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Gene: Afap1l2 (actin filament associated protein 1-like 2) Rattus norvegicus
Symbol: Afap1l2
Name: actin filament associated protein 1-like 2
Description: Predicted to have SH2 domain binding activity; SH3 domain binding activity; and protein tyrosine kinase activator activity. Predicted to be involved in several processes, including positive regulation of epidermal growth factor receptor signaling pathway; positive regulation of interleukin-8 production; and regulation of interleukin-6 production. Predicted to localize to the cytosol and plasma membrane. Orthologous to human AFAP1L2 (actin filament associated protein 1 like 2); INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 2,2',4,4'-Tetrabromodiphenyl ether; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: actin filament-associated protein 1-like 2; LOC292130; phosphatidylinositol 3-kinase-associated protein; RGD1310668; similar to expressed sequence AU041783
Homo sapiens (human) : AFAP1L2 (actin filament associated protein 1 like 2)  HGNC  Alliance
Mus musculus (house mouse) : Afap1l2 (actin filament associated protein 1-like 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Afap1l2 (actin filament associated protein 1 like 2)
Pan paniscus (bonobo/pygmy chimpanzee) : AFAP1L2 (actin filament associated protein 1 like 2)
Canis lupus familiaris (dog) : AFAP1L2 (actin filament associated protein 1 like 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Afap1l2 (actin filament associated protein 1 like 2)
Sus scrofa (pig) : AFAP1L2 (actin filament associated protein 1 like 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01277,730,760 - 277,827,299 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01285,110,704 - 285,206,347 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41263,220,056 - 263,256,132 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11263,431,340 - 263,470,406 (-)NCBI
Celera1251,661,305 - 251,756,440 (-)NCBICelera
Cytogenetic Map1q55NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
More on Afap1l2
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1310668
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.