Fgf8 (fibroblast growth factor 8) - Rat Genome Database

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Gene: Fgf8 (fibroblast growth factor 8) Rattus norvegicus
Analyze
Symbol: Fgf8
Name: fibroblast growth factor 8
RGD ID: 70891
Description: Enables chemoattractant activity. Involved in several processes, including neuron development; response to oxidative stress; and response to xenobiotic stimulus. Located in external side of plasma membrane. Biomarker of hypospadias. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 6 with or without anosmia and prostate carcinoma in situ. Orthologous to human FGF8 (fibroblast growth factor 8); PARTICIPATES IN fibroblast growth factor signaling pathway; melanoma pathway; mitogen activated protein kinase signaling pathway; INTERACTS WITH bisphenol A; busulfan; dibutyl phthalate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Fgf6c; fibroblast growth factor 6c; fibroblast growth factor 8 (androgen-induced)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21244,584,477 - 244,590,359 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1244,584,652 - 244,590,359 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1252,726,050 - 252,731,769 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01259,424,173 - 259,429,872 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01252,076,241 - 252,081,969 (-)NCBIRnor_WKY
Rnor_6.01265,492,949 - 265,498,965 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1265,493,124 - 265,498,831 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01272,923,589 - 272,929,296 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41250,951,023 - 250,956,730 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11251,211,591 - 251,217,299 (-)NCBI
Celera1240,393,901 - 240,399,608 (-)NCBICelera
Cytogenetic Map1q54NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aorta morphogenesis  (ISO)
apoptotic process  (ISO)
blood vessel remodeling  (ISO)
bone development  (ISO)
branching involved in blood vessel morphogenesis  (ISO)
branching involved in salivary gland morphogenesis  (ISO)
branching involved in ureteric bud morphogenesis  (ISO)
cell fate commitment  (ISO)
cell migration involved in mesendoderm migration  (ISO)
cell population proliferation  (ISO)
cell proliferation in forebrain  (ISO)
central nervous system neuron development  (IMP)
corticotropin hormone secreting cell differentiation  (ISO)
determination of left/right symmetry  (ISO)
dopaminergic neuron differentiation  (ISO)
dorsal/ventral axon guidance  (IMP)
dorsal/ventral pattern formation  (IBA)
embryo development ending in birth or egg hatching  (ISO)
embryonic heart tube development  (IBA,ISO)
embryonic hindlimb morphogenesis  (ISO)
embryonic neurocranium morphogenesis  (ISO)
epithelial to mesenchymal transition involved in endocardial cushion formation  (ISO)
fibroblast growth factor receptor signaling pathway  (IBA,ISO)
forebrain dorsal/ventral pattern formation  (ISO)
forebrain morphogenesis  (ISO)
forebrain neuron development  (IMP)
generation of neurons  (ISO)
gonad development  (ISO)
heart development  (ISO)
heart looping  (ISO)
heart morphogenesis  (IBA,ISO)
inner ear morphogenesis  (ISO)
kidney development  (ISO)
larynx morphogenesis  (ISO)
limb morphogenesis  (IBA,ISO)
lung development  (ISO)
lung morphogenesis  (ISO)
male genitalia development  (ISO)
MAPK cascade  (ISO)
mesodermal cell migration  (ISO)
mesonephros development  (ISO)
metanephros development  (ISO)
midbrain-hindbrain boundary development  (ISO)
mitotic nuclear division  (ISO)
motor neuron axon guidance  (IMP)
negative regulation of apoptotic process  (ISO)
negative regulation of cardiac muscle tissue development  (ISO)
negative regulation of neuron apoptotic process  (ISO)
neural plate morphogenesis  (ISO)
neuroepithelial cell differentiation  (ISO)
neuron apoptotic process  (ISO)
