Pax2 (paired box 2) - Rat Genome Database

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Gene: Pax2 (paired box 2) Rattus norvegicus
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Symbol: Pax2
Name: paired box 2
RGD ID: 1305568
Description: Predicted to enable C2H2 zinc finger domain binding activity; DNA-binding transcription factor activity, RNA polymerase II-specific; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in cellular response to epidermal growth factor stimulus; positive regulation of cell population proliferation; and response to nutrient levels. Predicted to be located in centriolar satellite and nucleoplasm. Predicted to be part of protein-DNA complex. Biomarker of nephroblastoma. Human ortholog(s) of this gene implicated in focal segmental glomerulosclerosis 7; renal Wilms' tumor; and renal coloboma syndrome. Orthologous to human PAX2 (paired box 2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; atrazine; bis(2-ethylhexyl) phthalate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC293992; paired box gene 2; paired box homeotic gene 2; paired box protein 2; paired box protein Pax-2; Pax-2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81253,555,447 - 253,646,623 (+)NCBIGRCr8
mRatBN7.21243,616,509 - 243,697,454 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1243,616,606 - 243,695,321 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1251,764,024 - 251,843,009 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01258,462,042 - 258,540,874 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01251,113,975 - 251,192,959 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01264,493,579 - 264,585,073 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1264,504,591 - 264,583,329 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01271,936,269 - 272,027,514 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41249,804,055 - 249,895,306 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11250,026,899 - 250,155,758 (+)NCBI
Celera1239,428,164 - 239,506,765 (+)NCBICelera
Cytogenetic Map1q54NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
brain morphogenesis  (ISO,ISS)
branching involved in ureteric bud morphogenesis  (ISO,ISS)
camera-type eye development  (ISO,ISS)
cell fate determination  (ISO,ISS)
cellular response to epidermal growth factor stimulus  (IEP)
cellular response to glucose stimulus  (ISO,ISS)
cellular response to hydrogen peroxide  (ISO,ISS)
cellular response to mechanical stimulus  (ISO)
cellular response to retinoic acid  (ISO,ISS)
central nervous system development  (ISO)
cochlea development  (ISO,ISS)
cochlea morphogenesis  (ISO,ISS)
glial cell differentiation  (ISO,ISS)
inner ear morphogenesis  (ISO,ISS)
kidney development  (ISO)
mesenchymal to epithelial transition  (ISO,ISS)
mesenchymal to epithelial transition involved in metanephros morphogenesis  (ISO,ISS)
mesodermal cell fate specification  (ISO,ISS)
mesonephric duct development  (ISO)
mesonephric tubule development  (ISO)
mesonephric tubule formation  (ISO)
mesonephros development  (ISO,ISS)
metanephric collecting duct development  (ISO,ISS)
metanephric distal convoluted tubule development  (ISO,ISS)
metanephric epithelium development  (ISO)
metanephric mesenchymal cell differentiation  (ISO,ISS)
metanephric mesenchyme development  (ISO,ISS)
metanephric nephron tubule formation  (ISO,ISS)
metanephros development  (ISO)
negative regulation of apoptotic process  (ISO,ISS)
negative regulation of apoptotic process involved in metanephric collecting duct development  (ISO,ISS)
negative regulation of apoptotic process involved in metanephric nephron tubule development  (ISO,ISS)
negative regulation of DNA-templated transcription  (ISO,ISS)
negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis  (ISO,ISS)
negative regulation of mesenchymal cell apoptotic process involved in metanephros development  (ISO,ISS)
negative regulation of programmed cell death  (ISO,ISS)
