Cyp17a1 (cytochrome P450, family 17, subfamily a, polypeptide 1) - Rat Genome Database

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Gene: Cyp17a1 (cytochrome P450, family 17, subfamily a, polypeptide 1) Mus musculus
Analyze
Symbol: Cyp17a1
Name: cytochrome P450, family 17, subfamily a, polypeptide 1
RGD ID: 737222
MGI Page MGI
Description: Enables steroid 17-alpha-monooxygenase activity. Acts upstream of or within glucocorticoid biosynthetic process. Located in axon and neuronal cell body. Is expressed in several structures, including adrenal gland; gut; nervous system; reproductive system; and retina layer. Human ortholog(s) of this gene implicated in several diseases, including cholelithiasis; congenital adrenal hyperplasia; gallbladder cancer; osteoporosis; and prostate cancer. Orthologous to human CYP17A1 (cytochrome P450 family 17 subfamily A member 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 17-alpha-hydroxyprogesterone aldolase; Cyp1; Cyp17; CYPXVII; cytochrome P450 17A1; cytochrome P450, 17; cytochrome P450, 17a1; cytochrome P450-C17; cytochrome P450c17; p450c1; p450c17; steroid 17-alpha hydroxylase; steroid 17-alpha-hydroxylase/17,20 lyase; steroid 17-alpha-monooxygenase
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391946,655,604 - 46,661,439 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1946,655,604 - 46,661,611 (-)EnsemblGRCm39 Ensembl
GRCm381946,667,165 - 46,673,000 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1946,667,165 - 46,673,172 (-)EnsemblGRCm38mm10GRCm38
MGSCv371946,741,655 - 46,747,490 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361946,720,491 - 46,726,285 (-)NCBIMGSCv36mm8
Celera1947,437,171 - 47,443,006 (-)NCBICelera
Cytogenetic Map19C3NCBI
cM Map1938.97NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(E)-thiamethoxam  (ISO)
(R)-carnitine  (ISO)
(R,R)-tramadol  (ISO)
(S)-duloxetine hydrochloride  (ISO)
(S)-nicotine  (ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP,ISO)
1,1,1-Trichloro-2-(4-hydroxyphenyl)-2-(4-methoxyphenyl)ethane  (EXP)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,2-dichloroethane  (EXP)
1,3,4-oxadiazoles  (ISO)
1,3-dinitrobenzene  (ISO)
1-methylnicotinamide  (ISO)
1-naphthylamine  (ISO)
16-Hydroxyprogesterone  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17alpha-hydroxypregnenolone  (ISO)
17alpha-hydroxyprogesterone  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (ISO)
1H-pyrazole  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,4,7,8-Pentachlorodibenzofuran  (ISO)
2,3,7,8-tetrabromodibenzodioxine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4,6-tribromophenol  (ISO)
2,4-D  (EXP)
2,4-dibromophenol  (ISO)
2,4-dinitrotoluene  (ISO)
2,6-dibromophenol  (ISO)
2-bromophenol  (ISO)
2-methoxyethanol  (ISO)
2-trans,6-trans,10-trans-geranylgeranyl diphosphate  (ISO)
2-trans,6-trans-farnesyl diphosphate  (ISO)
3',5'-cyclic AMP  (EXP,ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP,ISO)
3,3',5-triiodo-L-thyronine  (EXP)
3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluoro-1-decanol  (ISO)
