 Gene-Chemical Interaction Annotations | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology AnnotationsMolecular Pathway Annotations |
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Analyze GeneStrainQTL List |
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GOLF (Gene-Ortholog Location Finder) |
Gene Ontology AnnotationsMolecular Pathway AnnotationsDisease AnnotationsGene-Chemical Interaction Annotations
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Gene Ontology AnnotationsBiological Process
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Cellular Component
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Molecular Function
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Molecular Pathway AnnotationsReferences - curated| 1. | Cohen MM, Am J Med Genet A. 2010 Aug;152A(8):1875-914. doi: 10.1002/ajmg.a.32909. |
| 2. | Cuadrado A Free Radic Biol Med. 2015 Nov;88(Pt B):147-57. doi: 10.1016/j.freeradbiomed.2015.04.029. Epub 2015 Apr 30. |
| 3. | Hayes JD and Dinkova-Kostova AT, Trends Biochem Sci. 2014 Apr;39(4):199-218. doi: 10.1016/j.tibs.2014.02.002. Epub 2014 Mar 16. |
| 4. | Klaus A and Birchmeier W, Nat Rev Cancer. 2008 May;8(5):387-98. |
| 5. | Liu S and Chen ZJ, Cell Res. 2011 Jan;21(1):6-21. Epub 2010 Dec 7. |
| 6. | MGD data from the GO Consortium |
| 7. | Pipeline to import KEGG annotations from KEGG into RGD |
| 8. | RGD automated data pipeline |
| 9. | RGD automated import pipeline for gene-chemical interactions |
| 10. | Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11. |
| 11. | Wang X, etal., Arterioscler Thromb Vasc Biol 2004 Jan;24(1):85-90. Epub 2003 Oct 30. |
References - uncurated| PubMed | 10228155 11158290 12791266 12820959 12843402 14673179 15340078 15448698 15917222 16885022 18354482 18723513 18782782 18929646 19028597 19103752 19966869 21258371 21873635 21911472 23640883 23850969 |
Genomics
Comparative Map Data| Btrc (Rattus norvegicus - Norway rat) |
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| BTRC (Homo sapiens - human) |
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| Btrc (Mus musculus - house mouse) |
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| Btrc (Chinchilla lanigera - long-tailed chinchilla) |
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| BTRC (Pan paniscus - bonobo/pygmy chimpanzee) |
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| BTRC (Canis lupus familiaris - dog) |
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| Btrc (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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| BTRC (Sus scrofa - pig) |
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Position Markers| D1Got234 |
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| D1Got434 |
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| BF412449 |
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| RH138908 |
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QTLs in Region (Rnor_6.0)| The following QTLs overlap with this region. |  | Full Report | | CSV | | TAB | | Printer | | Gviewer |
miRNA Target Status
Predicted Target Of
| The detailed report is available here: | | Full Report | | CSV | | TAB | | Printer |
miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/). For more information about miRGate, see PMID:25858286 or access the full paper here. |
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Expression
RNA-SEQ ExpressionHigh: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM
| testis | heart | brain | ovary | uterus | skeletal muscle tissue | colon | gastrocnemius | forebrain | hindbrain | lung | spleen | liver | kidney | adrenal gland | thymus | |
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| High | ||||||||||||||||
| Medium | 22 | 26 | 23 | 15 | 2 | 2 | 26 | 25 | 3 | 6 | 22 | 20 | 6 | |||
| Low | 17 | 2 | 1 | 3 | 8 | 8 | 5 | 19 | 15 | 2 | 8 | |||||
| Below cutoff |
View RNA-SEQ Expression Data
Sequence
