APP (amyloid beta precursor protein) - Rat Genome Database

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Gene: APP (amyloid beta precursor protein) Homo sapiens
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Symbol: APP
Name: amyloid beta precursor protein
RGD ID: 736021
HGNC Page HGNC
Description: Exhibits several functions, including PTB domain binding activity; protein dimerization activity; and signaling receptor binding activity. Involved in several processes, including defense response to other organism; modulation of chemical synaptic transmission; and positive regulation of macromolecule metabolic process. Localizes to several cellular components, including amyloid-beta complex; cytoplasmic vesicle; and dendrite. Colocalizes with several cellular components, including cell body; low-density lipoprotein particle; and very-low-density lipoprotein particle. Implicated in APP-related cerebral amyloid angiopathy; Alzheimer's disease; Alzheimer's disease 1; cognitive disorder; and visual epilepsy. Biomarker of Alzheimer's disease; obesity; and periodontitis.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AAA; ABETA; ABPP; AD1; alpha-sAPP; alzheimer disease amyloid protein; amyloid beta (A4) precursor protein (peptidase nexin-II, Alzheimer disease); amyloid beta A4 protein; APPI; beta-amyloid peptide; beta-amyloid peptide(1-40); beta-amyloid peptide(1-42); cerebral vascular amyloid peptide; CTFgamma; CVAP; peptidase nexin-II; PN-II; PN2; preA4; protease nexin-II; testicular tissue protein Li 2
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Is Marker For: Strains:   SD-Tg(UbC-APPswe)6590   F344-Tg(APP)21Besey  
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2125,880,550 - 26,171,128 (-)EnsemblGRCh38hg38GRCh38
GRCh382125,880,550 - 26,171,128 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372127,252,861 - 27,543,446 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362126,174,732 - 26,465,003 (-)NCBINCBI36hg18NCBI36
Build 342126,174,732 - 26,465,003NCBI
Celera2112,436,275 - 12,726,567 (-)NCBI
Cytogenetic Map21q21.3NCBI
HuRef2112,656,350 - 12,947,965 (-)NCBIHuRef
CHM1_12126,813,502 - 27,104,969 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model