negative regulation of reactive oxygen species metabolic process  (ISO,ISS)
negative regulation of transcription by RNA polymerase II  (ISO)
nephric duct formation  (ISO,ISS)
neural tube closure  (ISO,ISS)
optic chiasma development  (ISO,ISS)
optic cup morphogenesis involved in camera-type eye development  (ISO,ISS)
optic nerve development  (ISO,ISS)
optic nerve morphogenesis  (ISO,ISS)
optic nerve structural organization  (ISO,ISS)
pancreas development  (ISO)
paramesonephric duct development  (ISO)
phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO,ISS)
positive regulation of branching involved in ureteric bud morphogenesis  (ISO,ISS)
positive regulation of cell population proliferation  (IMP)
positive regulation of DNA-templated transcription  (ISO,ISS)
positive regulation of epithelial cell proliferation  (ISO)
positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis  (ISO,ISS)
positive regulation of metanephric DCT cell differentiation  (ISO,ISS)
positive regulation of metanephric glomerulus development  (ISO,ISS)
positive regulation of optic nerve formation  (ISO,ISS)
positive regulation of transcription by RNA polymerase II  (ISO,ISS)
pronephric field specification  (ISO,ISS)
pronephros development  (ISO,ISS)
reactive oxygen species metabolic process  (ISO,ISS)
regulation of apoptotic process  (ISO)
regulation of metanephric nephron tubule epithelial cell differentiation  (ISO,ISS)
regulation of metanephros size  (ISO,ISS)
regulation of programmed cell death  (ISO)
regulation of transcription by RNA polymerase II  (IBA)
response to nutrient levels  (IEP)
retinal pigment epithelium development  (ISO,ISS)
stem cell differentiation  (ISO,ISS)
ureter development  (ISO,ISS)
ureter maturation  (ISO,ISS)
ureter morphogenesis  (ISO)
ureteric bud development  (ISO)
urogenital system development  (ISO,ISS)
vestibulocochlear nerve formation  (ISO,ISS)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Mechanisms of impaired nephrogenesis with fetal growth restriction: altered renal transcription and growth factor expression. Abdel-Hakeem AK, etal., Am J Obstet Gynecol. 2008 Sep;199(3):252.e1-7. Epub 2008 Jul 17.
2. A mechanism regulating proteolysis of specific proteins during renal tubular cell growth. Franch HA, etal., J Biol Chem. 2001 Jun 1;276(22):19126-31. Epub 2001 Mar 21.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Gene expression in Wilms' tumor mimics the earliest committed stage in the metanephric mesenchymal-epithelial transition. Li CM, etal., Am J Pathol. 2002 Jun;160(6):2181-90.
6. Involvement of Pax-2 in the action of activin A on tubular cell regeneration. Maeshima A, etal., J Am Soc Nephrol 2002 Dec;13(12):2850-9.
7. Aging-related changes in astrocytes in the rat retina: imbalance between cell proliferation and cell death reduces astrocyte availability. Mansour H, etal., Aging Cell. 2008 Aug;7(4):526-40. Epub 2008 Jun 28.
8. Accumulation of malignant renal stem cells is associated with epigenetic changes in normal renal progenitor genes. Metsuyanim S, etal., Stem Cells. 2008 Jul;26(7):1808-17. doi: 10.1634/stemcells.2007-0322. Epub 2008 May 8.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
11. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Therapeutic potential of human induced pluripotent stem cells and renal progenitor cells in experimental chronic kidney disease. Ribeiro PC, etal., Stem Cell Res Ther. 2020 Dec 9;11(1):530. doi: 10.1186/s13287-020-02060-4.
15. A rodent model for Wilms tumors: embryonal kidney neoplasms induced by N-nitroso-N'-methylurea. Sharma PM, etal., Proc Natl Acad Sci U S A. 1994 Oct 11;91(21):9931-5.
16. Suppression of chaperone-mediated autophagy in the renal cortex during acute diabetes mellitus. Sooparb S, etal., Kidney Int. 2004 Jun;65(6):2135-44.
17. Angiotensin II stimulates Pax-2 in rat kidney proximal tubular cells: impact on proliferation and apoptosis. Zhang SL, etal., Kidney Int. 2004 Dec;66(6):2181-92.
