RGD Reference Report - Mapping of novel genes predisposing or protecting diabetes development in the BB/OK rat. - Rat Genome Database

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Mapping of novel genes predisposing or protecting diabetes development in the BB/OK rat.

Authors: Kloting, I  Chmidt S, S  Kovacs, P 
Citation: Kloting I, etal., Biochem Biophys Res Commun 1998 Apr 17;245(2):483-6
RGD ID: 61077
Pubmed: PMID:9571179   (View Abstract at PubMed)
DOI: DOI:10.1006/bbrc.1998.8464   (Journal Full-text)

By several crossing studies it has been demonstrated that the MHC class-II genes of the RT1u haplotype, Iddm1, and the lymphopenia, Iddm2, are essential, but not sufficient for diabetes development in the BB rat. Using diabetic BB/OK and diabetes-resistant DA rats it has been shown that a third non-MHC gene, Iddm3, on chromosome 18 cosegregates with diabetes in the BB/OK rat subline. Because mapping results need not be consistent among different crosses, we genetically analysed a new cross population using diabetic BB/OK and diabetes-resistant SHR/Mol rats analysing 73 microsatellite markers. The genetic analysis of Iddm1 and Iddm2 homozygous [(BB/OK x SHR)F1 x BB/OK] first backcross hybrids (BC1) confirmed the action of Iddm3 and one predisposing non-MHC locus, Iddm4, near Ighe/D6Mgh2 on chromosome 6 and one protective locus, Iddm5r(esistance), detected around Igf2/Tnt on chromosome 1. From these novel findings it is concluded that the diabetogenic phenotype of the BB/OK rat subline is the result of the interaction of predisposing and protecting diabetes genes.

RGD Manual Disease Annotations    Click to see Annotation Detail View

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Iddm4Rattype 1 diabetes mellitus  IAGP  RGD 

Objects Annotated

Iddm16  (Insulin dependent diabetes mellitus QTL 16)
Iddm4  (Insulin dependent diabetes mellitus QTL 4)
Iddm8  (Insulin dependent diabetes mellitus QTL 8)

BB/OK  (BioBreeding rat)
DA  (DA)
SHR/Mol  (NA)

Objects referenced in this article
Marker D6Mgh2 D6Mgh2 Rattus norvegicus
Strain BB.SHR-(D6Rat184-D6Rat101)/K null Rattus norvegicus
Strain BB.SHR-(D6Rat184-D6Rat3)/K null Rattus norvegicus
Strain BB/N BioBreeding rat Rattus norvegicus
QTL Iddm9 Insulin dependent diabetes mellitus QTL 9 Rattus norvegicus
Strain SHR Spontaneously Hypertensive Rat Rattus norvegicus

Additional Information