Abcc2 (ATP binding cassette subfamily C member 2) - Rat Genome Database

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Gene: Abcc2 (ATP binding cassette subfamily C member 2) Rattus norvegicus
Analyze
Symbol: Abcc2
Name: ATP binding cassette subfamily C member 2
RGD ID: 2366
Description: Enables ABC-type transporter activity; bilirubin transmembrane transporter activity; and protein domain specific binding activity. Involved in several processes, including carboxylic acid transport; cellular response to cytokine stimulus; and cellular response to lipid. Located in brush border membrane and intracellular canaliculus. Used to study Dubin-Johnson syndrome; bilirubin metabolic disorder; cholestasis; end stage renal disease; and visual epilepsy. Biomarker of several diseases, including bilirubin metabolic disorder; fatty liver disease; primary biliary cholangitis; status epilepticus; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in bilirubin metabolic disorder (multiple); carcinoma (multiple); drug-induced hepatitis; leukemia (multiple); and non-alcoholic fatty liver disease. Orthologous to human ABCC2 (ATP binding cassette subfamily C member 2); PARTICIPATES IN bile acid signaling pathway; docetaxel pharmacodynamics pathway; doxorubicin pharmacokinetics pathway; INTERACTS WITH (+)-pilocarpine; (-)-epigallocatechin 3-gallate; (S)-colchicine.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: ATP-binding cassette sub-family C member 2; ATP-binding cassette, sub-family C (CFTR/MRP) member 2; ATP-binding cassette, sub-family C (CFTR/MRP), member 2; ATP-binding cassette, subfamily C (CFTR/MRP), member 2; calicular multispecific organic anion transporter; canalicular multidrug resistance protein; canalicular multispecific organic anion transporter; canalicular multispecific organic anion transporter 1; Cmoat; cMRP; cMrp2/cMoat canalicular apical conjugate export pump; mrp; Mrp2; multidrug resistance associated protein 2; multidrug resistance-associated protein 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Abcc2TR-   Abcc2em1Sage  
Genetic Models: SD-Abcc2em1Sage WUN-Abcc2TR-/HsdRrrc
Is Marker For: Strains:   WUN-Abcc2TR-/HsdRrrc  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21242,664,657 - 242,723,239 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1242,664,657 - 242,723,238 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1250,813,581 - 250,872,198 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01257,510,469 - 257,569,198 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01250,163,726 - 250,222,340 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01263,554,426 - 263,612,556 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1263,554,453 - 263,613,252 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01270,999,832 - 271,057,750 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1238,483,399 - 238,539,595 (+)NCBICelera
Cytogenetic Map1q54NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(+/-)-Aegeline  (ISO)
(-)-epigallocatechin 3-gallate  (EXP)
(1->4)-beta-D-glucan  (ISO)
(2,4,5-trichlorophenoxy)acetic acid  (ISO)
(RS)-coclaurine  (ISO)
(RS)-norcoclaurine  (ISO)
(S)-coclaurine  (ISO)
(S)-colchicine  (EXP)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dichloroethane  (ISO)
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 17-glucosiduronic acid  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2',3'-dideoxyadenosine  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
2-acetamidofluorene  (ISO)
2-tert-butylhydroquinone  (EXP,ISO)
3',4',7-trihydroxyisoflavone  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3-chloropropane-1,2-diol  (EXP)
3-methyl-3H-imidazo[4,5-f]quinolin-2-amine  (ISO)
4'-epidoxorubicin  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
4-hydroxynon-2-enal  (EXP,ISO)
5(6)-carboxy-2',7'-dichlorofluorescein  (EXP,ISO)
5-aza-2'-deoxycytidine  (ISO)
5-chloromethylfluorescein diacetate  (ISO)
5-fluorouracil  (ISO)
5-formyltetrahydrofolic acid  (EXP)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
5-methoxypsoralen  (ISO)
6-bromoindirubin-3'-oxime  (ISO)
6-carboxyfluorescein  (ISO)
6-propyl-2-thiouracil  (EXP)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
8-(4-chlorophenylthio)-cAMP  (ISO)
8-Br-cAMP  (EXP)
8-Epidiosbulbin E acetate  (ISO)
abietic acid  (EXP)
acadesine  (EXP)
acetamide  (EXP)
actinomycin D  (EXP,ISO)
aflatoxin B1  (ISO)
AICA ribonucleotide  (EXP)
aldehydo-D-glucose  (EXP)
alfacalcidol  (ISO)
all-trans-retinoic acid  (ISO)
allyl alcohol  (ISO)
alpha-amanitin  (ISO)
aluminium hydroxide  (EXP)
amiodarone  (EXP)
amphotericin B  (ISO)
ampicillin  (ISO)
angelicin  (EXP)
antimonite  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (EXP)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (ISO)
atazanavir sulfate  (ISO)
atorvastatin calcium  (EXP,ISO)
ATP  (EXP,ISO)
azathioprine  (EXP,ISO)
aztreonam  (ISO)
benzbromarone  (EXP,ISO)
benzo[a]pyrene  (ISO)
benzoylaconine  (ISO)
benzoylhypaconine  (ISO)
benzoylmesaconine  (ISO)
benzylpenicillin  (EXP,ISO)
beta-hexachlorocyclohexane  (ISO)
beta-naphthoflavone  (EXP,ISO)
bezafibrate  (ISO)
bilirubin IXalpha  (EXP)
biochanin A  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisdemethoxycurcumin  (ISO)