Additional References at PubMed
PMID:1337742   PMID:1723950   PMID:7720589   PMID:7856737   PMID:8413205   PMID:8575306   PMID:8951055   PMID:9178767   PMID:10322633   PMID:10536059   PMID:10980123   PMID:11731455  
PMID:11940591   PMID:12200151   PMID:12435636   PMID:12756174   PMID:14695376   PMID:15153556   PMID:15242798   PMID:15905411   PMID:16018995   PMID:16319112   PMID:16368682   PMID:16672320  
PMID:16735463   PMID:16916509   PMID:17047028   PMID:17164400   PMID:17166926   PMID:17300925   PMID:17314325   PMID:17357786   PMID:17513325   PMID:17538188   PMID:17785448   PMID:17881463  
PMID:18000879   PMID:18083586   PMID:18607644   PMID:19037705   PMID:19048125   PMID:19118900   PMID:20171952   PMID:20486844   PMID:20727173   PMID:21731775   PMID:21778682   PMID:23107969  
PMID:23503776   PMID:24471428   PMID:24676634   PMID:24710423   PMID:27939388   PMID:29280536   PMID:30117015  


Genomics

Comparative Map Data
Pax2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81253,555,447 - 253,646,623 (+)NCBIGRCr8
mRatBN7.21243,616,509 - 243,697,454 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1243,616,606 - 243,695,321 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1251,764,024 - 251,843,009 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01258,462,042 - 258,540,874 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01251,113,975 - 251,192,959 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01264,493,579 - 264,585,073 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1264,504,591 - 264,583,329 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01271,936,269 - 272,027,514 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41249,804,055 - 249,895,306 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11250,026,899 - 250,155,758 (+)NCBI
Celera1239,428,164 - 239,506,765 (+)NCBICelera
Cytogenetic Map1q54NCBI
PAX2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810100,735,396 - 100,829,944 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl10100,735,396 - 100,829,944 (+)EnsemblGRCh38hg38GRCh38
GRCh3710102,495,153 - 102,589,701 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3610102,495,458 - 102,579,688 (+)NCBINCBI36Build 36hg18NCBI36
Build 3410102,495,321 - 102,579,687NCBI
Celera1096,243,249 - 96,327,456 (+)NCBICelera
Cytogenetic Map10q24.31NCBI
HuRef1096,133,870 - 96,218,089 (+)NCBIHuRef
CHM1_110102,789,756 - 102,873,990 (+)NCBICHM1_1
T2T-CHM13v2.010101,618,753 - 101,713,301 (+)NCBIT2T-CHM13v2.0
Pax2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391944,735,040 - 44,826,708 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1944,744,484 - 44,826,310 (+)EnsemblGRCm39 Ensembl
GRCm381944,746,601 - 44,838,269 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1944,756,045 - 44,837,871 (+)EnsemblGRCm38mm10GRCm38
MGSCv371944,831,884 - 44,910,517 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361944,810,705 - 44,889,338 (+)NCBIMGSCv36mm8
Celera1945,528,146 - 45,605,640 (+)NCBICelera
Cytogenetic Map19C3NCBI
cM Map1938.09NCBI
Pax2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554859,350,087 - 9,430,607 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554859,351,913 - 9,430,607 (-)NCBIChiLan1.0ChiLan1.0
PAX2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28112,618,587 - 112,713,001 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110112,623,907 - 112,718,321 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01097,344,978 - 97,429,086 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.110100,822,676 - 100,904,065 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl10100,822,676 - 100,904,028 (+)Ensemblpanpan1.1panPan2
PAX2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12813,442,894 - 13,519,853 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2813,442,893 - 13,532,094 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2813,606,001 - 13,692,205 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02813,904,432 - 13,990,703 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2813,900,260 - 13,992,558 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12813,450,612 - 13,536,833 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02813,492,258 - 13,578,015 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02813,623,521 - 13,709,771 (+)NCBIUU_Cfam_GSD_1.0
