Btrc (beta-transducin repeat containing E3 ubiquitin protein ligase) - Rat Genome Database

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Gene: Btrc (beta-transducin repeat containing E3 ubiquitin protein ligase) Rattus norvegicus
Analyze
Symbol: Btrc
Name: beta-transducin repeat containing E3 ubiquitin protein ligase
RGD ID: 1359721
Description: Predicted to enable several functions, including beta-catenin binding activity; ubiquitin ligase activator activity; and ubiquitin ligase-substrate adaptor activity. Predicted to contribute to ubiquitin-protein transferase activity. Predicted to be involved in several processes, including positive regulation of nitrogen compound metabolic process; protein destabilization; and protein modification process. Predicted to act upstream of or within several processes, including SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; mammary gland epithelium development; and protein K48-linked ubiquitination. Predicted to be located in cytoplasm and nucleus. Predicted to be part of SCF ubiquitin ligase complex. Orthologous to human BTRC (beta-transducin repeat containing E3 ubiquitin protein ligase); PARTICIPATES IN Hedgehog signaling pathway; nuclear factor kappa B signaling pathway; nuclear factor, erythroid 2 like 2 signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; gentamycin.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: beta-transducin repeat containing; beta-TrCP1; F-box/WD repeat-containing protein 1A; MGC105884
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21244,210,299 - 244,380,126 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1244,210,314 - 244,376,721 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1252,352,104 - 252,517,594 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01259,055,485 - 259,220,754 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01251,701,700 - 251,867,236 (+)NCBIRnor_WKY
Rnor_6.01265,100,094 - 265,270,263 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1265,157,379 - 265,269,837 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01272,540,431 - 272,709,172 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41250,528,730 - 250,693,952 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11250,789,742 - 250,954,519 (+)NCBI
Celera1240,018,088 - 240,184,606 (+)NCBICelera
Cytogenetic Map1q54NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Hedgehog signaling update. Cohen MM, Am J Med Genet A. 2010 Aug;152A(8):1875-914. doi: 10.1002/ajmg.a.32909.
2. Structural and functional characterization of Nrf2 degradation by glycogen synthase kinase 3/beta-TrCP. Cuadrado A Free Radic Biol Med. 2015 Nov;88(Pt B):147-57. doi: 10.1016/j.freeradbiomed.2015.04.029. Epub 2015 Apr 30.
3. The Nrf2 regulatory network provides an interface between redox and intermediary metabolism. Hayes JD and Dinkova-Kostova AT, Trends Biochem Sci. 2014 Apr;39(4):199-218. doi: 10.1016/j.tibs.2014.02.002. Epub 2014 Mar 16.
4. Wnt signalling and its impact on development and cancer. Klaus A and Birchmeier W, Nat Rev Cancer. 2008 May;8(5):387-98.
5. Expanding role of ubiquitination in NF-kappaB signaling. Liu S and Chen ZJ, Cell Res. 2011 Jan;21(1):6-21. Epub 2010 Dec 7.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. GOA pipeline RGD automated data pipeline
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
11. The role of -transducin repeat-containing protein ([beta]-TrCP) in the regulation of NF-[kappa]B in vascular smooth muscle cells. Wang X, etal., Arterioscler Thromb Vasc Biol 2004 Jan;24(1):85-90. Epub 2003 Oct 30.
Additional References at PubMed
PMID:10228155   PMID:11158290   PMID:12791266   PMID:12820959   PMID:12843402   PMID:14673179   PMID:15340078   PMID:15448698   PMID:15917222   PMID:16885022   PMID:18354482   PMID:18723513  
PMID:18782782   PMID:18929646   PMID:19028597   PMID:19103752   PMID:19966869   PMID:21258371   PMID:21873635   PMID:21911472   PMID:23640883   PMID:23850969   PMID:29593216  


Genomics

Comparative Map Data
Btrc
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21244,210,299 - 244,380,126 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1244,210,314 - 244,376,721 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1252,352,104 - 252,517,594 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01259,055,485 - 259,220,754 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01251,701,700 - 251,867,236 (+)NCBIRnor_WKY
Rnor_6.01265,100,094 - 265,270,263 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1265,157,379 - 265,269,837 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01272,540,431 - 272,709,172 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41250,528,730 - 250,693,952 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11250,789,742 - 250,954,519 (+)NCBI
Celera1240,018,088 - 240,184,606 (+)NCBICelera
Cytogenetic Map1q54NCBI
BTRC
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810101,354,048 - 101,557,313 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl10101,354,033 - 101,557,321 (+)EnsemblGRCh38hg38GRCh38
GRCh3710103,113,922 - 103,317,070 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3610103,103,815 - 103,307,060 (+)NCBINCBI36Build 36hg18NCBI36
Build 3410103,103,814 - 103,307,058NCBI
Celera1096,852,547 - 97,055,847 (+)NCBICelera
Cytogenetic Map10q24.32NCBI
HuRef1096,743,700 - 96,947,675 (+)NCBIHuRef
CHM1_110103,397,663 - 103,600,757 (+)NCBICHM1_1
T2T-CHM13v2.010102,238,134 - 102,441,353 (+)NCBIT2T-CHM13v2.0
Btrc
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391945,352,119 - 45,521,782 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1945,352,173 - 45,518,452 (+)EnsemblGRCm39 Ensembl
GRCm381945,363,688 - 45,533,343 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1945,363,734 - 45,530,013 (+)EnsemblGRCm38mm10GRCm38
MGSCv371945,438,224 - 45,607,833 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361945,409,208 - 45,583,324 (+)NCBIMGSCv36mm8
Celera1946,131,196 - 46,300,930 (+)NCBICelera
Cytogenetic Map19C3NCBI
Btrc
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554858,724,380 - 8,837,741 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554858,724,375 - 8,846,647 (-)NCBIChiLan1.0ChiLan1.0
BTRC
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.110101,431,318 - 101,632,496 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl10101,431,318 - 101,632,496 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01097,958,527 - 98,159,550 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
BTRC
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12813,988,408 - 14,173,223 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2813,988,432 - 14,169,581 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2814,157,392 - 14,341,955 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02814,456,360 - 14,641,386 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2814,456,356 - 14,641,377 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12814,001,856 - 14,186,114 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02814,043,050 - 14,227,655 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02814,175,408 - 14,359,768 (+)NCBIUU_Cfam_GSD_1.0
Btrc
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721332,610,766 - 32,794,483 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366004,213,956 - 4,397,987 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049366004,215,219 - 4,424,498 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BTRC
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14112,398,868 - 112,588,037 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114112,398,764 - 112,588,041 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214122,141,884 - 122,331,382 (+)NCBISscrofa10.2Sscrofa10.2susScr3
BTRC
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1994,333,046 - 94,581,327 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl994,376,055 - 94,574,678 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604855,451,723 - 55,657,317 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Btrc
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624831868,563 - 1,060,248 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624831868,417 - 1,065,591 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Btrc
338 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:62
Count of miRNA genes:50
Interacting mature miRNAs:62
Transcripts:ENSRNOT00000022426
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1150700142252085212Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1150700247252085048Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1156677124256448636Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1176426412257976495Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1177227632256448636Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1177227632256448636Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1179567751260522016Rat
1358898Bp255Blood pressure QTL 2553.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1191019702246062233Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1195804352257091168Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1199050459259647894Rat
2293694Bss38Bone structure and strength QTL 387.050.0001femur strength trait (VT:0010010)femur stiffness (CMO:0001674)1201554356246554356Rat
7394701Uae46Urinary albumin excretion QTL 463.60.0056urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1201554356246554356Rat
2300175Bmd40Bone mineral density QTL 4015.40.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)1201554356246554356Rat
2293655Bss36Bone structure and strength QTL 3610.660.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1201554356246554356Rat
2293674Bss39Bone structure and strength QTL 397.10.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)1201554356246554356Rat
10059587Bw173Body weight QTL 1733.230.025body mass (VT:0001259)body weight (CMO:0000012)1202069611247069611Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1206081677251081677Rat
1357399Bw45Body weight QTL 453.05body mass (VT:0001259)body mass index (BMI) (CMO:0000105)1206329708251329708Rat
1357404Bw42Body weight QTL 424.490.0001body mass (VT:0001259)body weight (CMO:0000012)1206329708251329708Rat
1358890Bp259Blood pressure QTL 2593.06arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1210702053260522016Rat
724538Kidm1Kidney mass QTL 13.2kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1213707201252085212Rat
734768Niddm59Non-insulin dependent diabetes mellitus QTL 59body mass (VT:0001259)body weight (CMO:0000012)1213843987258843987Rat
70211Niddm24Non-insulin dependent diabetes mellitus QTL 243.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1214647894259647894Rat
1549910Bw54Body weight QTL 540.05body mass (VT:0001259)body weight (CMO:0000012)1214647894259647894Rat
61327Eae7Experimental allergic encephalomyelitis QTL 75.6body mass (VT:0001259)change in body weight (CMO:0002045)1216255568260522016Rat
2302040Pia35Pristane induced arthritis QTL 353.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1216255568260522016Rat
1598821Rf55Renal function QTL 556.3renal blood flow trait (VT:2000006)ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)1218748008257976495Rat
61400Niddm1Non-insulin dependent diabetes mellitus QTL 111blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1218753689245907899Rat
724533Rf51Renal function QTL 515.30.0002kidney plasma flow trait (VT:0005524)renal plasma flow (CMO:0001914)1218753816256448513Rat
731175Uae20Urinary albumin excretion QTL 203.50.0018urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1221264111259647894Rat
10053715Scort24Serum corticosterone level QTL 242.130.0088blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1221414816260522016Rat
724552Glom2Glomerulus QTL 23.30.0001kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)1222363780260522016Rat
1600392Bw123Body weight QTL 1230.001body mass (VT:0001259)body weight (CMO:0000012)1223201027260522016Rat
734767Niddm57Non-insulin dependent diabetes mellitus QTL 57body mass (VT:0001259)body weight (CMO:0000012)1224054293260122809Rat
631843Bw116Body weight QTL 1164.10.016abdominal adipose amount (VT:1000220)abdominal fat pad weight (CMO:0000088)1224054293260122809Rat
734769Niddm58Non-insulin dependent diabetes mellitus QTL 58body mass (VT:0001259)body weight (CMO:0000012)1224569538260122809Rat
631215Stl8Serum triglyceride level QTL 89.270.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1225126575260522016Rat
1300108Rf8Renal function QTL 83.75renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)1228581588259647894Rat
2316896Gluco57Glucose level QTL 577.2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1228985440245907899Rat
1581544Rf52Renal function QTL 520.05urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)1232156370259647894Rat
631669Iddm9Insulin dependent diabetes mellitus QTL 92.80.039blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1233190394258625266Rat
631536Lnnr2Liver neoplastic nodule remodeling QTL 22.90.0005liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)1233948574260522016Rat
