Casp7 (caspase 7) - Rat Genome Database

Send us a Message

Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Casp7 (caspase 7) Rattus norvegicus
Symbol: Casp7
Name: caspase 7
RGD ID: 620944
Description: Enables cysteine-type peptidase activity. Involved in leukocyte apoptotic process; protein catabolic process; and striated muscle cell differentiation. Predicted to be active in cytosol; extracellular space; and nucleus. Biomarker of several diseases, including endometritis; sciatic neuropathy; transient cerebral ischemia; type 2 diabetes mellitus; and ureteral obstruction. Human ortholog(s) of this gene implicated in Alzheimer's disease; breast cancer; colon cancer; and lung non-small cell carcinoma. Orthologous to human CASP7 (caspase 7); PARTICIPATES IN extrinsic apoptotic pathway; FasL mediated signaling pathway; glutathione metabolic pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: caspase-7
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Casp7Tn(sb-T2/Bart3)2.280Mcwi  
Genetic Models: F344-Casp7Tn(sb-T2/Bart3)2.280Mcwi
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr81265,442,647 - 265,481,938 (+)NCBIGRCr8
mRatBN7.21255,437,438 - 255,476,737 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1255,437,172 - 255,476,729 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1263,654,318 - 263,686,579 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01270,360,357 - 270,392,618 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01263,006,435 - 263,038,671 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01277,190,557 - 277,242,779 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1277,190,964 - 277,242,774 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01284,572,208 - 284,623,736 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41262,689,300 - 262,721,591 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11262,900,344 - 262,932,633 (+)NCBI
Celera1251,144,026 - 251,176,065 (+)NCBICelera
Cytogenetic Map1q55NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(-)-cotinine  (ISO)
(-)-gambogic acid  (ISO)
(1->4)-beta-D-glucan  (ISO)
(aminomethyl)phosphonic acid  (ISO)
(R)-noradrenaline  (ISO)
(R,R,R)-alpha-tocopherol  (ISO)
(S)-naringenin  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,2-dimethylhydrazine  (ISO)
1,4-benzoquinone  (ISO)
1-[4-(1,3-benzodioxol-5-ylmethyl)-1-piperazinyl]-2-(4-chlorophenoxy)ethanone  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
1H-pyrazole  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',4,5-tetrachlorobiphenyl  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (EXP)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
2-acetamidofluorene  (EXP)
2-amino-2-deoxy-D-galactopyranose  (ISO)
2-methoxy-17beta-estradiol  (ISO)
2-tert-butylhydroquinone  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-chloropropane-1,2-diol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methyl-3H-imidazo[4,5-f]quinolin-2-amine  (ISO)
3-methyladenine  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-aminopyridine  (EXP)
4-hydroxy-TEMPO  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nonylphenol  (EXP)
