Gbf1 (golgi brefeldin A resistant guanine nucleotide exchange factor 1) - Rat Genome Database

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Gene: Gbf1 (golgi brefeldin A resistant guanine nucleotide exchange factor 1) Rattus norvegicus
Analyze
Symbol: Gbf1
Name: golgi brefeldin A resistant guanine nucleotide exchange factor 1
RGD ID: 1307160
Description: Predicted to enable phosphatidylinositol-3,4,5-trisphosphate binding activity and phosphatidylinositol-3,5-bisphosphate binding activity. Predicted to be involved in several processes, including Golgi disassembly; Golgi vesicle transport; and protein localization to organelle. Located in Golgi stack; endoplasmic reticulum lumen; and peroxisome. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease dominant intermediate A. Orthologous to human GBF1 (golgi brefeldin A resistant guanine nucleotide exchange factor 1); PARTICIPATES IN Arf family mediated signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; chloroprene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: golgi-specific brefeldin A resistant guanine nucleotide exchange factor 1; golgi-specific brefeldin A-resistance factor 1; Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1; LOC309451; RGD1307160; similar to golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81254,959,784 - 255,088,479 (+)NCBIGRCr8
mRatBN7.21245,018,535 - 245,147,052 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1245,018,568 - 245,147,042 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1253,140,270 - 253,268,687 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01259,835,181 - 259,963,390 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01252,487,000 - 252,615,168 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01265,904,616 - 266,033,107 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1265,904,566 - 266,033,156 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01273,334,980 - 273,464,048 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41251,373,242 - 251,501,663 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11251,723,054 - 251,763,642 (+)NCBI
Celera1240,801,947 - 240,930,218 (+)NCBICelera
Cytogenetic Map1q54NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. GBF1: A novel Golgi-associated BFA-resistant guanine nucleotide exchange factor that displays specificity for ADP-ribosylation factor 5. Claude A, etal., J Cell Biol. 1999 Jul 12;146(1):71-84.
2. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Comprehensive gene review and curation RGD comprehensive gene curation
7. Localization of large ADP-ribosylation factor-guanine nucleotide exchange factors to different Golgi compartments: evidence for distinct functions in protein traffic. Zhao X, etal., Mol Biol Cell. 2002 Jan;13(1):119-33.
Additional References at PubMed
PMID:12047556   PMID:12808027   PMID:17956946   PMID:19946888   PMID:22573891   PMID:23386609   PMID:23418352   PMID:28389568  


Genomics

Comparative Map Data
Gbf1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81254,959,784 - 255,088,479 (+)NCBIGRCr8
mRatBN7.21245,018,535 - 245,147,052 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1245,018,568 - 245,147,042 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1253,140,270 - 253,268,687 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01259,835,181 - 259,963,390 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01252,487,000 - 252,615,168 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01265,904,616 - 266,033,107 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1265,904,566 - 266,033,156 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01273,334,980 - 273,464,048 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41251,373,242 - 251,501,663 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11251,723,054 - 251,763,642 (+)NCBI
Celera1240,801,947 - 240,930,218 (+)NCBICelera
Cytogenetic Map1q54NCBI
GBF1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810102,230,643 - 102,382,896 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl10102,245,371 - 102,382,899 (+)EnsemblGRCh38hg38GRCh38
GRCh3710103,990,400 - 104,142,653 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3610103,995,299 - 104,132,639 (+)NCBINCBI36Build 36hg18NCBI36
Build 3410103,995,298 - 104,132,639NCBI
Celera1097,746,227 - 97,883,548 (+)NCBICelera
Cytogenetic Map10q24.32NCBI
HuRef1097,637,542 - 97,775,465 (+)NCBIHuRef
CHM1_110104,288,779 - 104,426,082 (+)NCBICHM1_1
T2T-CHM13v2.010103,115,630 - 103,267,847 (+)NCBIT2T-CHM13v2.0
Gbf1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391946,140,948 - 46,274,949 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1946,140,948 - 46,274,949 (+)EnsemblGRCm39 Ensembl
GRCm381946,152,509 - 46,286,510 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1946,152,509 - 46,286,510 (+)EnsemblGRCm38mm10GRCm38
