CYP17A1 (cytochrome P450 family 17 subfamily A member 1) - Rat Genome Database

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Gene: CYP17A1 (cytochrome P450 family 17 subfamily A member 1) Canis lupus familiaris
Analyze
Symbol: CYP17A1
Name: cytochrome P450 family 17 subfamily A member 1
RGD ID: 12103887
Description: ENCODES a protein that exhibits steroid 17-alpha-monooxygenase activity (ortholog); INVOLVED IN adrenal gland development (ortholog); biphenyl metabolic process (ortholog); cellular response to antibiotic (ortholog); PARTICIPATES IN 11-beta-hydroxylase deficiency pathway; 17-alpha-hydroxylase deficiency pathway; 21-alpha-hydroxylase deficiency pathway; ASSOCIATED WITH 17,20-Lyase Deficiency, Isolated (ortholog); amenorrhea (ortholog); breast cancer (ortholog); FOUND IN cell projection (ortholog); endoplasmic reticulum (ortholog); intracellular membrane-bounded organelle (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: cytochrome P450, family 17, subfamily A, polypeptide 1; steroid 17-alpha-hydroxylase/17,20 lyase
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12815,292,959 - 15,298,896 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2815,293,106 - 15,298,852 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2815,464,817 - 15,470,751 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02815,766,953 - 15,772,955 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2815,764,529 - 15,772,909 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12815,310,874 - 15,316,795 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02815,350,683 - 15,356,605 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02815,483,290 - 15,489,212 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:32657440  


Genomics

Comparative Map Data
CYP17A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12815,292,959 - 15,298,896 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2815,293,106 - 15,298,852 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2815,464,817 - 15,470,751 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02815,766,953 - 15,772,955 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2815,764,529 - 15,772,909 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12815,310,874 - 15,316,795 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02815,350,683 - 15,356,605 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02815,483,290 - 15,489,212 (-)NCBIUU_Cfam_GSD_1.0
CYP17A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810102,830,531 - 102,837,413 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl10102,830,531 - 102,837,472 (-)EnsemblGRCh38hg38GRCh38
GRCh3710104,590,288 - 104,597,170 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3610104,580,278 - 104,587,280 (-)NCBINCBI36Build 36hg18NCBI36
Build 3410104,580,283 - 104,587,168NCBI
Celera1098,331,010 - 98,337,873 (-)NCBICelera
Cytogenetic Map10q24.32NCBI
HuRef1098,225,099 - 98,232,065 (-)NCBIHuRef
CHM1_110104,873,550 - 104,880,507 (-)NCBICHM1_1
T2T-CHM13v2.010103,716,316 - 103,723,198 (-)NCBIT2T-CHM13v2.0
Cyp17a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391946,655,604 - 46,661,439 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1946,655,604 - 46,661,611 (-)EnsemblGRCm39 Ensembl
GRCm381946,667,165 - 46,673,000 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1946,667,165 - 46,673,172 (-)EnsemblGRCm38mm10GRCm38
MGSCv371946,741,655 - 46,747,490 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361946,720,491 - 46,726,285 (-)NCBIMGSCv36mm8
Celera1947,437,171 - 47,443,006 (-)NCBICelera
Cytogenetic Map19C3NCBI
cM Map1938.97NCBI
Cyp17a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21245,535,462 - 245,543,148 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1245,535,462 - 245,541,573 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1253,668,318 - 253,675,994 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01260,357,408 - 260,365,097 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01253,011,215 - 253,018,898 (-)NCBIRnor_WKY
Rnor_6.01266,422,127 - 266,429,947 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1266,422,132 - 266,428,239 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01273,852,163 - 273,859,866 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41251,965,458 - 251,971,449 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11252,228,608 - 252,234,604 (-)NCBI
Celera1241,321,307 - 241,327,254 (-)NCBICelera
RH 3.4 Map11626.0RGD
Cytogenetic Map1q54NCBI
LOC102011010
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554857,645,363 - 7,650,658 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554857,615,132 - 7,652,899 (+)NCBIChiLan1.0ChiLan1.0
CYP17A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.110102,891,280 - 102,901,963 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl10102,896,376 - 102,901,514 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01099,431,762 - 99,439,619 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
LOC101970767
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721331,494,353 - 31,499,609 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049366003,097,620 - 3,102,713 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CYP17A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14113,805,611 - 113,812,041 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114113,805,616 - 113,820,445 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214123,773,108 - 123,787,947 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CYP17A1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1995,870,098 - 95,877,345 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl995,866,908 - 95,877,180 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604856,981,761 - 56,989,146 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
LOC101726496
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248312,157,048 - 2,166,539 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248312,155,851 - 2,166,621 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High 5
Medium
Low 1 1 1 1 2 1 8 1
Below cutoff 4 5 14 4 6 4 3 5 11 9 5

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000016342   ⟹   ENSCAFP00000015117
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2815,293,106 - 15,298,852 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000063113   ⟹   ENSCAFP00000052540
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2815,293,106 - 15,298,852 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000064777   ⟹   ENSCAFP00000046946
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2815,293,294 - 15,298,852 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000070679   ⟹   ENSCAFP00000049862
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2815,293,106 - 15,298,852 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000071017   ⟹   ENSCAFP00000059904
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2815,293,106 - 15,297,789 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000080503   ⟹   ENSCAFP00000063666
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2815,293,106 - 15,298,826 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845045378   ⟹   ENSCAFP00845035592
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2815,764,529 - 15,772,909 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845045497   ⟹   ENSCAFP00845035687
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2815,767,100 - 15,772,909 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845045568   ⟹   ENSCAFP00845035743
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2815,767,100 - 15,772,909 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845045631   ⟹   ENSCAFP00845035800
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2815,767,100 - 15,772,909 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845045686   ⟹   ENSCAFP00845035850
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2815,767,100 - 15,772,883 (-)Ensembl
RefSeq Acc Id: XM_005637679   ⟹   XP_005637736
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12815,292,959 - 15,298,896 (-)NCBI
Dog10K_Boxer_Tasha2815,464,817 - 15,470,751 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038440430   ⟹   XP_038296358
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02815,766,953 - 15,772,955 (-)NCBI
RefSeq Acc Id: XM_038440431   ⟹   XP_038296359
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02815,767,288 - 15,772,883 (-)NCBI
RefSeq Acc Id: XM_038515052   ⟹   XP_038370980
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.12815,310,874 - 15,316,795 (-)NCBI
RefSeq Acc Id: XM_038515053   ⟹   XP_038370981
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.12815,311,209 - 15,316,723 (-)NCBI
RefSeq Acc Id: XM_038578657   ⟹   XP_038434585
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.02815,483,290 - 15,489,212 (-)NCBI
RefSeq Acc Id: XM_038578658   ⟹   XP_038434586
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.02815,483,625 - 15,489,140 (-)NCBI
RefSeq Acc Id: XM_038642841   ⟹   XP_038498769
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.02815,350,683 - 15,356,605 (-)NCBI
RefSeq Acc Id: XM_038642842   ⟹   XP_038498770
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.02815,351,018 - 15,356,533 (-)NCBI
RefSeq Acc Id: XM_535000   ⟹   XP_535000
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12815,293,294 - 15,298,826 (-)NCBI
Dog10K_Boxer_Tasha2815,465,152 - 15,470,679 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_535000   ⟸   XM_535000
- Peptide Label: isoform X2
- UniProtKB: A0A8C0PJZ0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005637736   ⟸   XM_005637679
- Peptide Label: isoform X1
- UniProtKB: A0A8C0TRG3 (UniProtKB/TrEMBL),   E2RKV5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000046946   ⟸   ENSCAFT00000064777
RefSeq Acc Id: ENSCAFP00000049862   ⟸   ENSCAFT00000070679
RefSeq Acc Id: ENSCAFP00000052540   ⟸   ENSCAFT00000063113
RefSeq Acc Id: ENSCAFP00000063666   ⟸   ENSCAFT00000080503
RefSeq Acc Id: ENSCAFP00000015117   ⟸   ENSCAFT00000016342
RefSeq Acc Id: ENSCAFP00000059904   ⟸   ENSCAFT00000071017
RefSeq Acc Id: XP_038370980   ⟸   XM_038515052
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038370981   ⟸   XM_038515053
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038498769   ⟸   XM_038642841
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038498770   ⟸   XM_038642842
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038296358   ⟸   XM_038440430
- Peptide Label: isoform X1
- UniProtKB: A0A8C0TRG3 (UniProtKB/TrEMBL),   E2RKV5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038296359   ⟸   XM_038440431
- Peptide Label: isoform X2
- UniProtKB: A0A8C0PJZ0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038434585   ⟸   XM_038578657
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038434586   ⟸   XM_038578658
- Peptide Label: isoform X2
RefSeq Acc Id: ENSCAFP00845035743   ⟸   ENSCAFT00845045568
RefSeq Acc Id: ENSCAFP00845035592   ⟸   ENSCAFT00845045378
RefSeq Acc Id: ENSCAFP00845035850   ⟸   ENSCAFT00845045686
RefSeq Acc Id: ENSCAFP00845035687   ⟸   ENSCAFT00845045497
RefSeq Acc Id: ENSCAFP00845035800   ⟸   ENSCAFT00845045631


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000010279 Ensembl
  ENSCAFG00030024481 UniProtKB/TrEMBL
  ENSCAFG00040023677 UniProtKB/TrEMBL
  ENSCAFG00845025701 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSCAFP00030039332.1 UniProtKB/TrEMBL
  ENSCAFP00030039347.1 UniProtKB/TrEMBL
  ENSCAFP00030039352.1 UniProtKB/TrEMBL
  ENSCAFP00030039368.1 UniProtKB/TrEMBL
  ENSCAFP00030039386.1 UniProtKB/TrEMBL
  ENSCAFP00040038606 UniProtKB/TrEMBL
  ENSCAFP00040038636 UniProtKB/TrEMBL
  ENSCAFP00040038644 UniProtKB/TrEMBL
  ENSCAFP00040038669 UniProtKB/TrEMBL
  ENSCAFP00040038691 UniProtKB/TrEMBL
  ENSCAFP00845035592.1 UniProtKB/TrEMBL
  ENSCAFP00845035687 ENTREZGENE
  ENSCAFP00845035687.1 UniProtKB/TrEMBL
  ENSCAFP00845035743 ENTREZGENE
  ENSCAFP00845035743.1 UniProtKB/TrEMBL
  ENSCAFP00845035800.1 UniProtKB/TrEMBL
  ENSCAFP00845035850.1 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00030045047.1 UniProtKB/TrEMBL
  ENSCAFT00030045064.1 UniProtKB/TrEMBL
  ENSCAFT00030045072.1 UniProtKB/TrEMBL
  ENSCAFT00030045094.1 UniProtKB/TrEMBL
  ENSCAFT00030045118.1 UniProtKB/TrEMBL
  ENSCAFT00040044222 UniProtKB/TrEMBL
  ENSCAFT00040044256 UniProtKB/TrEMBL
  ENSCAFT00040044264 UniProtKB/TrEMBL
  ENSCAFT00040044290 UniProtKB/TrEMBL
  ENSCAFT00040044319 UniProtKB/TrEMBL
  ENSCAFT00845045378.1 UniProtKB/TrEMBL
  ENSCAFT00845045497 ENTREZGENE
  ENSCAFT00845045497.1 UniProtKB/TrEMBL
  ENSCAFT00845045568 ENTREZGENE
  ENSCAFT00845045568.1 UniProtKB/TrEMBL
  ENSCAFT00845045631.1 UniProtKB/TrEMBL
  ENSCAFT00845045686.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.630.10 UniProtKB/TrEMBL
InterPro Cyt_P450 UniProtKB/TrEMBL
  Cyt_P450_CS UniProtKB/TrEMBL
  Cyt_P450_E_grp-I UniProtKB/TrEMBL
  Cyt_P450_sf UniProtKB/TrEMBL
NCBI Gene CYP17A1 ENTREZGENE
Pfam p450 UniProtKB/TrEMBL
PRINTS EP450I UniProtKB/TrEMBL
  P450 UniProtKB/TrEMBL
PROSITE CYTOCHROME_P450 UniProtKB/TrEMBL
Superfamily-SCOP SSF48264 UniProtKB/TrEMBL
UniProt A0A8C0PC31_CANLF UniProtKB/TrEMBL
  A0A8C0PI34_CANLF UniProtKB/TrEMBL
  A0A8C0PJZ0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0RSP4_CANLF UniProtKB/TrEMBL
  A0A8C0TKJ6_CANLF UniProtKB/TrEMBL
  A0A8C0TRG3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0TRN0_CANLF UniProtKB/TrEMBL
  A0A8I3PR85_CANLF UniProtKB/TrEMBL
  A0A8I3PS97_CANLF UniProtKB/TrEMBL
  A0A8I3PVV7_CANLF UniProtKB/TrEMBL
  A0A8I3PYF7_CANLF UniProtKB/TrEMBL
  A0A8I3S5L1_CANLF UniProtKB/TrEMBL
  E2RKV5 ENTREZGENE
VGNC ID VGNC:50330 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-01-09 CYP17A1  cytochrome P450 family 17 subfamily A member 1    cytochrome P450, family 17, subfamily A, polypeptide 1  Symbol and/or name change 5135510 APPROVED