Nucleotide Sequences| RefSeq Transcripts | NM_001007148 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
| XM_006231529 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XM_006231530 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XM_006231531 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XM_006231535 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XM_006231536 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XM_006231537 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XM_006231538 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XM_006231539 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XM_006231541 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XM_006231543 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XM_017589454 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| XM_017589455 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| GenBank Nucleotide | AAHX01000545 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
| AAHX01000546 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AAHX01000547 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AAHX01000548 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AAHX01000549 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AC097970 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| AC111315 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| BC085125 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| CB584165 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| CH473986 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| EV771066 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
| FQ232628 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
Reference Sequences
| RefSeq Acc Id: | NM_001007148 ⟹ NP_001007149 | ||||||||||||||||||||||||
| RefSeq Status: | VALIDATED | ||||||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||||||
| Position: |
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| Sequence: |
GAAGAGGAGGCGGGATCCGGGCGCTGCGTTGGCTGCGGCCTGCCACGAAAGGGGCGGCCCCGGChide sequence |
| RefSeq Acc Id: | XM_006231529 ⟹ XP_006231591 | ||||||||||||||
| RefSeq Status: | |||||||||||||||
| Type: | CODING | ||||||||||||||
| Position: |
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| Sequence: |
AGGGTTTCTCTGTGTAGTCCTGGCTGACCTGGACTCCTTCTGTAGACTCATTATGTATGGCTTChide sequence |
| RefSeq Acc Id: | XM_006231530 ⟹ XP_006231592 | ||||||||||||||
| RefSeq Status: | |||||||||||||||
| Type: | CODING | ||||||||||||||
| Position: |
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| Sequence: |
GTACCCTGCCAGTGCCAGGAGGTAAAGAGAGGGCGGGGGAAGGAAGAGGAGGCGGGATCCGGGChide sequence |
| RefSeq Acc Id: | XM_006231531 ⟹ XP_006231593 | ||||||||||||||
| RefSeq Status: | |||||||||||||||
| Type: | CODING | ||||||||||||||
| Position: |
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| Sequence: |
GGGTACCCTGCCAGTGCCAGGAGGTAAAGAGAGGGCGGGGGAAGGAAGAGGAGGCGGGATCCGGhide sequence |
| RefSeq Acc Id: | XM_006231535 ⟹ XP_006231597 | ||||||||||||||
| RefSeq Status: | |||||||||||||||
| Type: | CODING | ||||||||||||||
| Position: |
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| Sequence: |
ACAAGCCAAGTGACAGCGGGAGCTCATTCGAGTGCTCTATGCCCAGGTCTCTGTGGCTGGGCTGhide sequence |
| RefSeq Acc Id: | XM_006231536 ⟹ XP_006231598 | ||||||||||||||
| RefSeq Status: | |||||||||||||||
| Type: | CODING | ||||||||||||||
| Position: |
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| Sequence: |
GTACCCTGCCAGTGCCAGGAGGTAAAGAGAGGGCGGGGGAAGGAAGAGGAGGCGGGATCCGGGChide sequence |
| RefSeq Acc Id: | XM_006231537 ⟹ XP_006231599 | ||||||||||||||
| RefSeq Status: | |||||||||||||||
| Type: | CODING | ||||||||||||||
| Position: |
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| Sequence: |
GGGTTTCTCTGTGTAGTCCTGGCTGACCTGGACTCCTTCTGTAGACTCATTATGTATGGCTTCAhide sequence |
| RefSeq Acc Id: | XM_006231538 ⟹ XP_006231600 | ||||||||||||||
| RefSeq Status: | |||||||||||||||
| Type: | CODING | ||||||||||||||
| Position: |
