Nt5c2 (5'-nucleotidase, cytosolic II) - Rat Genome Database

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Gene: Nt5c2 (5'-nucleotidase, cytosolic II) Rattus norvegicus
Analyze
Symbol: Nt5c2
Name: 5'-nucleotidase, cytosolic II
RGD ID: 2323387
Description: Enables GMP 5'-nucleotidase activity and IMP 5'-nucleotidase activity. Involved in adenosine metabolic process and purine nucleoside monophosphate metabolic process. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 45. Orthologous to human NT5C2 (5'-nucleotidase, cytosolic II); PARTICIPATES IN adenine phoshoribosyltransferase deficiency pathway; adenosine monophosphate deaminase deficiency pathway; adenylosuccinate lyase deficiency pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; cadmium dichloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: cytosolic nucleoside phosphotransferase 5'N; cytosolic purine 5'-nucleotidase; LOC100363253; LOC294016
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81255,712,797 - 255,838,285 (-)NCBIGRCr8
mRatBN7.21245,770,993 - 245,896,925 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1245,772,277 - 245,897,913 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1253,898,700 - 253,972,046 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01260,591,926 - 260,665,203 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01253,241,355 - 253,314,864 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01266,652,966 - 266,782,935 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1266,659,519 - 266,782,910 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01274,086,763 - 274,213,322 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41252,204,106 - 252,329,479 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11252,468,096 - 252,541,637 (-)NCBI
Celera1241,538,262 - 241,668,557 (-)NCBICelera
Cytogenetic Map1q54NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (ISO)
cytosol  (IEA,ISO,ISS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Purification and some properties of cytosol 5'-nucleotidase from rat liver. Itoh R, Biochim Biophys Acta. 1981 Feb 13;657(2):402-10. doi: 10.1016/0005-2744(81)90326-0.
3. Enzymes of adenosine metabolism in the brain: diurnal rhythm and the effect of sleep deprivation. Mackiewicz M, etal., J Neurochem. 2003 Apr;85(2):348-57.
4. Differences in cytosolic and mitochondrial 5'-nucleotidase and deoxynucleoside kinase activities in Sprague-Dawley rat and CD-1 mouse tissues: implication for the toxicity of nucleoside analogs in animal models. Mirzaee S, etal., Toxicology. 2010 Jan 12;267(1-3):159-64. Epub 2009 Nov 12.
5. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
6. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:2848805   PMID:17405878  


Genomics

Comparative Map Data
Nt5c2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81255,712,797 - 255,838,285 (-)NCBIGRCr8
mRatBN7.21245,770,993 - 245,896,925 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1245,772,277 - 245,897,913 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1253,898,700 - 253,972,046 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01260,591,926 - 260,665,203 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01253,241,355 - 253,314,864 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01266,652,966 - 266,782,935 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1266,659,519 - 266,782,910 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01274,086,763 - 274,213,322 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41252,204,106 - 252,329,479 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11252,468,096 - 252,541,637 (-)NCBI
Celera1241,538,262 - 241,668,557 (-)NCBICelera
Cytogenetic Map1q54NCBI
NT5C2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810103,088,017 - 103,193,272 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl10103,087,185 - 103,277,605 (-)EnsemblGRCh38hg38GRCh38
GRCh3710104,847,774 - 104,953,029 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3610104,837,902 - 104,943,006 (-)NCBINCBI36Build 36hg18NCBI36
Build 3410104,837,903 - 104,943,006NCBI
Celera1098,586,161 - 98,693,349 (-)NCBICelera
Cytogenetic Map10q24.32-q24.33NCBI
HuRef1098,482,286 - 98,586,909 (-)NCBIHuRef
CHM1_110105,130,653 - 105,236,813 (-)NCBICHM1_1
T2T-CHM13v2.010103,974,258 - 104,079,521 (-)NCBIT2T-CHM13v2.0
Nt5c2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391946,873,829 - 47,003,613 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1946,871,756 - 47,003,592 (-)EnsemblGRCm39 Ensembl
GRCm381946,885,390 - 47,015,174 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1946,883,317 - 47,015,153 (-)EnsemblGRCm38mm10GRCm38
MGSCv371946,961,321 - 47,089,679 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361946,941,140 - 47,015,619 (-)NCBIMGSCv36mm8
Celera1947,656,323 - 47,783,383 (-)NCBICelera
Cytogenetic Map19C3NCBI
cM Map1938.97NCBI
Nt5c2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554857,317,588 - 7,394,448 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554857,318,006 - 7,394,448 (+)NCBIChiLan1.0ChiLan1.0
NT5C2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28114,973,901 - 115,164,301 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110114,979,344 - 115,169,729 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01099,687,366 - 99,790,744 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.110103,148,578 - 103,251,513 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl10103,148,578 - 103,251,513 (-)Ensemblpanpan1.1panPan2