neuron differentiation  (IBA)
odontogenesis  (ISO)
organ growth  (ISO)
organ induction  (ISO)
otic vesicle formation  (ISO)
outflow tract morphogenesis  (ISO)
outflow tract septum morphogenesis  (ISO)
pallium development  (ISO)
pharyngeal system development  (ISO)
positive chemotaxis  (IEA)
positive regulation of cell population proliferation  (IBA,ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of G protein-coupled receptor signaling pathway  (ISO)
positive regulation of gene expression  (IBA,ISO)
positive regulation of mitotic nuclear division  (ISO)
positive regulation of organ growth  (ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of protein phosphorylation  (IBA)
positive regulation of stem cell proliferation  (ISO)
regulation of cell migration  (IBA)
regulation of odontogenesis of dentin-containing tooth  (ISO)
response to organic cyclic compound  (IEP)
response to oxidative stress  (IDA)
response to xenobiotic stimulus  (IEP)
signal transduction involved in regulation of gene expression  (ISO)
stem cell proliferation  (ISO)
subpallium development  (ISO)
telencephalon development  (ISO)
thyroid gland development  (ISO)
thyroid-stimulating hormone-secreting cell differentiation  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. MMTV-Fgf8 transgenic mice develop mammary and salivary gland neoplasia and ovarian stromal hyperplasia. Daphna-Iken D, etal., Oncogene. 1998 Nov 26;17(21):2711-7.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. FGF8 isoform b expression in human prostate cancer. Gnanapragasam VJ, etal., Br J Cancer. 2003 May 6;88(9):1432-8.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Establishing the trochlear motor axon trajectory: role of the isthmic organiser and Fgf8. Irving C, etal., Development. 2002 Dec;129(23):5389-98.
6. Dual odontogenic origins develop at the early stage of rat maxillary incisor development. Kriangkrai R, etal., Anat Embryol (Berl). 2006 Mar;211(2):101-8. Epub 2006 Jan 17.
7. Fibroblast growth factor-8 protects cultured rat hippocampal neurons from oxidative insult. Mark RJ, etal., Brain Res 1999 May 29;830(1):88-93.
8. Increased expression of fibroblast growth factor 8 in human breast cancer. Marsh SK, etal., Oncogene. 1999 Jan 28;18(4):1053-60.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
12. Developmental abnormalities in rat embryos leading to tibial ray deficiencies induced by busulfan. Otsuji M, etal., Birth Defects Res A Clin Mol Teratol. 2005 Jun;73(6):461-7.
13. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
14. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
15. GOA pipeline RGD automated data pipeline
16. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. A splice variant of CD44 expressed in the apical ectodermal ridge presents fibroblast growth factors to limb mesenchyme and is required for limb outgrowth. Sherman L, etal., Genes Dev. 1998 Apr 1;12(7):1058-71.
19. Fibroblast growth factor 8 isoform B overexpression in prostate epithelium: a new mouse model for prostatic intraepithelial neoplasia. Song Z, etal., Cancer Res. 2002 Sep 1;62(17):5096-105.
20. Predominant expression of fibroblast growth factor (FGF) 8, FGF4, and FGF receptor 1 in nonseminomatous and highly proliferative components of testicular germ cell tumors. Suzuki K, etal., Virchows Arch. 2001 Nov;439(5):616-21.
21. Role of fibroblast growth factor 8 (FGF8) in animal models of osteoarthritis. Uchii M, etal., Arthritis Res Ther. 2008;10(4):R90. Epub 2008 Aug 12.
22. Expression of fibroblast growth factor (FGF)-8 isoforms and FGF receptors in human ovarian tumors. Valve E, etal., Int J Cancer. 2000 Dec 1;88(5):718-25.
23. Increased expression of FGF-8 isoforms and FGF receptors in human premalignant prostatic intraepithelial neoplasia lesions and prostate cancer. Valve EM, etal., Lab Invest. 2001 Jun;81(6):815-26.
24. Correlation between androgen receptor expression and FGF8 mRNA levels in patients with prostate cancer and benign prostatic hypertrophy. Wang Q, etal., J Clin Pathol. 1999 Jan;52(1):29-34.
25. FGF and Shh signals control dopaminergic and serotonergic cell fate in the anterior neural plate. Ye W, etal., Cell. 1998 May 29;93(5):755-66.
26. Molecular and toxicologic research in newborn hypospadiac male rats following in utero exposure to di-n-butyl phthalate (DBP). Zhu YJ, etal., Toxicology. 2009 Jun 16;260(1-3):120-5. Epub 2009 Apr 5.
Additional References at PubMed
PMID:8663044   PMID:8891346   PMID:9244299   PMID:9435295   PMID:9463347   PMID:9847236   PMID:10381577   PMID:10411502   PMID:10421635   PMID:12783783   PMID:14623825   PMID:15042696  
PMID:15063181   PMID:15193287   PMID:15193767   PMID:15328019   PMID:15741321   PMID:15809037   PMID:15996652   PMID:16049111   PMID:16245339   PMID:16267092   PMID:16384934   PMID:16399079  
PMID:16613831   PMID:16696966   PMID:16720879   PMID:16720880   PMID:17000704   PMID:17265164   PMID:17309880   PMID:17360443   PMID:17394220   PMID:17601531   PMID:18437684   PMID:18462699  
PMID:18596921   PMID:19170063   PMID:19307307   PMID:19389367   PMID:19509466   PMID:20434519   PMID:20702560   PMID:20807544   PMID:21364285   PMID:22273727   PMID:24431450   PMID:27395007  
PMID:27804049   PMID:28177282   PMID:29626475  


Genomics

Comparative Map Data
Fgf8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21244,584,477 - 244,590,359 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1244,584,652 - 244,590,359 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1252,726,050 - 252,731,769 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01259,424,173 - 259,429,872 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01252,076,241 - 252,081,969 (-)NCBIRnor_WKY
Rnor_6.01265,492,949 - 265,498,965 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1265,493,124 - 265,498,831 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01272,923,589 - 272,929,296 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41250,951,023 - 250,956,730 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11251,211,591 - 251,217,299 (-)NCBI
Celera1240,393,901 - 240,399,608 (-)NCBICelera
Cytogenetic Map1q54NCBI
FGF8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810101,770,109 - 101,780,369 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl10101,770,109 - 101,780,371 (-)EnsemblGRCh38hg38GRCh38
GRCh3710103,529,866 - 103,540,126 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3610103,519,877 - 103,525,817 (-)NCBINCBI36Build 36hg18NCBI36
Build 3410103,519,876 - 103,525,817NCBI
Celera1097,268,628 - 97,274,500 (-)NCBICelera
Cytogenetic Map10q24.32NCBI
HuRef1097,160,317 - 97,170,664 (-)NCBIHuRef
CHM1_110103,813,541 - 103,823,715 (-)NCBICHM1_1
T2T-CHM13v2.010102,653,607 - 102,663,864 (-)NCBIT2T-CHM13v2.0
Fgf8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391945,724,930 - 45,731,380 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1945,725,237 - 45,731,354 (-)EnsemblGRCm39 Ensembl
GRCm381945,736,491 - 45,742,941 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1945,736,798 - 45,742,915 (-)EnsemblGRCm38mm10GRCm38
MGSCv371945,811,288 - 45,817,374 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361945,790,129 - 45,796,184 (-)NCBIMGSCv36mm8
Celera1946,499,127 - 46,505,223 (-)NCBICelera
Cytogenetic Map19C3NCBI
cM Map1938.75NCBI
Fgf8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554858,517,412 - 8,521,770 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554858,517,412 - 8,521,732 (+)NCBIChiLan1.0ChiLan1.0
FGF8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan110113,661,598 - 113,668,073 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01098,372,251 - 98,378,811 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.110101,844,792 - 101,849,873 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl10101,844,792 - 101,853,916 (-)Ensemblpanpan1.1panPan2
FGF8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12814,362,407 - 14,367,109 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2814,362,109 - 14,367,468 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2814,530,980 - 14,536,626 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02814,830,423 - 14,836,072 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2814,829,998 - 14,836,143 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12814,376,915 - 14,382,561 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02814,416,494 - 14,421,136 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02814,548,787 - 14,554,435 (-)NCBIUU_Cfam_GSD_1.0
Fgf8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721332,401,605 - 32,407,401 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366004,004,824 - 4,010,689 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049366004,004,847 - 4,010,626 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FGF8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14112,808,162 - 112,814,248 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114112,808,215 - 112,814,225 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214122,661,225 - 122,666,751 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FGF8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1994,797,157 - 94,803,725 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl994,798,088 - 94,803,629 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604855,874,226 - 55,880,198 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fgf8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248311,253,044 - 1,257,741 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248311,251,991 - 1,259,247 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Fgf8
9 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:183
Count of miRNA genes:148
Interacting mature miRNAs:155
Transcripts:ENSRNOT00000023558
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1150700142252085212Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1150700247252085048Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1156677124256448636Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1176426412257976495Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1177227632256448636Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1177227632256448636Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1179567751260522016Rat
1358898Bp255Blood pressure QTL 2553.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1191019702246062233Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1195804352257091168Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1199050459259647894Rat
2293694Bss38Bone structure and strength QTL 387.050.0001femur strength trait (VT:0010010)femur stiffness (CMO:0001674)1201554356246554356Rat
7394701Uae46Urinary albumin excretion QTL 463.60.0056urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1201554356246554356Rat
2300175Bmd40Bone mineral density QTL 4015.40.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)1201554356246554356Rat
2293655Bss36Bone structure and strength QTL 3610.660.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1201554356246554356Rat
2293674Bss39Bone structure and strength QTL 397.10.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)1201554356246554356Rat
10059587Bw173Body weight QTL 1733.230.025body mass (VT:0001259)body weight (CMO:0000012)1202069611247069611Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1206081677251081677Rat
1357399Bw45Body weight QTL 453.05body mass (VT:0001259)body mass index (BMI) (CMO:0000105)1206329708251329708Rat
1357404Bw42Body weight QTL 424.490.0001body mass (VT:0001259)body weight (CMO:0000012)1206329708251329708Rat
1358890Bp259Blood pressure QTL 2593.06arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1210702053260522016Rat
724538Kidm1Kidney mass QTL 13.2kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1213707201252085212Rat
734768Niddm59Non-insulin dependent diabetes mellitus QTL 59body mass (VT:0001259)body weight (CMO:0000012)1213843987258843987Rat
70211Niddm24Non-insulin dependent diabetes mellitus QTL 243.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1214647894259647894Rat
1549910Bw54Body weight QTL 540.05body mass (VT:0001259)body weight (CMO:0000012)1214647894259647894Rat
61327Eae7Experimental allergic encephalomyelitis QTL 75.6body mass (VT:0001259)change in body weight (CMO:0002045)1216255568260522016Rat
2302040Pia35Pristane induced arthritis QTL 353.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1216255568260522016Rat
1598821Rf55Renal function QTL 556.3renal blood flow trait (VT:2000006)ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)1218748008257976495Rat
61400Niddm1Non-insulin dependent diabetes mellitus QTL 111blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1218753689245907899Rat
724533Rf51Renal function QTL 515.30.0002kidney plasma flow trait (VT:0005524)renal plasma flow (CMO:0001914)1218753816256448513Rat
731175Uae20Urinary albumin excretion QTL 203.50.0018urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1221264111259647894Rat
10053715Scort24Serum corticosterone level QTL 242.130.0088blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1221414816260522016Rat
724552Glom2Glomerulus QTL 23.30.0001kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)1222363780260522016Rat
1600392Bw123Body weight QTL 1230.001body mass (VT:0001259)body weight (CMO:0000012)1223201027260522016Rat
734767Niddm57Non-insulin dependent diabetes mellitus QTL 57body mass (VT:0001259)body weight (CMO:0000012)1224054293260122809Rat
631843Bw116Body weight QTL 1164.10.016abdominal adipose amount (VT:1000220)abdominal fat pad weight (CMO:0000088)1224054293260122809Rat
734769Niddm58Non-insulin dependent diabetes mellitus QTL 58body mass (VT:0001259)body weight (CMO:0000012)1224569538260122809Rat
631215Stl8Serum triglyceride level QTL 89.270.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1225126575260522016Rat
1300108Rf8Renal function QTL 83.75renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)1228581588259647894Rat
2316896Gluco57Glucose level QTL 577.2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1228985440245907899Rat
1581544Rf52Renal function QTL 520.05urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)1232156370259647894Rat
631669Iddm9Insulin dependent diabetes mellitus QTL 92.80.039blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1233190394258625266Rat
631536Lnnr2Liver neoplastic nodule remodeling QTL 22.90.0005liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)1233948574260522016Rat
631690Scl5Serum cholesterol level QTL 52.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1236125214260522016Rat
631836Stl31Serum triglyceride level QTL 314.640.00000487blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1237147813260522016Rat
631837Niddm35Non-insulin dependent diabetes mellitus QTL 350.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1238699859259647894Rat

Markers in Region
D1Bda63  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21244,584,670 - 244,584,892 (+)MAPPERmRatBN7.2
Rnor_6.01265,493,143 - 265,493,364NCBIRnor6.0
Rnor_5.01272,923,608 - 272,923,829UniSTSRnor5.0
RGSC_v3.41250,951,042 - 250,951,263UniSTSRGSC3.4
Celera1240,393,920 - 240,394,141UniSTS
Cytogenetic Map1q54UniSTS
Fgf8  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21244,589,179 - 244,589,441 (+)MAPPERmRatBN7.2
Rnor_6.01265,497,652 - 265,497,913NCBIRnor6.0
Rnor_5.01272,928,117 - 272,928,378UniSTSRnor5.0
RGSC_v3.41250,955,551 - 250,955,812UniSTSRGSC3.4
Celera1240,398,429 - 240,398,690UniSTS
Cytogenetic Map1q54UniSTS
UniSTS:498236  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21244,584,536 - 244,584,913 (+)MAPPERmRatBN7.2
Rnor_6.01265,493,009 - 265,493,385NCBIRnor6.0
Rnor_5.01272,923,474 - 272,923,850UniSTSRnor5.0
RGSC_v3.41250,950,908 - 250,951,284UniSTSRGSC3.4
Celera1240,393,786 - 240,394,162UniSTS
Cytogenetic Map1q54UniSTS
UniSTS:547507  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21244,589,179 - 244,589,639 (+)MAPPERmRatBN7.2
Rnor_6.01265,497,652 - 265,498,111NCBIRnor6.0
Rnor_5.01272,928,117 - 272,928,576UniSTSRnor5.0
Celera1240,398,429 - 240,398,888UniSTS
Cytogenetic Map1q54UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system hemolymphoid system nervous system renal system reproductive system respiratory system
