Dusp5 (dual specificity phosphatase 5)

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Gene: Dusp5 (dual specificity phosphatase 5) Rattus norvegicus

Analyze

Symbol:

Dusp5

Name:

dual specificity phosphatase 5

RGD ID:

620854

Description:

Enables MAP kinase tyrosine/serine/threonine phosphatase activity. Involved in negative regulation of DNA-templated transcription; negative regulation of vasoconstriction; and positive regulation of cerebral blood circulation. Predicted to be active in cytoplasm and nucleus. Orthologous to human DUSP5 (dual specificity phosphatase 5); PARTICIPATES IN mitogen activated protein kinase signaling pathway; INTERACTS WITH 1,2,4-trimethylbenzene; 1,3-dinitrobenzene; 17alpha-ethynylestradiol.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

candidate plasticity-related gene 21; Cpg21; dual specificity protein phosphatase 5; MAP-kinase phosphatase (cpg21); MAP-kinase phosphatase CPG21

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	DUSP5 (dual specificity phosphatase 5)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Dusp5 (dual specificity phosphatase 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Dusp5 (dual specificity phosphatase 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	DUSP5 (dual specificity phosphatase 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	DUSP5 (dual specificity phosphatase 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Dusp5 (dual specificity phosphatase 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	DUSP5 (dual specificity phosphatase 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	DUSP5 (dual specificity phosphatase 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Dusp5 (dual specificity phosphatase 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	DUSP5 (dual specificity phosphatase 5)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Dusp5 (dual specificity phosphatase 5)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	dusp5 (dual specificity phosphatase 5)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	MSG5	Alliance	DIOPT (Ensembl Compara\|PANTHER\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	dusp5	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Allele / Splice:

Dusp5^em1Mcwi

Genetic Models:

FHH-Chr 1^BN-Dusp5^em1Mcwi

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	1	252,538,408 - 252,555,320 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	252,538,449 - 252,551,818 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	260,727,398 - 260,740,843 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	267,433,474 - 267,446,919 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	260,088,694 - 260,102,130 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	274,245,184 - 274,258,595 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	274,245,184 - 274,258,595 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	281,658,075 - 281,671,486 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	259,754,234 - 259,767,645 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	259,965,278 - 259,978,690 (+)	NCBI
Celera	1	248,260,550 - 248,274,143 (+)	NCBI		Celera
Cytogenetic Map	1	q55	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

atherosclerosis (ISO)

Brain Injuries (IEP)

Cardiac Fibrosis (IEP)

Cornelia de Lange syndrome 3 (ISO)

Fetal Growth Retardation (IEP)

genetic disease (ISO)

hypertension (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-demecolcine (ISO)

(-)-epigallocatechin 3-gallate (ISO)

1,2,4-trimethylbenzene (EXP)

1,3-dinitrobenzene (EXP)

17alpha-ethynylestradiol (EXP,ISO)

17beta-estradiol (EXP,ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dinitrotoluene (EXP)

2-amino-2-deoxy-D-glucopyranose (EXP)

2-hydroxypropanoic acid (ISO)

3,3',5,5'-tetrabromobisphenol A (ISO)

3,4-methylenedioxymethamphetamine (ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-sulfonyldiphenol (ISO)

5-aza-2'-deoxycytidine (ISO)

5-fluorouracil (ISO)

6-propyl-2-thiouracil (EXP)

acetylsalicylic acid (EXP)

acrylamide (ISO)

afimoxifene (ISO)

aflatoxin B1 (ISO)

aldehydo-D-glucosamine (EXP)

all-trans-retinoic acid (EXP,ISO)

alpha-naphthoflavone (ISO)

ammonium chloride (EXP)

antirheumatic drug (ISO)

aristolochic acid A (ISO)

arsenite(3-) (ISO)

arsenous acid (ISO)

astragaloside IV (ISO)

azathioprine (ISO)

azoxystrobin (EXP)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

benzo[e]pyrene (ISO)

beta-D-glucosamine (EXP)

bexarotene (ISO)

bilirubin IXalpha (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bortezomib (ISO)

butan-1-ol (ISO)

cadmium atom (ISO)

cadmium dichloride (EXP,ISO)

calcitriol (ISO)

cannabidiol (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

chloroacetaldehyde (ISO)

chloropicrin (ISO)

chlorpyrifos (EXP,ISO)

chromium(6+) (ISO)

cidofovir anhydrous (ISO)

cisplatin (ISO)

cobalt dichloride (EXP,ISO)

cocaine (EXP)

copper atom (ISO)

copper(0) (ISO)

copper(II) sulfate (ISO)

crocidolite asbestos (ISO)

curcumin (ISO)

cyclosporin A (ISO)

cylindrospermopsin (ISO)

cyproconazole (EXP)

dexamethasone (ISO)

diallyl trisulfide (ISO)

diarsenic trioxide (ISO)

dibutyl phthalate (EXP,ISO)

dimethylarsinous acid (ISO)

dinophysistoxin 1 (ISO)

dioxygen (ISO)

disulfiram (ISO)

diuron (EXP)

dorsomorphin (ISO)

endosulfan (EXP)

entinostat (ISO)

febuxostat (ISO)

fenarimol (EXP)

fenofibrate (ISO)

flavonoids (EXP)

fluoranthene (ISO)

fluoxetine (EXP)

flusilazole (EXP)

genistein (ISO)

gentamycin (EXP)

glyphosate (EXP,ISO)

hydrogen peroxide (ISO)

hydroquinone (ISO)

ibuprofen (ISO)

imidacloprid (EXP)

indometacin (ISO)

isoprenaline (EXP)

leflunomide (ISO)

Licochalcone B (ISO)

lipopolysaccharide (ISO)

malathion (ISO)

manganese(II) chloride (EXP)

mercury dibromide (ISO)

mercury dichloride (EXP)

metformin (EXP,ISO)

methamphetamine (EXP)

methapyrilene (ISO)

methoxychlor (EXP)

methylisothiazolinone (ISO)

methylmercury chloride (ISO)

mono(2-ethylhexyl) phthalate (EXP,ISO)

N,N-diethyl-m-toluamide (EXP)

N-methyl-4-phenylpyridinium (ISO)

N-methyl-N-nitrosourea (EXP)

N-nitrosodiethylamine (ISO)

N-Nitrosopyrrolidine (ISO)

naphthalenes (EXP)

nickel atom (ISO)

nickel sulfate (ISO)

nicotinic acid (EXP)

oxaliplatin (EXP)

ozone (EXP)

p-chloromercuribenzoic acid (ISO)

panobinostat (ISO)

paracetamol (EXP,ISO)

paraquat (EXP)

perfluorononanoic acid (ISO)

perfluorooctanoic acid (EXP)

permethrin (EXP)

phenobarbital (ISO)

phenylmercury acetate (ISO)

pirinixic acid (ISO)

potassium chromate (ISO)

progesterone (ISO)

propiconazole (EXP)

quercetin (ISO)

rac-lactic acid (ISO)

raloxifene (ISO)

resorcinol (ISO)

rotenone (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

SB 203580 (ISO)

SB 431542 (ISO)

scopolamine (EXP)

silicon dioxide (ISO)

silver atom (ISO)

silver(0) (ISO)

sodium arsenite (ISO)

Soman (EXP)

sotorasib (ISO)

sulforaphane (ISO)

sunitinib (ISO)

tamoxifen (ISO)

Tanshinone I (ISO)

temozolomide (ISO)

tert-butyl hydroperoxide (ISO)

testosterone (ISO)

thapsigargin (ISO)

thiabendazole (EXP)

thioacetamide (EXP)

topotecan (EXP)

trametinib (ISO)

triadimefon (EXP)

Tributyltin oxide (EXP)

trichloroethene (EXP)

trichostatin A (ISO)

triclosan (ISO)

triphenyl phosphate (ISO)

triptonide (ISO)

tris(2-butoxyethyl) phosphate (ISO)

trovafloxacin (ISO)

tunicamycin (ISO)

urethane (ISO)

valdecoxib (EXP)

valproic acid (ISO)

valsartan (ISO)

vanadyl sulfate (ISO)

zinc atom (EXP,ISO)

zinc sulfate (EXP)

zinc(0) (EXP,ISO)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

dephosphorylation (IEA,ISO)

endoderm formation (IBA)

negative regulation of DNA-templated transcription (IDA)

negative regulation of MAPK cascade (IBA)

negative regulation of vasoconstriction (IMP)

positive regulation of cerebral blood circulation (IMP)

Cellular Component

cytoplasm (IBA)

nucleus (IBA,IEA)

Molecular Function

MAP kinase tyrosine phosphatase activity (IBA)

MAP kinase tyrosine/serine/threonine phosphatase activity (IBA,IDA,IEA)

myosin phosphatase activity (IEA)

phosphatase activity (ISO)

protein binding (ISO)

protein tyrosine phosphatase activity (IEA)

protein tyrosine/serine/threonine phosphatase activity (ISO)

protein tyrosine/threonine phosphatase activity (IBA)

Molecular Pathway Annotations Click to see Annotation Detail View

mitogen activated protein kinase signaling pathway (IEA)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

decreased vasoconstriction (IMP)

References

References - curated

#	Reference Title	Reference Citation
1.	Zinc-finger nuclease knockout of dual-specificity protein phosphatase-5 enhances the myogenic response and autoregulation of cerebral blood flow in FHH.1BN rats.	Fan F, etal., PLoS One. 2014 Nov 14;9(11):e112878. doi: 10.1371/journal.pone.0112878. eCollection 2014.
2.	Growth retardation alters the epigenetic characteristics of hepatic dual specificity phosphatase 5.	Fu Q, etal., FASEB J. 2006 Oct;20(12):2127-9. Epub 2006 Aug 29.
3.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4.	Hippocampal plasticity involves extensive gene induction and multiple cellular mechanisms.	Hevroni D, etal., J Mol Neurosci 1998 Apr;10(2):75-98.
5.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
6.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
7.	Traumatic brain injury-induced acute gene expression changes in rat cerebral cortex identified by GeneChip analysis.	Raghavendra Rao VL, etal., J Neurosci Res. 2003 Jan 15;71(2):208-19.
8.	GOA pipeline	RGD automated data pipeline
9.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
10.	Comprehensive gene review and curation	RGD comprehensive gene curation
11.	Association of astragaloside IV-inhibited autophagy and mineralization in vascular smooth muscle cells with lncRNA H19 and DUSP5-mediated ERK signaling.	Song Z, etal., Toxicol Appl Pharmacol. 2019 Feb 1;364:45-54. doi: 10.1016/j.taap.2018.12.002. Epub 2018 Dec 5.
12.	Long noncoding RNA H19 controls DUSP5/ERK1/2 axis in cardiac fibroblast proliferation and fibrosis.	Tao H, etal., Cardiovasc Pathol. 2016 Sep-Oct;25(5):381-9. doi: 10.1016/j.carpath.2016.05.005. Epub 2016 Jun 2.

Additional References at PubMed

PMID:7961985	PMID:21828247	PMID:23172031	PMID:23720316	PMID:24531476	PMID:26511729	PMID:29108992	PMID:31118214	PMID:31960618	PMID:32480039	PMID:33361528	PMID:33744332
PMID:34944046

Genomics

Comparative Map Data

Dusp5
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	1	252,538,408 - 252,555,320 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	252,538,449 - 252,551,818 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	260,727,398 - 260,740,843 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	267,433,474 - 267,446,919 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	260,088,694 - 260,102,130 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	274,245,184 - 274,258,595 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	274,245,184 - 274,258,595 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	281,658,075 - 281,671,486 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	259,754,234 - 259,767,645 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	259,965,278 - 259,978,690 (+)	NCBI
Celera	1	248,260,550 - 248,274,143 (+)	NCBI		Celera
Cytogenetic Map	1	q55	NCBI

DUSP5
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	10	110,497,907 - 110,511,533 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	10	110,497,907 - 110,511,533 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	10	112,257,665 - 112,271,291 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	10	112,247,615 - 112,261,292 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	10	112,247,665 - 112,261,285	NCBI
Celera	10	105,989,248 - 106,002,922 (+)	NCBI		Celera
Cytogenetic Map	10	q25.2	NCBI
HuRef	10	105,887,410 - 105,900,899 (+)	NCBI		HuRef
CHM1_1	10	112,539,502 - 112,553,176 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	10	111,381,715 - 111,395,339 (+)	NCBI		T2T-CHM13v2.0

Dusp5
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	19	53,517,576 - 53,530,240 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	19	53,517,540 - 53,530,862 (+)	Ensembl		GRCm39 Ensembl
GRCm38	19	53,529,145 - 53,541,809 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	19	53,529,109 - 53,542,431 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	19	53,603,808 - 53,615,812 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	19	53,582,342 - 53,595,731 (+)	NCBI		MGSCv36	mm8
Celera	19	55,721,417 - 55,733,621 (+)	NCBI		Celera
Cytogenetic Map	19	D2	NCBI
cM Map	19	47.98	NCBI

Dusp5
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955485	915,353 - 927,460 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955485	914,250 - 927,640 (-)	NCBI	ChiLan1.0	ChiLan1.0

DUSP5
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	10	122,383,709 - 122,398,623 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	10	107,091,147 - 107,105,971 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	10	110,545,021 - 110,556,445 (+)	NCBI	panpan1.1	PanPan1.1	panPan2

DUSP5
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	28	21,829,891 - 21,844,590 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	28	21,829,921 - 21,841,454 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	28	21,983,301 - 21,995,944 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	28	22,356,548 - 22,369,215 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	28	22,356,266 - 22,369,200 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	28	21,916,200 - 21,928,876 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	28	21,920,279 - 21,932,914 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	28	22,056,666 - 22,069,360 (+)	NCBI		UU_Cfam_GSD_1.0

Dusp5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	24,200,271 - 24,210,196 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936486	1,347,885 - 1,359,903 (+)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936486	1,351,077 - 1,361,002 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

DUSP5
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	120,906,343 - 120,919,384 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	14	120,906,340 - 120,919,398 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	131,791,167 - 131,803,458 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

DUSP5
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	9	103,435,015 - 103,449,100 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	9	103,435,343 - 103,449,171 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666048	64,637,733 - 64,651,729 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Dusp5
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624737	35,784,852 - 35,798,382 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624737	35,785,133 - 35,798,201 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Dusp5
83 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	140
Count of miRNA genes:	97
Interacting mature miRNAs:	120
Transcripts:	ENSRNOT00000018889
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1354610	Bw34	Body weight QTL 34	4.1		body mass (VT:0001259)	body weight (CMO:0000012)	1	151162512	256448636	Rat
1354646	Kidm18	Kidney mass QTL 18	5.7		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	1	151162512	256448636	Rat
1354661	Bw33	Body weight QTL 33	5.2		body mass (VT:0001259)	body weight (CMO:0000012)	1	151162512	256448636	Rat
1549837	Hcar15	Hepatocarcinoma resistance QTL 15		0.05	liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	1	153136852	260522016	Rat
1354580	Scort1	Serum corticosterone level QTL 1	3.4		blood corticosterone amount (VT:0005345)	blood corticosterone level (CMO:0001172)	1	156677124	256448636	Rat
738032	Hcas5	Hepatocarcinoma susceptibility QTL 5	3.12		liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	1	176426412	257976495	Rat
1354624	Cm35	Cardiac mass QTL35	5.7		heart left ventricle mass (VT:0007031)	calculated heart weight (CMO:0000073)	1	177227632	256448636	Rat
1354652	Kidm20	Kidney mass QTL 20	4.3		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	1	177227632	256448636	Rat
1578763	Kidm29	Kidney mass QTL 29	3.3	0.0001	kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	1	179567751	260522016	Rat
1600388	Niddm67	Non-insulin dependent diabetes mellitus QTL 67	5.84	0.000004	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	1	195804352	257091168	Rat
1600395	Niddm69	Non-insulin dependent diabetes mellitus QTL 69	4.14	0.0002	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	1	195804352	257091168	Rat
1600396	Niddm68	Non-insulin dependent diabetes mellitus QTL 68	4.97	0.0003	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	1	195804352	257091168	Rat
634313	Niddm43	Non-insulin dependent diabetes mellitus QTL 43			blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	199050459	259647894	Rat
1358890	Bp259	Blood pressure QTL 259	3.06		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	210702053	260522016	Rat
734768	Niddm59	Non-insulin dependent diabetes mellitus QTL 59			body mass (VT:0001259)	body weight (CMO:0000012)	1	213843987	258843987	Rat
70211	Niddm24	Non-insulin dependent diabetes mellitus QTL 24	3.79		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	1	214647894	259647894	Rat
1549910	Bw54	Body weight QTL 54		0.05	body mass (VT:0001259)	body weight (CMO:0000012)	1	214647894	259647894	Rat
61327	Eae7	Experimental allergic encephalomyelitis QTL 7	5.6		body mass (VT:0001259)	change in body weight (CMO:0002045)	1	216255568	260522016	Rat
2302040	Pia35	Pristane induced arthritis QTL 35	3.8	0.001	blood immunoglobulin amount (VT:0002460)	serum immunoglobulin G1 level (CMO:0002115)	1	216255568	260522016	Rat
1598821	Rf55	Renal function QTL 55	6.3		renal blood flow trait (VT:2000006)	ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)	1	218748008	257976495	Rat
724533	Rf51	Renal function QTL 51	5.3	0.0002	kidney plasma flow trait (VT:0005524)	renal plasma flow (CMO:0001914)	1	218753816	256448513	Rat
731175	Uae20	Urinary albumin excretion QTL 20	3.5	0.0018	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	1	221264111	259647894	Rat
10053715	Scort24	Serum corticosterone level QTL 24	2.13	0.0088	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	1	221414816	260522016	Rat
724552	Glom2	Glomerulus QTL 2	3.3	0.0001	kidney glomerulus morphology trait (VT:0005325)	count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)	1	222363780	260522016	Rat
1600392	Bw123	Body weight QTL 123		0.001	body mass (VT:0001259)	body weight (CMO:0000012)	1	223201027	260522016	Rat
734767	Niddm57	Non-insulin dependent diabetes mellitus QTL 57			body mass (VT:0001259)	body weight (CMO:0000012)	1	224054293	260122809	Rat
631843	Bw116	Body weight QTL 116	4.1	0.016	abdominal adipose amount (VT:1000220)	abdominal fat pad weight (CMO:0000088)	1	224054293	260122809	Rat
734769	Niddm58	Non-insulin dependent diabetes mellitus QTL 58			body mass (VT:0001259)	body weight (CMO:0000012)	1	224569538	260122809	Rat
631215	Stl8	Serum triglyceride level QTL 8	9.27	0.0001	blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	1	225126575	260522016	Rat
1300108	Rf8	Renal function QTL 8	3.75		renal blood flow trait (VT:2000006)	absolute change in renal vascular resistance (CMO:0001900)	1	228581588	259647894	Rat
1581544	Rf52	Renal function QTL 52		0.05	urine total protein amount (VT:0000032)	urine protein excretion rate to body weight ratio (CMO:0001099)	1	232156370	259647894	Rat
631669	Iddm9	Insulin dependent diabetes mellitus QTL 9	2.8	0.039	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	1	233190394	258625266	Rat
631536	Lnnr2	Liver neoplastic nodule remodeling QTL 2	2.9	0.0005	liver integrity trait (VT:0010547)	liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)	1	233948574	260522016	Rat
631690	Scl5	Serum cholesterol level QTL 5	2.1		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	1	236125214	260522016	Rat
631836	Stl31	Serum triglyceride level QTL 31	4.64	0.00000487	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	1	237147813	260522016	Rat
631837	Niddm35	Non-insulin dependent diabetes mellitus QTL 35		0.01	blood insulin amount (VT:0001560)	serum insulin level (CMO:0000358)	1	238699859	259647894	Rat
1598839	Rf56	Renal function QTL 56			renal blood flow trait (VT:2000006)	ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)	1	245907761	257976495	Rat

Markers in Region

BE111304

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	252,541,408 - 252,541,587 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	274,248,144 - 274,248,322	NCBI	Rnor6.0
Rnor_5.0	1	281,661,035 - 281,661,213	UniSTS	Rnor5.0
RGSC_v3.4	1	259,757,194 - 259,757,372	UniSTS	RGSC3.4
Celera	1	248,263,510 - 248,263,688	UniSTS
RH 3.4 Map	1	1673.1	UniSTS
Cytogenetic Map	1	q55	UniSTS

Genetic Models

This gene Dusp5 is modified in the following models/strains

FHH-Chr 1^BN-Dusp5^em1Mcwi

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	1	19			2				8	22	4	3
Low	2	24	57	41	17	41	6	9	66	13	37	8	6
Below cutoff							2	2					2

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_133578	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039087790	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC115255	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF013144	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473986	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000054	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000018889 ⟹ ENSRNOP00000018889

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	1	252,538,449 - 252,551,818 (+)	Ensembl
Rnor_6.0 Ensembl	1	274,245,184 - 274,258,595 (+)	Ensembl

RefSeq Acc Id:

NM_133578 ⟹ NP_598262

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	1	252,538,449 - 252,551,879 (+)	NCBI
Rnor_6.0	1	274,245,184 - 274,258,595 (+)	NCBI
Rnor_5.0	1	281,658,075 - 281,671,486 (+)	NCBI
RGSC_v3.4	1	259,754,234 - 259,767,645 (+)	RGD
Celera	1	248,260,550 - 248,274,143 (+)	RGD

Sequence:

show sequence

AGCTTTCCGGGGCAGCGAGTGGCGGGGCCGGGTGCTGAGCGAGCGGGGCGTGGAGAGCGTCGCG
CGGCCCCTCGCGCCGGGCTCCGTTTGCAGGCCACAGCCCCCGCGAGGTGGCCCGCCGGCCCTGG
GCCGCCCGTCCTCTGGCAGCTGTGGTGAGCGCAGCGTCGGGCCGGCATGAAGGTCACGTCGCTC
GACGGGCGCCGGCTGCGCAAGATGCTCCGCAAGGAGGCGGAGGCGCGCTGCGTGGTGCTCGATT
GCCGGCCCTACCTGGCCTTCGCCGCGTCGAGCGTGCGCGGCTCGCTCAACGTCAACCTCAACTC
CGTGGTGCTGCGGCGGGCCCGGGGCGGCGCGGTGTCTGCGCGCTACGTGCTGGCCGACGAGGCA
GCCCGCGCTCGGCTGCTGCAGGAGGGCGGCGGCGGCGTGGCGGCGGTGGTCGTGCTGGACCAGG
GCAGCCGCCACTGGCAGAAGCTGCGGGAGGAGAGTGCCGCGCGCGTCGTCCTCACCTCGCTGCT
GGCCTGTCTGTCCGCCGGACCGCGGGTCTACTTCCTTAAAGGTGGGTACGAGACCTTCTACTCA
CAGTATCCTGAGTGCTGTGTGGATGCGAAGCCCATTTCACAAGAGAAGCTCGAAGGTGAAAGAG
GCCTCCTCAGCCAGTGCGGAAAGCCCATTCTCAGCGTCGCCTACAGACCAGCTTATGACCAGGG
TGGCCCAGTTGAAATCCTTCCCTTCCTCTACCTTGGAAGTGCCTACCATGCATCCAAGTGCGAG
TTCCTCGCCAACCTGCACATCACAGCCCTGCTGAATGTTTCCCGCCGGACCTCTGAGGCCTGCA
CAACCCACCTACACTACAAGTGGATCCCTGTGGAGGACAGCCACACCGCCGACATTAGCTCCCA
CTTTCAAGAAGCAATAGATTTTATTGACTGTGTCAGGGAAGAGGGAGGCAAGGTCCTGGTTCAC
TGTGAAGCCGGGGTCTCCCGGTCGCCCACCATCTGCATGGCTTACCTCATGAAGACCAAGCAGT
TCCGCCTGAAGGAGGCCTTCGAGTATATCAAGCAGAGGAGGAGCGTGGTCTCTCCCAACTTTGG
CTTCATGGGACAGCTCCTGCAGTATGAGTCTGAGATCCTGCCCTCCACACCCACCCCCCAACCT
CCCTCCTGCCAAGGGGAGGCAGCCAGCTCCACCTTTATAGGCCACTTACAGACACTGAGCCCTG
ATATGCAGGGTGCCTACTGCACATTCCCTACCTCAGTGCTGGCACCGGTGCCCACCCACGCCAC
CGTCGCAGAGCTCCACAGGAGCCCCGTGGCCACAGCCACATCCTGCTGAGACCGGTCGGCTACC
AGCGCATCCCCAAGAGCAACTGTGACCTTTGGATTTTTTAAACTTGTGGACATTTCATACCCGT
GCAATACTGAAGACCTCTCTCTGTCCCGCTGCCCCGGTGAGATGGTGAGGGGTCAGCAGGCTTG
CAGATGCACTTCAGGCTAACCCGGAGGATGGTTTCTCGCGATTGTAGGAAGGCCAAGCCATGCC
CCCCTAGCACAGCGGCGTGCTAACTACTGTACTTCCAGAAGCCCCGCCCACTCAGGACCGCCTC
ATCCTTGCACCTCAGAAGTCCCGGCTTCTCATTTCAAGTGTAAGGCAATACACAGTCGCAGCAA
AGTAGGAGCAAGCTGTGCTGGACCAGGAGGGGAGGAGTCCGCCCGTCTGGGAGGAAGCACAAGT
TTCACTGTTAATTTGAATTTCGGCCAACTTTGTCTGTCTCTGTCCTCTGTCACTTCAGGGAAGA
GAGCTGGTCACCGCTCAGTCAGAAAAGTTAACCCCGCTGGATTTGTCAAGACAAAAGGACCTGC
CCGTCTGAACCCAGTGTTTCTGAGGTTCTGTCTAGGATCCCATGGAAGCTGTTGGTGTAAGGAG
AAGCTCCTGACTCATTGGAGTTTCTTGCTCACCGAGGGCTCCTTGGTGACCTTGGACTTTGGCA
TGGTTTTTACAAATACTTGAACCTGTCCCATTGTATCTCTCCCTAAAGCACCTCTGGTGTCATT
CAGAAAGTTGTCAGACCCTAGACCAAAAACCACCCCTTTGAGGGGGTAGCAGGAACTGCCTGCG
TTCTGGGTCAGTGGTGGTGACTGACATACTTTTTCAGTTTAGTGTCCTGTGTGCTTTTTTTGTC
ATCCATTGTGACAATGTTTCCCTCCCTACCCTGGGGAGTCGTTTTCAAACTACTGATTCTGGGG
TCTGCATCGTTTGCAATGTGGTACTACTATGTCCTTCGTAGATTGTTTTTCCAAGGGGGGAAAG
GCAATAAGTCACCCCCAAACCCATGTGAATGTGAAGAAAAGCAGTGTTGATGTTTTTTTTATAT
ATATATATATACATGTAGTACAAAATTAAAAAAATGTCAAAAAATAAAAATAAAAAGTGCTAAG
TGAA

hide sequence

RefSeq Acc Id:

XM_039087790 ⟹ XP_038943718

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	1	252,538,408 - 252,555,320 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_598262	(Get FASTA)	NCBI Sequence Viewer
	XP_038943718	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAB94858	(Get FASTA)	NCBI Sequence Viewer
	EDL94434	(Get FASTA)	NCBI Sequence Viewer
	EDL94435	(Get FASTA)	NCBI Sequence Viewer
	O54838	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_598262 ⟸ NM_133578

- UniProtKB:

O54838 (UniProtKB/Swiss-Prot), F1LPJ5 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MKVTSLDGRRLRKMLRKEAEARCVVLDCRPYLAFAASSVRGSLNVNLNSVVLRRARGGAVSARY
VLADEAARARLLQEGGGGVAAVVVLDQGSRHWQKLREESAARVVLTSLLACLSAGPRVYFLKGG
YETFYSQYPECCVDAKPISQEKLEGERGLLSQCGKPILSVAYRPAYDQGGPVEILPFLYLGSAY
HASKCEFLANLHITALLNVSRRTSEACTTHLHYKWIPVEDSHTADISSHFQEAIDFIDCVREEG
GKVLVHCEAGVSRSPTICMAYLMKTKQFRLKEAFEYIKQRRSVVSPNFGFMGQLLQYESEILPS
TPTPQPPSCQGEAASSTFIGHLQTLSPDMQGAYCTFPTSVLAPVPTHATVAELHRSPVATATSC

hide sequence

RefSeq Acc Id:

ENSRNOP00000018889 ⟸ ENSRNOT00000018889

RefSeq Acc Id:	XP_038943718 ⟸ XM_039087790
- Peptide Label:	isoform X1

Protein Domains

Rhodanese Tyrosine specific protein phosphatases Tyrosine-protein phosphatase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-O54838-F1-model_v2	AlphaFold	O54838	1-384	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:620854	AgrOrtholog
BioCyc Gene	G2FUF-55384	BioCyc
Ensembl Genes	ENSRNOG00000014061	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000018889	ENTREZGENE
	ENSRNOP00000018889.2	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000018889	ENTREZGENE
	ENSRNOT00000018889.5	UniProtKB/TrEMBL
Gene3D-CATH	3.40.250.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	3.90.190.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	Dual-sp_phosphatase_cat-dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	MKP	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Prot-tyrosine_phosphatase-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Rhodanese-like_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Rhodanese-like_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Tyr_Pase_AS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Tyr_Pase_cat	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TYR_PHOSPHATASE_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TYR_PHOSPHATASE_DUAL_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:171109	UniProtKB/Swiss-Prot
NCBI Gene	171109	ENTREZGENE
PANTHER	DUAL SPECIFICITY PROTEIN PHOSPHATASE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	DUAL SPECIFICITY PROTEIN PHOSPHATASE 5	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	DSPc	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Rhodanese	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Dusp5	PhenoGen
PIRSF	MAPK_Ptase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS	MAPKPHPHTASE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	RHODANESE_3	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TYR_PHOSPHATASE_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TYR_PHOSPHATASE_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TYR_PHOSPHATASE_DUAL	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART	DSPc	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTPc_motif	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	RHOD	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF52799	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF52821	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A6JHW0_RAT	UniProtKB/TrEMBL
	A6JHW1_RAT	UniProtKB/TrEMBL
	DUS5_RAT	UniProtKB/Swiss-Prot
	F1LPJ5	ENTREZGENE, UniProtKB/TrEMBL
	O54838	ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2004-09-10	Dusp5	dual specificity phosphatase 5	Cpg21	MAP-kinase phosphatase (cpg21)	Symbol and Name updated	1299863	APPROVED
2002-08-07	Cpg21	MAP-kinase phosphatase (cpg21)			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_regulation	induced in brain after glutamate receptor activation	68228

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Annotations - KEGG (archival)

Mammalian Phenotype

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Annotations - KEGG (archival)

Mammalian Phenotype