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| Sequence: |
TACCCTGCCAGTGCCAGGAGGTAAAGAGAGGGCGGGGGAAGGAAGAGGAGGCGGGATCCGGGCGhide sequence |
| RefSeq Acc Id: | XM_006231539 ⟹ XP_006231601 | ||||||||||||||
| RefSeq Status: | |||||||||||||||
| Type: | CODING | ||||||||||||||
| Position: |
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| Sequence: |
GTATGAAAATATTTTTAAAAGGAATATTAGTTCTGGTCTGACAGGAAAATAACCAGCCTATGCGhide sequence |
| RefSeq Acc Id: | XM_006231541 ⟹ XP_006231603 | ||||||||||||||
| RefSeq Status: | |||||||||||||||
| Type: | CODING | ||||||||||||||
| Position: |
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| Sequence: |
AAATTAAATGTATAAATGTTGGGGTACTCAAATTAAGGTTATAAGACAGCTTGACTCTCTTCCThide sequence |
| RefSeq Acc Id: | XM_006231543 ⟹ XP_006231605 | ||||||||||||||
| RefSeq Status: | |||||||||||||||
| Type: | CODING | ||||||||||||||
| Position: |
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| Sequence: |
GTATGAAAATATTTTTAAAAGGAATATTAGTTCTGGTCTGACAGGAAAATAACCAGCCTATGCGhide sequence |
| RefSeq Acc Id: | XM_017589454 ⟹ XP_017444943 | |||||||||
| RefSeq Status: | ||||||||||
| Type: | CODING | |||||||||
| Position: |
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| Sequence: |
AAGGGGCGTGGGGACAGTTACTGAAGAGCGGAGGAACCCGGGTGGAGAAACGCCTGTAGACGCThide sequence |
| RefSeq Acc Id: | XM_017589455 ⟹ XP_017444944 | |||||||||
| RefSeq Status: | ||||||||||
| Type: | CODING | |||||||||
| Position: |
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| Sequence: |
GCTGCAGTTCCGGCTGGTGGATATTGGAGGAATAATAAAAAGTTTCTGTCCTGGGATTGTTTTGhide sequence |
Protein Sequences| Protein RefSeqs | NP_001007149 | (Get FASTA) | NCBI Sequence Viewer |
| XP_006231591 | (Get FASTA) | NCBI Sequence Viewer | |
| XP_006231592 | (Get FASTA) | NCBI Sequence Viewer | |
| XP_006231593 | (Get FASTA) | NCBI Sequence Viewer | |
| XP_006231597 | (Get FASTA) | NCBI Sequence Viewer | |
| XP_006231598 | (Get FASTA) | NCBI Sequence Viewer | |
| XP_006231599 | (Get FASTA) | NCBI Sequence Viewer | |
| XP_006231600 | (Get FASTA) | NCBI Sequence Viewer | |
| XP_006231601 | (Get FASTA) | NCBI Sequence Viewer | |
| XP_006231603 | (Get FASTA) | NCBI Sequence Viewer | |
| XP_006231605 | (Get FASTA) | NCBI Sequence Viewer | |
| XP_017444943 | (Get FASTA) | NCBI Sequence Viewer | |
| XP_017444944 | (Get FASTA) | NCBI Sequence Viewer | |
| GenBank Protein | AAH85125 | (Get FASTA) | NCBI Sequence Viewer |
| EDL94307 | (Get FASTA) | NCBI Sequence Viewer |
Reference Sequences
| RefSeq Acc Id: | NP_001007149 ⟸ NM_001007148 |
| - UniProtKB: | Q5U4E5 (UniProtKB/TrEMBL) |
| - Sequence: |
MDPAEAVLQEKALKFMAAVPAGGYWRNNKKCSMPRSLWLGCSSLADSMPSLRCLYNPGTGALTAhide sequence |
| RefSeq Acc Id: | XP_006231593 ⟸ XM_006231531 |
| - Peptide Label: | isoform X3 |
| - Sequence: |
MDPAEAVLQEKALKFMAAVPAGGYWRNNKKCSMPRSLWLGCSSLADSMPSLRCLYNPGTGALTAhide sequence |
| RefSeq Acc Id: | XP_006231598 ⟸ XM_006231536 |
| - Peptide Label: | isoform X5 |
| - Sequence: |
MDPAEAVLQEKALKFMAAVPAGGYWRNNKKNSSEREDCNNGEPPRKIIPEKNSLRQTYNSCARLhide sequence |
| RefSeq Acc Id: | XP_006231592 ⟸ XM_006231530 |
| - Peptide Label: | isoform X2 |
| - Sequence: |
MDPAEAVLQEKALKFMCSMPRSLWLGCSSLADSMPSLRCLYNPGTGALTAFQNSSEREDCNNGEhide sequence |
| RefSeq Acc Id: | XP_006231600 ⟸ XM_006231538 |
| - Peptide Label: | isoform X7 |
| - Sequence: |
MDPAEAVLQEKALKFMNSSEREDCNNGEPPRKIIPEKNSLRQTYNSCARLCINQETVCLTSTAMhide sequence |
| RefSeq Acc Id: | XP_006231597 ⟸ XM_006231535 |
| - Peptide Label: | isoform X4 |
| - UniProtKB: | F1LMH8 (UniProtKB/TrEMBL) |
| - Sequence: |
MPRSLWLGCSSLADSMPSLRCLYNPGTGALTAFQNSSEREDCNNGEPPRKIIPEKNSLRQTYNShide sequence |
| RefSeq Acc Id: | XP_006231591 ⟸ XM_006231529 |
| - Peptide Label: | isoform X1 |
| - Sequence: |
MASDSQRPVAAVPAGGYWRNNKKCSMPRSLWLGCSSLADSMPSLRCLYNPGTGALTAFQNSSERhide sequence |
| RefSeq Acc Id: | XP_006231599 ⟸ XM_006231537 |
| - Peptide Label: | isoform X6 |
| - Sequence: |
MASDSQRPVAAVPAGGYWRNNKKNSSEREDCNNGEPPRKIIPEKNSLRQTYNSCARLCINQETVhide sequence |
| RefSeq Acc Id: | XP_006231605 ⟸ XM_006231543 |
| - Peptide Label: | isoform X8 |
| - UniProtKB: | Q5U4E5 (UniProtKB/TrEMBL) |
| - Sequence: |
MKTENCVAKTKLANGTSSMIVPKQRKLSASYEKEKELCVKYFEQWSESDQVEFVEHLISQMCHYhide sequence |
| RefSeq Acc Id: | XP_006231601 ⟸ XM_006231539 |
| - Peptide Label: | isoform X8 |
| - UniProtKB: | Q5U4E5 (UniProtKB/TrEMBL) |
| - Sequence: |
MKTENCVAKTKLANGTSSMIVPKQRKLSASYEKEKELCVKYFEQWSESDQVEFVEHLISQMCHYhide sequence |
| RefSeq Acc Id: | XP_006231603 ⟸ XM_006231541 |
| - Peptide Label: | isoform X8 |
| - UniProtKB: | Q5U4E5 (UniProtKB/TrEMBL) |
| - Sequence: |
MKTENCVAKTKLANGTSSMIVPKQRKLSASYEKEKELCVKYFEQWSESDQVEFVEHLISQMCHYhide sequence |
| RefSeq Acc Id: | XP_017444943 ⟸ XM_017589454 |
| - Peptide Label: | isoform X4 |
| - UniProtKB: | F1LMH8 (UniProtKB/TrEMBL) |
| - Sequence: |
MPRSLWLGCSSLADSMPSLRCLYNPGTGALTAFQNSSEREDCNNGEPPRKIIPEKNSLRQTYNShide sequence |
| RefSeq Acc Id: | XP_017444944 ⟸ XM_017589455 |
| - Peptide Label: | isoform X4 |
| - UniProtKB: | F1LMH8 (UniProtKB/TrEMBL) |
| - Sequence: |
MPRSLWLGCSSLADSMPSLRCLYNPGTGALTAFQNSSEREDCNNGEPPRKIIPEKNSLRQTYNShide sequence |
TranscriptomeStrain Variation
Strain Sequence Variants (Rnor 6.0)
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Additional Information
External Database Links| Database | Acc Id | Source(s) |
| AGR Gene | RGD:1359721 | AgrOrtholog |
| Ensembl Genes | ENSRNOG00000016280 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Protein | ENSRNOP00000022426 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Transcript | ENSRNOT00000022426 | ENTREZGENE, UniProtKB/TrEMBL |
| Gene3D-CATH | 2.130.10.10 | UniProtKB/TrEMBL |
| IMAGE_CLONE | IMAGE:7131883 | IMAGE-MGC_LOAD |
| InterPro | Beta-TrCP_D | UniProtKB/TrEMBL |
| F-box_dom_cyclin-like | UniProtKB/TrEMBL | |
| F-box_dom_like | UniProtKB/TrEMBL | |
| G-protein_beta_WD-40_rep | UniProtKB/TrEMBL | |
| WD40/YVTN_repeat-like_dom | UniProtKB/TrEMBL | |
| WD40_repeat | UniProtKB/TrEMBL | |
| WD40_repeat_CS | UniProtKB/TrEMBL | |
| WD40_repeat_dom | UniProtKB/TrEMBL | |
| WD40_repeat_dom_sf | UniProtKB/TrEMBL | |
| KEGG Report | rno:361765 | UniProtKB/TrEMBL |
| MGC_CLONE | MGC:105884 | IMAGE-MGC_LOAD |
| NCBI Gene | 361765 | ENTREZGENE |
| Pfam | Beta-TrCP_D | UniProtKB/TrEMBL |
| F-box-like | UniProtKB/TrEMBL | |
| WD40 | UniProtKB/TrEMBL | |
| PhenoGen | Btrc | PhenoGen |
| PRINTS | GPROTEINBRPT | UniProtKB/TrEMBL |
| PROSITE | FBOX | UniProtKB/TrEMBL |
| WD_REPEATS_1 | UniProtKB/TrEMBL | |
| WD_REPEATS_2 | UniProtKB/TrEMBL | |
| WD_REPEATS_REGION | UniProtKB/TrEMBL | |
| SMART | Beta-TrCP_D | UniProtKB/TrEMBL |
| FBOX | UniProtKB/TrEMBL | |
| WD40 | UniProtKB/TrEMBL | |
| Superfamily-SCOP | F-box_dom_Skp2-like | UniProtKB/TrEMBL |
| WD40_like | UniProtKB/TrEMBL | |
| UniGene | Rn.21800 | ENTREZGENE |
| UniProt | F1LMH8 | ENTREZGENE, UniProtKB/TrEMBL |
| Q5U4E5 | ENTREZGENE, UniProtKB/TrEMBL |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2012-07-13 | Btrc | beta-transducin repeat containing E3 ubiquitin protein ligase | Btrc | beta-transducin repeat containing | Nomenclature updated to reflect human and mouse nomenclature | 1299863 | APPROVED |
| 2006-03-30 | Btrc | beta-transducin repeat containing | Symbol and Name status set to approved | 1299863 | APPROVED | ||
| 2005-07-29 | Btrc | beta-transducin repeat containing | Symbol and Name status set to provisional | 70820 | PROVISIONAL |
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| More on Btrc | |
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Alliance Gene |
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NCBI Gene |
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Ensembl Gene |
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JBrowse: rn5 rn6 |
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NCBI Genome Data Viewer |
| RGD Object Information | |
| RGD ID: | 1359721 |
| Created: | 2005-07-29 |
| Species: | Rattus norvegicus |
| Last Modified: | 2019-11-27 |
| Status: | ACTIVE |