4-phenylbutyric acid  (EXP,ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-(cyclohexylmethoxy)-5-nitrosopyrimidine-2,4-diamine  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (ISO)
6-propyl-2-thiouracil  (EXP)
7-ketocholesterol  (ISO)
9-cis-retinoic acid  (EXP)
ABT-737  (ISO)
acetamide  (EXP)
acetylleucyl-leucyl-norleucinal  (ISO)
acetylsalicylic acid  (ISO)
acrolein  (ISO)
acrylamide  (ISO)
actinomycin D  (ISO)
AICA ribonucleotide  (ISO)
all-trans-retinoic acid  (ISO)
alpha-mangostin  (ISO)
alpha-pinene  (ISO)
alpidem  (ISO)
aminoguanidine  (ISO)
amiodarone  (ISO)
amlodipine  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
antirheumatic drug  (ISO)
Antrocin  (ISO)
apigenin  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
bafilomycin A1  (ISO)
beauvericin  (EXP)
belinostat  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (EXP,ISO)
benzophenanthridine  (ISO)
beta-carboline  (ISO)
betulinic acid  (ISO)
bicalutamide  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
brassinin  (ISO)
brilliant green  (ISO)
buspirone  (EXP)
butylated hydroxyanisole  (ISO)
C.I. Natural Red 20  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cadmium sulfate  (ISO)
cadmium sulfide  (ISO)
Calcimycin  (ISO)
calcitriol  (ISO)
camptothecin  (ISO)
cannabidiol  (ISO)
capsaicin  (ISO)
carbon monoxide  (EXP)
carbon nanotube  (ISO)
carboplatin  (ISO)
casticin  (ISO)
catechol  (ISO)
celecoxib  (ISO)
ceric oxide  (ISO)
chalcones  (ISO)
chelerythrine  (ISO)
chloroacetic acid  (ISO)
chloroquine  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
chondroitin sulfate  (ISO)
chromium(6+)  (ISO)
cilostazol  (EXP)
cimetidine  (ISO)
cisplatin  (EXP,ISO)
cladribine  (ISO)
clofarabine  (ISO)
clomipramine  (ISO)
clozapine  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (EXP,ISO)
copper(II) sulfate  (ISO)
cordycepin  (EXP)
coumarin  (ISO)
coumestrol  (EXP)
crizotinib  (ISO)
crocidolite asbestos  (ISO)
crotonaldehyde  (EXP)
Cryptotanshinone  (ISO)
crystal violet  (ISO)
cucurbitacin E  (ISO)
cucurbitacin I  (ISO)
curcumin  (ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
cypermethrin  (EXP,ISO)
cyproconazole  (EXP)
dapagliflozin  (EXP)
decabromodiphenyl ether  (ISO)
deguelin  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (EXP,ISO)
dexmedetomidine  (ISO)
Di-n-octyl phthalate  (ISO)
diarsenic trioxide  (EXP,ISO)
diazinon  (EXP)
dibenz[a,h]anthracene  (EXP)
dibutyl phthalate  (ISO)
dieldrin  (EXP)
dihydrocapsaicin  (ISO)
Dimethyl phthalate  (EXP)
dioscin  (ISO)
diosmin  (EXP)
dipyridamole  (ISO)
disodium selenite  (ISO)
disulfiram  (ISO)
dopamine  (ISO)
dorsomorphin  (EXP)
doxorubicin  (EXP,ISO)
dronedarone  (ISO)
edaravone  (ISO)
ellipticine  (ISO)
endosulfan  (ISO)
epoxiconazole  (EXP)
equol  (ISO)
eriocitrin  (ISO)
esculetin  (ISO)
estrone  (ISO)
etodolac  (ISO)
etoposide  (ISO)
eugenol  (ISO)
fipronil  (ISO)
fisetin  (ISO)
flavanones  (ISO)
flavonols  (ISO)
flecainide  (ISO)
flunitrazepam  (ISO)
fluoxetine  (ISO)
flutamide  (EXP)
fluvoxamine  (ISO)
folic acid  (ISO)
folpet  (ISO)
formononetin  (ISO)
fructose  (EXP)
fucoxanthin  (ISO)
fumonisin B1  (ISO)
gallic acid  (ISO)
gamma-hexachlorocyclohexane  (EXP)
geldanamycin  (ISO)
genistein  (ISO)
glutathione  (ISO)
glyphosate  (EXP,ISO)
gold atom  (ISO)
gold(0)  (ISO)
gossypin  (ISO)
gossypol  (ISO)
guanidines  (ISO)
harman  (ISO)
herbicide  (ISO)
hexadecanoic acid  (EXP,ISO)
homocysteine  (ISO)
hyaluronic acid  (ISO)
hydrogen peroxide  (EXP,ISO)
hydroquinone  (ISO)
hydroxyurea  (ISO)
imipramine  (ISO)
indole-3-methanol  (ISO)
indometacin  (ISO)
iron(2+) sulfate (anhydrous)  (ISO)
isoalantolactone  (ISO)
Isoangustone A  (ISO)
isoflurane  (EXP)
isoprenaline  (EXP,ISO)
ivermectin  (ISO)
ketoconazole  (EXP)
L-ascorbic acid  (ISO)
L-methionine  (ISO)
lapatinib  (ISO)
lead nitrate  (ISO)
lipopolysaccharide  (ISO)
lithium atom  (ISO)
lithium carbonate  (ISO)
lithium chloride  (ISO)
lithium hydride  (ISO)
loratadine  (ISO)
Lupiwighteone  (ISO)
luteolin  (ISO)
LY294002  (EXP,ISO)
mancozeb  (ISO)
maneb  (ISO)
manganese atom  (EXP)
manganese(0)  (EXP)
mebendazole  (ISO)
memantine  (ISO)
menaquinone  (ISO)
mercury dichloride  (ISO)
metformin  (EXP,ISO)
methcathinone  (ISO)
methidathion  (ISO)
methimazole  (EXP)
methotrexate  (ISO)
methoxyacetic acid  (ISO)
methoxychlor  (ISO)
methylcobalamin  (ISO)
methylglyoxal  (ISO)
methylmercury chloride  (ISO)
methylseleninic acid  (ISO)
mevalonic acid  (ISO)
microcystin-LR  (ISO)
minocycline  (EXP)
mitomycin C  (ISO)
Mitotane  (EXP,ISO)
mitoxantrone  (ISO)
MK-2206  (ISO)
molybdenum atom  (ISO)
monensin A  (ISO)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
morin  (ISO)
Muconic dialdehyde  (ISO)
Myrtucommulone A  (ISO)
N-(3-oxododecanoyl)homoserine lactone  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (EXP)
N-tosyl-L-phenylalanyl chloromethyl ketone  (ISO)
nefazodone  (ISO)
nelfinavir  (ISO)
nickel atom  (ISO)
nickel dichloride  (EXP,ISO)
niclosamide  (ISO)
nilotinib  (ISO)
nimetazepam  (ISO)
nimodipine  (ISO)
nitrazepam  (ISO)
nitric oxide  (ISO)
nitroprusside  (EXP,ISO)
nortriptyline  (ISO)
NS-398  (ISO)
Nutlin-3  (ISO)
ochratoxin A  (EXP,ISO)
octadecanoic acid  (EXP)
okadaic acid  (ISO)
omacetaxine mepesuccinate  (ISO)
omipalisib  (ISO)
oxidopamine  (EXP,ISO)
ozone  (ISO)
p-menthan-3-ol  (ISO)
paclitaxel  (ISO)
palbociclib  (ISO)
paracetamol  (ISO)
paraquat  (EXP,ISO)
pentobarbital  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
phenanthridone  (ISO)
phentolamine  (ISO)
pifithrin-?  (EXP,ISO)
pirinixic acid  (EXP)
platycodin D  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
propafenone  (ISO)
propranolol  (ISO)
propylparaben  (ISO)
pterostilbene  (ISO)
pyrene  (EXP)
pyrimethamine  (ISO)
pyrrolidine dithiocarbamate  (EXP)
quercetin  (ISO)
raloxifene  (ISO)
razoxane  (ISO)
reactive oxygen species  (ISO)
remdesivir  (ISO)
resveratrol  (EXP,ISO)
ribavirin  (ISO)
Riluzole  (ISO)
risperidone  (ISO)
rotenone  (ISO)
rubimaillin  (ISO)
rutin  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
Salinomycin  (ISO)
sappanchalcone  (ISO)
SB 203580  (ISO)
selumetinib  (ISO)
serotonin  (ISO)
sertraline  (ISO)
Sesamol  (ISO)
sevoflurane  (ISO)
Shikonin  (ISO)
simvastatin  (ISO)
sirolimus  (EXP,ISO)
SKF 38393  (ISO)
sodium acetate trihydrate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
solasodine  (ISO)
Soman  (EXP)
sorafenib  (ISO)
spermine  (ISO)
spironolactone  (ISO)
staurosporine  (EXP,ISO)
streptozocin  (EXP)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