MGSCv371946,227,048 - 46,361,000 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361946,205,869 - 46,339,821 (+)NCBIMGSCv36mm8
Celera1946,916,366 - 47,049,730 (+)NCBICelera
Cytogenetic Map19C3NCBI
cM Map1938.75NCBI
Gbf1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554858,006,706 - 8,115,561 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554858,006,161 - 8,126,074 (-)NCBIChiLan1.0ChiLan1.0
GBF1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28114,132,933 - 114,270,450 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110114,138,308 - 114,275,772 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01098,849,000 - 98,986,443 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.110102,316,329 - 102,452,439 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl10102,316,329 - 102,452,439 (+)Ensemblpanpan1.1panPan2
GBF1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12814,775,431 - 14,896,121 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2814,788,369 - 14,895,978 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2814,947,856 - 15,068,574 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02815,249,244 - 15,370,247 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2815,249,266 - 15,370,237 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12814,794,581 - 14,915,297 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02814,833,489 - 14,954,383 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02814,966,253 - 15,086,996 (+)NCBIUU_Cfam_GSD_1.0
Gbf1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721331,875,820 - 32,000,999 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366003,479,048 - 3,604,241 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366003,479,045 - 3,604,241 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GBF1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14113,245,502 - 113,379,471 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114113,245,486 - 113,379,472 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214123,099,432 - 123,233,891 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GBF1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1995,281,953 - 95,416,050 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl995,281,954 - 95,416,086 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604856,384,219 - 56,521,573 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gbf1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248311,665,193 - 1,798,149 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248311,665,507 - 1,801,409 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gbf1
237 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:131
Count of miRNA genes:92
Interacting mature miRNAs:109
Transcripts:ENSRNOT00000036156
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1150700142252085212Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1150700247252085048Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1156677124256448636Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1176426412257976495Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1177227632256448636Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1177227632256448636Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1179567751260522016Rat
1358898Bp255Blood pressure QTL 2553.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1191019702246062233Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1195804352257091168Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1199050459259647894Rat
2293694Bss38Bone structure and strength QTL 387.050.0001femur strength trait (VT:0010010)femur stiffness (CMO:0001674)1201554356246554356Rat
7394701Uae46Urinary albumin excretion QTL 463.60.0056urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1201554356246554356Rat
2300175Bmd40Bone mineral density QTL 4015.40.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)1201554356246554356Rat
2293655Bss36Bone structure and strength QTL 3610.660.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1201554356246554356Rat
2293674Bss39Bone structure and strength QTL 397.10.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)1201554356246554356Rat
10059587Bw173Body weight QTL 1733.230.025body mass (VT:0001259)body weight (CMO:0000012)1202069611247069611Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1206081677251081677Rat
1357399Bw45Body weight QTL 453.05body mass (VT:0001259)body mass index (BMI) (CMO:0000105)1206329708251329708Rat
1357404Bw42Body weight QTL 424.490.0001body mass (VT:0001259)body weight (CMO:0000012)1206329708251329708Rat
1358890Bp259Blood pressure QTL 2593.06arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1210702053260522016Rat