3,4-dichloroaniline  (ISO)
3-chloropropane-1,2-diol  (ISO)
3alpha-hydroxy-5beta-pregnan-20-one  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile  (ISO)
4-nitro-m-cresol  (EXP)
4-nonylphenol  (EXP)
4-octylphenol  (ISO)
4-tert-Octylphenol  (EXP)
5alpha-pregnane-3,20-dione  (ISO)
8-Br-cAMP  (EXP,ISO)
abiraterone  (ISO)
acetaldehyde  (EXP)
acetamide  (ISO)
acetamiprid  (EXP)
Acetyl tributyl citrate  (ISO)
aconitine  (ISO)
aflatoxin B1  (EXP)
albuterol  (ISO)
alginic acid  (EXP)
all-trans-retinoic acid  (EXP,ISO)
allethrin  (ISO)
alpha-naphthoflavone  (ISO)
alternariol  (ISO)
aminoglutethimide  (ISO)
ammonium chloride  (ISO)
androgen antagonist  (ISO)
andrographolide  (EXP)
androst-4-ene-3,17-dione  (EXP,ISO)
androsterone  (ISO)
antalarmin  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
apigenin  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (EXP)
astressin  (ISO)
atorvastatin calcium  (ISO)
atrazine  (EXP,ISO)
benomyl  (ISO)
benzene  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (EXP)
berberine  (EXP)
beta-damascenone  (EXP)
beta-naphthoflavone  (EXP)
bexarotene  (ISO)
bifenthrin  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP,ISO)
bromobenzene  (ISO)
bucladesine  (ISO)
Butylbenzyl phthalate  (EXP,ISO)
Butylparaben  (ISO)
C60 fullerene  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
carbamazepine  (ISO)
carbon nanotube  (EXP)
cetrorelix  (ISO)
chenodeoxycholic acid  (EXP)
chlordecone  (EXP)
chlorohydrocarbon  (ISO)
chloroquine  (ISO)
chlorpyrifos  (EXP)
cholesterol  (EXP)
Chorionic gonadotropin  (ISO)
chromium(6+)  (ISO)
chrysene  (EXP)
clofibrate  (EXP,ISO)
clofibric acid  (ISO)
clotrimazole  (ISO)
colforsin daropate hydrochloride  (EXP,ISO)
corticotropin  (ISO)
cyanamide  (EXP)
cyclosporin A  (EXP,ISO)
cyhalothrin  (ISO)
cypermethrin  (EXP,ISO)
DDE  (ISO)
DDT  (EXP)
decabromodiphenyl ether  (ISO)
dehydroepiandrosterone  (EXP,ISO)
deoxynivalenol  (ISO)
desogestrel  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (EXP)
Di-n-hexyl phthalate  (ISO)
diarsenic trioxide  (EXP)
dibromoacetic acid  (ISO)
dibutyl phthalate  (EXP,ISO)
diclofenac  (EXP)
Dicyclohexyl phthalate  (ISO)
dienestrol  (ISO)
diethyl phthalate  (EXP,ISO)
diethylstilbestrol  (EXP,ISO)
diheptyl phthalate  (ISO)
diisobutyl phthalate  (EXP,ISO)
diisononyl phthalate  (EXP,ISO)
dipentyl phthalate  (ISO)
disulfiram  (EXP)
drospirenone  (ISO)
endosulfan  (EXP)
enilconazole  (EXP)
enniatin  (ISO)
enzacamene  (ISO)
epoxiconazole  (EXP)
equol  (EXP)
estrone  (ISO)
etoxazole  (EXP)
farnesyl diphosphate  (ISO)
fenarimol  (EXP)
fenvalerate  (EXP,ISO)
fluconazole  (ISO)
flufenoxuron  (EXP)
flurbiprofen  (ISO)
flutamide  (EXP,ISO)
folic acid  (EXP)
fulvestrant  (EXP,ISO)
fumonisin B1  (EXP)
galaxolide  (ISO)
gamma-hexachlorocyclohexane  (ISO)
geldanamycin  (EXP)
genistein  (EXP,ISO)
gentamycin  (ISO)
glafenine  (ISO)
herbicide  (ISO)
hexane  (ISO)
HT-2 toxin  (ISO)
hydrazine  (ISO)
hydroxyflutamide  (ISO)
imidacloprid  (EXP,ISO)
iodoacetic acid  (EXP)
isoflavones  (ISO)
