Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes QTLs Strains Markers Genome Information Ontologies Cell Lines References FTP Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Variant Visualizer Multi-Ontology Enrichment (MOET) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) RatMine GViewer (Genome Viewer) Overgo Probe Designer ACP Haplotyper Genome Scanner
Aging & Age-Related Disease Cancer Cardiovascular Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Genetic Models PhenoMiner (Quantitative Phenotypes) Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Afap1l2 (actin filament associated protein 1-like 2) Rattus norvegicus
Analyze
Symbol: Afap1l2
Name: actin filament associated protein 1-like 2
Description: Predicted to have SH2 domain binding activity; SH3 domain binding activity; and protein tyrosine kinase activator activity. Predicted to be involved in several processes, including positive regulation of epidermal growth factor receptor signaling pathway; positive regulation of interleukin-8 production; and regulation of interleukin-6 production. Predicted to localize to the cytosol and plasma membrane. Orthologous to human AFAP1L2 (actin filament associated protein 1 like 2); INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 2,2',4,4'-Tetrabromodiphenyl ether; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: actin filament-associated protein 1-like 2; LOC292130; phosphatidylinositol 3-kinase-associated protein; RGD1310668; similar to expressed sequence AU041783
Orthologs:
Homo sapiens (human) : AFAP1L2 (actin filament associated protein 1 like 2)  HGNC  Alliance
Mus musculus (house mouse) : Afap1l2 (actin filament associated protein 1-like 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Afap1l2 (actin filament associated protein 1 like 2)
Pan paniscus (bonobo/pygmy chimpanzee) : AFAP1L2 (actin filament associated protein 1 like 2)
Canis lupus familiaris (dog) : AFAP1L2 (actin filament associated protein 1 like 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Afap1l2 (actin filament associated protein 1 like 2)
Sus scrofa (pig) : AFAP1L2 (actin filament associated protein 1 like 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01277,730,760 - 277,827,299 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01285,110,704 - 285,206,347 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41263,220,056 - 263,256,132 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11263,431,340 - 263,470,406 (-)NCBI
Celera1251,661,305 - 251,756,440 (-)NCBICelera
Cytogenetic Map1q55NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model

Annotation    (Toggle Annotation Detail/Summary View)

Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
  
More on Afap1l2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1310668
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



Contact Us |  About Us |  License CC BY 4.0 |  Legal Disclaimer |  © Medical College of Wisconsin
NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.