Acsl5 (acyl-CoA synthetase long-chain family member 5) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Acsl5 (acyl-CoA synthetase long-chain family member 5) Rattus norvegicus
Analyze
Symbol: Acsl5
Name: acyl-CoA synthetase long-chain family member 5
RGD ID: 69402
Description: Enables arachidonate-CoA ligase activity. Involved in several processes, including organophosphate biosynthetic process; positive regulation of lipid metabolic process; and positive regulation of long-chain fatty acid import across plasma membrane. Located in mitochondrion. Colocalizes with endoplasmic reticulum. Orthologous to human ACSL5 (acyl-CoA synthetase long chain family member 5); PARTICIPATES IN fatty acid beta degradation pathway; eicosanoid signaling pathway via peroxisome proliferator-activated receptor gamma; fatty acid metabolic pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Acs5; arachidonate--CoA ligase; Facl5; fatty acid Coenzyme A ligase, long chain 5; LACS 5; long-chain acyl-CoA synthetase 5; long-chain fatty acid coenzyme A ligase 5; long-chain-fatty-acid--CoA ligase 5
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21254,289,513 - 254,336,608 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1254,292,521 - 254,336,607 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1262,494,531 - 262,541,592 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01269,200,609 - 269,247,672 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01261,848,340 - 261,895,280 (+)NCBIRnor_WKY
Rnor_6.01276,240,703 - 276,290,012 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1276,240,703 - 276,290,008 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01283,637,899 - 283,685,361 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41261,554,383 - 261,599,373 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11261,765,427 - 261,810,418 (+)NCBI
Celera1249,999,118 - 250,043,312 (+)NCBICelera
Cytogenetic Map1q55NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',5-triiodo-L-thyronine  (EXP)
3-chloropropane-1,2-diol  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime  (ISO)
acetamide  (EXP)
aflatoxin B1  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arotinoid acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
ATP  (ISO)
azathioprine  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
bexarotene  (EXP)
bezafibrate  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
buspirone  (EXP)
cadmium atom  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
CHIR 99021  (ISO)
chlorpyrifos  (EXP)
cisplatin  (EXP)
clofibrate  (EXP,ISO)
cobalt dichloride  (EXP,ISO)
cocaine  (EXP)
copper(II) sulfate  (ISO)
cortisol  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
diethylstilbestrol  (EXP)
dioscin  (EXP,ISO)
doxorubicin  (ISO)
ethanol  (EXP,ISO)
farnesol  (ISO)
fenofibrate  (ISO)
flutamide  (EXP,ISO)
folic acid  (ISO)
gamma-hexachlorocyclohexane  (EXP)
gentamycin  (EXP)
GW 4064  (ISO)
GW 7647  (EXP,ISO)
hexadecanoic acid  (ISO)
isotretinoin  (ISO)
L-ascorbic acid  (ISO)
L-ascorbic acid 2-phosphate  (ISO)
levofloxacin  (EXP)
lithium atom  (EXP)
lithium hydride  (EXP)
methamphetamine  (EXP)
methidathion  (ISO)
methylmercury chloride  (ISO)
N-nitrosodiethylamine  (EXP)
nefazodone  (EXP)
nickel sulfate  (ISO)
nimesulide  (EXP)
O-methyleugenol  (ISO)
obeticholic acid  (ISO)
oleic acid  (ISO)
orphenadrine  (EXP)
oxaliplatin  (EXP)
oxybenzone  (EXP)
paracetamol  (EXP,ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
picrotoxin  (EXP)
pirinixic acid  (ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
propiconazole  (EXP)
quercetin  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
sotorasib  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (EXP)
thioacetamide  (EXP)
tolcapone  (ISO)
topotecan  (EXP)
trametinib  (ISO)
triphenyl phosphate  (EXP)
Triptolide  (ISO)
troglitazone  (EXP)
tunicamycin  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)
XAV939  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)
zoledronic acid  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Long chain fatty acyl-CoA synthetase 5 expression is induced by insulin and glucose: involvement of sterol regulatory element-binding protein-1c. Achouri Y, etal., Biochimie. 2005 Dec;87(12):1149-55. Epub 2005 Sep 20.