isoliquiritigenin  (EXP)
ketoconazole  (ISO)
lamotrigine  (ISO)
lead diacetate  (EXP)
leflunomide  (ISO)
letrozole  (ISO)
levetiracetam  (ISO)
levonorgestrel  (ISO)
linuron  (ISO)
lipopolysaccharide  (EXP)
luteolin  (ISO)
metformin  (EXP,ISO)
methidathion  (EXP)
methotrexate  (EXP)
methoxyacetic acid  (EXP)
methoxychlor  (EXP)
methylmercury chloride  (ISO)
metyrapone  (ISO)
miconazole  (ISO)
Mitotane  (ISO)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
monobenzyl phthalate  (EXP)
Monobutylphthalate  (ISO)
monoethyl phthalate  (EXP)
Muraglitazar  (ISO)
mycotoxin  (ISO)
N-acetyl-L-cysteine  (ISO)
N-ethyl-N-nitrosourea  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (ISO)
nickel sulfate  (ISO)
nicotinamide  (ISO)
nicotine  (ISO)
Nodularin  (ISO)
oxycodone  (ISO)
ozone  (EXP)
p-tert-Amylphenol  (EXP)
paracetamol  (EXP,ISO)
paraquat  (ISO)
parathion  (EXP)
PCB138  (EXP)
pentachlorophenol  (EXP,ISO)
perflubron  (ISO)
perfluorododecanoic acid  (ISO)
perfluorononanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
perfluoroundecanoic acid  (ISO)
phenformin  (ISO)
phenobarbital  (EXP,ISO)
pioglitazone  (ISO)
piperonyl butoxide  (ISO)
pirinixic acid  (EXP,ISO)
potassium dichromate  (ISO)
pregnenolone  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
prochloraz  (ISO)
profenofos  (ISO)
progesterone  (ISO)
prostaglandin E2  (ISO)
pyruvic acid  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
SB 203580  (ISO)
sertraline  (ISO)
simvastatin  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
sphingosine  (ISO)
sphingosine 1-phosphate  (ISO)
T-2 toxin  (EXP)
tamoxifen  (EXP,ISO)
terbutylazine  (EXP)
Tesaglitazar  (ISO)
testosterone  (EXP,ISO)
testosterone enanthate  (ISO)
Testosterone propionate  (EXP)
testosterone undecanoate  (ISO)
tetrachloroethene  (EXP)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP)
tetraphene  (EXP,ISO)
thiamethoxam  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
topiramate  (ISO)
torcetrapib  (ISO)
tramadol  (ISO)
trans-cinnamic acid  (ISO)
trichloroethene  (ISO)
triclosan  (ISO)
triphenyl phosphate  (EXP,ISO)
triphenylstannane  (ISO)
Triptolide  (EXP,ISO)
triptonide  (EXP)
tris(2-butoxyethyl) phosphate  (ISO)
tris(2-chloroethyl) phosphate  (EXP,ISO)
troglitazone  (ISO)
uranium atom  (ISO)
valdecoxib  (ISO)
valproic acid  (EXP,ISO)
venlafaxine hydrochloride  (ISO)
vinclozolin  (ISO)
zearalenone  (EXP,ISO)
ziram  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. CYP17 genetic polymorphism, breast cancer, and breast cancer risk factors. Ambrosone CB, etal., Breast Cancer Res. 2003;5(2):R45-51. Epub 2003 Jan 29.
2. Phase I clinical trial of a selective inhibitor of CYP17, abiraterone acetate, confirms that castration-resistant prostate cancer commonly remains hormone driven. Attard G, etal., J Clin Oncol. 2008 Oct 1;26(28):4563-71. Epub 2008 Jul 21.
3. Genetic variation in CYP17A1 and pancreatic cancer in a population-based case-control study in the San Francisco Bay Area, California. Duell EJ, etal., Int J Cancer. 2010 Feb 1;126(3):790-5.