sulindac sulfide  (ISO)
sunitinib  (ISO)
T-2 toxin  (ISO)
tamoxifen  (ISO)
tauroursodeoxycholic acid  (ISO)
temozolomide  (ISO)
terbutaline  (ISO)
tert-butyl hydroperoxide  (EXP,ISO)
tetrachloromethane  (ISO)
thapsigargin  (ISO)
thymoquinone  (ISO)
ticlopidine  (ISO)
titanium dioxide  (ISO)
Tomentosin  (ISO)
topotecan  (ISO)
trametinib  (ISO)
tributylstannane  (EXP)
Tributyltin oxide  (ISO)
trichostatin A  (EXP,ISO)
Triptolide  (EXP,ISO)
troglitazone  (ISO)
trovafloxacin  (EXP)
tunicamycin  (ISO)
ursodeoxycholic acid  (ISO)
ursolic acid  (ISO)
usnic acid  (ISO)
valproic acid  (ISO)
venom  (ISO)
verapamil  (ISO)
vinclozolin  (EXP)
vinorelbine  (ISO)
vorinostat  (ISO)
WIN 55212-2  (ISO)
wortmannin  (ISO)
xanthohumol  (ISO)
zileuton  (ISO)
zinc pyrithione  (ISO)
zoledronic acid  (ISO)


References - curated
# Reference Title Reference Citation
1. Chemopreventive effect of a novel oleanane triterpenoid in a chemically induced rodent model of breast cancer. Bishayee A, etal., Int J Cancer. 2013 Sep 1;133(5):1054-63. doi: 10.1002/ijc.28108. Epub 2013 Mar 29.
2. Pomegranate exerts chemoprevention of experimentally induced mammary tumorigenesis by suppression of cell proliferation and induction of apoptosis. Bishayee A, etal., Nutr Cancer. 2016;68(1):120-30. doi: 10.1080/01635581.2016.1115094. Epub 2015 Dec 23.
3. Caspase-7 ablation modulates UPR, reprograms TRAF2-JNK apoptosis and protects T17M rhodopsin mice from severe retinal degeneration. Choudhury S, etal., Cell Death Dis. 2013 Mar 7;4:e528. doi: 10.1038/cddis.2013.34.
4. Age-related alterations in expression of apoptosis regulatory proteins and heat shock proteins in rat skeletal muscle. Chung L and Ng YC, Biochim Biophys Acta. 2006 Jan;1762(1):103-9. Epub 2005 Aug 24.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Implication of caspases and subcellular compartments in tert-butylhydroperoxide induced apoptosis. Haidara K, etal., Toxicol Appl Pharmacol. 2008 May 15;229(1):65-76. Epub 2008 Jan 29.
8. Effect of carvedilol against myocardial injury due to ischemia-reperfusion of the brain in rats. Harima M, etal., Exp Mol Pathol. 2015 Jun;98(3):558-62. doi: 10.1016/j.yexmp.2015.04.001. Epub 2015 Apr 11.
9. Expression and differential processing of caspases 6 and 7 in relation to specific epileptiform EEG patterns following limbic seizures. Henshall DC, etal., Neurobiol Dis 2002 Jul;10(2):71-87.
10. Caspase function in programmed cell death. Kumar S Cell Death Differ. 2007 Jan;14(1):32-43. Epub 2006 Nov 3.
11. The hyperglycemia stimulated myocardial endoplasmic reticulum (ER) stress contributes to diabetic cardiomyopathy in the transgenic non-obese type 2 diabetic rats: a differential role of unfolded protein response (UPR) signaling proteins. Lakshmanan AP, etal., Int J Biochem Cell Biol. 2013 Feb;45(2):438-47. doi: 10.1016/j.biocel.2012.09.017. Epub 2012 Sep 29.
12. Caspase-7 deficiency protects from endotoxin-induced lymphocyte apoptosis and improves survival. Lamkanfi M, etal., Blood. 2009 Mar 19;113(12):2742-5. Epub 2009 Jan 23.
13. Polymorphisms in the caspase genes and the risk of lung cancer. Lee SY, etal., J Thorac Oncol. 2010 Aug;5(8):1152-8. doi: 10.1097/JTO.0b013e3181e04543.
14. Targeting the XIAP/caspase-7 complex selectively kills caspase-3-deficient malignancies. Lin YF, etal., J Clin Invest. 2013 Sep;123(9):3861-75. doi: 10.1172/JCI67951. Epub 2013 Aug 27.
15. Selenium Plays a Protective Role in Staphylococcus aureus-Induced Endometritis in the Uterine Tissue of Rats. Liu Y, etal., Biol Trace Elem Res. 2016 Oct;173(2):345-53. doi: 10.1007/s12011-016-0659-6. Epub 2016 Feb 26.
16. Hypochlorite modified albumins promote cell death in the tubule interstitium in rats via mitochondrial damage in obstructive nephropathy and the protective effects of antioxidant peptides. Liu ZR, etal., Free Radic Res. 2018 May;52(5):616-628. doi: 10.1080/10715762.2018.1457789.
17. Depletion of the mRNA translation initiation inhibitor, programmed cell death protein 4 (PDCD4), impairs L6 myotube formation. Maeda N, etal., Physiol Rep. 2017 Sep;5(17). pii: 5/17/e13395. doi: 10.14814/phy2.13395.
18. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
19. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
20. Compound 21 and Telmisartan combination mitigates type 2 diabetic nephropathy through amelioration of caspase mediated apoptosis. Pandey A and Gaikwad AB, Biochem Biophys Res Commun. 2017 Jun 10;487(4):827-833. doi: 10.1016/j.bbrc.2017.04.134. Epub 2017 Apr 27.
21. Playing the DISC: turning on TRAIL death receptor-mediated apoptosis in cancer. Pennarun B, etal., Biochim Biophys Acta. 2010 Apr;1805(2):123-40. Epub 2009 Dec 2.
22. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
23. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
24. Caspase gene expression in the brain as a function of the clinical progression of Alzheimer disease. Pompl PN, etal., Arch Neurol. 2003 Mar;60(3):369-76.
25. Retinal gene expression after central retinal artery ligation: effects of ischemia and reperfusion. Prasad SS, etal., Invest Ophthalmol Vis Sci. 2010 Dec;51(12):6207-19. Epub 2010 Aug 11.
26. GOA pipeline RGD automated data pipeline
27. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
28. Genome-wide haplotype association study identify TNFRSF1A, CASP7, LRP1B, CDH1 and TG genes associated with Alzheimer's disease in Caribbean Hispanic individuals. Shang Z, etal., Oncotarget. 2015 Dec 15;6(40):42504-14. doi: 10.18632/oncotarget.6391.
29. Anti-inflammatory and anti-apoptotic effects of rosuvastatin by regulation of oxidative stress in a dextran sulfate sodium-induced colitis model. Shin SK, etal., World J Gastroenterol. 2017 Jul 7;23(25):4559-4568. doi: 10.3748/wjg.v23.i25.4559.
30. The many roles of FAS receptor signaling in the immune system. Strasser A, etal., Immunity. 2009 Feb 20;30(2):180-92.
31. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
32. Genetic and expression analysis of CASP7 gene in a European Caucasian population with rheumatoid arthritis. Teixeira VH, etal., J Rheumatol. 2008 Oct;35(10):1912-8. Epub 2008 Sep 1.
33. Transient Receptor Potential Channel, Vanilloid 5, Induces Chondrocyte Apoptosis in a Rat Osteoarthritis Model Through the Mediation of Ca2+ Influx. Wei Y, etal., Cell Physiol Biochem. 2018;46(2):687-698. doi: 10.1159/000488725. Epub 2018 Mar 29.
34. Evaluation of apoptotic pathways in dorsal root ganglion neurons following peripheral nerve injury. Wiberg R, etal., Neuroreport. 2018 Jun 13;29(9):779-785. doi: 10.1097/WNR.0000000000001031.
35. Luteinizing hormone-induced caspase activation in rat preovulatory follicles is coupled to mitochondrial steroidogenesis. Yacobi K, etal., Endocrinology. 2007 Apr;148(4):1717-26. Epub 2007 Jan 11.
36. Caspase-7, Fas and FasL in long-term renal ischaemia/reperfusion and immunosuppressive injuries in rats. Yang B, etal., Am J Nephrol. 2007;27(4):397-408. Epub 2007 Jun 26.
37. Protection effect of survivin protein overexpression on acute myocardial infarction in rats. Yang M, etal., Int J Clin Exp Med. 2015 Aug 15;8(8):12995-3000. eCollection 2015.
38. Time course of apoptosis induced by photodynamic therapy with PsD007 in LT12 acute myeloid leukemia cells. Yin H, etal., Lasers Med Sci. 2016 Jul;31(5):817-24. doi: 10.1007/s10103-016-1887-x. Epub 2016 Feb 9.
39. Proteolytic cleavage of ataxin-7 by caspase-7 modulates cellular toxicity and transcriptional dysregulation. Young JE, etal., J Biol Chem. 2007 Oct 12;282(41):30150-60. Epub 2007 Jul 23.
40. Cardioprotection of tilianin ameliorates myocardial ischemia-reperfusion injury: Role of the apoptotic signaling pathway. Zeng C, etal., PLoS One. 2018 Mar 14;13(3):e0193845. doi: 10.1371/journal.pone.0193845. eCollection 2018.
Additional References at PubMed
PMID:12888622   PMID:15231831   PMID:15953353   PMID:16123172   PMID:16183742   PMID:16469926   PMID:17167422   PMID:17464193   PMID:19740745   PMID:19759058   PMID:22253444   PMID:22526145  
PMID:23963709   PMID:24185830   PMID:24704558  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr81265,442,647 - 265,481,938 (+)NCBIGRCr8
mRatBN7.21255,437,438 - 255,476,737 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1255,437,172 - 255,476,729 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1263,654,318 - 263,686,579 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01270,360,357 - 270,392,618 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01263,006,435 - 263,038,671 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01277,190,557 - 277,242,779 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1277,190,964 - 277,242,774 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01284,572,208 - 284,623,736 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41262,689,300 - 262,721,591 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11262,900,344 - 262,932,633 (+)NCBI
Celera1251,144,026 - 251,176,065 (+)NCBICelera
Cytogenetic Map1q55NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh3810113,679,194 - 113,730,909 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl10113,679,162 - 113,730,907 (+)EnsemblGRCh38hg38GRCh38
GRCh3710115,438,953 - 115,490,668 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3610115,428,925 - 115,480,654 (+)NCBINCBI36Build 36hg18NCBI36
Build 3410115,428,952 - 115,480,652NCBI
Celera10109,166,297 - 109,218,022 (+)NCBICelera
Cytogenetic Map10q25.3NCBI
HuRef10109,065,803 - 109,118,487 (+)NCBIHuRef
CHM1_110115,720,952 - 115,772,694 (+)NCBICHM1_1
T2T-CHM13v2.010114,571,036 - 114,622,770 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391956,382,640 - 56,430,780 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1956,385,561 - 56,430,776 (+)EnsemblGRCm39 Ensembl
GRCm381956,396,833 - 56,442,348 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1956,397,129 - 56,442,344 (+)EnsemblGRCm38mm10GRCm38
MGSCv371956,471,619 - 56,516,834 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361956,450,379 - 56,495,594 (+)NCBIMGSCv36mm8
Celera1958,584,433 - 58,629,610 (+)NCBICelera
Cytogenetic Map19D2NCBI
cM Map1951.84NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495543118,686,190 - 18,723,524 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543118,685,408 - 18,723,221 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1-v28125,557,882 - 125,609,366 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110125,563,218 - 125,614,702 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v010110,273,318 - 110,324,800 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.110113,707,188 - 113,758,630 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl10113,707,780 - 113,758,626 (+)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.12824,599,866 - 24,630,018 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2824,599,493 - 24,628,668 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2824,751,150 - 24,781,371 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02825,131,618 - 25,161,826 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2825,131,720 - 25,161,823 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12824,688,961 - 24,719,167 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02824,696,885 - 24,727,323 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02824,896,252 - 24,926,727 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440721321,446,342 - 21,478,385 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364864,088,372 - 4,114,955 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364864,082,664 - 4,114,942 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl14124,019,164 - 124,050,365 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114124,017,776 - 124,050,369 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.19106,558,291 - 106,607,662 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl9106,559,445 - 106,607,663 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604867,773,257 - 67,822,203 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_00462473732,852,835 - 32,887,069 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473732,853,354 - 32,888,881 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Casp7
228 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:146
Count of miRNA genes:117
Interacting mature miRNAs:126
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1156677124256448636Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1176426412257976495Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1177227632256448636Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1177227632256448636Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1179567751260522016Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1195804352257091168Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1199050459259647894Rat
1358890Bp259Blood pressure QTL 2593.06arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1210702053260522016Rat
734768Niddm59Non-insulin dependent diabetes mellitus QTL 59body mass (VT:0001259)body weight (CMO:0000012)1213843987258843987Rat
70211Niddm24Non-insulin dependent diabetes mellitus QTL 243.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1214647894259647894Rat
1549910Bw54Body weight QTL 540.05body mass (VT:0001259)body weight (CMO:0000012)1214647894259647894Rat
61327Eae7Experimental allergic encephalomyelitis QTL 75.6body mass (VT:0001259)change in body weight (CMO:0002045)1216255568260522016Rat
2302040Pia35Pristane induced arthritis QTL 353.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1216255568260522016Rat
1598821Rf55Renal function QTL 556.3renal blood flow trait (VT:2000006)ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)1218748008257976495Rat
724533Rf51Renal function QTL 515.30.0002kidney plasma flow trait (VT:0005524)renal plasma flow (CMO:0001914)1218753816256448513Rat
731175Uae20Urinary albumin excretion QTL 203.50.0018urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1221264111259647894Rat
10053715Scort24Serum corticosterone level QTL 242.130.0088blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1221414816260522016Rat
724552Glom2Glomerulus QTL 23.30.0001kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)1222363780260522016Rat
1600392Bw123Body weight QTL 1230.001body mass (VT:0001259)body weight (CMO:0000012)1223201027260522016Rat
734767Niddm57Non-insulin dependent diabetes mellitus QTL 57body mass (VT:0001259)body weight (CMO:0000012)1224054293260122809Rat
631843Bw116Body weight QTL 1164.10.016abdominal adipose amount (VT:1000220)abdominal fat pad weight (CMO:0000088)1224054293260122809Rat
734769Niddm58Non-insulin dependent diabetes mellitus QTL 58body mass (VT:0001259)body weight (CMO:0000012)1224569538260122809Rat
631215Stl8Serum triglyceride level QTL 89.270.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1225126575260522016Rat
1300108Rf8Renal function QTL 83.75renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)1228581588259647894Rat
1581544Rf52Renal function QTL 520.05urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)1232156370259647894Rat
631669Iddm9Insulin dependent diabetes mellitus QTL 92.80.039blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1233190394258625266Rat
631536Lnnr2Liver neoplastic nodule remodeling QTL 22.90.0005liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)1233948574260522016Rat
631690Scl5Serum cholesterol level QTL 52.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1236125214260522016Rat
631836Stl31Serum triglyceride level QTL 314.640.00000487blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1237147813260522016Rat
631837Niddm35Non-insulin dependent diabetes mellitus QTL 350.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1238699859259647894Rat
1598839Rf56Renal function QTL 56renal blood flow trait (VT:2000006)ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)1245907761257976495Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21255,451,831 - 255,452,046 (+)MAPPERmRatBN7.2
Rnor_6.01277,217,914 - 277,218,128NCBIRnor6.0
Rnor_5.01284,598,995 - 284,599,209UniSTSRnor5.0
RGSC_v3.41262,696,668 - 262,696,882UniSTSRGSC3.4
Celera1251,151,373 - 251,151,587UniSTS
RH 3.4 Map11683.2UniSTS
Cytogenetic Map1q55UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21255,476,168 - 255,476,262 (+)MAPPERmRatBN7.2
Rnor_6.01277,242,214 - 277,242,307NCBIRnor6.0
Rnor_5.01284,623,171 - 284,623,264UniSTSRnor5.0
RGSC_v3.41262,721,026 - 262,721,119UniSTSRGSC3.4
Celera1251,175,500 - 251,175,593UniSTS
Cytogenetic Map1q55UniSTS

Genetic Models
This gene Casp7 is modified in the following models/strains:


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 3 25 43 39 12 39 2 15 32 30 11
Low 18 14 2 7 2 8 9 59 3 11 8
Below cutoff


RefSeq Acc Id: ENSRNOT00000080511   ⟹   ENSRNOP00000075193
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1255,437,172 - 255,476,721 (+)Ensembl
Rnor_6.0 Ensembl1277,190,964 - 277,242,774 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000103804   ⟹   ENSRNOP00000081060
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1255,458,618 - 255,476,729 (+)Ensembl
RefSeq Acc Id: NM_022260   ⟹   NP_071596
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
GRCr81265,442,647 - 265,481,938 (+)NCBI
mRatBN7.21255,437,438 - 255,476,734 (+)NCBI
Rnor_6.01277,210,548 - 277,242,779 (+)NCBI
Rnor_5.01284,572,208 - 284,623,736 (+)NCBI
RGSC_v3.41262,689,300 - 262,721,591 (+)RGD
Celera1251,144,026 - 251,176,065 (+)RGD
RefSeq Acc Id: XM_008760547   ⟹   XP_008758769
Rat AssemblyChrPosition (strand)Source
GRCr81265,462,939 - 265,481,938 (+)NCBI
mRatBN7.21255,458,470 - 255,476,737 (+)NCBI
Rnor_6.01277,223,727 - 277,242,779 (+)NCBI
RefSeq Acc Id: NP_071596   ⟸   NM_022260
- UniProtKB: O88550 (UniProtKB/TrEMBL),   A6JI19 (UniProtKB/TrEMBL),   A0A0G2K9Z4 (UniProtKB/TrEMBL),   Q6IRF9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008758769   ⟸   XM_008760547
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZQU7 (UniProtKB/TrEMBL),   A6JI22 (UniProtKB/TrEMBL),   A0A0G2K9Z4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000075193   ⟸   ENSRNOT00000080511
RefSeq Acc Id: ENSRNOP00000081060   ⟸   ENSRNOT00000103804
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O88550-F1-model_v2 AlphaFold O88550 1-303 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13691002
Promoter ID:EPDNEW_R1527
Type:initiation region
Description:caspase 7
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.01277,191,089 - 277,191,149EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620944 AgrOrtholog
BioCyc Gene G2FUF-55325 BioCyc
Ensembl Genes ENSRNOG00000056216 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000080511 ENTREZGENE
  ENSRNOT00000080511.2 UniProtKB/TrEMBL
  ENSRNOT00000103804.1 UniProtKB/TrEMBL
  Caspase-like UniProtKB/TrEMBL
InterPro Caspase-like_dom UniProtKB/TrEMBL
  Caspase_cys_AS UniProtKB/TrEMBL
  Pept_C14_caspase UniProtKB/TrEMBL
  Pept_C14_ICE_p20 UniProtKB/TrEMBL
  Pept_C14_ICE_p20_AS UniProtKB/TrEMBL
  Pept_C14_p10 UniProtKB/TrEMBL
  Pept_C14_p45_core UniProtKB/TrEMBL
KEGG Report rno:64026 UniProtKB/TrEMBL
  PTHR10454:SF31 UniProtKB/TrEMBL
Pfam Peptidase_C14 UniProtKB/TrEMBL
PhenoGen Casp7 PhenoGen
RatGTEx ENSRNOG00000056216 RatGTEx
Superfamily-SCOP SSF52129 UniProtKB/TrEMBL
UniProt Secondary O88550 UniProtKB/TrEMBL

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-01-20 Casp7  caspase 7    caspase-7  Name updated 1299863 APPROVED
2002-08-07 Casp7  caspase-7      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_product member of the caspase family of cell death proteases 632425