2. Rat long chain acyl-CoA synthetase 5, but not 1, 2, 3, or 4, complements Escherichia coli fadD. Caviglia JM, etal., J Biol Chem. 2004 Mar 19;279(12):11163-9. Epub 2004 Jan 7.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
5. Expression and characterization of recombinant rat Acyl-CoA synthetases 1, 4, and 5. Selective inhibition by triacsin C and thiazolidinediones. Kim JH, etal., J Biol Chem 2001 Jul 6;276(27):24667-73.
6. Long-chain acyl-CoA synthetase isoforms differ in preferences for eicosanoid species and long-chain fatty acids. Klett EL, etal., J Lipid Res. 2017 May;58(5):884-894. doi: 10.1194/jlr.M072512. Epub 2017 Feb 16.
7. Rat liver acyl-CoA synthetase 4 is a peripheral-membrane protein located in two distinct subcellular organelles, peroxisomes, and mitochondrial-associated membrane. Lewin TM, etal., Arch Biochem Biophys. 2002 Aug 15;404(2):263-70.
8. Acyl-CoA synthetase isoforms 1, 4, and 5 are present in different subcellular membranes in rat liver and can be inhibited independently. Lewin TM, etal., J Biol Chem 2001 Jul 6;276(27):24674-9.
9. Rat long chain acyl-CoA synthetase 5 increases fatty acid uptake and partitioning to cellular triacylglycerol in McArdle-RH7777 cells. Mashek DG, etal., J Biol Chem. 2006 Jan 13;281(2):945-50. Epub 2005 Nov 1.
10. Rat long-chain acyl-CoA synthetase mRNA, protein, and activity vary in tissue distribution and in response to diet. Mashek DG, etal., J Lipid Res. 2006 Sep;47(9):2004-10. Epub 2006 Jun 13.
11. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
12. The Sjögren-Larsson syndrome gene encodes a hexadecenal dehydrogenase of the sphingosine 1-phosphate degradation pathway. Nakahara K, etal., Mol Cell. 2012 May 25;46(4):461-71. doi: 10.1016/j.molcel.2012.04.033.
13. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
14. A novel acyl-CoA synthetase, ACS5, expressed in intestinal epithelial cells and proliferating preadipocytes. Oikawa E, etal., J Biochem (Tokyo) 1998 Sep;124(3):679-85.
15. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
16. GOA pipeline RGD automated data pipeline
17. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
20. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
21. Fatty acid transport by vectorial acylation in mammals: roles played by different isoforms of rat long-chain acyl-CoA synthetases. Tong F, etal., Arch Biochem Biophys. 2006 Mar 1;447(1):46-52. Epub 2006 Jan 23.
22. Evidence for 26 distinct acyl-coenzyme A synthetase genes in the human genome. Watkins PA, etal., J Lipid Res. 2007 Dec;48(12):2736-50. Epub 2007 Aug 30.
