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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2139
Species: Rattus norvegicus
RGD Object: Gene
Symbol: App
Name: amyloid beta precursor protein
Acc ID: CHEBI:15372
Term: 5,6,7,8-tetrahydrobiopterin
Definition: A biopterin that has formula C9H15N5O3.
Chemical ID: MESH:C003402
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Appmultiple interactionsISORGD:7360216480464CTDAPP gene mutant form results in increased oxidation of and results in decreased abundance of sapropterin GW 501516 inhibits the reaction [APP gene mutant form results in increased oxidation of and results in decreased abundance of sapropterin]

PMID:22886847
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