631690Scl5Serum cholesterol level QTL 52.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1236125214260522016Rat
631836Stl31Serum triglyceride level QTL 314.640.00000487blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1237147813260522016Rat
631837Niddm35Non-insulin dependent diabetes mellitus QTL 350.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1238699859259647894Rat

Markers in Region
D1Got234  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21244,349,015 - 244,349,177 (+)MAPPERmRatBN7.2
Rnor_6.01265,239,157 - 265,239,318NCBIRnor6.0
Rnor_5.01272,678,645 - 272,678,806UniSTSRnor5.0
RGSC_v3.41250,667,175 - 250,667,337RGDRGSC3.4
RGSC_v3.41250,667,176 - 250,667,337UniSTSRGSC3.4
RGSC_v3.11250,927,744 - 250,927,906RGD
Celera1240,157,833 - 240,157,996UniSTS
Cytogenetic Map1q54UniSTS
D1Got434  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21244,349,016 - 244,349,196 (+)MAPPERmRatBN7.2
Rnor_6.01265,239,158 - 265,239,337NCBIRnor6.0
Rnor_5.01272,678,646 - 272,678,825UniSTSRnor5.0
RGSC_v3.41250,667,177 - 250,667,356UniSTSRGSC3.4
Celera1240,157,834 - 240,158,015UniSTS
Cytogenetic Map1q54UniSTS
BF412449  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21244,326,914 - 244,327,059 (+)MAPPERmRatBN7.2
Rnor_6.01265,217,060 - 265,217,204NCBIRnor6.0
Rnor_5.01272,656,548 - 272,656,692UniSTSRnor5.0
RGSC_v3.41250,645,079 - 250,645,223UniSTSRGSC3.4
Celera1240,135,582 - 240,135,726UniSTS
RH 3.4 Map11623.01UniSTS
Cytogenetic Map1q54UniSTS
RH138908  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21244,233,983 - 244,234,181 (+)MAPPERmRatBN7.2
Rnor_6.01265,125,007 - 265,125,204NCBIRnor6.0
Rnor_5.01272,564,424 - 272,564,621UniSTSRnor5.0
RGSC_v3.41250,552,425 - 250,552,622UniSTSRGSC3.4
Celera1240,042,426 - 240,042,623UniSTS
RH 3.4 Map11622.91UniSTS
Cytogenetic Map1q54UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 26 28 22 6 22 2 74 20 39 3
Low 3 17 29 19 13 19 8 9 15 2 8 8
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001007148 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006231529 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006231530 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006231531 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006231535 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006231536 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006231537 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006231538 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006231539 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006231541 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006231543 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017589454 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017589455 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039084578 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039084594 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039084604 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039084622 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039084629 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039084633 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039084634 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039084638 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039084642 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC097970 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC111315 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC085125 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB584165 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473986 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EV771066 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232628 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000054 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000022426   ⟹   ENSRNOP00000022426
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1244,210,364 - 244,375,790 (+)Ensembl
Rnor_6.0 Ensembl1265,157,379 - 265,269,837 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000093843   ⟹   ENSRNOP00000089782
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1244,210,386 - 244,375,787 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000105194   ⟹   ENSRNOP00000091578
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1244,235,447 - 244,375,789 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000105215   ⟹   ENSRNOP00000081511
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1244,210,364 - 244,376,361 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000105391   ⟹   ENSRNOP00000093279
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1244,210,314 - 244,375,789 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000105576   ⟹   ENSRNOP00000082092
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1244,210,370 - 244,375,787 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000107722   ⟹   ENSRNOP00000079127
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1244,249,369 - 244,376,361 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000117570   ⟹   ENSRNOP00000083705
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1244,346,838 - 244,376,721 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000118041   ⟹   ENSRNOP00000078424
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1244,210,364 - 244,376,361 (+)Ensembl
RefSeq Acc Id: NM_001007148   ⟹   NP_001007149
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21244,210,309 - 244,375,790 (+)NCBI
Rnor_6.01265,100,138 - 265,265,927 (+)NCBI
Rnor_5.01272,540,431 - 272,709,172 (+)NCBI
RGSC_v3.41250,528,730 - 250,693,952 (+)RGD
Celera1240,018,088 - 240,184,606 (+)RGD
Sequence:
RefSeq Acc Id: XM_006231530   ⟹   XP_006231592
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21244,210,299 - 244,380,126 (+)NCBI
Rnor_6.01265,100,096 - 265,270,263 (+)NCBI
Rnor_5.01272,540,431 - 272,709,172 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006231531   ⟹   XP_006231593
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21244,210,299 - 244,380,126 (+)NCBI
Rnor_6.01265,100,094 - 265,270,263 (+)NCBI
Rnor_5.01272,540,431 - 272,709,172 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006231536   ⟹   XP_006231598
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21244,210,299 - 244,375,790 (+)NCBI
Rnor_6.01265,100,096 - 265,270,263 (+)NCBI
Rnor_5.01272,540,431 - 272,709,172 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006231538   ⟹   XP_006231600
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21244,210,299 - 244,375,790 (+)NCBI
Rnor_6.01265,100,097 - 265,270,263 (+)NCBI
Rnor_5.01272,540,431 - 272,709,172 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006231539   ⟹   XP_006231601
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21244,288,527 - 244,380,126 (+)NCBI
Rnor_6.01265,177,950 - 265,270,263 (+)NCBI
Rnor_5.01272,540,431 - 272,709,172 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006231541   ⟹   XP_006231603
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21244,292,625 - 244,380,126 (+)NCBI
Rnor_6.01265,182,661 - 265,270,263 (+)NCBI
Rnor_5.01272,540,431 - 272,709,172 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017589455   ⟹   XP_017444944
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21244,251,802 - 244,380,126 (+)NCBI
Rnor_6.01265,140,897 - 265,270,263 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039084578   ⟹   XP_038940506
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21244,210,355 - 244,380,126 (+)NCBI
RefSeq Acc Id: XM_039084594   ⟹   XP_038940522
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21244,212,510 - 244,380,126 (+)NCBI
RefSeq Acc Id: XM_039084604   ⟹   XP_038940532
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21244,210,299 - 244,380,126 (+)NCBI
RefSeq Acc Id: XM_039084622   ⟹   XP_038940550
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21244,251,802 - 244,380,126 (+)NCBI
RefSeq Acc Id: XM_039084629   ⟹   XP_038940557
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21244,210,299 - 244,380,126 (+)NCBI
RefSeq Acc Id: XM_039084633   ⟹   XP_038940561
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21244,295,163 - 244,380,126 (+)NCBI
RefSeq Acc Id: XM_039084634   ⟹   XP_038940562
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21244,210,301 - 244,380,126 (+)NCBI
RefSeq Acc Id: XM_039084638   ⟹   XP_038940566
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21244,210,757 - 244,380,126 (+)NCBI
RefSeq Acc Id: XM_039084642   ⟹   XP_038940570
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21244,210,537 - 244,380,126 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_001007149   ⟸   NM_001007148
- UniProtKB: Q5U4E5 (UniProtKB/TrEMBL),   A0A8I6G2R1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006231593   ⟸   XM_006231531
- Peptide Label: isoform X3
- UniProtKB: A0A8I5ZRU0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006231598   ⟸   XM_006231536
- Peptide Label: isoform X5
- UniProtKB: A0A8I6AFI6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006231592   ⟸   XM_006231530
- Peptide Label: isoform X1
- UniProtKB: F1LMH8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006231600   ⟸   XM_006231538
- Peptide Label: isoform X7
- UniProtKB: A0A8I6GHM9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006231601   ⟸   XM_006231539
- Peptide Label: isoform X12
- UniProtKB: Q5U4E5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006231603   ⟸   XM_006231541
- Peptide Label: isoform X12
- UniProtKB: Q5U4E5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017444944   ⟸   XM_017589455
- Peptide Label: isoform X4
- UniProtKB: F1LMH8 (UniProtKB/TrEMBL),   A0A8I5ZX54 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000022426   ⟸   ENSRNOT00000022426
RefSeq Acc Id: XP_038940557   ⟸   XM_039084629
- Peptide Label: isoform X9
RefSeq Acc Id: XP_038940532   ⟸   XM_039084604
- Peptide Label: isoform X6
RefSeq Acc Id: XP_038940562   ⟸   XM_039084634
- Peptide Label: isoform X11
RefSeq Acc Id: XP_038940506   ⟸   XM_039084578
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038940570   ⟸   XM_039084642
- Peptide Label: isoform X12
- UniProtKB: Q5U4E5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038940566   ⟸   XM_039084638
- Peptide Label: isoform X12
- UniProtKB: Q5U4E5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038940522   ⟸   XM_039084594
- Peptide Label: isoform X4
- UniProtKB: A0A8I5ZX54 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038940550   ⟸   XM_039084622
- Peptide Label: isoform X8
RefSeq Acc Id: XP_038940561   ⟸   XM_039084633
- Peptide Label: isoform X10
RefSeq Acc Id: ENSRNOP00000081511   ⟸   ENSRNOT00000105215
RefSeq Acc Id: ENSRNOP00000091578   ⟸   ENSRNOT00000105194
RefSeq Acc Id: ENSRNOP00000078424   ⟸   ENSRNOT00000118041
RefSeq Acc Id: ENSRNOP00000083705   ⟸   ENSRNOT00000117570
RefSeq Acc Id: ENSRNOP00000089782   ⟸   ENSRNOT00000093843
RefSeq Acc Id: ENSRNOP00000079127   ⟸   ENSRNOT00000107722
RefSeq Acc Id: ENSRNOP00000082092   ⟸   ENSRNOT00000105576
RefSeq Acc Id: ENSRNOP00000093279   ⟸   ENSRNOT00000105391
Protein Domains
F-box

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LMH8-F1-model_v2 AlphaFold F1LMH8 1-587 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1359721 AgrOrtholog
BioCyc Gene G2FUF-55548 BioCyc
Ensembl Genes ENSRNOG00000016280 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000022426 ENTREZGENE
  ENSRNOP00000022426.6 UniProtKB/TrEMBL
  ENSRNOP00000078424 ENTREZGENE
  ENSRNOP00000078424.1 UniProtKB/TrEMBL
  ENSRNOP00000079127.1 UniProtKB/TrEMBL
  ENSRNOP00000081511 ENTREZGENE
  ENSRNOP00000081511.1 UniProtKB/TrEMBL
  ENSRNOP00000082092 ENTREZGENE
  ENSRNOP00000082092.1 UniProtKB/TrEMBL
  ENSRNOP00000083705 ENTREZGENE
  ENSRNOP00000083705.1 UniProtKB/TrEMBL
  ENSRNOP00000089782 ENTREZGENE
  ENSRNOP00000089782.1 UniProtKB/TrEMBL
  ENSRNOP00000091578.1 UniProtKB/TrEMBL
  ENSRNOP00000093279 ENTREZGENE
  ENSRNOP00000093279.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000022426 ENTREZGENE
  ENSRNOT00000022426.8 UniProtKB/TrEMBL
  ENSRNOT00000093843 ENTREZGENE
  ENSRNOT00000093843.1 UniProtKB/TrEMBL
  ENSRNOT00000105194.1 UniProtKB/TrEMBL
  ENSRNOT00000105215 ENTREZGENE
  ENSRNOT00000105215.1 UniProtKB/TrEMBL
  ENSRNOT00000105391 ENTREZGENE
  ENSRNOT00000105391.1 UniProtKB/TrEMBL
  ENSRNOT00000105576 ENTREZGENE
  ENSRNOT00000105576.1 UniProtKB/TrEMBL
  ENSRNOT00000107722.1 UniProtKB/TrEMBL
  ENSRNOT00000117570 ENTREZGENE
  ENSRNOT00000117570.1 UniProtKB/TrEMBL
  ENSRNOT00000118041 ENTREZGENE
  ENSRNOT00000118041.1 UniProtKB/TrEMBL
Gene3D-CATH 2.130.10.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7131883 IMAGE-MGC_LOAD
InterPro Beta-TrCP_D UniProtKB/TrEMBL
  F-box_dom_cyclin-like UniProtKB/TrEMBL
  F-box_dom_like UniProtKB/TrEMBL
  G-protein_beta_WD-40_rep UniProtKB/TrEMBL
  WD40/YVTN_repeat-like_dom UniProtKB/TrEMBL
  WD40_repeat UniProtKB/TrEMBL
  WD40_repeat_CS UniProtKB/TrEMBL
  WD40_repeat_dom_sf UniProtKB/TrEMBL
KEGG Report rno:361765 UniProtKB/TrEMBL
MGC_CLONE MGC:105884 IMAGE-MGC_LOAD
NCBI Gene 361765 ENTREZGENE
Pfam Beta-TrCP_D UniProtKB/TrEMBL
  F-box-like UniProtKB/TrEMBL
  WD40 UniProtKB/TrEMBL
PhenoGen Btrc PhenoGen
PRINTS GPROTEINBRPT UniProtKB/TrEMBL
PROSITE FBOX UniProtKB/TrEMBL
  WD_REPEATS_1 UniProtKB/TrEMBL
  WD_REPEATS_2 UniProtKB/TrEMBL
SMART Beta-TrCP_D UniProtKB/TrEMBL
  FBOX UniProtKB/TrEMBL
  WD40 UniProtKB/TrEMBL
Superfamily-SCOP F-box_dom_Skp2-like UniProtKB/TrEMBL
  WD40_like UniProtKB/TrEMBL
UniProt A0A8I5ZMD6_RAT UniProtKB/TrEMBL
  A0A8I5ZRU0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZWB9_RAT UniProtKB/TrEMBL
  A0A8I5ZX54 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AFI6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ASK3_RAT UniProtKB/TrEMBL
  A0A8I6G2R1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GHM9 ENTREZGENE, UniProtKB/TrEMBL
  F1LMH8 ENTREZGENE, UniProtKB/TrEMBL
  Q5U4E5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-07-13 Btrc  beta-transducin repeat containing E3 ubiquitin protein ligase  Btrc  beta-transducin repeat containing  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Btrc  beta-transducin repeat containing      Symbol and Name status set to approved 1299863 APPROVED
2005-07-29 Btrc  beta-transducin repeat containing      Symbol and Name status set to provisional 70820 PROVISIONAL