GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Cyp17a1 | increases expression | EXP | | 6480464 | CTD | perfluorooctane sulfonic acid results in increased expression of CYP17A1 mRNA | PMID:16221955 PMID:18692542 PMID:19162173 | Cyp17a1 | decreases expression | ISO | CYP17A1 (Homo sapiens) | 6480464 | CTD | perfluorooctane sulfonic acid results in decreased expression of CYP17A1 mRNA | PMID:23074026 | Cyp17a1 | multiple interactions | ISO | CYP17A1 (Homo sapiens) | 6480464 | CTD | [CYP17A1 gene SNP affects the susceptibility to perfluorooctane sulfonic acid] which affects the abundance of Androstenedione; [CYP17A1 gene SNP affects the susceptibility to perfluorooctane sulfonic acid] which affects the abundance of Testosterone | PMID:34536543 | Cyp17a1 | multiple interactions | ISO | Cyp17a1 (Mus musculus) | 6480464 | CTD | [perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of CYP17A1 mRNA; [perfluorooctane sulfonic acid co-treated with Inulin] results in decreased expression of CYP17A1 mRNA; [perfluorooctane sulfonic acid co-treated with Pectins] results in decreased expression of CYP17A1 mRNA | PMID:36331819 | |
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