724538Kidm1Kidney mass QTL 13.2kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1213707201252085212Rat
734768Niddm59Non-insulin dependent diabetes mellitus QTL 59body mass (VT:0001259)body weight (CMO:0000012)1213843987258843987Rat
70211Niddm24Non-insulin dependent diabetes mellitus QTL 243.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1214647894259647894Rat
1549910Bw54Body weight QTL 540.05body mass (VT:0001259)body weight (CMO:0000012)1214647894259647894Rat
61327Eae7Experimental allergic encephalomyelitis QTL 75.6body mass (VT:0001259)change in body weight (CMO:0002045)1216255568260522016Rat
2302040Pia35Pristane induced arthritis QTL 353.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1216255568260522016Rat
1598821Rf55Renal function QTL 556.3renal blood flow trait (VT:2000006)ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)1218748008257976495Rat
61400Niddm1Non-insulin dependent diabetes mellitus QTL 111blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1218753689245907899Rat
724533Rf51Renal function QTL 515.30.0002kidney plasma flow trait (VT:0005524)renal plasma flow (CMO:0001914)1218753816256448513Rat
731175Uae20Urinary albumin excretion QTL 203.50.0018urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1221264111259647894Rat
10053715Scort24Serum corticosterone level QTL 242.130.0088blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1221414816260522016Rat
724552Glom2Glomerulus QTL 23.30.0001kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)1222363780260522016Rat
1600392Bw123Body weight QTL 1230.001body mass (VT:0001259)body weight (CMO:0000012)1223201027260522016Rat
734767Niddm57Non-insulin dependent diabetes mellitus QTL 57body mass (VT:0001259)body weight (CMO:0000012)1224054293260122809Rat
631843Bw116Body weight QTL 1164.10.016abdominal adipose amount (VT:1000220)abdominal fat pad weight (CMO:0000088)1224054293260122809Rat
734769Niddm58Non-insulin dependent diabetes mellitus QTL 58body mass (VT:0001259)body weight (CMO:0000012)1224569538260122809Rat
631215Stl8Serum triglyceride level QTL 89.270.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1225126575260522016Rat
1300108Rf8Renal function QTL 83.75renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)1228581588259647894Rat
2316896Gluco57Glucose level QTL 577.2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1228985440245907899Rat
1581544Rf52Renal function QTL 520.05urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)1232156370259647894Rat
631669Iddm9Insulin dependent diabetes mellitus QTL 92.80.039blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1233190394258625266Rat
631536Lnnr2Liver neoplastic nodule remodeling QTL 22.90.0005liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)1233948574260522016Rat
631690Scl5Serum cholesterol level QTL 52.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1236125214260522016Rat
631836Stl31Serum triglyceride level QTL 314.640.00000487blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1237147813260522016Rat
631837Niddm35Non-insulin dependent diabetes mellitus QTL 350.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1238699859259647894Rat

Markers in Region
RH128849  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21245,146,837 - 245,146,991 (+)MAPPERmRatBN7.2
Rnor_6.01266,032,893 - 266,033,046NCBIRnor6.0
Rnor_5.01273,463,834 - 273,463,987UniSTSRnor5.0
RGSC_v3.41251,501,449 - 251,501,602UniSTSRGSC3.4
Celera1240,930,004 - 240,930,157UniSTS
RH 3.4 Map11623.6UniSTS
Cytogenetic Map1q54UniSTS
AI035702  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21245,146,700 - 245,146,964 (+)MAPPERmRatBN7.2
Rnor_6.01266,032,756 - 266,033,019NCBIRnor6.0
Rnor_5.01273,463,697 - 273,463,960UniSTSRnor5.0
RGSC_v3.41251,501,312 - 251,501,575UniSTSRGSC3.4
Celera1240,929,867 - 240,930,130UniSTS
Cytogenetic Map1q54UniSTS
RH143137  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21245,099,693 - 245,099,851 (+)MAPPERmRatBN7.2
Rnor_6.01265,985,757 - 265,985,914NCBIRnor6.0
Rnor_5.01273,416,698 - 273,416,855UniSTSRnor5.0
RGSC_v3.41251,454,313 - 251,454,470UniSTSRGSC3.4
Celera1240,882,883 - 240,883,040UniSTS
RH 3.4 Map11623.6UniSTS
Cytogenetic Map1q54UniSTS
BE103146  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21245,098,970 - 245,099,144 (+)MAPPERmRatBN7.2
Rnor_6.01265,985,034 - 265,985,207NCBIRnor6.0
Rnor_5.01273,415,975 - 273,416,148UniSTSRnor5.0
RGSC_v3.41251,453,590 - 251,453,763UniSTSRGSC3.4
Celera1240,882,160 - 240,882,333UniSTS
RH 3.4 Map11624.6UniSTS
Cytogenetic Map1q54UniSTS
BE108790  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21245,136,170 - 245,136,364 (+)MAPPERmRatBN7.2
Rnor_6.01266,022,229 - 266,022,422NCBIRnor6.0
Rnor_5.01273,453,170 - 273,453,363UniSTSRnor5.0
RGSC_v3.41251,490,785 - 251,490,978UniSTSRGSC3.4
Celera1240,919,342 - 240,919,535UniSTS
RH 3.4 Map11624.7UniSTS
Cytogenetic Map1q54UniSTS