NT5C2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12815,525,581 - 15,621,287 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2815,526,790 - 15,621,235 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2815,697,211 - 15,791,400 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02816,000,755 - 16,095,008 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2816,000,764 - 16,147,185 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12815,550,611 - 15,644,750 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02815,581,995 - 15,676,317 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02815,716,631 - 15,810,917 (-)NCBIUU_Cfam_GSD_1.0
Nt5c2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721331,225,057 - 31,289,576 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049366002,828,277 - 2,892,795 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NT5C2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14114,062,459 - 114,145,109 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114114,062,451 - 114,167,460 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214124,033,935 - 124,116,597 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NT5C2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1996,133,873 - 96,325,122 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl996,135,400 - 96,219,956 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604857,243,704 - 57,438,013 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nt5c2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248312,371,804 - 2,529,726 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248312,374,341 - 2,468,819 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Nt5c2
511 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:127
Count of miRNA genes:105
Interacting mature miRNAs:113
Transcripts:ENSRNOT00000027351
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
631690Scl5Serum cholesterol level QTL 52.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1236125214260522016Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1177227632256448636Rat
2293674Bss39Bone structure and strength QTL 397.10.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)1201554356246554356Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
61327Eae7Experimental allergic encephalomyelitis QTL 75.6body mass (VT:0001259)change in body weight (CMO:0002045)1216255568260522016Rat
1600392Bw123Body weight QTL 1230.001body mass (VT:0001259)body weight (CMO:0000012)1223201027260522016Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1179567751260522016Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1195804352257091168Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1177227632256448636Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
631837Niddm35Non-insulin dependent diabetes mellitus QTL 350.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1238699859259647894Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1206081677251081677Rat
631836Stl31Serum triglyceride level QTL 314.645e-06blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1237147813260522016Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
2293694Bss38Bone structure and strength QTL 387.050.0001femur strength trait (VT:0010010)femur stiffness (CMO:0001674)1201554356246554356Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1150700247252085048Rat
1300108Rf8Renal function QTL 83.75renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)1228581588259647894Rat
734767Niddm57Non-insulin dependent diabetes mellitus QTL 57body mass (VT:0001259)body weight (CMO:0000012)1224054293260122809Rat
1358898Bp255Blood pressure QTL 2553.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1191019702246062233Rat
631215Stl8Serum triglyceride level QTL 89.270.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1225126575260522016Rat
631843Bw116Body weight QTL 1164.10.016abdominal adipose amount (VT:1000220)abdominal fat pad weight (CMO:0000088)1224054293260122809Rat
2300175Bmd40Bone mineral density QTL 4015.40.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)1201554356246554356Rat
731175Uae20Urinary albumin excretion QTL 203.50.0018urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1221264111259647894Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
724538Kidm1Kidney mass QTL 13.2kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1213707201252085212Rat
2293655Bss36Bone structure and strength QTL 3610.660.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1201554356246554356Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1150700142252085212Rat
734769Niddm58Non-insulin dependent diabetes mellitus QTL 58body mass (VT:0001259)body weight (CMO:0000012)1224569538260122809Rat
734768Niddm59Non-insulin dependent diabetes mellitus QTL 59body mass (VT:0001259)body weight (CMO:0000012)1213843987258843987Rat
1358890Bp259Blood pressure QTL 2593.06arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1210702053260522016Rat
724533Rf51Renal function QTL 515.30.0002kidney plasma flow trait (VT:0005524)renal plasma flow (CMO:0001914)1218753816256448513Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1156677124256448636Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1199050459259647894Rat
1549910Bw54Body weight QTL 540.05body mass (VT:0001259)body weight (CMO:0000012)1214647894259647894Rat
70211Niddm24Non-insulin dependent diabetes mellitus QTL 243.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1214647894259647894Rat
