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Gene: Nt5c2 (5'-nucleotidase, cytosolic II) Rattus norvegicus
Symbol: Nt5c2
Name: 5'-nucleotidase, cytosolic II
Description: Exhibits 5'-nucleotidase activity. Involved in IMP metabolic process and adenosine metabolic process. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 45. Orthologous to human NT5C2 (5'-nucleotidase, cytosolic II); PARTICIPATES IN adenine phoshoribosyltransferase deficiency pathway; adenosine monophosphate deaminase deficiency pathway; adenylosuccinate lyase deficiency pathway; INTERACTS WITH 1-naphthyl isothiocyanate; endosulfan; ketamine.
Type: protein-coding
RefSeq Status: MODEL
Also known as: cytosolic purine 5'-nucleotidase; LOC100363253; LOC294016
Homo sapiens (human) : NT5C2 (5'-nucleotidase, cytosolic II)  HGNC  Alliance
Mus musculus (house mouse) : Nt5c2 (5'-nucleotidase, cytosolic II)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nt5c2 (5'-nucleotidase, cytosolic II)
Pan paniscus (bonobo/pygmy chimpanzee) : NT5C2 (5'-nucleotidase, cytosolic II)
Canis lupus familiaris (dog) : NT5C2 (5'-nucleotidase, cytosolic II)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nt5c2 (5'-nucleotidase, cytosolic II)
Sus scrofa (pig) : NT5C2 (5'-nucleotidase, cytosolic II)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01266,652,966 - 266,782,935 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1266,659,519 - 266,782,910 (-)Ensembl
Rnor_5.01274,086,763 - 274,213,322 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41252,204,106 - 252,329,479 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11252,468,096 - 252,541,637 (-)NCBI
Celera1241,538,262 - 241,668,557 (-)NCBICelera
Cytogenetic Map1q54NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
More on Nt5c2
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2323387
Created: 2010-05-06
Species: Rattus norvegicus
Last Modified: 2019-11-27
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.