Additional References at PubMed
PMID:12865426   PMID:14651853   PMID:17681178   PMID:18614015   PMID:19946888   PMID:20798351   PMID:22171129   PMID:24269233  


Genomics

Comparative Map Data
Acsl5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21254,289,513 - 254,336,608 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1254,292,521 - 254,336,607 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1262,494,531 - 262,541,592 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01269,200,609 - 269,247,672 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01261,848,340 - 261,895,280 (+)NCBIRnor_WKY
Rnor_6.01276,240,703 - 276,290,012 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1276,240,703 - 276,290,008 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01283,637,899 - 283,685,361 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41261,554,383 - 261,599,373 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11261,765,427 - 261,810,418 (+)NCBI
Celera1249,999,118 - 250,043,312 (+)NCBICelera
Cytogenetic Map1q55NCBI
ACSL5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810112,374,116 - 112,428,376 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl10112,374,116 - 112,428,379 (+)EnsemblGRCh38hg38GRCh38
GRCh3710114,133,874 - 114,188,134 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3610114,123,906 - 114,178,128 (+)NCBINCBI36Build 36hg18NCBI36
Celera10107,861,444 - 107,915,662 (+)NCBICelera
Cytogenetic Map10q25.2NCBI
HuRef10107,761,898 - 107,815,784 (+)NCBIHuRef
CHM1_110114,415,634 - 114,469,870 (+)NCBICHM1_1
T2T-CHM13v2.010113,265,142 - 113,319,056 (+)NCBIT2T-CHM13v2.0
Acsl5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391955,240,298 - 55,285,060 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1955,240,370 - 55,286,152 (+)EnsemblGRCm39 Ensembl
GRCm381955,251,861 - 55,296,628 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1955,251,938 - 55,297,720 (+)EnsemblGRCm38mm10GRCm38
MGSCv371955,327,859 - 55,371,118 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361955,306,619 - 55,349,878 (+)NCBIMGSCv36mm8
Celera1957,444,332 - 57,487,767 (+)NCBICelera
Cytogenetic Map19D2NCBI
Acsl5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543117,477,086 - 17,524,539 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543117,477,113 - 17,524,539 (+)NCBIChiLan1.0ChiLan1.0
ACSL5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.110112,405,069 - 112,457,892 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl10112,407,161 - 112,457,892 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v010108,965,559 - 109,019,240 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
ACSL5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12823,437,838 - 23,478,763 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2823,440,387 - 23,478,762 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2823,589,635 - 23,630,543 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02823,970,117 - 24,011,237 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2823,971,931 - 24,069,062 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12823,527,397 - 23,568,302 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02823,538,540 - 23,579,462 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02823,737,237 - 23,775,914 (+)NCBIUU_Cfam_GSD_1.0
Acsl5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721322,569,123 - 22,610,342 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364862,967,522 - 2,991,154 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049364862,952,379 - 2,992,148 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACSL5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14122,777,130 - 122,828,052 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114122,777,135 - 122,828,054 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214133,689,844 - 133,751,494 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ACSL5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.19105,259,546 - 105,311,500 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl9105,257,429 - 105,311,690 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604866,462,251 - 66,514,618 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Acsl5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473734,038,518 - 34,091,661 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473734,038,610 - 34,091,579 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Acsl5