4. Basic concepts and recent developments in human steroid hormone biosynthesis. Ghayee HK and Auchus RJ, Rev Endocr Metab Disord. 2007 Dec;8(4):289-300.
5. CYP17 MspA1 polymorphism and risk of biliary tract cancers and gallstones: a population-based study in Shanghai, China. Hou L, etal., Int J Cancer. 2006 Jun 1;118(11):2847-53.
6. Biochemical and functional evidence for the control of pain mechanisms by dehydroepiandrosterone endogenously synthesized in the spinal cord. Kibaly C, etal., FASEB J. 2008 Jan;22(1):93-104. Epub 2007 Aug 24.
7. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
8. MGDs mouse GO annotations MGD data from the GO Consortium
9. MGD IEA MGD IEA
10. Androgen synthesis in adrenarche. Miller WL Rev Endocr Metab Disord. 2009 Mar;10(1):3-17.
11. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, etal., Cell 2003 Nov 26;115(5):629-40.
12. The biochemical basis for increased testosterone production in theca cells propagated from patients with polycystic ovary syndrome. Nelson VL, etal., J Clin Endocrinol Metab. 2001 Dec;86(12):5925-33.
13. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
14. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
15. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
16. Mouse MP Annotation Import Pipeline RGD automated import pipeline
17. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Robust and comprehensive analysis of 20 osteoporosis candidate genes by very high-density single-nucleotide polymorphism screen among 405 white nuclear families identified significant association and gene-gene interaction. Xiong DH, etal., J Bone Miner Res. 2006 Nov;21(11):1678-95.
20. 17 alpha-hydroxylase/17,20-lyase deficiency: from clinical investigation to molecular definition. Yanase T, etal., Endocr Rev. 1991 Feb;12(1):91-108.
Additional References at PubMed
PMID:1323057   PMID:1478654   PMID:1840559   PMID:2848682   PMID:7476982   PMID:7479914   PMID:7588219   PMID:7588260   PMID:7588370   PMID:7628389   PMID:7719026   PMID:7835879  
PMID:7835908   PMID:7913464   PMID:7958412   PMID:8013361   PMID:8043950   PMID:8243812   PMID:8863187   PMID:8994191   PMID:9052933   PMID:9256466   PMID:9303351   PMID:9492048  
PMID:9989404   PMID:10029587   PMID:10349636   PMID:10436162   PMID:10441736   PMID:10847589   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11247667   PMID:11415992  
PMID:11544199   PMID:11919667   PMID:12193547   PMID:12223418   PMID:12399432   PMID:12446594   PMID:12466851   PMID:12477932   PMID:12617826   PMID:12745259   PMID:14610273   PMID:14681479  
PMID:15169901   PMID:15533830   PMID:15666818   PMID:15761033   PMID:15829514   PMID:15890676   PMID:15944188   PMID:16003771   PMID:16141072   PMID:16141073   PMID:16412416   PMID:16949566  
PMID:17270348   PMID:17592132   PMID:17890294   PMID:18250097   PMID:18287559   PMID:18583422   PMID:18642057   PMID:18832096   PMID:18927153   PMID:18927154   PMID:18981061   PMID:19268447  
PMID:19334288   PMID:19500726   PMID:19897027   PMID:20454446   PMID:20530532   PMID:21123943   PMID:21209421   PMID:21267068   PMID:21385577   PMID:21427128   PMID:21559465   PMID:21677750  
PMID:21873635   PMID:21900680   PMID:22116255   PMID:22217834   PMID:22217835   PMID:22294746   PMID:22402963   PMID:22496664   PMID:22649409   PMID:23087174   PMID:23136395   PMID:23274689  
PMID:23838579   PMID:24105479   PMID:24694307   PMID:24725081   PMID:24899578   PMID:25668066   PMID:25713029   PMID:25725066   PMID:25775596   PMID:25917826   PMID:25933105   PMID:26108225  
PMID:26108792   PMID:26333992   PMID:26362256   PMID:26470726   PMID:26697723   PMID:26974035   PMID:27339169   PMID:27498191   PMID:27621062   PMID:27626380   PMID:27732090   PMID:27734842  
PMID:28036337   PMID:28378742   PMID:28818950   PMID:28938467   PMID:29324782   PMID:29968852   PMID:30067986   PMID:30212841   PMID:30375389   PMID:30793514   PMID:31100714   PMID:31387001  
PMID:31835801   PMID:32274496   PMID:32294451   PMID:32325033   PMID:32472014   PMID:32497091   PMID:32945847   PMID:33127481   PMID:34007995   PMID:34070975   PMID:34288113   PMID:34654452  
PMID:35084365  


Genomics

Comparative Map Data
Cyp17a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391946,655,604 - 46,661,439 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1946,655,604 - 46,661,611 (-)EnsemblGRCm39 Ensembl
GRCm381946,667,165 - 46,673,000 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1946,667,165 - 46,673,172 (-)EnsemblGRCm38mm10GRCm38
