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Gene: Abcc2 (ATP binding cassette subfamily C member 2) Rattus norvegicus
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Symbol: Abcc2
Name: ATP binding cassette subfamily C member 2
Description: Exhibits protein domain specific binding activity. Involved in several processes, including cellular response to cytokine stimulus; cellular response to lipid; and monocarboxylic acid transport. Localizes to the apical plasma membrane and brush border membrane. Used to study Dubin-Johnson syndrome; bilirubin metabolic disorder; cholestasis; end stage renal failure; and visual epilepsy. Biomarker of bilirubin metabolic disorder; cholestasis; fatty liver disease; status epilepticus; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in bilirubin metabolic disorder (multiple); carcinoma (multiple); and leukemia (multiple). Orthologous to human ABCC2 (ATP binding cassette subfamily C member 2); PARTICIPATES IN docetaxel pharmacodynamics pathway; doxorubicin pharmacokinetics pathway; irinotecan pharmacodynamics pathway; INTERACTS WITH (+)-pilocarpine; (-)-epigallocatechin 3-gallate; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ATP-binding cassette sub-family C member 2; ATP-binding cassette, sub-family C (CFTR/MRP) member 2; ATP-binding cassette, sub-family C (CFTR/MRP), member 2; ATP-binding cassette, subfamily C (CFTR/MRP), member 2; calicular multispecific organic anion transporter; canalicular multidrug resistance protein; canalicular multispecific organic anion transporter; canalicular multispecific organic anion transporter 1; Cmoat; cMRP; cMrp2/cMoat canalicular apical conjugate export pump; mrp; Mrp2; multidrug resistance associated protein 2; multidrug resistance-associated protein 2
Orthologs:
Homo sapiens (human) : ABCC2 (ATP binding cassette subfamily C member 2)  HGNC  Alliance
Mus musculus (house mouse) : Abcc2 (ATP-binding cassette, sub-family C (CFTR/MRP), member 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Abcc2 (ATP binding cassette subfamily C member 2)
Pan paniscus (bonobo/pygmy chimpanzee) : ABCC2 (ATP binding cassette subfamily C member 2)
Canis lupus familiaris (dog) : ABCC2 (ATP binding cassette subfamily C member 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Abcc2 (ATP binding cassette subfamily C member 2)
Sus scrofa (pig) : ABCC2 (ATP binding cassette subfamily C member 2)
more info ...
Allele / Splice: Abcc2TR-   Abcc2em1Sage  
Genetic Models: SD-Abcc2em1Sage WUN-Abcc2TR-/HsdRrrc
Is Marker For: Strains:   WUN-Abcc2TR-/HsdRrrc  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01263,554,426 - 263,612,556 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01270,999,832 - 271,057,750 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1238,483,399 - 238,539,595 (+)NCBICelera
Cytogenetic Map1q54NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
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Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Related Rat Strains
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miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
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Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Abcc2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2366
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-07-09
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.