1357399Bw45Body weight QTL 453.05body mass (VT:0001259)body mass index (BMI) (CMO:0000105)1206329708251329708Rat
724552Glom2Glomerulus QTL 23.30.0001kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)1222363780260522016Rat
2316896Gluco57Glucose level QTL 577.2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1228985440245907899Rat
1357404Bw42Body weight QTL 424.490.0001body mass (VT:0001259)body weight (CMO:0000012)1206329708251329708Rat
10053715Scort24Serum corticosterone level QTL 242.130.0088blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1221414816260522016Rat
61400Niddm1Non-insulin dependent diabetes mellitus QTL 111blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1218753689245907899Rat
10059587Bw173Body weight QTL 1733.230.025body mass (VT:0001259)body weight (CMO:0000012)1202069611247069611Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
7387289Uae45Urinary albumin excretion QTL 452.860.0021urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1223262787260522016Rat
1581544Rf52Renal function QTL 520.05urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)1232156370259647894Rat
631536Lnnr2Liver neoplastic nodule remodeling QTL 22.90.0005liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)1233948574260522016Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1176426412257976495Rat
2302040Pia35Pristane induced arthritis QTL 353.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1216255568260522016Rat
631669Iddm9Insulin dependent diabetes mellitus QTL 92.80.039blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1233190394258625266Rat
7394701Uae46Urinary albumin excretion QTL 463.60.0056urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1201554356246554356Rat
1598821Rf55Renal function QTL 556.3renal blood flow trait (VT:2000006)ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)1218748008257976495Rat

Markers in Region
D1Got441  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21245,826,871 - 245,827,129 (+)MAPPERmRatBN7.2
Rnor_6.01266,712,977 - 266,713,232NCBIRnor6.0
Rnor_5.01274,142,908 - 274,143,163UniSTSRnor5.0
RGSC_v3.41252,259,546 - 252,259,801UniSTSRGSC3.4
Celera1241,598,135 - 241,598,390UniSTS
Cytogenetic Map1 RGD
AU046797  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21245,817,403 - 245,817,646 (+)MAPPERmRatBN7.2
Rnor_6.01266,703,514 - 266,703,756NCBIRnor6.0
Rnor_5.01274,133,445 - 274,133,687UniSTSRnor5.0
RGSC_v3.41252,250,083 - 252,250,325UniSTSRGSC3.4
Celera1241,588,793 - 241,589,035UniSTS
RH138834  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21245,771,683 - 245,771,836 (+)MAPPERmRatBN7.2
Rnor_6.01266,657,796 - 266,657,948NCBIRnor6.0
Rnor_5.01274,087,723 - 274,087,875UniSTSRnor5.0
RGSC_v3.41252,204,365 - 252,204,517UniSTSRGSC3.4
Celera1241,543,092 - 241,543,244UniSTS
RH 3.4 Map11627.7UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001401711 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_002728891 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_003753419 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006223765 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006223766 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006223768 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006231583 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008760495 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008774855 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017589894 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017590386 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101429 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101430 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101431 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101432 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063282768 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_215270 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC097752 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC105488 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473986 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000027351   ⟹   ENSRNOP00000027351
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1245,772,277 - 245,853,693 (-)Ensembl
Rnor_6.0 Ensembl1266,659,519 - 266,782,910 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000103151   ⟹   ENSRNOP00000081125
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1245,772,277 - 245,819,921 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000103587   ⟹   ENSRNOP00000096997
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1245,772,277 - 245,897,913 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000109343   ⟹   ENSRNOP00000096604
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1245,772,277 - 245,845,892 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000109706   ⟹   ENSRNOP00000080847
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1245,772,540 - 245,845,934 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000114230   ⟹   ENSRNOP00000084753
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1245,772,277 - 245,812,337 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000116166   ⟹   ENSRNOP00000088067
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1245,772,277 - 245,897,913 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000117913   ⟹   ENSRNOP00000097160
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1245,772,277 - 245,828,185 (-)Ensembl
RefSeq Acc Id: NM_001401711   ⟹   NP_001388640
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81255,713,909 - 255,787,267 (-)NCBI
mRatBN7.21245,772,536 - 245,845,904 (-)NCBI
RefSeq Acc Id: XM_002728891   ⟹   XP_002728937
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81255,712,797 - 255,838,285 (-)NCBI
mRatBN7.21245,770,993 - 245,896,925 (-)NCBI
Rnor_6.01266,659,516 - 266,782,935 (-)NCBI
Rnor_5.01274,086,763 - 274,213,322 (-)NCBI
RGSC_v3.41252,204,106 - 252,329,479 (-)RGD
Sequence:
RefSeq Acc Id: XM_039101429   ⟹   XP_038957357
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81255,712,797 - 255,777,139 (-)NCBI
mRatBN7.21245,770,993 - 245,835,763 (-)NCBI
RefSeq Acc Id: XM_039101430   ⟹   XP_038957358
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81255,712,797 - 255,787,386 (-)NCBI
mRatBN7.21245,770,993 - 245,846,149 (-)NCBI
RefSeq Acc Id: XM_039101431   ⟹   XP_038957359
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81255,712,797 - 255,774,938 (-)NCBI
mRatBN7.21245,770,993 - 245,833,578 (-)NCBI
RefSeq Acc Id: XM_039101432   ⟹   XP_038957360
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81255,712,797 - 255,724,736 (-)NCBI
mRatBN7.21245,770,993 - 245,783,380 (-)NCBI
RefSeq Acc Id: XM_063282768   ⟹   XP_063138838
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81255,712,797 - 255,788,798 (-)NCBI
RefSeq Acc Id: XP_002728937   ⟸   XM_002728891
- Peptide Label: isoform X2
- UniProtKB: A0A8I6GLV2 (UniProtKB/TrEMBL),   A0A8I6A978 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000027351   ⟸   ENSRNOT00000027351
RefSeq Acc Id: XP_038957358   ⟸   XM_039101430
- Peptide Label: isoform X1
- UniProtKB: D3ZMY7 (UniProtKB/Swiss-Prot),   A6JHP1 (UniProtKB/TrEMBL),   A0A8L2QH70 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038957357   ⟸   XM_039101429
- Peptide Label: isoform X1
- UniProtKB: D3ZMY7 (UniProtKB/Swiss-Prot),   A6JHP1 (UniProtKB/TrEMBL),   A0A8L2QH70 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038957359   ⟸   XM_039101431
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038957360   ⟸   XM_039101432
- Peptide Label: isoform X3
Ensembl Acc Id: ENSRNOP00000096997   ⟸   ENSRNOT00000103587
Ensembl Acc Id: ENSRNOP00000088067   ⟸   ENSRNOT00000116166
Ensembl Acc Id: ENSRNOP00000081125   ⟸   ENSRNOT00000103151
Ensembl Acc Id: ENSRNOP00000084753   ⟸   ENSRNOT00000114230
Ensembl Acc Id: ENSRNOP00000080847   ⟸   ENSRNOT00000109706
Ensembl Acc Id: ENSRNOP00000096604   ⟸   ENSRNOT00000109343
Ensembl Acc Id: ENSRNOP00000097160   ⟸   ENSRNOT00000117913
RefSeq Acc Id: NP_001388640   ⟸   NM_001401711
- UniProtKB: D3ZMY7 (UniProtKB/Swiss-Prot),   A6JHP1 (UniProtKB/TrEMBL),   A0A8L2QH70 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063138838   ⟸   XM_063282768
- Peptide Label: isoform X1
- UniProtKB: D3ZMY7 (UniProtKB/Swiss-Prot),   A6JHP1 (UniProtKB/TrEMBL),   A0A8L2QH70 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZMY7-F1-model_v2 AlphaFold D3ZMY7 1-560 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2323387 AgrOrtholog
BioCyc Gene G2FUF-55496 BioCyc
Ensembl Genes ENSRNOG00000020179 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00055003734 UniProtKB/Swiss-Prot
  ENSRNOG00060029685 UniProtKB/Swiss-Prot
  ENSRNOG00065030938 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000027351.8 UniProtKB/TrEMBL
  ENSRNOT00000103151.1 UniProtKB/TrEMBL
  ENSRNOT00000103587.1 UniProtKB/TrEMBL
  ENSRNOT00000109343.1 UniProtKB/TrEMBL
  ENSRNOT00000109706.1 UniProtKB/TrEMBL
  ENSRNOT00000114230.1 UniProtKB/TrEMBL
  ENSRNOT00000116166.1 UniProtKB/TrEMBL
  ENSRNOT00000117913.1 UniProtKB/TrEMBL
  ENSRNOT00055005980 UniProtKB/Swiss-Prot
  ENSRNOT00060052178 UniProtKB/Swiss-Prot
  ENSRNOT00065053608 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.1000 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro HAD-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HAD-SF_hydro_IG_5-nucl UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HAD_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pur_nucleotidase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 100363253 ENTREZGENE
PANTHER CYTOSOLIC PURINE 5'-NUCLEOTIDASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR12103 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 5_nucleotid UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Nt5c2 PhenoGen
PIRSF Purine_5'-nucleotidase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000020179 RatGTEx
  ENSRNOG00055003734 RatGTEx
  ENSRNOG00060029685 RatGTEx
  ENSRNOG00065030938 RatGTEx
Superfamily-SCOP SSF56784 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt 5NTC_RAT UniProtKB/Swiss-Prot
  A0A8I5ZQH0_RAT UniProtKB/TrEMBL
  A0A8I5ZQZ0_RAT UniProtKB/TrEMBL
  A0A8I6A1X9_RAT UniProtKB/TrEMBL
  A0A8I6A978 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6B4G3_RAT UniProtKB/TrEMBL
  A0A8I6GLV2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GME6_RAT UniProtKB/TrEMBL
  A0A8L2QH70 ENTREZGENE, UniProtKB/TrEMBL
  A6JHP1 ENTREZGENE, UniProtKB/TrEMBL
  D3ZMY7 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-09-11 Nt5c2  5'-nucleotidase, cytosolic II  LOC100363253  5'-nucleotidase, cytosolic II  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-05-06 LOC100363253  5'-nucleotidase, cytosolic II      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-04-30 Nt5c2  5'-nucleotidase, cytosolic II   Nt5c2_predicted  5'-nucleotidase, cytosolic II (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Nt5c2_predicted  5'-nucleotidase, cytosolic II (predicted)      Symbol and Name status set to approved 70820 APPROVED