MGSCv371946,741,655 - 46,747,490 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361946,720,491 - 46,726,285 (-)NCBIMGSCv36mm8
Celera1947,437,171 - 47,443,006 (-)NCBICelera
Cytogenetic Map19C3NCBI
cM Map1938.97NCBI
CYP17A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810102,830,531 - 102,837,413 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl10102,830,531 - 102,837,472 (-)EnsemblGRCh38hg38GRCh38
GRCh3710104,590,288 - 104,597,170 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3610104,580,278 - 104,587,280 (-)NCBINCBI36Build 36hg18NCBI36
Build 3410104,580,283 - 104,587,168NCBI
Celera1098,331,010 - 98,337,873 (-)NCBICelera
Cytogenetic Map10q24.32NCBI
HuRef1098,225,099 - 98,232,065 (-)NCBIHuRef
CHM1_110104,873,550 - 104,880,507 (-)NCBICHM1_1
T2T-CHM13v2.010103,716,316 - 103,723,198 (-)NCBIT2T-CHM13v2.0
Cyp17a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21245,535,462 - 245,543,148 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1245,535,462 - 245,541,573 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01266,422,127 - 266,429,947 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1266,422,132 - 266,428,239 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01273,852,163 - 273,859,866 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41251,965,458 - 251,971,449 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11252,228,608 - 252,234,604 (-)NCBI
Celera1241,321,307 - 241,327,254 (-)NCBICelera
RH 3.4 Map11626.0RGD
Cytogenetic Map1q54NCBI
LOC102011010
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554857,645,363 - 7,650,658 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554857,615,132 - 7,652,899 (+)NCBIChiLan1.0ChiLan1.0
CYP17A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.110102,891,280 - 102,901,963 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl10102,896,376 - 102,901,514 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01099,431,762 - 99,439,619 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
CYP17A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12815,292,959 - 15,298,896 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2815,293,106 - 15,298,852 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2815,464,817 - 15,470,751 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02815,766,953 - 15,772,955 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2815,764,529 - 15,772,909 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12815,310,874 - 15,316,795 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02815,350,683 - 15,356,605 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02815,483,290 - 15,489,212 (-)NCBIUU_Cfam_GSD_1.0
LOC101970767
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721331,494,353 - 31,499,609 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049366003,097,620 - 3,102,713 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CYP17A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14113,805,611 - 113,812,041 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114113,805,616 - 113,820,445 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214123,773,108 - 123,787,947 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CYP17A1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1995,870,098 - 95,877,345 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl995,866,908 - 95,877,180 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604856,981,761 - 56,989,146 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
LOC101726496
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248312,157,048 - 2,166,539 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248312,155,851 - 2,166,621 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Position Markers
M64863  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381946,667,217 - 46,667,335UniSTSGRCm38
MGSCv371946,741,707 - 46,741,825UniSTSGRCm37
Celera1947,437,223 - 47,437,341UniSTS
Cytogenetic Map19C3UniSTS
cM Map1946.0UniSTS
Whitehead/MRC_RH19461.51UniSTS
Cyp17  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381946,672,749 - 46,672,873UniSTSGRCm38
MGSCv371946,747,239 - 46,747,363UniSTSGRCm37
Celera1947,442,755 - 47,442,879UniSTS
Cytogenetic Map19C3UniSTS
cM Map1946.0UniSTS
Cyp17a1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map19C3UniSTS
Cyp17a1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map19C3UniSTS
Cyp17a1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381946,669,222 - 46,669,338UniSTSGRCm38
MGSCv371946,743,712 - 46,743,828UniSTSGRCm37
Celera1947,439,228 - 47,439,344UniSTS
Cytogenetic Map19C3UniSTS
Cyp17a1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map19C3UniSTS
Cyp17a1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381946,669,155 - 46,670,639UniSTSGRCm38
MGSCv371946,743,645 - 46,745,129UniSTSGRCm37
Celera1947,439,161 - 47,440,645UniSTS
Cytogenetic Map19C3UniSTS
Cyp17a1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381946,670,541 - 46,671,078UniSTSGRCm38
MGSCv371946,745,031 - 46,745,568UniSTSGRCm37
Celera1947,440,547 - 47,441,084UniSTS
Cytogenetic Map19C3UniSTS


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10413881Moe2_mmodifier of epilepsy 2 (mouse)191492301648923138Mouse
1301336Alcp23_malcohol preference locus 23 (mouse)Not determined191591260749912719Mouse
1301633Alcp24_malcohol preference locus 24 (mouse)Not determined191591260749912719Mouse
1302063Eae19_mexperimental allergic encephalomyelitis 19 (mouse)Not determined191829516252295381Mouse
1302004Lfp2_mlong free running period 2 (mouse)Not determined191829516252295381Mouse
4142343Moen2_mmodifier of engrailed QTL 2 (mouse)Not determined192023431454234461Mouse
10412251Mnp_mmodifier of Niemann Pick type C1 (mouse)Not determined192023431454234461Mouse
4141659Pbwg20_mpostnatal body weight growth 20 (mouse)Not determined192137870555378928Mouse
1558876W3q14_mweight 3 weeks QTL 14 (mouse)Not determined192231332653911504Mouse
12790634Ebm1_mEpidermolysis Bullosa modifier 1 (mouse)192498843958988439Mouse
1301451Ath16_matherosclerosis 16 (mouse)Not determined192542691759427005Mouse
13506250Renmq1_mrenal mercury accumulation QTL 1 (mouse)192738559461385705Mouse
4141138Femwf11_mfemur work to failure 11 (mouse)Not determined2814034861420004Mouse
1300683Fembm7_mfemoral bone morphometry 7 (mouse)Not determined193014122461420004Mouse
1301942Pas13_mpulmonary adenoma susceptibility 13 (mouse)Not determined193014123161420004Mouse
1301410Cd8mts6_mCD8 memory T cell subset 6 (mouse)Not determined193014123161420004Mouse
1300856Nobq2_mNew Zealand obese QTL 2 (mouse)Not determined193089788061420004Mouse
1301741Lith2_mlithogenic gene 2 (mouse)Not determined193299215861420004Mouse
1301639Stnn_mstriatal neuron number (mouse)Not determined193395195261420004Mouse
4141019Tgq29_mtriglyceride QTL 29 (mouse)Not determined3459678661420004Mouse
1301479Sluc1_msusceptibility to lung cancer 1 (mouse)Not determined193601694446761521Mouse
1302170Tanidd1_mtally ho associated non-insulin dependednt diabetes mellitus 1 (mouse)Not determined193675259761420004Mouse
4141650Chldq9_mcholesterol and HDL QTL 9 (mouse)Not determined193788298261420004Mouse
1301466T2dm2_mtype 2 diabetes mellitus 2 (mouse)Not determined193837605061420004Mouse
1302104Lfp1_mlong free running period 1 (mouse)Not determined193918406461420004Mouse
10043896Bw21_mbody weight QTL 21 (mouse)Not determined193959606661420004Mouse
1300585Pgia12_mproteoglycan induced arthritis 12 (mouse)Not determined194258685961420004Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:352
Count of miRNA genes:289
Interacting mature miRNAs:308
Transcripts:ENSMUST00000026012, ENSMUST00000131142, ENSMUST00000156577
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_007809 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC156982 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC161865 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK132830 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK134376 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY594330 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC064793 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CD552634 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466534 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570570 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570571 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570572 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570573 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570574 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570575 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570576 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570577 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570578 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570579 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570580 