Cnnm2 (cyclin and CBS domain divalent metal cation transport mediator 2) - Rat Genome Database

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Gene: Cnnm2 (cyclin and CBS domain divalent metal cation transport mediator 2) Rattus norvegicus
Analyze
Symbol: Cnnm2
Name: cyclin and CBS domain divalent metal cation transport mediator 2
RGD ID: 1308162
Description: Predicted to enable ATP binding activity and magnesium ion transmembrane transporter activity. Predicted to be involved in magnesium ion homeostasis. Predicted to act upstream of or within magnesium ion transmembrane transport. Predicted to be located in basolateral plasma membrane. Predicted to be active in intracellular membrane-bounded organelle and plasma membrane. Human ortholog(s) of this gene implicated in renal hypomagnesemia 6. Orthologous to human CNNM2 (cyclin and CBS domain divalent metal cation transport mediator 2); INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: ancient conserved domain-containing protein 2; cyclin M2; cyclin-M2; LOC294014; metal transporter CNNM2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21245,643,682 - 245,769,542 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1245,643,768 - 245,763,286 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1253,771,061 - 253,889,451 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01260,465,253 - 260,582,677 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01253,113,558 - 253,232,106 (+)NCBIRnor_WKY
Rnor_6.01266,530,421 - 266,651,292 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1266,530,477 - 266,649,398 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01273,961,251 - 274,081,226 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41252,077,259 - 252,195,971 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11252,340,413 - 252,459,140 (+)NCBI
Celera1241,415,759 - 241,534,698 (+)NCBICelera
Cytogenetic Map1q54NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:21397062   PMID:24706765  


Genomics

Comparative Map Data
Cnnm2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21245,643,682 - 245,769,542 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1245,643,768 - 245,763,286 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1253,771,061 - 253,889,451 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01260,465,253 - 260,582,677 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01253,113,558 - 253,232,106 (+)NCBIRnor_WKY
Rnor_6.01266,530,421 - 266,651,292 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1266,530,477 - 266,649,398 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01273,961,251 - 274,081,226 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41252,077,259 - 252,195,971 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11252,340,413 - 252,459,140 (+)NCBI
Celera1241,415,759 - 241,534,698 (+)NCBICelera
Cytogenetic Map1q54NCBI
CNNM2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810102,918,294 - 103,090,222 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl10102,918,294 - 103,090,222 (+)EnsemblGRCh38hg38GRCh38
GRCh3710104,678,051 - 104,849,979 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3610104,668,104 - 104,828,231 (+)NCBINCBI36Build 36hg18NCBI36
Celera1098,418,329 - 98,578,461 (+)NCBICelera
Cytogenetic Map10q24.32NCBI
HuRef1098,312,430 - 98,472,855 (+)NCBIHuRef
CHM1_110104,960,909 - 105,121,224 (+)NCBICHM1_1
T2T-CHM13v2.010103,804,071 - 103,976,463 (+)NCBIT2T-CHM13v2.0
Cnnm2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391946,745,273 - 46,867,019 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1946,750,035 - 46,868,631 (+)EnsemblGRCm39 Ensembl
GRCm381946,756,834 - 46,878,580 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1946,761,596 - 46,880,192 (+)EnsemblGRCm38mm10GRCm38
MGSCv371946,836,099 - 46,953,070 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361946,815,608 - 46,931,891 (+)NCBIMGSCv36mm8
Celera1947,530,523 - 47,648,072 (+)NCBICelera
Cytogenetic Map19C3NCBI
cM Map1938.97NCBI
Cnnm2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554857,403,549 - 7,545,987 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554857,399,085 - 7,546,176 (-)NCBIChiLan1.0ChiLan1.0
CNNM2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.110102,981,911 - 103,138,886 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl10102,982,148 - 103,137,580 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01099,519,187 - 99,687,138 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
CNNM2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12815,366,035 - 15,515,261 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2815,366,601 - 15,514,886 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2815,538,133 - 15,686,874 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02815,841,070 - 15,990,412 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2815,788,533 - 15,990,025 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12815,384,679 - 15,540,273 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02815,423,855 - 15,571,651 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02815,556,906 - 15,706,273 (+)NCBIUU_Cfam_GSD_1.0
Cnnm2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721331,295,088 - 31,433,123 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366002,904,410 - 3,036,132 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049366002,898,321 - 3,037,414 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CNNM2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14113,889,950 - 114,053,352 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114113,888,970 - 114,060,369 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214123,856,499 - 124,030,358 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CNNM2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1995,956,224 - 96,130,714 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl995,955,654 - 96,122,976 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604857,068,214 - 57,244,730 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cnnm2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248312,219,818 - 2,365,114 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248312,219,764 - 2,370,005 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cnnm2
438 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:276
Count of miRNA genes:183
Interacting mature miRNAs:213
Transcripts:ENSRNOT00000054699
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1150700142252085212Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1150700247252085048Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1156677124256448636Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1176426412257976495Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1177227632256448636Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1177227632256448636Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1179567751260522016Rat
1358898Bp255Blood pressure QTL 2553.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1191019702246062233Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1195804352257091168Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1199050459259647894Rat
2293694Bss38Bone structure and strength QTL 387.050.0001femur strength trait (VT:0010010)femur stiffness (CMO:0001674)1201554356246554356Rat
7394701Uae46Urinary albumin excretion QTL 463.60.0056urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1201554356246554356Rat
2300175Bmd40Bone mineral density QTL 4015.40.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)1201554356246554356Rat
2293655Bss36Bone structure and strength QTL 3610.660.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1201554356246554356Rat
2293674Bss39Bone structure and strength QTL 397.10.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)1201554356246554356Rat
10059587Bw173Body weight QTL 1733.230.025body mass (VT:0001259)body weight (CMO:0000012)1202069611247069611Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1206081677251081677Rat
1357399Bw45Body weight QTL 453.05body mass (VT:0001259)body mass index (BMI) (CMO:0000105)1206329708251329708Rat
1357404Bw42Body weight QTL 424.490.0001body mass (VT:0001259)body weight (CMO:0000012)1206329708251329708Rat
1358890Bp259Blood pressure QTL 2593.06arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1210702053260522016Rat
724538Kidm1Kidney mass QTL 13.2kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1213707201252085212Rat
734768Niddm59Non-insulin dependent diabetes mellitus QTL 59body mass (VT:0001259)body weight (CMO:0000012)1213843987258843987Rat
70211Niddm24Non-insulin dependent diabetes mellitus QTL 243.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1214647894259647894Rat
1549910Bw54Body weight QTL 540.05body mass (VT:0001259)body weight (CMO:0000012)1214647894259647894Rat
61327Eae7Experimental allergic encephalomyelitis QTL 75.6body mass (VT:0001259)change in body weight (CMO:0002045)1216255568260522016Rat
2302040Pia35Pristane induced arthritis QTL 353.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1216255568260522016Rat
1598821Rf55Renal function QTL 556.3renal blood flow trait (VT:2000006)ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)1218748008257976495Rat
61400Niddm1Non-insulin dependent diabetes mellitus QTL 111blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1218753689245907899Rat
724533Rf51Renal function QTL 515.30.0002kidney plasma flow trait (VT:0005524)renal plasma flow (CMO:0001914)1218753816256448513Rat
731175Uae20Urinary albumin excretion QTL 203.50.0018urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1221264111259647894Rat
10053715Scort24Serum corticosterone level QTL 242.130.0088blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1221414816260522016Rat
724552Glom2Glomerulus QTL 23.30.0001kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)1222363780260522016Rat
1600392Bw123Body weight QTL 1230.001body mass (VT:0001259)body weight (CMO:0000012)1223201027260522016Rat
734767Niddm57Non-insulin dependent diabetes mellitus QTL 57body mass (VT:0001259)body weight (CMO:0000012)1224054293260122809Rat
631843Bw116Body weight QTL 1164.10.016abdominal adipose amount (VT:1000220)abdominal fat pad weight (CMO:0000088)1224054293260122809Rat
734769Niddm58Non-insulin dependent diabetes mellitus QTL 58body mass (VT:0001259)body weight (CMO:0000012)1224569538260122809Rat
631215Stl8Serum triglyceride level QTL 89.270.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1225126575260522016Rat
1300108Rf8Renal function QTL 83.75renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)1228581588259647894Rat
2316896Gluco57Glucose level QTL 577.2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1228985440245907899Rat
1581544Rf52Renal function QTL 520.05urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)1232156370259647894Rat
631669Iddm9Insulin dependent diabetes mellitus QTL 92.80.039blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1233190394258625266Rat
631536Lnnr2Liver neoplastic nodule remodeling QTL 22.90.0005liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)1233948574260522016Rat
631690Scl5Serum cholesterol level QTL 52.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1236125214260522016Rat
631836Stl31Serum triglyceride level QTL 314.640.00000487blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1237147813260522016Rat
631837Niddm35Non-insulin dependent diabetes mellitus QTL 350.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1238699859259647894Rat

Markers in Region
D1Rat83  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21245,700,955 - 245,701,099 (+)MAPPERmRatBN7.2
Rnor_6.01266,587,077 - 266,587,220NCBIRnor6.0
Rnor_5.01274,017,004 - 274,017,147UniSTSRnor5.0
RGSC_v3.41252,133,646 - 252,133,789UniSTSRGSC3.4
RGSC_v3.41252,133,623 - 252,133,935RGDRGSC3.4
RGSC_v3.11252,396,818 - 252,396,961RGD
Celera1241,472,435 - 241,472,578UniSTS
RH 3.4 Map11622.5UniSTS
RH 3.4 Map11622.5RGD
RH 2.0 Map11228.9999RGD
SHRSP x BN Map1139.09RGD
FHH x ACI Map1129.1899RGD
Cytogenetic Map1q54UniSTS
AW048635  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21245,763,129 - 245,763,258 (+)MAPPERmRatBN7.2
Rnor_6.01266,649,242 - 266,649,370NCBIRnor6.0
Rnor_5.01274,079,169 - 274,079,297UniSTSRnor5.0
RGSC_v3.41252,195,811 - 252,195,939UniSTSRGSC3.4
Celera1241,534,538 - 241,534,666UniSTS
Cytogenetic Map1q54UniSTS
MARC_7523-7524:992008440:1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21245,761,912 - 245,762,575 (+)MAPPERmRatBN7.2
Rnor_6.01266,648,025 - 266,648,687NCBIRnor6.0
Rnor_5.01274,077,952 - 274,078,614UniSTSRnor5.0
RGSC_v3.41252,194,594 - 252,195,256UniSTSRGSC3.4
Celera1241,533,321 - 241,533,983UniSTS
Cytogenetic Map1q54UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 48 27 4
Low 2 43 57 41 19 41 8 10 26 8 37 11 8
Below cutoff 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000054699   ⟹   ENSRNOP00000051583
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1245,643,768 - 245,763,286 (+)Ensembl
Rnor_6.0 Ensembl1266,530,477 - 266,649,398 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000110289   ⟹   ENSRNOP00000085266
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1245,643,768 - 245,763,286 (+)Ensembl
RefSeq Acc Id: NM_001011942   ⟹   NP_001011942
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21245,643,768 - 245,763,290 (+)NCBI
Rnor_6.01266,530,477 - 266,649,402 (+)NCBI
Rnor_5.01273,961,251 - 274,081,226 (+)NCBI
RGSC_v3.41252,077,259 - 252,195,971 (+)RGD
Celera1241,415,759 - 241,534,698 (+)RGD
Sequence:
RefSeq Acc Id: XM_006231471   ⟹   XP_006231533
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21245,643,877 - 245,769,542 (+)NCBI
Rnor_6.01266,530,586 - 266,651,292 (+)NCBI
Rnor_5.01273,961,251 - 274,081,226 (+)NCBI
Sequence:
RefSeq Acc Id: XR_005504350
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21245,643,682 - 245,743,572 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001011942 (Get FASTA)   NCBI Sequence Viewer  
  XP_006231533 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH85930 (Get FASTA)   NCBI Sequence Viewer  
  Q5U2P1 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001011942   ⟸   NM_001011942
- UniProtKB: Q5U2P1 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006231533   ⟸   XM_006231471
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZZS9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000051583   ⟸   ENSRNOT00000054699
RefSeq Acc Id: ENSRNOP00000085266   ⟸   ENSRNOT00000110289
Protein Domains
CBS   CNNM transmembrane

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5U2P1-F1-model_v2 AlphaFold Q5U2P1 1-875 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690974
Promoter ID:EPDNEW_R1498
Type:multiple initiation site
Name:Cnnm2_1
Description:cyclin and CBS domain divalent metal cation transport mediator2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01266,530,462 - 266,530,522EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308162 AgrOrtholog
BioCyc Gene G2FUF-55497 BioCyc
Ensembl Genes ENSRNOG00000020113 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000051583 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000085266 ENTREZGENE
  ENSRNOP00000085266.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000054699 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000110289 ENTREZGENE
  ENSRNOT00000110289.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.10.580.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7110800 IMAGE-MGC_LOAD
InterPro ACDP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CBS_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CBS_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  cNMP-bd-like UniProtKB/TrEMBL
  CNNM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion_transp-like_CBS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RmlC-like_jellyroll UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:294014 UniProtKB/Swiss-Prot
MGC_CLONE MGC:94883 IMAGE-MGC_LOAD
NCBI Gene 294014 ENTREZGENE
PANTHER PTHR12064 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam CBS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DUF21 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cnnm2 PhenoGen
PROSITE CBS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CNNM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF51206 UniProtKB/TrEMBL
  SSF54631 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZZS9 ENTREZGENE, UniProtKB/TrEMBL
  CNNM2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-08-13 Cnnm2  cyclin and CBS domain divalent metal cation transport mediator 2  Cnnm2  cyclin M2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Cnnm2  cyclin M2  Cnnm2_predicted  cyclin M2 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Cnnm2_predicted  cyclin M2 (predicted)      Symbol and Name status set to approved 70820 APPROVED