxycholesterol affects the metabolism of and results in increased activity of APP protein; 24-hydroxycholesterol results in decreased metabolism of and results in decreased secretion of APP proteinPMID:15148325 PMID:17532301
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