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Gene: Cyp17a1 (cytochrome P450, family 17, subfamily a, polypeptide 1) Rattus norvegicus
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Symbol: Cyp17a1
Name: cytochrome P450, family 17, subfamily a, polypeptide 1
Description: Exhibits steroid 17-alpha-monooxygenase activity. Involved in several processes, including animal organ development; dibenzo-p-dioxin metabolic process; and phthalate metabolic process. Localizes to the cell projection; endoplasmic reticulum; and neuronal cell body. Biomarker of sciatic neuropathy. Human ortholog(s) of this gene implicated in several diseases, including cholelithiasis; congenital adrenal hyperplasia; gallbladder cancer; osteoporosis; and prostate cancer. Orthologous to human CYP17A1 (cytochrome P450 family 17 subfamily A member 1); PARTICIPATES IN 11-beta-hydroxylase deficiency pathway; 17-alpha-hydroxylase deficiency pathway; 21-alpha-hydroxylase deficiency pathway; INTERACTS WITH (+)-schisandrin B; (S)-nicotine; 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: 17-alpha-hydroxyprogesterone aldolase; Cyp17; CYPXVII; cytochrome P450 17A1; Cytochrome P450 subfamily XVII; cytochrome P450, subfamily 17; Cytochrome P450, subfamily XVII; cytochrome P450-C17; cytochrome P450c17; P450-C17; P45017alpha; P450c17; steroid 17-alpha-hydroxylase/17,20 lyase; steroid 17-alpha-monooxygenase
Orthologs:
Homo sapiens (human) : CYP17A1 (cytochrome P450 family 17 subfamily A member 1)  HGNC  Alliance
Mus musculus (house mouse) : Cyp17a1 (cytochrome P450, family 17, subfamily a, polypeptide 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : LOC102011010 (steroid 17-alpha-hydroxylase/17,20 lyase)
Pan paniscus (bonobo/pygmy chimpanzee) : LOC100989182 (steroid 17-alpha-hydroxylase/17,20 lyase)
Canis lupus familiaris (dog) : CYP17A1 (cytochrome P450 family 17 subfamily A member 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : LOC101970767 (steroid 17-alpha-hydroxylase/17,20 lyase)
Sus scrofa (pig) : CYP17A1 (cytochrome P450 17A1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01266,422,127 - 266,429,947 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1266,422,132 - 266,428,239 (-)Ensembl
Rnor_5.01273,852,163 - 273,859,866 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41251,965,458 - 251,971,449 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11252,228,608 - 252,234,604 (-)NCBI
Celera1241,321,307 - 241,327,254 (-)NCBICelera
Cytogenetic Map1q54NCBI
RH 3.4 Map11626.0RGD
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Cyp17a1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2456
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-11-27
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.