146 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:179
Count of miRNA genes:129
Interacting mature miRNAs:145
Transcripts:ENSRNOT00000022126
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1156677124256448636Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1176426412257976495Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1177227632256448636Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1177227632256448636Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1179567751260522016Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1195804352257091168Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1199050459259647894Rat
1358890Bp259Blood pressure QTL 2593.06arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1210702053260522016Rat
734768Niddm59Non-insulin dependent diabetes mellitus QTL 59body mass (VT:0001259)body weight (CMO:0000012)1213843987258843987Rat
70211Niddm24Non-insulin dependent diabetes mellitus QTL 243.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1214647894259647894Rat
1549910Bw54Body weight QTL 540.05body mass (VT:0001259)body weight (CMO:0000012)1214647894259647894Rat
61327Eae7Experimental allergic encephalomyelitis QTL 75.6body mass (VT:0001259)change in body weight (CMO:0002045)1216255568260522016Rat
2302040Pia35Pristane induced arthritis QTL 353.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1216255568260522016Rat
1598821Rf55Renal function QTL 556.3renal blood flow trait (VT:2000006)ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)1218748008257976495Rat
724533Rf51Renal function QTL 515.30.0002kidney plasma flow trait (VT:0005524)renal plasma flow (CMO:0001914)1218753816256448513Rat
731175Uae20Urinary albumin excretion QTL 203.50.0018urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1221264111259647894Rat
10053715Scort24Serum corticosterone level QTL 242.130.0088blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1221414816260522016Rat
724552Glom2Glomerulus QTL 23.30.0001kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)1222363780260522016Rat
1600392Bw123Body weight QTL 1230.001body mass (VT:0001259)body weight (CMO:0000012)1223201027260522016Rat
734767Niddm57Non-insulin dependent diabetes mellitus QTL 57body mass (VT:0001259)body weight (CMO:0000012)1224054293260122809Rat
631843Bw116Body weight QTL 1164.10.016abdominal adipose amount (VT:1000220)abdominal fat pad weight (CMO:0000088)1224054293260122809Rat
734769Niddm58Non-insulin dependent diabetes mellitus QTL 58body mass (VT:0001259)body weight (CMO:0000012)1224569538260122809Rat
631215Stl8Serum triglyceride level QTL 89.270.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1225126575260522016Rat
1300108Rf8Renal function QTL 83.75renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)1228581588259647894Rat
1581544Rf52Renal function QTL 520.05urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)1232156370259647894Rat
631669Iddm9Insulin dependent diabetes mellitus QTL 92.80.039blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1233190394258625266Rat
631536Lnnr2Liver neoplastic nodule remodeling QTL 22.90.0005liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)1233948574260522016Rat
631690Scl5Serum cholesterol level QTL 52.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1236125214260522016Rat
631836Stl31Serum triglyceride level QTL 314.640.00000487blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1237147813260522016Rat
631837Niddm35Non-insulin dependent diabetes mellitus QTL 350.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1238699859259647894Rat
1598839Rf56Renal function QTL 56renal blood flow trait (VT:2000006)ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)1245907761257976495Rat

Markers in Region
D1Rat456  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21254,304,565 - 254,304,772 (+)MAPPERmRatBN7.2
Rnor_6.01276,258,539 - 276,258,745NCBIRnor6.0
Rnor_5.01283,654,821 - 283,655,027UniSTSRnor5.0
RGSC_v3.41261,566,459 - 261,566,666RGDRGSC3.4
RGSC_v3.41261,566,460 - 261,566,666UniSTSRGSC3.4
RGSC_v3.11261,777,504 - 261,777,711RGD
