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Gene: Plce1 (phospholipase C, epsilon 1) Rattus norvegicus
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Symbol: Plce1
Name: phospholipase C, epsilon 1
Description: Exhibits Ras GTPase binding activity and phosphatidylinositol phospholipase C activity. Involved in G protein-coupled receptor signaling pathway and Ras protein signal transduction. Localizes to the cytoplasm. Human ortholog(s) of this gene implicated in nephrotic syndrome; nephrotic syndrome type 2; and nephrotic syndrome type 3. Orthologous to human PLCE1 (phospholipase C epsilon 1); PARTICIPATES IN calcium/calcium-mediated signaling pathway; inositol phosphate metabolic pathway; phosphatidylinositol 3-kinase signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase epsilon-1; phosphoinositide phospholipase C-epsilon-1; phosphoinositide-specific phospholipase C epsilon-1; phospholipase C epsilon; phospholipase C epsilon 1; phospholipase C, epsilon; phospholipase C-epsilon-1; PLC-epsilon-1; Plce
Orthologs:
Homo sapiens (human) : PLCE1 (phospholipase C epsilon 1)  HGNC  Alliance
Mus musculus (house mouse) : Plce1 (phospholipase C, epsilon 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Plce1 (phospholipase C epsilon 1)
Pan paniscus (bonobo/pygmy chimpanzee) : PLCE1 (phospholipase C epsilon 1)
Canis lupus familiaris (dog) : PLCE1 (phospholipase C epsilon 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Plce1 (phospholipase C epsilon 1)
Sus scrofa (pig) : PLCE1 (phospholipase C epsilon 1)
more info ...
Allele / Splice: Plce1Tn(sb-T2/Bart3)2.146Mcwi  
Genetic Models: F344-Plce1Tn(sb-T2/Bart3)2.146Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01257,156,023 - 257,465,440 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01264,652,842 - 264,956,664 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41242,794,858 - 243,103,437 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11242,891,416 - 243,199,995 (+)NCBI
Celera1233,337,820 - 233,642,815 (+)NCBICelera
Cytogenetic Map1q53NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
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Genomics

Comparative Map Data
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QTLs in Region (Rnor_6.0)
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Sequence

Nucleotide Sequences
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Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Plce1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 69424
Created: 2001-11-27
Species: Rattus norvegicus
Last Modified: 2019-06-18
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.