bisphenol A  (EXP,ISO)
Boldine  (EXP)
bortezomib  (ISO)
bosentan  (EXP,ISO)
bromfenac  (ISO)
bromosulfophthalein  (ISO)
bucladesine  (EXP,ISO)
buspirone  (EXP)
buta-1,3-diene  (ISO)
butanal  (ISO)
butylated hydroxyanisole  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calcein  (ISO)
calcein am  (EXP,ISO)
calcitriol  (EXP,ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
cannabidiol  (ISO)
captan  (ISO)
carbamazepine  (EXP,ISO)
carbon monoxide  (EXP)
carboplatin  (ISO)
carmustine  (ISO)
cefaloridine  (EXP)
cefalotin  (ISO)
celecoxib  (ISO)
cerivastatin  (ISO)
CGP 52608  (ISO)
chenodeoxycholic acid  (EXP,ISO)
chlorambucil  (ISO)
chlordecone  (ISO)
chlorogenic acid  (ISO)
chloroquine  (ISO)
chlorpromazine  (EXP,ISO)
chlorpyrifos  (ISO)
cholic acid  (ISO)
choline  (EXP,ISO)
chrysin  (ISO)
chrysophanol  (EXP)
ciprofloxacin  (ISO)
cisplatin  (EXP,ISO)
citalopram  (ISO)
clavulanic acid  (ISO)
clobazam  (EXP)
clofibrate  (EXP,ISO)
clofibric acid  (EXP)
clotrimazole  (ISO)
colforsin daropate hydrochloride  (ISO)
coniferyl aldehyde  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
curcumin  (ISO)
cyazofamid  (ISO)
cyclosporin A  (EXP,ISO)
cyproconazole  (EXP,ISO)
D-glucose  (EXP)
dapsone  (EXP)
daunorubicin  (ISO)
DDE  (ISO)
DDT  (ISO)
demethoxycurcumin  (ISO)
deoxycholic acid  (ISO)
desloratadine  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
Diallyl sulfide  (EXP)
diarsenic trioxide  (ISO)
diclofenac  (EXP,ISO)
dicrotophos  (ISO)
dieldrin  (ISO)
diethyl maleate  (ISO)
dimethylarsinic acid  (EXP)
Diosbulbin B  (ISO)
dioscin  (EXP)
diosgenin  (EXP)
dioxygen  (ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (EXP,ISO)
diquat  (ISO)
disodium selenite  (ISO)
doramapimod  (ISO)
dorsomorphin  (EXP)
dothiepin  (ISO)
doxorubicin  (EXP,ISO)
DPDPE  (EXP)
E3040  (ISO)
elemental selenium  (EXP,ISO)
emodin  (EXP,ISO)
endosulfan  (EXP,ISO)
enilconazole  (ISO)
epoxiconazole  (EXP)
Erucin  (ISO)
estrone 3-sulfate  (EXP,ISO)
etacrynic acid  (ISO)
ethambutol  (EXP)
ethoxyquin  (ISO)
etoposide  (ISO)
fenofibrate  (EXP)
Fexofenadine hydrochloride  (ISO)
fipronil  (EXP,ISO)
Fluo-3  (EXP)
flutamide  (EXP)
fluvastatin  (EXP,ISO)
formononetin  (EXP,ISO)
fosinopril  (ISO)
fructose  (EXP)
fulvestrant  (EXP,ISO)
furan  (EXP)
furosemide  (EXP,ISO)
fusidic acid  (EXP)
geneticin  (ISO)
genistein  (ISO)
gentamycin  (EXP)
geraniol  (EXP)
Ginkgolide A  (ISO)
ginkgolide B  (ISO)
ginsenoside Rb2  (EXP)
ginsenoside Re  (EXP,ISO)
ginsenoside Rg1  (EXP,ISO)
ginsenoside Rg2  (EXP)
glafenine  (EXP)
glucose  (EXP)
glutathione  (EXP,ISO)
glutathione disulfide  (EXP)
glyburide  (EXP,ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
glycyrrhetinate  (EXP)
glycyrrhetinic acid  (EXP)
glyphosate  (ISO)
Goe 6976  (EXP,ISO)
gold atom  (ISO)
gold(0)  (ISO)
guggulsterone  (ISO)
GW 4064  (EXP,ISO)
hepoxilin A3  (ISO)
heptachlor  (ISO)
Heptachlor epoxide  (ISO)
hexadecanoic acid  (ISO)
hydrogen peroxide  (ISO)
Hypaconitine  (ISO)
icariside II  (ISO)
imipenem hydrate  (ISO)
indole-3-methanol  (EXP)
indometacin  (EXP,ISO)
inulin  (ISO)
irinotecan  (ISO)
iron(III) nitrilotriacetate  (ISO)
isoniazide  (EXP)
ivermectin  (ISO)
JTE-013  (EXP)
ketoconazole  (EXP,ISO)
kojic acid  (EXP)
KT 5720  (EXP,ISO)
L-ascorbic acid  (EXP,ISO)
L-cysteine  (EXP,ISO)
L-methionine  (EXP,ISO)
leukotriene C4  (EXP,ISO)
levetiracetam  (EXP)
lipopolysaccharide  (EXP,ISO)
lithocholic acid  (EXP,ISO)
loperamide  (ISO)
lopinavir  (ISO)
loratadine  (ISO)
lovastatin  (EXP,ISO)
luteolin  (ISO)
LY294002  (ISO)
macitentan  (ISO)
manganese(II) chloride  (EXP)
Maprotiline  (EXP)
Meclizine  (ISO)
mercury atom  (EXP,ISO)
mercury dichloride  (EXP,ISO)
mercury(0)  (EXP,ISO)
Mesaconitine  (ISO)
metformin  (ISO)
methapyrilene  (EXP)
methidathion  (ISO)
methotrexate  (EXP,ISO)
methoxsalen  (ISO)
methylarsonic acid  (EXP,ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (EXP,ISO)
metiram  (ISO)
metronidazole  (ISO)
microcystin LF  (ISO)
microcystin RR  (ISO)
microcystin-LR  (ISO)
Midecamycin  (EXP,ISO)
mifepristone  (ISO)
MK 571  (EXP,ISO)
mono(2-ethylhexyl) phthalate  (ISO)
mono(glucosyluronic acid)bilirubin  (EXP,ISO)
monosodium L-glutamate  (ISO)
montelukast  (ISO)
Muraglitazar  (EXP)
myricetin  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP,ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-Acetyl-S-(1,2-dichlorovinyl)-cysteine  (ISO)
N-hydroxy-PhIP  (ISO)
N-nitrosodiethylamine  (EXP)
N-Vinyl-2-pyrrolidone  (EXP)
nelfinavir  (ISO)
neomycin  (ISO)
nifedipine  (EXP)
nimesulide  (EXP)
nitric oxide  (EXP,ISO)
nitrofen  (EXP)
nitrogen dioxide  (ISO)
nocodazole  (ISO)
norgestimate  (ISO)
notoginsenoside R1  (EXP,ISO)
Nutlin-3  (ISO)
obeticholic acid  (EXP,ISO)
ochratoxin A  (EXP,ISO)
oleanolic acid  (ISO)
olmesartan  (ISO)
oltipraz  (EXP,ISO)
omeprazole  (ISO)
organoselenium compound  (ISO)
orphenadrine  (EXP)
ortho-Aminoazotoluene  (ISO)
oxaliplatin  (ISO)
p-menthan-3-ol  (ISO)
paclitaxel  (ISO)
pantoprazole  (ISO)
paracetamol  (EXP,ISO)
parathion  (ISO)
paroxetine  (ISO)
PCB138  (ISO)
pentachlorophenol  (ISO)
perfluorobutyric acid  (ISO)
perfluorodecanoic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
perhexiline  (EXP)
phalloidin  (EXP)
phenethyl isothiocyanate  (ISO)
phenobarbital  (EXP,ISO)
phenol red  (EXP)
phenytoin  (EXP,ISO)
PhIP  (EXP,ISO)
phorbol 13-acetate 12-myristate  (EXP)
physcion  (EXP)
piperonyl butoxide  (ISO)
pirinixic acid  (EXP,ISO)
pitavastatin  (EXP,ISO)
pitavastatin(1-)  (EXP,ISO)
platinum  (ISO)
platinum(0)  (ISO)
pravastatin  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
probenecid  (EXP,ISO)
prochloraz  (EXP)
procymidone  (ISO)
progesterone  (ISO)
propane-1,2-diol  (ISO)
protein kinase inhibitor  (EXP)
prothioconazole  (ISO)
Prothioconazole-desthio  (ISO)
Prulifloxacin  (EXP)
psoralen  (EXP)
pyrazinecarboxamide  (EXP)
pyrrolidines  (EXP)
quercetin  (EXP,ISO)
reactive oxygen species  (EXP)
resveratrol  (EXP,ISO)
rifampicin  (EXP,ISO)
robinetin  (ISO)
rosuvastatin calcium  (EXP,ISO)
rotenone  (ISO)
rubitecan  (ISO)
S-(2,4-dinitrophenyl)glutathione  (EXP,ISO)
S-nitrosoglutathione  (EXP)
saquinavir  (ISO)
selenium atom  (EXP,ISO)
senecionine  (ISO)
sevoflurane  (EXP)
simvastatin  (EXP,ISO)
sincalide  (ISO)
sirolimus  (EXP)
sodium arsenate  (EXP,ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
sodium dichromate  (EXP,ISO)
sodium dodecyl sulfate  (ISO)
sodium hydrogencarbonate  (EXP)
sodium selenide  (ISO)
sorafenib  (ISO)
soybean oil  (EXP)
spironolactone  (EXP)
stilbene oxide  (EXP)
streptozocin  (EXP,ISO)
succimer  (EXP,ISO)
sulfasalazine  (EXP)
sulfinpyrazone  (ISO)
sulforaphane  (EXP,ISO)
sunitinib  (EXP)
Sunset Yellow FCF  (ISO)
tamoxifen  (EXP,ISO)
Tanshinone I  (ISO)
tartrazine  (ISO)
taurine  (EXP)
tauro-beta-muricholic acid  (EXP)
taurochenodeoxycholic acid  (EXP)
taurocholic acid  (EXP,ISO)
taurolithocholic acid  (EXP)
tauroursodeoxycholic acid  (EXP)
tectorigenin  (ISO)
Temocaprilat  (EXP)
temozolomide  (ISO)
tert-butyl hydroperoxide  (EXP,ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP)
texas red  (EXP)
thiacloprid  (ISO)
thioacetamide  (EXP)
thiophanate-methyl  (ISO)
thyroxine  (EXP)
Thyroxine glucuronide  (EXP)
tiagabine  (EXP)
tianeptine  (EXP)
ticlopidine  (EXP,ISO)
titanium dioxide  (ISO)
tolvaptan  (ISO)
topiramate  (EXP)
topotecan  (ISO)
trans-piceid  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
trimethylarsine oxide  (EXP)
triphenyl phosphate  (EXP)
triptonide  (ISO)
troglitazone  (ISO)
tyrphostin AG 1478  (EXP)
uranium atom  (EXP)
urethane  (ISO)
ursodeoxycholic acid  (EXP,ISO)
vadimezan  (ISO)
valdecoxib  (EXP)
valproic acid  (EXP,ISO)
vancomycin  (EXP,ISO)
verapamil  (ISO)
vincaleukoblastine  (EXP,ISO)
vincristine  (ISO)
vitamin E  (EXP)
wortmannin  (EXP)
Y-27632  (ISO)
Yangonin  (ISO)
yohimbine  (ISO)
zearalenone  (ISO)
ziram  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
antibiotic metabolic process  (IMP)
benzylpenicillin metabolic process  (IMP)
bile acid and bile salt transport  (IEA,IEP,ISO,ISS)
bile acid signaling pathway  (IEP)
bilirubin transport  (IEA,IMP,ISO)
canalicular bile acid transport  (IMP)
cellular response to dexamethasone stimulus  (IEP)
cellular response to interleukin-1  (IEP)
cellular response to interleukin-6  (IEP)
cellular response to lipopolysaccharide  (IEP)
cellular response to tumor necrosis factor  (IEP)
cellular response to xenobiotic stimulus  (IEP)
detoxification of mercury ion  (IMP)
female pregnancy  (IEP)
intracellular chloride ion homeostasis  (IDA)
leukotriene transport  (IEA,IMP,ISO)
mercury ion transport  (IMP)
negative regulation of gene expression  (IMP)
organic anion transport  (IMP,TAS)
prostaglandin transport  (IMP)
regulation of bile acid secretion  (IEP)
response to antineoplastic agent  (IEP)
response to arsenic-containing substance  (IEP)
response to estradiol  (IEP)
response to estrogen  (IDA,IEP)
response to glucagon  (IEP)
response to lipopolysaccharide  (IEP)
response to organic cyclic compound  (IEP)
response to oxidative stress  (IEP)
response to steroid hormone  (IEP)
response to xenobiotic stimulus  (IDA)
thyroid hormone transport  (IMP)
transepithelial transport  (IGI,IMP)
transmembrane transport  (IBA,IEA)
xenobiotic catabolic process  (IMP)
xenobiotic detoxification by transmembrane export across the plasma membrane  (IMP)
xenobiotic export from cell  (IEA,ISO)
xenobiotic transmembrane transport  (IEA,IMP,ISO)
xenobiotic transport across blood-brain barrier  (IGI,IMP)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Involvement of multidrug resistance-associated protein 2 (ABCC2/Mrp2) in biliary excretion of micafungin in rats. Abe F, etal., Life Sci. 2008 Aug 15;83(7-8):229-35. doi: 10.1016/j.lfs.2008.06.013. Epub 2008 Jul 1.
2. Involvement of Mrp2 (Abcc2) in biliary excretion of moxifloxacin and its metabolites in the isolated perfused rat liver. Ahmed S, etal., J Pharm Pharmacol. 2008 Jan;60(1):55-62. doi: 10.1211/jpp.60.1.0007.
3. Glucagon-like peptide 2 prevents down-regulation of intestinal multidrug resistance-associated protein 2 and P-glycoprotein in endotoxemic rats. Arana MR, etal., Toxicology. 2017 Sep 1;390:22-31. doi: 10.1016/j.tox.2017.08.007. Epub 2017 Aug 23.
4. Regulation of expression and activity of rat intestinal multidrug resistance-associated protein 2 by cholestatic estrogens. Arias A, etal., Drug Metab Dispos. 2009 Jun;37(6):1277-85. doi: 10.1124/dmd.108.025643. Epub 2009 Mar 19.
5. Clinical impact of ABCC1 and ABCC2 genotypes and haplotypes in mediating imatinib resistance among chronic myeloid leukaemia patients. Au A, etal., J Clin Pharm Ther. 2014 Dec;39(6):685-90. doi: 10.1111/jcpt.12197. Epub 2014 Jul 24.
6. Adenosine triphosphate-binding cassette subfamily C member 2 is the major transporter of the hepatobiliary imaging agent (99m)Tc-mebrofenin. Bhargava KK, etal., J Nucl Med. 2009 Jul;50(7):1140-6. doi: 10.2967/jnumed.109.062448. Epub 2009 Jun 12.
7. Heat stress enhances recovery of hepatocyte bile acid and organic anion transporters in endotoxemic rats by multiple mechanisms. Bolder U, etal., Cell Stress Chaperones. 2006 Spring;11(1):89-100.
8. Quantification of drug transport function across the multiple resistance-associated protein 2 (Mrp2) in rat livers. Bonnaventure P and Pastor CM, Int J Mol Sci. 2014 Dec 24;16(1):135-47. doi: 10.3390/ijms16010135.
9. Placental and fetal disposition of mercuric ions in rats exposed to methylmercury: role of Mrp2. Bridges CC, etal., Reprod Toxicol. 2012 Dec;34(4):628-34. doi: 10.1016/j.reprotox.2012.10.001. Epub 2012 Oct 8.
10. MRP2 and the handling of mercuric ions in rats exposed acutely to inorganic and organic species of mercury. Bridges CC, etal., Toxicol Appl Pharmacol. 2011 Feb 15;251(1):50-8. doi: 10.1016/j.taap.2010.11.015. Epub 2010 Dec 4.
11. cDNA cloning of the hepatocyte canalicular isoform of the multidrug resistance protein, cMrp, reveals a novel conjugate export pump deficient in hyperbilirubinemic mutant rats. Buchler M, etal., J Biol Chem 1996 Jun 21;271(25):15091-8.
12. ATP8B1 deficiency disrupts the bile canalicular membrane bilayer structure in hepatocytes, but FXR expression and activity are maintained. Cai SY, etal., Gastroenterology. 2009 Mar;136(3):1060-9. doi: 10.1053/j.gastro.2008.10.025. Epub 2008 Nov 1.
13. Drug-metabolizing enzyme and transporter expression in a mouse model of diabetes and obesity. Cheng Q, etal., Mol Pharm. 2008 Jan-Feb;5(1):77-91. Epub 2008 Jan 12.
14. MRP2 haplotypes confer differential susceptibility to toxic liver injury. Choi JH, etal., Pharmacogenet Genomics. 2007 Jun;17(6):403-15. doi: 10.1097/01.fpc.0000236337.41799.b3.
15. Involvement of Mrp2/MRP2 in the species different excretion route of benzylpenicillin between rat and human. Choi MK, etal., Xenobiotica. 2009 Feb;39(2):171-81. doi: 10.1080/00498250802642256.
16. Estradiol-17beta-D-glucuronide induces endocytic internalization of Bsep in rats. Crocenzi FA, etal., Am J Physiol Gastrointest Liver Physiol. 2003 Aug;285(2):G449-59. Epub 2003 Apr 17.
17. Drug resistance and ATP-dependent conjugate transport mediated by the apical multidrug resistance protein, MRP2, permanently expressed in human and canine cells. Cui Y, etal., Mol Pharmacol. 1999 May;55(5):929-37.
18. Genetic susceptibility to diclofenac-induced hepatotoxicity: contribution of UGT2B7, CYP2C8, and ABCC2 genotypes. Daly AK, etal., Gastroenterology. 2007 Jan;132(1):272-81. doi: 10.1053/j.gastro.2006.11.023. Epub 2006 Nov 17.
19. Multidrug resistance associated protein 2 mediates transport of prostaglandin E2. de Waart DR, etal., Liver Int. 2006 Apr;26(3):362-8.
20. Regulation of MRP2/ABCC2 and BSEP/ABCB11 expression in sandwich cultured human and rat hepatocytes exposed to inflammatory cytokines TNF-{alpha}, IL-6, and IL-1{beta}. Diao L, etal., J Biol Chem. 2010 Oct 8;285(41):31185-92. doi: 10.1074/jbc.M110.107805. Epub 2010 Aug 11.
21. Consequences of bile duct obstruction on intestinal expression and function of multidrug resistance-associated protein 2. Dietrich CG, etal., Gastroenterology. 2004 Apr;126(4):1044-53.
22. [Effects of MRP2-GSH cotransport system on hepatic arsenic metabolism in rats] Gao Y, etal., Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2006 May;24(5):278-80.
23. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
24. Characterization of organic anion transporter regulation, glutathione metabolism and bile formation in the obese Zucker rat. Geier A, etal., J Hepatol. 2005 Dec;43(6):1021-30. Epub 2005 Jul 1.
25. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
26. Association of ABCC2 polymorphisms with platinum-based chemotherapy response and severe toxicity in non-small cell lung cancer patients. Han B, etal., Lung Cancer. 2011 May;72(2):238-43. doi: 10.1016/j.lungcan.2010.09.001. Epub 2010 Oct 12.
27. Associations of ABCB1, ABCC2, and ABCG2 polymorphisms with irinotecan-pharmacokinetics and clinical outcome in patients with advanced non-small cell lung cancer. Han JY, etal., Cancer. 2007 Jul 1;110(1):138-47.
28. The pharmacokinetics of morphine and its glucuronide conjugate in a rat model of streptozotocin-induced diabetes and the expression of MRP2, MRP3 and UGT2B1 in the liver. Hasegawa Y, etal., J Pharm Pharmacol. 2010 Mar;62(3):310-4. doi: 10.1211/jpp.62.03.0004.
29. Treatment of hyperbilirubinemia in Eisai hyperbilirubinemic rat by transfecting human MRP2/ABCC2 gene. Hirouchi M, etal., Pharm Res. 2005 Apr;22(4):661-6. Epub 2005 Apr 7.
30. Association of the c.3972C>T variant of the multidrug resistance-associated protein 2 Gene (MRP2/ABCC2) with susceptibility to bile duct cancer. Hoblinger A, etal., Digestion. 2009;80(1):36-9. Epub 2009 May 19.
31. Upregulation of brain expression of P-glycoprotein in MRP2-deficient TR(-) rats resembles seizure-induced up-regulation of this drug efflux transporter in normal rats. Hoffmann K and Löscher W, Epilepsia. 2007 Apr;48(4):631-45. doi: 10.1111/j.1528-1167.2006.00939.x.
32. Expression of the multidrug transporter MRP2 in the blood-brain barrier after pilocarpine-induced seizures in rats. Hoffmann K, etal., Epilepsy Res. 2006 Apr;69(1):1-14. Epub 2006 Feb 28.
33. Single amino acid substitution of rat MRP2 results in acquired transport activity for taurocholate. Ito K, etal., Am J Physiol Gastrointest Liver Physiol 2001 Oct;281(4):G1034-43.
34. The role of protein synthesis and degradation in the post-transcriptional regulation of rat multidrug resistance-associated protein 2 (Mrp2, Abcc2). Jones BR, etal., Mol Pharmacol. 2005 Sep;68(3):701-10. Epub 2005 May 25.
35. Transport of monoglucuronosyl and bisglucuronosyl bilirubin by recombinant human and rat multidrug resistance protein 2. Kamisako T, etal., Hepatology. 1999 Aug;30(2):485-90. doi: 10.1002/hep.510300220.
36. Prospective evaluation of the drug-metabolizing enzyme polymorphisms and toxicity profile of docetaxel in Korean patients with operable lymph node-positive breast cancer receiving adjuvant chemotherapy. Kim KP, etal., Cancer Chemother Pharmacol. 2012 May;69(5):1221-7. doi: 10.1007/s00280-011-1816-4. Epub 2012 Jan 20.
37. Differences in the pharmacokinetics of peroxisome proliferator-activated receptor agonists in genetically obese Zucker and sprague-dawley rats: implications of decreased glucuronidation in obese Zucker rats. Kim MS, etal., Drug Metab Dispos. 2004 Sep;32(9):909-14.
38. Polymorphisms in drug transporter genes (ABCB1, SLCO1B1 and ABCC2) and hepatitis induced by antituberculosis drugs. Kim SH, etal., Tuberculosis (Edinb). 2012 Jan;92(1):100-4. doi: 10.1016/j.tube.2011.09.007. Epub 2011 Dec 16.
39. Association of genetic polymorphisms in SLCO1B3 and ABCC2 with docetaxel-induced leukopenia. Kiyotani K, etal., Cancer Sci. 2008 May;99(5):967-72. doi: 10.1111/j.1349-7006.2008.00765.x. Epub 2008 Feb 19.
40. Increased plasma post-heparin diamine oxidase activity and plant sterol levels in streptozotocin diabetic rat. Kojima H, etal., Biochem Biophys Res Commun. 1992 Jul 15;186(1):398-404.
41. Key determinants of the circulatory exposure of organic anions: differences in hepatic uptake between multidrug resistance-associated protein 2 (Mrp2)-deficient rats and wild-type rats. Kosaka K, etal., Xenobiotica. 2015;45(6):556-62. doi: 10.3109/00498254.2014.997820. Epub 2014 Dec 24.
42. Hepatobiliary disposition of thyroid hormone in Mrp2-deficient TR- rats: reduced biliary excretion of thyroxine glucuronide does not prevent xenobiotic-induced hypothyroidism. Lecureux L, etal., Toxicol Sci. 2009 Apr;108(2):482-91. Epub 2009 Feb 11.
43. The relationship of polymorphisms in ABCC2 and SLCO1B3 with docetaxel pharmacokinetics and neutropenia: CALGB 60805 (Alliance). Lewis LD, etal., Pharmacogenet Genomics. 2013 Jan;23(1):29-33. doi: 10.1097/FPC.0b013e32835b16d8.
44. NHERF-1 binds to Mrp2 and regulates hepatic Mrp2 expression and function. Li M, etal., J Biol Chem. 2010 Jun 18;285(25):19299-307. doi: 10.1074/jbc.M109.096081. Epub 2010 Apr 19.
45. Mrp2 modulates the activity of chloride channels in isolated hepatocytes. Li X and Weinman SA, Hepatology. 2002 Jul;36(1):65-71.
46. Role of AMP-activated protein kinase α1 in 17α-ethinylestradiol-induced cholestasis in rats. Li X, etal., Arch Toxicol. 2017 Jan;91(1):481-494. doi: 10.1007/s00204-016-1697-8. Epub 2016 Apr 18.
47. Association of ABCC2 -24C>T polymorphism with high-dose methotrexate plasma concentrations and toxicities in childhood acute lymphoblastic leukemia. Liu Y, etal., PLoS One. 2014 Jan 3;9(1):e82681. doi: 10.1371/journal.pone.0082681. eCollection 2014.
48. Functional induction of P-glycoprotein in the blood-brain barrier of streptozotocin-induced diabetic rats: evidence for the involvement of nuclear factor-kappaB, a nitrosative stress-sensitive transcription factor, in the regulation. Maeng HJ, etal., Drug Metab Dispos. 2007 Nov;35(11):1996-2005. Epub 2007 Jul 30.
49. 4-Hydroxyacetophenone-induced choleresis in rats is mediated by the Mrp2-dependent biliary secretion of its glucuronide conjugate. Mahagita C, etal., Pharm Res. 2006 Nov;23(11):2603-10. Epub 2006 Sep 29.
50. Metabolism and disposition of acetaminophen: recent advances in relation to hepatotoxicity and diagnosis. McGill MR and Jaeschke H, Pharm Res. 2013 Sep;30(9):2174-87. doi: 10.1007/s11095-013-1007-6. Epub 2013 Mar 6.
51. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
52. Zonation of multidrug resistance-associated protein 2 in rat liver after induction with dexamethasone. Micuda S, etal., J Gastroenterol Hepatol. 2008 Jul;23(7 Pt 2):e225-30. Epub 2007 Aug 6.
53. Correlation between apical localization of Abcc2/Mrp2 and phosphorylation status of ezrin in rat intestine. Nakano T, etal., Drug Metab Dispos. 2009 Jul;37(7):1521-7. Epub 2009 Apr 1.
54. Down-regulation of intestinal drug transporters in chronic renal failure in rats. Naud J, etal., J Pharmacol Exp Ther. 2007 Mar;320(3):978-85. Epub 2006 Nov 29.
55. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
56. Expression of multidrug resistance-associated protein 2 is involved in chemotherapy resistance in human pancreatic cancer. Noma B, etal., Int J Oncol. 2008 Dec;33(6):1187-94.
57. Increased apical insertion of the multidrug resistance protein 2 (MRP2/ABCC2) in renal proximal tubules following gentamicin exposure. Notenboom S, etal., J Pharmacol Exp Ther. 2006 Sep;318(3):1194-202. Epub 2006 Jun 6.
58. Renal and hepatic transporter expression in type 2 diabetic rats. Nowicki MT, etal., Drug Metab Lett. 2008 Jan;2(1):11-7.
59. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
60. Congenital jaundice in rats with a mutation in a multidrug resistance-associated protein gene. Paulusma CC, etal., Science 1996 Feb 23;271(5252):1126-8.
61. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
62. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
63. Magnetic resonance imaging with hepatospecific contrast agents in cirrhotic rat livers. Planchamp C, etal., Invest Radiol. 2005 Apr;40(4):187-94.
64. Multidrug resistance protein MRP2 contributes to blood-brain barrier function and restricts antiepileptic drug activity. Potschka H, etal., J Pharmacol Exp Ther 2003 Jul;306(1):124-31.
65. GOA pipeline RGD automated data pipeline
66. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
67. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
68. Oxidative stress and Mrp2 internalization. Sekine S, etal., Free Radic Biol Med. 2006 Jun 15;40(12):2166-74. Epub 2006 Mar 13.
69. Effect of 5-fluorouracil treatment on SN-38 absorption from intestine in rats. Shibayama Y, etal., Biol Pharm Bull. 2011;34(9):1418-25.
70. Effect of methotrexate treatment on expression levels of multidrug resistance protein 2, breast cancer resistance protein and organic anion transporters Oat1, Oat2 and Oat3 in rats. Shibayama Y, etal., Cancer Sci. 2006 Nov;97(11):1260-6. Epub 2006 Aug 22.
71. Polymorphisms of MRP2 (ABCC2) are associated with susceptibility to nonalcoholic fatty liver disease. Sookoian S, etal., J Nutr Biochem. 2009 Oct;20(10):765-70. doi: 10.1016/j.jnutbio.2008.07.005. Epub 2008 Oct 15.
72. The Chinese Herb Jianpijiedu Contributes to the Regulation of OATP1B2 and ABCC2 in a Rat Model of Orthotopic Transplantation Liver Cancer Pretreated with Food Restriction and Diarrhea. Sun B, etal., Biomed Res Int. 2015;2015:752850. doi: 10.1155/2015/752850. Epub 2015 Nov 17.
73. Gender-related differences in expression and function of hepatic P-glycoprotein and multidrug resistance-associated protein (Mrp2) in rats. Suzuki T, etal., Life Sci. 2006 Jun 27;79(5):455-61. Epub 2006 Feb 17.
74. Increased renal expression of bilirubin glucuronide transporters in a rat model of obstructive jaundice. Tanaka Y, etal., Am J Physiol Gastrointest Liver Physiol 2002 Apr;282(4):G656-62.
75. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
76. Doxorubicin pathways: pharmacodynamics and adverse effects. Thorn CF, etal., Pharmacogenet Genomics. 2011 Jul;21(7):440-6. doi: 10.1097/FPC.0b013e32833ffb56.
77. Genomic structure of the canalicular multispecific organic anion-transporter gene (MRP2/cMOAT) and mutations in the ATP-binding-cassette region in Dubin-Johnson syndrome. Toh S, etal., Am J Hum Genet. 1999 Mar;64(3):739-46.
78. Messenger RNA profiles in liver injury and stress: a comparison of lethal and nonlethal rat models. Tygstrup N, etal., Biochem Biophys Res Commun 2002 Jan 11;290(1):518-25.
79. Mutations in the canilicular multispecific organic anion transporter (cMOAT) gene, a novel ABC transporter, in patients with hyperbilirubinemia II/Dubin-Johnson syndrome. Wada M, etal., Hum Mol Genet. 1998 Feb;7(2):203-7. doi: 10.1093/hmg/7.2.203.
80. Decreased exposure of simvastatin and simvastatin acid in a rat model of type 2 diabetes. Xu D, etal., Acta Pharmacol Sin. 2014 Sep;35(9):1215-25. doi: 10.1038/aps.2014.39. Epub 2014 Aug 25.
81. Function of multidrug resistance-associated protein 2 in acute hepatic failure rats. Yokooji T, etal., Eur J Pharmacol. 2006 Sep 28;546(1-3):152-60. Epub 2006 Jul 5.
82. Characterization of SAGE Mdr1a (P-gp), Bcrp, and Mrp2 knockout rats using loperamide, paclitaxel, sulfasalazine, and carboxydichlorofluorescein pharmacokinetics. Zamek-Gliszczynski MJ, etal., Drug Metab Dispos. 2012 Sep;40(9):1825-33. doi: 10.1124/dmd.112.046508. Epub 2012 Jun 18.
83. Differential involvement of Mrp2 (Abcc2) and Bcrp (Abcg2) in biliary excretion of 4-methylumbelliferyl glucuronide and sulfate in the rat. Zamek-Gliszczynski MJ, etal., J Pharmacol Exp Ther. 2006 Oct;319(1):459-67. Epub 2006 Jul 20.
84. Genetic polymorphisms in candidate genes predict increased toxicity with methotrexate therapy in Lebanese children with acute lymphoblastic leukemia. Zgheib NK, etal., Pharmacogenet Genomics. 2014 Aug;24(8):387-96. doi: 10.1097/FPC.0000000000000069.
85. Experimental LPS-induced cholestasis alters subcellular distribution and affects colocalization of Mrp2 and Bsep proteins: a quantitative colocalization study. Zinchuk V, etal., Microsc Res Tech. 2005 Jun 1;67(2):65-70.
86. Alterations of canalicular ATP-binding cassette transporter expression in drug-induced liver injury. Zollner G, etal., Digestion. 2014;90(2):81-8. doi: 10.1159/000365003. Epub 2014 Sep 4.
Additional References at PubMed
PMID:7559771   PMID:9571149   PMID:11093739   PMID:11279518   PMID:11500505   PMID:12068294   PMID:12538788   PMID:12623073   PMID:12883478   PMID:12951053   PMID:13678533   PMID:14636316  
PMID:14724430   PMID:15057914   PMID:15374814   PMID:15504935   PMID:15816878   PMID:16332456   PMID:16537972   PMID:16946557   PMID:17038627   PMID:17065236   PMID:17234897   PMID:17384956  
PMID:17463180   PMID:17467962   PMID:17615179   PMID:17724374   PMID:17825285   PMID:17959626   PMID:17963604   PMID:18159133   PMID:18175959   PMID:18378562   PMID:18538350   PMID:18662814  
PMID:18687803   PMID:18700187   PMID:19010343   PMID:19063911   PMID:19074644   PMID:19156843   PMID:19214140   PMID:19541926   PMID:19581412   PMID:19656454   PMID:19703566   PMID:19944137  
PMID:20676911   PMID:20738239   PMID:20868650   PMID:21131269   PMID:21198435   PMID:21660137   PMID:22057277   PMID:22330094   PMID:22361279   PMID:22446938   PMID:22472606   PMID:22576625  
PMID:22579010   PMID:22613706   PMID:22812007   PMID:22925079   PMID:22992436   PMID:23041646   PMID:23096566   PMID:23125159   PMID:23146761   PMID:23442774   PMID:23562342   PMID:23569176  
PMID:25200138   PMID:25813982   PMID:26053941   PMID:26244301   PMID:26254357   PMID:26646631   PMID:27237619   PMID:27780379   PMID:28298215   PMID:29052767   PMID:30068870   PMID:32476256  
PMID:34303734  


Genomics

Comparative Map Data
Abcc2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21242,664,657 - 242,723,239 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1242,664,657 - 242,723,238 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1250,813,581 - 250,872,198 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01257,510,469 - 257,569,198 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01250,163,726 - 250,222,340 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01263,554,426 - 263,612,556 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1263,554,453 - 263,613,252 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01270,999,832 - 271,057,750 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1238,483,399 - 238,539,595 (+)NCBICelera
Cytogenetic Map1q54NCBI
ABCC2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381099,782,640 - 99,852,594 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1099,782,640 - 99,852,594 (+)EnsemblGRCh38hg38GRCh38
GRCh3710101,542,397 - 101,612,351 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3610101,532,493 - 101,601,571 (+)NCBINCBI36Build 36hg18NCBI36
Build 3410101,532,562 - 101,601,571NCBI
Celera1095,279,806 - 95,349,643 (+)NCBICelera
Cytogenetic Map10q24.2NCBI
HuRef1095,169,835 - 95,239,503 (+)NCBIHuRef
CHM1_110101,824,911 - 101,894,368 (+)NCBICHM1_1
T2T-CHM13v2.010100,665,562 - 100,736,331 (+)NCBIT2T-CHM13v2.0
Abcc2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391943,770,747 - 43,826,771 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1943,770,631 - 43,829,179 (+)EnsemblGRCm39 Ensembl
GRCm381943,782,308 - 43,838,332 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1943,782,192 - 43,840,740 (+)EnsemblGRCm38mm10GRCm38
MGSCv371943,856,798 - 43,912,708 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361943,835,715 - 43,891,248 (+)NCBIMGSCv36mm8
Celera1944,567,463 - 44,621,438 (+)NCBICelera
Cytogenetic Map19C3NCBI
cM Map1936.67NCBI
Abcc2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555075,724,762 - 5,790,812 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555075,724,788 - 5,791,281 (+)NCBIChiLan1.0ChiLan1.0
ABCC2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan110111,688,214 - 111,755,876 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01096,385,534 - 96,458,571 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11099,889,021 - 99,947,452 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1099,889,160 - 99,947,270 (+)Ensemblpanpan1.1panPan2
ABCC2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12812,670,885 - 12,740,124 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2812,670,885 - 12,740,740 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2812,854,192 - 12,923,368 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02813,138,667 - 13,208,016 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2813,138,667 - 13,208,633 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12812,685,440 - 12,754,683 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02812,716,120 - 12,786,599 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02812,857,984 - 12,927,300 (+)NCBIUU_Cfam_GSD_1.0
Abcc2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721334,253,163 - 34,302,933 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936636292,709 - 340,393 (-)EnsemblSpeTri2.0
SpeTri2.0NW_004936636292,631 - 341,999 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ABCC2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14110,955,633 - 111,037,537 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114110,955,698 - 111,038,898 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214120,400,787 - 120,484,137 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ABCC2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1992,826,423 - 92,902,389 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl992,841,818 - 92,902,265 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604853,844,985 - 53,909,244 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Abcc2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473711,593,864 - 11,688,460 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473711,593,701 - 11,686,790 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Abcc2
226 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:27
Count of miRNA genes:27
Interacting mature miRNAs:27
Transcripts:ENSRNOT00000070861
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1150700142252085212Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1150700247252085048Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1156677124256448636Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393243914901Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1176426412257976495Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1177227632256448636Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1177227632256448636Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1179567751260522016Rat
8655655Arrd2Age-related retinal degeneration QTL 27.79retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1183970203243914901Rat
8655855Arrd3Age-related retinal degeneration QTL 33.07lens clarity trait (VT:0001304)cataract incidence/prevalence measurement (CMO:0001585)1183970203243914901Rat
1358898Bp255Blood pressure QTL 2553.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1191019702246062233Rat
1358191Ept10Estrogen-induced pituitary tumorigenesis QTL 103.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)1192825253243914732Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1195804352257091168Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
1600374Mcs17Mammary carcinoma susceptibility QTL 173mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1197670404242670404Rat
2302375Bw83Body weight QTL 834.870.0002body mass (VT:0001259)body weight (CMO:0000012)1197697768242697768Rat
61376Bp42Blood pressure QTL 4223.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1197814409242814409Rat
1298084Thym4Thymus enlargement QTL 410.68thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1197814409242814409Rat
1357335Bw39Body weight QTL 393.3body mass (VT:0001259)body weight (CMO:0000012)1197814409242814409Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1199050459259647894Rat
2293694Bss38Bone structure and strength QTL 387.050.0001femur strength trait (VT:0010010)femur stiffness (CMO:0001674)1201554356246554356Rat
7394701Uae46Urinary albumin excretion QTL 463.60.0056urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1201554356246554356Rat
2300175Bmd40Bone mineral density QTL 4015.40.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)1201554356246554356Rat
2293655Bss36Bone structure and strength QTL 3610.660.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1201554356246554356Rat
2293674Bss39Bone structure and strength QTL 397.10.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)1201554356246554356Rat
10059587Bw173Body weight QTL 1733.230.025body mass (VT:0001259)body weight (CMO:0000012)1202069611247069611Rat
1600363Hc6Hypercalciuria QTL 62.7urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1203995416244113296Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1206081677251081677Rat
1357399Bw45Body weight QTL 453.05body mass (VT:0001259)body mass index (BMI) (CMO:0000105)1206329708251329708Rat
1357404Bw42Body weight QTL 424.490.0001body mass (VT:0001259)body weight (CMO:0000012)1206329708251329708Rat
1358890Bp259Blood pressure QTL 2593.06arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1210702053260522016Rat
2292216Bw80Body weight QTL 803.230.0019body mass (VT:0001259)body weight (CMO:0000012)1213533809243914901Rat
724538Kidm1Kidney mass QTL 13.2kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1213707201252085212Rat
734768Niddm59Non-insulin dependent diabetes mellitus QTL 59body mass (VT:0001259)body weight (CMO:0000012)1213843987258843987Rat
70211Niddm24Non-insulin dependent diabetes mellitus QTL 243.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1214647894259647894Rat
1549910Bw54Body weight QTL 540.05body mass (VT:0001259)body weight (CMO:0000012)1214647894259647894Rat
61327Eae7Experimental allergic encephalomyelitis QTL 75.6body mass (VT:0001259)change in body weight (CMO:0002045)1216255568260522016Rat
2302040Pia35Pristane induced arthritis QTL 353.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1216255568260522016Rat
1598821Rf55Renal function QTL 556.3renal blood flow trait (VT:2000006)ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)1218748008257976495Rat
61400Niddm1Non-insulin dependent diabetes mellitus QTL 111blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1218753689245907899Rat
724533Rf51Renal function QTL 515.30.0002kidney plasma flow trait (VT:0005524)renal plasma flow (CMO:0001914)1218753816256448513Rat
731175Uae20Urinary albumin excretion QTL 203.50.0018urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1221264111259647894Rat
10053715Scort24Serum corticosterone level QTL 242.130.0088blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1221414816260522016Rat
724552Glom2Glomerulus QTL 23.30.0001kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)1222363780260522016Rat
1600392Bw123Body weight QTL 1230.001body mass (VT:0001259)body weight (CMO:0000012)1223201027260522016Rat
2293700Bmd27Bone mineral density QTL 276.60.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1224054293243747962Rat
2293701Bmd34Bone mineral density QTL 348.30.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)1224054293243747962Rat
734767Niddm57Non-insulin dependent diabetes mellitus QTL 57body mass (VT:0001259)body weight (CMO:0000012)1224054293260122809Rat
631843Bw116Body weight QTL 1164.10.016abdominal adipose amount (VT:1000220)abdominal fat pad weight (CMO:0000088)1224054293260122809Rat
734769Niddm58Non-insulin dependent diabetes mellitus QTL 58body mass (VT:0001259)body weight (CMO:0000012)1224569538260122809Rat
631215Stl8Serum triglyceride level QTL 89.270.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1225126575260522016Rat
1300108Rf8Renal function QTL 83.75renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)1228581588259647894Rat
2316896Gluco57Glucose level QTL 577.2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1228985440245907899Rat
1581544Rf52Renal function QTL 520.05urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)1232156370259647894Rat
631669Iddm9Insulin dependent diabetes mellitus QTL 92.80.039blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1233190394258625266Rat
631536Lnnr2Liver neoplastic nodule remodeling QTL 22.90.0005liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)1233948574260522016Rat
631690Scl5Serum cholesterol level QTL 52.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1236125214260522016Rat
631836Stl31Serum triglyceride level QTL 314.640.00000487blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1237147813260522016Rat
631837Niddm35Non-insulin dependent diabetes mellitus QTL 350.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1238699859259647894Rat

Markers in Region
RH138478  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21242,722,900 - 242,723,106 (+)MAPPERmRatBN7.2
Rnor_6.01263,612,218 - 263,612,423NCBIRnor6.0
Rnor_5.01271,057,427 - 271,057,632UniSTSRnor5.0
Celera1238,539,257 - 238,539,462UniSTS
RH 3.4 Map11618.32UniSTS
Cytogenetic Map1q51UniSTS


Related Rat Strains
The following Strains have been annotated to Abcc2
WUN-Abcc2TR-/HsdRrrc    


Genetic Models
This gene Abcc2 is modified in the following models/strains:
SD-Abcc2em1Sage     WUN-Abcc2TR-/HsdRrrc    


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 37 37 37 7
Low 2 19 4 11 4 2 2 64 24 13 11 2
Below cutoff 1 41 1 8 6 8 10 4 27 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000070861   ⟹   ENSRNOP00000064799
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1242,664,657 - 242,723,238 (+)Ensembl
Rnor_6.0 Ensembl1263,554,453 - 263,613,252 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000107279   ⟹   ENSRNOP00000082829
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1242,666,026 - 242,723,238 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000118317   ⟹   ENSRNOP00000088095
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1242,664,657 - 242,718,639 (+)Ensembl
RefSeq Acc Id: NM_012833   ⟹   NP_036965
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21242,664,657 - 242,723,239 (+)NCBI
Rnor_6.01263,554,426 - 263,612,556 (+)NCBI
Rnor_5.01270,999,832 - 271,057,750 (+)NCBI
Celera1238,483,399 - 238,539,595 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_036965   ⟸   NM_012833
- UniProtKB: Q63145 (UniProtKB/Swiss-Prot),   Q63120 (UniProtKB/Swiss-Prot),   A0A8I6G7X8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000064799   ⟸   ENSRNOT00000070861
RefSeq Acc Id: ENSRNOP00000082829   ⟸   ENSRNOT00000107279
RefSeq Acc Id: ENSRNOP00000088095   ⟸   ENSRNOT00000118317
Protein Domains
ABC transmembrane type-1   ABC transporter

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63120-F1-model_v2 AlphaFold Q63120 1-1541 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690930
Promoter ID:EPDNEW_R1454
Type:initiation region
Name:Abcc2_1
Description:ATP binding cassette subfamily C member 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01263,554,541 - 263,554,601EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2366 AgrOrtholog
BioCyc Gene G2FUF-55618 BioCyc
Ensembl Genes ENSRNOG00000046727 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000070861 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000107279.1 UniProtKB/TrEMBL
  ENSRNOT00000118317.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1560.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AAA+_ATPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC1_TM_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC1_TM_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC_transporter-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC_transporter-like_CS UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
  Multidrug-R_assoc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25303 UniProtKB/Swiss-Prot
NCBI Gene 25303 ENTREZGENE
PANTHER ATP-BINDING CASSETTE SUB-FAMILY C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR24223:SF176 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ABC_membrane UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC_tran UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB ABCC2 RGD
PhenoGen Abcc2 PhenoGen
PROSITE ABC_TM1F UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC_TRANSPORTER_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC_TRANSPORTER_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000046727 RatGTEx
SMART AAA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF90123 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC208681
UniProt A0A8I6A8L8_RAT UniProtKB/TrEMBL
  A0A8I6G7X8 ENTREZGENE, UniProtKB/TrEMBL
  MRP2_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q63145 ENTREZGENE
UniProt Secondary Q63145 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-02 Abcc2  ATP binding cassette subfamily C member 2  Abcc2  ATP-binding cassette, subfamily C (CFTR/MRP), member 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-11-16 Abcc2  ATP-binding cassette, subfamily C (CFTR/MRP), member 2  Abcc2  ATP-binding cassette, sub-family C (CFTR/MRP), member 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Abcc2  ATP-binding cassette, sub-family C (CFTR/MRP), member 2       Name updated 70584 APPROVED
2001-12-10 Abcc2  ATP-binding cassette, sub-family C (CFTR/MRP) member 2      Symbol and Name updated to reflect Human and Mouse nomenclature 69665 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease upregulated in Dubin-Johnson syndrome 69812
gene_disease upregulated in Dubin-Johnson syndrome 70559
gene_disease defects in Abcc2 are a cause of hereditary conjugated hyperbilirubinemia (EHBR) 724707
gene_expression expressed in hepatocytes 70249
gene_expression expressed in hepatocytes 70559
gene_process mediates hepatobiliary excretion of numerous organic anions 724707
gene_regulation may be reduced in response to certain types of liver damage 70249