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Gene: PLCE1 (phospholipase C epsilon 1) Homo sapiens
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Symbol: PLCE1
Name: phospholipase C epsilon 1
Description: Exhibits Ras GTPase binding activity and phosphatidylinositol phospholipase C activity. Involved in several processes, including Ras protein signal transduction; phospholipase C-activating G protein-coupled receptor signaling pathway; and regulation of signal transduction. Localizes to the cytosol and plasma membrane. Implicated in nephrotic syndrome; nephrotic syndrome type 2; and nephrotic syndrome type 3.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase epsilon-1; FLJ23659; KIAA1516; MGC167842; NPHS3; pancreas-enriched phospholipase C; phosphoinositide phospholipase C; phosphoinositide phospholipase C-epsilon-1; phosphoinositide-specific phospholipase C epsilon-1; phospholipase C, epsilon 1; phospholipase C-epsilon-1; PLC-epsilon-1; PLCE; PPLC
Orthologs:
Mus musculus (house mouse) : Plce1 (phospholipase C, epsilon 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Plce1 (phospholipase C, epsilon 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Plce1 (phospholipase C epsilon 1)
Pan paniscus (bonobo/pygmy chimpanzee) : PLCE1 (phospholipase C epsilon 1)
Canis lupus familiaris (dog) : PLCE1 (phospholipase C epsilon 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Plce1 (phospholipase C epsilon 1)
Sus scrofa (pig) : PLCE1 (phospholipase C epsilon 1)
Chlorocebus sabaeus (African green monkey) : PLCE1 (phospholipase C epsilon 1)
Heterocephalus glaber (naked mole-rat) : Plce1 (phospholipase C epsilon 1)
more info ...
Related Pseudogenes: PLCE1P1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl1094,030,812 - 94,332,823 (+)EnsemblGRCh38hg38GRCh38
GRCh381093,993,931 - 94,332,823 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371095,753,746 - 96,088,149 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361095,743,736 - 96,078,139 (+)NCBINCBI36hg18NCBI36
Celera1089,493,881 - 89,828,255 (+)NCBI
Cytogenetic Map10q23.33NCBI
HuRef1089,417,740 - 89,714,892 (+)NCBIHuRef
CHM1_11096,072,191 - 96,370,190 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
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Nomenclature History
 
More on PLCE1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1606000
Created: 2007-04-28
Species: Homo sapiens
Last Modified: 2020-03-24
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.