Celera1250,011,271 - 250,011,477UniSTS
SHRSP x BN Map1143.5499RGD
SHRSP x BN Map1143.5499UniSTS
Cytogenetic Map1q55UniSTS
RH132400  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21254,336,366 - 254,336,571 (+)MAPPERmRatBN7.2
Rnor_6.01276,289,771 - 276,289,975NCBIRnor6.0
Rnor_5.01283,685,126 - 283,685,330UniSTSRnor5.0
RGSC_v3.41261,599,138 - 261,599,342UniSTSRGSC3.4
Celera1250,043,077 - 250,043,281UniSTS
RH 3.4 Map11650.3UniSTS
Cytogenetic Map1q55UniSTS
BE097769  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21254,294,052 - 254,294,206 (+)MAPPERmRatBN7.2
Rnor_6.01276,242,350 - 276,242,503NCBIRnor6.0
Rnor_5.01283,639,546 - 283,639,699UniSTSRnor5.0
RGSC_v3.41261,556,030 - 261,556,183UniSTSRGSC3.4
Celera1250,000,765 - 250,000,918UniSTS
RH 3.4 Map11651.5UniSTS
Cytogenetic Map1q55UniSTS
Acsl5  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21254,331,296 - 254,331,569 (+)MAPPERmRatBN7.2
Rnor_6.01276,284,701 - 276,284,973NCBIRnor6.0
Rnor_5.01283,680,056 - 283,680,328UniSTSRnor5.0
RGSC_v3.41261,594,068 - 261,594,340UniSTSRGSC3.4
Celera1250,038,007 - 250,038,279UniSTS
Cytogenetic Map1q55UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 2 2 74 35 40 11 2
Low 6 9 1 6
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000022126   ⟹   ENSRNOP00000022126
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1254,295,124 - 254,336,602 (+)Ensembl
Rnor_6.0 Ensembl1276,240,703 - 276,290,008 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000098395   ⟹   ENSRNOP00000095186
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1254,294,252 - 254,336,605 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000103067   ⟹   ENSRNOP00000092211
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1254,293,882 - 254,335,106 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000103178   ⟹   ENSRNOP00000090718
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1254,292,521 - 254,336,607 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000109824   ⟹   ENSRNOP00000078386
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1254,293,882 - 254,336,598 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000110033   ⟹   ENSRNOP00000080415
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1254,293,882 - 254,336,598 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000112922   ⟹   ENSRNOP00000078938
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1254,293,882 - 254,336,598 (+)Ensembl
RefSeq Acc Id: NM_053607   ⟹   NP_446059
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21254,292,406 - 254,336,602 (+)NCBI
Rnor_6.01276,240,703 - 276,290,006 (+)NCBI
Rnor_5.01283,637,899 - 283,685,361 (+)NCBI
RGSC_v3.41261,554,383 - 261,599,373 (+)RGD
Celera1249,999,118 - 250,043,312 (+)RGD
Sequence:
RefSeq Acc Id: XM_039093157   ⟹   XP_038949085
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21254,293,624 - 254,336,601 (+)NCBI
RefSeq Acc Id: XM_039093161   ⟹   XP_038949089
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21254,289,513 - 254,336,608 (+)NCBI
RefSeq Acc Id: XM_039093168   ⟹   XP_038949096
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21254,294,762 - 254,336,601 (+)NCBI
RefSeq Acc Id: XM_039093173   ⟹   XP_038949101
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21254,308,841 - 254,336,601 (+)NCBI
RefSeq Acc Id: XM_039093177   ⟹   XP_038949105
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21254,307,850 - 254,336,601 (+)NCBI
RefSeq Acc Id: XM_039093181   ⟹   XP_038949109
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21254,293,623 - 254,336,608 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_446059   ⟸   NM_053607
- UniProtKB: Q6IN15 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000022126   ⟸   ENSRNOT00000022126
RefSeq Acc Id: XP_038949089   ⟸   XM_039093161
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038949109   ⟸   XM_039093181
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038949085   ⟸   XM_039093157
- Peptide Label: isoform X1
- UniProtKB: Q6IN15 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038949096   ⟸   XM_039093168
- Peptide Label: isoform X1
- UniProtKB: Q6IN15 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038949105   ⟸   XM_039093177