Pax2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721333,215,941 - 33,325,282 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366004,850,552 - 4,928,214 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366004,850,594 - 4,939,010 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PAX2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14111,823,308 - 111,913,969 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114111,822,334 - 111,914,950 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214121,481,577 - 121,574,679 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103216393
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1993,763,975 - 93,847,180 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604854,813,496 - 54,880,591 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pax2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624831375,866 - 453,930 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624831375,851 - 453,968 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pax2
290 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:70
Count of miRNA genes:65
Interacting mature miRNAs:69
Transcripts:ENSRNOT00000050076
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1150700142252085212Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1150700247252085048Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1156677124256448636Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393243914901Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1176426412257976495Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1177227632256448636Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1177227632256448636Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1179567751260522016Rat
8655655Arrd2Age-related retinal degeneration QTL 27.79retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1183970203243914901Rat
8655855Arrd3Age-related retinal degeneration QTL 33.07lens clarity trait (VT:0001304)cataract incidence/prevalence measurement (CMO:0001585)1183970203243914901Rat
1358898Bp255Blood pressure QTL 2553.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1191019702246062233Rat
1358191Ept10Estrogen-induced pituitary tumorigenesis QTL 103.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)1192825253243914732Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1195804352257091168Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1199050459259647894Rat
2293694Bss38Bone structure and strength QTL 387.050.0001femur strength trait (VT:0010010)femur stiffness (CMO:0001674)1201554356246554356Rat
7394701Uae46Urinary albumin excretion QTL 463.60.0056urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1201554356246554356Rat
2300175Bmd40Bone mineral density QTL 4015.40.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)1201554356246554356Rat
2293655Bss36Bone structure and strength QTL 3610.660.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1201554356246554356Rat
2293674Bss39Bone structure and strength QTL 397.10.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)1201554356246554356Rat
10059587Bw173Body weight QTL 1733.230.025body mass (VT:0001259)body weight (CMO:0000012)1202069611247069611Rat
1600363Hc6Hypercalciuria QTL 62.7urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1203995416244113296Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1206081677251081677Rat
1357399Bw45Body weight QTL 453.05body mass (VT:0001259)body mass index (BMI) (CMO:0000105)1206329708251329708Rat
1357404Bw42Body weight QTL 424.490.0001body mass (VT:0001259)body weight (CMO:0000012)1206329708251329708Rat
1358890Bp259Blood pressure QTL 2593.06arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1210702053260522016Rat
2292216Bw80Body weight QTL 803.230.0019body mass (VT:0001259)body weight (CMO:0000012)1213533809243914901Rat
724538Kidm1Kidney mass QTL 13.2kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1213707201252085212Rat
734768Niddm59Non-insulin dependent diabetes mellitus QTL 59body mass (VT:0001259)body weight (CMO:0000012)1213843987258843987Rat
70211Niddm24Non-insulin dependent diabetes mellitus QTL 243.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1214647894259647894Rat
1549910Bw54Body weight QTL 540.05body mass (VT:0001259)body weight (CMO:0000012)1214647894259647894Rat
61327Eae7Experimental allergic encephalomyelitis QTL 75.6body mass (VT:0001259)change in body weight (CMO:0002045)1216255568260522016Rat
2302040Pia35Pristane induced arthritis QTL 353.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1216255568260522016Rat
1598821Rf55Renal function QTL 556.3renal blood flow trait (VT:2000006)ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)1218748008257976495Rat
61400Niddm1Non-insulin dependent diabetes mellitus QTL 111blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1218753689245907899Rat
724533Rf51Renal function QTL 515.30.0002kidney plasma flow trait (VT:0005524)renal plasma flow (CMO:0001914)1218753816256448513Rat
731175Uae20Urinary albumin excretion QTL 203.50.0018urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1221264111259647894Rat
10053715Scort24Serum corticosterone level QTL 242.130.0088blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1221414816260522016Rat
724552Glom2Glomerulus QTL 23.30.0001kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)1222363780260522016Rat
1600392Bw123Body weight QTL 1230.001body mass (VT:0001259)body weight (CMO:0000012)1223201027260522016Rat
2293700Bmd27Bone mineral density QTL 276.60.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1224054293243747962Rat
2293701Bmd34Bone mineral density QTL 348.30.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)1224054293243747962Rat
734767Niddm57Non-insulin dependent diabetes mellitus QTL 57body mass (VT:0001259)body weight (CMO:0000012)1224054293260122809Rat
631843Bw116Body weight QTL 1164.10.016abdominal adipose amount (VT:1000220)abdominal fat pad weight (CMO:0000088)1224054293260122809Rat
734769Niddm58Non-insulin dependent diabetes mellitus QTL 58body mass (VT:0001259)body weight (CMO:0000012)1224569538260122809Rat
631215Stl8Serum triglyceride level QTL 89.270.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1225126575260522016Rat
1300108Rf8Renal function QTL 83.75renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)1228581588259647894Rat
2316896Gluco57Glucose level QTL 577.2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1228985440245907899Rat
1581544Rf52Renal function QTL 520.05urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)1232156370259647894Rat
631669Iddm9Insulin dependent diabetes mellitus QTL 92.80.039blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1233190394258625266Rat
631536Lnnr2Liver neoplastic nodule remodeling QTL 22.90.0005liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)1233948574260522016Rat
631690Scl5Serum cholesterol level QTL 52.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1236125214260522016Rat
631836Stl31Serum triglyceride level QTL 314.640.00000487blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1237147813260522016Rat
631837Niddm35Non-insulin dependent diabetes mellitus QTL 350.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1238699859259647894Rat

Markers in Region
RH80285  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21243,695,192 - 243,695,410 (+)MAPPERmRatBN7.2
Rnor_6.01264,583,201 - 264,583,418NCBIRnor6.0
Rnor_5.01272,025,642 - 272,025,859UniSTSRnor5.0
RGSC_v3.41249,895,178 - 249,895,395UniSTSRGSC3.4
Celera1239,506,637 - 239,506,854UniSTS
Cytogenetic Map1q54UniSTS
PMC19453P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21243,649,921 - 243,650,009 (+)MAPPERmRatBN7.2
Rnor_6.01264,537,908 - 264,537,995NCBIRnor6.0
Rnor_5.01271,980,418 - 271,980,505UniSTSRnor5.0
RGSC_v3.41249,849,452 - 249,849,539UniSTSRGSC3.4
Celera1239,461,455 - 239,461,542UniSTS
Cytogenetic Map1q54UniSTS
D11Bir2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.237,207,455 - 7,207,593 (+)MAPPERmRatBN7.2
mRatBN7.21243,621,084 - 243,621,222 (+)MAPPERmRatBN7.2
Rnor_6.01264,508,928 - 264,509,065NCBIRnor6.0
Rnor_6.031,549,052 - 1,549,189NCBIRnor6.0
Rnor_5.031,541,880 - 1,542,017UniSTSRnor5.0
Rnor_5.01271,951,604 - 271,951,741UniSTSRnor5.0
RGSC_v3.41249,808,393 - 249,808,530UniSTSRGSC3.4
RGSC_v3.432,693,184 - 2,693,321UniSTSRGSC3.4
Celera32,044,635 - 2,044,772UniSTS
Celera1239,432,502 - 239,432,639UniSTS
Cytogenetic Map3p13UniSTS
Cytogenetic Map1q54UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system exocrine system hemolymphoid system hepatobiliary system musculoskeletal system nervous system renal system reproductive system