BF406297  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21245,122,186 - 245,122,400 (+)MAPPERmRatBN7.2
Rnor_6.01266,008,248 - 266,008,461NCBIRnor6.0
Rnor_5.01273,439,189 - 273,439,402UniSTSRnor5.0
RGSC_v3.41251,476,804 - 251,477,017UniSTSRGSC3.4
Celera1240,905,371 - 240,905,584UniSTS
RH 3.4 Map11627.3UniSTS
Cytogenetic Map1q54UniSTS
RH137769  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21245,117,695 - 245,117,842 (+)MAPPERmRatBN7.2
Rnor_6.01266,003,757 - 266,003,903NCBIRnor6.0
Rnor_5.01273,434,698 - 273,434,844UniSTSRnor5.0
RGSC_v3.41251,472,313 - 251,472,459UniSTSRGSC3.4
Celera1240,900,880 - 240,901,026UniSTS
RH 3.4 Map11628.7UniSTS
Cytogenetic Map1q54UniSTS
RH138408  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21245,093,783 - 245,093,921 (+)MAPPERmRatBN7.2
Rnor_6.01265,979,849 - 265,979,986NCBIRnor6.0
Rnor_5.01273,410,790 - 273,410,927UniSTSRnor5.0
RGSC_v3.41251,448,405 - 251,448,542UniSTSRGSC3.4
Celera1240,876,975 - 240,877,112UniSTS
Cytogenetic Map1q54UniSTS
AW049900  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21245,128,210 - 245,128,555 (+)MAPPERmRatBN7.2
Rnor_6.01266,014,270 - 266,014,614NCBIRnor6.0
Rnor_5.01273,445,211 - 273,445,555UniSTSRnor5.0
RGSC_v3.41251,482,826 - 251,483,170UniSTSRGSC3.4
Celera1240,911,383 - 240,911,727UniSTS
Cytogenetic Map1q54UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001191634 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006231496 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006231497 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006231498 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006231500 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006231501 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006231502 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039080486 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039080492 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063264948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063264959 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063264977 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063264979 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC096363 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC096600 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC119478 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473986 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216888 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000036156   ⟹   ENSRNOP00000038037
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1245,018,568 - 245,147,042 (+)Ensembl
Rnor_6.0 Ensembl1265,904,687 - 266,033,107 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000086041   ⟹   ENSRNOP00000072707
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1265,904,566 - 266,033,156 (+)Ensembl
RefSeq Acc Id: NM_001191634   ⟹   NP_001178563
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81254,960,065 - 255,088,479 (+)NCBI
mRatBN7.21245,018,621 - 245,147,052 (+)NCBI
Rnor_6.01265,904,687 - 266,033,107 (+)NCBI
Rnor_5.01273,334,980 - 273,464,048 (+)NCBI
Celera1240,801,947 - 240,930,218 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006231496   ⟹   XP_006231558
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81254,959,985 - 255,088,472 (+)NCBI
mRatBN7.21245,018,536 - 245,147,045 (+)NCBI
Rnor_6.01265,904,616 - 266,033,100 (+)NCBI
Rnor_5.01273,334,980 - 273,464,048 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006231497   ⟹   XP_006231559
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81254,959,985 - 255,088,472 (+)NCBI
mRatBN7.21245,018,536 - 245,147,045 (+)NCBI
Rnor_6.01265,904,616 - 266,033,100 (+)NCBI
Rnor_5.01273,334,980 - 273,464,048 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006231498   ⟹   XP_006231560
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81254,959,986 - 255,088,472 (+)NCBI
mRatBN7.21245,018,537 - 245,147,045 (+)NCBI
Rnor_6.01265,904,616 - 266,033,100 (+)NCBI
Rnor_5.01273,334,980 - 273,464,048 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006231500   ⟹   XP_006231562
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81254,959,784 - 255,088,472 (+)NCBI
mRatBN7.21245,018,568 - 245,146,475 (+)NCBI
Rnor_6.01265,904,634 - 266,033,100 (+)NCBI
Rnor_5.01273,334,980 - 273,464,048 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006231501   ⟹   XP_006231563
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81254,959,784 - 255,088,472 (+)NCBI
mRatBN7.21245,018,568 - 245,146,475 (+)NCBI
Rnor_6.01265,904,634 - 266,033,100 (+)NCBI
Rnor_5.01273,334,980 - 273,464,048 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006231502   ⟹   XP_006231564
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81254,959,855 - 255,088,472 (+)NCBI
mRatBN7.21245,018,538 - 245,146,475 (+)NCBI
Rnor_6.01265,904,616 - 266,033,100 (+)NCBI
Rnor_5.01273,334,980 - 273,464,048 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039080486   ⟹   XP_038936414
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81254,959,985 - 255,088,472 (+)NCBI
mRatBN7.21245,018,535 - 245,147,045 (+)NCBI
RefSeq Acc Id: XM_039080492   ⟹   XP_038936420
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81254,959,985 - 255,088,472 (+)NCBI
mRatBN7.21245,018,536 - 245,147,045 (+)NCBI
RefSeq Acc Id: XM_063264948   ⟹   XP_063121018
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81254,959,986 - 255,088,472 (+)NCBI
RefSeq Acc Id: XM_063264959   ⟹   XP_063121029
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81254,959,986 - 255,088,472 (+)NCBI
RefSeq Acc Id: XM_063264977   ⟹   XP_063121047
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81254,959,986 - 255,088,472 (+)NCBI
RefSeq Acc Id: XM_063264979   ⟹   XP_063121049
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81254,959,986 - 255,088,472 (+)NCBI
RefSeq Acc Id: NP_001178563   ⟸   NM_001191634
- UniProtKB: A6JHL5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006231558   ⟸   XM_006231496
- Peptide Label: isoform X1
- UniProtKB: A6JHL5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006231560   ⟸   XM_006231498
- Peptide Label: isoform X3
- UniProtKB: A6JHL5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006231559   ⟸   XM_006231497
- Peptide Label: isoform X2
- UniProtKB: A6JHL5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006231562   ⟸   XM_006231500
- Peptide Label: isoform X8
- UniProtKB: A6JHL5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006231563   ⟸   XM_006231501
- Peptide Label: isoform X9
- UniProtKB: F1M8X9 (UniProtKB/TrEMBL),   A6JHL5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006231564   ⟸   XM_006231502
- Peptide Label: isoform X10
- UniProtKB: A6JHL5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000038037   ⟸   ENSRNOT00000036156
RefSeq Acc Id: ENSRNOP00000072707   ⟸   ENSRNOT00000086041
RefSeq Acc Id: XP_038936414   ⟸   XM_039080486
- Peptide Label: isoform X5
- UniProtKB: A6JHL5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038936420   ⟸   XM_039080492
- Peptide Label: isoform X6
- UniProtKB: A6JHL5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063121047   ⟸   XM_063264977
- Peptide Label: isoform X11
RefSeq Acc Id: XP_063121049   ⟸   XM_063264979
- Peptide Label: isoform X12
RefSeq Acc Id: XP_063121018   ⟸   XM_063264948
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063121029   ⟸   XM_063264959
- Peptide Label: isoform X7
Protein Domains
SEC7

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1M8X9-F1-model_v2 AlphaFold F1M8X9 1-1861 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690982
Promoter ID:EPDNEW_R1484
Type:multiple initiation site
Name:Gbf1_1
Description:golgi brefeldin A resistant guanine nucleotide exchange factor1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01265,904,634 - 265,904,694EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307160 AgrOrtholog
BioCyc Gene G2FUF-55524 BioCyc
Ensembl Genes ENSRNOG00000026048 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000036156.6 UniProtKB/TrEMBL
Gene3D-CATH 1.10.1000.11 UniProtKB/TrEMBL
  1.10.220.20 UniProtKB/TrEMBL
InterPro ARM-type_fold UniProtKB/TrEMBL
  Sec7 UniProtKB/TrEMBL
  SEC7_alpha_orthog UniProtKB/TrEMBL
  Sec7_N UniProtKB/TrEMBL
  Sec7_sf UniProtKB/TrEMBL
NCBI Gene 309451 ENTREZGENE
PANTHER GOLGI-SPECIFIC BREFELDIN A-RESISTANCE GUANINE NUCLEOTIDE EXCHANGE FACTOR 1 UniProtKB/TrEMBL
  GUANYL-NUCLEOTIDE EXCHANGE FACTOR UniProtKB/TrEMBL
Pfam Sec7 UniProtKB/TrEMBL
  Sec7_N UniProtKB/TrEMBL
PharmGKB GBF1 RGD
PhenoGen Gbf1 PhenoGen
PROSITE SEC7 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000026048 RatGTEx
SMART Sec7 UniProtKB/TrEMBL
Superfamily-SCOP Sec7 UniProtKB/TrEMBL
  SSF48371 UniProtKB/TrEMBL
UniProt A6JHL5 ENTREZGENE, UniProtKB/TrEMBL
  F1M8X9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-08-02 Gbf1  golgi brefeldin A resistant guanine nucleotide exchange factor 1  Gbf1  golgi-specific brefeldin A resistant guanine nucleotide exchange factor 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-02-26 Gbf1  golgi-specific brefeldin A resistant guanine nucleotide exchange factor 1  Gbf1  golgi-specific brefeldin A-resistance factor 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-07 Gbf1  golgi-specific brefeldin A-resistance factor 1  RGD1307160_predicted  similar to golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 RGD1307160_predicted  similar to golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 (predicted)  LOC309451_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC309451_predicted  similar to golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL