Pax2 (paired box 2) - Rat Genome Database

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Gene: Pax2 (paired box 2) Rattus norvegicus
Analyze
Symbol: Pax2
Name: paired box 2
RGD ID: 1305568
Description: Predicted to have several functions, including C2H2 zinc finger domain binding activity; DNA-binding transcription factor activity, RNA polymerase II-specific; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including aging; cellular response to epidermal growth factor stimulus; and positive regulation of cell population proliferation. Localizes to lysosome and nucleus. Biomarker of nephroblastoma. Human ortholog(s) of this gene implicated in focal segmental glomerulosclerosis 7 and renal coloboma syndrome. Orthologous to human PAX2 (paired box 2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; atrazine; bis(2-ethylhexyl) phthalate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: LOC293992; paired box gene 2; paired box homeotic gene 2; paired box protein 2; paired box protein Pax-2; Pax-2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21243,616,509 - 243,697,454 (+)NCBI
Rnor_6.0 Ensembl1264,504,591 - 264,583,329 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01264,493,579 - 264,585,073 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01271,936,269 - 272,027,514 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41249,804,055 - 249,895,306 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11250,026,899 - 250,155,758 (+)NCBI
Celera1239,428,164 - 239,506,765 (+)NCBICelera
Cytogenetic Map1q54NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aging  (IEP)
anatomical structure development  (IBA)
brain morphogenesis  (ISO,ISS)
branching involved in ureteric bud morphogenesis  (ISO,ISS)
camera-type eye development  (ISO,ISS)
cell fate determination  (ISO,ISS)
cellular response to epidermal growth factor stimulus  (IEP)
cellular response to glucose stimulus  (ISO,ISS)
cellular response to hydrogen peroxide  (ISO,ISS)
cellular response to mechanical stimulus  (ISO)
cellular response to retinoic acid  (ISO,ISS)
central nervous system development  (ISO)
cochlea development  (ISO,ISS)
cochlea morphogenesis  (ISO,ISS)
glial cell differentiation  (ISO,ISS)
inner ear morphogenesis  (ISO,ISS)
kidney development  (ISO)
mesenchymal to epithelial transition  (ISO,ISS)
mesenchymal to epithelial transition involved in metanephros morphogenesis  (ISO,ISS)
mesodermal cell fate specification  (ISO,ISS)
mesonephric duct development  (ISO)
mesonephric tubule development  (ISO)
mesonephric tubule formation  (ISO)
mesonephros development  (ISO,ISS)
metanephric collecting duct development  (ISO,ISS)
metanephric distal convoluted tubule development  (ISO,ISS)
metanephric epithelium development  (ISO)
metanephric mesenchymal cell differentiation  (ISO,ISS)
metanephric mesenchyme development  (ISO,ISS)
metanephric nephron tubule formation  (ISO,ISS)
metanephros development  (ISO)
negative regulation of apoptotic process  (ISO,ISS)
negative regulation of apoptotic process involved in metanephric collecting duct development  (ISO,ISS)
negative regulation of apoptotic process involved in metanephric nephron tubule development  (ISO,ISS)
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  (ISO,ISS)
negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis  (ISO,ISS)
negative regulation of mesenchymal cell apoptotic process involved in metanephros development  (ISO,ISS)
negative regulation of programmed cell death  (ISO,ISS)
negative regulation of reactive oxygen species metabolic process  (ISO,ISS)
negative regulation of transcription by RNA polymerase II  (ISO)
negative regulation of transcription, DNA-templated  (ISO,ISS)
nephric duct formation  (ISO,ISS)
neural tube closure  (ISO,ISS)
optic chiasma development  (ISO,ISS)
optic cup morphogenesis involved in camera-type eye development  (ISO,ISS)
optic nerve development  (ISO,ISS)
optic nerve morphogenesis  (ISO,ISS)
optic nerve structural organization  (ISO,ISS)
pancreas development  (ISO)
paramesonephric duct development  (ISO)
positive regulation of branching involved in ureteric bud morphogenesis  (ISO,ISS)
positive regulation of cell population proliferation  (IMP)
positive regulation of epithelial cell proliferation  (ISO)
positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis  (ISO,ISS)
positive regulation of metanephric DCT cell differentiation  (ISO,ISS)
positive regulation of metanephric glomerulus development  (ISO,ISS)
positive regulation of optic nerve formation  (ISO,ISS)
positive regulation of transcription by RNA polymerase II  (ISO,ISS)
positive regulation of transcription, DNA-templated  (ISO,ISS)
pronephric field specification  (ISO,ISS)
pronephros development  (ISO,ISS)
protein kinase B signaling  (ISO,ISS)
reactive oxygen species metabolic process  (ISO,ISS)
regulation of apoptotic process  (ISO)
regulation of metanephric nephron tubule epithelial cell differentiation  (ISO,ISS)
regulation of metanephros size  (ISO,ISS)
regulation of programmed cell death  (ISO)
regulation of transcription by RNA polymerase II  (IBA)
response to nutrient levels  (IEP)
retinal pigment epithelium development  (ISO,ISS)
stem cell differentiation  (ISO,ISS)
ureter development  (ISO,ISS)
ureter maturation  (ISO,ISS)
ureter morphogenesis  (ISO)
ureteric bud development  (ISO)
urogenital system development  (ISO,ISS)
vestibulocochlear nerve formation  (ISO,ISS)

Cellular Component

References

Additional References at PubMed
PMID:1337742   PMID:1723950   PMID:7720589   PMID:7856737   PMID:8413205   PMID:8575306   PMID:8951055   PMID:9178767   PMID:10322633   PMID:10536059   PMID:10980123   PMID:11731455  
PMID:11940591   PMID:12200151   PMID:12435636   PMID:12756174   PMID:14695376   PMID:15153556   PMID:15242798   PMID:15905411   PMID:16018995   PMID:16319112   PMID:16368682   PMID:16672320  
PMID:16735463   PMID:16916509   PMID:17047028   PMID:17164400   PMID:17166926   PMID:17300925   PMID:17314325   PMID:17357786   PMID:17513325   PMID:17538188   PMID:17785448   PMID:17881463  
PMID:18000879   PMID:18083586   PMID:18607644   PMID:19037705   PMID:19048125   PMID:19118900   PMID:20171952   PMID:20486844   PMID:20727173   PMID:21731775   PMID:21778682   PMID:23107969  
PMID:23503776   PMID:24471428   PMID:24676634   PMID:24710423   PMID:27939388   PMID:29280536   PMID:30117015  


Genomics

Comparative Map Data
Pax2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21243,616,509 - 243,697,454 (+)NCBI
Rnor_6.0 Ensembl1264,504,591 - 264,583,329 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01264,493,579 - 264,585,073 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01271,936,269 - 272,027,514 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41249,804,055 - 249,895,306 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11250,026,899 - 250,155,758 (+)NCBI
Celera1239,428,164 - 239,506,765 (+)NCBICelera
Cytogenetic Map1q54NCBI
PAX2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl10100,735,603 - 100,829,944 (+)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl10100,735,603 - 100,829,941 (+)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl10100,735,396 - 100,829,944 (+)EnsemblGRCh38hg38GRCh38
GRCh3810100,735,396 - 100,829,944 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3710102,495,153 - 102,589,701 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3610102,495,458 - 102,579,688 (+)NCBINCBI36hg18NCBI36
Build 3410102,495,321 - 102,579,687NCBI
Celera1096,243,249 - 96,327,456 (+)NCBI
Cytogenetic Map10q24.31NCBI
HuRef1096,133,870 - 96,218,089 (+)NCBIHuRef
CHM1_110102,779,745 - 102,873,990 (+)NCBICHM1_1
Pax2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391944,735,040 - 44,826,708 (+)NCBIGRCm39mm39
GRCm39 Ensembl1944,744,484 - 44,826,310 (+)Ensembl
GRCm381944,746,601 - 44,838,269 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1944,756,045 - 44,837,871 (+)EnsemblGRCm38mm10GRCm38
MGSCv371944,831,884 - 44,910,517 (+)NCBIGRCm37mm9NCBIm37
MGSCv361944,810,705 - 44,889,338 (+)NCBImm8
Celera1945,528,146 - 45,605,640 (+)NCBICelera
Cytogenetic Map19C3NCBI
cM Map1938.09NCBI
Pax2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554859,350,087 - 9,430,607 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554859,351,913 - 9,430,607 (-)NCBIChiLan1.0ChiLan1.0
PAX2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.110100,822,676 - 100,904,065 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl10100,822,676 - 100,904,028 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01097,344,978 - 97,429,086 (+)NCBIMhudiblu_PPA_v0panPan3
PAX2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12813,442,894 - 13,519,853 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2813,442,893 - 13,532,094 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2813,606,001 - 13,692,205 (+)NCBI
ROS_Cfam_1.02813,904,432 - 13,990,703 (+)NCBI
UMICH_Zoey_3.12813,450,612 - 13,536,833 (+)NCBI
UNSW_CanFamBas_1.02813,492,258 - 13,578,015 (+)NCBI
UU_Cfam_GSD_1.02813,623,521 - 13,709,771 (+)NCBI
Pax2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721333,215,941 - 33,325,282 (-)NCBI
SpeTri2.0NW_0049366004,850,594 - 4,939,010 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PAX2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14111,834,168 - 111,914,304 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114111,822,334 - 111,914,950 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214121,481,577 - 121,574,679 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103216393
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1993,763,975 - 93,847,180 (+)NCBI
Pax2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624831375,851 - 453,968 (+)NCBI

Position Markers
RH80285  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01264,583,201 - 264,583,418NCBIRnor6.0
Rnor_5.01272,025,642 - 272,025,859UniSTSRnor5.0
RGSC_v3.41249,895,178 - 249,895,395UniSTSRGSC3.4
Celera1239,506,637 - 239,506,854UniSTS
Cytogenetic Map1q54UniSTS
PMC19453P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01264,537,908 - 264,537,995NCBIRnor6.0
Rnor_5.01271,980,418 - 271,980,505UniSTSRnor5.0
RGSC_v3.41249,849,452 - 249,849,539UniSTSRGSC3.4
Celera1239,461,455 - 239,461,542UniSTS
Cytogenetic Map1q54UniSTS
D11Bir2  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.031,549,052 - 1,549,189NCBIRnor6.0
Rnor_6.01264,508,928 - 264,509,065NCBIRnor6.0
Rnor_5.031,541,880 - 1,542,017UniSTSRnor5.0
Rnor_5.01271,951,604 - 271,951,741UniSTSRnor5.0
RGSC_v3.432,693,184 - 2,693,321UniSTSRGSC3.4
RGSC_v3.41249,808,393 - 249,808,530UniSTSRGSC3.4
Celera32,044,635 - 2,044,772UniSTS
Celera1239,432,502 - 239,432,639UniSTS
Cytogenetic Map3p13UniSTS
Cytogenetic Map1q54UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2292216Bw80Body weight QTL 803.230.0019body mass (VT:0001259)body weight (CMO:0000012)1233490105264802994Rat
70211Niddm24Non-insulin dependent diabetes mellitus QTL 243.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1236795785281795785Rat
631215Stl8Serum triglyceride level QTL 89.270.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1245529606282763074Rat
2302040Pia35Pristane induced arthritis QTL 353.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1236265430281265430Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1156446196274977688Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1161321152273792054Rat
724533Rf51Renal function QTL 515.30.0002kidney plasma flow trait (VT:0005524)renal plasma flow (CMO:0001914)1238830534278228767Rat
724538Kidm1Kidney mass QTL 13.2kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1233663100273792054Rat
724552Glom2Glomerulus QTL 23.30.0001kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)1243272341282763074Rat
734767Niddm57Non-insulin dependent diabetes mellitus QTL 57body mass (VT:0001259)body weight (CMO:0000012)1244401175282365384Rat
734768Niddm59Non-insulin dependent diabetes mellitus QTL 59body mass (VT:0001259)body weight (CMO:0000012)1235850810280850810Rat
734769Niddm58Non-insulin dependent diabetes mellitus QTL 58body mass (VT:0001259)body weight (CMO:0000012)1244992467282365384Rat
631669Iddm9Insulin dependent diabetes mellitus QTL 92.80.039blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1252955158280632620Rat
631690Scl5Serum cholesterol level QTL 52.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1258132568282763074Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1167394665278228889Rat
1581544Rf52Renal function QTL 520.05total urine protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)1252948438281795785Rat
731175Uae20Urinary albumin excretion QTL 203.50.0018urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1241482188281795785Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1191825895279986079Rat
631536Lnnr2Liver neoplastic nodule remodeling QTL 22.90.0005liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)1255728828282763074Rat
1598821Rf55Renal function QTL 556.3renal blood flow trait (VT:2000006)ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)1238824734279986079Rat
2300175Bmd40Bone mineral density QTL 4015.40.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)1221901238266901238Rat
2293655Bss36Bone structure and strength QTL 3610.660.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1221901238266901238Rat
2293674Bss39Bone structure and strength QTL 397.10.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)1221901238266901238Rat
2293694Bss38Bone structure and strength QTL 387.050.0001femur strength trait (VT:0010010)femur stiffness (CMO:0001674)1221901238266901238Rat
2293700Bmd27Bone mineral density QTL 276.60.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1244401175264636028Rat
2293701Bmd34Bone mineral density QTL 348.30.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)1244401175264636028Rat
631836Stl31Serum triglyceride level QTL 314.640.00000487blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1259295704282763074Rat
631837Niddm35Non-insulin dependent diabetes mellitus QTL 350.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1258709726281795785Rat
631843Bw116Body weight QTL 1164.10.016abdominal adipose amount (VT:1000220)abdominal fat pad weight (CMO:0000088)1244401175282365384Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1217054291281795785Rat
1357399Bw45Body weight QTL 453.05body mass (VT:0001259)body mass index (BMI) (CMO:0000105)1225689973270689973Rat
1357404Bw42Body weight QTL 424.490.0001body mass (VT:0001259)body weight (CMO:0000012)1225689973270689973Rat
1600363Hc6Hypercalciuria QTL 62.7urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1195598053265002735Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1213476630278978026Rat
1600392Bw123Body weight QTL 1230.001body mass (VT:0001259)body weight (CMO:0000012)1244087148282763074Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1213476630278978026Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1213476630278978026Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1226706329271706329Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1161321256273791893Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1196395041282763074Rat
1578778Pur4Proteinuria QTL 43.30.003total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1161321256273791893Rat
1300108Rf8Renal function QTL 83.75renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)1249206242281795785Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1161784169278228889Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1192639698278228889Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1161784169278228889Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1192639698278228889Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1161784169278228889Rat
1549910Bw54Body weight QTL 540.05body mass (VT:0001259)body weight (CMO:0000012)1236795785281795785Rat
2316896Gluco57Glucose level QTL 577.2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1249607907266793958Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1163796316282763074Rat
1358191Ept10Estrogen-induced pituitary tumorigenesis QTL 103.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)1210360774264802828Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1174905700264802994Rat
1358890Bp259Blood pressure QTL 2593.06arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1230420627282645769Rat
1358898Bp255Blood pressure QTL 2553.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1208517798266948272Rat
61327Eae7Experimental allergic encephalomyelitis QTL 75.6body mass (VT:0001259)change in body weight (CMO:0002045)1236265430281265430Rat
61400Niddm1Non-insulin dependent diabetes mellitus QTL 111blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1238830408266793958Rat
8655655Arrd2Age-related retinal degeneration QTL 27.79retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1202571665264802994Rat
7394701Uae46Urinary albumin excretion QTL 463.60.0056urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1221901238266901238Rat
7387289Uae45Urinary albumin excretion QTL 452.860.0021urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1244148899282763074Rat
8655855Arrd3Age-related retinal degeneration QTL 33.07lens clarity trait (VT:0001304)cataract incidence/prevalence measurement (CMO:0001585)1202571665264802994Rat
10053715Scort24Serum corticosterone level QTL 242.130.0088blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1242302911282763074Rat
10059587Bw173Body weight QTL 1733.230.025body mass (VT:0001259)body weight (CMO:0000012)1222492538267492538Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:70
Count of miRNA genes:65
Interacting mature miRNAs:69
Transcripts:ENSRNOT00000050076
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system exocrine system hemolymphoid system hepatobiliary system musculoskeletal system nervous system renal system reproductive system
High
Medium 5 29 10
Low 34 6 22
Below cutoff 9 7 2 7 1 21 3

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000050076   ⟹   ENSRNOP00000040130
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1264,504,591 - 264,583,329 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000085811   ⟹   ENSRNOP00000070907
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1264,507,985 - 264,538,070 (+)Ensembl
RefSeq Acc Id: NM_001106361   ⟹   NP_001099831
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21243,616,745 - 243,695,321 (+)NCBI
Rnor_6.01264,504,591 - 264,583,329 (+)NCBI
Rnor_5.01271,936,269 - 272,027,514 (+)NCBI
RGSC_v3.41249,804,055 - 249,895,306 (+)RGD
Celera1239,428,164 - 239,506,765 (+)RGD
Sequence:
RefSeq Acc Id: XM_006231443   ⟹   XP_006231505
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21243,616,509 - 243,697,454 (+)NCBI
Rnor_6.01264,493,579 - 264,585,073 (+)NCBI
Rnor_5.01271,936,269 - 272,027,514 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008760404   ⟹   XP_008758626
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01264,493,579 - 264,583,222 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039109033   ⟹   XP_038964961
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21243,616,645 - 243,697,454 (+)NCBI
RefSeq Acc Id: XM_039109034   ⟹   XP_038964962
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21243,616,645 - 243,697,454 (+)NCBI
RefSeq Acc Id: XM_039109038   ⟹   XP_038964966
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21243,616,645 - 243,697,454 (+)NCBI
RefSeq Acc Id: XM_039109041   ⟹   XP_038964969
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21243,616,645 - 243,697,454 (+)NCBI
RefSeq Acc Id: XM_039109046   ⟹   XP_038964974
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21243,616,509 - 243,697,454 (+)NCBI
RefSeq Acc Id: XM_039109049   ⟹   XP_038964977
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21243,616,509 - 243,697,454 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_001099831   ⟸   NM_001106361
- UniProtKB: D4ACZ2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006231505   ⟸   XM_006231443
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_008758626   ⟸   XM_008760404
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000070907   ⟸   ENSRNOT00000085811
RefSeq Acc Id: ENSRNOP00000040130   ⟸   ENSRNOT00000050076
RefSeq Acc Id: XP_038964977   ⟸   XM_039109049
- Peptide Label: isoform X7
RefSeq Acc Id: XP_038964974   ⟸   XM_039109046
- Peptide Label: isoform X6
RefSeq Acc Id: XP_038964962   ⟸   XM_039109034
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038964969   ⟸   XM_039109041
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038964961   ⟸   XM_039109033
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038964966   ⟸   XM_039109038
- Peptide Label: isoform X3
Protein Domains
Paired

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Damaging Variants


Assembly: RGSC_v3.4

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
1 249807700 249807701 A G snv HCR/2Mco (UMich)


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305568 AgrOrtholog
Ensembl Genes ENSRNOG00000014253 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000040130 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000070907 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000050076 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000085811 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.10 UniProtKB/TrEMBL
InterPro Homeodomain-like UniProtKB/TrEMBL
  Paired_box_N UniProtKB/TrEMBL
  PAIRED_DNA_bd_dom UniProtKB/TrEMBL
  Pax2_C UniProtKB/TrEMBL
  PAX_fam UniProtKB/TrEMBL
  WH-like_DNA-bd_sf UniProtKB/TrEMBL
KEGG Report rno:293992 UniProtKB/TrEMBL
NCBI Gene 293992 ENTREZGENE
PANTHER PTHR45636 UniProtKB/TrEMBL
Pfam PAX UniProtKB/TrEMBL
  Pax2_C UniProtKB/TrEMBL
PharmGKB PAX2 RGD
PhenoGen Pax2 PhenoGen
PRINTS PAIREDBOX UniProtKB/TrEMBL
PROSITE PAIRED_1 UniProtKB/TrEMBL
  PAIRED_2 UniProtKB/TrEMBL
SMART PAX UniProtKB/TrEMBL
Superfamily-SCOP Homeodomain_like UniProtKB/TrEMBL
UniProt A0A0G2JZ47_RAT UniProtKB/TrEMBL
  D4ACZ2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-10-30 Pax2  paired box 2  Pax2  paired box gene 2   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Pax2  paired box gene 2   Pax2_predicted  paired box gene 2 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Pax2_predicted  paired box gene 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED