Abcc2 (ATP binding cassette subfamily C member 2) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Abcc2 (ATP binding cassette subfamily C member 2) Rattus norvegicus
Analyze
Symbol: Abcc2
Name: ATP binding cassette subfamily C member 2
RGD ID: 2366
Description: Enables ABC-type transporter activity; bilirubin transmembrane transporter activity; and protein domain specific binding activity. Involved in several processes, including carboxylic acid transport; cellular response to cytokine stimulus; and cellular response to dexamethasone stimulus. Located in brush border membrane and intracellular canaliculus. Used to study Dubin-Johnson syndrome; bilirubin metabolic disorder; cholestasis; end stage renal disease; and visual epilepsy. Biomarker of bilirubin metabolic disorder; cholestasis; liver disease (multiple); status epilepticus; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in bilirubin metabolic disorder (multiple); carcinoma (multiple); leukemia (multiple); and liver disease (multiple). Orthologous to human ABCC2 (ATP binding cassette subfamily C member 2); PARTICIPATES IN docetaxel pharmacodynamics pathway; doxorubicin pharmacokinetics pathway; irinotecan pharmacodynamics pathway; INTERACTS WITH (+)-pilocarpine; (-)-epigallocatechin 3-gallate; (S)-colchicine.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: ATP-binding cassette sub-family C member 2; ATP-binding cassette, sub-family C (CFTR/MRP) member 2; ATP-binding cassette, sub-family C (CFTR/MRP), member 2; ATP-binding cassette, subfamily C (CFTR/MRP), member 2; calicular multispecific organic anion transporter; canalicular multidrug resistance protein; canalicular multispecific organic anion transporter; canalicular multispecific organic anion transporter 1; Cmoat; cMRP; cMrp2/cMoat canalicular apical conjugate export pump; mrp; Mrp2; multidrug resistance associated protein 2; multidrug resistance-associated protein 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Abcc2TR-   Abcc2em1Sage  
Genetic Models: WUN-Abcc2TR-/HsdRrrc SD-Abcc2em1Sage
Is Marker For: Strains:   WUN-Abcc2TR-/HsdRrrc  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81252,613,875 - 252,672,459 (+)NCBIGRCr8
mRatBN7.21242,664,657 - 242,723,239 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1242,664,657 - 242,723,238 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1250,813,581 - 250,872,198 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01257,510,469 - 257,569,198 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01250,163,726 - 250,222,340 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01263,554,426 - 263,612,556 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1263,554,453 - 263,613,252 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01270,999,832 - 271,057,750 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1238,483,399 - 238,539,595 (+)NCBICelera
Cytogenetic Map1q54NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(+/-)-Aegeline  (ISO)
(-)-epigallocatechin 3-gallate  (EXP)
(1->4)-beta-D-glucan  (ISO)
(2,4,5-trichlorophenoxy)acetic acid  (ISO)
(RS)-coclaurine  (ISO)
(RS)-norcoclaurine  (ISO)
(S)-coclaurine  (ISO)
(S)-colchicine  (EXP)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dichloroethane  (ISO)
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 17-glucosiduronic acid  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2',3'-dideoxyadenosine  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
2-acetamidofluorene  (ISO)
2-tert-butylhydroquinone  (EXP,ISO)
3',4',7-trihydroxyisoflavone  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3-chloropropane-1,2-diol  (EXP)
3-methyl-3H-imidazo[4,5-f]quinolin-2-amine  (ISO)
4'-epidoxorubicin  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
4-hydroxynon-2-enal  (EXP,ISO)
5(6)-carboxy-2',7'-dichlorofluorescein  (EXP,ISO)
5-aza-2'-deoxycytidine  (ISO)
5-chloromethylfluorescein diacetate  (ISO)
5-fluorouracil  (ISO)
5-formyltetrahydrofolic acid  (EXP)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
5-methoxypsoralen  (ISO)
6-bromoindirubin-3'-oxime  (ISO)
6-carboxyfluorescein  (ISO)
6-propyl-2-thiouracil  (EXP)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
8-(4-chlorophenylthio)-cAMP  (ISO)
8-Br-cAMP  (EXP)
8-Epidiosbulbin E acetate  (ISO)
abietic acid  (EXP)
acadesine  (EXP)
acetamide  (EXP)
actinomycin D  (EXP,ISO)
aflatoxin B1  (ISO)
AICA ribonucleotide  (EXP)
aldehydo-D-glucose  (EXP)
alfacalcidol  (ISO)
all-trans-retinoic acid  (ISO)
allyl alcohol  (ISO)
alpha-amanitin  (ISO)
aluminium hydroxide  (EXP)
amiodarone  (EXP)
amphotericin B  (ISO)
ampicillin  (ISO)
angelicin  (EXP)
antimonite  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (EXP)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (ISO)
atazanavir sulfate  (ISO)
atorvastatin calcium  (EXP,ISO)
ATP  (EXP,ISO)
azathioprine  (EXP,ISO)
aztreonam  (ISO)
benzbromarone  (EXP,ISO)
benzo[a]pyrene  (ISO)
benzoylaconine  (ISO)
benzoylhypaconine  (ISO)
benzoylmesaconine  (ISO)
benzylpenicillin  (EXP,ISO)
beta-hexachlorocyclohexane  (ISO)
beta-naphthoflavone  (EXP,ISO)
bezafibrate  (ISO)
bilirubin IXalpha  (EXP)
biochanin A  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisdemethoxycurcumin  (ISO)
bisphenol A  (EXP,ISO)
Boldine  (EXP)
bortezomib  (ISO)
bosentan  (EXP,ISO)
bromfenac  (ISO)
bromosulfophthalein  (ISO)
bromuconazole  (EXP)
bucladesine  (EXP,ISO)
buspirone  (EXP)
buta-1,3-diene  (ISO)
butanal  (ISO)
butylated hydroxyanisole  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calcein  (ISO)
calcein am  (EXP,ISO)
calcitriol  (EXP,ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
cannabidiol  (ISO)
captan  (ISO)
carbamazepine  (EXP,ISO)
carbon monoxide  (EXP)
carboplatin  (ISO)
carmustine  (ISO)
carvedilol  (ISO)
cefaloridine  (EXP)
cefalotin  (ISO)
celecoxib  (ISO)
cerivastatin  (ISO)
CGP 52608  (ISO)
chenodeoxycholic acid  (EXP,ISO)
chlorambucil  (ISO)
chlordecone  (ISO)
chlorogenic acid  (ISO)
chloroquine  (ISO)
chlorpromazine  (EXP,ISO)
chlorpyrifos  (ISO)
cholic acid  (ISO)
choline  (EXP,ISO)
chrysin  (ISO)
chrysophanol  (EXP)
ciprofloxacin  (ISO)
cisplatin  (EXP,ISO)
citalopram  (ISO)
clavulanic acid  (ISO)
clobazam  (EXP)
clofibrate  (EXP,ISO)
clofibric acid  (EXP)
clotrimazole  (ISO)
colforsin daropate hydrochloride  (ISO)
coniferyl aldehyde  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
curcumin  (ISO)
cyazofamid  (ISO)
cyclosporin A  (EXP,ISO)
cyproconazole  (EXP,ISO)
D-glucose  (EXP)
dapsone  (EXP)
daunorubicin  (ISO)
DDE  (ISO)
DDT  (ISO)
demethoxycurcumin  (ISO)
deoxycholic acid  (ISO)
desloratadine  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
Diallyl sulfide  (EXP)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
diclofenac  (EXP,ISO)
dicrotophos  (ISO)
