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Gene: IDE (insulin degrading enzyme) Homo sapiens
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Symbol: IDE
Name: insulin degrading enzyme
Description: Exhibits several functions, including ATP binding activity; insulin binding activity; and protein homodimerization activity. Involved in several processes, including amyloid-beta clearance by cellular catabolic process; peptide metabolic process; and protein catabolic process. Localizes to several cellular components, including the basolateral plasma membrane; external side of plasma membrane; and peroxisome. Implicated in type 2 diabetes mellitus. Biomarker of Alzheimer's disease and diabetic encephalopathy.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: Abeta-degrading protease; FLJ35968; insulin protease; insulin-degrading enzyme; insulinase; insulysin
Orthologs:
Mus musculus (house mouse) : Ide (insulin degrading enzyme)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ide (insulin degrading enzyme)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ide (insulin degrading enzyme)
Pan paniscus (bonobo/pygmy chimpanzee) : IDE (insulin degrading enzyme)
Canis lupus familiaris (dog) : IDE (insulin degrading enzyme)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ide (insulin degrading enzyme)
Sus scrofa (pig) : IDE (insulin degrading enzyme)
Chlorocebus sabaeus (African green monkey) : IDE (insulin degrading enzyme)
Heterocephalus glaber (naked mole-rat) : Ide (insulin degrading enzyme)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl1092,451,684 - 92,574,093 (-)EnsemblGRCh38hg38GRCh38
GRCh381092,451,684 - 92,574,095 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371094,211,441 - 94,333,852 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361094,203,580 - 94,323,832 (-)NCBINCBI36hg18NCBI36
Build 341094,204,018 - 94,323,813NCBI
Celera1087,952,861 - 88,075,347 (-)NCBI
Cytogenetic Map10q23.33NCBI
HuRef1087,837,258 - 87,960,004 (-)NCBIHuRef
CHM1_11094,493,176 - 94,615,858 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
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Molecular Pathway Annotations
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References - curated
References - uncurated

Genomics

Candidate Gene Status
Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
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Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on IDE
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 732801
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-03-24
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.