High
Medium 10 8 3
Low 12 6 6 21 10 21
Below cutoff 9 1 5 14 8 3

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000023558   ⟹   ENSRNOP00000023558
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1244,584,652 - 244,590,359 (-)Ensembl
Rnor_6.0 Ensembl1265,493,124 - 265,498,831 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000098455   ⟹   ENSRNOP00000097140
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1244,584,652 - 244,590,359 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000114421   ⟹   ENSRNOP00000078555
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1244,584,652 - 244,590,359 (-)Ensembl
RefSeq Acc Id: NM_133286   ⟹   NP_579820
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21244,584,652 - 244,590,359 (-)NCBI
Rnor_6.01265,493,124 - 265,498,831 (-)NCBI
Rnor_5.01272,923,589 - 272,929,296 (-)NCBI
RGSC_v3.41250,951,023 - 250,956,730 (-)RGD
Celera1240,393,901 - 240,399,608 (-)RGD
Sequence:
RefSeq Acc Id: XM_006231436   ⟹   XP_006231498
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21244,584,477 - 244,590,359 (-)NCBI
Rnor_6.01265,492,949 - 265,498,965 (-)NCBI
Rnor_5.01272,923,589 - 272,929,296 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006231437   ⟹   XP_006231499
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21244,584,477 - 244,590,359 (-)NCBI
Rnor_6.01265,492,949 - 265,498,965 (-)NCBI
Rnor_5.01272,923,589 - 272,929,296 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039107310   ⟹   XP_038963238
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21244,584,477 - 244,590,359 (-)NCBI
RefSeq Acc Id: XM_039107315   ⟹   XP_038963243
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21244,584,477 - 244,590,359 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_579820   ⟸   NM_133286
- Peptide Label: precursor
- UniProtKB: Q76LI5 (UniProtKB/TrEMBL),   D4A7C7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006231499   ⟸   XM_006231437
- Peptide Label: isoform X4
- UniProtKB: A0A8I5ZL19 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006231498   ⟸   XM_006231436
- Peptide Label: isoform X3
- UniProtKB: A0A8I6B5D5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000023558   ⟸   ENSRNOT00000023558
RefSeq Acc Id: XP_038963243   ⟸   XM_039107315
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038963238   ⟸   XM_039107310
- Peptide Label: isoform X1
RefSeq Acc Id: ENSRNOP00000078555   ⟸   ENSRNOT00000114421
RefSeq Acc Id: ENSRNOP00000097140   ⟸   ENSRNOT00000098455

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q76LI5-F1-model_v2 AlphaFold Q76LI5 1-204 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:70891 AgrOrtholog
BioCyc Gene G2FUF-55537 BioCyc
Ensembl Genes ENSRNOG00000017524 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000023558 ENTREZGENE
  ENSRNOP00000023558.4 UniProtKB/TrEMBL
  ENSRNOP00000078555 ENTREZGENE
  ENSRNOP00000078555.1 UniProtKB/TrEMBL
  ENSRNOP00000097140 ENTREZGENE
  ENSRNOP00000097140.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000023558 ENTREZGENE
  ENSRNOT00000023558.4 UniProtKB/TrEMBL
  ENSRNOT00000098455 ENTREZGENE
  ENSRNOT00000098455.1 UniProtKB/TrEMBL
  ENSRNOT00000114421 ENTREZGENE
  ENSRNOT00000114421.1 UniProtKB/TrEMBL
Gene3D-CATH 2.80.10.50 UniProtKB/TrEMBL
InterPro Cytokine_IL1-like UniProtKB/TrEMBL
  Fibroblast_GF_fam UniProtKB/TrEMBL
KEGG Report rno:29349 UniProtKB/TrEMBL
NCBI Gene 29349 ENTREZGENE
PANTHER PTHR11486 UniProtKB/TrEMBL
  PTHR11486:SF3 UniProtKB/TrEMBL
Pfam FGF UniProtKB/TrEMBL
PhenoGen Fgf8 PhenoGen
PRINTS IL1HBGF UniProtKB/TrEMBL
PROSITE HBGF_FGF UniProtKB/TrEMBL
SMART FGF UniProtKB/TrEMBL
Superfamily-SCOP Cytok_IL1_like UniProtKB/TrEMBL
UniProt A0A8I5ZL19 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6B5D5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8J8XTJ6_RAT UniProtKB/TrEMBL
  D4A7C7 ENTREZGENE
  Q76LI5 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary D4A7C7 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-07-09 Fgf8  fibroblast growth factor 8      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_product member of the FGF family 708333