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570581 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570582 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570583 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570584 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570585 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570586 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570587 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570588 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570589 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570590 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570591 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570593 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570594 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570595 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570596 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570597 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM570598 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M64863 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S41708 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000026012   ⟹   ENSMUSP00000026012
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1946,655,604 - 46,661,413 (-)Ensembl
GRCm38.p6 Ensembl1946,667,165 - 46,672,974 (-)Ensembl
RefSeq Acc Id: ENSMUST00000131142
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1946,656,526 - 46,657,952 (-)Ensembl
GRCm38.p6 Ensembl1946,668,087 - 46,669,513 (-)Ensembl
RefSeq Acc Id: ENSMUST00000156577
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1946,659,165 - 46,659,730 (-)Ensembl
GRCm38.p6 Ensembl1946,670,726 - 46,671,291 (-)Ensembl
RefSeq Acc Id: ENSMUST00000236174   ⟹   ENSMUSP00000157718
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1946,655,619 - 46,661,611 (-)Ensembl
GRCm38.p6 Ensembl1946,667,180 - 46,673,172 (-)Ensembl
RefSeq Acc Id: NM_007809   ⟹   NP_031835
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391946,655,604 - 46,661,439 (-)NCBI
GRCm381946,667,165 - 46,673,000 (-)ENTREZGENE
MGSCv371946,741,655 - 46,747,490 (-)RGD
Celera1947,437,171 - 47,443,006 (-)RGD
cM Map19 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_031835   ⟸   NM_007809
- Peptide Label: precursor
- UniProtKB: P27786 (UniProtKB/Swiss-Prot),   Q3UYU1 (UniProtKB/TrEMBL),   Q53YJ1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000026012   ⟸   ENSMUST00000026012
RefSeq Acc Id: ENSMUSP00000157718   ⟸   ENSMUST00000236174

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P27786-F1-model_v2 AlphaFold P27786 1-507 view protein structure

Promoters
RGD ID:13679700
Promoter ID:EPDNEW_M23999
Type:multiple initiation site
Name:Cyp17a1_1
Description:Mus musculus cytochrome P450, family 17, subfamily a, polypeptide1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M24000  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381946,672,890 - 46,672,950EPDNEW
RGD ID:13679702
Promoter ID:EPDNEW_M24000
Type:initiation region
Name:Cyp17a1_2
Description:Mus musculus cytochrome P450, family 17, subfamily a, polypeptide1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M23999  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381946,673,068 - 46,673,128EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:88586 AgrOrtholog
Ensembl Genes ENSMUSG00000003555 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000026012 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000157718.2 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000026012 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000236174.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.630.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cyt_P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_E_grp-I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:13074 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:88586 ENTREZGENE
NCBI Gene 13074 ENTREZGENE
Pfam p450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cyp17a1 PhenoGen
PRINTS EP450I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CYTOCHROME_P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48264 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A494B9N2_MOUSE UniProtKB/TrEMBL
  CP17A_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3UYU1 ENTREZGENE, UniProtKB/TrEMBL
  Q53YJ1 ENTREZGENE, UniProtKB/TrEMBL
  Q6P200_MOUSE UniProtKB/TrEMBL