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038949101   ⟸   XM_039093173
- Peptide Label: isoform X2
RefSeq Acc Id: ENSRNOP00000090718   ⟸   ENSRNOT00000103178
RefSeq Acc Id: ENSRNOP00000095186   ⟸   ENSRNOT00000098395
RefSeq Acc Id: ENSRNOP00000078938   ⟸   ENSRNOT00000112922
RefSeq Acc Id: ENSRNOP00000080415   ⟸   ENSRNOT00000110033
RefSeq Acc Id: ENSRNOP00000078386   ⟸   ENSRNOT00000109824
RefSeq Acc Id: ENSRNOP00000092211   ⟸   ENSRNOT00000103067
Protein Domains
AMP-binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O88813-F1-model_v2 AlphaFold O88813 1-683 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690998
Promoter ID:EPDNEW_R1523
Type:initiation region
Name:Acsl5_1
Description:acyl-CoA synthetase long-chain family member 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01276,240,698 - 276,240,758EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69402 AgrOrtholog
BioCyc Gene G2FUF-55346 BioCyc
BioCyc Pathway FAO-PWY [fatty acid beta-oxidation I (generic)] BioCyc
  PWY-5143 [long-chain fatty acid activation] BioCyc
  PWY-5972 [stearate biosynthesis I (animals)] BioCyc
  PWY-6000 [gamma-linolenate biosynthesis II (animals)] BioCyc
  PWY-7049 [icosapentaenoate biosynthesis II (6-desaturase, mammals)] BioCyc
  PWY-8181 [2-methyl-branched fatty acid beta-oxidation] BioCyc
  PWY3DJ-11470 [sphingosine and sphingosine-1-phosphate metabolism] BioCyc
  PWY66-387 [3-methyl-branched fatty acid alpha-oxidation] BioCyc
  PWY66-388 [ceramide degradation by alpha-oxidation] BioCyc
  PWY66-389 [phytol degradation] BioCyc
  PWY66-391 [fatty acid beta-oxidation VI (mammalian peroxisome)] BioCyc
Ensembl Genes ENSRNOG00000016265 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000022126 ENTREZGENE
  ENSRNOP00000022126.7 UniProtKB/TrEMBL
  ENSRNOP00000078386.1 UniProtKB/TrEMBL
  ENSRNOP00000078938.1 UniProtKB/TrEMBL
  ENSRNOP00000080415 ENTREZGENE
  ENSRNOP00000080415.1 UniProtKB/TrEMBL
  ENSRNOP00000090718 ENTREZGENE
  ENSRNOP00000090718.1 UniProtKB/TrEMBL
  ENSRNOP00000092211.1 UniProtKB/TrEMBL
  ENSRNOP00000095186.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000022126 ENTREZGENE
  ENSRNOT00000022126.7 UniProtKB/TrEMBL
  ENSRNOT00000098395.1 UniProtKB/TrEMBL
  ENSRNOT00000103067.1 UniProtKB/TrEMBL
  ENSRNOT00000103178 ENTREZGENE
  ENSRNOT00000103178.1 UniProtKB/TrEMBL
  ENSRNOT00000109824.1 UniProtKB/TrEMBL
  ENSRNOT00000110033 ENTREZGENE
  ENSRNOT00000110033.1 UniProtKB/TrEMBL
  ENSRNOT00000112922.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.12780 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7096959 IMAGE-MGC_LOAD
InterPro AMP-binding_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AMP-dep_Synth/Lig UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ANL_N_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LC-FACS_euk UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:94340 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:91566 IMAGE-MGC_LOAD
NCBI Gene 94340 ENTREZGENE
Pfam AMP-binding UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Acsl5 PhenoGen
PROSITE AMP_BINDING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC216611
UniProt A0A8I5ZKT4_RAT UniProtKB/TrEMBL
  A0A8I5ZM08_RAT UniProtKB/TrEMBL
  A0A8I6AAN7_RAT UniProtKB/TrEMBL
  A0A8I6AHE5_RAT UniProtKB/TrEMBL
  A0A8I6GLI0_RAT UniProtKB/TrEMBL
  ACSL5_RAT UniProtKB/Swiss-Prot
  F1LPB3_RAT UniProtKB/TrEMBL
  O88813 ENTREZGENE
  Q6IN15 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Acsl5  acyl-CoA synthetase long-chain family member 5  Facl5  fatty acid Coenzyme A ligase, long chain 5  Symbol and Name updated 1299863 APPROVED
2002-06-10 Facl5  fatty acid Coenzyme A ligase, long chain 5      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function catalyzes the ligation of long chain fatty acids with coenzyme A to produce long chain acyl-CoAs, has a broad substrate specificity for saturated fatty acids of 1218 carbon atoms and unsaturated fatty acids of 1620 carbon atoms 69375
gene_process involved in energy use via b-oxidation and the synthesis of triacylglycerol, phospholipids, cholesterol esters, and sphingomyelin 69375
gene_process may be critical for recycling arachidonate into phospholipids that are sources for signaling molecules related to intellect and coordination 69375