Imported Disease Annotations - CTDObject Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | IDE | Human | Alzheimer's disease | | EXP | | 11554173 | CTD Direct Evidence: marker/mechanism | CTD | PMID:17192785 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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References
References - curated
| # | Reference Title | Reference Citation |
| 1. | Treadmill Running and Rutin Reverse High Fat Diet Induced Cognitive Impairment in Diet Induced Obese Mice. | Cheng J, etal., J Nutr Health Aging. 2016;20(5):503-8. doi: 10.1007/s12603-015-0616-7. |
| 2. | Change in INSR, APBA2 and IDE Gene Expressions in Brains of Alzheimer's Disease Patients. | da Costa IB, etal., Curr Alzheimer Res. 2017;14(7):760-765. doi: 10.2174/1567205014666170203100734. |
| 3. | Insulin-degrading enzyme identified as a candidate diabetes susceptibility gene in GK rats. | Fakhrai-Rad H, etal., Hum Mol Genet 2000 Sep 1;9(14):2149-58. |
| 4. | Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo. | Farris W, etal., Proc Natl Acad Sci U S A 2003 Apr 1;100(7):4162-7. Epub 2003 Mar 12. |
| 5. | High-density haplotype structure and association testing of the insulin-degrading enzyme (IDE) gene with type 2 diabetes in 4,206 people. | Florez JC, etal., Diabetes. 2006 Jan;55(1):128-35. |
| 6. | Berberine Reduces Neurotoxicity Related to Nonalcoholic Steatohepatitis in Rats. | Ghareeb DA, etal., Evid Based Complement Alternat Med. 2015;2015:361847. doi: 10.1155/2015/361847. Epub 2015 Oct 20. |
| 7. | GOAs Human GO annotations | GOA_HUMAN data from the GO Consortium |
| 8. | Polymorphisms in the insulin-degrading enzyme gene are associated with type 2 diabetes in men from the NHLBI Framingham Heart Study. | Karamohamed S, etal., Diabetes. 2003 Jun;52(6):1562-7. |
| 9. | Insulin deprivation decreases insulin degrading enzyme levels in primary cultured cortical neurons and in the cerebral cortex of rats with streptozotocin-induced diabetes. | Kazkayasi I, etal., Pharmacol Rep. 2018 Aug;70(4):677-683. doi: 10.1016/j.pharep.2018.01.008. Epub 2018 Feb 1. |
| 10. | Treadmill Exercise Ameliorates Spatial Learning and Memory Deficits Through Improving the Clearance of Peripheral and Central Amyloid-Beta Levels. | Khodadadi D, etal., Neurochem Res. 2018 Aug;43(8):1561-1574. doi: 10.1007/s11064-018-2571-2. Epub 2018 Jun 11. |
| 11. | Effect of growth differentiation factor-15 secreted by human umbilical cord blood-derived mesenchymal stem cells on amyloid beta levels in in vitro and invivo models of Alzheimer's disease. | Kim DH, etal., Biochem Biophys Res Commun. 2018 Sep 14. pii: S0006-291X(18)31922-3. doi: 10.1016/j.bbrc.2018.09.012. |
| 12. | Genetic associations of type 2 diabetes with islet amyloid polypeptide processing and degrading pathways in asian populations. | Lam VK, etal., PLoS One. 2013 Jun 11;8(6):e62378. doi: 10.1371/journal.pone.0062378. Print 2013. |
| 13. | Multifunctional Compound AD-35 Improves Cognitive Impairment and Attenuates the Production of TNF-a and IL-1ß in an Aß25-35-induced Rat Model of Alzheimer's Disease. | Li L, etal., J Alzheimers Dis. 2017;56(4):1403-1417. doi: 10.3233/JAD-160587. |
| 14. | Insulin-degrading enzyme haplotypes affect insulin levels but not dementia risk. | Marlowe L, etal., Neurodegener Dis. 2006;3(6):320-6. |
| 15. | KEGG Annotation Import Pipeline | Pipeline to import KEGG annotations from KEGG into RGD |
| 16. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
| 17. | Insulin-degrading enzyme secretion from astrocytes is mediated by an autophagy-based unconventional secretory pathway in Alzheimer disease. | Son SM, etal., Autophagy. 2016 May 3;12(5):784-800. doi: 10.1080/15548627.2016.1159375. Epub 2016 Mar 10. |
| 18. | Serum Insulin Degrading Enzyme Level and Other Factors in Type 2 Diabetic Patients with Mild Cognitive Impairment. | Sun J, etal., Curr Alzheimer Res. 2016;13(12):1337-1345. |
| 19. | Neuroprotective mechanism of Kai Xin San: upregulation of hippocampal insulin-degrading enzyme protein expression and acceleration of amyloid-beta degradation. | Wang N, etal., Neural Regen Res. 2017 Apr;12(4):654-659. doi: 10.4103/1673-5374.205107. |
| 20. | Pioglitazone ameliorates Aß42 deposition in rats with diet-induced insulin resistance associated with AKT/GSK3ß activation. | Yang S, etal., Mol Med Rep. 2017 May;15(5):2588-2594. doi: 10.3892/mmr.2017.6342. Epub 2017 Mar 16. |
Additional References at PubMed
| PMID:758022 | PMID:1607078 | PMID:1733942 | PMID:1743072 | PMID:2293021 | PMID:3059494 | PMID:6401723 | PMID:7731996 | PMID:8051160 | PMID:8077210 | PMID:8425612 | PMID:9070242 |
| PMID:9231799 | PMID:9830016 | PMID:10684867 | PMID:11145591 | PMID:11809755 | PMID:12161276 | PMID:12477932 | PMID:12507914 | PMID:12716770 | PMID:12746301 | PMID:12850277 | PMID:14517947 |
| PMID:14702039 | PMID:14744259 | PMID:14755451 | PMID:14764804 | PMID:15024728 | PMID:15088150 | PMID:15181249 | PMID:15277398 | PMID:15277615 | PMID:15285718 | PMID:15489232 | PMID:15590928 |
| PMID:15718037 | PMID:15850385 | PMID:15858813 | PMID:15858821 | PMID:15911128 | PMID:16344560 | PMID:16385451 | PMID:16511862 | PMID:16574064 | PMID:16675064 | PMID:16876916 | PMID:16914266 |
| PMID:17051221 | PMID:17055432 | PMID:17143514 | PMID:17192785 | PMID:17244626 | PMID:17293876 | PMID:17463249 | PMID:17496198 | PMID:17579348 | PMID:17601350 | PMID:17613531 | PMID:17715127 |
| PMID:17804762 | PMID:17827400 | PMID:17913278 | PMID:17953957 | PMID:17964527 | PMID:17971426 | PMID:18212765 | PMID:18226493 | PMID:18411275 | PMID:18426861 | PMID:18448515 | PMID:18591388 |
| PMID:18602473 | PMID:18618095 | PMID:18621727 | PMID:18633108 | PMID:18719881 | PMID:18783335 | PMID:18813847 | PMID:18977241 | PMID:18984664 | PMID:18986166 | PMID:18996360 | PMID:19019493 |
| PMID:19053027 | PMID:19082521 | PMID:19139842 | PMID:19228808 | PMID:19239107 | PMID:19321446 | PMID:19383491 | PMID:19396426 | PMID:19453261 | PMID:19592050 | PMID:19592620 | PMID:19602701 |
| PMID:19606063 | PMID:19622614 | PMID:19741166 | PMID:19785409 | PMID:19794065 | PMID:19808678 | PMID:19808892 | PMID:19809796 | PMID:19862325 | PMID:19864391 | PMID:19864659 | PMID:19889475 |
| PMID:19896952 | PMID:19913121 | PMID:19933996 | PMID:19966293 | PMID:20033747 | PMID:20082125 | PMID:20098734 | PMID:20161779 | PMID:20178365 | PMID:20203524 | PMID:20360068 | PMID:20362553 |
| PMID:20364150 | PMID:20380468 | PMID:20384434 | PMID:20460429 | PMID:20490451 | PMID:20581827 | PMID:20628086 | PMID:20663017 | PMID:20703447 | PMID:20724036 | PMID:20816152 | PMID:20877624 |
| PMID:20880607 | PMID:20927120 | PMID:20959807 | PMID:20971110 | PMID:21098034 | PMID:21185309 | PMID:21232820 | PMID:21343292 | PMID:21731745 | PMID:21800051 | PMID:21873424 | PMID:21873635 |
| PMID:21903422 | PMID:21992747 | PMID:22036964 | PMID:22107728 | PMID:22267728 | PMID:22383525 | PMID:22502914 | PMID:22837378 | PMID:22863883 | PMID:23036584 | PMID:23416320 | PMID:23525105 |
| PMID:23597493 | PMID:23797320 | PMID:23922390 | PMID:24059301 | PMID:24355596 | PMID:24477584 | PMID:24509480 | PMID:24516642 | PMID:24778252 | PMID:24847884 | PMID:25105907 | PMID:25414272 |
| PMID:25544563 | PMID:25921289 | PMID:26186194 | PMID:26186340 | PMID:26344197 | PMID:26389662 | PMID:26496610 | PMID:26816005 | PMID:26968463 | PMID:27432908 | PMID:27499296 | PMID:27806189 |
| PMID:27880917 | PMID:27982586 | PMID:28514442 | PMID:28611215 | PMID:28675297 | PMID:29093479 | PMID:29273204 | PMID:29509190 | PMID:29596046 | PMID:29987050 | PMID:30021884 | PMID:30561431 |
| PMID:30649986 | PMID:30948266 | PMID:31056398 | PMID:31182584 | PMID:31409639 | PMID:31594818 | PMID:32235678 | PMID:32353859 | PMID:32416252 | PMID:32628020 | PMID:32687490 | PMID:32707033 |
| PMID:32807901 | PMID:32814053 | PMID:32857715 | PMID:32877691 | PMID:32963011 | PMID:33060197 | PMID:33631143 | PMID:33637726 | PMID:33865867 | PMID:33961781 | PMID:34349018 | PMID:34732716 |
| PMID:34800366 | PMID:35016035 | PMID:35163673 | PMID:35235311 | PMID:35236268 | PMID:35271311 | PMID:35509820 | PMID:35546756 | PMID:35552390 | PMID:35831314 | PMID:35944360 | PMID:36215168 |
| PMID:36551314 | PMID:36724073 | PMID:37059927 | PMID:37371470 | PMID:37466059 | PMID:37827155 | PMID:38113892 |
Genomics
Comparative Map Data
| IDE (Homo sapiens - human) |
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| Ide (Mus musculus - house mouse) |
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| Ide (Rattus norvegicus - Norway rat) |
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| Ide (Chinchilla lanigera - long-tailed chinchilla) |
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| IDE (Pan paniscus - bonobo/pygmy chimpanzee) |
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| IDE (Canis lupus familiaris - dog) |
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| Ide (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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| IDE (Sus scrofa - pig) |
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| IDE (Chlorocebus sabaeus - green monkey) |
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| Ide (Heterocephalus glaber - naked mole-rat) |
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Variants
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Variants in IDE
50 total Variants 
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