dieldrin  (ISO)
diethyl maleate  (ISO)
diethyl phthalate  (ISO)
Dimethyl phthalate  (ISO)
dimethylarsinic acid  (EXP)
Diosbulbin B  (ISO)
dioscin  (EXP)
diosgenin  (EXP)
dioxygen  (ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (EXP,ISO)
diquat  (ISO)
disodium selenite  (ISO)
doramapimod  (ISO)
dorsomorphin  (EXP,ISO)
dothiepin  (ISO)
doxorubicin  (EXP,ISO)
DPDPE  (EXP)
E3040  (ISO)
elemental selenium  (EXP,ISO)
emodin  (EXP,ISO)
endosulfan  (EXP,ISO)
enilconazole  (ISO)
epoxiconazole  (EXP)
Erucin  (ISO)
estrone 3-sulfate  (EXP,ISO)
etacrynic acid  (ISO)
ethambutol  (EXP)
ethoxyquin  (ISO)
etoposide  (ISO)
fenofibrate  (EXP)
Fexofenadine hydrochloride  (ISO)
Finrozole  (ISO)
fipronil  (EXP,ISO)
Fluo-3  (EXP)
fluoxetine  (ISO)
flutamide  (EXP)
fluvastatin  (EXP,ISO)
formononetin  (EXP,ISO)
fosinopril  (ISO)
FR900359  (ISO)
fructose  (EXP)
fulvestrant  (EXP,ISO)
furan  (EXP)
furosemide  (EXP,ISO)
fusidic acid  (EXP)
geneticin  (ISO)
genistein  (ISO)
gentamycin  (EXP)
geraniol  (EXP)
Ginkgolide A  (ISO)
ginkgolide B  (ISO)
ginsenoside Rb2  (EXP)
ginsenoside Re  (EXP,ISO)
ginsenoside Rg1  (EXP,ISO)
ginsenoside Rg2  (EXP)
glafenine  (EXP)
glucose  (EXP)
glutathione  (EXP,ISO)
glutathione disulfide  (EXP)
glyburide  (EXP,ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
glycyrrhetinate  (EXP)
glycyrrhetinic acid  (EXP)
glyphosate  (ISO)
Goe 6976  (EXP,ISO)
gold atom  (ISO)
gold(0)  (ISO)
guggulsterone  (ISO)
GW 4064  (EXP,ISO)
hepoxilin A3  (ISO)
heptachlor  (ISO)
Heptachlor epoxide  (ISO)
hexadecanoic acid  (ISO)
hydrogen peroxide  (ISO)
Hypaconitine  (ISO)
icariside II  (ISO)
imipenem hydrate  (ISO)
indole-3-methanol  (EXP)
indometacin  (EXP,ISO)
inulin  (ISO)
irinotecan  (ISO)
iron(III) nitrilotriacetate  (ISO)
isoniazide  (EXP)
ivermectin  (ISO)
JTE-013  (EXP)
ketoconazole  (EXP,ISO)
kojic acid  (EXP)
KT 5720  (EXP,ISO)
L-ascorbic acid  (EXP,ISO)
L-cysteine  (EXP,ISO)
L-methionine  (EXP,ISO)
lead diacetate  (ISO)
leukotriene C4  (EXP,ISO)
levetiracetam  (EXP)
lipopolysaccharide  (EXP,ISO)
liquiritin  (ISO)
lithocholic acid  (EXP,ISO)
loperamide  (ISO)
lopinavir  (ISO)
loratadine  (ISO)
lovastatin  (EXP,ISO)
luteolin  (ISO)
LY294002  (ISO)
macitentan  (ISO)
manganese(II) chloride  (EXP)
Maprotiline  (EXP)
Meclizine  (ISO)
mercury atom  (EXP,ISO)
mercury dichloride  (EXP,ISO)
mercury(0)  (EXP,ISO)
Mesaconitine  (ISO)
metformin  (ISO)
methapyrilene  (EXP)
methidathion  (ISO)
methotrexate  (EXP,ISO)
methoxsalen  (ISO)
methylarsonic acid  (EXP,ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (EXP,ISO)
metiram  (ISO)
metronidazole  (ISO)
microcystin LF  (ISO)
microcystin RR  (ISO)
microcystin-LR  (ISO)
Midecamycin  (EXP,ISO)
mifepristone  (ISO)
MK 571  (EXP,ISO)
mono(2-ethylhexyl) phthalate  (ISO)
mono(glucosyluronic acid)bilirubin  (EXP,ISO)
monosodium L-glutamate  (ISO)
montelukast  (ISO)
Muraglitazar  (EXP)
myricetin  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP,ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-Acetyl-S-(1,2-dichlorovinyl)-cysteine  (ISO)
N-hydroxy-PhIP  (ISO)
N-nitrosodiethylamine  (EXP)
N-Vinyl-2-pyrrolidone  (EXP)
nelfinavir  (ISO)
neomycin  (ISO)
nifedipine  (EXP)
nimesulide  (EXP)
nitric oxide  (EXP,ISO)
nitrofen  (EXP)
nitrogen dioxide  (ISO)
nocodazole  (ISO)
norgestimate  (ISO)
notoginsenoside R1  (EXP,ISO)
Nutlin-3  (ISO)
obeticholic acid  (EXP,ISO)
ochratoxin A  (EXP,ISO)
oleanolic acid  (ISO)
olmesartan  (ISO)
oltipraz  (EXP,ISO)
omeprazole  (ISO)
organoselenium compound  (ISO)
orphenadrine  (EXP)
ortho-Aminoazotoluene  (ISO)
oxaliplatin  (ISO)
p-menthan-3-ol  (ISO)
paclitaxel  (ISO)
pantoprazole  (ISO)
paracetamol  (EXP,ISO)
parathion  (ISO)
paroxetine  (ISO)
PCB138  (ISO)
pentachlorophenol  (ISO)
perfluorobutyric acid  (ISO)
perfluorodecanoic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
perhexiline  (EXP)
phalloidin  (EXP)
phenethyl isothiocyanate  (ISO)
phenobarbital  (EXP,ISO)
phenol red  (EXP)
phenytoin  (EXP,ISO)
PhIP  (EXP,ISO)
phorbol 13-acetate 12-myristate  (EXP)
physcion  (EXP)
piperonyl butoxide  (ISO)
pirinixic acid  (EXP,ISO)
pitavastatin  (EXP,ISO)
pitavastatin(1-)  (EXP,ISO)
platinum  (ISO)
platinum(0)  (ISO)
pravastatin  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
probenecid  (EXP,ISO)
prochloraz  (EXP)
procymidone  (ISO)
progesterone  (ISO)
propane-1,2-diol  (ISO)
protein kinase inhibitor  (EXP)
prothioconazole  (ISO)
Prothioconazole-desthio  (ISO)
Prulifloxacin  (EXP)
psoralen  (EXP)
pyrazinecarboxamide  (EXP)
pyrrolidines  (EXP)
quercetin  (EXP,ISO)
reactive oxygen species  (EXP)
resveratrol  (EXP,ISO)
rifampicin  (EXP,ISO)
robinetin  (ISO)
rosuvastatin calcium  (EXP,ISO)
rotenone  (ISO)
rubitecan  (ISO)
S-(2,4-dinitrophenyl)glutathione  (EXP,ISO)
S-nitrosoglutathione  (EXP)
saquinavir  (ISO)
selenium atom  (EXP,ISO)
senecionine  (ISO)
sevoflurane  (EXP)
simvastatin  (EXP,ISO)
sincalide  (ISO)
sirolimus  (EXP)
sodium arsenate  (EXP,ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
sodium dichromate  (EXP,ISO)
sodium dodecyl sulfate  (ISO)
sodium hydrogencarbonate  (EXP)
sodium selenide  (ISO)
sorafenib  (ISO)
soybean oil  (EXP)
spironolactone  (EXP)
stilbene oxide  (EXP)
streptozocin  (EXP,ISO)
succimer  (EXP,ISO)
sulfasalazine  (EXP)
sulfinpyrazone  (ISO)
sulforaphane  (EXP,ISO)
sunitinib  (EXP)
Sunset Yellow FCF  (ISO)
tamoxifen  (EXP,ISO)
Tanshinone I  (ISO)
tartrazine  (ISO)
taurine  (EXP)
tauro-beta-muricholic acid  (EXP)
taurochenodeoxycholic acid  (EXP)
taurocholic acid  (EXP,ISO)
taurolithocholic acid  (EXP)
tauroursodeoxycholic acid  (EXP,ISO)
tectorigenin  (ISO)
Temocaprilat  (EXP)
temozolomide  (ISO)
tert-butyl hydroperoxide  (EXP,ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP)
texas red  (EXP)
Theaflavin 3,3'-digallate  (ISO)
thiacloprid  (ISO)
thioacetamide  (EXP)
thiophanate-methyl  (ISO)
thyroxine  (EXP)
Thyroxine glucuronide  (EXP)
tiagabine  (EXP)
tianeptine  (EXP)
ticlopidine  (EXP,ISO)
titanium dioxide  (ISO)
tolvaptan  (ISO)
topiramate  (EXP)
topotecan  (ISO)
trans-piceid  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
trimethylarsine oxide  (EXP)
triphenyl phosphate  (EXP,ISO)
Triptolide  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
tyrphostin AG 1478  (EXP)
uranium atom  (EXP)
urethane  (ISO)
ursodeoxycholic acid  (EXP,ISO)
vadimezan  (ISO)
valdecoxib  (EXP)
valproic acid  (EXP,ISO)
vancomycin  (EXP,ISO)
verapamil  (ISO)
vincaleukoblastine  (EXP,ISO)
vincristine  (ISO)
vitamin E  (EXP)
wortmannin  (EXP)
Y-27632  (ISO)
Yangonin  (ISO)
yohimbine  (ISO)
zearalenone  (ISO)
ziram  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
antibiotic metabolic process  (IMP)
benzylpenicillin metabolic process  (IMP)
bile acid and bile salt transport  (IEA,ISO,ISS)
bilirubin transport  (IEA,IMP,ISO)
canalicular bile acid transport  (IMP)
cellular response to dexamethasone stimulus  (IEP)
cellular response to interleukin-1  (IEP)
cellular response to interleukin-6  (IEP)
cellular response to lipopolysaccharide  (IEP)
cellular response to tumor necrosis factor  (IEP)
cellular response to xenobiotic stimulus  (IEP)
detoxification of mercury ion  (IMP)
female pregnancy  (IEP)
intracellular chloride ion homeostasis  (IDA)
leukotriene transport  (IEA,IMP,ISO)
mercury ion transport  (IMP)
negative regulation of gene expression  (IMP)
organic anion transport  (IMP,TAS)
prostaglandin transport  (IMP)
response to antineoplastic agent  (IEP)
response to arsenic-containing substance  (IEP)
response to estradiol  (IEP)
response to estrogen  (IDA,IEP)
response to glucagon  (IEP)
response to lipopolysaccharide  (IEP)
response to organic cyclic compound  (IEP)
response to oxidative stress  (IEP)
response to steroid hormone  (IEP)
response to xenobiotic stimulus  (IDA)
thyroid hormone transport  (IMP)
transepithelial transport  (IGI,IMP)
transmembrane transport  (IBA,IEA)
xenobiotic catabolic process  (IMP)
xenobiotic detoxification by transmembrane export across the plasma membrane  (IMP)
xenobiotic export from cell  (IEA,ISO)
xenobiotic transmembrane transport  (IEA,IMP,ISO)
xenobiotic transport across blood-brain barrier  (IGI,IMP)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Involvement of multidrug resistance-associated protein 2 (ABCC2/Mrp2) in biliary excretion of micafungin in rats. Abe F, etal., Life Sci. 2008 Aug 15;83(7-8):229-35. doi: 10.1016/j.lfs.2008.06.013. Epub 2008 Jul 1.
2. Involvement of Mrp2 (Abcc2) in biliary excretion of moxifloxacin and its metabolites in the isolated perfused rat liver. Ahmed S, etal., J Pharm Pharmacol. 2008 Jan;60(1):55-62. doi: 10.1211/jpp.60.1.0007.
3. Glucagon-like peptide 2 prevents down-regulation of intestinal multidrug resistance-associated protein 2 and P-glycoprotein in endotoxemic rats. Arana MR, etal., Toxicology. 2017 Sep 1;390:22-31. doi: 10.1016/j.tox.2017.08.007. Epub 2017 Aug 23.
4. Regulation of expression and activity of rat intestinal multidrug resistance-associated protein 2 by cholestatic estrogens. Arias A, etal., Drug Metab Dispos. 2009 Jun;37(6):1277-85. doi: 10.1124/dmd.108.025643. Epub 2009 Mar 19.
5. Clinical impact of ABCC1 and ABCC2 genotypes and haplotypes in mediating imatinib resistance among chronic myeloid leukaemia patients. Au A, etal., J Clin Pharm Ther. 2014 Dec;39(6):685-90. doi: 10.1111/jcpt.12197. Epub 2014 Jul 24.
6. Adenosine triphosphate-binding cassette subfamily C member 2 is the major transporter of the hepatobiliary imaging agent (99m)Tc-mebrofenin. Bhargava KK, etal., J Nucl Med. 2009 Jul;50(7):1140-6. doi: 10.2967/jnumed.109.062448. Epub 2009 Jun 12.
7. Heat stress enhances recovery of hepatocyte bile acid and organic anion transporters in endotoxemic rats by multiple mechanisms. Bolder U, etal., Cell Stress Chaperones. 2006 Spring;11(1):89-100.
8. Quantification of drug transport function across the multiple resistance-associated protein 2 (Mrp2) in rat livers. Bonnaventure P and Pastor CM, Int J Mol Sci. 2014 Dec 24;16(1):135-47. doi: 10.3390/ijms16010135.
9. Placental and fetal disposition of mercuric ions in rats exposed to methylmercury: role of Mrp2. Bridges CC, etal., Reprod Toxicol. 2012 Dec;34(4):628-34. doi: 10.1016/j.reprotox.2012.10.001. Epub 2012 Oct 8.
10. MRP2 and the handling of mercuric ions in rats exposed acutely to inorganic and organic species of mercury. Bridges CC, etal., Toxicol Appl Pharmacol. 2011 Feb 15;251(1):50-8. doi: 10.1016/j.taap.2010.11.015. Epub 2010 Dec 4.
11. cDNA cloning of the hepatocyte canalicular isoform of the multidrug resistance protein, cMrp, reveals a novel conjugate export pump deficient in hyperbilirubinemic mutant rats. Buchler M, etal., J Biol Chem 1996 Jun 21;271(25):15091-8.
12. ATP8B1 deficiency disrupts the bile canalicular membrane bilayer structure in hepatocytes, but FXR expression and activity are maintained. Cai SY, etal., Gastroenterology. 2009 Mar;136(3):1060-9. doi: 10.1053/j.gastro.2008.10.025. Epub 2008 Nov 1.
13. Drug-metabolizing enzyme and transporter expression in a mouse model of diabetes and obesity. Cheng Q, etal., Mol Pharm. 2008 Jan-Feb;5(1):77-91. Epub 2008 Jan 12.
14. MRP2 haplotypes confer differential susceptibility to toxic liver injury. Choi JH, etal., Pharmacogenet Genomics. 2007 Jun;17(6):403-15. doi: 10.1097/01.fpc.0000236337.41799.b3.
15. Involvement of Mrp2/MRP2 in the species different excretion route of benzylpenicillin between rat and human. Choi MK, etal., Xenobiotica. 2009 Feb;39(2):171-81. doi: 10.1080/00498250802642256.
16. Estradiol-17beta-D-glucuronide induces endocytic internalization of Bsep in rats. Crocenzi FA, etal., Am J Physiol Gastrointest Liver Physiol. 2003 Aug;285(2):G449-59. Epub 2003 Apr 17.
17. Drug resistance and ATP-dependent conjugate transport mediated by the apical multidrug resistance protein, MRP2, permanently expressed in human and canine cells. Cui Y, etal., Mol Pharmacol. 1999 May;55(5):929-37.
18. Genetic susceptibility to diclofenac-induced hepatotoxicity: contribution of UGT2B7, CYP2C8, and ABCC2 genotypes. Daly AK, etal., Gastroenterology. 2007 Jan;132(1):272-81. doi: 10.1053/j.gastro.2006.11.023. Epub 2006 Nov 17.
19. Multidrug resistance associated protein 2 mediates transport of prostaglandin E2. de Waart DR, etal., Liver Int. 2006 Apr;26(3):362-8.
20. Regulation of MRP2/ABCC2 and BSEP/ABCB11 expression in sandwich cultured human and rat hepatocytes exposed to inflammatory cytokines TNF-{alpha}, IL-6, and IL-1{beta}. Diao L, etal., J Biol Chem. 2010 Oct 8;285(41):31185-92. doi: 10.1074/jbc.M110.107805. Epub 2010 Aug 11.
21. Consequences of bile duct obstruction on intestinal expression and function of multidrug resistance-associated protein 2. Dietrich CG, etal., Gastroenterology. 2004 Apr;126(4):1044-53.
22. [Effects of MRP2-GSH cotransport system on hepatic arsenic metabolism in rats] Gao Y, etal., Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2006 May;24(5):278-80.
23. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
24. Characterization of organic anion transporter regulation, glutathione metabolism and bile formation in the obese Zucker rat. Geier A, etal., J Hepatol. 2005 Dec;43(6):1021-30. Epub 2005 Jul 1.
25. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
26. Association of ABCC2 polymorphisms with platinum-based chemotherapy response and severe toxicity in non-small cell lung cancer patients. Han B, etal., Lung Cancer. 2011 May;72(2):238-43. doi: 10.1016/j.lungcan.2010.09.001. Epub 2010 Oct 12.
27. Associations of ABCB1, ABCC2, and ABCG2 polymorphisms with irinotecan-pharmacokinetics and clinical outcome in patients with advanced non-small cell lung cancer. Han JY, etal., Cancer. 2007 Jul 1;110(1):138-47.
28. The pharmacokinetics of morphine and its glucuronide conjugate in a rat model of streptozotocin-induced diabetes and the expression of MRP2, MRP3 and UGT2B1 in the liver. Hasegawa Y, etal., J Pharm Pharmacol. 2010 Mar;62(3):310-4. doi: 10.1211/jpp.62.03.0004.
29. Treatment of hyperbilirubinemia in Eisai hyperbilirubinemic rat by transfecting human MRP2/ABCC2 gene. Hirouchi M, etal., Pharm Res. 2005 Apr;22(4):661-6. Epub 2005 Apr 7.
30. Association of the c.3972C>T variant of the multidrug resistance-associated protein 2 Gene (MRP2/ABCC2) with susceptibility to bile duct cancer. Hoblinger A, etal., Digestion. 2009;80(1):36-9. Epub 2009 May 19.
31. Upregulation of brain expression of P-glycoprotein in MRP2-deficient TR(-) rats resembles seizure-induced up-regulation of this drug efflux transporter in normal rats. Hoffmann K and Löscher W, Epilepsia. 2007 Apr;48(4):631-45. doi: 10.1111/j.1528-1167.2006.00939.x.
32. Expression of the multidrug transporter MRP2 in the blood-brain barrier after pilocarpine-induced seizures in rats. Hoffmann K, etal., Epilepsy Res. 2006 Apr;69(1):1-14. Epub 2006 Feb 28.
33. Single amino acid substitution of rat MRP2 results in acquired transport activity for taurocholate. Ito K, etal., Am J Physiol Gastrointest Liver Physiol 2001 Oct;281(4):G1034-43.
34. The role of protein synthesis and degradation in the post-transcriptional regulation of rat multidrug resistance-associated protein 2 (Mrp2, Abcc2). Jones BR, etal., Mol Pharmacol. 2005 Sep;68(3):701-10. Epub 2005 May 25.
35. Transport of monoglucuronosyl and bisglucuronosyl bilirubin by recombinant human and rat multidrug resistance protein 2. Kamisako T, etal., Hepatology. 1999 Aug;30(2):485-90. doi: 10.1002/hep.510300220.
36. Prospective evaluation of the drug-metabolizing enzyme polymorphisms and toxicity profile of docetaxel in Korean patients with operable lymph node-positive breast cancer receiving adjuvant chemotherapy. Kim KP, etal., Cancer Chemother Pharmacol. 2012 May;69(5):1221-7. doi: 10.1007/s00280-011-1816-4. Epub 2012 Jan 20.
37. Differences in the pharmacokinetics of peroxisome proliferator-activated receptor agonists in genetically obese Zucker and sprague-dawley rats: implications of decreased glucuronidation in obese Zucker rats. Kim MS, etal., Drug Metab Dispos. 2004 Sep;32(9):909-14.
38. Polymorphisms in drug transporter genes (ABCB1, SLCO1B1 and ABCC2) and hepatitis induced by antituberculosis drugs. Kim SH, etal., Tuberculosis (Edinb). 2012 Jan;92(1):100-4. doi: 10.1016/j.tube.2011.09.007. Epub 2011 Dec 16.
39. Association of genetic polymorphisms in SLCO1B3 and ABCC2 with docetaxel-induced leukopenia. Kiyotani K, etal., Cancer Sci. 2008 May;99(5):967-72. doi: 10.1111/j.1349-7006.2008.00765.x. Epub 2008 Feb 19.
40. Increased plasma post-heparin diamine oxidase activity and plant sterol levels in streptozotocin diabetic rat. Kojima H, etal., Biochem Biophys Res Commun. 1992 Jul 15;186(1):398-404.
41. Key determinants of the circulatory exposure of organic anions: differences in hepatic uptake between multidrug resistance-associated protein 2 (Mrp2)-deficient rats and wild-type rats. Kosaka K, etal., Xenobiotica. 2015;45(6):556-62. doi: 10.3109/00498254.2014.997820. Epub 2014 Dec 24.
42. Hepatobiliary disposition of thyroid hormone in Mrp2-deficient TR- rats: reduced biliary excretion of thyroxine glucuronide does not prevent xenobiotic-induced hypothyroidism. Lecureux L, etal., Toxicol Sci. 2009 Apr;108(2):482-91. Epub 2009 Feb 11.
43. The relationship of polymorphisms in ABCC2 and SLCO1B3 with docetaxel pharmacokinetics and neutropenia: CALGB 60805 (Alliance). Lewis LD, etal., Pharmacogenet Genomics. 2013 Jan;23(1):29-33. doi: 10.1097/FPC.0b013e32835b16d8.
44. NHERF-1 binds to Mrp2 and regulates hepatic Mrp2 expression and function. Li M, etal., J Biol Chem. 2010 Jun 18;285(25):19299-307. doi: 10.1074/jbc.M109.096081. Epub 2010 Apr 19.
45. Mrp2 modulates the activity of chloride channels in isolated hepatocytes. Li X and Weinman SA, Hepatology. 2002 Jul;36(1):65-71.
46. Role of AMP-activated protein kinase α1 in 17α-ethinylestradiol-induced cholestasis in rats. Li X, etal., Arch Toxicol. 2017 Jan;91(1):481-494. doi: 10.1007/s00204-016-1697-8. Epub 2016 Apr 18.
47. Association of ABCC2 -24C>T polymorphism with high-dose methotrexate plasma concentrations and toxicities in childhood acute lymphoblastic leukemia. Liu Y, etal., PLoS One. 2014 Jan 3;9(1):e82681. doi: 10.1371/journal.pone.0082681. eCollection 2014.
48. Functional induction of P-glycoprotein in the blood-brain barrier of streptozotocin-induced diabetic rats: evidence for the involvement of nuclear factor-kappaB, a nitrosative stress-sensitive transcription factor, in the regulation. Maeng HJ, etal., Drug Metab Dispos. 2007 Nov;35(11):1996-2005. Epub 2007 Jul 30.
49. 4-Hydroxyacetophenone-induced choleresis in rats is mediated by the Mrp2-dependent biliary secretion of its glucuronide conjugate. Mahagita C, etal., Pharm Res. 2006 Nov;23(11):2603-10. Epub 2006 Sep 29.
50. Metabolism and disposition of acetaminophen: recent advances in relation to hepatotoxicity and diagnosis. McGill MR and Jaeschke H, Pharm Res. 2013 Sep;30(9):2174-87. doi: 10.1007/s11095-013-1007-6. Epub 2013 Mar 6.
51. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
52. Zonation of multidrug resistance-associated protein 2 in rat liver after induction with dexamethasone. Micuda S, etal., J Gastroenterol Hepatol. 2008 Jul;23(7 Pt 2):e225-30. Epub 2007 Aug 6.
53. Correlation between apical localization of Abcc2/Mrp2 and phosphorylation status of ezrin in rat intestine. Nakano T, etal., Drug Metab Dispos. 2009 Jul;37(7):1521-7. Epub 2009 Apr 1.
54. Down-regulation of intestinal drug transporters in chronic renal failure in rats. Naud J, etal., J Pharmacol Exp Ther. 2007 Mar;320(3):978-85. Epub 2006 Nov 29.
55. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
56. Expression of multidrug resistance-associated protein 2 is involved in chemotherapy resistance in human pancreatic cancer. Noma B, etal., Int J Oncol. 2008 Dec;33(6):1187-94.
57. Increased apical insertion of the multidrug resistance protein 2 (MRP2/ABCC2) in renal proximal tubules following gentamicin exposure. Notenboom S, etal., J Pharmacol Exp Ther. 2006 Sep;318(3):1194-202. Epub 2006 Jun 6.
58. Renal and hepatic transporter expression in type 2 diabetic rats. Nowicki MT, etal., Drug Metab Lett. 2008 Jan;2(1):11-7.
59. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
60. Congenital jaundice in rats with a mutation in a multidrug resistance-associated protein gene. Paulusma CC, etal., Science 1996 Feb 23;271(5252):1126-8.
61. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
62. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
63. Magnetic resonance imaging with hepatospecific contrast agents in cirrhotic rat livers. Planchamp C, etal., Invest Radiol. 2005 Apr;40(4):187-94.
64. Multidrug resistance protein MRP2 contributes to blood-brain barrier function and restricts antiepileptic drug activity. Potschka H, etal., J Pharmacol Exp Ther 2003 Jul;306(1):124-31.
65. GOA pipeline RGD automated data pipeline
66. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
67. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
68. Oxidative stress and Mrp2 internalization. Sekine S, etal., Free Radic Biol Med. 2006 Jun 15;40(12):2166-74. Epub 2006 Mar 13.
69. Effect of 5-fluorouracil treatment on SN-38 absorption from intestine in rats. Shibayama Y, etal., Biol Pharm Bull. 2011;