High
Medium 5 29 10
Low 34 6 22
Below cutoff 9 7 2 7 1 21 3

Sequence


RefSeq Acc Id: ENSRNOT00000050076   ⟹   ENSRNOP00000040130
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1243,616,745 - 243,695,321 (+)Ensembl
Rnor_6.0 Ensembl1264,504,591 - 264,583,329 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000085811   ⟹   ENSRNOP00000070907
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1243,616,606 - 243,695,321 (+)Ensembl
Rnor_6.0 Ensembl1264,507,985 - 264,538,070 (+)Ensembl
RefSeq Acc Id: NM_001106361   ⟹   NP_001099831
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81253,565,922 - 253,644,490 (+)NCBI
mRatBN7.21243,616,745 - 243,695,321 (+)NCBI
Rnor_6.01264,504,591 - 264,583,329 (+)NCBI
Rnor_5.01271,936,269 - 272,027,514 (+)NCBI
RGSC_v3.41249,804,055 - 249,895,306 (+)RGD
Celera1239,428,164 - 239,506,765 (+)RGD
Sequence:
RefSeq Acc Id: XM_006231443   ⟹   XP_006231505
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81253,565,686 - 253,646,623 (+)NCBI
mRatBN7.21243,616,509 - 243,697,454 (+)NCBI
Rnor_6.01264,493,579 - 264,585,073 (+)NCBI
Rnor_5.01271,936,269 - 272,027,514 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039109033   ⟹   XP_038964961
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81253,565,263 - 253,646,623 (+)NCBI
mRatBN7.21243,616,645 - 243,697,454 (+)NCBI
RefSeq Acc Id: XM_039109034   ⟹   XP_038964962
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81253,565,822 - 253,646,623 (+)NCBI
mRatBN7.21243,616,645 - 243,697,454 (+)NCBI
RefSeq Acc Id: XM_039109046   ⟹   XP_038964974
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81253,565,686 - 253,646,623 (+)NCBI
mRatBN7.21243,616,509 - 243,697,454 (+)NCBI
RefSeq Acc Id: XM_063287134   ⟹   XP_063143204
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81253,555,447 - 253,646,623 (+)NCBI
RefSeq Acc Id: XM_063287138   ⟹   XP_063143208
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81253,565,822 - 253,646,623 (+)NCBI
RefSeq Acc Id: NP_001099831   ⟸   NM_001106361
- UniProtKB: D4ACZ2 (UniProtKB/TrEMBL),   A6JHG7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006231505   ⟸   XM_006231443
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: ENSRNOP00000070907   ⟸   ENSRNOT00000085811
RefSeq Acc Id: ENSRNOP00000040130   ⟸   ENSRNOT00000050076
RefSeq Acc Id: XP_038964974   ⟸   XM_039109046
- Peptide Label: isoform X6
RefSeq Acc Id: XP_038964962   ⟸   XM_039109034
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038964961   ⟸   XM_039109033
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063143204   ⟸   XM_063287134
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063143208   ⟸   XM_063287138
- Peptide Label: isoform X2
Protein Domains
Paired

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4ACZ2-F1-model_v2 AlphaFold D4ACZ2 1-416 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305568 AgrOrtholog
BioCyc Gene G2FUF-55580 BioCyc
Ensembl Genes ENSRNOG00000014253 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000050076 ENTREZGENE
  ENSRNOT00000050076.5 UniProtKB/TrEMBL
  ENSRNOT00000085811.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.10 UniProtKB/TrEMBL
InterPro Homeodomain-like UniProtKB/TrEMBL
  Paired_box_N UniProtKB/TrEMBL
  PAIRED_DNA_bd_dom UniProtKB/TrEMBL
  Pax2_C UniProtKB/TrEMBL
  PAX_fam UniProtKB/TrEMBL
  WH-like_DNA-bd_sf UniProtKB/TrEMBL
KEGG Report rno:293992 UniProtKB/TrEMBL
NCBI Gene 293992 ENTREZGENE
PANTHER PAIRED BOX PROTEIN PAX-2 UniProtKB/TrEMBL
  PTHR45636 UniProtKB/TrEMBL
Pfam PAX UniProtKB/TrEMBL
  Pax2_C UniProtKB/TrEMBL
PharmGKB PAX2 RGD
PhenoGen Pax2 PhenoGen
PRINTS PAIREDBOX UniProtKB/TrEMBL
PROSITE PAIRED_1 UniProtKB/TrEMBL
  PAIRED_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000014253 RatGTEx
SMART PAX UniProtKB/TrEMBL
Superfamily-SCOP Homeodomain_like UniProtKB/TrEMBL
UniProt A0A0G2JZ47_RAT UniProtKB/TrEMBL
  A6JHG7 ENTREZGENE, UniProtKB/TrEMBL
  D4ACZ2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-10-30 Pax2  paired box 2  Pax2  paired box gene 2   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Pax2  paired box gene 2   Pax2_predicted  paired box gene 2 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Pax2_predicted  paired box gene 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED