Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - TERM ANNOTATION REPORT

RGD ID: 2861
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ide
Name: insulin degrading enzyme
Acc ID: GO:0004222
Term: metalloendopeptidase activity
Definition: Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
Definition Source(s): GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ide IDA 1626705RGDatrial natriuretic peptide cleaved at the Ser25-Phe26 bond

 
Ide IMP 1626704RGD  
IdeenablesISOIDE (Homo sapiens)1624291RGD PMID:17051221 PMID:17613531

PMID:17051221 PMID:17613531
IdeenablesIEAUniProtKB:P14735 or ensembl:ENSP000002659861600115EnsemblGO_REF:0000107

GO_REF:0000107
IdeenablesIBAPANTHER:PTN000220551 or Ide (Rattus norvegicus) or SGD:S000004381 or UniProtKB:P147351600115GO_CentralGO_REF:0000033

GO_REF:0000033
IdeenablesIEAInterPro:IPR0014311600115InterProGO_REF:0000002

GO_REF:0000002
IdeenablesIEAPANTHER:PTHR43690:SF181600115TreeGrafterGO_REF:0000118

GO_REF:0000118
IdeenablesISSUniProtKB:P147351600115UniProtGO_REF:0000024

GO_REF:0000024
Go Back to source page   Continue to Ontology report